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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="ABF89000.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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    </evidence>
    <sequence length="122" mass="13166" checksum="E04AAE13C1DE4933" modified="2006-07-11" version="1">MERRHPMRALGLAVVLSMAGVPVAAEAASLRCGQALVADGALKTEVLAKCGEPAAKNFRTVTDSAGSVTPDRNTGGVTTERRSVTREYEEWTYNFGPRRFMQVVTFENGRLIDVQSAGYGSE</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
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            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF88420"/>
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    <dbReference type="KEGG" id="mxa:MXAN_7303"/>
    <dbReference type="HOGENOM" id="CLU_2700900_0_0_7"/>
    <dbReference type="OMA" id="MDEVWME"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="83" mass="9177" checksum="56C31F8654466538" modified="2006-07-11" version="1">MLVPGGEVPIMSAYDRYRALLNKLRLVRARHPEGDSPEEDGLLDDMDEVWMEMSEGERSAIATERARVLGLPKAQPADSAAQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW46</accession>
    <name>CAS3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Putative CRISPR-associated nuclease/helicase Cas3</fullName>
            <ecNumber>3.1.-.-</ecNumber>
            <ecNumber>3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cas3</name>
        <name type="ordered locus">MXAN_7264</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="J. Bacteriol." volume="189" first="3738" last="3750">
            <title>Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.</title>
            <authorList>
                <person name="Viswanathan P."/>
                <person name="Murphy K."/>
                <person name="Julien B."/>
                <person name="Garza A.G."/>
                <person name="Kroos L."/>
            </authorList>
            <dbReference type="PubMed" id="17369305"/>
            <dbReference type="DOI" id="10.1128/JB.00187-07"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>OPERON STRUCTURE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Operon expression begins by 6 hours after starvation has initiated development and is under strong negative regulation by DevS.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EC" id="3.6.4.-"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557183.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CW46"/>
    <dbReference type="SMR" id="Q1CW46"/>
    <dbReference type="STRING" id="246197.MXAN_7264"/>
    <dbReference type="EnsemblBacteria" id="ABF91789">
        <property type="protein sequence ID" value="ABF91789"/>
        <property type="gene ID" value="MXAN_7264"/>
    </dbReference>
    <dbReference type="GeneID" id="41364430"/>
    <dbReference type="KEGG" id="mxa:MXAN_7264"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013108_0_0_7"/>
    <dbReference type="OMA" id="FCYPTTG"/>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000418221" description="Putative CRISPR-associated nuclease/helicase Cas3">
        <location>
            <begin position="1"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="HD Cas3-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q53VY2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17369305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="746" mass="82292" checksum="7B1A00D279E4EFFA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW73</accession>
    <name>Q1CW73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87106">
        <property type="protein sequence ID" value="ABF87106"/>
        <property type="gene ID" value="MXAN_7237"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7237"/>
    <dbReference type="HOGENOM" id="CLU_3273147_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="41" mass="4406" checksum="A2BB8EF26D002681" modified="2006-07-11" version="1">MLPPALLSAGGRTTLAPSLPGTDARTLTAMLRFDYDWDAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW78</accession>
    <name>Q1CW78_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557151.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7232"/>
    <dbReference type="ESTHER" id="myxxd-q1cw78">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88099">
        <property type="protein sequence ID" value="ABF88099"/>
        <property type="gene ID" value="MXAN_7232"/>
    </dbReference>
    <dbReference type="GeneID" id="41364400"/>
    <dbReference type="KEGG" id="mxa:MXAN_7232"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_7"/>
    <dbReference type="OMA" id="WGWQHAA"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="30610" checksum="66191BF7EB46AAEC" modified="2006-07-11" version="1">MPMLTVNRTDLYYEDSGGTGVPVVFSHGLLWSCRLFDPQVEALCGRYRCIAYDHRGQGQSAVPPARVIDMETVYLDAVALIERLGVGPCHFVGLSMGGFVGMRIAARRPDLLRSLVLMETSADREPLHNVPRYTLLNLTARLAGLRPVADPVMRIMFGRSFMTDPNRAEERSRWRTRLMENRRDIWRAVNGVIERRGVAHEIPHIRVPTLVVVGAEDTATVPAKAQRLHRLIPGSRLVTLPRGGHSSTVEEPALVNATLGTFLDAQLETRTSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW79</accession>
    <name>Q1CW79_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557150.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7231"/>
    <dbReference type="EnsemblBacteria" id="ABF90962">
        <property type="protein sequence ID" value="ABF90962"/>
        <property type="gene ID" value="MXAN_7231"/>
    </dbReference>
    <dbReference type="GeneID" id="41364399"/>
    <dbReference type="KEGG" id="mxa:MXAN_7231"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033631_3_1_7"/>
    <dbReference type="OMA" id="FHRWHHT"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="30168" checksum="9C280A977E1C3E43" modified="2006-07-11" version="1">MMSLEVLGGGAAISFGVLACVFWPLEKAWAARPGQPLLRPAFRTDLAYFVAQYLVLAPLALLMLSHVQALLHLDLLSGLQAAVARQPWWLQALEAVVLCDLLVYGFHRLSHQVDFLWRFHAVHHSAEHLDWLAAHREHPVDGLLTQLVVNLPAMMMGFPLGTLAMLIAFRGVWAIFIHSNVRLPLGPLGFLFGAPELHHWHHARERHTRHNFGNLAPWTDWLFGTYYRPTGPEQYPLGLVEPFPRRFWAQLLSPVTRATDSRNTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH4</accession>
    <name>Q1CWH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557055.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7136"/>
    <dbReference type="EnsemblBacteria" id="ABF86813">
        <property type="protein sequence ID" value="ABF86813"/>
        <property type="gene ID" value="MXAN_7136"/>
    </dbReference>
    <dbReference type="GeneID" id="41364310"/>
    <dbReference type="KEGG" id="mxa:MXAN_7136"/>
    <dbReference type="HOGENOM" id="CLU_088218_0_0_7"/>
    <dbReference type="OrthoDB" id="1722583at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="30686" checksum="52FAE534F4EC03B1" modified="2006-07-11" version="1">MFSDTLRNIQDDSLFGIEEAARSIQRQDASERSGQAYTIAALCHRRLAICAVLLDARPDRFLAHLCHSAHARLYFLRLVAGGHAAEPQYICASKEFSFIDAIAAGQYALSVDIAKLSARHHDPAHEYEDDFLLHHFLQQFFLKTIGATEASPTSLSALLDRWKTVLEDGEDNYLEACRALLEKQPLAFDEALQAIIDARLLTFQKMSRSSGPEEELRKTEGALFMNGLAMLRLAELQGMQTRSEYISIPSLSRIPAGQRAPTGAAWLVPQPDWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX60</accession>
    <name>Q1CX60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556819.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6899"/>
    <dbReference type="EnsemblBacteria" id="ABF88379">
        <property type="protein sequence ID" value="ABF88379"/>
        <property type="gene ID" value="MXAN_6899"/>
    </dbReference>
    <dbReference type="GeneID" id="41364082"/>
    <dbReference type="KEGG" id="mxa:MXAN_6899"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004089_0_0_7"/>
    <dbReference type="OMA" id="LTHHAFQ"/>
    <dbReference type="OrthoDB" id="982733at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187872" evidence="1">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="29537" checksum="251384255F6E7F8B" modified="2006-07-11" version="1">MKTPRIPICLPLVAVIGLLSACGPTPTTMKLEPLETKYLRTPGQTVKLAYEVFDAEGQPMSDPKLRWTSSAPDVAQVQEGLLTVRKSGKTTIGATGGKVRAALPLELTILNSLDVRAPGADFLEVGRVIKLRVVARNEQGSSLQDAMPTFRSSDEMVARVEDGQLVAVRPGKATLSATLGHLSRHIAVQVVPADFARLGLNLTHHAFQRRGQSVQLQARAFNRSGVVLDTVPLEFFTSDSAVVSVSPEGRVTAVGSGRAVVSVVAGRRRSAAEFVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX64</accession>
    <name>Q1CX64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556817.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6895"/>
    <dbReference type="EnsemblBacteria" id="ABF92745">
        <property type="protein sequence ID" value="ABF92745"/>
        <property type="gene ID" value="MXAN_6895"/>
    </dbReference>
    <dbReference type="GeneID" id="41364080"/>
    <dbReference type="KEGG" id="mxa:MXAN_6895"/>
    <dbReference type="eggNOG" id="ENOG5032IRR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396847_0_0_7"/>
    <dbReference type="OMA" id="GNSCNCC"/>
    <dbReference type="OrthoDB" id="137148at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026435">
        <property type="entry name" value="Myxo_Cys_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030819">
        <property type="entry name" value="Myxo_TraA_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04201">
        <property type="entry name" value="Myxo_Cys_RPT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04566">
        <property type="entry name" value="myxo_TraA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188003" evidence="1">
        <location>
            <begin position="37"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="719" mass="74907" checksum="9BFF395F16EB4000" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX99</accession>
    <name>Q1CX99_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556782.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6857"/>
    <dbReference type="EnsemblBacteria" id="ABF86438">
        <property type="protein sequence ID" value="ABF86438"/>
        <property type="gene ID" value="MXAN_6857"/>
    </dbReference>
    <dbReference type="GeneID" id="41364046"/>
    <dbReference type="KEGG" id="mxa:MXAN_6857"/>
    <dbReference type="eggNOG" id="COG2370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043645_2_0_7"/>
    <dbReference type="OMA" id="HIFIGLD"/>
    <dbReference type="OrthoDB" id="760572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032809">
        <property type="entry name" value="Put_HupE_UreJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13795">
        <property type="entry name" value="HupE_UreJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187874" evidence="2">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="373" mass="39608" checksum="A4706488051E709E" modified="2006-07-11" version="1">MSRVALLSLLLVSLSAQAQKPSDSYLRLTEADGQGVSGRWDVSLQDLDDVLGLDAGGDGAITWGEVLAREADIRSYVLGRLVLGSEGAPCALVSQGGLHIRQHSDGAYAVVDFDARCTGSAARLDVDYTLLFDHDPLHRGIVRVGAREPLIFSVSQHFARVHLRDESPWRTAERMTVEGALHVVTRPDHLLFLFALLLPSVLRRDVDGRWVAVSGFGTALWDVVKVVSAFTVAHALTLVAATLGWASLPPRFVSIAFALGILVAALDNVRPLGWGTRWTVAFVLGLLHGFGFASVLAGMGLSAGSLALALLGFNLGVELGQVAFVAALLPLAFVLRKAPLYRRAVVVGGSVAIALLACLWLAERALGLGVSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC3</accession>
    <name>Q1CXC3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556758.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6833"/>
    <dbReference type="EnsemblBacteria" id="ABF91010">
        <property type="protein sequence ID" value="ABF91010"/>
        <property type="gene ID" value="MXAN_6833"/>
    </dbReference>
    <dbReference type="GeneID" id="41364022"/>
    <dbReference type="KEGG" id="mxa:MXAN_6833"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1401169_0_0_7"/>
    <dbReference type="OMA" id="MEVQAIW"/>
    <dbReference type="OrthoDB" id="1643620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26056" checksum="4102B4E45BFAC96C" modified="2006-07-11" version="1">MGPICLPRRTVDRPGGAFAPLEDGRSSGLLGRRDDDARETEATRMSELSAEVRVQVARLRNLLIDVARCGALGSPLGALPHTELDPMEVQAVWWLKAESLLPVNVLAERLGGIAPPRLSRLLDRLEAAQLVQRERSVRHDRRRVRVRLTEQGRALAEQADAVVQERMARLLLPLEGEQRSALMDLLEGWVEALGGKNRAPELTTEGGETDAPVADELEPAAAPRRTHTELMAITANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY3</accession>
    <name>Q1CXY3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556548.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6622"/>
    <dbReference type="EnsemblBacteria" id="ABF90045">
        <property type="protein sequence ID" value="ABF90045"/>
        <property type="gene ID" value="MXAN_6622"/>
    </dbReference>
    <dbReference type="GeneID" id="41363820"/>
    <dbReference type="KEGG" id="mxa:MXAN_6622"/>
    <dbReference type="HOGENOM" id="CLU_1641894_0_0_7"/>
    <dbReference type="OMA" id="NKPLPPW"/>
    <dbReference type="OrthoDB" id="1763365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="17145" checksum="436603752EC81B35" modified="2006-07-11" version="1">MRERNIRRWGSAAALVAGAVLAVGCRGLPETGGSQPDEPRGSLVAQRGDQPDSMKNIEGGNTNKPLPPWTLPANRGYNGTIDQIGSSIDPRTPKNDGTQGRSIVDDAGKMMNDRYHVEGGAAYSPAAHGLGGEDGATLGGKRGGHHSGYSPLGWQDRSGPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY05</accession>
    <name>Q1CY05_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556526.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6599"/>
    <dbReference type="EnsemblBacteria" id="ABF91818">
        <property type="protein sequence ID" value="ABF91818"/>
        <property type="gene ID" value="MXAN_6599"/>
    </dbReference>
    <dbReference type="GeneID" id="41363798"/>
    <dbReference type="KEGG" id="mxa:MXAN_6599"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083619_0_0_7"/>
    <dbReference type="OMA" id="KGMATYR"/>
    <dbReference type="OrthoDB" id="1714516at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4142" evidence="2">
        <location>
            <begin position="104"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="29268" checksum="F7A8AFBD55FD0CA9" modified="2006-07-11" version="1">MGSATVIRHTLSSLCVKWRTDASSRTVHPAPTPLQRARPPFLTHKEQHPMKHPLPGLVLAASLFTQGASFAQSGMPDSPPSQQDTVSVQKGMATYRGYTAPTDEKALLDRLHLANQHEIKSGQLAQQRSQNPDVKAFGTIMMKAHTALDQKLTSYARSKGLKLAESPKPMNDAEEASMAKDKATMEQLQVIRGAPFDSAYLASQVTGHDAVLGMVLTAQKAMPKATPELAALLEDLSKQVPAHRHQAWNMLGKLGGETGVGGSGPAHAPPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYK9</accession>
    <name>Q1CYK9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat (Twin-arginine translocation) pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556322.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6390"/>
    <dbReference type="EnsemblBacteria" id="ABF91912">
        <property type="protein sequence ID" value="ABF91912"/>
        <property type="gene ID" value="MXAN_6390"/>
    </dbReference>
    <dbReference type="GeneID" id="41363601"/>
    <dbReference type="KEGG" id="mxa:MXAN_6390"/>
    <dbReference type="eggNOG" id="COG4102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032896_3_1_7"/>
    <dbReference type="OMA" id="FRSMDIW"/>
    <dbReference type="OrthoDB" id="663130at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="42997" checksum="A45C9250868082A6" modified="2006-07-11" version="1">MTAPLTRRHLLRALGATGAGLVCAPGFLGRALAASPVSAARRTLVTVFLRGGVDGLSLVPPIEDAAYHRARPSLALRASGPDAALKLSGPFGLHPRLDALMPLWHDGRLAVLHGVGLPEPVRSHFDAQDFVESGTPGRKSTPDGWLNRALDEEAGAALRAVALQPTLPRALFGDAGAVAMGRLEEFRLRGGRRGEEATRGFSALYAGAVDEALRTTGQGAFEAMSLLDEDRLAKLPSHAAVAYPKGPLGQRLRDIARLIHGEVGLEVAATESGGWDTHAAQGSATGAFANRCQELGSALSAFAADLGPRLEQVTVVVLTEFGRTVRENGSRGTDHGVGSAMLVLGGGVKGGKVYGRFDSLEPDHLQDGRDVPAWTDIRAPLAEVLLACRPGVELARVFPGFTPPPSLGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYT7</accession>
    <name>Q1CYT7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SsnA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssnA</name>
        <name evidence="2" type="ORF">MXAN_6311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556244.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6311"/>
    <dbReference type="EnsemblBacteria" id="ABF89828">
        <property type="protein sequence ID" value="ABF89828"/>
        <property type="gene ID" value="MXAN_6311"/>
    </dbReference>
    <dbReference type="GeneID" id="41363527"/>
    <dbReference type="KEGG" id="mxa:MXAN_6311"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_6_7"/>
    <dbReference type="OMA" id="QLAHVGH"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="430" mass="45580" checksum="5FFEF666340BEEBF" modified="2006-07-11" version="1">MGTVLKGGYVVELEPALVERVDLRIEGERIVARGPDLTPGPDDEVVALSGKLVFPGLVSAHHRLYAVLGRGMPRPPLETYQEILEQVAWPYENALDLDAVQVAGCAGGLEALQCGTTTVCDLHSSPKAISGSLVRLARGLHEVGVRGVLAYAVSDRQGALGREEGLEETVSFAKKAKGRFRGQVGAAPCFTIGPDALSGLAEALKALGDGGLHLPLAEDPLDERLSNENYGASPVSRLLEAGLLSPKSQLAHVGHLDWADLAQVIATGAWLVHTPRANQGLEVGYAPALKFGARATLGADGVSADLFAEAQAAYLRSREAGQPIDVLRYLANGHRMASQIFDASVGPMREGSLADLLILDYLPATPLTAENLAWHVVFGLGSRHVEAVMVDGVWRMWARRPLSVSPSVVAEQAREAASAVWARMAEAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU4</accession>
    <name>Q1CYU4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_6304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556237.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6304"/>
    <dbReference type="EnsemblBacteria" id="ABF90735">
        <property type="protein sequence ID" value="ABF90735"/>
        <property type="gene ID" value="MXAN_6304"/>
    </dbReference>
    <dbReference type="GeneID" id="41363520"/>
    <dbReference type="KEGG" id="mxa:MXAN_6304"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_7"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="14"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="337" mass="36545" checksum="F06036ABA59FD3BB" modified="2006-07-11" version="1">MPQLGPYTLPNPYILAPMAGVSEMPFRVLAFRLGAALCPTELVSSQGLMRANQRTLKYLRYDAEVERPYSLQIYGGEPEAMARAAVVGREAGAQIIDINMGCPVKKVVKNGAGSGLLCDVPRAADIVRRIREATGLPVTCKIRSGWDARSLNYLQVAGALQEAGCAGLAIHPRTREQGYSGQADWSVIADLKRHFPELPIIGNGDVKTPADAARMLETTGCDFVMIGRAALGNPWIFRELLGGPPATPRERCELVLEHFRAHLDFMGDPLGAVRSFRKQLAWYAHGLYGAAAFRAEVNGLDLPSAVEDCVRRFFAAAHVDLAGPGEEQDVDYRAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ73</accession>
    <name>Q1CZ73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556113.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6169"/>
    <dbReference type="EnsemblBacteria" id="ABF87444">
        <property type="protein sequence ID" value="ABF87444"/>
        <property type="gene ID" value="MXAN_6169"/>
    </dbReference>
    <dbReference type="GeneID" id="41363399"/>
    <dbReference type="KEGG" id="mxa:MXAN_6169"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_1_0_7"/>
    <dbReference type="OMA" id="NWGHEDI"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="3">
        <location>
            <begin position="147"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="39019" checksum="3AA98AE18B617675" modified="2006-07-11" version="1">MHAVAVFPGTREVRLVDPPEPRPVTGSQVLLKVLEVGICGTDREIGAFEYGTPPPDSDHLILGHEALAEVVETGPDVTLVREGDLVVPTVRRPCPHARCRPCRAERQDFCVTGDFRERGIKAAHGFLQEWVVEEEGHLVVVPRKLSDVAVLVEPLSVAAKAAEQVQAIQRRLPWERARVRALALGAGPVGLLGAMSMVVNHFDTFVYSLEPAASERANLIRSFGATYVSGQDVLLGELGKKVGTFDIIYEAVGMSKVAFAALDALGPNGLFIFTGIPAHGGPNPVDTDTLMRNIVLRNQLLLGTVNASRSAYELALRELEQAMFLFPQSVRALITHRVPIQEAPALLTESGGIKQVVQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ86</accession>
    <name>Q1CZ86_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c biogenesis protein/thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556100.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6156"/>
    <dbReference type="EnsemblBacteria" id="ABF90574">
        <property type="protein sequence ID" value="ABF90574"/>
        <property type="gene ID" value="MXAN_6156"/>
    </dbReference>
    <dbReference type="GeneID" id="41363385"/>
    <dbReference type="KEGG" id="mxa:MXAN_6156"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690096_0_0_7"/>
    <dbReference type="OMA" id="HTPEYPW"/>
    <dbReference type="OrthoDB" id="1957419at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="269"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="40119" checksum="F8D22A43B22562A6" modified="2006-07-11" version="1">MSLGLPGIFLAGLLTFLSPCVLPLVPLYLSFLAGVSLSQLREAGSGVRRPWGVALAFSLGLGSVFVALGMAATAMGGLLAEHRSGLLQFGGLALFLLGLKQLGFIQIPWMDGEVRPLLGRVRRGGSLLGAFLFGAAFALGWTPCIGPVLGGVLTYTASSTSEPLMGALYLGTYAAGLSVPLLLVAAAAPLALRWMERAKRHLRKFEVATGVLLAGLGVLLFTDSLELLVPSAEGGEASAPVMERRASSSPAASETACTSEEGGDGTCALPEEGGVPSFIGPSALARVERPTMVEFVSQSCPVCQRMEPTVALAEQHCSGKGVEVLRLDVGTAAGRRAAVQYGVRGVPTFLFLDAAGQEVARRVGEQSLTSLWQGLEVIAGGRCAGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZP8</accession>
    <name>Q1CZP8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555939.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5990"/>
    <dbReference type="EnsemblBacteria" id="ABF92204">
        <property type="protein sequence ID" value="ABF92204"/>
        <property type="gene ID" value="MXAN_5990"/>
    </dbReference>
    <dbReference type="GeneID" id="41363229"/>
    <dbReference type="KEGG" id="mxa:MXAN_5990"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616528_0_0_7"/>
    <dbReference type="OMA" id="RMNAEMI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="225"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="48100" checksum="24D093FF09766B78" modified="2006-07-11" version="1">MKAPRSPAGDDSAHPDVPASRRRPRRAWRKRGQAHRHLAQLHEVGQLLCASEGVAASFPALVDRLSRWLPVRVALLLEGVDASGVPVPERPCLMAWHSSVGMESPPSQAVAHAASAYAYLVGLERVTLQGRDVIEGVFKAEPARVPGVVTLPLVAKEGVLGVLHVESVGLGEDGLVLLDAVANLLAVALPKEHVLRREVRRRERAEALFFQAQEAVRWRDELLTVVSHDIKTPLLAVRMNAEMILNAGTAPEKEHRRRRYLENIVLAEQQMSSLIGNLLDRARLRGMPIPLTLQPLPVDALLAQSLEVLRPLALEKGQVLTVAQAPELPPVLADRERILQVLANLVSNAIKFTPPGGVIEVRARLVEGAKVCVFVKDSGPGIPAEDAPHLFERFWRASHSPGRGTGLGLSIAWSLVAAHGGTLNVESHEGQGSTFSFTLPVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D054</accession>
    <name>Q1D054_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555783.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5832"/>
    <dbReference type="EnsemblBacteria" id="ABF88290">
        <property type="protein sequence ID" value="ABF88290"/>
        <property type="gene ID" value="MXAN_5832"/>
    </dbReference>
    <dbReference type="GeneID" id="41363072"/>
    <dbReference type="KEGG" id="mxa:MXAN_5832"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140995_0_0_7"/>
    <dbReference type="OMA" id="FGRIRFL"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="18033" checksum="18E5135CB84803C0" modified="2006-07-11" version="1">MSTGPASPSLPAGDDADRRALEDVVRAFTDAFNRDDLDAVMAYFTPDAMYETYDGKLCRGLAQVREAFAAQFRGDFGRIRFLTEDMVVDAPAGKVVLRWRCQHEVSARRGPRQLMYRLMYGQHFGWYGLDVLHWEAGRLREKRTYAQAGLPLVRRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C4</accession>
    <name>Q1D0C4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555713.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5762"/>
    <dbReference type="EnsemblBacteria" id="ABF91709">
        <property type="protein sequence ID" value="ABF91709"/>
        <property type="gene ID" value="MXAN_5762"/>
    </dbReference>
    <dbReference type="GeneID" id="41363005"/>
    <dbReference type="KEGG" id="mxa:MXAN_5762"/>
    <dbReference type="HOGENOM" id="CLU_1553632_0_0_7"/>
    <dbReference type="OMA" id="YNYSFVI"/>
    <dbReference type="OrthoDB" id="1419157at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187954" evidence="1">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="19204" checksum="685E7EE520140A42" modified="2006-07-11" version="1">MVRMRWPRWTVVGLGLLVAAGCRTTSASAQGPARPKWMPPEGTCPRGALLQMERLGLKPGDKVPVIVDAIQDHPGPARYNYSFVIALPREQGEQQLPGARIGGRLYVTKHRVFGRYDRIFLPESGAMSVPFCGILLDSRWDKDGEGLIAYPSPMKGFSVVQDNTGVIQVVDRYP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D0</accession>
    <name>TOLB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tol-Pal system protein TolB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tolB</name>
        <name type="ordered locus">MXAN_5756</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555707.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0D0"/>
    <dbReference type="SMR" id="Q1D0D0"/>
    <dbReference type="STRING" id="246197.MXAN_5756"/>
    <dbReference type="EnsemblBacteria" id="ABF89846">
        <property type="protein sequence ID" value="ABF89846"/>
        <property type="gene ID" value="MXAN_5756"/>
    </dbReference>
    <dbReference type="GeneID" id="41362999"/>
    <dbReference type="KEGG" id="mxa:MXAN_5756"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047123_2_0_7"/>
    <dbReference type="OMA" id="VREPSWG"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00671">
        <property type="entry name" value="TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014167">
        <property type="entry name" value="Tol-Pal_TolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007195">
        <property type="entry name" value="TolB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04052">
        <property type="entry name" value="TolB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02800">
        <property type="entry name" value="propeller_TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000259058" description="Tol-Pal system protein TolB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="431" mass="46035" checksum="E4DB225E387F8648" modified="2006-07-11" version="1" precursor="true">MKALLLSLLLLLPVVALAQAPTIEISGANFRPLPVAVPAPLTQNDGAKALVAPFDSAFSFDLTASGILQVLDRKGFTADAKEGMAAASINFSRWADVGAEALVKVSLAQDGGVLRGELRLFNVGTGREDLKVSKDAPADNASLLAHRLADALYRHFTREPSPFLSRITYVRKAGTNRDVYVADWDGGNARALTKGGINILPALSQDGSQVAFTTYRKNRPDIYVQSPGGEAKAVISGGQMATGAAFSPDGKRIAYSLAEGESAQVYVANADGSGARALTDTPYGLNTSPTWSPDGKRIAFVSNRGGSPQVYIMNADGTGVRRLTFQGNYNQTPDWSPRGDLIVFTARDERNAFDLFTVSVETGKVTRLTQDQGSNEEPAFSPNGRLIVFTSTRNGGSQLYVMTADGNNQLPLRTEKGTYQTPDWSPLPQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D9</accession>
    <name>Q1D0D9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_5747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a membrane-associated complex with FtsE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555698.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5747"/>
    <dbReference type="EnsemblBacteria" id="ABF87980">
        <property type="protein sequence ID" value="ABF87980"/>
        <property type="gene ID" value="MXAN_5747"/>
    </dbReference>
    <dbReference type="GeneID" id="41362990"/>
    <dbReference type="KEGG" id="mxa:MXAN_5747"/>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073546_4_1_7"/>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="11">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF87980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="31065" checksum="5D7BC1C2AC0B9D56" modified="2006-07-11" version="1">MSALSKVTYFCRSAAVGLKHSPFVHFIAVTTIAIALFSAGMARGAARVLDNLLASLGGEVEVTVYLSPELDADEVHGVRALVLALSGGEVTLVSPDAALSRLRTELGDLGEALAELPENPLPVSLELRVPPERRNPDALLALAKALRAAPGVAGVDYGEAAVQRLSAIARALRFGSLVAFAVVLGATVVIVAATLQLAIYSRRGEIEIQKLVGATDRFVKAPFLLEGLLQGVLGAAVALFGLWAFGRVLGPTLGALFAFLLGPGVAAPWVEPRLALELLCAGCGLGLGGSFVAVGRFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0L3</accession>
    <name>Q1D0L3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5672"/>
    <dbReference type="EnsemblBacteria" id="ABF87112">
        <property type="protein sequence ID" value="ABF87112"/>
        <property type="gene ID" value="MXAN_5672"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5672"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="CDRNISR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="223"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="537" mass="58566" checksum="EE45CB5655EFD0E2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D167</accession>
    <name>Q1D167_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555421.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5463"/>
    <dbReference type="ESTHER" id="myxxd-q1d167">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90520">
        <property type="protein sequence ID" value="ABF90520"/>
        <property type="gene ID" value="MXAN_5463"/>
    </dbReference>
    <dbReference type="GeneID" id="41362719"/>
    <dbReference type="KEGG" id="mxa:MXAN_5463"/>
    <dbReference type="eggNOG" id="COG0429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_0_0_7"/>
    <dbReference type="OMA" id="YGHTDDY"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="358" mass="39943" checksum="63CC7CA573A5F402" modified="2006-07-11" version="1">MAEHANAFHVPWWLRFSHVQTVVPHLDRRRHDVLTEHIRHELADGDFVDVYWLNRTRPGPLLILLPGMQGTQDSTYVRSLLSELSPRGLRAAVLCHRGGAVPNRRAPFYHAGFTDHLAWLVRFVREQEPHTPLYGVGFSLGGSMLIRYLAETGHASHLSAAAAVSLTFSLGSTARRACEGINQLYQLRVLNSYKRVARLKAHLPEFASRVGTLNGMRSIQAFDEVFTAPLHGFKDAEDYYERCSSQQFLPGIEVPFLVLNAEDDPLVARDTLPDARALREHVRLELTPHGGHLGFMYQRSSGLGYYPPARLISFFLQEPSEAHESLSQDVVGHALLALEAGDARGRADEHAGAARPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D193</accession>
    <name>Q1D193_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S1 (Chymotrypsin) family</fullName>
            <ecNumber evidence="4">3.4.21.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555395.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5435"/>
    <dbReference type="EnsemblBacteria" id="ABF91256">
        <property type="protein sequence ID" value="ABF91256"/>
        <property type="gene ID" value="MXAN_5435"/>
    </dbReference>
    <dbReference type="GeneID" id="41362696"/>
    <dbReference type="KEGG" id="mxa:MXAN_5435"/>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_7_3_7"/>
    <dbReference type="OMA" id="APAMYTR"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="55"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="36036" checksum="9333E482678592E7" modified="2006-07-11" version="1">MRHGMWLAVGMCLMSKEGALRFVSGVIVAVSLLGCGGPELERQDVEATGRMDQAIVGGVEARPGSHPWIVSLQQYNDHFCGGSLIRVGNKEESDIVVTAAHCVYDGTSGLTVVAGAHDFNRPSSSQQAVVARKTVYHPEYNPDTTANDVAVVVLDKPIKFTSTVQPVCLPEDSFSVSGASCGKSSVVMRPNLVAKSPLAETSLSPVGLSSVGADVPDGTMMVTAGWGLIREGGYDTSSILMQVWVPTVNSETLKTAYKKEGITIDPNVMLGAGYMSGGKDSCQGDSGGPLVAQVGGRYVLYGITSFGVGCARPGFPGVYARVSEFRSWINTQVKDNSRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1A2</accession>
    <name>Q1D1A2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555386.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5424"/>
    <dbReference type="EnsemblBacteria" id="ABF86095">
        <property type="protein sequence ID" value="ABF86095"/>
        <property type="gene ID" value="MXAN_5424"/>
    </dbReference>
    <dbReference type="GeneID" id="41362686"/>
    <dbReference type="KEGG" id="mxa:MXAN_5424"/>
    <dbReference type="eggNOG" id="ENOG50329HZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_4_1_7"/>
    <dbReference type="OMA" id="CKEPFTE"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="58" mass="7020" checksum="FCD86DBFABAACB6A" modified="2006-07-11" version="1">MPVYEFYCRKCKEPFTEIMSVKEHDERTPKCPRCQETKEVEKRISTVHTVTTKKWLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1C3</accession>
    <name>Q1D1C3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5403"/>
    <dbReference type="EnsemblBacteria" id="ABF89508">
        <property type="protein sequence ID" value="ABF89508"/>
        <property type="gene ID" value="MXAN_5403"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5403"/>
    <dbReference type="HOGENOM" id="CLU_2356798_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10942" checksum="41AFBC835773049F" modified="2006-07-11" version="1">MGRPPGAAPFICCPAMLRGHETLARQQRLRWTEVDVRPPPNKQARCALLEGFSLHANTLLHANDRQGLERRCRYGRAVRWRWSGCHERRTAASPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1D6</accession>
    <name>Q1D1D6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555352.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87573">
        <property type="protein sequence ID" value="ABF87573"/>
        <property type="gene ID" value="MXAN_5390"/>
    </dbReference>
    <dbReference type="GeneID" id="41362657"/>
    <dbReference type="KEGG" id="mxa:MXAN_5390"/>
    <dbReference type="HOGENOM" id="CLU_2465806_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="88" mass="9282" checksum="DD930958263F80B5" modified="2006-07-11" version="1">MFKSMILAVAVLGLTACGSDDSEQSAECKKYLACIKATTPEFQATAEVTYGADGSCWNSDETARVCTAACTDGLTQLRGHHPDESACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1S8</accession>
    <name>Q1D1S8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555210.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89695">
        <property type="protein sequence ID" value="ABF89695"/>
        <property type="gene ID" value="MXAN_5243"/>
    </dbReference>
    <dbReference type="GeneID" id="41362522"/>
    <dbReference type="KEGG" id="mxa:MXAN_5243"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_617796_0_0_7"/>
    <dbReference type="OMA" id="VAHTEVC"/>
    <dbReference type="OrthoDB" id="989109at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="47037" checksum="023B6B9B3358C896" modified="2006-07-11" version="1">MNSDQLRRLFARALSASLASPLLLTGCGSGDISLEGYTSPTCDNGRLSVRGLSPATQTDFVAMKLIADLYTTPRQQTLVSSGTPCETATQPVACNAELEALSSEEGFRSRCDPDCYAFYLVTTRGDAVEAHTSQEALQAFLGDIDTSQEALLQVFAGGYDLSCTELEKGAVKANADGTFNVVASKGFACGEGSNLTQYLLEVTPSGEVHVKQTRILERGTKGCTVGRRPAGLRSDGSIACADELGQHFALIAHLEEASITAFLRLRDELALHGAAVELQQAALRSALDEVAHTEVCGRLARRHGATPARAVVAPLPPRPLNEVALDNAVEGCVRETYGALLAHHQALHAEDDEVREAMVRIAEDETRHADLSWAIDRWAVERLPSAEQEAVRAARQRAVAALREEVSAPTDAALLRALGLPEPEVAVAMVDLLSRELWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T5</accession>
    <name>Q1D1T5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5236"/>
    <dbReference type="EnsemblBacteria" id="ABF88295">
        <property type="protein sequence ID" value="ABF88295"/>
        <property type="gene ID" value="MXAN_5236"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5236"/>
    <dbReference type="HOGENOM" id="CLU_457717_0_0_7"/>
    <dbReference type="OMA" id="EVRCFLW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="66499" checksum="7589BC805EB59201" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D276</accession>
    <name>Q1D276_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555067.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5093"/>
    <dbReference type="EnsemblBacteria" id="ABF91733">
        <property type="protein sequence ID" value="ABF91733"/>
        <property type="gene ID" value="MXAN_5093"/>
    </dbReference>
    <dbReference type="GeneID" id="41362377"/>
    <dbReference type="KEGG" id="mxa:MXAN_5093"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101666_0_0_7"/>
    <dbReference type="OMA" id="AWARGPM"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="24377" checksum="D4098C49C7A681A6" modified="2006-07-11" version="1">MKPWETLERAEVPDVGEVTLARRGDEYVFRVRGQTLMSSRQHGSEEALAEAGCEGLAGRSGVRVLVGGLGFGYTTRAVLDRLGPDARVTVAELLPVVVTWNRGLLAPLAGAPLEDPRVTVVELDVGKHMARQSGTYDAILLDVDNGPTALTHPDNHGLYGRVGLAHAVQALRPGGVLGVWSAGPSPAFERRMEQAGFTVQVLHPAAHGTKGTRHTLFMGKRRPQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D279</accession>
    <name>Q1D279_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555064.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5090"/>
    <dbReference type="EnsemblBacteria" id="ABF90582">
        <property type="protein sequence ID" value="ABF90582"/>
        <property type="gene ID" value="MXAN_5090"/>
    </dbReference>
    <dbReference type="GeneID" id="41362374"/>
    <dbReference type="KEGG" id="mxa:MXAN_5090"/>
    <dbReference type="HOGENOM" id="CLU_1299126_0_0_7"/>
    <dbReference type="OMA" id="EMANFYE"/>
    <dbReference type="OrthoDB" id="1815641at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="22896" checksum="FC076F9ECB7CA358" modified="2006-07-11" version="1">MKHSSRKGLPGGVRFAAIVGLVLSILTGWAALMEAVEMANFYEARSLRMEQELPRIPGAPALDPKILEVYYAALEPMREPRAVLLGLLAVACAFVSVSAARMLSPENLHRDALSRVLSRAAIIAAGLRTIDGAQMSVAKQRLFAALAEPMSKMPEFPPDITVEASREILSAMGVGSAIFGTVVVAGTFALLGQYFRSQRVREAMAVQDGPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2B8</accession>
    <name>Q1D2B8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555026.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5050"/>
    <dbReference type="EnsemblBacteria" id="ABF88056">
        <property type="protein sequence ID" value="ABF88056"/>
        <property type="gene ID" value="MXAN_5050"/>
    </dbReference>
    <dbReference type="GeneID" id="41362334"/>
    <dbReference type="KEGG" id="mxa:MXAN_5050"/>
    <dbReference type="HOGENOM" id="CLU_132063_0_0_7"/>
    <dbReference type="OMA" id="PVRAMED"/>
    <dbReference type="OrthoDB" id="1881422at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="19198" checksum="CCC83A9F72FB1CD5" modified="2006-07-11" version="1">MDALLPVTPTEVFVTLLFGAIFLYATWVIGSFTRDAMVERDVLKHGEDAEATVLELRDTGLRVNRRPVFELLLEVRQRGRASYQARVRKRLGPHQSVGSLGVGMRLNVKVDRAEPSKVAIVGAAMTAPVGAFVLQGMPSAGDPVKAMQDLQSLMDKGLITPEEFEVKKAQILARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D7</accession>
    <name>Q1D2D7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, HAE1 family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5031"/>
    <dbReference type="EnsemblBacteria" id="ABF91110">
        <property type="protein sequence ID" value="ABF91110"/>
        <property type="gene ID" value="MXAN_5031"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5031"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_4_7"/>
    <dbReference type="OMA" id="DGHSRLM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="51"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="377" mass="39672" checksum="FDBF057AF3BD315F" modified="2006-07-11" version="1">MWGVTLLAVVAGCSAQKAAPPAPPPREVEIVTLTPREVRETGEYLGSLMSRQSVNVLPQVAGYVRKIHVRPGDKVEAGAALIEVDSREGTAALDSAQAQLSSTQVSLELARRTLERTEALYKEGLASAQELEQGRAQVEAAQAAARSSAAQVTQRQVQLQYHVVRAPFAGTMGDVLVRLGDYVGMTTPLTSVAQSDVLEVSVSVPSPRARSMKPDTALEILDSTGKVLITSNVFYIAPQADPRTQLVEVKAAFRNTVGLRPSELVRARLVYSARDALQIPALAIVRQSGQPFALVVLAKDGKTVVERRPITLGALGEMAYVVESGLQSGDQVAVSSLQALRDGMAVKPKQANAPNAPTGSGPPRASGNGGGTVGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2N9</accession>
    <name>Q1D2N9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554906.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4928"/>
    <dbReference type="EnsemblBacteria" id="ABF90760">
        <property type="protein sequence ID" value="ABF90760"/>
        <property type="gene ID" value="MXAN_4928"/>
    </dbReference>
    <dbReference type="GeneID" id="41362213"/>
    <dbReference type="KEGG" id="mxa:MXAN_4928"/>
    <dbReference type="eggNOG" id="COG2930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1174415_0_0_7"/>
    <dbReference type="OMA" id="FRKSEGW"/>
    <dbReference type="OrthoDB" id="1808930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25015" checksum="BF4BF2C6C058A0B0" modified="2006-07-11" version="1">MAVATLIHQEANMKPEQEKTLHEEVVATVDRLVLKHPELKKELEQVQGYAVFPSLGRASLVLGGSYGHGEVFEKGKPIGFATLSQLTLGVQVGGQTLSELIFFEDRDAIEAFKGGKAAFAANASAVIVKAAASGTINYAKCVAHAYSRGGMLLEASLGGQKFTFIPRSSGASERGNGGLVQRFRRQDASEENGADDTGQRSRLQASQPPPALTTGLTAAALLLTRIIKAQASARHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D9</accession>
    <name>Q1D3D9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554660.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4668"/>
    <dbReference type="EnsemblBacteria" id="ABF88093">
        <property type="protein sequence ID" value="ABF88093"/>
        <property type="gene ID" value="MXAN_4668"/>
    </dbReference>
    <dbReference type="GeneID" id="41361968"/>
    <dbReference type="KEGG" id="mxa:MXAN_4668"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007708_0_0_7"/>
    <dbReference type="OMA" id="YDLAFED"/>
    <dbReference type="OrthoDB" id="816455at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025634">
        <property type="entry name" value="DUF4292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14125">
        <property type="entry name" value="DUF4292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="30531" checksum="2B4678E8282D6472" modified="2006-07-11" version="1">MNRAAVAIFLVVLCSGCPKRIEFGPEGELTDADTVYQRVVKNQENVVTLEGDAKLRAELPDQSGTLSMFIAVTRPAMLHLETFDFFNRPLASLVSDGQRFGLYQADTNTWYQGPASPANVSRFLPVMLPGEELVPIMLGQVPLIPPERMTLELDRKKGVYVLTLHRGQATQVLDVHTKYLRIMKSQVRGIPGYDLGFEDFLEQGGLIFPGRVSLEAKQAKTKLQVRYQQIKLNARPDLTLYELVPPEGARVVEVDEAGRELPAGAPASGSSAPLAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3N5</accession>
    <name>Q1D3N5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554565.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4570"/>
    <dbReference type="EnsemblBacteria" id="ABF91126">
        <property type="protein sequence ID" value="ABF91126"/>
        <property type="gene ID" value="MXAN_4570"/>
    </dbReference>
    <dbReference type="GeneID" id="41361871"/>
    <dbReference type="KEGG" id="mxa:MXAN_4570"/>
    <dbReference type="HOGENOM" id="CLU_1174413_0_0_7"/>
    <dbReference type="OMA" id="HPYEDGA"/>
    <dbReference type="OrthoDB" id="1006505at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26530" checksum="5B24B76C8499316D" modified="2006-07-11" version="1">MMARETFSVVEVNPAHRFARLRPESGGPLLHAGLYPEEEAPEPQLQLREGDRVEGQRRGQSVADWGWVSRAEPPADLVERMGELLAKLEKYELRVPATAYDLAEHHWRQSRANPLHLELLAQLPTFFDWELSHPYEDGALLERLQAAMQPYLPGFEVTPQPGRAAFRLEPGGHDVSAPEGSREAPVSTFEPLLLQVNRLLEGAGAPVRWVPTEDDWILAPPGLAELLVLHGVLGSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D420</accession>
    <name>Q1D420_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554431.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4432"/>
    <dbReference type="EnsemblBacteria" id="ABF87107">
        <property type="protein sequence ID" value="ABF87107"/>
        <property type="gene ID" value="MXAN_4432"/>
    </dbReference>
    <dbReference type="GeneID" id="41361744"/>
    <dbReference type="KEGG" id="mxa:MXAN_4432"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="LCRRMKQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="134"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="35733" checksum="49B796133CBF9BF4" modified="2006-07-11" version="1">MSLVLVADDEPAVLEVLSQVVEDLGHDVLRARDGEEALGLARARHPQLVVTDHMMPRLSGVELCRRMKQEAQLKDVPVILLSAVLPQGAPEAFAFLHKPFEITDFESVIHKSLAASPEPRMAHAASPVGALGQWVAQTLQGPLETAREQLRRLECTPSVDRAALDTLAAQLQSMEAVGRHLRELAWLSSGEATLARIDTDVGQHLRDAVAAHGAHVTLEAPEEPVHAQVDPPRIRQVFDVLLANAVRQGDAEVALEISQTQLTVRVKDVGPGVAAEALAHLFTPFRMDAKGVRGPELYVASELVRLQGGALSVQSRPGEGSTFSLMLPRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4V4</accession>
    <name>Q1D4V4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator FrzZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">frzZ</name>
        <name evidence="4" type="ORF">MXAN_4144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Field C."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <location>
            <position position="52"/>
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    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
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            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="30485" checksum="4BA809523EBB8041" modified="2006-07-11" version="1">MSRVLVIDDSPMLVELTVRALTAAGYQASGAQDLASLELKLAEGPFSLILMDVNMPEMFGDDVVEYLRRQKKVTAKLVLYSDISEAELDGKTKASGADGYILKSGGLEAVLGGVMGLIGPPALSIPTAVPAPAAAPAAAPTPPPAPAAPAPAATGGLKPAPTTGGRKPRILIVDDSEMTARIIEADLVTKGFEVHVADTADKATKIILKKQTRPDLVLLDVRMPNVNGEQFCRFIKSNSLFKGIKVLLCSGENVEELQRICREAGADGYIPKDAVMGNLVAKELMPTGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Histidine kinase</fullName>
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    </protein>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
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    <dbReference type="EnsemblBacteria" id="ABF89991">
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        <property type="gene ID" value="MXAN_4140"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="project" value="CACAO"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="270"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
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            <end position="645"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="212"/>
        </location>
    </feature>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
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            <end position="180"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="777" mass="83190" checksum="9912BD40991C69E5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D554</accession>
    <name>Q1D554_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_4040"/>
    </dbReference>
    <dbReference type="GeneID" id="41361371"/>
    <dbReference type="KEGG" id="mxa:MXAN_4040"/>
    <dbReference type="eggNOG" id="COG0457">
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    </dbReference>
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    <dbReference type="OMA" id="VCEYSAH"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="28293" checksum="55FD4C6B3322686D" modified="2006-07-11" version="1">MPWRGTSTRVRRLSTRKRLRTPVWRHMHPALPLLLLALTGAASTPNARGLNTQGFRLYQAGRYPEALERFQASARESPDYALAHYNLAATLGMLRKQGKVCEYSAHRDVIVEHLTQAVKLDARRLTRAKEDADFTPIRDTLGWQKLLGRSPAREADVPVLLREVSWFGPGVGVYGTTQGLRFGPSGRVTLWTKEVGDDGTPRQKETRGRYTVRGRQVALRLNGRAPLEGTLTESGALTFPGLETFTDSPSECEA</sequence>
</entry>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="857" mass="94878" checksum="63DBFF4A4FD7C0AB" modified="2006-07-11" version="1"> </sequence>
</entry>
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    <name>Q1D5G0_MYXXD</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="1865"/>
        </location>
    </feature>
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            <end position="2935"/>
        </location>
    </feature>
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        <location>
            <begin position="4356"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
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            <end position="448"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="4503"/>
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        <location>
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            <end position="4352"/>
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    </feature>
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        <location>
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            <end position="4482"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="2895"/>
        </location>
    </feature>
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        <location>
            <position position="4393"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF92489.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5H9</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
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    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="442" mass="47690" checksum="0EC0F991096839F1" modified="2006-07-11" version="1">MRTFRNILFWIHLIVGIATGLVIAIMSFTGVVIAFEKQLIEWAERDVRTVQSPSPGAPRLPVEELVERVRAARTDGQPSGVTVYPEPTSSVLVSIGRGSVTYVNPYTGEVLGNGATGLRGFLQWNVELHRWLAAGGDNRAVGKAITGASNAVFLFLAISGLYLWWPRKWTLRAMRPSLWFRRGLKGKARDWNWHNVIGFWSLPVLIVLTASGMVISYKWASDLVYTVMGHEAPARQGPPGSATMKVPAPGVETPRKPMDVVIAEAQKTSPTWSSATLRLGSGARPGGAPAQGGRGPDAKGERGEKGGAAPAQGGRGPEAKGERGGKGGADGVDAVTVTLREADAWPLFSSKQVSLNPFSGEVAKQETYADYNSGRKLRTWLRFLHTGEALGLMGQLVAAIASLGGVFLVYTGFALSWRRFFSRRRTNTEPREEAAAQSEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5S6</accession>
    <name>Q1D5S6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter, major facilitator family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553827.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3815"/>
    <dbReference type="EnsemblBacteria" id="ABF89815">
        <property type="protein sequence ID" value="ABF89815"/>
        <property type="gene ID" value="MXAN_3815"/>
    </dbReference>
    <dbReference type="GeneID" id="41361147"/>
    <dbReference type="KEGG" id="mxa:MXAN_3815"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_7"/>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="OrthoDB" id="460405at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="45615" checksum="AAF41416C2165AD7" modified="2006-07-11" version="1">MARDGPVDYSAASMTHQAAASGLSIFQHRDFRFYLLARLCAVLAVQIESVAIGWQVYELTGSALALGYTGLAQFLPFLSLCLVGGQVADRVDRRTILAVCQTVMLVCSLLLLAFTLGHIRDVRFVYGVLVLFGAARAFHAPAGSALTPHLVPPEHLTRAVAINSTTWQVATIGGPAVGGILYGWIGAAGAYTASATLCALSVIWILILKVRTGRASAEPLSLSTLVAGLGFVRRQRLLLGSITLDLFAVLFGGAVALLPIYARDILHTGPWGLGLLRCAPAFGAAVVAVFLAMRPMGGNTGRKMFIAVAIFGAATLVFGMSRSLPLSLAALAIAGAADMISVVVRHTLELMATPDDMRGRVGAVNMMAIGASNELGEFRAGGFAEYLGAVPAVVAGAVGTLAVVALWAWAFPELRRVDRLESFARTKEPPATPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U6</accession>
    <name>Q1D5U6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA</name>
        <name evidence="9" type="ORF">MXAN_3795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553807.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3795"/>
    <dbReference type="EnsemblBacteria" id="ABF85856">
        <property type="protein sequence ID" value="ABF85856"/>
        <property type="gene ID" value="MXAN_3795"/>
    </dbReference>
    <dbReference type="GeneID" id="41361126"/>
    <dbReference type="KEGG" id="mxa:MXAN_3795"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="NMATWML"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF85856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="40991" checksum="AA502FDDE84444A6" modified="2006-07-11" version="1">MNLELTETQTLIRDTARKFARERVAPLARTLDREERFPTDLFRQLGEMGLLGVNLPARYGGSEAGVVAYALAMMEMAAADASTSVAMAVTNMCGELINAFGTDAQREKYVTRLASGEAIAGSFALSEPHAGSDPGALRTTAVRRGDVWVLNGSKQWITSGAYAGVMVVWARTSPAGNKGLSCFIVEGGTKGLIIGKHEDKMGLRSSNTVSLTFEDCEVPAENLLGAEGQGFKLAMVALDGGRIGIAAQACGVGRAALEATVAYVKDRQAFGQPIGEFQGPRFMLADMQTQLEAAELLTLRAASMKEKGQPFSREASMAKLFASEMSNKVADKAVQLHGGYGYIDEFPVERFFRDARVQTIYEGTSEVQRMVIARESFKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S3</accession>
    <name>Q1D6S3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting chemotaxis protein (MCP) signaling domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553486.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3453"/>
    <dbReference type="EnsemblBacteria" id="ABF92699">
        <property type="protein sequence ID" value="ABF92699"/>
        <property type="gene ID" value="MXAN_3453"/>
    </dbReference>
    <dbReference type="GeneID" id="41360801"/>
    <dbReference type="KEGG" id="mxa:MXAN_3453"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394235_0_0_7"/>
    <dbReference type="OMA" id="HWRRRML"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="451"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="737" mass="78679" checksum="300B2CCD7A67EFC5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S9</accession>
    <name>Q1D6S9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553480.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3447"/>
    <dbReference type="TCDB" id="2.A.6.1.9">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86953">
        <property type="protein sequence ID" value="ABF86953"/>
        <property type="gene ID" value="MXAN_3447"/>
    </dbReference>
    <dbReference type="GeneID" id="41360795"/>
    <dbReference type="KEGG" id="mxa:MXAN_3447"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679393_0_0_7"/>
    <dbReference type="OMA" id="FERGHRE"/>
    <dbReference type="OrthoDB" id="1772941at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="42785" checksum="D61E68BBEAD40324" modified="2006-07-11" version="1">MRGMWVLLVTLLAAAPARESPPLTFAESQSLAAKAALPASLARAVETRRVWDARLPWLAANPTLSVVPGRRAQPEGPGFELTVSVEQPLFLSNLAGAQRDAASAETRALEREAVAALLNRRLEVARAWLTLWSAQQAAATAEQEATLAGALRTSVADALALGGATRLELAEAEGFEAEAQVALLAREAEVTHARLSLAVLVGRQPDAHLVVAEALPEVALPPSSEEARWLARASELPDAEARRLLGVAERARAAEVRAARGWQVTVGAQGVREYYGGLSGLLMVGVTPPMFDAGQRERGALLAAAERLEGEAQEAALRAAAELALAFREREQTAAQLSVVEKSLAPKAEEAARLADVLLRAGQSTLPDVLRARRARAAANIRLALARGEASLAAARLHLLLSALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6T5</accession>
    <name>Q1D6T5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553474.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3441"/>
    <dbReference type="EnsemblBacteria" id="ABF92057">
        <property type="protein sequence ID" value="ABF92057"/>
        <property type="gene ID" value="MXAN_3441"/>
    </dbReference>
    <dbReference type="GeneID" id="41360789"/>
    <dbReference type="KEGG" id="mxa:MXAN_3441"/>
    <dbReference type="eggNOG" id="ENOG5032YB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113282_2_0_7"/>
    <dbReference type="OMA" id="WLIVENR"/>
    <dbReference type="OrthoDB" id="1557777at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025411">
        <property type="entry name" value="DUF4136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13590">
        <property type="entry name" value="DUF4136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188220" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4136" evidence="2">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="22996" checksum="96417FD79B710D02" modified="2006-07-11" version="1">MRLLFRITPVLLGLALAACSGIRVNTNYDPTAVERIDDFRRYAWLPQPQGKDARVYNDIIDVRVRMAVDQELKARGYQRVDMSEDPDFLVGWQGAINTKVSVDTVDSFYGYPWGPYWSPWSSFYGPYGYPYGMGGPRTYVREYDVGTLILDGVDAREQRLVWRGTAQAELHRNLSPDALQKKINDAVHKMLSRFPPRPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z1</accession>
    <name>Q1D6Z1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">MXAN_3385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553418.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3385"/>
    <dbReference type="EnsemblBacteria" id="ABF92656">
        <property type="protein sequence ID" value="ABF92656"/>
        <property type="gene ID" value="MXAN_3385"/>
    </dbReference>
    <dbReference type="GeneID" id="41360732"/>
    <dbReference type="KEGG" id="mxa:MXAN_3385"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_7"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
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        <property type="entry name" value="cyt_tran_rel"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="18019" checksum="104E2E40B46E3282" modified="2006-07-11" version="1">MLVAIYPGSFDPLTNGHLSLIQRSLKMFDRLIVAIAVNPKKTPLFSEEERLTLIREAVQDDRVEVDAFHGLLVDYVRRRNAGVIVRGLRAVSDFEYEFQLANMNRKLAPDVETVFMMTGEDYFYISSNLVREVASFGGDVTGLVPPNVHEGLKAKFAGRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D747</accession>
    <name>RL17_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">MXAN_3327</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="SMR" id="Q1D747"/>
    <dbReference type="STRING" id="246197.MXAN_3327"/>
    <dbReference type="EnsemblBacteria" id="ABF91562">
        <property type="protein sequence ID" value="ABF91562"/>
        <property type="gene ID" value="MXAN_3327"/>
    </dbReference>
    <dbReference type="GeneID" id="41360680"/>
    <dbReference type="KEGG" id="mxa:MXAN_3327"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_0_7"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000068023" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <sequence length="139" mass="15584" checksum="D3169468D1B6AFE9" modified="2006-07-11" version="1">MRHKVGQRKLHRSTSHRLAMLNNMVTSLLEHQAIRTTLPKAKEARKIAERIITLGKRGGLANVRLAARTVKDRDVLQKVFGEYKDRYASRPGGYTRIVRLGFRRGDAAEMALLELVDRPEKAAPVDTEAAAPAEETKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7B6</accession>
    <name>Q1D7B6_MYXXD</name>
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        <submittedName>
            <fullName evidence="6">Heme ABC exporter, ATP-binding protein CcmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccmA</name>
        <name evidence="6" type="ORF">MXAN_3258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF89321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3258"/>
    <dbReference type="EnsemblBacteria" id="ABF89321">
        <property type="protein sequence ID" value="ABF89321"/>
        <property type="gene ID" value="MXAN_3258"/>
    </dbReference>
    <dbReference type="GeneID" id="41360610"/>
    <dbReference type="KEGG" id="mxa:MXAN_3258"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="NLAWLCA"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005895">
        <property type="entry name" value="ABC_transptr_haem_export_CcmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01189">
        <property type="entry name" value="ccmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23443" checksum="0587009CFF9E50BC" modified="2006-07-11" version="1">MPPLSAAPALALHDVSKRYGRRWALARLTYALPAGRSLLLTGHNGSGKTTLLRLLATALSPTAGRVEVLGRDAVVERDAVRRDVALLSHASFLYEDLTAHQNLTVLARLLGLPSPADAASDELTRVGLSRRSDSPVRSFSAGMRKRLAIARLLLKAPSIALLDEPFGELDPAGIRDMEAIIAELKASGVTVILATHLIEQGLTLCEERLHLQEGRAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G4</accession>
    <name>Q1D8G4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552909.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2848"/>
    <dbReference type="EnsemblBacteria" id="ABF88945">
        <property type="protein sequence ID" value="ABF88945"/>
        <property type="gene ID" value="MXAN_2848"/>
    </dbReference>
    <dbReference type="GeneID" id="41360219"/>
    <dbReference type="KEGG" id="mxa:MXAN_2848"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102149_0_0_7"/>
    <dbReference type="OMA" id="WVARVPP"/>
    <dbReference type="OrthoDB" id="1646399at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="25208" checksum="8B1E58A8F93C62D8" modified="2006-07-11" version="1">MAQPGRRRMYLGMAGTAVMLLGGCASHRSSAKVDKQWVARVPPGELGNVREAQLTEDHAREQIPRTQVARQDAEAEREVAQRNEDATKSRHEAAEAALEAAQATGDVAAIERAQNAACTTQHALTLAEAETAWRDDAVTTLKSLEVMRQRELDVADAQLEQAKYEAVNANADVRAKELSPGDFSSAVADARRKAADQQRQVDANLQREHQAKARWQQLQDQGYGGSGSQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8L1</accession>
    <name>Q1D8L1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Nogalamycin resistance protein SnorO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">snorO</name>
        <name evidence="16" type="ORF">MXAN_2795</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552862.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2795"/>
    <dbReference type="EnsemblBacteria" id="ABF88899">
        <property type="protein sequence ID" value="ABF88899"/>
        <property type="gene ID" value="MXAN_2795"/>
    </dbReference>
    <dbReference type="GeneID" id="41360171"/>
    <dbReference type="KEGG" id="mxa:MXAN_2795"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_7"/>
    <dbReference type="OMA" id="VCFEGTV"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="443"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="481"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="749" mass="80832" checksum="1D877E014FD521B0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8T4</accession>
    <name>Q1D8T4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552789.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88460">
        <property type="protein sequence ID" value="ABF88460"/>
        <property type="gene ID" value="MXAN_2722"/>
    </dbReference>
    <dbReference type="GeneID" id="41360100"/>
    <dbReference type="KEGG" id="mxa:MXAN_2722"/>
    <dbReference type="HOGENOM" id="CLU_979018_0_0_7"/>
    <dbReference type="OMA" id="ADHVMVG"/>
    <dbReference type="OrthoDB" id="900641at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="32031" checksum="0AA9B060C750661E" modified="2006-07-11" version="1">MVRRIPRDGPARGRRCGGACYARVPMKRTLVSAALAASSLAFLACDLDQLTADHVMVGTLLSTPEVEVSASALAGYDAGTFSPDGGDVLALPAQTAAIVFFGSKTGENSQPSGLAGADITVQPVGGEATALADEGSGNYRRTSVGASNFTYQPGATYQFIANRGGTRYVGQVDDAPMKETIAALHPPEGFLRIDASTPLSFDRPAPPANTDRTLGFVTVVPLSAEGAQGEPTYTNLPSTPVQFLQLVGLPGPYREARVTIPGTAFPQREQTYLVIFHAVRMGGAESGNLFLGSALLAGTAEVGVVRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8X1</accession>
    <name>Q1D8X1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheW</name>
        <name evidence="3" type="ORF">MXAN_2685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2685"/>
    <dbReference type="EnsemblBacteria" id="ABF89623">
        <property type="protein sequence ID" value="ABF89623"/>
        <property type="gene ID" value="MXAN_2685"/>
    </dbReference>
    <dbReference type="GeneID" id="41360063"/>
    <dbReference type="KEGG" id="mxa:MXAN_2685"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_4_0_7"/>
    <dbReference type="OMA" id="SNGSMEF"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="57"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21012" checksum="4B6A3CAE5D5860D0" modified="2006-07-11" version="1">MSKDDAKIDYTGLRRQLTEAHSLLDGKQGVSPEKRREVLSARARALAESRHEERQEVLSVLAFQVGGERYAVRIEHVDHVIEARGIASLPGAPRHVLGALVSRSRVVPVLDLRQLLGLEGGGMSDLSKVVVVEADDSEEGFGLAAESVEGRKELPKAELSQPPPGPFLFLTPDRLTVLDLEQLGGPSATRPEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y3</accession>
    <name>Q1D8Y3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552741.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2671"/>
    <dbReference type="EnsemblBacteria" id="ABF91113">
        <property type="protein sequence ID" value="ABF91113"/>
        <property type="gene ID" value="MXAN_2671"/>
    </dbReference>
    <dbReference type="GeneID" id="41360049"/>
    <dbReference type="KEGG" id="mxa:MXAN_2671"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862531_0_0_7"/>
    <dbReference type="OMA" id="ITLRMDL"/>
    <dbReference type="OrthoDB" id="1259219at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="35186" checksum="A8F06D95CF557EB7" modified="2006-07-11" version="1">MRISAAMEFPFETGEGEGGEGGTLASTVLVVDDEPVVLDICARLLERDADLVVTLAASAEDALPLLAEQRFDVLVTDKNLPGMGGVELIAEARRLQPSLEAVMITGYASSESVVAAFAAGASDYILKPFDDLRVLRAKVRAALERRTAGLLVREQAREVAREAAALLASGQDAPERAYEALEAELRAYEEAVRLGLNGRVAVVGSASTVTVLQDAGFEAVELPPYAPELERVDVVIVETGDPQWRTLAERLQRRPPDVLLLASPQADLGDLLEAITLRMDLVGFGTSQGAVALPEKVRMLLLRRGVQRAQDRLAAALAAFRQSIAAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D923</accession>
    <name>Q1D923_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M28 (Aminopeptidase S) family</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552701.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2631"/>
    <dbReference type="EnsemblBacteria" id="ABF88269">
        <property type="protein sequence ID" value="ABF88269"/>
        <property type="gene ID" value="MXAN_2631"/>
    </dbReference>
    <dbReference type="GeneID" id="41360007"/>
    <dbReference type="KEGG" id="mxa:MXAN_2631"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019932_2_1_7"/>
    <dbReference type="OMA" id="VANINMD"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188374" evidence="2">
        <location>
            <begin position="35"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="314"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="575" mass="62766" checksum="5CC562402772DAC8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E9</accession>
    <name>Q1D9E9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative general secretory pathway protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_2505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP K family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552576.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2505"/>
    <dbReference type="EnsemblBacteria" id="ABF88661">
        <property type="protein sequence ID" value="ABF88661"/>
        <property type="gene ID" value="MXAN_2505"/>
    </dbReference>
    <dbReference type="GeneID" id="41359883"/>
    <dbReference type="KEGG" id="mxa:MXAN_2505"/>
    <dbReference type="eggNOG" id="COG3156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592699_0_0_7"/>
    <dbReference type="OMA" id="FAYNSRV"/>
    <dbReference type="OrthoDB" id="371149at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="50630" checksum="E3E1667E24ACADA5" modified="2006-07-11" version="1">MPLPFFQQTPRRRRKPPPRPARRERRSRGVALIIAIVSIALLTVIATDFAYNSRVDLQLAANQRDEVRAYYMARSGIALSRLLLRFQKQVDQTPIPNPAAILGQLGIGGTPQAGQVQPSSLNIQLFKMARVDCHMLRGLVKSDGAGGEVSALEPKQDDNFKLDEEDADPAAREVASQMTMRSFGGFEGCFLATISDEEEKLNVHRLIAGAGDARPTALRLMDMMADPRFEFLWERDDANKVRSTPQDVLLALKDWADDDRTGSAFNPVDPVNPLPGGFSDEGAAYSRYEPGYQPKNARFDSVDELYRVHGVNDQFMAAFRDRLTVYPDINRRPNINTDDPVMMGLAIMSVADQTRPDPRLRDPVFLNELIERVRAARMFSFFGMSVQDFVAVVEAAGILVDPAVKSNVAGNRLVGDKSQTFTIKSVGEAGSVQKTLTAVIRLDDTLGRLLYWREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9J9</accession>
    <name>Q1D9J9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552528.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2454"/>
    <dbReference type="EnsemblBacteria" id="ABF88027">
        <property type="protein sequence ID" value="ABF88027"/>
        <property type="gene ID" value="MXAN_2454"/>
    </dbReference>
    <dbReference type="GeneID" id="41359838"/>
    <dbReference type="KEGG" id="mxa:MXAN_2454"/>
    <dbReference type="HOGENOM" id="CLU_119500_0_0_7"/>
    <dbReference type="OMA" id="FKAWMKN"/>
    <dbReference type="OrthoDB" id="1567587at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="20323" checksum="15E2E5A142065471" modified="2006-07-11" version="1">MSNPNPDPRVPAQMPPEAPPELVAKRERLVTELENQAKSATGTLQQVMRKMSALLGNTKPGASLSFQLYQDVKDAFTRHLNEATKTPALATMPPVLVESVEWMQAYLNARGFSTDEAAASAPAATAAPAAAAKAPVGPGGAKDAFETSSKKHASLTGDVPPPPAAPPDVKAEQKDLESFKAWMKNPSLGKLKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W9</accession>
    <name>CYSI_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfite reductase [NADPH] hemoprotein beta-component</fullName>
            <shortName evidence="1">SiR-HP</shortName>
            <shortName evidence="1">SiRHP</shortName>
            <ecNumber evidence="1">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysI</name>
        <name type="ordered locus">MXAN_2334</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
        <text evidence="1">Binds 1 siroheme per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552409.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D9W9"/>
    <dbReference type="SMR" id="Q1D9W9"/>
    <dbReference type="STRING" id="246197.MXAN_2334"/>
    <dbReference type="EnsemblBacteria" id="ABF92185">
        <property type="protein sequence ID" value="ABF92185"/>
        <property type="gene ID" value="MXAN_2334"/>
    </dbReference>
    <dbReference type="GeneID" id="41359720"/>
    <dbReference type="KEGG" id="mxa:MXAN_2334"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_3_2_7"/>
    <dbReference type="OMA" id="MGMTHGD"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000388501" description="Sulfite reductase [NADPH] hemoprotein beta-component">
        <location>
            <begin position="1"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01540"/>
        </source>
    </evidence>
    <sequence length="562" mass="62086" checksum="65D27288DDF71F1C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y0</accession>
    <name>Q1D9Y0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein, OMP85 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552398.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2323"/>
    <dbReference type="EnsemblBacteria" id="ABF92833">
        <property type="protein sequence ID" value="ABF92833"/>
        <property type="gene ID" value="MXAN_2323"/>
    </dbReference>
    <dbReference type="GeneID" id="41359710"/>
    <dbReference type="KEGG" id="mxa:MXAN_2323"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579663_0_0_7"/>
    <dbReference type="OMA" id="FTAEYHF"/>
    <dbReference type="OrthoDB" id="344011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="4">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="487" mass="53494" checksum="35D4B0729FA40FDE" modified="2006-07-11" version="1">MARGAPPGTKLEVDCAWRARPAAPFTDVQRVMSRRVWVRCAALGLSLLASQAPAQITESDPVVEEVVVRGPEKTQPDTVRAYARVGEGDPLTLEDLAKVERRLVATGLFQEVKVSYEPSGPGRVRLILEVEDKASWVVAPTFVLQSDNVGGGVLYAENNLWGRSKKFATAAQVSTAESGIFAGFLDPNLFGLPQLRFSLEGQLRSDRVDEYQAGSGQRRPEVVRRTRMNSASIAGELGFLLFERVRAAAKYRLMSIDAKSPDTAEEVTTPAFSLGPSQQDASLRLMVGIDTRQNLHAVMEGLNLEASYELSNPGVGSDFRYERFGLLYRHGLRLVGEHNLVLRGEAVAGVDLPFHQEFVMGGNSLRGFVYRQFRGDTRLSFTAEYHFPLFTVNPLSFRGVAFSDTGMMMWRKLPGDRELRDVNGRVVRSYLPDTEDGLGNATVAQGVGAGLRLYLRNIVLPLVGVDAAYSVNSGEFRFYLVAGVNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA67</accession>
    <name>Q1DA67_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552311.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2235"/>
    <dbReference type="EnsemblBacteria" id="ABF89747">
        <property type="protein sequence ID" value="ABF89747"/>
        <property type="gene ID" value="MXAN_2235"/>
    </dbReference>
    <dbReference type="GeneID" id="41359623"/>
    <dbReference type="KEGG" id="mxa:MXAN_2235"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054750_7_1_7"/>
    <dbReference type="OMA" id="RRCFFVG"/>
    <dbReference type="OrthoDB" id="1274094at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="25756" checksum="97FD5756D7DE5860" modified="2006-07-11" version="1">MPSSDSLLVTVAVFVLAGLVKGVVGLGLPTIAMALLALVMPPARAAVLLIVPSLVTNVWQLRPWSTLGPLLRRLARMQVGVCAGTLVGAWVLGAPVGAWATVSLGVALVAYAAWGLSGARLPVGPVAEARLGPWVGALTGFVTAATGVFVIPAVPYLQALGFEREELIQAMGISFTVSTLALAAGLYVNAAGAGAQLGQSLLMLLPALVGMQVGQWLRQKLSPVLFRACFLVSLMLLGMHMVAREMRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAA4</accession>
    <name>Q1DAA4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91228">
        <property type="protein sequence ID" value="ABF91228"/>
        <property type="gene ID" value="MXAN_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2196"/>
    <dbReference type="HOGENOM" id="CLU_3155202_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="48" mass="5349" checksum="C52A485D1E136236" modified="2006-07-11" version="1">MISDTVIFPACRRSHRPGTSPMGLAVTSWNPFSVQENEKEALEARLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAC3</accession>
    <name>Q1DAC3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552255.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2177"/>
    <dbReference type="EnsemblBacteria" id="ABF91050">
        <property type="protein sequence ID" value="ABF91050"/>
        <property type="gene ID" value="MXAN_2177"/>
    </dbReference>
    <dbReference type="GeneID" id="41359570"/>
    <dbReference type="KEGG" id="mxa:MXAN_2177"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_147_1_7"/>
    <dbReference type="OMA" id="RRINEHR"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="43535" checksum="7D92765BAA69CD4C" modified="2006-07-11" version="1">MRAFPQPDAAGSVFLVALVASSHTRGNGMSKAIEFKIPRGAILFSAGGVGYEYREDLGPTHHGMALFVARLRTASGAPRGKVLLKAVPAPSETEGARVMRARAKLDEQVRLATFLNHPSILKVHGLHKVEGYWYVSTEHPDGHSLNELLTLVGESQRWFPPLFVLYVGAQVAAALEHAHAAKDEQGRPLNIVHRAVDVEHVFVNWDGTVQLADFGLALSDLPGRVASSARGPYGDHFYSSPEMLLGGSVDARSDLFMLGVVLLELATGKNLLFCPDDITPEVMGSLPTKKRRRVARAIKRATLAGAPPLVADAIWRAATLTAADVDAMTEGLPQGLRVTLNRLLRVAPRERYQSAGESHGLVAHEEASSGRSGNQAGHARRGAAVGGRRDLARGDTDGCGRRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR0</accession>
    <name>Q1DAR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552118.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2034"/>
    <dbReference type="EnsemblBacteria" id="ABF91666">
        <property type="protein sequence ID" value="ABF91666"/>
        <property type="gene ID" value="MXAN_2034"/>
    </dbReference>
    <dbReference type="GeneID" id="41359444"/>
    <dbReference type="KEGG" id="mxa:MXAN_2034"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_4_7"/>
    <dbReference type="OMA" id="SIAKFPM"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="26636" checksum="CB54B26A62D7B2BF" modified="2006-07-11" version="1">MSVRVEKNGLVTTVILDRPEVRNAVDGATAQALAEAFRAFDADPDARVGVLHGEGGTFCAGADLKAVSEGRMPRLELDGDGPMGPSRMVLSKPVIASIGGHAVAGGLELALWCDLRVAEEDAVLGVFCRRWGVPLIDGGTVRLPRLIGLSRALDLILTGRPVSAQEALAMGLVNRVVPRGQAREAAEALAREVAAFPQACMNADRRSAYTQAGLGTEEALRQEFARGVKVLESESIAGATRFAQGAGRHGKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAV3</accession>
    <name>Q1DAV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1985"/>
    <dbReference type="EnsemblBacteria" id="ABF90913">
        <property type="protein sequence ID" value="ABF90913"/>
        <property type="gene ID" value="MXAN_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1985"/>
    <dbReference type="eggNOG" id="COG2404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868271_0_0_7"/>
    <dbReference type="OMA" id="CERYGGG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="38246" checksum="DB8386EAF60AB9EE" modified="2006-07-11" version="1">MAARTRRPSRRWARDSHCSKGLIAMNVQVLFHDSCFDGAASAAVFSRFYRERIRPDAAFRYLGLNHKPGAEGIDPAVFSGEENVIVDFRYSQDARLTWWFDHHASAFQQPGDEAHFRADTSGRKFHDAHRKSCTKYLADVARERFGWDASPLAELIHWAEIIDGAQFPSPQMAVALEEPALRIMTVLEANKDPSLIPEVIRRMQSESLADIATSPLIAAPLAPLLARHQSNIELVRARARYERGVVFFDLVDEGVDSLNKFIAYALYPDARYTLWVGKGASRAKVSIGSNPWKPELRRHDLSAIAGRYGGGGHPVVAAVSFKADQADKARAAYAEILAELSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB61</accession>
    <name>Q1DB61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage head morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551968.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1866"/>
    <dbReference type="EnsemblBacteria" id="ABF86414">
        <property type="protein sequence ID" value="ABF86414"/>
        <property type="gene ID" value="MXAN_1866"/>
    </dbReference>
    <dbReference type="GeneID" id="41359282"/>
    <dbReference type="KEGG" id="mxa:MXAN_1866"/>
    <dbReference type="eggNOG" id="ENOG5033J06">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040915_0_0_7"/>
    <dbReference type="OMA" id="DVDWRTT"/>
    <dbReference type="OrthoDB" id="645619at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="359" mass="39259" checksum="8CFEF2CEBB36B64B" modified="2006-07-11" version="1">MCTAPADSLLLMHEARAVADALLGDVLRLPVAKALDVGTAAGMDRAVALLAARLRRAVGRADVDAMREAVAVLDVDWRTTTAAQRRRLVAQALEAAGRQTAVIPARIQAPLGDAAEEVVASTRSHARREQGLALAARFNAVDRRVAQHIVRTQGNFVRDEYGRRLDAFGEEVRRLVAEGLEAGLGRSDIAESLERAARGALIERAPFYWEVVASHFIGQGRSFAQVSSYAEAGIRRYRIEAVLDEATTQVCRFLHGRTFAVADALQRFERVESLERPEDVKQELPWVRERLDADTGRALLYVNRGGQETRLAEVLRSAASTRDDVGEFRALASDRQLADAGVGFPPFHGLCRTTTLAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB95</accession>
    <name>Q1DB95_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92832">
        <property type="protein sequence ID" value="ABF92832"/>
        <property type="gene ID" value="MXAN_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1832"/>
    <dbReference type="eggNOG" id="ENOG503295H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2383129_0_0_7"/>
    <dbReference type="OMA" id="MYVFARS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="11993" checksum="F0D099FA070A2068" modified="2006-07-11" version="1">MYVFARSPLRAKETPMVIGTDTTYLGNEIPGLRGQKVRIFAVLRGGLRPDANPDADDYYVNDNETLAHLGGVTAEDCIDAALILPDGTTSFVHFDPRAIDLECFAHLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBC3</accession>
    <name>Q1DBC3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87040">
        <property type="protein sequence ID" value="ABF87040"/>
        <property type="gene ID" value="MXAN_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1804"/>
    <dbReference type="HOGENOM" id="CLU_3027538_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="55" mass="6075" checksum="24CB3B9AD9DEADF8" modified="2006-07-11" version="1">MLNHLRAETESRYLLDDQARAASSIGVLGEAFRAARASKVEMPADPLLHIDLAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG8</accession>
    <name>Q1DBG8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1755"/>
    <dbReference type="EnsemblBacteria" id="ABF91166">
        <property type="protein sequence ID" value="ABF91166"/>
        <property type="gene ID" value="MXAN_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1755"/>
    <dbReference type="HOGENOM" id="CLU_2789594_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="68" mass="7292" checksum="E8CFA1A9F08FF455" modified="2006-07-11" version="1">MGTAGHSSTPGGMRAHLNDNGKRSASRRIRGAQDMIDFCELNNIKPGIESPMTGINEAWPKAVGKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBP7</accession>
    <name>Q1DBP7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551785.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1674"/>
    <dbReference type="EnsemblBacteria" id="ABF89483">
        <property type="protein sequence ID" value="ABF89483"/>
        <property type="gene ID" value="MXAN_1674"/>
    </dbReference>
    <dbReference type="GeneID" id="41359113"/>
    <dbReference type="KEGG" id="mxa:MXAN_1674"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_7"/>
    <dbReference type="OMA" id="AGMVHHS"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="35666" checksum="B73AFE52126E4FB7" modified="2006-07-11" version="1">MRLARGAAVKTLVTGASGFLGRNLLETLGDDAVALVRSPLPGPVAQVSGTPLDPDAWLSQAQGVKVLIHSAGMVHHSRQHADEMVRFNIDSSLAMVRAAKALDARLVLVSTSGTVGCFSHPTIEADEHSLYAEALVGRWPYYLSKILAEQQSRKLAKQLGVEMTVVRPPVLLGPGDTLGRSTTNVARVLNGRLPFIPTGGIAFTDVRDVAHALAVLAKKSDWRDTYHLSGTTLPLRTFFERVGEVAGIRVNRPGVPTLVVDGLAKLGAHVPLKKLPDPVVLEMSTCHWGFKTLWSHEELDYRPRSHRQTLSDTVAWLREAQARQTPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC13</accession>
    <name>Q1DC13_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1558"/>
    <dbReference type="EnsemblBacteria" id="ABF90594">
        <property type="protein sequence ID" value="ABF90594"/>
        <property type="gene ID" value="MXAN_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1558"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_4_7"/>
    <dbReference type="OMA" id="HKAFGIH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="465" mass="48338" checksum="DDC8AA0B6FBCA7B4" modified="2006-07-11" version="1">MKRGESAPSPSLRVLDVMALTVGIVLGAGIFKAPSLVAAQSGSGEAMLLTWLLGGVASLVGALCYAELASAWPHPGGDYHYLYRALGKGPAFLFAWARLTVIPTGSIALLAFVFGDYATQLFPLGLYSSPVYAAMLVVGLTAVNIAGLRQGTRTQNLLTALEVLGVGAVVIVGLLFTPALVPAAAPPAPAASSGTAWGLAMVFVLLTYGGWNEVAYLSSEVRGSRRTIAWSLLASIGLVTALYLLVNVAYLRGLGLEGMARSEAVAADLMQRAVGSGGALVLSVIIAISALTSANATVLTGARTHYAFGRDSVLFNGLGQWHAKSNGPSRALLVQGAISLALVGLGTLTRQGFETMVEYTAPVFWLFFLLTGVSLMVLRVREPDAPRPFRVPLYPLTPLLFIGICAYVLYSSLAFTGLGALAGLAVLGTGGVLLAVEAVRTRRGSQGTSPKASSSPRLQRTKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCF4</accession>
    <name>Q1DCF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551529.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1412"/>
    <dbReference type="EnsemblBacteria" id="ABF91843">
        <property type="protein sequence ID" value="ABF91843"/>
        <property type="gene ID" value="MXAN_1412"/>
    </dbReference>
    <dbReference type="GeneID" id="41358858"/>
    <dbReference type="KEGG" id="mxa:MXAN_1412"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_3_2_7"/>
    <dbReference type="OMA" id="NNEDFHR"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="26485" checksum="9BF0B94DB3054CA4" modified="2006-07-11" version="1">MRMDSAGQTHIGRRPHNEDAFCVAPELGLFVVADGLGGQEGGEVASRCVVDTFVGFGLRLGQDRDSTWPTVPDPRRSREENLLAACSALAQRNLQAQRVGRLREMASTVVALAVSEHGAAVAHVGDSRLYRLRGGKLESLTRDHSLIEELRDAGMEPPGGSGNLRHLITRALGTENAEPTVQRLQTEPGDVFLLCSDGLYEPLGVEGLMKRLTMSSAREVCDALVADAYEAGGKDNITAVVLRVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCG3</accession>
    <name>Q1DCG3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551520.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1403"/>
    <dbReference type="EnsemblBacteria" id="ABF86441">
        <property type="protein sequence ID" value="ABF86441"/>
        <property type="gene ID" value="MXAN_1403"/>
    </dbReference>
    <dbReference type="GeneID" id="41358850"/>
    <dbReference type="KEGG" id="mxa:MXAN_1403"/>
    <dbReference type="HOGENOM" id="CLU_2274318_0_0_7"/>
    <dbReference type="OMA" id="GPECELI"/>
    <dbReference type="OrthoDB" id="2210994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="10197" checksum="3C454D96EE36F605" modified="2006-07-11" version="1">MPSSPEPSSPQRPSLGRSAATGLLGGFLLGGLGLLAVGLSNSFAAPSCDGLTGPECQLLTDATREVGRTQLLAGGALTALAASLFVLFRPRPPAPPEGPEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI8</accession>
    <name>Q1DCI8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551495.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1378"/>
    <dbReference type="EnsemblBacteria" id="ABF86543">
        <property type="protein sequence ID" value="ABF86543"/>
        <property type="gene ID" value="MXAN_1378"/>
    </dbReference>
    <dbReference type="GeneID" id="41358824"/>
    <dbReference type="KEGG" id="mxa:MXAN_1378"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="HVTPHEI"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13601" checksum="B4697DEABA1012A9" modified="2006-07-11" version="1">MSHILVVDDDASHRTLICDALEEMGYPTVQAANGREALDLLEGDMPSAVLLDLRMPVMSGWGLLDALKKMPRARGLPIIIISGYGFEWEAELVGAAGYISKPVDLDKVRMTVQQIAGPPEMSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDC2</accession>
    <name>Q1DDC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551211.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1091"/>
    <dbReference type="EnsemblBacteria" id="ABF90742">
        <property type="protein sequence ID" value="ABF90742"/>
        <property type="gene ID" value="MXAN_1091"/>
    </dbReference>
    <dbReference type="GeneID" id="41358542"/>
    <dbReference type="KEGG" id="mxa:MXAN_1091"/>
    <dbReference type="HOGENOM" id="CLU_189936_1_0_7"/>
    <dbReference type="OMA" id="ETYIEDC"/>
    <dbReference type="OrthoDB" id="1956325at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025990">
        <property type="entry name" value="Cys_rich_CPXCG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017143">
        <property type="entry name" value="UCP037225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14255">
        <property type="entry name" value="Cys_rich_CPXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037225">
        <property type="entry name" value="UCP037225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="64" mass="7065" checksum="CD1545B82471827B" modified="2006-07-11" version="1">MQPFAESAAQLCPYCGEEVEVAVDPIGVASETYIEDCPVCCRPWTVQVSRDEESFAVHLGRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDD4</accession>
    <name>Q1DDD4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551199.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1079"/>
    <dbReference type="EnsemblBacteria" id="ABF90334">
        <property type="protein sequence ID" value="ABF90334"/>
        <property type="gene ID" value="MXAN_1079"/>
    </dbReference>
    <dbReference type="GeneID" id="41358530"/>
    <dbReference type="KEGG" id="mxa:MXAN_1079"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000493_0_0_7"/>
    <dbReference type="OMA" id="CEPLTEM"/>
    <dbReference type="OrthoDB" id="1217175at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="29855" checksum="6BD34A6D804902CF" modified="2006-07-11" version="1">MGSSESQWVLRPGRLEDHAVFARLFLELGVDEPSPPEPVWAAEIAQRSLFAEGPQGVGAYAVTNVLGDFGFVRQLVVAPFARGQGLGRRMMTHLAGHFRAQGCTRWVLNVKRDNRPALELYTSLGMRPAREATTLRVTRAHLAALPPASPDGAVVPVSLEDCGALTEAFGMIPGKLAASAASDSHRLLGLIDPQAPARRWLGMMDLRPGPSLFPFFAVSPGHARTLLEEAFGQLEEGASSLNVTVAEDAPLVHLFRDAGAQTRLETLELRGLLVDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH1</accession>
    <name>Q1DDH1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551162.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1041"/>
    <dbReference type="EnsemblBacteria" id="ABF92894">
        <property type="protein sequence ID" value="ABF92894"/>
        <property type="gene ID" value="MXAN_1041"/>
    </dbReference>
    <dbReference type="GeneID" id="41358495"/>
    <dbReference type="KEGG" id="mxa:MXAN_1041"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_0_1_7"/>
    <dbReference type="OMA" id="YGDFSYG"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="376" mass="41098" checksum="1F9BA31237066AB0" modified="2006-07-11" version="1">MAPFPIPMSLHSAPTLQASLDSRRNNLDFLRFAAATCVLLSHAFPLGEGKGTVEPLESFTRGQFSLGRLGVAVFLIISGVLITRSWERTPDAARFIWARVLRIFPGLGAMLLLTVGVLGPAFTRLSLGDYFTAPDTALYLLGNFALNWPQWHLPGVFEANAYPHAVNGSLWTLKYEVGFYLLTLGLGLTGLLRKGMVIFGLVGAAVATFVTGRLGFWPELYLYFGGGVALYQWREHVRMSPWVAAACVVGWLITARLGYGCRIATGLLGGYVVLYLAFRPMGALADFGRRGDLSYGVYLYAFPVQQAVTTLLGGPTAWWVNAAVAFPCVLLLAALSWRWVEQPALRRKDRLPAWVRRPAVSVTAVPKTPSRPAGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX1</accession>
    <name>Q1DDX1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551012.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0891"/>
    <dbReference type="ESTHER" id="myxxd-q1ddx1">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88087">
        <property type="protein sequence ID" value="ABF88087"/>
        <property type="gene ID" value="MXAN_0891"/>
    </dbReference>
    <dbReference type="GeneID" id="41358350"/>
    <dbReference type="KEGG" id="mxa:MXAN_0891"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024314_1_0_7"/>
    <dbReference type="OMA" id="DFQDWRG"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="40212" checksum="B8BF79483FA72762" modified="2006-07-11" version="1">MDAKTLEARARAEGTPVIESDTATFVWRGRGPICLQGDFQDWRGKPLPFKRVAPGLWARTLTLPADAYVEYALEDPRGQRVEDPLNRHPSDNGFGGINHSFHMPQARSSLPARHPRGAPRGRVTRHVVDTGDVDLPGQRRVYLYAPPTDASVPLVVVYDGEDYLRRVRLPELVDTLVAEGRMRPVALALVCNGGETRSMEYACSEYTVGLLKWKVLPLARQKLSLVDERRSPGAHAVLGASLGGLMALYTGLRMPDVFGRVLSQSGAFAVEGHDFVVFDLARPPPRRPLDIWLDCGRFEGLLEGNRRIAPVLSEAGHQVELREYSGGHNYPAWREDLVHGLERHFPPPPAKRRESLRFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX4</accession>
    <name>Q1DDX4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551009.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0888"/>
    <dbReference type="EnsemblBacteria" id="ABF85879">
        <property type="protein sequence ID" value="ABF85879"/>
        <property type="gene ID" value="MXAN_0888"/>
    </dbReference>
    <dbReference type="GeneID" id="41358347"/>
    <dbReference type="KEGG" id="mxa:MXAN_0888"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_5_0_7"/>
    <dbReference type="OMA" id="AWPGFLW"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="241"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="465" mass="49395" checksum="46332D19FE3E67CE" modified="2006-07-11" version="1">MDTARFILFALVTGIATVAVHVYLYRRLFTATSEHRAWRRVGMGVMTVLGTLLVLSWSVTRFLPMDSTFAVATAVWTWMGMAIYLLLALGVLGAVRKVAARMQRSSGEPAVVELRGGETASVSHAHAVDGSAQAGGTLAATGTESVSVTPEALATSGHGAAATHAEAAPVAMAERPGGATSEAPAPVDVERRRFLARATAGGAVLAAGGVTGFGMWSAFHPPVVNEVAVKLPGLPKALDGFSIVHLSDIHVGPVIRRRFMDELVRRCNALRSDLVCITGDLVDGHVASLAPAVSALSELKSRHGTYFVTGNHEYYWSDAAWAEALERMDVHVLRNRHVRIGDTAASFDLVGVDDWSAGKMGFSQGYDLAAATAGRDSERASVLLAHQPSNWKVAAREGMGLQLSGHTHGGQFFPFTLAVSAIWEHDAGLFHEGDRHLYVSRGTGFWGPPLRVGAPPEIVRVTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX6</accession>
    <name>Q1DDX6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal dependent amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551007.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0886"/>
    <dbReference type="EnsemblBacteria" id="ABF93123">
        <property type="protein sequence ID" value="ABF93123"/>
        <property type="gene ID" value="MXAN_0886"/>
    </dbReference>
    <dbReference type="GeneID" id="41358345"/>
    <dbReference type="KEGG" id="mxa:MXAN_0886"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003995_0_0_7"/>
    <dbReference type="OMA" id="YGDTAMV"/>
    <dbReference type="OrthoDB" id="15167at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LTD" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF93123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1550" mass="159667" checksum="CBC3EFA6D972152C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY3</accession>
    <name>Q1DDY3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551000.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0879"/>
    <dbReference type="EnsemblBacteria" id="ABF89844">
        <property type="protein sequence ID" value="ABF89844"/>
        <property type="gene ID" value="MXAN_0879"/>
    </dbReference>
    <dbReference type="GeneID" id="41358338"/>
    <dbReference type="KEGG" id="mxa:MXAN_0879"/>
    <dbReference type="eggNOG" id="COG5622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105864_2_2_7"/>
    <dbReference type="OMA" id="KSEQATW"/>
    <dbReference type="OrthoDB" id="1859504at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019291">
        <property type="entry name" value="Host_attachment_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10116">
        <property type="entry name" value="Host_attach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="146" mass="16610" checksum="4CF040F67F31A0A8" modified="2006-07-11" version="1">MANGTLWILVGNASRARLFATDAKAEEDWRLVEEFHHDESRARQAELIEQADNPNAGTLHGPPAENEPNGRRELEHDRFARELSVFLDKAHDRRDFDKLVIAAPPGFLGRIRRLLSARVRQRVLLDVDSDYSNVPAKELPNRVPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDZ3</accession>
    <name>Q1DDZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0869"/>
    <dbReference type="EnsemblBacteria" id="ABF91064">
        <property type="protein sequence ID" value="ABF91064"/>
        <property type="gene ID" value="MXAN_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0869"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707350_0_0_7"/>
    <dbReference type="OMA" id="FRRPQFE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="42611" checksum="DDDFF6CD4D5D8849" modified="2006-07-11" version="1">MLEAMPGKHRVYLVPGFFGFINLGELIYFGHALDYLKDELARRQVEAEVIIVLSHPTASIRTRTADLLKAVQETASGDDGPIHLIGHSTGGLDSRLFVSPGAQVAEGVDLEPFARRVRTVTSVSTPHAGTPLATFFMGLFGQRILKLLSLFTVYVLRFGRLPLRVVFRFGHLLARADDQLGWKPTLLDQLYDQLLGDFSSERRDAVSKFLSDVGNDTSLIPQLTPEGIDLFNASTLDRPGVRYGSVVTQARPPSLRTRMAAGLDPYAQLTHTIYALMYGQTQRMPLTALPLHTPAQTAALVQAYGAMPGPTACDGIVPTRSQVYGRVLAAVRADHLDAIGHFDQPAHQPPHVDWLISGSGFRRPQFESTWKSIVDFMLEDERPGITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE69</accession>
    <name>Q1DE69_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0791"/>
    <dbReference type="EnsemblBacteria" id="ABF85872">
        <property type="protein sequence ID" value="ABF85872"/>
        <property type="gene ID" value="MXAN_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0791"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_1_7"/>
    <dbReference type="OMA" id="FFEHLLF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188440" evidence="2">
        <location>
            <begin position="38"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="87"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="225"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="53930" checksum="BCC4FF857E95BBBD" modified="2006-07-11" version="1">MRRRPFPGALPTGARMFRQSLLWTSCLALLAGPVACAQTQGGKPVAKSAVSAAPKLGAGIESRTLKNGLKVIVWPDHDIPNVVLYNWFRVGSRNEYPGITGLSHFFEHMMFNGAKKYGPGEFDRVMEANGGANNAFTSEDVTVYMDWFPRSALDVIFDLEADRLQHLAIDPKVTESERGVVYSERRSAIDNDNMGALMEQVQATAFVAHPYQFPVIGWPSDIESWRIEDLQRYYKTYYAPNNATLIFTGAVTPAEIFALAEKYLEPIPSQPAPEPVRTKEPEQQGERRIVVKKQAQAPLIQLAYHGISGKDADVEALTLLLSILTNGDSSRLHRRLVEEERAALRVNTHFSPGFDPSLVWVYADLPPGADVAKVEGLLTEELARVVKDGVSDAELKKARNITLSQFWRSLETNNGRGRALGAAETFRGDYRQLFDAPDRYERVTRDDVRKVAARIFNSQRRTVGWLVPADAQAATPDSRKEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEC5</accession>
    <name>Q1DEC5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550858.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0732"/>
    <dbReference type="EnsemblBacteria" id="ABF88721">
        <property type="protein sequence ID" value="ABF88721"/>
        <property type="gene ID" value="MXAN_0732"/>
    </dbReference>
    <dbReference type="GeneID" id="41358203"/>
    <dbReference type="KEGG" id="mxa:MXAN_0732"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="PHRDEGA"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="14838" checksum="EE640E2C9A2B92CB" modified="2006-07-11" version="1">MSEEKARVLVVDDDPDLLDLVQRSLSAYGFEVLTHTSALGVSNLVRSVEPDFVLIDVNFPALKGDKVVNLARQYALPKTKFILYSASDESKLRSLALASGADGYISKSVQGEELAQRLRAFHLKPRPPTPTPAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE3</accession>
    <name>Q1DEE3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_0712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550840.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0712"/>
    <dbReference type="EnsemblBacteria" id="ABF86070">
        <property type="protein sequence ID" value="ABF86070"/>
        <property type="gene ID" value="MXAN_0712"/>
    </dbReference>
    <dbReference type="GeneID" id="41358185"/>
    <dbReference type="KEGG" id="mxa:MXAN_0712"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_7"/>
    <dbReference type="OMA" id="KNTINVM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="32"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="398"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="490"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="582"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="674"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="766"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="858"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="950"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="1276"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1687"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1833"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1172"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1614"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1736"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF86070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1967" mass="212750" checksum="D8591A37B123950E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEY8</accession>
    <name>Q1DEY8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase, IS630 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550648.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0516"/>
    <dbReference type="EnsemblBacteria" id="ABF89498">
        <property type="protein sequence ID" value="ABF89498"/>
        <property type="gene ID" value="MXAN_0516"/>
    </dbReference>
    <dbReference type="GeneID" id="41364670"/>
    <dbReference type="KEGG" id="mxa:MXAN_0516"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_4_2_7"/>
    <dbReference type="OMA" id="WKEATWA"/>
    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_33" evidence="1">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="23074" checksum="167CCAA75F724589" modified="2006-07-11" version="1">MKGVVMGQQPFRLTLGQMEERRLFAASLLKSGWRPVDVADECGVTRGAVSQWCKALAQGGVRRLRRKPHQGRPSRLSSSEWKQVARAFKAGAVRAVFPTERWTLPRIARLIEQRWGVRYHPRSLSRPLHRLGFSAHRPRPQARERDDALIEAWGRRDWPRIKKGLEEAGGRLPSWMRRVTRFGPAWAPPGRRWGKSESSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ1</accession>
    <name>Q1DEZ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0514"/>
    <dbReference type="EnsemblBacteria" id="ABF88381">
        <property type="protein sequence ID" value="ABF88381"/>
        <property type="gene ID" value="MXAN_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0514"/>
    <dbReference type="HOGENOM" id="CLU_1426610_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="20790" checksum="B0491F3CC4A95E77" modified="2006-07-11" version="1">MHTHGPFVVSGDGPSSDVVAKKDLRGLRLDDAGGHGPQPELVPLAQVPPGQEQVRVPRAPEHHAPPATLHRLVVKEGIELLGERHGLQLGAEQEVKHGNLSGFDGPHDGARDDHRAQVREGLLREDGLDLAHGPFVDGAVERLGVPLLARDREAPEQDQRRERHDRQEPLLQRRHASVIASGPGLQEYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF03</accession>
    <name>Q1DF03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0500"/>
    <dbReference type="EnsemblBacteria" id="ABF88708">
        <property type="protein sequence ID" value="ABF88708"/>
        <property type="gene ID" value="MXAN_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0500"/>
    <dbReference type="HOGENOM" id="CLU_603862_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="48760" checksum="B7E7796078A2E69C" modified="2006-07-11" version="1">MDIGSSPMSTGGSYSPWSARPSVRLESKVRRGLRTAALLLLLAGGCRSPSLLTDGRTHETLPGQEASPARRVGGGPWLLQVRKQDLWVRTPAGDSEYALTRTGRVVATRPYGNGLGWSGVAISPDGRQVAYVERPEAQEHESPGRWALLWIVNSDGSGRRMLLDLREHALTPGPFRAGPILWSSDGARIAFSLESFARTGPESRPCPLAEVHTVEVGSGKVERLFESPTHGMLTPRGWSAQGTVSFSLLSCEATAEVGKDGRFFEFEPGRGIRDAHARGAVSSDGVHTLLLPSTPEAGVPTALLDGRKVDAPSEVDTRLLRHVAWMQHHPVAYLTTYSGQPRSCAFDRVPAPALFQANFDASRPGIEPRTGLGGLMVLAFSPDDAHVLAATVLLRSQASEVCWPDTFDSLLVMERVQLENSPTLTALSASSIRLDVPASQVGPELQGFVGWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF07</accession>
    <name>Q1DF07_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550629.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0496"/>
    <dbReference type="EnsemblBacteria" id="ABF89756">
        <property type="protein sequence ID" value="ABF89756"/>
        <property type="gene ID" value="MXAN_0496"/>
    </dbReference>
    <dbReference type="GeneID" id="41357983"/>
    <dbReference type="KEGG" id="mxa:MXAN_0496"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_1_7"/>
    <dbReference type="OMA" id="GYTIIYV"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="13989" checksum="08D5128DBE014DC9" modified="2006-07-11" version="1">MKLGYIILYVPDVSATIAFYEKAFGLARRFIHESGGYAEMETGTTALAFVEEGAAKEHGFTVRHLRPKEEAAAIELALVTADVAAAYTRAVEAGAEATQPPKQKPWGQTVAYVRDLNGVLVELCSPMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF40</accession>
    <name>Q1DF40_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepP</name>
        <name evidence="9" type="ORF">MXAN_0463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550596.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0463"/>
    <dbReference type="EnsemblBacteria" id="ABF86100">
        <property type="protein sequence ID" value="ABF86100"/>
        <property type="gene ID" value="MXAN_0463"/>
    </dbReference>
    <dbReference type="GeneID" id="41357956"/>
    <dbReference type="KEGG" id="mxa:MXAN_0463"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_2_7"/>
    <dbReference type="OMA" id="DQKFIYN"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="467" mass="50608" checksum="7E8A2262642DFA05" modified="2006-07-11" version="1">MLLPSVSERSALTRRREQLAKALGSAAALLASSRPRPRNYAADQFPFRASSHFLYLFGLATPDGVGLYDGQGWTLYLPEPGPDDALWDGAVPGFAEIAERTGCTVRSRAELPAALKGRDVAALPTPDLETCLDVAALLGREVRPGHLAAVDVPLADAMIALRLRHDDAAQAQLRQAAEVTVLAHMAGMRATRPGILEAAVRAAMEAEFVSRDVRPAYQPIVTVHGEVLHNLRYDHTLREGDLLLADVGGESPAGFACDVTRTWPVTGRFSTTQRELYDVVLRMQKASIDAVQPGTRYRDVHLAAHREMARGLVALGILRGDPEELVVDGVTALFFPHGVGHLLGLDVHDMEDLGDRAGYAPGRTRSPEFGHRSLRLDRDLEPGMAVTIEPGMYQVPAILSDARLMARAKDRLQRDVLARYADVRGIRIEDDVLVTSDGNEVLTAAIPKEASDIEAVMTSSARPAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF67</accession>
    <name>Q1DF67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550569.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0436"/>
    <dbReference type="EnsemblBacteria" id="ABF91540">
        <property type="protein sequence ID" value="ABF91540"/>
        <property type="gene ID" value="MXAN_0436"/>
    </dbReference>
    <dbReference type="GeneID" id="41357928"/>
    <dbReference type="KEGG" id="mxa:MXAN_0436"/>
    <dbReference type="HOGENOM" id="CLU_201842_0_0_7"/>
    <dbReference type="OMA" id="KSPQPYP"/>
    <dbReference type="OrthoDB" id="2036433at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="90" mass="9151" checksum="1246B129D7039052" modified="2006-07-11" version="1">MPGAHFGGGPQVGGKEAAMSKKDVLHIPPEAIPTAPDRNADTEDEERSPRGSPPALQPEGGPAGTPGTGGSQRIIEPVKSPQPYPGFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC8</accession>
    <name>Q1DFC8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550509.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0371"/>
    <dbReference type="EnsemblBacteria" id="ABF92616">
        <property type="protein sequence ID" value="ABF92616"/>
        <property type="gene ID" value="MXAN_0371"/>
    </dbReference>
    <dbReference type="GeneID" id="41357870"/>
    <dbReference type="KEGG" id="mxa:MXAN_0371"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735342_0_0_7"/>
    <dbReference type="OMA" id="CQEDTSK"/>
    <dbReference type="OrthoDB" id="1219958at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="42019" checksum="B9D23F4D7CFF5C7A" modified="2006-07-11" version="1">MPPPDARQSASKSFAGRSTPADPGSSEAVLQECEALEAEVAVLRNLYEQYFLGNERQAPSRAHEDLKKRMNKLKGAFIRSTSAKFRVAGLYNKFLTYERLWMRTLQEIEAGTYRRDVFKARRRAETRKAGATGTAGQKGVVELPEDISDMDFEEVEELIRPRPVNEPQVAASFLQATGGAPSKGPPAVAPLTPAIAPLTPAVGSTPLRGAPAVAPLTGIPSVAPVAGTPPRGQPTVTPAAGGTPAHGTSVAPPGMAAKAPGAVASTPPPSRTSAVGASSTPPPSRPVATGAGSMAPPPRAPGTGTAGNIPPPSRPASMPPSSAASRPPSASGGGGLADDKLRAVYDAYVTAKRRCQEDTSKLSYESVAATLRKQVPELLKQHNAKAVEFKVVIKDGKASLKAVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN5</accession>
    <name>Q1DFN5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0257"/>
    <dbReference type="EnsemblBacteria" id="ABF89386">
        <property type="protein sequence ID" value="ABF89386"/>
        <property type="gene ID" value="MXAN_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0257"/>
    <dbReference type="HOGENOM" id="CLU_112879_0_0_7"/>
    <dbReference type="OMA" id="ARGMFFQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="23931" checksum="937AE9AA5E4D8D73" modified="2006-07-11" version="1">MAVCSPGALEGPLGEMTMYAGYESSAGGGAAWELELRRLAATDDDMARGMFFQGTLDVVGFLGGEGAVARCKGVAGIWEINLLHMYPITRFLRMSSTAARLLAPQLDGFEGVLRRMGTQATVDFVASVFGRELMQAASGKPRLLLQSLGEAYLAAVTYGERYPLWTGETSARFIMRRDFMPAAYHEGVLHGVLEAVGAREVRVHGRQVGLLDSEYELSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG50</accession>
    <name>Q1DG50_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550237.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0090"/>
    <dbReference type="EnsemblBacteria" id="ABF87302">
        <property type="protein sequence ID" value="ABF87302"/>
        <property type="gene ID" value="MXAN_0090"/>
    </dbReference>
    <dbReference type="GeneID" id="41357597"/>
    <dbReference type="KEGG" id="mxa:MXAN_0090"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091687_0_0_7"/>
    <dbReference type="OMA" id="HFANKQG"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041479">
        <property type="entry name" value="TetR_CgmR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17937">
        <property type="entry name" value="TetR_C_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21637" checksum="B18E52F166150E61" modified="2006-07-11" version="1">MFRAVTSAHQRKKQPDVIRAQLLRAAAELVTQGGTQAVTLEAVAAHAGVTKGGLQHHFKSKQLLLDALFEEMNRQFVESFHANIAEDPEAHGREARAYLRAMVSSPANSEQIRGLRALIGSMMVEPDLRERWNCSWQDDLQLKSGEVSPQDINSIICRLATDGLWFADLLEDQGIRPEVRAAVIRRLEELTRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>P95333</accession>
    <accession>Q1CXT4</accession>
    <name>GRPE_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="synonym">grpS</name>
        <name type="ordered locus">MXAN_6672</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5357" last="5368">
            <title>A chaperone in the HSP70 family controls production of extracellular fibrils in Myxococcus xanthus.</title>
            <authorList>
                <person name="Weimer R.M."/>
                <person name="Creighton C.X."/>
                <person name="Stassinopoulos A."/>
                <person name="Youderian P."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="9765567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="U83800">
        <property type="protein sequence ID" value="AAC64204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P95333"/>
    <dbReference type="SMR" id="P95333"/>
    <dbReference type="STRING" id="246197.MXAN_6672"/>
    <dbReference type="EnsemblBacteria" id="ABF93128">
        <property type="protein sequence ID" value="ABF93128"/>
        <property type="gene ID" value="MXAN_6672"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6672"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_1_7"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000113905" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC64204." evidence="3" ref="1">
        <original>S</original>
        <variation>T</variation>
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC64204." evidence="3" ref="1">
        <original>ER</original>
        <variation>NP</variation>
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC64204." evidence="3" ref="1">
        <original>Q</original>
        <variation>L</variation>
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC64204." evidence="3" ref="1">
        <original>GV</original>
        <variation>AL</variation>
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC64204." evidence="3" ref="1">
        <original>A</original>
        <variation>P</variation>
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="255" mass="27411" checksum="46EF5914CD9F1045" modified="2006-09-19" version="2">MTVIEVEASGPSTPVEAEASASPADTTSPPSDAEATPSEDVAALRQEVESLKAQLEFSQAKGRETMERLREAHERAKEAQERTVRHAADLENYRKRAQKEKEEVQRFGSEKLLKDLLPVMDNLDRAIDAAAKSPDLDSFEKGVAMTRKSFEDALGRHGVKGFSAKGQVFDPRVHEAIQQVETADVPAGHVAYEVVRGFYLNERLVRPAMVVVARAPAEPVAAAEPPAVAEPATATTDTEAPAAPAQSENSSGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVP6</accession>
    <name>Q1CVP6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chain length determinant family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557332.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7421"/>
    <dbReference type="EnsemblBacteria" id="ABF92693">
        <property type="protein sequence ID" value="ABF92693"/>
        <property type="gene ID" value="MXAN_7421"/>
    </dbReference>
    <dbReference type="GeneID" id="41364576"/>
    <dbReference type="KEGG" id="mxa:MXAN_7421"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_595493_0_0_7"/>
    <dbReference type="OMA" id="VETRMLT"/>
    <dbReference type="OrthoDB" id="414538at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="507" mass="56115" checksum="FEC03B39C84F9060" modified="2006-07-11" version="1">MTVPAPGAPGPRPQLVPPRPAFTPERPETNAPADLIDWGFAIDAVFFLKNAVLRHWFLALVVMGAVSAMAVGVSKIMPRKYRVETRMLTQRNFIISSLANPGRSIPVDADQPTRAAWEMVMKHDNLKSIVAQAKLVEYWELQRSPLNRLKEKVLRKPPVAMSDDDKRDALTAMLEQAMIVGVEGGTGTVSIGVEWTDPQLALNIVQAAQQNFLDMRQAAEMGAVQEAITILEKQVVEEAAGIQQAIGQLNAAVKRVEARQKKEEEKKGRRGGAAAAANAALGINTDHLLAQMRFMIQTKRRAIGDVEDFRSRRLTELRNQLSEQRVIYSPQHPIITDLEQRISSLQEDSPQLIALRSEMTELINEYVRNGGDPGELESGLATAAMGGATFGGPATSDDPEVSVAADRVRMLVMRHQEKMRRLDQARTELEISRASMKHRFSVLSPPTFPERPSKPKVKLIVAAGVVGGIGMGIFAALALDIIRRRILEKWQVERILKLPVLAELERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV2</accession>
    <name>Q1CVV2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_7363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1575561">
            <id>Q1CVV2</id>
        </interactant>
        <interactant intactId="EBI-1574084">
            <id>Q1CXR8</id>
            <label>MXAN_6688</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557276.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CVV2">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7363"/>
    <dbReference type="EnsemblBacteria" id="ABF88301">
        <property type="protein sequence ID" value="ABF88301"/>
        <property type="gene ID" value="MXAN_7363"/>
    </dbReference>
    <dbReference type="GeneID" id="41364524"/>
    <dbReference type="KEGG" id="mxa:MXAN_7363"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_7"/>
    <dbReference type="OMA" id="IGHYCFM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
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    </dbReference>
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            <end position="830"/>
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    <sequence length="842" mass="91789" checksum="1D2899BCB2CC3B66" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03805">
        <property type="entry name" value="beta_helix_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187716" description="Beta_helix domain-containing protein" evidence="2">
        <location>
            <begin position="43"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="183"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="56132" checksum="4AEE279CE91D4C4E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ3</accession>
    <name>Q1CWQ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_7057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556976.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7057"/>
    <dbReference type="TCDB" id="2.A.1.24.4">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92303">
        <property type="protein sequence ID" value="ABF92303"/>
        <property type="gene ID" value="MXAN_7057"/>
    </dbReference>
    <dbReference type="GeneID" id="41364232"/>
    <dbReference type="KEGG" id="mxa:MXAN_7057"/>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_3_0_7"/>
    <dbReference type="OMA" id="WAFYDWA"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="244"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="48187" checksum="5C47718C48BF9489" modified="2006-07-11" version="1">MRGLLSRIGLTRPALRAWAMYDWANSAFITTVVTVVFPLYYASVAAEGLPREVATSRFATATAVALSVVAVLSPVLGALSDRAGRIKHMLGIFAGLGMVSTLALATVGPGDWAWGLLLFGLGNVGVTGSIVFSDALLRHIARDDELDRVSTAGYALGYLGGGLLLAAQLVLLMKPQWFGLADAGAASRVAFASVAVWWALFSVPLFRRIPEPKPDVSIQRPPLSLRGIFTQLAGTLGGLRQHRQAFLLLVAYLLYSDGIGTIIRLSTLYGTELGIGRGALIGALLLTQVVGVPCAVLFGRAAGRVGVKRALMFALSVYVGVTFLGYFMRTPVHFFALALLVGMVQGGSQALSRSLFAQMVPRDRAAEFFGLFSVFEKVTAVAGPLVFAATVELTGSSRQAVLSLLFFFVSGAAVLSRVDVAAGRRAAREAEARAGWRGDGAPEATAAPEGAPDASRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWZ3</accession>
    <name>Q1CWZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556886.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6965"/>
    <dbReference type="EnsemblBacteria" id="ABF88516">
        <property type="protein sequence ID" value="ABF88516"/>
        <property type="gene ID" value="MXAN_6965"/>
    </dbReference>
    <dbReference type="GeneID" id="41364143"/>
    <dbReference type="KEGG" id="mxa:MXAN_6965"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="DSKVMRD"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13681" checksum="7622B573555FB4BB" modified="2006-07-11" version="1">MADVLVVDDSKVMRDMVVACLRPYPGLTFSHASSGLEAIERLSLQPCDLLVLDLNMPDIGGIEVVEFVRGQDRLRELPIIIVTTRGDEASRTRALAAGASRFMTKPFTPDAILSEVRGLLEGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXB7</accession>
    <name>Q1CXB7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556764.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6839"/>
    <dbReference type="EnsemblBacteria" id="ABF87645">
        <property type="protein sequence ID" value="ABF87645"/>
        <property type="gene ID" value="MXAN_6839"/>
    </dbReference>
    <dbReference type="GeneID" id="41364028"/>
    <dbReference type="KEGG" id="mxa:MXAN_6839"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133057_0_0_7"/>
    <dbReference type="OMA" id="QRFDCDD"/>
    <dbReference type="OrthoDB" id="1712972at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="27473" checksum="E17E480B6A3DE963" modified="2006-07-11" version="1">MHLHHGWRLPVPATCGARLTKGSLIMKLTQRPLCSAFLGLVLAACGPMDDTGQDFTSEQEQPLEATCASVDNTAMTTHACAHASNPGDNVNVNGVTGAPDISTQHKHYTVTLSGSGTGKVTYIPVARASAGSTVESVAFYATQNVTITAVDKSVTPNVTLTALVSTNGITEDTCTLHHARVFDLTVGHTYELNITAPTTSVGMVPEYLYDNRGRYYRDADGDGYGANSPLYRFACEAPAGYVTQRFDCDDTNPAIFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXD6</accession>
    <name>Q1CXD6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6820"/>
    <dbReference type="EnsemblBacteria" id="ABF88208">
        <property type="protein sequence ID" value="ABF88208"/>
        <property type="gene ID" value="MXAN_6820"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6820"/>
    <dbReference type="HOGENOM" id="CLU_1401170_0_0_7"/>
    <dbReference type="OMA" id="NPMKNPM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187964" evidence="1">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="21148" checksum="A6E11DFBBC3D659D" modified="2006-07-11" version="1">MMMRALLLPCVLLLSACSAEIAIQTEPFDQVVPVTSLLEPVYAEVALDLPEESVNTQDLDIIVNEVSATLVVVNPSPTLTLRTSARLSLTGTATPDNPRLYTNFNRPAYYDTAAEILAERTFQPDSRTPLRIDAPALKNAIGRRRVWVIVSNTVVRSGLTLPQLPAQIRLEDIVFQALLTKPFPGLGGALEAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXN8</accession>
    <name>Q1CXN8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6718"/>
    <dbReference type="EnsemblBacteria" id="ABF88150">
        <property type="protein sequence ID" value="ABF88150"/>
        <property type="gene ID" value="MXAN_6718"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6718"/>
    <dbReference type="HOGENOM" id="CLU_976003_0_0_7"/>
    <dbReference type="OMA" id="DWDAHDR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29481" checksum="F7A2BBDE4191876A" modified="2006-07-11" version="1">MDLRAVPAGTHRLRHAHSPAPGDDMKFQCDACERLVPLETYRTEAGGLVVTCGRCGADSRVGPPATTAPRTEVPAVLAAGAAPAPLVPVAPPSDSWSASAPVTPALRVVRSESAPLTDDALFEPPPGVCPKCVAPRREEALSCPQCGLVYVNYQPEEHPLSDVLADAWRKLAARWEDWDAHDRLMTLAVGRGELAMVGRLYRIRLARAPDDAVARRGRDEVVRRATLVVPSSVEPAGTPNVFRRLKTVAVGVGFIVVLVLAVLVFQHLRTLSAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ0</accession>
    <name>Q1CXZ0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556541.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6615"/>
    <dbReference type="EnsemblBacteria" id="ABF85971">
        <property type="protein sequence ID" value="ABF85971"/>
        <property type="gene ID" value="MXAN_6615"/>
    </dbReference>
    <dbReference type="GeneID" id="41363813"/>
    <dbReference type="KEGG" id="mxa:MXAN_6615"/>
    <dbReference type="eggNOG" id="ENOG502ZGQB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063685_0_0_7"/>
    <dbReference type="OMA" id="KSEMFGV"/>
    <dbReference type="OrthoDB" id="1387983at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023894">
        <property type="entry name" value="Sporulation_SdpB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04033">
        <property type="entry name" value="export_SdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF85971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="35775" checksum="43E55B9422D8A037" modified="2006-07-11" version="1">MLTALGNRARAWVAGPSPWSNVYGLARTLVALGTGGTLAFSDTTTLFRPVAGIPEAPVCEGIRAASFFCVLPSGWLEVARWAAVLLLLVVASGWRPRVTGLVHWWVAVSMPWSASLTDGGDQIAAILALLMLPLALTDDRRWHWDTPRESTGNDEAKRLIARSAWVMLRLQVAGIYFHASVGKFKVTEWVDGTALYYWLLDPSVGAPDWLAGVMLPVLSSPVVALLTWSVLLLELGLALGPLLNPSLRRVLLPLGISFHLGIAVFHGLISFVLVMCGALILLLRPFDELFRFEGLRAWVRHMRTPPVPTATPSLEPVAVQVASVPPTDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ5</accession>
    <name>Q1CXZ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556536.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6610"/>
    <dbReference type="EnsemblBacteria" id="ABF88400">
        <property type="protein sequence ID" value="ABF88400"/>
        <property type="gene ID" value="MXAN_6610"/>
    </dbReference>
    <dbReference type="GeneID" id="41363808"/>
    <dbReference type="KEGG" id="mxa:MXAN_6610"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_3_1_7"/>
    <dbReference type="OMA" id="RAGQAMI"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="59"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="37805" checksum="25D080C7B9F37DC0" modified="2006-07-11" version="1">MESAAPDSLPVPDASGDDLRAVEELAQARNEIVAQIEKRVVGQREVVEHLLISLFSRGHCLFVGVPGLAKTLLISTLADVLNLSFNRIQFTPDLMPSDITGTDILEEDRTTGRRTFRFLQGPLFANIILADEVNRTPPKTQAALLQAMQEYRITAGGRTYPLELPFLVFATQNPIEQEGTYPLPEAQLDRFMFLVDVGYPTADEEVQIVKSTTGGPQPKLEKILSPERILALQELVRRVPVPDHVVRYAVELVRHTRPKEPGALDFIAKNTSWGAGPRASQYLVVAAKARAILHGRFVATVEDVRALARPVLRHRVLPNFTAESEGITSVKLIDQLLTVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYT2</accession>
    <name>Q1CYT2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queF</name>
        <name evidence="3" type="ORF">MXAN_6316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6316"/>
    <dbReference type="EnsemblBacteria" id="ABF86984">
        <property type="protein sequence ID" value="ABF86984"/>
        <property type="gene ID" value="MXAN_6316"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6316"/>
    <dbReference type="eggNOG" id="COG0780">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102489_1_0_7"/>
    <dbReference type="OMA" id="LECKEFT"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027377">
        <property type="entry name" value="Nitrile_oxidored_QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14987" checksum="E33252B1991098CC" modified="2006-07-11" version="1">MTRGVGVVDDSAMPSQPSKELQTFPNPAADRDYEIVFDVPEFTCLCPLTGQPDFARFKITYVPDQSCIELKSLKLYMWAYRNEGAFHEKVTNTIADDIIKAIQPRKLTVVGDFFVRGGIGTIVTVTHDKSKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ06</accession>
    <name>Q1CZ06_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556180.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6238"/>
    <dbReference type="EnsemblBacteria" id="ABF92373">
        <property type="protein sequence ID" value="ABF92373"/>
        <property type="gene ID" value="MXAN_6238"/>
    </dbReference>
    <dbReference type="GeneID" id="41363460"/>
    <dbReference type="KEGG" id="mxa:MXAN_6238"/>
    <dbReference type="HOGENOM" id="CLU_1077003_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="27575" checksum="64E423ABFA7B2B51" modified="2006-07-11" version="1">MYDPHRNKAMQPKGRVLRYAVNDMTAATQGDGVARFLPLDAGTYTVTVDGLSAVDDLLLNPGAREQPVILNTCPVCLVPVEVGARPEFLLQWKHDAAGVSGVELTLGDAHPLAQATGTSGLAGWSGEPLVPGPYPLALRFAGGGKFQLYSATGQLLDAAPVLNIPAGRFRFHYQVQQLGQLKLAVQLQQPDGTMAPIDRPHVTVQWPPSASPKEWVLDQGVSEDIPLVNGPQTALTLDALELEDDGAPEVFEFMALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ42</accession>
    <name>Q1CZ42_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556144.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6200"/>
    <dbReference type="EnsemblBacteria" id="ABF87693">
        <property type="protein sequence ID" value="ABF87693"/>
        <property type="gene ID" value="MXAN_6200"/>
    </dbReference>
    <dbReference type="GeneID" id="41363428"/>
    <dbReference type="KEGG" id="mxa:MXAN_6200"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_3_7"/>
    <dbReference type="OMA" id="GCGTLWL"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="378" mass="39193" checksum="E977018DAE02A268" modified="2006-07-11" version="1">MSAFDCVIVGGGIVGAALADVLSADGVSVALVEARSIGAGTTACGMGHLVAMDDNAAELALTSWSVSLWRELADGLPRAVEYDACGTLWLAADDEEMAAVSAKVANYRAAGVRAEVLDSAALHEAEPALAPGLVGALRVVDDAVLYPPLAARTFALRAQARGARLMTGSPVRELRPGSVVLSHGEVLTARHIVLAAGVASPALCPGLPISPRKGHLLITRRGAPVVHHQLVELGYLKSAHGTDGASVAFNAQPRVTGQLLLGSSRQPGDATREVDAALLERMLKRAAMFLPGLDGLQALRVWTGLRPATPDGLPLLGPHPEKPWLWLACGHEGLGITTATGSARLVADQLLGHTSAIDARPYSPARFLTVSSRELAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ43</accession>
    <name>Q1CZ43_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556143.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6199"/>
    <dbReference type="EnsemblBacteria" id="ABF87255">
        <property type="protein sequence ID" value="ABF87255"/>
        <property type="gene ID" value="MXAN_6199"/>
    </dbReference>
    <dbReference type="GeneID" id="41363427"/>
    <dbReference type="KEGG" id="mxa:MXAN_6199"/>
    <dbReference type="eggNOG" id="COG3938">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036729_1_0_7"/>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="OrthoDB" id="559014at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="32745" checksum="B84C97D65697FD25" modified="2006-07-11" version="1">MRRIRVIDSHTGGEPTRVVTDGGPELGTGDLASLRERFREKFDAFRKAIVCEPRGSDVMVGALLCPPVSASSVAGIIFFNNVGYLGMCGHGTIGVVKTLEYLGRIGPGVHSLETPVGVVKATLHPDGRVSIANVPSYRWAHDVAVSVPGHGEVRGDIAWGGNWFFLSRATHLPLELSRTPALLAYTSAIKQALSDQGITGEGGAEIDHVELYAPSPTPGVDARNFVLCPGLAYDRSPCGTGTSAKVACLAAEGVLAEGATWVQESILGSRFEARYVRDGARILPTITGTASVNAEATLLVDPTDPFAWGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ78</accession>
    <name>Q1CZ78_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556108.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6164"/>
    <dbReference type="EnsemblBacteria" id="ABF92458">
        <property type="protein sequence ID" value="ABF92458"/>
        <property type="gene ID" value="MXAN_6164"/>
    </dbReference>
    <dbReference type="GeneID" id="41363394"/>
    <dbReference type="KEGG" id="mxa:MXAN_6164"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_3_1_7"/>
    <dbReference type="OMA" id="AWDSFFH"/>
    <dbReference type="OrthoDB" id="1865374at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="191" mass="20894" checksum="D8F9ED1F191127D8" modified="2006-07-11" version="1">MHEYDLIADWYASQRAGRMGVPEVTALAASLPAGAWVLDVGCGTGLPLTRVLLEHGCHVMGVDSSRELLARFQVNFPHVPVSCAPIQSCELHERTFDAAIAWGVLFHLRHEEQEQAIANIARALKPGAAFLFTSGDAHGSIDGEPMNGVPFRYHSYSVDGYRDLLRAHRLALEATHTDPGANVYYLSRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC7</accession>
    <name>Q1CZC7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556060.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6111"/>
    <dbReference type="EnsemblBacteria" id="ABF87767">
        <property type="protein sequence ID" value="ABF87767"/>
        <property type="gene ID" value="MXAN_6111"/>
    </dbReference>
    <dbReference type="GeneID" id="41363346"/>
    <dbReference type="KEGG" id="mxa:MXAN_6111"/>
    <dbReference type="HOGENOM" id="CLU_1282078_0_0_7"/>
    <dbReference type="OMA" id="CPMSVPG"/>
    <dbReference type="OrthoDB" id="1681692at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="22254" checksum="572F91CFB72D9FFB" modified="2006-07-11" version="1">MRIATTAHRSPPSARRTFSKGGLMSKLRFPAALAASAVMCFSVGCSRNAKTSHGGMPPTAQQVPRQNEGLPPNAQAEMKRDCPMDVSGAQARAEDIPEGVALIIVTPETNKVADLQQRSRRMMQFQQEHGTGGSGMAQPPGVDYDEMGGREEPGSAGAPSVPSIASVHDSPEGVVIVYTAVDPARQDKLSSEIHRNAKYLATGKCPGMAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZF7</accession>
    <name>Q1CZF7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556030.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6081"/>
    <dbReference type="EnsemblBacteria" id="ABF88352">
        <property type="protein sequence ID" value="ABF88352"/>
        <property type="gene ID" value="MXAN_6081"/>
    </dbReference>
    <dbReference type="GeneID" id="41363317"/>
    <dbReference type="KEGG" id="mxa:MXAN_6081"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094965_0_0_7"/>
    <dbReference type="OMA" id="FAAHLMV"/>
    <dbReference type="OrthoDB" id="1738709at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="181" mass="19492" checksum="E779108EA305E75A" modified="2006-07-11" version="1">MEATVLDSWVLAEFSTPDALVTATRQMREKGFEGMDTYSPYPLHGGSEALGLPPSRVPFIALCGGLTGVATALAMQTWMNTIDYPLNIGGRPLLSLPAWVPITFELGVLFAAFGIFFGLLGLSRLPQPYHPVFESEEFRTASTHGYWLSVPQATGTDAAPVMDQLKALGATQVTLVTGEKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZH4</accession>
    <name>TRPF_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="1">PRAI</shortName>
            <ecNumber evidence="1">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpF</name>
        <name type="ordered locus">MXAN_6064</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556013.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZH4"/>
    <dbReference type="SMR" id="Q1CZH4"/>
    <dbReference type="STRING" id="246197.MXAN_6064"/>
    <dbReference type="EnsemblBacteria" id="ABF91277">
        <property type="protein sequence ID" value="ABF91277"/>
        <property type="gene ID" value="MXAN_6064"/>
    </dbReference>
    <dbReference type="GeneID" id="41363300"/>
    <dbReference type="KEGG" id="mxa:MXAN_6064"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_2_0_7"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_1000018611" description="N-(5'-phosphoribosyl)anthranilate isomerase">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <sequence length="212" mass="21633" checksum="B9536A7906E8572D" modified="2006-07-11" version="1">MSVRVKVCGVTRLSDAVAAWEAGVDALGLNFYPKSPRYLDLPTAAALARTRPPLGTVLGVFVNAAPDTIRETVRACGLTAVQLHGDEPPEACSGYGVPVIKALRVTGPEDVVRARTYVGVGDVAGLLLDGAAPGYGGGGVGFDWSLVAGLAGSGVPVLVAGGLRPSNVAEAVRATRPYGVDVASGVESAPGIKDVEAVRAFVRAAKSINLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZK7</accession>
    <name>Q1CZK7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis protein methyltransferase CheR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555980.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6031"/>
    <dbReference type="EnsemblBacteria" id="ABF88773">
        <property type="protein sequence ID" value="ABF88773"/>
        <property type="gene ID" value="MXAN_6031"/>
    </dbReference>
    <dbReference type="GeneID" id="41363269"/>
    <dbReference type="KEGG" id="mxa:MXAN_6031"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681353_0_0_7"/>
    <dbReference type="OMA" id="RATYGTW"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="413" mass="44673" checksum="AA669F7C6E4DFBED" modified="2006-07-11" version="1">MSGALDPRLLARAREVVAGITGFRNDAIASEAVDRVVRAELARGRTAPDLLGELLHPVSHLATALVKAILVGETYFFRHPEHFRFISHEAVPAALQRGALALRGWSAGCASGEEAYSLAACLQASLPHGFPVEVLGTDIHEASLEAARRATYGTWSRRESAPRLFPLYSETGEREVTILPPVRRITTFAQANLLAPLPERFGRFDFILCRNVLTYFTPAARDAAITLLSRTLNPGGWLFLGAVEVDRVPAGMVREGPPELQAFRLLTQEELNARAAAASRAAALARPVAAPSRRPVAPLMPAPAREVPVAPPPPPTRLHLNALERIEEGDEVGASSVLEALVRQAPDYLPGLLELALLRERSGAREGAVPLMRALRSRAERLPPDQLVEGPEALPARFYQASADAYLNQGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZS5</accession>
    <name>Q1CZS5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555912.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5961"/>
    <dbReference type="EnsemblBacteria" id="ABF92768">
        <property type="protein sequence ID" value="ABF92768"/>
        <property type="gene ID" value="MXAN_5961"/>
    </dbReference>
    <dbReference type="GeneID" id="41363200"/>
    <dbReference type="KEGG" id="mxa:MXAN_5961"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989810_0_0_7"/>
    <dbReference type="OMA" id="RYHYAVD"/>
    <dbReference type="OrthoDB" id="1742143at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="94"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="32722" checksum="0B69A4C00E8AF8AA" modified="2006-07-11" version="1">MPERLYPHEVLLAAFGIVLSTALVFVAGISATVTAQAVGGTVLFMGSVALLARLDAVAHVFRARLLLAYLATFFFYASVKQAVPALGLVTRDAWLLSADVFLFGITPAAWLQRWSTPWVNELFSASYLAFHGYLHLAMAWALVGPRARAERFFIDVFSAYLPGIAGYYLMPAIGPVAAWPELFTVPIEGGWFTQLNAAVVASGSSTYDLFPSLHTYITLVLLEHDRRQHPWRFRLMVPVAVAILMSTLVLRYHYAVDLLAGAVWFMVFRACFPRLQARWEARTALSKHEAPTVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW6</accession>
    <name>Q1CZW6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB</name>
        <name evidence="4" type="ORF">MXAN_5920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555871.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5920"/>
    <dbReference type="EnsemblBacteria" id="ABF89421">
        <property type="protein sequence ID" value="ABF89421"/>
        <property type="gene ID" value="MXAN_5920"/>
    </dbReference>
    <dbReference type="GeneID" id="41363158"/>
    <dbReference type="KEGG" id="mxa:MXAN_5920"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_0_0_7"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="265" mass="28732" checksum="84DC4A2332D6D947" modified="2006-07-11" version="1">MKILVTAKRVEDPESKIKVKPDGSGIVQEGLKYKINPFDEIGVEEGLRLVAKHQGEVVVVSIGGKEVQEQLRHALAMGAHRAVWVNHTGPVDQLGIAALLQKVVEKEQPDLVILGKQSIDDDQNQVGQYLAEFLGWGQATFASKVESMESEQEKNKVPAIVVSADKKSVQVIREVDNGLATVECQLPAVVTTDLRLNQPRYASLPGIMKAKSKPIEELTPAKLSVDVTPAIQVLKMSAPPARKAGIKVADVPALVEKLHNEAKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0G2</accession>
    <name>Q1D0G2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MJ0042 family finger-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555675.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5723"/>
    <dbReference type="EnsemblBacteria" id="ABF91007">
        <property type="protein sequence ID" value="ABF91007"/>
        <property type="gene ID" value="MXAN_5723"/>
    </dbReference>
    <dbReference type="GeneID" id="41362968"/>
    <dbReference type="KEGG" id="mxa:MXAN_5723"/>
    <dbReference type="HOGENOM" id="CLU_033987_0_0_7"/>
    <dbReference type="OMA" id="QGMADWK"/>
    <dbReference type="OrthoDB" id="679274at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="GYF_2" evidence="4">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="577" mass="61588" checksum="B7F97F064134EF35" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0G6</accession>
    <name>Q1D0G6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ORF">MXAN_5719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5719"/>
    <dbReference type="EnsemblBacteria" id="ABF87131">
        <property type="protein sequence ID" value="ABF87131"/>
        <property type="gene ID" value="MXAN_5719"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5719"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_7"/>
    <dbReference type="OMA" id="KRGIGNE"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="23342" checksum="A2A0D2FFF64009E3" modified="2006-07-11" version="1">MDTVRSHADLAPYIDHTLLKPEARAEDVVKLAEEARQYGFATVCVNSTHVATAARVLAGSSTVPIAVVGFPLGASLPSAKAFEARESIRAGAREIDMVLNVGALKAHDYALVHQDIAAVVEASRPVPVKVILETALLTDEEKVIACSLSKAAGAAFVKTSTGFGPGGATEADVALMRRVVGDTVGVKASGGIRSAEDAMKMLRAGANRVGASASVAIVSGQTSSAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0I2</accession>
    <name>Q1D0I2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555655.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5703"/>
    <dbReference type="EnsemblBacteria" id="ABF90083">
        <property type="protein sequence ID" value="ABF90083"/>
        <property type="gene ID" value="MXAN_5703"/>
    </dbReference>
    <dbReference type="GeneID" id="41362948"/>
    <dbReference type="KEGG" id="mxa:MXAN_5703"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122998_0_0_7"/>
    <dbReference type="OMA" id="MNESIAM"/>
    <dbReference type="OrthoDB" id="941029at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="27538" checksum="757F6A3AC11AC1D4" modified="2006-07-11" version="1">MWQRFKRAMRSFAGFFVSSIEDPELILEQNVRDLNDQVPKMNESIAMVRANVTLLEKENAKYQDDVRSLTAKVKAAIQAGRDDLAAQYASKLQIEKDALARNEQQLATARQAYEKALSVKKAFMREKERKTQEAMNAIREARRAKWQAKVADTMESFTVAGIDSTHDEMLRKVQEKSAINEARMQMALESVDHTAASIEEEAEKIQANELVKQFKMEMGLVSSPAPVSEVGSGPEKTIGKKVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T4</accession>
    <name>Q1D0T4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division protein FtsQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsQ</name>
        <name evidence="9" type="ORF">MXAN_5600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555554.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5600"/>
    <dbReference type="EnsemblBacteria" id="ABF90535">
        <property type="protein sequence ID" value="ABF90535"/>
        <property type="gene ID" value="MXAN_5600"/>
    </dbReference>
    <dbReference type="GeneID" id="41362846"/>
    <dbReference type="KEGG" id="mxa:MXAN_5600"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047677_3_0_7"/>
    <dbReference type="OMA" id="FKRVTPG"/>
    <dbReference type="OrthoDB" id="1270665at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35851">
        <property type="entry name" value="PTHR35851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="32596" checksum="DAC1C6F485EF4329" modified="2006-07-11" version="1">MAPEPGTACVNPFLPMAFGKSKNRRRQDAAQQKEAVRGAVRSHGPGVLKVLGLTLGTGLLVWGGVALREWALTSPRFELEAVSFSGLQRASRVELLRLAALTKGQNLWTLDVDALERAMHQHPWLRTVEVTRRFPNRVSVEVTEHVPVAMAVLGELYVLDEEGEPFKRVTPGDGLDLPLVTGLDREGYVADPAVARERLRSALTVASAYARLSPEKAEQLSEVRLEALSLALVTASGQEVRLGEGDSEVKLQRLARVRRELGARGLAAEIIHLDNRARPGWVAVKISSPASERSGASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F5</accession>
    <name>Q1D1F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YdjC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555333.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5368"/>
    <dbReference type="EnsemblBacteria" id="ABF90990">
        <property type="protein sequence ID" value="ABF90990"/>
        <property type="gene ID" value="MXAN_5368"/>
    </dbReference>
    <dbReference type="GeneID" id="41362636"/>
    <dbReference type="KEGG" id="mxa:MXAN_5368"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_2_0_7"/>
    <dbReference type="OMA" id="DFELGCH"/>
    <dbReference type="OrthoDB" id="1204930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30012" checksum="28B53762F1AD410D" modified="2006-07-11" version="1">MTRPLTRLVVNADDLGLHASLDAGILRAHRDGIVTSATLLATGPTAPEAAARAKEARLAVGLHLALSTRLPPAAPAHEVPTVAPEGRLRGSWADFARAWLTGQVRRDELARELSAQLQRARALGVTVDHLDGHQHLHLLPGVRPLVESLAAREGLPLRWPDALPRPRWLKAPGPALKATVLAVLARAAPRAPKGVRRVSAGGVFEAGMLDEAALLAVVDALPAGDFELGCHPGEGTPHVPEDPAWRYGWQAELAALTSARVKARLHERGIELHSYGTLFSAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H8</accession>
    <name>SECA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">MXAN_5345</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">May bind 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555310.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D1H8"/>
    <dbReference type="SMR" id="Q1D1H8"/>
    <dbReference type="STRING" id="246197.MXAN_5345"/>
    <dbReference type="PRIDE" id="Q1D1H8"/>
    <dbReference type="EnsemblBacteria" id="ABF88484">
        <property type="protein sequence ID" value="ABF88484"/>
        <property type="gene ID" value="MXAN_5345"/>
    </dbReference>
    <dbReference type="GeneID" id="41362614"/>
    <dbReference type="KEGG" id="mxa:MXAN_5345"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_7"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
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        <property type="entry name" value="SecA"/>
    </dbReference>
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        <property type="entry name" value="SecA_CS"/>
    </dbReference>
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        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
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        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
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        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
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        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
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        <property type="entry name" value="SecA_DEAD"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000318396" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="879"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="923"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="932"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="933"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="940" mass="106305" checksum="030961B1239B7ED3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L7</accession>
    <name>Q1D1L7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5305"/>
    <dbReference type="EnsemblBacteria" id="ABF92997">
        <property type="protein sequence ID" value="ABF92997"/>
        <property type="gene ID" value="MXAN_5305"/>
    </dbReference>
    <dbReference type="GeneID" id="41362575"/>
    <dbReference type="KEGG" id="mxa:MXAN_5305"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006325_2_0_7"/>
    <dbReference type="OMA" id="NAELCNA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="833"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="902" mass="100663" checksum="639E7CCC8096C64A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R6</accession>
    <name>Q1D1R6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5255"/>
    <dbReference type="EnsemblBacteria" id="ABF89400">
        <property type="protein sequence ID" value="ABF89400"/>
        <property type="gene ID" value="MXAN_5255"/>
    </dbReference>
    <dbReference type="GeneID" id="41362533"/>
    <dbReference type="KEGG" id="mxa:MXAN_5255"/>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1784802_0_0_7"/>
    <dbReference type="OMA" id="CIYRTAT"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188026" description="YCII domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="YCII" evidence="3">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15863" checksum="1006CC97B8FEB484" modified="2006-07-11" version="1">MTLTTALLLLTLGAAPAQPAAKKFEFDRHYLVLLERVPGAKKLPEAELAQLQKEHLAHLTRMGESGKMVLAGPFDEQDDVGMRGACIYRTATKAEAKQLAEQDPMVKAGRLKVQVMAWYTEKGYLAFPKAPPVEDAKDVAKDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U2</accession>
    <name>Q1D1U2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">MXAN_5229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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        <property type="protein sequence ID" value="ABF92406"/>
        <property type="gene ID" value="MXAN_5229"/>
    </dbReference>
    <dbReference type="GeneID" id="41362510"/>
    <dbReference type="KEGG" id="mxa:MXAN_5229"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_1_7"/>
    <dbReference type="OMA" id="SHTELDR"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
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        <property type="entry name" value="GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="257"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="288"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="476" mass="52113" checksum="C14FFF78629FF7B3" modified="2006-07-11" version="1">MRMAISTFPERLRAVLVGVQLPGVSDEEHAADFAELRRLVHTLGYDTVATVSQKRTRLATGTVLGTGKLKELAALTGGSGVIASGASDRTSKAREKWEAAANTEPDSEDEVVEEEADGVETEDALLPPPSEEDDKAEPRPTVVVVDHELSPGQLRNLEKATGAMVLDRAGVIVDIFHRHAKSHEARMQVEIARLNYLAPRLRESTGGRERQQGRGAGDSALELDRRKIRDRLAELREGLAAIQKDQDHRRYARRDLLRVALVGYTNAGKSSLMRALTGSTVLVADQLFATLDTTVRAMQPETRPRILVSDTVGFIQKLPHDLVASFRSTLDEALEASLLLYVVDASDPTWAAQLEVTRTVLRDIGADAVPSKLLFNKADRLDAAAKEALLAKHPDALLLSAHLPDDVAMLRKNIIAFFESSMVEADLVIPYSRQGRISEVYEHTTVVSQAYDESGSRLRVRGLPGAIAKLTQSFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V9</accession>
    <name>Q1D1V9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555180.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D1V9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5212"/>
    <dbReference type="EnsemblBacteria" id="ABF91565">
        <property type="protein sequence ID" value="ABF91565"/>
        <property type="gene ID" value="MXAN_5212"/>
    </dbReference>
    <dbReference type="GeneID" id="41362494"/>
    <dbReference type="KEGG" id="mxa:MXAN_5212"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_000445_30_1_7"/>
    <dbReference type="OMA" id="HLEDKDR"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
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    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
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    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="24665" checksum="158929528D23F9D0" modified="2006-07-11" version="1">MRALLVEDEPELARLVANEATSQGFSVDAVASVTEARSAIHLGAYAIVLLDRRLPDGDGLCLIPELRAMQPEAGVLVISAMGDVPERVAGLDAGADDYMGKPFHADELRARIRSVLRRPAQARQLQPVRCGAIEYDLGSRQMTVQGRPLLLRRREASLLAALMRRARRVVQRDTLIKEVYGFDEEPSANTLEAHISRLRRRLEDCGAGVVLHPVRGVGYLIDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W0</accession>
    <name>Q1D1W0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574283">
            <id>Q1D1W0</id>
        </interactant>
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
            <label>MXAN_2606</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555179.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D1W0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5211"/>
    <dbReference type="EnsemblBacteria" id="ABF89565">
        <property type="protein sequence ID" value="ABF89565"/>
        <property type="gene ID" value="MXAN_5211"/>
    </dbReference>
    <dbReference type="GeneID" id="41362493"/>
    <dbReference type="KEGG" id="mxa:MXAN_5211"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_37_7"/>
    <dbReference type="OMA" id="PIAIMQT"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="212"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="273"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="490" mass="52415" checksum="FE1D0A9020A9069F" modified="2006-07-11" version="1">MKRLTDSLAPRLIAAVLATQLIVITGLMLFWMVFSHSVSHDDLSAATSQRRVAESITLDPAGAPRIEPSSALRAYQARRPQLAYAVYLDGRLVSGSSQQLAHAISPRGWAAPGANLEPAPTLADLYRHFPDLQCVQLLAECGDPVIALGEGQRANVSMFPIHGIGTAVVVTSGNRLGLDDLPTALLTLIPRVMKLFGSAVLATVLVLPLMLRRALQPLTRAANAASGIGLETLDQRLSPDGVPKEIQPFVTAINQLLERLERGVSRQQLFVANAAHELRTPVAILCARLDSLGDSPATRDLRRDATRLGLMVDQLLAAFRMQGQTPADWRALDLVQQLRDLISDMAPLALRSGRAIALEAASPSEMVLGQADGLRSALANLLDNALRAEPAGGTVIVRMEASTSSVTVDVVDHGPGVEESDRENIFEPFWRREGQWSGTGLGLAIARRISEGHGGSLQHLPTEGGGATFRMRVGRSPAGRSIDPSACCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W5</accession>
    <name>Q1D1W5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA-[protein]-cysteine S-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5205"/>
    <dbReference type="EnsemblBacteria" id="ABF90311">
        <property type="protein sequence ID" value="ABF90311"/>
        <property type="gene ID" value="MXAN_5205"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5205"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_6_7"/>
    <dbReference type="OMA" id="WREQSQR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="16072" checksum="44A22B25D9A8C12C" modified="2006-07-11" version="1">MGPRSIRGPGAFVFLESGAVALRAKTKTPKAEVKKAPLPFSKAVWKAVRAIPRGQVRSYAQVALYAGRPGAARGVGREMATLPQQPELPLPWWRVTRSDGTLAPQVAQEQARRLRAEGVEVTQRGDTFRVKVPREVPAPGLATKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y3</accession>
    <name>Q1D1Y3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5187"/>
    <dbReference type="EnsemblBacteria" id="ABF88116">
        <property type="protein sequence ID" value="ABF88116"/>
        <property type="gene ID" value="MXAN_5187"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5187"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374215_0_0_7"/>
    <dbReference type="OMA" id="CKTVRFQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="742" mass="75506" checksum="D4EF5FA798720658" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D231</accession>
    <name>Q1D231_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555111.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5138"/>
    <dbReference type="REBASE" id="13176">
        <property type="entry name" value="M.MxaDKORF5138P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92760">
        <property type="protein sequence ID" value="ABF92760"/>
        <property type="gene ID" value="MXAN_5138"/>
    </dbReference>
    <dbReference type="GeneID" id="41362422"/>
    <dbReference type="KEGG" id="mxa:MXAN_5138"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_5_1_7"/>
    <dbReference type="OMA" id="GTQHVIF"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="32024" checksum="4E0BDC6734EA41CD" modified="2006-07-11" version="1">MSAHAAAAPSLKVVRRSLNESVYAKGEAYTLLHGDSLELMSQFEPQTFDMIFADPPYFLSNGGTTCKGGKRVSVAKGGWDVSRGVEEDHKFTTEWLAACQRLLKPTGTLWVSGTQHVIFNAGFAMQKLGYKLLNTVTWFKPNASPNLACRYFTHSTELLIWASPKSGGKLQHTFNYARMKAENGGKQMRDAWALPPSGDAELTADGEGRMWTLTVPRGGEEKAFGSHPTQKPVALLERILEASCPPDALVLDPFNGSGTSGVAALKLGHRYVGIDMDEKYLALSEKRLNAAASK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D282</accession>
    <name>THIE_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-phosphate synthase</fullName>
            <shortName evidence="1">TP synthase</shortName>
            <shortName evidence="1">TPS</shortName>
            <ecNumber evidence="1">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="1">TMP pyrophosphorylase</shortName>
            <shortName evidence="1">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiE</name>
        <name type="ordered locus">MXAN_5087</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555061.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D282"/>
    <dbReference type="SMR" id="Q1D282"/>
    <dbReference type="STRING" id="246197.MXAN_5087"/>
    <dbReference type="EnsemblBacteria" id="ABF88204">
        <property type="protein sequence ID" value="ABF88204"/>
        <property type="gene ID" value="MXAN_5087"/>
    </dbReference>
    <dbReference type="GeneID" id="41362371"/>
    <dbReference type="KEGG" id="mxa:MXAN_5087"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_2_7"/>
    <dbReference type="OMA" id="ITAFQFR"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000336414" description="Thiamine-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <sequence length="218" mass="22471" checksum="3D292D8805BA609C" modified="2006-07-11" version="1">MNAPSRPHLPRGPYLLCDDSVLPEISLVDKAARLVAGGARLVQLRMKRTPIREALAATRQVVALCRREGALCLVNDRVDLALLADADGVHVGDEDVPAEDARALLGPGRLVGVTVRDVVGARAAQAAGADYVGLGPVFPTSTKQVPAPVLGLEAFASVVRDSPLPVVGIGGVGLVNIASVAAAGAHCAAVVSDALLAADITERVRRLVEAFEQGRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2G8</accession>
    <name>Q1D2G8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol:disulfide interchange protein DsbD</fullName>
            <ecNumber evidence="6">1.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-disulfide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">dbsD</name>
        <name evidence="21" type="ORF">MXAN_4999</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family. DsbD subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554977.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4999"/>
    <dbReference type="EnsemblBacteria" id="ABF88490">
        <property type="protein sequence ID" value="ABF88490"/>
        <property type="gene ID" value="MXAN_4999"/>
    </dbReference>
    <dbReference type="GeneID" id="41362283"/>
    <dbReference type="KEGG" id="mxa:MXAN_4999"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014657_3_1_7"/>
    <dbReference type="OMA" id="YRHRFQF"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022910">
        <property type="entry name" value="Thiol_diS_interchange_DbsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32234:SF0">
        <property type="entry name" value="PTHR32234:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="20">
        <location>
            <begin position="363"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ABF88490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="506" mass="52504" checksum="CFAA647B6FC48369" modified="2006-07-11" version="1">MPLQRSSPWPPACVYKGGLGARSHARMDAKKLGVMAVLAGVAVAVVPWLLPTGPNANLDAARFLEAGSLAVGAAVVFAGGLLTALTPCVYPLIPITVSVFGARKTEGRGRALLLTSSYIVGMGVVFSALGVLAAKTGQAFGSMLGHPAVVTGLAVFLLLLATSMFGAFELALPSSFQTKLNAVGGAGVAGAFLMGSVSGFLAAPCTGPVLTGLLAFVAKSANTTLGASLLFVYALGIGVPFFLIGVFTVRLPRGGVWMEWVKSVLGIMLVALAFSYLKDAFPWARDVVKGLGLHVGRVPGAVIAALLVAVGVALGAVHRSFKEGAREFSFKALGVALVVAALVLRGGALDGGPVGTLWVSLGLAEPARAPAWQWHHVMPAKQATFSPEAFDQVLAQAKAEGRPVLIDFFADWCAACKELDRDTYPAQQVISESDEGRFLNIKIDATNSEDSLDALLERFGVEGLPTVAFISPEGKVLTQPRVTGFLAPSPFATEMKKARCTDANAC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2J5</accession>
    <name>RUVA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">MXAN_4972</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554950.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D2J5"/>
    <dbReference type="SMR" id="Q1D2J5"/>
    <dbReference type="STRING" id="246197.MXAN_4972"/>
    <dbReference type="EnsemblBacteria" id="ABF91402">
        <property type="protein sequence ID" value="ABF91402"/>
        <property type="gene ID" value="MXAN_4972"/>
    </dbReference>
    <dbReference type="GeneID" id="41362257"/>
    <dbReference type="KEGG" id="mxa:MXAN_4972"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_0_0_7"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_1000002496" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="202" mass="21559" checksum="B395B1090DCCBDF6" modified="2006-07-11" version="1">MISRLRGTVLEKDLEDATIDVGGVGYRVNFSSLALGKLPAEGQPVDVRVRTVVREDAFDLFGFLTKGEEEVFLLLNSVSRVGPRLSLMVLSGMEVPELVAALSRGEVARLAKIHGVGKKTAERLVLELKDKVKTIHLEAVSRGTAPAAVSGAHADLVSALLNLGYKQPQAEKAADLASERLGAEATFQALFREALKALRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M4</accession>
    <name>Q1D2M4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554921.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4943"/>
    <dbReference type="EnsemblBacteria" id="ABF88509">
        <property type="protein sequence ID" value="ABF88509"/>
        <property type="gene ID" value="MXAN_4943"/>
    </dbReference>
    <dbReference type="GeneID" id="41362228"/>
    <dbReference type="KEGG" id="mxa:MXAN_4943"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008143_0_0_7"/>
    <dbReference type="OMA" id="WLLGTDM"/>
    <dbReference type="OrthoDB" id="1395551at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="65808" checksum="A3321B6707D423C0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D7</accession>
    <name>Q1D3D7_MYXXD</name>
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        <submittedName>
            <fullName evidence="8">Biopolymer transport protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4670"/>
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        <property type="family name" value="the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88650">
        <property type="protein sequence ID" value="ABF88650"/>
        <property type="gene ID" value="MXAN_4670"/>
    </dbReference>
    <dbReference type="GeneID" id="41361970"/>
    <dbReference type="KEGG" id="mxa:MXAN_4670"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_2_7"/>
    <dbReference type="OMA" id="VAIVTMK"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
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        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="15507" checksum="A0890FC346CA1F43" modified="2006-07-11" version="1">MGMGKTPGSDDGSEDGVFAEINITPLTDIFLVLLIIFMVTSSVIVQQGPGGGAKAGLKVNLPKGGAADVTARTTDLSVAVLADGRFMLAGNVVSQDELQQAFDDARQKDEETVVIVQADEGVPHGTVVQVMELAKKAGLAQLAIGVREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3G9</accession>
    <name>Q1D3G9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase AgmH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">agmH</name>
        <name evidence="2" type="ORF">MXAN_4638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554630.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4638"/>
    <dbReference type="EnsemblBacteria" id="ABF90964">
        <property type="protein sequence ID" value="ABF90964"/>
        <property type="gene ID" value="MXAN_4638"/>
    </dbReference>
    <dbReference type="GeneID" id="41361938"/>
    <dbReference type="KEGG" id="mxa:MXAN_4638"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_7"/>
    <dbReference type="OMA" id="FHGFSDH"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="30813" checksum="CD74F5984FF8045B" modified="2006-07-11" version="1">MARSDEGFFPGRDGTRLYWKSILPDAEPRAHVAVVHGYGDHFGRYGFVTDALLADGFAVHGFDYRGHGKADGRRAYCEKWPDYLEDLEVFWERVRAVSEGKKAFVLAHSHGGLMSATWASSRRVEGLTGLVLSAPYLKLAITPPASKLMAARAVGKLVPWLSISSGLKVEDLTHDTDVQRATREDPLHQAIATPRWFVESTRAQGEAVLLAPKIQVPLFVLCGAEDGVAAPAAAREYFERAGSPDKKFKEYPGMRHEPLNEVGRAEVFRDISGWISAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K5</accession>
    <name>Q1D3K5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4600"/>
    <dbReference type="EnsemblBacteria" id="ABF87774">
        <property type="protein sequence ID" value="ABF87774"/>
        <property type="gene ID" value="MXAN_4600"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4600"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028867_0_0_7"/>
    <dbReference type="OMA" id="EGARGCW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023984">
        <property type="entry name" value="rSAM_ocin_1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00324">
        <property type="entry name" value="bacteriocin_maturation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03975">
        <property type="entry name" value="rSAM_ocin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="2">
        <location>
            <begin position="267"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="675" mass="75643" checksum="B911864C2F6CCED1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3S1</accession>
    <name>Q1D3S1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitinase, class I</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554529.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4534"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="GH19">
        <property type="family name" value="Glycoside Hydrolase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89725">
        <property type="protein sequence ID" value="ABF89725"/>
        <property type="gene ID" value="MXAN_4534"/>
    </dbReference>
    <dbReference type="GeneID" id="41361836"/>
    <dbReference type="KEGG" id="mxa:MXAN_4534"/>
    <dbReference type="eggNOG" id="COG3179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045506_0_0_7"/>
    <dbReference type="OMA" id="FWFWTTQ"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187850" evidence="1">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="51"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="43259" checksum="51EFE8C573D4EFB1" modified="2006-07-11" version="1">MSGKFVSRSLALLGICGGLSALGGCGDAEPVPAALEPVGQVEGAAIVDTITEGTYVIRSVMTNKCIDVASSSTADGAKVQQWDCNGTNAQRFRVTPTSGGYFSIINVNSNKALDIKEASTAANALVHQWGYGGGANQQFRFVKEVGSEFSIRARHTDMAIDVYWGNTANGTELVQYPYEQRTNQRWTFDRIDGGGGNPGTGLAAILSESTFNAMFPNRNPFYTYSSLIAAASTFPAFANTGSLETRKREVAAFFANTAHETGNYVYVEEINRGDYCGSWGPPGCYCVAGKKYYGRGPIQLSWNGNYCAAGAALGLPLHTNPDLLAQDANASWRSAFWFWTTQAGAGTMSAHRAMVDGHGFGETIRTINGSLECNGRNPGQVQSRINNYQHFTNMLGVSPGGNLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U7</accession>
    <name>Q1D3U7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554503.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4507"/>
    <dbReference type="EnsemblBacteria" id="ABF89023">
        <property type="protein sequence ID" value="ABF89023"/>
        <property type="gene ID" value="MXAN_4507"/>
    </dbReference>
    <dbReference type="GeneID" id="41361814"/>
    <dbReference type="KEGG" id="mxa:MXAN_4507"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410328_0_0_7"/>
    <dbReference type="OMA" id="MPDIGAY"/>
    <dbReference type="OrthoDB" id="865306at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="617" mass="67836" checksum="ACA868B12813ECD7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D493</accession>
    <name>Q1D493_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554358.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4357"/>
    <dbReference type="EnsemblBacteria" id="ABF90803">
        <property type="protein sequence ID" value="ABF90803"/>
        <property type="gene ID" value="MXAN_4357"/>
    </dbReference>
    <dbReference type="GeneID" id="41361669"/>
    <dbReference type="KEGG" id="mxa:MXAN_4357"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064194_2_2_7"/>
    <dbReference type="OMA" id="ERGYADH"/>
    <dbReference type="OrthoDB" id="729805at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="25174" checksum="9D652393656F4C7F" modified="2006-07-11" version="1">MIAIRPSEARGHANHGWLDSHHTFSFAGYYDPDFMGFRALRVINEDRVAPHEGFGTHPHRDMEIITYPLSGAIAHRDSTGGEGLLRAGEIQRMTAGTGVLHSEMNGADENLHFLQIWIIPDRKGLTPGYEQKAFPEAERQGRWRVVASPDARDGSLTVHQDVVLHATLLGTGEQATYTLAPGRHAWLQLARGKATLNGVELKAGDGAAVADESQLVLSATEPVEALLFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D494</accession>
    <name>Q1D494_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554357.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4356"/>
    <dbReference type="EnsemblBacteria" id="ABF91331">
        <property type="protein sequence ID" value="ABF91331"/>
        <property type="gene ID" value="MXAN_4356"/>
    </dbReference>
    <dbReference type="GeneID" id="41361668"/>
    <dbReference type="KEGG" id="mxa:MXAN_4356"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_16_2_7"/>
    <dbReference type="OMA" id="GQRLYEV"/>
    <dbReference type="OrthoDB" id="1661500at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="32264" checksum="F203116EECC47AAE" modified="2006-07-11" version="1">MDLNELLVFARVVQAGSFTAAARGLRMPKSTVSRKVSELETRVGAQLLQRTTRKLRLTDVGRTYYEHCARIVAEAEQAELAVTRMQAAPHGLLRVTTPLTFSFIGPLVSTFIKQYPEVQLEMVCTDRNVDLVAEGFDLAIRAGRLADSSLMARRLGIVERVVIAAPSYLKARGTPKAPKDLEKHDCLLFGAGLENNVWTLHSGNRSVDIKVPARIVVNEPDMLYAVARAGSGIALLPNLHFTSELAAGRLQRILPDWSSTGAPVHAVYPSTRHHSPKVMAFVECLREHWPIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F1</accession>
    <name>Q1D4F1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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    <dbReference type="EnsemblBacteria" id="ABF91857">
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        <property type="gene ID" value="MXAN_4297"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_4297"/>
    <dbReference type="eggNOG" id="COG1028">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.129.110">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
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        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Acyl_transferase"/>
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        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
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    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
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    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
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        <property type="entry name" value="PKS_dehydratase_sf"/>
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    </dbReference>
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        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ketoacyl-synt"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="1806"/>
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        <location>
            <begin position="1706"/>
            <end position="1733"/>
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        <location>
            <position position="1766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1829" mass="196406" checksum="11E33E2404933B92" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4G2</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">MXAN_4286</name>
    </gene>
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            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="246197.MXAN_4286"/>
    <dbReference type="EnsemblBacteria" id="ABF89068">
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        <property type="gene ID" value="MXAN_4286"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="69"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="442" mass="49781" checksum="AADB82AEB9F7F5AE" modified="2006-07-11" version="1">MPTLEIATRFDWDTFVRRYWNQRPVLFKGTQASPFTVDDVFEASAGATQRYLSRSYEPASRPDVTFTVDRLRQLRSREWLPRKSDGSLDGYDARIASQLGERRYALIIATMHASGFQLWSRQRAFFSGLWQRVGMPVTGGITSLFHGTYEHSPVGVHLDRFTTFMFALRGRKRMRFWHKRPWSEDVSTILDYQPYLASSFVAEVEPGDILYWPSTYYHVGESAGAGVASSLNVGIPITEHHVIYSVDDLLRGMLDETSLADQEWKQTRLARVSASPLARGALSKNGVLATELPRALTEAVRAFRDVSHPKEARRHIQSTWLKRLTSGGFEPVPPPTREKPLRDSHHVRVDPSFPVLFERDSATRWICSANGHALRGAGGGRAIEIFFRKLNSGAAVSVEELLSPFGTRRAARHDSEVIAATREGMRGVLKKLHAVRAITLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D530</accession>
    <name>Q1D530_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554072.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4065"/>
    <dbReference type="EnsemblBacteria" id="ABF91485">
        <property type="protein sequence ID" value="ABF91485"/>
        <property type="gene ID" value="MXAN_4065"/>
    </dbReference>
    <dbReference type="GeneID" id="41361395"/>
    <dbReference type="KEGG" id="mxa:MXAN_4065"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_3_0_7"/>
    <dbReference type="OMA" id="AVWHSHV"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="15322" checksum="4FCEE732211FBB5A" modified="2006-07-11" version="1">MSHWPEHILDEVGRHLEAAYPFEGCGVILRAEGSGALRIRPLRNAADNPRVAYAFAPEEWLAVCMDADVRSERVVCVFHSHVDAPATFSREDLLRAAPEGHPLLPDVSYLIGSVHRGCVHYVSEYEWLEGNFVLRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D591</accession>
    <name>Q1D591_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554012.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4002"/>
    <dbReference type="EnsemblBacteria" id="ABF92114">
        <property type="protein sequence ID" value="ABF92114"/>
        <property type="gene ID" value="MXAN_4002"/>
    </dbReference>
    <dbReference type="GeneID" id="41361333"/>
    <dbReference type="KEGG" id="mxa:MXAN_4002"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_9_7"/>
    <dbReference type="OMA" id="THFFEHP"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="602"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1669"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1744"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1744"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1777" mass="191151" checksum="91A98B331820E477" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5C9</accession>
    <name>Q1D5C9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3964"/>
    <dbReference type="EnsemblBacteria" id="ABF86411">
        <property type="protein sequence ID" value="ABF86411"/>
        <property type="gene ID" value="MXAN_3964"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3964"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053050_0_0_7"/>
    <dbReference type="OMA" id="DMTALRC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="318" mass="33477" checksum="96385654F259A818" modified="2006-07-11" version="1">MKRLYINNWVTWTGTHQSRVPARRPLRGETLGVETWHGACLGASPRNPARGGVPMFPKSVRALFLVGALSACGTEAPPDVPNADGQEPLQSQESNVIVGSVNWVSATTLSGTQRTRSRAVGYLSIPAVGSRCTAWLVSRDVIITNNHCVGSSSEASGARVSFNYEDGVSSTARVWYNCGTLIRTWAGDDMTALRCTATNGQLPGDVYGWLTVASANAATNASIYVLHQNCDYYTTSGCTPTKKSSPGVVRNANYSTTDLSYDADTLGGSSGSPVLSSSSHQVVGLHHIGLGGNSQGRGTANTGVKATRVKARLAEIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L2</accession>
    <name>Q1D5L2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Pyruvate carboxylase</fullName>
            <ecNumber evidence="2 6">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pyc</name>
        <name evidence="14" type="ORF">MXAN_3881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3881"/>
    <dbReference type="EnsemblBacteria" id="ABF86450">
        <property type="protein sequence ID" value="ABF86450"/>
        <property type="gene ID" value="MXAN_3881"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3881"/>
    <dbReference type="eggNOG" id="COG1038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_1_7"/>
    <dbReference type="OMA" id="YAIQSRV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="5"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="125"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="13">
        <location>
            <begin position="539"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="1089"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="9">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF86450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127088" checksum="3E9656D5078457B4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z0</accession>
    <name>Q1D5Z0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, classes I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553764.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3751"/>
    <dbReference type="EnsemblBacteria" id="ABF86399">
        <property type="protein sequence ID" value="ABF86399"/>
        <property type="gene ID" value="MXAN_3751"/>
    </dbReference>
    <dbReference type="GeneID" id="41361084"/>
    <dbReference type="KEGG" id="mxa:MXAN_3751"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_7"/>
    <dbReference type="OMA" id="ARFRHFS"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="43094" checksum="72B244587D896F26" modified="2006-07-11" version="1">MSRPVAAQRVTRFATTVFSEFSALAARHGAVNLGQGFPDFDGPAAIKEAAQRAIRDGGNQYAMGAGARELRVAIAEHSARFYGQTVDPDTMVTVTSGATEAILDTLLGLVDPGDEVVAFEPFYDSYDANITFVGATARFVPLRPPDADHAQWWFDRDEVRAAFSPRTRLLILNTPHNPTGKVFTRDELTFLGELCAEFDVKVLSDEVYEHLVFEPARHLRPATLPGLAERTVTVSSGGKTFSLTGWKVGWVIAPPPLRDAVQRAHQFVTFATAAPLQAAMAEALRLPDAYFTELTASYAAKRERLLTGLREAGLTAFAPEGSYFILADITRQGFADDVAFCRHLVSKVGVAAIPPSVFYGPAHRHLGQGLARFAFCKTDAVLDEAVRRLRAGLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6C1</accession>
    <name>Q1D6C1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposition helper protein, IS21 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553634.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3614"/>
    <dbReference type="EnsemblBacteria" id="ABF87177">
        <property type="protein sequence ID" value="ABF87177"/>
        <property type="gene ID" value="MXAN_3614"/>
    </dbReference>
    <dbReference type="GeneID" id="41360955"/>
    <dbReference type="KEGG" id="mxa:MXAN_3614"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_1_1_7"/>
    <dbReference type="OMA" id="HVIKIKG"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="28379" checksum="6E26DC231BB94639" modified="2006-07-11" version="1">MSPLKERLNTLGLHHTSAALDDLIALATKRRWGPTELLEAITEEETKDRARRSVERRLSRSKLGALRTMADFDWGWPKRIDRTAVEGALALDFMARPANVVLVAPQGLGKTMIAQNIAYNAVQAGHPVLFTTASQLLLDLGSQDSARALDRRLKHYCTQAGLLVIDEIGYLSYDARNADLLFQVVSRRYEKKPIVLTTNLPFSEWTTIFPNAACAIALIDRVIHHASIISIEGDSYRRRMAEESRAERKARKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6C2</accession>
    <name>Q1D6C2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS21 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553633.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3613"/>
    <dbReference type="EnsemblBacteria" id="ABF86187">
        <property type="protein sequence ID" value="ABF86187"/>
        <property type="gene ID" value="MXAN_3613"/>
    </dbReference>
    <dbReference type="GeneID" id="41360954"/>
    <dbReference type="KEGG" id="mxa:MXAN_3613"/>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020626_1_1_7"/>
    <dbReference type="OMA" id="AHYRFEP"/>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="114"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="55487" checksum="A76B6E625E4FD1C3" modified="2006-07-11" version="1">MIGLEVRARIRQLHYAEGWPVGTIATQLGLHHDTVEAALEDAPVASADRSTAKPTVLGPYTDFIDVTLKAHPRLRATRLFHMVKARGYLGGYEQVKRYVRRVRPGPQAEAFLRRNTLPGEEAQVDWGSFGKVRVGRATRTLSCFVLVLGHSRAMYARFFLGQTMECFLQGHVQAFEALGGVPRNLLYDNLKSVVLQRAGDVIHFHPRILEAAGHYHFVPKPCAPYRGNEKGKVERTIRYLRDSFFSARTFHSLDDVNRQLQRWVEEVAHQRRVPGDASGRTVAQALEAERSLLLPLPAHPLPTDVVRPAASGKTPYVRFDGNDYSIPEGLVRRPLTLVASSTTVRLLDGAVEAASHVRSWDKGAVVEDASHLAALARRKAHAHELRGRDLLRARCPHAEQLLQALTSRGDNLGNHTVKLLALADRYGSAETDAAIAETLARGALGPAAVAHVLDQRSRKRGAPPPLPLVLPDDPRVREQRVPQHSLNPYDALLGRDTEQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6F0</accession>
    <name>Q1D6F0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553609.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3583"/>
    <dbReference type="EnsemblBacteria" id="ABF87900">
        <property type="protein sequence ID" value="ABF87900"/>
        <property type="gene ID" value="MXAN_3583"/>
    </dbReference>
    <dbReference type="GeneID" id="41360929"/>
    <dbReference type="KEGG" id="mxa:MXAN_3583"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410878_0_0_7"/>
    <dbReference type="OMA" id="HWNLRDE"/>
    <dbReference type="OrthoDB" id="99866at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="736" mass="81749" checksum="4DDFEA1DD0D8C34E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P8</accession>
    <name>Q1D6P8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytidine monophosphate-N-acetylneuraminic acid hydroxylase</fullName>
            <ecNumber evidence="3">1.14.18.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CMP-N-acetylneuraminate monooxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">CMP-Neu5Ac hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">CMP-NeuAc hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_3480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O</text>
            <dbReference type="Rhea" id="RHEA:16145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:58376"/>
            <dbReference type="EC" id="1.14.18.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553511.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3480"/>
    <dbReference type="EnsemblBacteria" id="ABF88933">
        <property type="protein sequence ID" value="ABF88933"/>
        <property type="gene ID" value="MXAN_3480"/>
    </dbReference>
    <dbReference type="GeneID" id="41360827"/>
    <dbReference type="KEGG" id="mxa:MXAN_3480"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525630_0_0_7"/>
    <dbReference type="OMA" id="DGWEIQR"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030338">
        <property type="term" value="F:CMP-N-acetylneuraminate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027033">
        <property type="entry name" value="Cnh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46522">
        <property type="entry name" value="PTHR46522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="12">
        <location>
            <begin position="455"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF88933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="535" mass="61419" checksum="E5EA1AB4E5FD3086" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6W9</accession>
    <name>PIMT_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="1">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcm</name>
        <name type="ordered locus">MXAN_3407</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553440.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6W9"/>
    <dbReference type="SMR" id="Q1D6W9"/>
    <dbReference type="STRING" id="246197.MXAN_3407"/>
    <dbReference type="PRIDE" id="Q1D6W9"/>
    <dbReference type="EnsemblBacteria" id="ABF91639">
        <property type="protein sequence ID" value="ABF91639"/>
        <property type="gene ID" value="MXAN_3407"/>
    </dbReference>
    <dbReference type="GeneID" id="41360754"/>
    <dbReference type="KEGG" id="mxa:MXAN_3407"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_7"/>
    <dbReference type="OMA" id="DGNKGWE"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000351882" description="Protein-L-isoaspartate O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <sequence length="212" mass="22929" checksum="0E09DC1AFE7F75EB" modified="2006-07-11" version="1">MGDWGRADYLSRHGIKDARVLEAIARLNRADFVPEDLREEASADSPLPIGHGQTISQPYVVALMTEALQLQGDERVLEIGTGSGYQTALLSLLCREVYSVEIVPELAQSAREVLGRQGFENVSFREGDGSLGWPDQAPFDAILAAAAPPDVPLQLLSQLKPGGRMIIPVGPRGGTQQLLRIQRALRPGEVPQVESLLSVRFVPMTGQPLSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X3</accession>
    <name>Q1D6X3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-O-methylguanine DNA methyltransferase, DNA-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553436.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3403"/>
    <dbReference type="EnsemblBacteria" id="ABF86567">
        <property type="protein sequence ID" value="ABF86567"/>
        <property type="gene ID" value="MXAN_3403"/>
    </dbReference>
    <dbReference type="GeneID" id="41360750"/>
    <dbReference type="KEGG" id="mxa:MXAN_3403"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_7"/>
    <dbReference type="OMA" id="PRHSRHV"/>
    <dbReference type="OrthoDB" id="1928537at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14714" checksum="4AA3558286E77208" modified="2006-07-11" version="1">MSTPPRDERDYFERIYTVTTQVPPGQVATYGDIAVIVGDGCDARVVGHALGALGARADSVPWQRVINRTGGISTSGYGQREALEAEGVTFDERDHVRMASHHWTGPSETWARAHGFQPLPPREVKTPDAQLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z5</accession>
    <name>Q1D6Z5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3381"/>
    <dbReference type="EnsemblBacteria" id="ABF86740">
        <property type="protein sequence ID" value="ABF86740"/>
        <property type="gene ID" value="MXAN_3381"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3381"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_132_0_7"/>
    <dbReference type="OMA" id="DVIRKWW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="205"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="530" mass="59350" checksum="B26576EFDF9C8479" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7C9</accession>
    <name>Q1D7C9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553290.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3245"/>
    <dbReference type="EnsemblBacteria" id="ABF91574">
        <property type="protein sequence ID" value="ABF91574"/>
        <property type="gene ID" value="MXAN_3245"/>
    </dbReference>
    <dbReference type="GeneID" id="41360598"/>
    <dbReference type="KEGG" id="mxa:MXAN_3245"/>
    <dbReference type="HOGENOM" id="CLU_2058851_0_0_7"/>
    <dbReference type="OrthoDB" id="610969at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13209" checksum="5ED0CCC0F386EE92" modified="2006-07-11" version="1">MLVIRDVQLAALAEPRLGALRAWLHPHLRKHFGERLLETDDAALKDFIDASVARAMEHGVRSSQGIVRFAHLRVLFGEGFEALPWAAETLSRTDIPTPESKIEILYGNARRALTAKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7X0</accession>
    <name>Q1D7X0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TonB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553100.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3044"/>
    <dbReference type="EnsemblBacteria" id="ABF89805">
        <property type="protein sequence ID" value="ABF89805"/>
        <property type="gene ID" value="MXAN_3044"/>
    </dbReference>
    <dbReference type="GeneID" id="41360406"/>
    <dbReference type="KEGG" id="mxa:MXAN_3044"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701393_0_0_7"/>
    <dbReference type="OMA" id="VGMHWNP"/>
    <dbReference type="OrthoDB" id="654325at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="415" mass="45385" checksum="C353150150ECF3A9" modified="2006-07-11" version="1">MSTGSPTNWRRRRRQGSSAGRFAAAIALALLLHAVYVGTLLLTSSFQGDGKARKPVTRPTSVAVRPLTADQWAQNRGKASPQTKSQASERPKAQDKKPEEKKPDETPKGQVVDVAPGNDEVDPNAKYLAESNNRVNKETRAREQTPFYRNAMPQRTAPQNQEGQNTDAQTPPRMAGNNGMGNDDRPVSQGGQKPAFEIPDARKKNEVAMKTDPTSPGPGMTVNNQNESDEVVGNSKRLNIQPGTGGEEAGSTGRAGAPGLASLTPSRAVMDKVLGAAPNDHLQDAEEGDGTLLNTREWKYASFFNRVKQSVGMHWNPNEQLRRRDPTGGIYTGRDRYTLLQITLDERGQVTDIQVEKSSGLDFLDFEAVSSFKRAQPFPNPPPGLLSDDAKVKFQFGFFMEMGGGPKMRLFRQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D865</accession>
    <name>Q1D865_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553005.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2948"/>
    <dbReference type="EnsemblBacteria" id="ABF92926">
        <property type="protein sequence ID" value="ABF92926"/>
        <property type="gene ID" value="MXAN_2948"/>
    </dbReference>
    <dbReference type="GeneID" id="41360311"/>
    <dbReference type="KEGG" id="mxa:MXAN_2948"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_3_7"/>
    <dbReference type="OMA" id="CALLSCW"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="30753" checksum="1B8EF2BFE432C084" modified="2006-07-11" version="1">METTLAEPSKWEQFHLAFDLFRDPLLCALIAGGVLGFLSVYVVLRRMVFVSAAVAQSAGLGVALAFYAAIHLGTHVEPVLGATTLALLATMLLMTEPAKLRLTRESLLGLAYALAGGAAVLVGDRIAQEAHDIQSILFGTAVLVTPEQLYTVAIAGGAIMFIHLWWYRGITFASFDRTGALVQGLPVRLLDGVLMVSIGVMVGVCARALGALPVFAFSTLSAIAALMLELRLPWTFFVATLFGAIAGVGGYLFAFFYDFPVGGSQTVFAAAMVAVATVLRMLVHAVQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D899</accession>
    <name>Q1D899_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein AsgB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asgB</name>
        <name evidence="3" type="ORF">MXAN_2913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002635080.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2913"/>
    <dbReference type="EnsemblBacteria" id="ABF91698">
        <property type="protein sequence ID" value="ABF91698"/>
        <property type="gene ID" value="MXAN_2913"/>
    </dbReference>
    <dbReference type="GeneID" id="41360281"/>
    <dbReference type="KEGG" id="mxa:MXAN_2913"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123184_0_0_7"/>
    <dbReference type="OMA" id="PDREVWE"/>
    <dbReference type="OrthoDB" id="1352033at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="2">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="18776" checksum="9987BCFD51F3930F" modified="2006-07-11" version="1">MSEVKQLQEEGGDQESDQAQERRRSKTMSRKEMARDLRRRRLTGQVDPEEADLLKQMDDTRPRTRADCINGPRPCNFVSCKHNLYLDVNPETGSIKLNFPDKEIWELEHTCALDVAEKGGITLEEVGEIMNLTRERIRQVETRGLMKLREATEAEPPVSARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G9</accession>
    <name>Q1D8G9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">alsS</name>
        <name evidence="6" type="ORF">MXAN_2843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552904.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2843"/>
    <dbReference type="EnsemblBacteria" id="ABF89407">
        <property type="protein sequence ID" value="ABF89407"/>
        <property type="gene ID" value="MXAN_2843"/>
    </dbReference>
    <dbReference type="GeneID" id="41360214"/>
    <dbReference type="KEGG" id="mxa:MXAN_2843"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_2_7"/>
    <dbReference type="OMA" id="DIGSHYI"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="186"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="378"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="58828" checksum="54B2882660A96686" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D927</accession>
    <name>Q1D927_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, CarD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="2">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e108946" last="e108946">
            <title>Structural insights into RNA polymerase recognition and essential function of Myxococcus xanthus CdnL.</title>
            <authorList>
                <person name="Gallego-Garcia A."/>
                <person name="Mirassou Y."/>
                <person name="Garcia-Moreno D."/>
                <person name="Elias-Arnanz M."/>
                <person name="Jimenez M.A."/>
                <person name="Padmanabhan S."/>
            </authorList>
            <dbReference type="PubMed" id="25272012"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0108946"/>
        </citation>
        <scope>STRUCTURE BY NMR</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552697.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="2LT3">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=56-164"/>
    </dbReference>
    <dbReference type="PDB" id="2LT4">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-68"/>
    </dbReference>
    <dbReference type="PDB" id="2LWJ">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-164"/>
    </dbReference>
    <dbReference type="PDBsum" id="2LT3"/>
    <dbReference type="PDBsum" id="2LT4"/>
    <dbReference type="PDBsum" id="2LWJ"/>
    <dbReference type="SMR" id="Q1D927"/>
    <dbReference type="STRING" id="246197.MXAN_2627"/>
    <dbReference type="EnsemblBacteria" id="ABF89955">
        <property type="protein sequence ID" value="ABF89955"/>
        <property type="gene ID" value="MXAN_2627"/>
    </dbReference>
    <dbReference type="GeneID" id="41360004"/>
    <dbReference type="KEGG" id="mxa:MXAN_2627"/>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048259_1_1_7"/>
    <dbReference type="OMA" id="DMKVMIP"/>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2LT3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2LT4"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2LWJ"/>
        </source>
    </evidence>
    <sequence length="164" mass="18719" checksum="CF11CEB8B135C892" modified="2006-07-11" version="1">MQTSFKTGDKAVYPGQGVGEVMGIEHTEVAGQRQSFYVLRILENGMRIMIPINKVGSVGLREIISEEDVKQVYSILKEKDISVDSTTWNRRYREYMEKIKTGSVFEIAEVLRDLYLLKGDKDLSFGERKMLDTARSLLIKELSLAKDCSEDEIESDLKKIFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D928</accession>
    <name>Q1D928_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552696.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2626"/>
    <dbReference type="EnsemblBacteria" id="ABF87010">
        <property type="protein sequence ID" value="ABF87010"/>
        <property type="gene ID" value="MXAN_2626"/>
    </dbReference>
    <dbReference type="GeneID" id="41360003"/>
    <dbReference type="KEGG" id="mxa:MXAN_2626"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_2_1_7"/>
    <dbReference type="OMA" id="ARYNPWR"/>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B6</accession>
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        <submittedName>
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    </gene>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="184" mass="20033" checksum="7E86D859E2469FFA" modified="2006-07-11" version="1">MPHPPFVEVRGPMKMFVRTALMMSAALLLGGCEVASEIGKPCALVRKATPEESAANNNSATMPILEREIAAQQDFISFGSVNCEDLICVRDQDYPRALNEDGSLNENAPAMGYCSKPCVEGGSSCEVTDTDDVNPDLPRRMSCRPMLLDQDTLDALRSADEAFYRRTFGENNSPFFCAGALIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M4</accession>
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        <submittedName>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
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    <dbReference type="STRING" id="246197.MXAN_2429"/>
    <dbReference type="EnsemblBacteria" id="ABF89391">
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        <property type="gene ID" value="MXAN_2429"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2429"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387167_0_0_7"/>
    <dbReference type="OMA" id="SFRDLYG"/>
    <dbReference type="OrthoDB" id="371311at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="42"/>
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    </feature>
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            <end position="694"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="702" mass="77261" checksum="FB9D8DFFD524F637" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9S8</accession>
    <name>Q1D9S8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2375"/>
    <dbReference type="EnsemblBacteria" id="ABF92217">
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        <property type="gene ID" value="MXAN_2375"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2375"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_1_1_7"/>
    <dbReference type="OMA" id="MWDCHIH"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188041" evidence="1">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="81"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="429" mass="45785" checksum="3E523C049D47D201" modified="2006-07-11" version="1">MRAFLFVSLFATTVATAAEPTHTAPPASYLLRPDRVFEGVTSKPHTGWVVLVTGDRIAAAGPEAKVKVPQGTTSVDLSGTTLLPGLIEGHSHLLLHPYNEASWNDQVLKESLALRVARATNHARATLAAGFTTARDLGTEGAADADVGLKQAIHQGIIPGPRLLVATRAIVATGSYGPKGFASEWHVPQGAEEADGVETLTRVVRAQIGQGADWVKVYGDYRWGPNHEARPTFSLEELKRIVDTARSSGRPVSVHATTPEGIRRAVLAGAESIEHGDEGTAEVFRLMAQRGVYLCPTLAASEAMFEHRGYKRGVDPEPTHLQQKRATFRAALSAGVPMCAGGDSGVFPHGENARELELMVAYGMTPAQALQAATSNNAAMLHREDQLGQVKAGLLADLVAVEGDPTKDITTLRKVRWVMKGGTVAVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z9</accession>
    <name>Q1D9Z9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552379.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2304"/>
    <dbReference type="EnsemblBacteria" id="ABF92999">
        <property type="protein sequence ID" value="ABF92999"/>
        <property type="gene ID" value="MXAN_2304"/>
    </dbReference>
    <dbReference type="GeneID" id="41359691"/>
    <dbReference type="KEGG" id="mxa:MXAN_2304"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_7"/>
    <dbReference type="OMA" id="SDQRHPY"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="51096" checksum="07844904045A58C2" modified="2006-07-11" version="1">MSIHPAGASTAAPLPPLSPGAPLIGHLRALRKDPLHFLQAQAREYGDVVRLPMGPADLVLVAHPDGVRHVLQDHARNYSKQSRGFRVLQELLGHGLLTSDGDHWLRQRRLAQPAFHRQRVAGFTRTMVDAAADLAATMEARADTGAAFNVAEDFTRLTLRIASSTLFGADVSSATHDIATVMSRLQVFVYKRLTQPVPLSLRLPLPAHRQFERDVGSLNRVVHGIIAKRRRESGEHHDLLQMMMEAHDDDTGERMSDSQLRDEVLTLLLAGHETTASALAWTIMLLSQHPGVRRDMESELARELGGRNPTHEDLPRLELTHRVVDESLRLYPPAWALSRIATKEDLVGGFRIPKGAHLLIAPWVTHRHPSIWDNPEGFDPDRFLPEREQARPRFAWFPFGGGPRQCIGNQFALMELVLVLATLLQRVRLNLTPGQVIHPTPAITLRPRPGVWVTASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA79</accession>
    <name>Q1DA79_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552299.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2223"/>
    <dbReference type="EnsemblBacteria" id="ABF88574">
        <property type="protein sequence ID" value="ABF88574"/>
        <property type="gene ID" value="MXAN_2223"/>
    </dbReference>
    <dbReference type="GeneID" id="41359610"/>
    <dbReference type="KEGG" id="mxa:MXAN_2223"/>
    <dbReference type="eggNOG" id="COG3653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016107_1_0_7"/>
    <dbReference type="OMA" id="GCPEVID"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="580" mass="64749" checksum="492A471849707F94" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAM5</accession>
    <name>Q1DAM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552153.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2069"/>
    <dbReference type="EnsemblBacteria" id="ABF90763">
        <property type="protein sequence ID" value="ABF90763"/>
        <property type="gene ID" value="MXAN_2069"/>
    </dbReference>
    <dbReference type="GeneID" id="41359477"/>
    <dbReference type="KEGG" id="mxa:MXAN_2069"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336309_0_0_7"/>
    <dbReference type="OMA" id="EEMYVAP"/>
    <dbReference type="OrthoDB" id="1526710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="22260" checksum="1A81AD4AA77EA0CA" modified="2006-07-11" version="1">MFVGVARLTLQIPDSGSLKSKRQVLRRVTDRLKARFNVAVAEVEDQDLWQKASLALAVVGNERRHVDEQLEKIIHSVEEMYVAPLLSRETEILGFGDQLFASGQAASRGSFSAQAVDEDVEELDLSPEQAAAHSEAAIARFLRGERGSLAEAEGLGEWESRHEGGMDGGTSRPSPSSGGRMTFDEARARARSLRNPRDWEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB33</accession>
    <name>Q1DB33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551996.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1895"/>
    <dbReference type="EnsemblBacteria" id="ABF88640">
        <property type="protein sequence ID" value="ABF88640"/>
        <property type="gene ID" value="MXAN_1895"/>
    </dbReference>
    <dbReference type="GeneID" id="41359310"/>
    <dbReference type="KEGG" id="mxa:MXAN_1895"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_0_7"/>
    <dbReference type="OMA" id="MHIPPDA"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="13697" checksum="FEA5CDBED4846F4B" modified="2006-07-11" version="1">MHIPPDALTFAPPKRRARPLPVILGEALREARLRAGLQQTEVATLINISRNAYSRLERGLMLPSVPTLYRLCTAVCTTPNELLGFSYSLPPGTSAIAKDALRRRVRQLNGRQALALIQLLSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBC0</accession>
    <name>Q1DBC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1807"/>
    <dbReference type="EnsemblBacteria" id="ABF88350">
        <property type="protein sequence ID" value="ABF88350"/>
        <property type="gene ID" value="MXAN_1807"/>
    </dbReference>
    <dbReference type="GeneID" id="41364696"/>
    <dbReference type="KEGG" id="mxa:MXAN_1807"/>
    <dbReference type="eggNOG" id="COG2452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2509208_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="85" mass="9556" checksum="9491CC51EF22171A" modified="2006-07-11" version="1">MRAATQLQLPEARGSVDAVAARIGVPKVPLFRWFDAKRLPAHRGGKLWKFKLSEVDDWVRAGGASKARTRAMPVRRTTTTRKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBC9</accession>
    <name>Q1DBC9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551903.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90457">
        <property type="protein sequence ID" value="ABF90457"/>
        <property type="gene ID" value="MXAN_1796"/>
    </dbReference>
    <dbReference type="GeneID" id="41359217"/>
    <dbReference type="KEGG" id="mxa:MXAN_1796"/>
    <dbReference type="HOGENOM" id="CLU_2118425_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="114" mass="11493" checksum="F267488E15AA0C9C" modified="2006-07-11" version="1">MRATMVEPINDAAGKTLVAAGSEVDGTMTELQPSTRADKPAAIRVNFDRLTTRTGMEPIAAEVVEAKPEVNQSHGRAEMGAAIGGLGGLAAGAILGHPFTGAVIGGVLGAGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBP2</accession>
    <name>Q1DBP2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1574075">
            <id>Q1DBP2</id>
        </interactant>
        <interactant intactId="EBI-1574045">
            <id>Q1CWA4</id>
            <label>MXAN_7206</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551790.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1DBP2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1679"/>
    <dbReference type="EnsemblBacteria" id="ABF87908">
        <property type="protein sequence ID" value="ABF87908"/>
        <property type="gene ID" value="MXAN_1679"/>
    </dbReference>
    <dbReference type="GeneID" id="41359118"/>
    <dbReference type="KEGG" id="mxa:MXAN_1679"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_37_7"/>
    <dbReference type="OMA" id="NETYNAG"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="199"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="41732" checksum="A7E372E8E5B4C95A" modified="2006-07-11" version="1">MGMSAALALVLMGTFFTLFSYDLEDAIFARLVATAADGRRDDTGAIPLGMTAYVGHEGLPSWLGDALPLDTPRGEYEVFAQGRGHFHVAVRPDASAGTTRYVVLDTTALTSTTRHLRQTSGLLLASALLALLGAAGLSLVVARRLSRPLEQLVARVQSDTLAPEVDVGVTEVRALAEALRVRDARIQELLERERAFNRDASHELRTPLAVAQGAVEILELDPPADTETFGRLRQAIHHMGLLTEGILWLARSGRSDESCGLVSISREMVALYGKHRPHGDVALVIEAKEEVLAPLPGSVARVMLGNLIKNALAYTHQGRIVIHIAPEGWSISDTGVGFGQVEPGHSGFGIGLSLVERLARRFNCDVAFSAVEPHGTRVRLTWPSVEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBY7</accession>
    <name>Q1DBY7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1584"/>
    <dbReference type="EnsemblBacteria" id="ABF91856">
        <property type="protein sequence ID" value="ABF91856"/>
        <property type="gene ID" value="MXAN_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1584"/>
    <dbReference type="HOGENOM" id="CLU_2602347_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="79" mass="8759" checksum="C7A2BA632DB15884" modified="2006-07-11" version="1">MREAPRMEPTIPHRDADGFGALFSEFTEQARRRVRAELREEGQQAPGGTGRSNQEASDTSSVTASHIETTRLEDSGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC12</accession>
    <name>Q1DC12_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551670.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1559"/>
    <dbReference type="EnsemblBacteria" id="ABF91587">
        <property type="protein sequence ID" value="ABF91587"/>
        <property type="gene ID" value="MXAN_1559"/>
    </dbReference>
    <dbReference type="GeneID" id="41359004"/>
    <dbReference type="KEGG" id="mxa:MXAN_1559"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068443_2_0_7"/>
    <dbReference type="OMA" id="GVNTVWF"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="PTHR13610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188368" description="Methyltranfer_dom domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="5">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="21273" checksum="DA4C8140BB148014" modified="2006-07-11" version="1">MKRMMVVFAFTAAMAANAASVSTAQQTVTVQVRGPAGSSIQSPEVPFVPTPEGAVDGMLALAGVKPGDTVYDLGSGDGRIVISAVQKHGAKHAVGVDINPERIAEANQNASQAGVKNKVEFRQGDLFDADIRDASVVTLYLLPSVNERLKSKLLSELKPGTRIVSHSFDMGDWAPTKTVQSEGRTLYLWVVPERGTGGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC57</accession>
    <name>Q1DC57_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sigma70_r4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551625.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1514"/>
    <dbReference type="EnsemblBacteria" id="ABF89007">
        <property type="protein sequence ID" value="ABF89007"/>
        <property type="gene ID" value="MXAN_1514"/>
    </dbReference>
    <dbReference type="GeneID" id="41358960"/>
    <dbReference type="KEGG" id="mxa:MXAN_1514"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287717_0_0_7"/>
    <dbReference type="OMA" id="QILCEVR"/>
    <dbReference type="OrthoDB" id="1259217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="2">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="27909" checksum="D1873485BC1CB709" modified="2006-07-11" version="1">MPTPPHILPAPIDMSAPDTRSGDTGEQACSPDASERREDGMSAAVQGLRMTTLRLSKEADEPAEATAPGEDEALLARRALTGERAAWDALVARHHRRVVVSLLARGVRVDRAQELAQETWARLIQQQQRGLLTELRLPNLALTQAAFLAADDARRARRESIAGAVDELPERHHPVDPSVSAERRLLTEEQLSRAHAALAQVSPSARNVFLLACDGQELPHAAIASRVGLSVQRVRQILCEVRKKLRTALEEETHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCP5</accession>
    <name>HMUV_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemin import ATP-binding protein HmuV</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hmuV</name>
        <name type="ordered locus">MXAN_1321</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551438.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCP5"/>
    <dbReference type="SMR" id="Q1DCP5"/>
    <dbReference type="STRING" id="246197.MXAN_1321"/>
    <dbReference type="PRIDE" id="Q1DCP5"/>
    <dbReference type="EnsemblBacteria" id="ABF88932">
        <property type="protein sequence ID" value="ABF88932"/>
        <property type="gene ID" value="MXAN_1321"/>
    </dbReference>
    <dbReference type="GeneID" id="41358767"/>
    <dbReference type="KEGG" id="mxa:MXAN_1321"/>
    <dbReference type="eggNOG" id="COG4559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_7"/>
    <dbReference type="OMA" id="YPRITWI"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51261">
        <property type="entry name" value="HMUV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000269602" description="Hemin import ATP-binding protein HmuV">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01718"/>
        </source>
    </evidence>
    <sequence length="267" mass="28239" checksum="507643AA5734464B" modified="2006-07-11" version="1">MSLEVRGIEVWRGRGRTLGPMDLTLEPGEVLAVVGPNGAGKSTLLSAMSGELRCSTGEVLLDGTPLLQWKPRERAMRLGVLPQESSLGFGFTALEVALLGRSPHSSRAEGSADLAAAVAALDATDTRHLASRSYLTLSGGERQRVQLSRVLAQLSEPLASGHRYLLLDEPTASLDLAHQHLVLEAAARFAQAGGAVLAVLHDLNLAARYAHRMAVLAEGRVVELGAPAQVLSQELVARVFGLRVQVVEWPGSPGPLVIPEGRAPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS2</accession>
    <name>Q1DCS2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CsgA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csgA</name>
        <name evidence="2" type="ORF">MXAN_1294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551411.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DCS2"/>
    <dbReference type="STRING" id="246197.MXAN_1294"/>
    <dbReference type="EnsemblBacteria" id="ABF92128">
        <property type="protein sequence ID" value="ABF92128"/>
        <property type="gene ID" value="MXAN_1294"/>
    </dbReference>
    <dbReference type="GeneID" id="41358740"/>
    <dbReference type="KEGG" id="mxa:MXAN_1294"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_7"/>
    <dbReference type="OMA" id="GIGLEYC"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="229" mass="24628" checksum="4B8E6A635AC16C5F" modified="2006-07-11" version="1">MRYVITGASRGIGFEFVQQLLLRGDTVEAGVRSPEGARRLEPLKQKAGNRLRIHALDVGDDDSVRAFATNVCTGPVDVLINNAGVSGLWCALGDVDYADMARTFTINALGPLRVTSAMLPGLRQGALRRVAHVTSRMGSLAANTDGGAYAYRMSKAALNMAVRSMSTDLRPEGFVTVLLHPGWVQTDMGGPDATLPAPDSVRGMLRVIDGLNPEHSGRFFDYQGTEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW0</accession>
    <name>Q1DCW0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">MXAN_1256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551373.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1256"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="EnsemblBacteria" id="ABF86350">
        <property type="protein sequence ID" value="ABF86350"/>
        <property type="gene ID" value="MXAN_1256"/>
    </dbReference>
    <dbReference type="GeneID" id="41358701"/>
    <dbReference type="KEGG" id="mxa:MXAN_1256"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_7"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="67"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="351"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="48345" checksum="179F4CAFDDEF854D" modified="2006-07-11" version="1">MAKAKTHYTCQACGYKTAKWLGKCPDCGAWSSLLEETDPKADERRPAWGASGGSARPMLLKEVSGETETRRRTGIAEFDRVLGGGVVSGSIVLLGGDPGIGKSTLLLAALDRLARHGPVLYVSGEESLRQTKMRAERLRVEGEAIHLFAETDAERVLTATEALKPQALVVDSIQTMYLPELGNAPGSITQVREVAGRLMAYAKRTGVPTFLVGHVTKEGSIAGPRVLEHMVDTVLYFEGERGHPFRILRAHKNRFGSTNEIGVFEMKGAGLVEVSDPSALFLSERPVGKSGSVVTSTLNGTRPLLVEVQALVAPTGYGTARRTAIGVDGNRVALLAAVLEKKEEIPLVGCDLFVNVAGGMQLTEPACDLAVCAALVSSLQNRPLDPKTLVLGEVGLAGEVRAVGQVEPRLAEAAKMGFQRVVMPAGSARRLEDAGPKMKIVGVETLGDALVAMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD14</accession>
    <name>Q1DD14_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1200"/>
    <dbReference type="EnsemblBacteria" id="ABF91504">
        <property type="protein sequence ID" value="ABF91504"/>
        <property type="gene ID" value="MXAN_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1200"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707216_0_0_7"/>
    <dbReference type="OMA" id="AGTGWHT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="44738" checksum="B33F997BBB08A03F" modified="2006-07-11" version="1">MSTGGAKWIGRWDGGRVRLTRGRSVWVIERRVNGIVRAITLDVASERDARAELVLFERDPGAYKTKKQVAAEAAASVAQAEKKGVALDEETFEAFLRNVKAEGLTDRYRRYILAPYLTAWGVALEKRPLRDVSLTELHVMLDKWPTARTPRIIALKAFTAWLRERDMLRLAEDPTAELKVPPSKAEKSIRQKGYSMAAVEQAYAEANSQRLRDTLCLRAKTGMHGTEIDRVARGDAILKDVSDPCGIKGTITFRQLKADMTHTISLDAQAFAAVERLQAFGKGLEDSGIVQSLRRIAERLKLTCVDEEQRKKIVPLHPSQLRHSFSTWARKYGELVRPTGKGLPIEEVSAVMGHTSVKTTKKFYLTEEVPPMIRLPLQLVHQEDPSTDRITSRKAASID</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD76</accession>
    <name>Q1DD76_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551257.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1137"/>
    <dbReference type="EnsemblBacteria" id="ABF92225">
        <property type="protein sequence ID" value="ABF92225"/>
        <property type="gene ID" value="MXAN_1137"/>
    </dbReference>
    <dbReference type="GeneID" id="41358588"/>
    <dbReference type="KEGG" id="mxa:MXAN_1137"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047522_1_0_7"/>
    <dbReference type="OMA" id="ARYSDCD"/>
    <dbReference type="OrthoDB" id="1622875at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="38091" checksum="562003670CDBC896" modified="2006-07-11" version="1">METPPPSRPPTDVRSQLVGPMLAYLRATGRDPSPLVERFGLPANASALPEVTLPLATLHAFLDAAEALSGDAFLGLHVAQRVPRGNYGLVEYIARASPTVRDTFRALARYMALLEPAWRASFQDAPDGSGTFVYGIPGEPLAYGRHASEFGLALFVHVGRQLTEHPWNPRHVSFAHPAPADLRPLEQHFGVTPAFDAGRNALTLDAATLALRVVDADPVLLSVLERAAGTPAAEPPSVPRTPPFLQQVRDALRASLRNGAPQMGDVARQLHVSPRTLQRRLAEHATSFQDEVDAVRRELAFDYLRDAHLGVSEVAFLLGYSELSTFDRAFKRWTGMTPRVWRERPEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH4</accession>
    <name>Q1DDH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551159.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1038"/>
    <dbReference type="EnsemblBacteria" id="ABF90314">
        <property type="protein sequence ID" value="ABF90314"/>
        <property type="gene ID" value="MXAN_1038"/>
    </dbReference>
    <dbReference type="GeneID" id="41358492"/>
    <dbReference type="KEGG" id="mxa:MXAN_1038"/>
    <dbReference type="HOGENOM" id="CLU_1487531_0_0_7"/>
    <dbReference type="OMA" id="GQAIPEM"/>
    <dbReference type="OrthoDB" id="1942449at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021302">
        <property type="entry name" value="DUF2780_VcgC/VcgE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11075">
        <property type="entry name" value="DUF2780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="181" mass="17439" checksum="33556890D7F8BD85" modified="2006-07-11" version="1">MDLIGQLSQQLGVNGTQAQGLAGSLLKLVQGTVQEKLGPDAANQMGQAIPEMESWQQAPSTTSAPQTAPDAGGGLMGALGGLMSGQEGSTGGMLSALGGVAGQAGDVAAVVSLLGRFNIDASKASLVAPLLLNFLKSRLDPALVGRILSVVPLLAGAGGGGNTPGGGGLGGMLGGLLGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDR8</accession>
    <name>Q1DDR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551065.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0944"/>
    <dbReference type="EnsemblBacteria" id="ABF88705">
        <property type="protein sequence ID" value="ABF88705"/>
        <property type="gene ID" value="MXAN_0944"/>
    </dbReference>
    <dbReference type="GeneID" id="41358403"/>
    <dbReference type="KEGG" id="mxa:MXAN_0944"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801447_0_0_7"/>
    <dbReference type="OMA" id="QVFAQWH"/>
    <dbReference type="OrthoDB" id="1584052at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188524" evidence="3">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="38489" checksum="86611A64EADED274" modified="2006-07-11" version="1">MTQLLRLAALVSLIPSFASADVVWKGDFETGNTSQWTRSQSVSNSRLQVVTDVVREGRYALKATVRQGDDPINASGNRNELLYISQEKPDSTWYYKWSTLFPTNYPLNDSWQVFAQWHQEGCCGSPPLEFYVRGEAMHMRVGGVKGKVLWTAPLKRGDWSDFVLQVKWSPNAKTGFVQLWHNNEVVVPKTYVATQFGKEMNYLKLGLYRDDTIRPEASVYHDGFTMASTLEEVMPPPTPEPTPEPPAPEPEPTTPAPEQPGEDAPSEEPPDEPIVRTPDTQPRTRWGVTPPEDILSGESPLGADGARGCNASGGGTAGVPITAAVGLLSFAALFARRRKPAQARAHAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDZ2</accession>
    <name>Q1DDZ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidyl-peptidase</fullName>
            <ecNumber evidence="2">3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the removal of dipeptides from the N-terminus of oligopeptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S46 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550991.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0870"/>
    <dbReference type="EnsemblBacteria" id="ABF88550">
        <property type="protein sequence ID" value="ABF88550"/>
        <property type="gene ID" value="MXAN_0870"/>
    </dbReference>
    <dbReference type="GeneID" id="41358329"/>
    <dbReference type="KEGG" id="mxa:MXAN_0870"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013776_0_0_7"/>
    <dbReference type="OMA" id="CPKVEAN"/>
    <dbReference type="OrthoDB" id="99817at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070009">
        <property type="term" value="F:serine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019500">
        <property type="entry name" value="Pep_S46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38469">
        <property type="entry name" value="PTHR38469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10459">
        <property type="entry name" value="Peptidase_S46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023153896" description="Dipeptidyl-peptidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="692" mass="75816" checksum="236274CF05CA6C98" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE74</accession>
    <name>Q1DE74_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma-32 factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550909.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0785"/>
    <dbReference type="EnsemblBacteria" id="ABF91761">
        <property type="protein sequence ID" value="ABF91761"/>
        <property type="gene ID" value="MXAN_0785"/>
    </dbReference>
    <dbReference type="GeneID" id="41358252"/>
    <dbReference type="KEGG" id="mxa:MXAN_0785"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_7"/>
    <dbReference type="OMA" id="ARWGEGH"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="30796" checksum="3CA19C8661CF7C7C" modified="2006-07-11" version="1">MGAPNRRRSMEAINLNVSFESPELVVPAEVAEARVREHLKLVRRLAWKYRWTGLSMEELVAEGNVGLMEAAGRFEERGVPFAAYASQWIRARIRAYVGRNWSMAGGRAPWVVFQLRRERSRLEARWGEGHPEVEKRLAEALGKREDEVALAMEALSRDVSLDAPVSPDSEATRLEGLMADADSQEDQVDRAKWARRLRASVDAAWPELDARERALVEERMLAEDGVSAELLARRFGVTAVRIRQIEQGLRVKLRHRLTAGLTSWDGEAMSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEC8</accession>
    <name>Q1DEC8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550855.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0729"/>
    <dbReference type="ESTHER" id="myxxa-q4vps9">
        <property type="family name" value="DLH-S"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89650">
        <property type="protein sequence ID" value="ABF89650"/>
        <property type="gene ID" value="MXAN_0729"/>
    </dbReference>
    <dbReference type="GeneID" id="41358200"/>
    <dbReference type="KEGG" id="mxa:MXAN_0729"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_7"/>
    <dbReference type="OMA" id="QMVDLAC"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="31137" checksum="50E26DC3A874E04A" modified="2006-07-11" version="1">MKPWHGFCNLPVRSACSTAATQSDKEEGLRMKKQGSRRSDEGSEKAVRGLVTQPQGTGGWTPPAADGEVRIPVEEGVELRGLLQVPPGATGVVVMVRGHGSSRRGATDQEVARLLQHEGLATLAVDLLTAAEEEACRERDLRFNLGLFGGRLAGVARWLRRAPRTSALRIGYFGAYTGAAAALAAAAMRPEAVDAVVCRGGRLAQPGAALARVRAPTLLIVGAEDTSAQEPHRRTYAALTTEKRLEVIPGATHRFEEPGTLTQMVDLACIWFLQHLGAPRWDSLPAPRAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEC9</accession>
    <name>Q1DEC9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0726"/>
    <dbReference type="EnsemblBacteria" id="ABF91864">
        <property type="protein sequence ID" value="ABF91864"/>
        <property type="gene ID" value="MXAN_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0726"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="MPTINGD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17786" checksum="34702DE1D1C5E0AF" modified="2006-07-11" version="1">MWGATGNDVWRILTPSGSTRSAIRTLKGEAMPETKIRVLIVDDDQDQLSLVERTLSAFGFDVRTHRSSLGVSNLVRTTQPDLVLLDVNIPALSGDKVLTLARGQAPKGTKFILYSASDESQLRALARASGADGYICKSVQGEELAQRLEALHLKPAASEAVQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE1</accession>
    <name>Q1DEE1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-glutamate methylesterase domain protein</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550842.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0714"/>
    <dbReference type="EnsemblBacteria" id="ABF90117">
        <property type="protein sequence ID" value="ABF90117"/>
        <property type="gene ID" value="MXAN_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="41358187"/>
    <dbReference type="KEGG" id="mxa:MXAN_0714"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_7"/>
    <dbReference type="OMA" id="IVQHRHK"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="18842" checksum="D4DB8CC4C175458E" modified="2006-07-11" version="1">MNPLGLLVVGAPRCAAADVESVLALLPPHLPVPVALALHRGPLDALAAPLGRRCALPVVEPDDKDPLLPGAVYLAPAGYHLLVDRGCVSLSVEPPEHGQRPGLDALFESAADSHGPRAAGLLFAGHEDGVAGLQVLHARGARVAVVSTLQTGGAGEEGAMAQLTLGSVGGWLARLAYVPRSKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ1</accession>
    <name>Q1DEJ1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550795.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0664"/>
    <dbReference type="EnsemblBacteria" id="ABF88934">
        <property type="protein sequence ID" value="ABF88934"/>
        <property type="gene ID" value="MXAN_0664"/>
    </dbReference>
    <dbReference type="GeneID" id="41358139"/>
    <dbReference type="KEGG" id="mxa:MXAN_0664"/>
    <dbReference type="eggNOG" id="ENOG502Z94I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194266_0_0_7"/>
    <dbReference type="OMA" id="VIAWMRH"/>
    <dbReference type="OrthoDB" id="1558143at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="26016" checksum="C75A5631273E32B5" modified="2006-07-11" version="1">MWPPPTSDFTMPESLTFAPTSDPRRVRAPDGRVLTVPDGWALLPPGDAGLTRRVKAAGPSWTVAEKVGRKLFSRGVWAPEAHILHARAALEAERATPAYEKKLAAGRERRAREQEAYEVDFANAVLRFLAFSPAWLPHAKRMAVLVAAHATPVGSGTVARTERIPLERRAEAAVIAWMRHQTTSYDDMRIARVKGARREVRRELADISRAVLDLHRRDVPHGPSACPLCTALSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF14</accession>
    <name>Q1DF14_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86623">
        <property type="protein sequence ID" value="ABF86623"/>
        <property type="gene ID" value="MXAN_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0489"/>
    <dbReference type="HOGENOM" id="CLU_3082153_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="52" mass="5564" checksum="6A15969E912FC820" modified="2006-07-11" version="1">MSGLSSLSDVVLLERMLAAARRGRVPEGERRAFGAEARGPLREDVRSGRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFB7</accession>
    <name>Q1DFB7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quaternary ammonium compound-resistance protein SugE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sugE</name>
        <name evidence="6" type="ORF">MXAN_0384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550520.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0384"/>
    <dbReference type="EnsemblBacteria" id="ABF91561">
        <property type="protein sequence ID" value="ABF91561"/>
        <property type="gene ID" value="MXAN_0384"/>
    </dbReference>
    <dbReference type="GeneID" id="41357880"/>
    <dbReference type="KEGG" id="mxa:MXAN_0384"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_1_2_7"/>
    <dbReference type="OMA" id="WPTIAFC"/>
    <dbReference type="OrthoDB" id="1990300at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="11514" checksum="89E76F221C1616C4" modified="2006-07-11" version="1">MSWLLVLVAGLLETCWAVGLKYTQGFTRPWPSLFVAVTLISSLALLSIAMRTLPAGTAYAVWVGIGALGAALVGIVLFREPATLGRFFFLGLMVVSVIGLKFTSGGDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG1</accession>
    <name>Q1DFG1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0338"/>
    <dbReference type="EnsemblBacteria" id="ABF89799">
        <property type="protein sequence ID" value="ABF89799"/>
        <property type="gene ID" value="MXAN_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0338"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_2_7"/>
    <dbReference type="OMA" id="DMRDWAQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="33934" checksum="997CCA53236414D7" modified="2006-07-11" version="1">MAETGNTRWGTARLDGGKVLRWSLLHVGALVGGTCFFSWSAVAVFAGMTAVTMCLGVSVGLHRGLIHRAFRASAPVERALALLGTLAGLGGPIAMSRMHDLRDFHQNQPEADCPPYFGYREGFTRAMAYALFHTWHPRSGAADVPAAPHVTQDVFFRGLERAGLWLQVPLALALYALGGAPWVAWGILVRLALTQDGFWCVHYVSHVEGEQPYELPGCAEQGRNAGWLALLSMGESWHNTHHVYPASAQMGLGWRQPDPGWWAVRGLAALRLVHDVKSLAHLPPRPGARTRRPEPHRTRRLCVLALRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFI2</accession>
    <name>Q1DFI2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550455.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0311"/>
    <dbReference type="EnsemblBacteria" id="ABF91188">
        <property type="protein sequence ID" value="ABF91188"/>
        <property type="gene ID" value="MXAN_0311"/>
    </dbReference>
    <dbReference type="GeneID" id="41357809"/>
    <dbReference type="KEGG" id="mxa:MXAN_0311"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_7"/>
    <dbReference type="OMA" id="PDVVLWD"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="21584" checksum="76212DCDDD84CBEB" modified="2006-07-11" version="1">MLAASTSPLRLFLVSEDPLARGALARALGDQTGVHFEVAAGTQVDLESQPGEPPDAVLWDTGLRPSNMEGPDLGAPVLALVVDEAAGEAALGAGARGLLFRDAEPSALVAALLSVARGLTVFDPALAELRATPRASLPAQATAPDALTPREREVLGLLAEGLSNKAIADRLDISEHTAKFHVNAVLAKLGVQRRTEAVVRAAKLGLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX3</accession>
    <name>Q1DFX3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmosensitive K+ channel His kinase sensor domain/universal stress domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550314.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0167"/>
    <dbReference type="EnsemblBacteria" id="ABF89157">
        <property type="protein sequence ID" value="ABF89157"/>
        <property type="gene ID" value="MXAN_0167"/>
    </dbReference>
    <dbReference type="GeneID" id="41357670"/>
    <dbReference type="KEGG" id="mxa:MXAN_0167"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_4_7"/>
    <dbReference type="OMA" id="LNVEREN"/>
    <dbReference type="OrthoDB" id="684949at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KdpD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="253"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="44024" checksum="4A18838C238DEC64" modified="2006-07-11" version="1">MTMTRRSRAEDFLELVERGRRGRLKLYIGFAAGVGKTYRMLEEAHALKRRGVDVVLGFVESHDRADTQALVEGLEVVPRKQYSYRDVTVEEMDLDAVLARKPQVAVVDELAHTNLPVCRHRKRYQDVQALLDAGINVIGAFNVQHLESLNDLVERATGVAVRETLPDSFLKAADQVVNLDLAVEDLHERLRTGKIYAKDKVPRALERFFTEENLATLRELALREVAESLDRATARPPPGEGDEGSQRSAAWGRVLVALSSYPRHAATLMRRGSRMAGRLNTDWFVVYVETPREAPHLIDAEAQRHLLTNIEKAKELGAEVVRLRARDPVEGILDFARSHGVGHIIVGRSHQPWWKQRLGRAVDMRLVREGRGFDIHVVAFEPREEGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL5</accession>
    <name>Q1CVL5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7453</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Myxococcus</taxon>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87746.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="494" mass="53395" checksum="3165B53508668486" modified="2006-07-11" version="1">MGLVRPLWNPEGGEADAPALSVPLKVAGTPGSWFDGAPRMASRPRGMPMRLSWMLLLLLIGPACSTVRVVRLDTGDVAPIVHTPRDAEGASSVELDDEVFEAAVVSLARDVRPSLHPLRDARHRFGVPDRSGVYVYERRGQRLIPVEERADGPRLLMAYADERLTRDYGQWCAQKRQPGDCLRLLDEGPLLASDGKYTLAMAIAMDSVWDETAEALRDMADPQAWMATVTASVSMYLLLWALPEPVSKGVAALVTATAIAYLGVDTVWLLLDGWIALVRQVDRATTFAQLSEAGEAYGEVLGENAARIFVMLATAAIGNTAGLAAKAPRLPGSSQAALNVEVQAGYRYAALGRVESVAMTADGFTVALAPHAVAMAAGGSSGAGRIQKHHIATNKNDVSAARGGPWTPEFRRIFKRAGMELKDPENIVQIQGHQGPHPQAYHELVFRRLNSATARCRSVEECRKVLTKALQQLAREAATQGTEINKLLTHGHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS7</accession>
    <name>Q1CVS7_MYXXD</name>
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    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
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    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_7389"/>
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    </dbReference>
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    <dbReference type="OMA" id="QNIMAHQ"/>
    <dbReference type="OrthoDB" id="1712822at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="142" mass="14601" checksum="ED71B7E2B33DC0BD" modified="2006-07-11" version="1">MGALKSVTNVISKVASTVSKIAGGIANIGGKAMEFLQKPLSSLVDPIAKFIGDKVGKLPLVGKFLGPTAENLVKQGAASFLGEGTLGSLGFLSKIAPKVQDITNIAQAVKGAADKVGAFAENPLGLQNFQNIIAQNHARFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV4</accession>
    <name>Q1CVV4_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">MXAN_7361</name>
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    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Durkin A.S."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
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    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187962" evidence="1">
        <location>
            <begin position="19"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="59804" checksum="2D5DD682AF2895DA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW22</accession>
    <name>Q1CW22_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7288</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
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                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DK1622</strain>
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        <property type="evidence" value="ECO:0007669"/>
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            <end position="92"/>
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        <location>
            <begin position="8"/>
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        <location>
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            <end position="977"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="991" mass="108509" checksum="1A5E57FBC752DA43" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD0</accession>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
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        <property type="protein sequence ID" value="ABF92328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="MXAN_7180"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
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    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="271"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="507" mass="54862" checksum="18779EC8B65453B7" modified="2006-07-11" version="1">MKVSSGLPRVSDGPCSARGGSMSLRSWLAATMGVLTLVTLAAATLLIVLTSVLDRSAATLGVAFGGIRVSEELEVGLLAHDRMVREGPVKVPRGPGGLSRFELEASLYRQMGELRRIASTAAERQRLDAVREDVDVYFSAQWDPVRAEQEAGPALDAALSGLEQVSSINVERARVARSEAERWNDMADSVGVVLCGLLLLGVLVVSVLLRRVALQPLRDISQSMRRFGAGCRRARAPEAGPTELRDMARTFNEMANSLAHQQEQQLAFLAGVAHELRNPLSALKLSTALSDRSRAQLTPERMDRTLSLVGRQVERLDRMVGDLLDATRIEAGRLELRPEVRDARELAREVVELYRSGDTGHGLRLSLPDVSVPVRADPARLEQVLHNLISNALKYSPAGSTVEVSVRREKDTAVLCVTDQGIGISEEEMRLLFAPFQRAGNARQRAPGVGLGLSVARRIVEGHGGSIDVTSQPGHGSVFCVRLAVATEAVRHAEEDAGLTSLEDTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG2</accession>
    <name>Q1CWG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557067.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7148"/>
    <dbReference type="EnsemblBacteria" id="ABF89596">
        <property type="protein sequence ID" value="ABF89596"/>
        <property type="gene ID" value="MXAN_7148"/>
    </dbReference>
    <dbReference type="GeneID" id="41364322"/>
    <dbReference type="KEGG" id="mxa:MXAN_7148"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_7"/>
    <dbReference type="OMA" id="VHDHERI"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="427"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="519" mass="56719" checksum="CE97EC65FA7ABE40" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWT7</accession>
    <name>Q1CWT7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF92561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92561">
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        <property type="gene ID" value="MXAN_7023"/>
    </dbReference>
    <dbReference type="GeneID" id="41364199"/>
    <dbReference type="KEGG" id="mxa:MXAN_7023"/>
    <dbReference type="eggNOG" id="COG4880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015706_3_0_7"/>
    <dbReference type="OMA" id="FQGAYVY"/>
    <dbReference type="OrthoDB" id="688616at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="730" mass="81128" checksum="88D1A501F7527136" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX42</accession>
    <name>Q1CX42_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556837.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6917"/>
    <dbReference type="EnsemblBacteria" id="ABF92175">
        <property type="protein sequence ID" value="ABF92175"/>
        <property type="gene ID" value="MXAN_6917"/>
    </dbReference>
    <dbReference type="GeneID" id="41364099"/>
    <dbReference type="KEGG" id="mxa:MXAN_6917"/>
    <dbReference type="HOGENOM" id="CLU_2509194_0_0_7"/>
    <dbReference type="OMA" id="HTTPALW"/>
    <dbReference type="OrthoDB" id="1884999at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9673" checksum="F8FB58AFF8461209" modified="2006-07-11" version="1">MMSGTLELFHRIADAPSAQARRYIVDYALEDRVRFRNVAFDEAEADWRKHGGHTTPALWDGTHLHQGAQAVMARLQAVVNLGRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX87</accession>
    <name>Q1CX87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556794.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6869"/>
    <dbReference type="EnsemblBacteria" id="ABF91699">
        <property type="protein sequence ID" value="ABF91699"/>
        <property type="gene ID" value="MXAN_6869"/>
    </dbReference>
    <dbReference type="GeneID" id="41364058"/>
    <dbReference type="KEGG" id="mxa:MXAN_6869"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_7"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="26781" checksum="F9E4787B44E7DAA1" modified="2006-07-11" version="1">MNVLITGATAGFGLAIARRFIQDGARVIASGRRTERLEALRAELGERVLPLTLDITDREAVERAIRSLPAEFAEVDVLVNNAGLALGLDLAQSARVEDWDTMVDTNVKGLLYCTHAVLPGMVARNRGHVVNMGSVAAEWPYPGGNVYGATKAFVHQFSLNLRADLHGTAVRVTDIEPGLVGGTEFSNVRFKGDDTRAASVYANTQALTPEDIADAVHWVATRPAHVNINVMSLMPVSQSFGPLPVKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXD7</accession>
    <name>Q1CXD7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6819"/>
    <dbReference type="EnsemblBacteria" id="ABF90697">
        <property type="protein sequence ID" value="ABF90697"/>
        <property type="gene ID" value="MXAN_6819"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6819"/>
    <dbReference type="HOGENOM" id="CLU_1169662_0_0_7"/>
    <dbReference type="OMA" id="YTHFVGA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="27677" checksum="28D604A274C7607F" modified="2006-07-11" version="1">MQHIRPGRQSARRKVSLTCGALPPSGARGLKPPSLAACALAVLLSPCLASANEDDDGGVRTNTARLLTTDAAEVIDAPVLGLQRTALPLFAGLAVDTSMYANALLAPNVGLRWAMAASPHRVVLGARYTHFVGASVYSDVVTSGADTPALQRFEPELSGPSFYGVYGLSLGPVLVQGEARYGLYTSDYLSFTGALAFNFAGHWSVVGEAGVRVKGGSTLRAAAGIRYGGEHFGLGVGATYVDMSDPALPGESLPVLPVVDLSWSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXF4</accession>
    <name>Q1CXF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, zinc-containing</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adh</name>
        <name evidence="4" type="ORF">MXAN_6802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556727.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6802"/>
    <dbReference type="EnsemblBacteria" id="ABF88165">
        <property type="protein sequence ID" value="ABF88165"/>
        <property type="gene ID" value="MXAN_6802"/>
    </dbReference>
    <dbReference type="GeneID" id="41363991"/>
    <dbReference type="KEGG" id="mxa:MXAN_6802"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_7"/>
    <dbReference type="OMA" id="CENCEKG"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="7"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="37317" checksum="4B07BF6CBF96DD06" modified="2006-07-11" version="1">MRANVFQAVNRFGIEEVERPRAGAGEAVIRMTMTTVCGTDLHIVRGEYPVRPGLVIGHEPVGVIEELGPGVTDYRPGQRVLVGAITPCGQCRACLSSHLSQCGHGAGYEALGGWRMGNTQDGAQAEYIRIPAAQANLAPIPDGLTDEQVILLSDIASTGFSGAEAGSVRIGDAVVVFAQGPIGLCASIGARLMGASLVVGVDGDEARMKMAQRMGVDVVLDHRQQDVVAEVKRLTGGGADVAIEALGTQQTFESALRCLRPAGTLSSLGVYSGKLQLPYDAFSAGLGDYRIVTTLCPGGKERMRRLMDLVHHKRVDLSPLITHRFKLADIQEAYALFGERRDGVFKVAIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXF7</accession>
    <name>Q1CXF7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sodium bile acid symporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556724.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="TCDB" id="2.A.28.1.10">
        <property type="family name" value="the bile acid:na(+) symporter (bass) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87662">
        <property type="protein sequence ID" value="ABF87662"/>
        <property type="gene ID" value="MXAN_6799"/>
    </dbReference>
    <dbReference type="GeneID" id="41363989"/>
    <dbReference type="KEGG" id="mxa:MXAN_6799"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071291_1_0_7"/>
    <dbReference type="OMA" id="GTAQRNF"/>
    <dbReference type="OrthoDB" id="1675031at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GeneID" id="41363903"/>
    <dbReference type="KEGG" id="mxa:MXAN_6710"/>
    <dbReference type="HOGENOM" id="CLU_1007702_0_0_7"/>
    <dbReference type="OMA" id="CPTKEDG"/>
    <dbReference type="OrthoDB" id="1200812at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="289" mass="31250" checksum="555E8D5C58E96907" modified="2006-07-11" version="1">MPMSLRPRPGRCRAPARWTRGAAGLLLTGLMGCQMKCSEPVPDAGHALASLQRESPCVQVWRAAQVDVAFKEEPEDAVQQRTDTRLERRFTVARQLRGAYRHQDRWASVLEYEAGPVRGGVSYSLQVPDVLSDLTGQVVEWTSHREPASCPTKEDGEVPVLLSGDTLRDAEGRLLLLTVPSAPTTIAGDVLLPPGLVPELSFQWEDAGCTLADGTHALDVQLRVTHANRSQGPGTTVTAEVGQPAPLTLDGVRYVVRVARATADMQGRCGQAVFTLMREGLLEQGQSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY74</accession>
    <name>Q1CY74_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmB</name>
        <name evidence="6" type="ORF">MXAN_6526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556457.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6526"/>
    <dbReference type="EnsemblBacteria" id="ABF91312">
        <property type="protein sequence ID" value="ABF91312"/>
        <property type="gene ID" value="MXAN_6526"/>
    </dbReference>
    <dbReference type="GeneID" id="41363734"/>
    <dbReference type="KEGG" id="mxa:MXAN_6526"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_3_1_7"/>
    <dbReference type="OMA" id="FEPNLHT"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="78" mass="9094" checksum="DCC6A32A52E09AF6" modified="2006-07-11" version="1">MSKVCQVTGKRPLVGNTVSHANNRHKRRSLPNLQWHRFWVPSMNRFVKLRVSTHGIRIINQRGIDRVVRELLAEGVKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY77</accession>
    <name>RL332_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L33 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmG2</name>
        <name type="ordered locus">MXAN_6523</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556454.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CY77"/>
    <dbReference type="SMR" id="Q1CY77"/>
    <dbReference type="STRING" id="246197.MXAN_6523"/>
    <dbReference type="EnsemblBacteria" id="ABF86627">
        <property type="protein sequence ID" value="ABF86627"/>
        <property type="gene ID" value="MXAN_6523"/>
    </dbReference>
    <dbReference type="GeneID" id="41363731"/>
    <dbReference type="KEGG" id="mxa:MXAN_6523"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_7"/>
    <dbReference type="OMA" id="GTGFYYT"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000356578" description="50S ribosomal protein L33 2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <sequence length="54" mass="6256" checksum="A6CCEBA5A44A5125" modified="2006-07-11" version="1">MPKGNRTIIHLVSSAGTGYVYTTTKNKRKSQEKLQLRKYDPRVRKHVLFVEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY95</accession>
    <name>Q1CY95_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556436.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87237">
        <property type="protein sequence ID" value="ABF87237"/>
        <property type="gene ID" value="MXAN_6505"/>
    </dbReference>
    <dbReference type="GeneID" id="41363713"/>
    <dbReference type="KEGG" id="mxa:MXAN_6505"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_13_2_7"/>
    <dbReference type="OMA" id="LQFFTPY"/>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="448"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="629" mass="65819" checksum="E0F92C39F82861F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI7</accession>
    <name>Q1CYI7_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6412"/>
    <dbReference type="EnsemblBacteria" id="ABF90796">
        <property type="protein sequence ID" value="ABF90796"/>
        <property type="gene ID" value="MXAN_6412"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6412"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914752_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="36124" checksum="0A956D99CF511EC5" modified="2006-07-11" version="1">MGAVPHRPGPGPLRHPERSAGARREVVGGWTMRRALLRGISAALMLVSLSAGGTQTPRPGDDWRAGLKTNISRARQENPATFIRFDTAAAQVDALDAKKRGTLAAVSPGLRALGPEALWPMVERLAFPPQETPRLPSRESARLAFKVGLVEATGALRDLRLAPLWKSLLESPDTQPQVLRAVAGALARLETLDAANTLIAASKQKDARGEAAMEALGLCRRLVATRALADALDARPEREVMRRLAKALGDAGSAWAWKTSGVKARSEEGAIRLVAAEALVRAYVDTDGDVRRAVSNALLRVDAPQTPTLIDAARLSAPPAQQAALDALAERLRHNPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ44</accession>
    <name>Q1CZ44_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556142.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6198"/>
    <dbReference type="EnsemblBacteria" id="ABF86510">
        <property type="protein sequence ID" value="ABF86510"/>
        <property type="gene ID" value="MXAN_6198"/>
    </dbReference>
    <dbReference type="GeneID" id="41363426"/>
    <dbReference type="KEGG" id="mxa:MXAN_6198"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639081_0_0_7"/>
    <dbReference type="OMA" id="LLFMTAQ"/>
    <dbReference type="OrthoDB" id="357090at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="320"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="471" mass="52858" checksum="6D5AC6D481FE39E6" modified="2006-07-11" version="1">MRRPAREGLGRPLHTKGGGHSVTLRDSPARPHWPCCAPRRPMKLTRLEVHHYRNVVPGTSLVFSPSYNLVLGENGTGRTTLLELISTVLGSDFSGRIHEPFALEYDLAFPGMKLHVFVRNEENAPAPDTEAPPRKGSALMPLRTPALDSSLHPRIEVDVQLHSPSARLVMRADAAGMDCKVDGEAVWSRSMHWSLLDRSVWTLLFMTAQYIDAGMKERLKELLRRTFLLAPQRFDEALGMFERIGAIRYAMEVRDGEVFPLGLMALPTWMPGWLREQMEQPAVTDVLELTHDAREGSFLAKFVALAGFEAGRFRVEVLEKRSFENGGRVGFGGFGFEFTRRDGRVLTHEALGFGQKRLLSLLYYLDVNEDFAIADELGNGLHPRWVEASMRELGARQVFLTSQNPLLFEHTLFPSAEALRASLLLCGNTREDGPERIAWKNPTHEVAGRLFDAHGLGAHPLAELLRQQGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ74</accession>
    <name>Q1CZ74_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556112.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6168"/>
    <dbReference type="CAZy" id="GH15">
        <property type="family name" value="Glycoside Hydrolase Family 15"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86686">
        <property type="protein sequence ID" value="ABF86686"/>
        <property type="gene ID" value="MXAN_6168"/>
    </dbReference>
    <dbReference type="GeneID" id="41363398"/>
    <dbReference type="KEGG" id="mxa:MXAN_6168"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_7"/>
    <dbReference type="OMA" id="RMRFSYG"/>
    <dbReference type="OrthoDB" id="318658at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="219"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="614" mass="68753" checksum="698097E05D8530F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ98</accession>
    <name>Q1CZ98_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxygen-dependent FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556088.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6144"/>
    <dbReference type="EnsemblBacteria" id="ABF90321">
        <property type="protein sequence ID" value="ABF90321"/>
        <property type="gene ID" value="MXAN_6144"/>
    </dbReference>
    <dbReference type="GeneID" id="41363374"/>
    <dbReference type="KEGG" id="mxa:MXAN_6144"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024955_1_1_7"/>
    <dbReference type="OMA" id="ITFAICR"/>
    <dbReference type="OrthoDB" id="330793at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019139">
        <property type="term" value="F:cytokinin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015345">
        <property type="entry name" value="Cytokinin_DH_FAD/cytokin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09265">
        <property type="entry name" value="Cytokin-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="482" mass="53316" checksum="EA1651B6A12486A3" modified="2006-07-11" version="1">MSSRTVSRRTLLQGALVAVAFNPMSRSWASTLEAGAVPLPPLDGELLMDTASRTAATEDFGHILHRTPWAVLVPGSVKDIVAMVRFARRQGVKIAAARGLGESHSTFGQSQVAAGIVIDMSTLSTVHEIGENSAWVDAGVRWHELLQASLPHGKSPPVLTDYIELSVGGTQSAGGIGGQAFRWGLQVDNVLEMDVVTGRGELVRCSRWRERPLFDAVRSGLGQFGIIVRARVRLVEVPPRARTYTALYNDLHRFMEDQRRLIEDGRFDYVEGSAVASNGGRAYQLEVVKYFTPGSEPNDARLLAGLGFQPGTLQVSDGSYFDFANRLAPLVELLKQLGVWGFPHPWLDMFVPARSAESFVQEVLSQTTEADMGQGPILLYPFRSSELTTPFLRTPNDRHVFLFSLLRTAIPPTPENVASLLRKNRAIFDRLTAIGGKMYPVDALPLSPADWRRHFHPGWERFEHAKRRYDPDHILTPGQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ7</accession>
    <name>Q1CZQ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555930.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5981"/>
    <dbReference type="EnsemblBacteria" id="ABF89876">
        <property type="protein sequence ID" value="ABF89876"/>
        <property type="gene ID" value="MXAN_5981"/>
    </dbReference>
    <dbReference type="GeneID" id="41363220"/>
    <dbReference type="KEGG" id="mxa:MXAN_5981"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042387_3_1_7"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="OrthoDB" id="1462689at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="PTHR12124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="3">
        <location>
            <begin position="218"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="3">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="43019" checksum="879D34D73CD829C9" modified="2006-07-11" version="1">MPTYPQGAVDVVDASGEESATRTLEAAREIAVDLEADSMHAFRARLCFLQLATDDQVFLLDTLQPGVVPGMLAPLMADPARTKFFHAAQGDLQFLAEVGVRVQGLFDTHRAATLLGWPKVGLADLARERLGVELPKEHQQSDFSIRPLPPGMREYIANDVRYLCELGRQVRDACREADILEEVLLDCVRLCDEAAARPDVGADFKPKLPRAGLNPTQMTLAHAIAHALHRKRLEWAEKDNVPMGRMLSNMALGDIAVKLPTNPKELARMAGVRGSFIRSHGEELLAVVRELLEKSRRGELAPEREPKGPKDTNKRKREEALKTFRVEKATERKVTPSVVLTNPLMDALASQPPKDVEALTQVPYLGEKRVRLYGPALVELLAAYPVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR1</accession>
    <name>Q1CZR1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5977"/>
    <dbReference type="EnsemblBacteria" id="ABF90350">
        <property type="protein sequence ID" value="ABF90350"/>
        <property type="gene ID" value="MXAN_5977"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5977"/>
    <dbReference type="eggNOG" id="COG3791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_4_7"/>
    <dbReference type="OMA" id="CHCGRIA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="3">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14542" checksum="324F3817B69C213B" modified="2006-07-11" version="1">MPLIPCALGQDARMSESKRYEGGCHCGLVRYDVSLDLSQPLVSCNCSICLKTGMLLGFAPAEQFNLQKGAEHITDYQFGKKSIHHLFCDTCGVRSFGKGTMPDGKEMRAINVRCLDGIELDGLPVMKVDGKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY0</accession>
    <name>Q1CZY0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator family protein MmrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mmrA</name>
        <name evidence="7" type="ORF">MXAN_5906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555857.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_5906"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        </location>
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    </feature>
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            <end position="186"/>
        </location>
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        <location>
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            <end position="237"/>
        </location>
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            <end position="266"/>
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        </location>
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            <end position="321"/>
        </location>
    </feature>
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            <begin position="342"/>
            <end position="361"/>
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    </feature>
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            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="44692" checksum="4EE76134270D7B54" modified="2006-07-11" version="1">MPNQRQVSERAVVALIGAVQFVNILDFVMVMPLGPDFAKELGIASSHIGIIGGAYTAAASVAGLAGGYFLDRFDRRKALAVSMLGLVVATAAGGFATGMSTLMLARVVAGIFGGPATSLSLSIIADLVPVERRGRALGAVMGAFSVASVAGVPMALKLAEFGGWRVPFFAVAAMGLLVVLGAIFYLPPVRGHLDAGPRKQAGVLELLANRDIQLSYVMTALVMMAGFVLIPNLSAYLQQNVGYPRDLLWLPYFIGGIASFATLRVAGPMVDRYGSFKVGTVGSALVLLSTYVGFVHLPRWMPVPVIFTLFMVAMGTRNVAYNTLTSRVPDTPVRARFMSLQSAVQHMAAAVGAFLSARLLTDLPDGTLGGIPRMAGVSMVLTLLLPALLWVVERRVHSREQARALAVAPSQGMAVPLSPGADSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D021</accession>
    <name>Q1D021_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5865</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88428">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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            <begin position="63"/>
            <end position="84"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="87" mass="9104" checksum="C012ADBC3FA7AC6E" modified="2006-07-11" version="1">MAKGGQTPPAPGSAEAHAAWARKEAGDVAGARRDAERILAGNPSAEDRAEAEELLRCTTTPRALYGFALLAATVFVLLLVLAIVRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_5678</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF90315.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="COG4929">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105410_0_0_7"/>
    <dbReference type="OMA" id="SIMQGDY"/>
    <dbReference type="OrthoDB" id="1812417at2"/>
    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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        <property type="entry name" value="GDYXXLXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14345">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="17988" checksum="3D02E63AF735CF21" modified="2006-07-11" version="1">MMVRTAVIFGGLAFALLVPAGLVVQKEHVLRSGTPVLLELAPVDPRSLIQGDYMVLDYAISRERDANPVTTAKDGNMVLRLDANGVGSFVRFDTPDTPLAPGELKLRYRLRKERFRLGAEAFFFQEGHADRYEGARYGELRVADSGSSVLVGLRDAQRQPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0S4</accession>
    <name>Q1D0S4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5610</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF89487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5610"/>
    <dbReference type="EnsemblBacteria" id="ABF89487">
        <property type="protein sequence ID" value="ABF89487"/>
        <property type="gene ID" value="MXAN_5610"/>
    </dbReference>
    <dbReference type="GeneID" id="41362856"/>
    <dbReference type="KEGG" id="mxa:MXAN_5610"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_2_7"/>
    <dbReference type="OMA" id="GPVPFKV"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="609"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="672" mass="71324" checksum="3ABBA7DE5E1B56E5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Y0</accession>
    <name>Q1D0Y0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5554"/>
    <dbReference type="EnsemblBacteria" id="ABF88035">
        <property type="protein sequence ID" value="ABF88035"/>
        <property type="gene ID" value="MXAN_5554"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5554"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088548_0_0_7"/>
    <dbReference type="OMA" id="YMPNMYE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="19648" checksum="64C13851BE98D04E" modified="2006-07-11" version="1">MVVLSLTVTGCEQDETRPNFEYAPDMVSSVPFDTFAANPVTVDGKTLLAPVKGTVPRGYQPLHLAAGAEEAARAGRELQNPYPASPEVLARGKVTFSRYCGPCHGPEGLGDGLVTARFPMPPSLLAERAKQLPDGQVFHIITHGQGLMPAHGSQVAPEDRWKIVHYVRTLQDPARTARKDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Z2</accession>
    <name>Q1D0Z2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome oxidase maturation protein, cbb3-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccoS</name>
        <name evidence="3" type="ORF">MXAN_5542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555496.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5542"/>
    <dbReference type="EnsemblBacteria" id="ABF92731">
        <property type="protein sequence ID" value="ABF92731"/>
        <property type="gene ID" value="MXAN_5542"/>
    </dbReference>
    <dbReference type="GeneID" id="41362790"/>
    <dbReference type="KEGG" id="mxa:MXAN_5542"/>
    <dbReference type="HOGENOM" id="CLU_2863103_0_0_7"/>
    <dbReference type="OMA" id="RDHEHAD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="63" mass="6954" checksum="02B4A148D95D8AE5" modified="2006-07-11" version="1">MNVLVLQVFVSLMLVASSVLLFVYSVRHRDHEHADRLSLFPLEDDSAAPAPRAPEPPPSASQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D150</accession>
    <name>Q1D150_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555438.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5480"/>
    <dbReference type="EnsemblBacteria" id="ABF87759">
        <property type="protein sequence ID" value="ABF87759"/>
        <property type="gene ID" value="MXAN_5480"/>
    </dbReference>
    <dbReference type="GeneID" id="41362735"/>
    <dbReference type="KEGG" id="mxa:MXAN_5480"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_7"/>
    <dbReference type="OrthoDB" id="1439189at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="34547" checksum="E8A11A3A89022159" modified="2006-07-11" version="1">MDFDGVRTFIAVADTGQFQEAASRLSLTQQAVSKRIAALEASLGARLFVRAPRGVQLTIDGQVFLPHARRLLEAAERAADSVRPGRRRLRVDVVKPNLGSARILRDFHSAHPEIEIDVVTHLFDAKTALAAVRTGTIDATFRAITRPAQQLTDGLVATRVLDDAVEFLTSDTHRLAAATSLTPAELAKHKVWMPFIVPGTEWAAYYDELAARFGLTIDTLGPDFGIDALLEVIAGSSSLATLVGEHIRLVWPAEYNLRRIPIRNPMLVYPHSLVWRCDNAHPALAKLRAYLDARKDRYRHPKAWSPPWTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D163</accession>
    <name>Q1D163_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555425.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5467"/>
    <dbReference type="EnsemblBacteria" id="ABF92891">
        <property type="protein sequence ID" value="ABF92891"/>
        <property type="gene ID" value="MXAN_5467"/>
    </dbReference>
    <dbReference type="GeneID" id="41362723"/>
    <dbReference type="KEGG" id="mxa:MXAN_5467"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042543_2_0_7"/>
    <dbReference type="OMA" id="NEVLWFM"/>
    <dbReference type="OrthoDB" id="900869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188108" evidence="2">
        <location>
            <begin position="32"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="48"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="339" mass="36440" checksum="65D9A5179E6BEFAF" modified="2006-07-11" version="1">MPMPPSLLRTRPLLVLIPLLLAAAPAPHAPAQPRLEDAVPDTFTGVERVVAVGDVHGDVDALKEVLRLAGLIDAKDRWIGGKTHLVQTGDVPDRGDQTRAAFDLLMRLEQEALAAGGRVHALLGNHEAMNMLGDLRYVNPGEMASFADQSPEQDSAGSPPGLNGHRVAYSLQGRYGQWLRKHAAVVRINDTLFVHGGVAPGVPGGNLAELNRWVRQDFFPDHPPGGARDAQGPLWFRGYALGEPRDAEPALDAVLKRYGARRMVMGHTTNRDGKVKVRFNGKALLIDTGLSTGYGRNLAALELRGGKVNALYREGPVTLDSVEPSAAPARPAGPKPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1D8</accession>
    <name>Q1D1D8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5388"/>
    <dbReference type="EnsemblBacteria" id="ABF87494">
        <property type="protein sequence ID" value="ABF87494"/>
        <property type="gene ID" value="MXAN_5388"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5388"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3155204_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="48" mass="5280" checksum="A494863042E4BCF3" modified="2006-07-11" version="1">MVDTVGKKVAFIKAAARAAERQLRVVSSRAYRLPFSGAERQVAVFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1G2</accession>
    <name>Q1D1G2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 5`-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555326.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5361"/>
    <dbReference type="EnsemblBacteria" id="ABF89116">
        <property type="protein sequence ID" value="ABF89116"/>
        <property type="gene ID" value="MXAN_5361"/>
    </dbReference>
    <dbReference type="GeneID" id="41362629"/>
    <dbReference type="KEGG" id="mxa:MXAN_5361"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_2_7"/>
    <dbReference type="OMA" id="QKAWTNV"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142716" evidence="2">
        <location>
            <begin position="28"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="4">
        <location>
            <begin position="43"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="5">
        <location>
            <begin position="323"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="536" mass="56683" checksum="E867A549AB899F95" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T3</accession>
    <name>Q1D1T3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555205.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87518">
        <property type="protein sequence ID" value="ABF87518"/>
        <property type="gene ID" value="MXAN_5238"/>
    </dbReference>
    <dbReference type="GeneID" id="41362518"/>
    <dbReference type="KEGG" id="mxa:MXAN_5238"/>
    <dbReference type="eggNOG" id="COG2320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086407_1_0_7"/>
    <dbReference type="OMA" id="HVFGPDC"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22672" checksum="F5E9D55904E7C80D" modified="2006-07-11" version="1">MPSMPRPEDIMRHYDADPGENPWVKGKPAPEKVAVAPYDAGWPTRYAELAVAIQGVMGASAMQVEHVGSTAVPGLSAKPIIDIDLIVADPTREDDYVPALESLGYDLIIREPSWHQHRCLRLAAPRVNLHVFGPDCPEVIRHLMFRDWLREHDDDRQRYAAVKYTSAEGMDDVMEYNRRKEPVIRDLYARIFRAAGWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E1</accession>
    <name>Q1D2E1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">MXAN_5027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5027"/>
    <dbReference type="EnsemblBacteria" id="ABF91746">
        <property type="protein sequence ID" value="ABF91746"/>
        <property type="gene ID" value="MXAN_5027"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5027"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_3_0_7"/>
    <dbReference type="OMA" id="REYMADS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="66"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF91746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="31893" checksum="1EE7986C9721593B" modified="2006-07-11" version="1">MGNTLKTTVLLAGLTALVLVIGDRLGGPQGLLFAGLFAVVMNFGSYWFSDRIALAIHGARPLPYEQAPWLHDMVARLASRAGMPKPKVYILPTAAPNAFATGRNPSHAAIAVTAGLMELLDRRELEGVLAHELGHVRNRDTLIGTVAATLAGIISYAAQMLFWFGGSMLSRGDNDERGGLGSAFANLGLLLVAPIAATLLQLAVSRSREYGADQTGAELAGDPDALANALLKLERSAEAIPYDKAPATSHLFIVNPLHRGGVMALFSTHPPIPERVRRLRELGARLGARTGGRGGWEYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L5</accession>
    <name>Q1D2L5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554930.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4952"/>
    <dbReference type="EnsemblBacteria" id="ABF89548">
        <property type="protein sequence ID" value="ABF89548"/>
        <property type="gene ID" value="MXAN_4952"/>
    </dbReference>
    <dbReference type="GeneID" id="41362237"/>
    <dbReference type="KEGG" id="mxa:MXAN_4952"/>
    <dbReference type="eggNOG" id="ENOG5032MPF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741520_0_0_7"/>
    <dbReference type="OMA" id="CAPFGAG"/>
    <dbReference type="OrthoDB" id="760741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="38456" checksum="C2F75F98250989F0" modified="2006-07-11" version="1">MRSTFHIALATLVACCAAGCGNLENDPFRVGTVHGQLTESDPAVAMVSLVGQPGVSSHVDADGRFTLEDVPTGMAELFIIATTEKAARVQVRVLGGQSVQVQPVAPTPASFLDLHVKTTNGFRLSAAEASVEGTPFQRLLLDAKGRLRVGPLPDGCYTVTVTALGFPATQVQDCAGPGEKKELKVDLVLDESLLGQGCQEIGCEEGLVCAPNKKCLECFGNSHCGEGLTCKGNRCEGPGPQCAPCTGDWQCAAGTHCEVLPEGSAACATRCGGDDDAPPSVQARPNDVGSAQCAPGFTCQSGRCLPDAANFAGCHALRRMDAPCTDDASCHELGLLEGRCVSGACTAPCATDLDCPGSRRCVDSSAGPICQAGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D359</accession>
    <name>CHEB1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 1</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB1</name>
        <name type="ordered locus">MXAN_4752</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554739.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D359"/>
    <dbReference type="SMR" id="Q1D359"/>
    <dbReference type="IntAct" id="Q1D359">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4752"/>
    <dbReference type="EnsemblBacteria" id="ABF87312">
        <property type="protein sequence ID" value="ABF87312"/>
        <property type="gene ID" value="MXAN_4752"/>
    </dbReference>
    <dbReference type="GeneID" id="41362051"/>
    <dbReference type="KEGG" id="mxa:MXAN_4752"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="ISQHMPA"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264292" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="345" mass="36756" checksum="7F8C2E0E34F72F77" modified="2006-07-11" version="1">MSSKGVISVLVIDDSAHNRRTLSTMLESEPDVRVVDRAADGEEGLKKVVDLKPDVVTLDLEMPKLGGYTFLRLLMRTAPTPVIVISSYSHRSDVFKALELGAFDFIAKPQHPTFEAMEALRVELLEKVRAARHVRPGYRHAAPGARAMAVAGEPPLVVAVGASTGGPPAVQRVLEGLAVEPTPCVLVCQHMPPQFTRAFADRLDRIGPFSVTEARDGDLVQPGHVYIAPGGRHMVVAERGSRLELQTPPPTPVDKYAPCVDRLFVSMAQVLGAKALGVVLTGMGADGAEGARAVHRAGGEVWAQSEETSVVFGMPGEAIATGAVKRVIPLGDIGPALAALARRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3H5</accession>
    <name>Q1D3H5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554625.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4632"/>
    <dbReference type="EnsemblBacteria" id="ABF91392">
        <property type="protein sequence ID" value="ABF91392"/>
        <property type="gene ID" value="MXAN_4632"/>
    </dbReference>
    <dbReference type="GeneID" id="41361932"/>
    <dbReference type="KEGG" id="mxa:MXAN_4632"/>
    <dbReference type="eggNOG" id="ENOG5033MBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314759_0_0_7"/>
    <dbReference type="OMA" id="APRSIWR"/>
    <dbReference type="OrthoDB" id="1388431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188193" evidence="1">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="23642" checksum="2F738C5B62F064D3" modified="2006-07-11" version="1">MRRPFLTAALLGLLAGCVTTPPTAISDPPPSLPDEHAEHSYRKILARYTGQKEIYDGFDTRVFAGVTLQTLSFREARVHRQAAFQQLPTVKVEQMLAEEQAKAAQAHEFFLGVHFNDFVYADFDYKHSIWRLALVTPAGEVTPSRIRRLGRVNMQTRAYYPYTSIFWVGWEIQFPTQMSDGSPVIPPGTETVTFRMASSLGKADMQVSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M6</accession>
    <name>Q1D3M6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4579"/>
    <dbReference type="EnsemblBacteria" id="ABF92521">
        <property type="protein sequence ID" value="ABF92521"/>
        <property type="gene ID" value="MXAN_4579"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4579"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391157_0_0_7"/>
    <dbReference type="OMA" id="TMVAHIV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="487"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="712" mass="76940" checksum="21FBB460703E797D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3N0</accession>
    <name>Q1D3N0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4575"/>
    <dbReference type="EnsemblBacteria" id="ABF92765">
        <property type="protein sequence ID" value="ABF92765"/>
        <property type="gene ID" value="MXAN_4575"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4575"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093451_0_0_7"/>
    <dbReference type="OMA" id="NARMVTM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4142" evidence="1">
        <location>
            <begin position="109"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27555" checksum="75AD59BE9F115491" modified="2006-07-11" version="1">MATAACMASHNRTDFYELLRRHGCPPVHRSVVACTSRSFFPSMAVCFSTAQPSAEQQLRGTRVMRITRAMLGVAMVGTAVMFAGCGESSANENTLGPQQAAAGHPVTLTDGQILGVLLVANAGEVMLGQVGQAQATDPTARDFNARMVTMHSEVIQRLEQLATAQGIAPAESPVSQHLEQTVQKTVDMVSATQAPAFDVSVMDAQVAAHAGTALLGDSLLAMQVQNPALKDELMAIRKTVQAHLQEASNIQTTLYNAKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4A3</accession>
    <name>Q1D4A3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554348.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4347"/>
    <dbReference type="EnsemblBacteria" id="ABF91894">
        <property type="protein sequence ID" value="ABF91894"/>
        <property type="gene ID" value="MXAN_4347"/>
    </dbReference>
    <dbReference type="GeneID" id="41361659"/>
    <dbReference type="KEGG" id="mxa:MXAN_4347"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735344_0_0_7"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="376" mass="41986" checksum="987DA702786A5071" modified="2006-07-11" version="1">MRAELIERWKTADGQRRRSELLQMGLRGNWPEALSGFVATSELGDNPRDLRGIDLSGQDLASADLVRARLDGARLDGSGLEYAQLDLATLTGASLRFARLNHASLHACVARGTQWDDAQLEGTRLTASNLTGSSFRRARFRGAQLEQTILLNADLRNADLRDARLFLCDLEGALLTCVQWNPPRTYPVTSQHLAEIARRAGFPSFIEPFLLPGGIMDLLHMSNRQVLLHVEAAIEASTDVQSELRAILHEKNWRIVLMAAAGIVLAGADEATLAALWARLDEWSWVHPQLMVAAVLRDPSCDDRVRERLMHHELPRRNNIRESLEWAATVGRNVPGLREPHSGHPTCQAHRWLRQLQAFAPLKVQEQWLRGGSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4K6</accession>
    <name>Q1D4K6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4242"/>
    <dbReference type="EnsemblBacteria" id="ABF88864">
        <property type="protein sequence ID" value="ABF88864"/>
        <property type="gene ID" value="MXAN_4242"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4242"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_2_7"/>
    <dbReference type="OMA" id="WLACDKQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="143" mass="16142" checksum="5C9EF57CBA29DC28" modified="2006-07-11" version="1">MTLTTAVVILREMTTHALPQPTRAELAILRVLWKQGPSTVRQVHELMRGTQDKDTGYTTVLKLLQNMTEKGIVQRDESERTHVYEAAISETRTQRDLLRDLMDRAFGGSATSVVAQALSMKRASAEELAEIRRLLDAHEKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q7</accession>
    <name>Q1D4Q7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4191"/>
    <dbReference type="EnsemblBacteria" id="ABF86829">
        <property type="protein sequence ID" value="ABF86829"/>
        <property type="gene ID" value="MXAN_4191"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4191"/>
    <dbReference type="HOGENOM" id="CLU_3120174_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="50" mass="5551" checksum="AE69EA20217D0108" modified="2006-07-11" version="1">MAGNGCLRPFVCQASPRDCQRSRGVHELELEALELHRRQRMSGAATELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4T5</accession>
    <name>Q1D4T5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4163"/>
    <dbReference type="EnsemblBacteria" id="ABF90092">
        <property type="protein sequence ID" value="ABF90092"/>
        <property type="gene ID" value="MXAN_4163"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4163"/>
    <dbReference type="HOGENOM" id="CLU_3390403_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="32" mass="3559" checksum="A511E33029ED7F05" modified="2006-07-11" version="1">MNTSIVCAVTFAPIKEVPLLWRAGLTLRSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U9</accession>
    <name>Q1D4U9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator FrzS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">frzS</name>
        <name evidence="4" type="ORF">MXAN_4149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554152.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D4U9">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4149"/>
    <dbReference type="EnsemblBacteria" id="ABF88994">
        <property type="protein sequence ID" value="ABF88994"/>
        <property type="gene ID" value="MXAN_4149"/>
    </dbReference>
    <dbReference type="GeneID" id="41361468"/>
    <dbReference type="KEGG" id="mxa:MXAN_4149"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484698_0_0_7"/>
    <dbReference type="OMA" id="QWHKRLQ"/>
    <dbReference type="OrthoDB" id="487034at2"/>
    <dbReference type="EvolutionaryTrace" id="Q1D4U9"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="562" mass="60279" checksum="3B911603B957EA35" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D519</accession>
    <name>Q1D519_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4076</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria.</title>
            <authorList>
                <person name="Burgard C."/>
                <person name="Zaburannyi N."/>
                <person name="Nadmid S."/>
                <person name="Maier J."/>
                <person name="Jenke-Kodama H."/>
                <person name="Luxenburger E."/>
                <person name="Bernauer H.S."/>
                <person name="Wenzel S.C."/>
            </authorList>
            <dbReference type="PubMed" id="28128551"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX622595">
        <property type="protein sequence ID" value="APZ78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554083.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87342">
        <property type="protein sequence ID" value="ABF87342"/>
        <property type="gene ID" value="MXAN_4076"/>
    </dbReference>
    <dbReference type="GeneID" id="41361406"/>
    <dbReference type="KEGG" id="mxa:MXAN_4076"/>
    <dbReference type="HOGENOM" id="CLU_1516316_0_0_7"/>
    <dbReference type="OMA" id="ERYEPPD"/>
    <dbReference type="OrthoDB" id="1513230at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="APZ78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19674" checksum="A2333939E29D17F8" modified="2006-07-11" version="1">MPAEVTVQSTLFESLVRLAQPDAKLQAEFLAAGFDMDKPRATYPAAVFVGCQDATVRYRYKGMDRKSAYRTLGRELVRSYFDTLVGKVVGIALKVAGPERAMKRVSLSFSSVFSPVDIQVESLGPADWRVRFRGYPFPAEAAAGTCEGALRQAGATEPQANVERYEPPDGFDLRIRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D581</accession>
    <name>Q1D581_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554022.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4012"/>
    <dbReference type="EnsemblBacteria" id="ABF89190">
        <property type="protein sequence ID" value="ABF89190"/>
        <property type="gene ID" value="MXAN_4012"/>
    </dbReference>
    <dbReference type="GeneID" id="41361344"/>
    <dbReference type="KEGG" id="mxa:MXAN_4012"/>
    <dbReference type="HOGENOM" id="CLU_159961_1_0_7"/>
    <dbReference type="OMA" id="WLNQAAS"/>
    <dbReference type="OrthoDB" id="1736917at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="12583" checksum="7DABAA75E898F80A" modified="2006-07-11" version="1">MRIELKREGGPAYFPGLARPRVVDLTSLPPEQAEALRHSVQAARFFELPPVVGTLPPGAADARRFTVTVEEEGRRHTVQFIEPVEEPRLHDLLEQVTKAERAQRRGARPGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5M3</accession>
    <name>Q1D5M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553880.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3870"/>
    <dbReference type="EnsemblBacteria" id="ABF91636">
        <property type="protein sequence ID" value="ABF91636"/>
        <property type="gene ID" value="MXAN_3870"/>
    </dbReference>
    <dbReference type="GeneID" id="41361203"/>
    <dbReference type="KEGG" id="mxa:MXAN_3870"/>
    <dbReference type="eggNOG" id="ENOG50316SI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057424_0_0_7"/>
    <dbReference type="OMA" id="GVIHIPV"/>
    <dbReference type="OrthoDB" id="1970574at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="120" mass="13348" checksum="908B9512F3EA1B1E" modified="2006-07-11" version="1">MSEGFIPPPPEPRMLPTRHIAGVGCAWLFVVGIALLLIRWSVREYAPWAPAGFPPTLGVSEVADVNQRLFKREDAAPRLREAQRARLRGYGWVDRDAGVIHIPVEQALEQVLSTEEGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5N5</accession>
    <name>Q1D5N5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553868.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3856"/>
    <dbReference type="EnsemblBacteria" id="ABF86432">
        <property type="protein sequence ID" value="ABF86432"/>
        <property type="gene ID" value="MXAN_3856"/>
    </dbReference>
    <dbReference type="GeneID" id="41361189"/>
    <dbReference type="KEGG" id="mxa:MXAN_3856"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871056_0_0_7"/>
    <dbReference type="OMA" id="IEGWYWV"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="35068" checksum="FB86A90689BA264C" modified="2006-07-11" version="1">MVVKIASRLEPVRHPEPGRLRAWHLVCPSEALRPGQVMRWSTGTRELVLFRGRSGAVHALAAHCPHMGAHLGGGTVVGDSLRCPLHHWQFDGSGACPGKTAQRAFPVVERYGAILVFNGPVVLFPPPEVGSGALRWGTSARFAVHCDWLPVVANAFDLEHLRTVHHRELRDAPVVERPDPFTLRVRYTSRVTGSGLSDRVMKFLSGDRIGVTLTLHGGTLLSVESDLGRTRSALLAGLHQSEEGLFVRLAFAARRSRLPGVDWLALQVSRWLFTSFLRRDLSVLDGMRFNRAGAAADPVLRQVLDFTDSLPEAPDDDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z3</accession>
    <name>Q1D5Z3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553761.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3748"/>
    <dbReference type="EnsemblBacteria" id="ABF87747">
        <property type="protein sequence ID" value="ABF87747"/>
        <property type="gene ID" value="MXAN_3748"/>
    </dbReference>
    <dbReference type="GeneID" id="41361081"/>
    <dbReference type="KEGG" id="mxa:MXAN_3748"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_9_0_7"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="512" mass="56436" checksum="CC898964FD9F13A1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D4</accession>
    <name>Q1D6D4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3601"/>
    <dbReference type="EnsemblBacteria" id="ABF86834">
        <property type="protein sequence ID" value="ABF86834"/>
        <property type="gene ID" value="MXAN_3601"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3601"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037205_0_0_7"/>
    <dbReference type="OMA" id="QQGFYVY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="528" mass="59646" checksum="388CF09F26AF57F3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6I6</accession>
    <name>RLMN2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dual-specificity RNA methyltransferase RlmN 2</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN2</name>
        <name type="ordered locus">MXAN_3544</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553573.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6I6"/>
    <dbReference type="SMR" id="Q1D6I6"/>
    <dbReference type="STRING" id="246197.MXAN_3544"/>
    <dbReference type="EnsemblBacteria" id="ABF86078">
        <property type="protein sequence ID" value="ABF86078"/>
        <property type="gene ID" value="MXAN_3544"/>
    </dbReference>
    <dbReference type="GeneID" id="41360889"/>
    <dbReference type="KEGG" id="mxa:MXAN_3544"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_2_0_7"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000350273" description="Dual-specificity RNA methyltransferase RlmN 2">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="119"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="126"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="378" mass="42197" checksum="D947F5D86937EE89" modified="2006-07-11" version="1">MSETSATSLPVTEPLPAPAPAKLVDVASLSLEALSRFVTEELGERAFRAPQIYRWLHQRGATSFDEMTDLSKVLREKLRARAEIVPLVKDCELRSTDGTIKYRWKTRDGRYIESVYMPTEDRRTLCVSTQVGCAMACGFCMTGTMGLKRNLTPSEIVAQVHAVNREVRKNEGHETLRPLSNLVFMGMGEPLHNFENLKTALSILQSEDGPNFSHRHITVSTVGLVPMIERFGKETDVKLAISLNASTDEQRSKTMPVNRKWNIAALLDACRKFPLRQGRRITFEYVLIKGFNDADEDAHRLIELLKGIPVKVNLIPYNENPGLGFHTTGEERAEEFRAILADGHVAAYIRRNRGRDIAGACGQLANRGETQAGTDSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6J8</accession>
    <name>Q1D6J8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">o-succinylbenzoate synthase</fullName>
            <shortName evidence="4">OSB synthase</shortName>
            <shortName evidence="4">OSBS</shortName>
            <ecNumber evidence="4">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menC</name>
        <name evidence="6" type="ORF">MXAN_3531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553561.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3531"/>
    <dbReference type="EnsemblBacteria" id="ABF90722">
        <property type="protein sequence ID" value="ABF90722"/>
        <property type="gene ID" value="MXAN_3531"/>
    </dbReference>
    <dbReference type="GeneID" id="41360875"/>
    <dbReference type="KEGG" id="mxa:MXAN_3531"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_2_7"/>
    <dbReference type="OMA" id="NMAWSET"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="161"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="386" mass="40397" checksum="94A0501A498A2E33" modified="2006-07-11" version="1">MRIAQVSLIPLRLELRQPLKTSQGGHAVREGFLVRVVDEEGREGLGEAMPLPAFGTESLEDCGVTLNAWLSELKGQFLGDSVRAIEDTLSPFPPAVARGDGVRIRARQVTPAGAMPAAEHALELALLDLLAQRQGVPLCWLLAEEARTEVAVNALLGADTPEALAGEARQAVAEGFGTLKLKVAGRPLDADEARVKAVRDAVGPDVKLRLDANGGWSEPDAKRALDRLGWYGLELVEQPTPPEDLAALWRVQRRAPCTVAADESLASPDALRALLTVDPLLGGGPAVGAVVLKPMVLGGLLPCLVVAMRAARLGMQAYVTSSIDGVVARAGAAHLAAALPSGALASGLAIGRLLAKEPEDHPYHPQQGVIRLSSTPGLGLSSQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X5</accession>
    <name>Q1D6X5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553434.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3401"/>
    <dbReference type="EnsemblBacteria" id="ABF88885">
        <property type="protein sequence ID" value="ABF88885"/>
        <property type="gene ID" value="MXAN_3401"/>
    </dbReference>
    <dbReference type="GeneID" id="41360748"/>
    <dbReference type="KEGG" id="mxa:MXAN_3401"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375854_0_0_7"/>
    <dbReference type="OMA" id="HAEGALC"/>
    <dbReference type="OrthoDB" id="1706506at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="4">
        <location>
            <begin position="11"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="210"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="737" mass="79571" checksum="7B7753709241EFAB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z4</accession>
    <name>Q1D6Z4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553415.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3382"/>
    <dbReference type="EnsemblBacteria" id="ABF89428">
        <property type="protein sequence ID" value="ABF89428"/>
        <property type="gene ID" value="MXAN_3382"/>
    </dbReference>
    <dbReference type="GeneID" id="41360729"/>
    <dbReference type="KEGG" id="mxa:MXAN_3382"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_7"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="36056" checksum="1F8050A4225D36FB" modified="2006-07-11" version="1">MTTSPYTRGESGHGHEHDHGDGHGHGHHHHGHGHGHGHGPRRGGLAEERKKDKRRLIFALVLTATIALAEAVGGWLTNSLALMSDAGHMLTDVSALALSLVALWFAGKPADVKKTYGYYRMEILSALLNGVLLMGITGFILYEAWERVRSPAQVNIGPMAIVASVGLLANLGALGFLHRSHSMNVRGAFLHVLGDTLSSVGVLVGAGIMAYTGWYVVDPIISVVISIVIVIGAVRLVRDAVDVLMEAVPAHVDLAQIKELMLRAQGVTAVHDLHVWTISSGVYALSAHLVVQDPMVCNNDEILSAVKHDLFDRFGIDHTTIQIESETYSHLGEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D703</accession>
    <name>Q1D703_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553406.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3373"/>
    <dbReference type="EnsemblBacteria" id="ABF88255">
        <property type="protein sequence ID" value="ABF88255"/>
        <property type="gene ID" value="MXAN_3373"/>
    </dbReference>
    <dbReference type="GeneID" id="41360720"/>
    <dbReference type="KEGG" id="mxa:MXAN_3373"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_469820_0_0_7"/>
    <dbReference type="OMA" id="EFWIDEI"/>
    <dbReference type="OrthoDB" id="198638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188278" evidence="1">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="512" mass="57470" checksum="DB7F2DAE009CCDB6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D725</accession>
    <name>Q1D725_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553384.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D725"/>
    <dbReference type="STRING" id="246197.MXAN_3350"/>
    <dbReference type="EnsemblBacteria" id="ABF91158">
        <property type="protein sequence ID" value="ABF91158"/>
        <property type="gene ID" value="MXAN_3350"/>
    </dbReference>
    <dbReference type="GeneID" id="41360701"/>
    <dbReference type="KEGG" id="mxa:MXAN_3350"/>
    <dbReference type="eggNOG" id="ENOG5033E7Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2450419_0_0_7"/>
    <dbReference type="OMA" id="QHFNTRV"/>
    <dbReference type="OrthoDB" id="1945941at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="87" mass="10291" checksum="414A8BAE64AC89F4" modified="2006-07-11" version="1">MTDEEKVKAMRLARAIASDISLYNEQKIIKGIEQDNLFEVLKEELEEGRELYKSRVSQEIFTKMNFFERAINDIVLRSKAHVKSKIW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D758</accession>
    <name>RS5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">MXAN_3316</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553352.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D758"/>
    <dbReference type="SMR" id="Q1D758"/>
    <dbReference type="STRING" id="246197.MXAN_3316"/>
    <dbReference type="EnsemblBacteria" id="ABF89987">
        <property type="protein sequence ID" value="ABF89987"/>
        <property type="gene ID" value="MXAN_3316"/>
    </dbReference>
    <dbReference type="GeneID" id="41360669"/>
    <dbReference type="KEGG" id="mxa:MXAN_3316"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_7"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000323157" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="173" mass="18048" checksum="ECAE6BED794BC59A" modified="2006-07-11" version="1">MATPINPNDLDLTDRVVNINRVAKVVKGGRRFSFAALVVVGDGAGHVGVGLGKANEVPEAIRKGGENAKKNLFRVPLVGHTIPHEVLGHFGAGWVLLKPATQGTGVIAGGAVRAVLEAAGIRNILTKSQGSRNPHNVLKATVAGLKLLRSAEQVSRLRGKDVEPAKLAGEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H2</accession>
    <name>Q1D7H2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative RNA polymerase-binding protein DksA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553247.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3200"/>
    <dbReference type="EnsemblBacteria" id="ABF87439">
        <property type="protein sequence ID" value="ABF87439"/>
        <property type="gene ID" value="MXAN_3200"/>
    </dbReference>
    <dbReference type="GeneID" id="41360554"/>
    <dbReference type="KEGG" id="mxa:MXAN_3200"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_2_2_7"/>
    <dbReference type="OMA" id="KKGEEYM"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="120" mass="13987" checksum="3CA3B68801F86A1D" modified="2006-07-11" version="1">MNQKDLKRYKKMLEDSKASLLESAKKTLVEESSFDTDDLPDEIDLASSEYAQSMVFRLRDREKFLLQKIEKALVRIEDGTFGVCERCEEDISPKRLDARPVTTLCIRCKEEQEKKEKSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U8</accession>
    <name>Q1D7U8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ORF">MXAN_3072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553122.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3072"/>
    <dbReference type="EnsemblBacteria" id="ABF87176">
        <property type="protein sequence ID" value="ABF87176"/>
        <property type="gene ID" value="MXAN_3072"/>
    </dbReference>
    <dbReference type="GeneID" id="41360434"/>
    <dbReference type="KEGG" id="mxa:MXAN_3072"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_0_7"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="180" mass="20406" checksum="A60B9989E47448BB" modified="2006-07-11" version="1">MAMKWYVVHTYSNFENQAKKSLEEKVRLEGLQDQFGEILIPMEQVVEMVKGEKKTSRRKFFPGYIFVQMELNDRTLHLVKNTPKITGFPGTVQNQNPLPISDQEVARLTSQISEGTLKPKPKVQFDDGDTVRVIDGPFANFNGTVEEVNAEKGRVKVLVSIFGRATPVELDFMQVEKTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8B9</accession>
    <name>Q1D8B9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552954.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2893"/>
    <dbReference type="EnsemblBacteria" id="ABF88998">
        <property type="protein sequence ID" value="ABF88998"/>
        <property type="gene ID" value="MXAN_2893"/>
    </dbReference>
    <dbReference type="GeneID" id="41360262"/>
    <dbReference type="KEGG" id="mxa:MXAN_2893"/>
    <dbReference type="eggNOG" id="ENOG502ZBXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497629_0_0_7"/>
    <dbReference type="OMA" id="SELVYME"/>
    <dbReference type="OrthoDB" id="616189at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045477">
        <property type="entry name" value="ivWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045479">
        <property type="entry name" value="ivWA-helical_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19997">
        <property type="entry name" value="ivWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19996">
        <property type="entry name" value="ivWA-helical_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ivWA-helical_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ivWA" evidence="3">
        <location>
            <begin position="255"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="54480" checksum="60547B45EB9A5BA0" modified="2006-07-11" version="1">MSIEATSPQDTERWLCAGLCLIRHEDLTADALTSAVPWLLATLAESPALPPPAFIADLGRLVAGVPLAPSAPVPDTQPRLRAAVRAYDDHVLARLAAEPHLEAVSTALARLPETLRPRGVAFLVARVLSRMGFTAGSPVSPALARRVLERPPTELLQAGYTALRESGTSAALDRLTEGYEALASAARRAHALLGDAESFTLENLEHLQGKAQRMALEQAVEAAEALSRTLPPKLRARPVSTAPLPMALEDEAAFPQGGFSSVSNVGSLENLVTSELVYMEDEPNLDLFDVRYVEGELLYYTRDESISVRRRRVITFVLPPDLVDARVKDAGVRWQRVVVSMGLLLCLVRRLSLWLGSEELHFRAVFLHAHDGAVPLEAERGLCELLLREWRARGTAEVLTASTLDEVLTDAEARAKRARVDLVLLDASSQVERMSHPGASRVERHVLDLSGPSPRVRTIRDKREDLDSRKSEAPMGAALNNDPWEAWVGVTLELAQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G2</accession>
    <name>Q1D8G2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2850"/>
    <dbReference type="EnsemblBacteria" id="ABF87435">
        <property type="protein sequence ID" value="ABF87435"/>
        <property type="gene ID" value="MXAN_2850"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2850"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465323_0_0_7"/>
    <dbReference type="OMA" id="TLWHEVG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="PTHR23422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188363" evidence="3">
        <location>
            <begin position="35"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="617" mass="68355" checksum="CBE1C57F3784E132" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P1</accession>
    <name>Q1D8P1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2765"/>
    <dbReference type="EnsemblBacteria" id="ABF87755">
        <property type="protein sequence ID" value="ABF87755"/>
        <property type="gene ID" value="MXAN_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2765"/>
    <dbReference type="eggNOG" id="ENOG503303G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2035526_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13099" checksum="44D32B968F8E74D9" modified="2006-07-11" version="1">MTPPPQRHYPPTSTRSSSVADILERVLDKGIVITGDIKINLTNVELLTIQIRLIICSVERAQEMGLDWWTTNPNFSSRARQQLSAAQAPVAAPARGASAEPAAPAPRAAPKPRRAPKAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q0</accession>
    <name>Q1D8Q0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552823.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2756"/>
    <dbReference type="EnsemblBacteria" id="ABF92020">
        <property type="protein sequence ID" value="ABF92020"/>
        <property type="gene ID" value="MXAN_2756"/>
    </dbReference>
    <dbReference type="GeneID" id="41360133"/>
    <dbReference type="KEGG" id="mxa:MXAN_2756"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330757_0_0_7"/>
    <dbReference type="OMA" id="RVVMASQ"/>
    <dbReference type="OrthoDB" id="1506507at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188324" evidence="1">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="21427" checksum="01D937547261B705" modified="2006-07-11" version="1">MSRLPPLLLLCLLPFASAAAEADKPSRADLQRVLERHGRSVVHVKGPRNAGPGVFVGSAGQVLTSVTPVGASFTGLNAATVEHDGKTLPARVVMASQDLQVAVLAAPDGAYPAAPVKVLRDGDSLDGRWLVGVLPAKKGQPARPVPARARAAQPPFYDVPLALPAGSPVFDAEGRLVAVVVKKHRRGCRVLPLSAVKVELASVDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8V7</accession>
    <name>Q1D8V7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2699"/>
    <dbReference type="EnsemblBacteria" id="ABF89479">
        <property type="protein sequence ID" value="ABF89479"/>
        <property type="gene ID" value="MXAN_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2699"/>
    <dbReference type="eggNOG" id="COG1683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076318_1_1_7"/>
    <dbReference type="OMA" id="CPECAGG"/>
    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15275" checksum="D2B87FD9062481D7" modified="2006-07-11" version="1">MVLVSACLLGEACRYDGRSQRSERVLAALADKDVIPVCPEVASGLPVPRPPVDLRGGTGVDVWAGRAVAVERAAGIDRTEAFQQGARLALEAAQRFGATVALLKEKSPSCGSQRVYESGQLRAGEGITTALLRAKDITVLSDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D919</accession>
    <name>Q1D919_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552705.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2635"/>
    <dbReference type="EnsemblBacteria" id="ABF92782">
        <property type="protein sequence ID" value="ABF92782"/>
        <property type="gene ID" value="MXAN_2635"/>
    </dbReference>
    <dbReference type="GeneID" id="41360011"/>
    <dbReference type="KEGG" id="mxa:MXAN_2635"/>
    <dbReference type="HOGENOM" id="CLU_581023_0_0_7"/>
    <dbReference type="OMA" id="PRGFIQF"/>
    <dbReference type="OrthoDB" id="1520444at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="476" mass="47648" checksum="C7888D3C12BC5E43" modified="2006-07-11" version="1">MAGPFTTFVLSGLLAAAPGGFTFEGREASARTEQPDGFFIQGSLPFTDLAESGTGSASLTVEDRVSLPGATFGDKGTLEASFRLGATEYRVELMRPGFPPEQGKGGSGPPPRPPQHAIGGGVLLDVPLYGDSGLGWTAMTRTHAAVAVWGVGSVWRNGQLLTDTAFVHAAALAAGAYADDDTHRLLRQARYDDTELVVLVWNLPPQLEPRGFIQFVFEDVAIDVGGTAVRSRPFVENTGNPPLSWRSLTPVPPSAVVGAPVTASPPPAPSAIGGGGTAGALQDTGAVTRVTVPATAPGRLATAPVQTTTVPGVPVTPEIISGGLPVPMVTNTPVTYSGQLPVTPLDGTTVVAGTPGRGTTTGAFATPPTMSTFGSFTVQPLAPGSFGAFIGTGQSSAGIIATEPPLNSNPATPPPALLSTPAPLNAGTPTPLLGTPAPLNAAPALPLPATPSPVLGPATTAPAPAPAPAAPAAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D971</accession>
    <name>Q1D971_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VTC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552653.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2583"/>
    <dbReference type="EnsemblBacteria" id="ABF86381">
        <property type="protein sequence ID" value="ABF86381"/>
        <property type="gene ID" value="MXAN_2583"/>
    </dbReference>
    <dbReference type="GeneID" id="41359961"/>
    <dbReference type="KEGG" id="mxa:MXAN_2583"/>
    <dbReference type="HOGENOM" id="CLU_1238092_0_0_7"/>
    <dbReference type="OMA" id="CVKVRAK"/>
    <dbReference type="OrthoDB" id="997257at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="25997" checksum="DDB46A2B1B674DED" modified="2006-07-11" version="1">MLSFAEGEVTKLRREFKLVLEEKTAAALGTRLSLELEGHLPSPTRIVSVYFDRPGGPLAARALLTPEDCLKVRTKEYSPDRGADGEARVVLEVKRERHGLTQKRRVWVPRSDLGRVLRGGASLLPLIAGGSLSPVLAVTYTRHVYQSSQAWRATVDQDIRYHRIAPEQALSQLALSVERLEPAQWVEPRVVVEVKHLGHELPEWLASLNPGGAPAYSKFAEGMAKVHAFAADGVAGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA04</accession>
    <name>SYN_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="1">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnS</name>
        <name type="ordered locus">MXAN_2298</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552374.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DA04"/>
    <dbReference type="SMR" id="Q1DA04"/>
    <dbReference type="STRING" id="246197.MXAN_2298"/>
    <dbReference type="EnsemblBacteria" id="ABF90916">
        <property type="protein sequence ID" value="ABF90916"/>
        <property type="gene ID" value="MXAN_2298"/>
    </dbReference>
    <dbReference type="GeneID" id="41359685"/>
    <dbReference type="KEGG" id="mxa:MXAN_2298"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_7"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000051411" description="Asparagine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <sequence length="466" mass="52753" checksum="65AC1C6894E7A9E0" modified="2006-07-11" version="1">MQVVSVKKALAGGVEEGTKVEVRGWVRTRRDSKAGISFVNVSDGSTFDPIQVVAPNSLPNYEKEILHLTAGCSVISRGTLVKSQGKGQAYEVQADEVQVLGFVDDPDTYPIQPKQHTLEFLRDVAHLRVRTNTFSAVTRVRHRAAQAVHRFFDEEGFFWVNTPIITASDAEGAGQMFRVSTLDAVNPPRTSDGKIDWHKDFFGKEAYLTVSGQLNAEAYALAMSKVYTFGPTFRAENSNTTRHLAEFWMIEPEVAFADLNEDANLAERFLKHVFKAVLNDCAPDLKFFEERVQKGVIERMEKFINSSFERIDYTEAVEILKKAKKKFEFEPEWGKDLQTEHERYLTEEHVGRPVVVMNYPEAIKSFYMRLNDDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDQRIQKFGLKPESYQWYRDLRRYGSVPHAGFGLGFERLIVYMCGLQNIRDAIPYPRVPGSAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA08</accession>
    <name>Q1DA08_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552370.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2294"/>
    <dbReference type="EnsemblBacteria" id="ABF86887">
        <property type="protein sequence ID" value="ABF86887"/>
        <property type="gene ID" value="MXAN_2294"/>
    </dbReference>
    <dbReference type="GeneID" id="41359681"/>
    <dbReference type="KEGG" id="mxa:MXAN_2294"/>
    <dbReference type="HOGENOM" id="CLU_2586031_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="80" mass="8868" checksum="FF8EAEF542422050" modified="2006-07-11" version="1">MREIAPGAYDGAMSARPDLQRLPYQGLWLGSFPLMGIPGRAQAHSDHPVVALEQGDFLLVSLIRTSPEEIPQTTSIRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA75</accession>
    <name>Q1DA75_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2227"/>
    <dbReference type="EnsemblBacteria" id="ABF90160">
        <property type="protein sequence ID" value="ABF90160"/>
        <property type="gene ID" value="MXAN_2227"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2227"/>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033736_0_0_7"/>
    <dbReference type="OMA" id="VTHWIAS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="29806" checksum="2817293D4251DDBC" modified="2006-07-11" version="1">MHCRVATTQRELDDAVRVRWTVFGGELGLMTGWMPPSRREVSCFDTLDTTVHLVVYADAAPVATLRLLLPNPEVADAIGGRLGLELEQKLDLSEVVRPGMVVAETSRFCVLDGWRHSEAVTRLHAGIYEESRRRGVTHWLASANLDTDSREDAMLSCQVAAYRGWMSQRWRVDVPEPVDAPVIPSNPYYTPMERLRAEQGLLDGLRVPRAPTLFARKMGARFISEPLYDASFRRFTLPLIAALDEVPASTLARFNALAQHPLRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAC9</accession>
    <name>Q1DAC9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2171"/>
    <dbReference type="EnsemblBacteria" id="ABF91087">
        <property type="protein sequence ID" value="ABF91087"/>
        <property type="gene ID" value="MXAN_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2171"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862844_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="224"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="35066" checksum="EADDC4F38F13CCFB" modified="2006-07-11" version="1">MSTSGLFAVQSASGSELDAHFSLELLQGETTLLFESKGGGKDSPLGKRRNQDYDPGLRLILERLAQRGAKIRDASVDSDNVLDAGLPIEQRRLNVRAPFKLPVDLSLIDDFDKLRKALSAAQKPIGQRANAKGGNGQKKIRLYLDLNTQGTDLHSLGRSLATPTRSIVMSAGDIANTAETISASGHFDPHSIEDARARTLSAIVQRQGQSAFRKSLLEAYGNRCAITECDLEEVLEAAHILPFKGPATNTLENGLLLRADIHTLFDRGLIAVDTANWTILTHARITSTQYASLNKQHLRLPSRPELHPSTVALNKHRVESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAH4</accession>
    <name>Q1DAH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2125"/>
    <dbReference type="EnsemblBacteria" id="ABF89700">
        <property type="protein sequence ID" value="ABF89700"/>
        <property type="gene ID" value="MXAN_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2125"/>
    <dbReference type="HOGENOM" id="CLU_3366017_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="35" mass="3506" checksum="C0E3A6A103DBB714" modified="2006-07-11" version="1">MSVTFAKAPGNPKQDALLPAGAPASLGDVIPSRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI1</accession>
    <name>Q1DAI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552197.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2117"/>
    <dbReference type="EnsemblBacteria" id="ABF85923">
        <property type="protein sequence ID" value="ABF85923"/>
        <property type="gene ID" value="MXAN_2117"/>
    </dbReference>
    <dbReference type="GeneID" id="41359522"/>
    <dbReference type="KEGG" id="mxa:MXAN_2117"/>
    <dbReference type="eggNOG" id="ENOG5031D15">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407469_0_0_7"/>
    <dbReference type="OMA" id="VADCCIP"/>
    <dbReference type="OrthoDB" id="1900823at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188579" evidence="1">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="20452" checksum="D0499EA434736876" modified="2006-07-11" version="1">MTASFMKLRRLASLVLYCAALGVSPLASAEPPAAGEPAEAAPRAGELNYRSTGQRQPQITQLSDGGQQILLSCLLSRPGQIQRYAVSCPGTKQLDVKVADCCIPGDHWQVKVKSWDFKPNTAVATAPGGDGDFSAPARVFTYSSSRDMNALIECSYLHGVNVFPAESFLLVESSGGACSVTDVGITEEIDRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAP5</accession>
    <name>Q1DAP5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2049"/>
    <dbReference type="EnsemblBacteria" id="ABF89795">
        <property type="protein sequence ID" value="ABF89795"/>
        <property type="gene ID" value="MXAN_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2049"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976005_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="31866" checksum="21787ADA16BF73B6" modified="2006-07-11" version="1">MGVLGGRPPSAPGATPSPTSEPAAAPAPAASEPPRPDEARLAQQLEQRFADVQAKRDHFYVLGVSQDASRDQVKTAFLNLAKIFHPDRLPPSLPHMAPKITAVFEAIREAYEVLYDDTRRKTYQQNLQAQQTLPKPPSSAPTAPVLRPQGRADSNADDLYKMGEVFFRKRDFTTASDHYDRAHALEPKPLYLAARAWAIYMDPARKADMAKAKQMMADAVRADPNCDRAHYQLGVIARVEGDMDRAERCFREAVRANPKHLEANQELRLIDMRKKNPPKKGGFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB83</accession>
    <name>Q1DB83_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551946.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1844"/>
    <dbReference type="EnsemblBacteria" id="ABF89305">
        <property type="protein sequence ID" value="ABF89305"/>
        <property type="gene ID" value="MXAN_1844"/>
    </dbReference>
    <dbReference type="GeneID" id="41359261"/>
    <dbReference type="KEGG" id="mxa:MXAN_1844"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1414414_0_0_7"/>
    <dbReference type="OMA" id="VFFNQGD"/>
    <dbReference type="OrthoDB" id="1265640at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="20628" checksum="B73C04067F27BE4F" modified="2006-07-11" version="1">MSSFDDDLLAHDTRLLGMYVGYVTQREDEAQLGRVRVCIPGVLEPESAWAWPLGTSGGGAKDTGFFAVPEVGAEVAVFFNQGDVDAPYYLSAHWGRPGGQSEVPEEAQVSPPDNRVLATPTFRVELDESAGHRKLKLTNRKTGDCLTFDAEENTVTLEATTALTLRAVGAISLEAAQVTIAGRVVRPIAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB6</accession>
    <name>Q1DBB6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase HEAT-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1811"/>
    <dbReference type="EnsemblBacteria" id="ABF89661">
        <property type="protein sequence ID" value="ABF89661"/>
        <property type="gene ID" value="MXAN_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1811"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453304_0_0_7"/>
    <dbReference type="OMA" id="EAMGEAC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="602" mass="63957" checksum="BD5B319FD9E132D1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL9</accession>
    <name>Q1DBL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551813.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1703"/>
    <dbReference type="EnsemblBacteria" id="ABF91114">
        <property type="protein sequence ID" value="ABF91114"/>
        <property type="gene ID" value="MXAN_1703"/>
    </dbReference>
    <dbReference type="GeneID" id="41359141"/>
    <dbReference type="KEGG" id="mxa:MXAN_1703"/>
    <dbReference type="eggNOG" id="ENOG502Z9S8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452945_0_0_7"/>
    <dbReference type="OMA" id="LHYLRWV"/>
    <dbReference type="OrthoDB" id="1375571at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="20294" checksum="8A3B8DC86C9FAF7C" modified="2006-07-11" version="1">MEIKPQAMAIPRSTDHLERGKYGPIFPKTPACYGFTIVANVKPGRADAMRGYGQRVAEALKANPDLLAPLKLHYLRWVLFDDDTRFMYQGIFDTDFDKYTEDAVVLFTQSGINTAFENLEGFPMDWKTNTPAFIQFIRDHQCNSFLEYGEYPFFTGDEIKKALKIKAALAEMLEQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ3</accession>
    <name>Q1DBQ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine kinase associate protein KapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kapC</name>
        <name evidence="1" type="ORF">MXAN_1668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1668"/>
    <dbReference type="EnsemblBacteria" id="ABF91247">
        <property type="protein sequence ID" value="ABF91247"/>
        <property type="gene ID" value="MXAN_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1668"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_275181_0_0_7"/>
    <dbReference type="OMA" id="WAHREAE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1174" mass="125835" checksum="4B93A424520C16E5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBS5</accession>
    <name>Q1DBS5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551757.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1646"/>
    <dbReference type="EnsemblBacteria" id="ABF87595">
        <property type="protein sequence ID" value="ABF87595"/>
        <property type="gene ID" value="MXAN_1646"/>
    </dbReference>
    <dbReference type="GeneID" id="41359088"/>
    <dbReference type="KEGG" id="mxa:MXAN_1646"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_7"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="18763" checksum="6FF88AC8C5104E4D" modified="2006-07-11" version="1">MSDERLVLTRGDITQVQADAIVNAANSTLLGGGGVDGAIHRAAGPGLLAECRTLGRCPPGEARITGGHALPAKHVIHAVGPVWQGGSSGEETVLARCYRRAFSLMEQHGLGTIAFPSISTGAYGYPIERAARIALREILAALQRMPTLQRVTVVLFSDRDLDVYQRARQALEPTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC60</accession>
    <name>Q1DC60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551622.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86416">
        <property type="protein sequence ID" value="ABF86416"/>
        <property type="gene ID" value="MXAN_1511"/>
    </dbReference>
    <dbReference type="GeneID" id="41358957"/>
    <dbReference type="KEGG" id="mxa:MXAN_1511"/>
    <dbReference type="eggNOG" id="ENOG5032020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697954_0_0_7"/>
    <dbReference type="OMA" id="RARWFIP"/>
    <dbReference type="OrthoDB" id="662777at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="43193" checksum="41C3434810024780" modified="2006-07-11" version="1">MIVGDTLSRYSARRSQLLSGTASPGEVLEAAGDLLRRRSRLETEGVDAALRGLGRSQVEAWLKAQKPQSLQPVLLRAAEEAVEVALDGGEEADMWRVSALEGLSARDRAASAAHALAVWEGFHGALDGESAQLRDRFLAALQSLDSALRPRARWFIPLNPQRRQERDLIEPAEQDAAWWFSARAGCDDLVATWTANPQTLTAHLQDCDACRADMADAAPVDMPPRRHLTADDLWRLDMGLLSEDERTRLDAHTARCGECAQAVLALDEGEAAIEEALDMEEDGTVARSARTSRAPVSHRAHAARLPEQREVLDERRDFRVVLVRERQRVRLLVQPLSGRTVTAAVFLSPGRPSLKPAHGPEGIAFDLTSASSTGARSAHLSVQAGSETLERDFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB9</accession>
    <name>Q1DCB9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1447</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551563.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1447"/>
    <dbReference type="EnsemblBacteria" id="ABF91353">
        <property type="protein sequence ID" value="ABF91353"/>
        <property type="gene ID" value="MXAN_1447"/>
    </dbReference>
    <dbReference type="GeneID" id="41358893"/>
    <dbReference type="KEGG" id="mxa:MXAN_1447"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_7"/>
    <dbReference type="OMA" id="MAMSVGQ"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="138" mass="14961" checksum="3981A7826C8C01B1" modified="2006-07-11" version="1">MGMSAGPKGSVKSDINVTPLVDVVLVLLIIFMVVTPMLQRGKSVELPKATEIEKEGKGKEADPLILSITPDKKVFVENDQVDEKGLQEKLTAEIEKDPGKKILLKGDNALSVGDVRKVLDVARKSKAKQISLGVEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW3</accession>
    <name>Q1DCW3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87216">
        <property type="protein sequence ID" value="ABF87216"/>
        <property type="gene ID" value="MXAN_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1251"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2684046_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="74" mass="7792" checksum="A6216CCBE0D37B87" modified="2006-07-11" version="1">MAAASYVTFNTPVEDGTVRWVSYDSPEAIAAKGAYARDNGFGGTIIWTLNQGCTNPTTGANPLLDAVKGAFLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCX3</accession>
    <name>Q1DCX3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1241"/>
    <dbReference type="EnsemblBacteria" id="ABF86111">
        <property type="protein sequence ID" value="ABF86111"/>
        <property type="gene ID" value="MXAN_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1241"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1990236_0_0_7"/>
    <dbReference type="OMA" id="ETYERGI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16547" checksum="3CB44F4E6AFB6B3B" modified="2006-07-11" version="1">MPDTVFFRAAGARVVVFFAVVFFFVAMCGAPYRTLGNTEAVLYLLVSMSDARLEQFKKMVVDFPDSPMSHFSLGKLYLERRQYPEAAQALESAVRLDPTYAAAMVALGDAWAGAGESDKAREVLGRAREHALAQGHPGLAEEIDERIADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD47</accession>
    <name>Q1DD47_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551286.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1DD47">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1166"/>
    <dbReference type="EnsemblBacteria" id="ABF89976">
        <property type="protein sequence ID" value="ABF89976"/>
        <property type="gene ID" value="MXAN_1166"/>
    </dbReference>
    <dbReference type="GeneID" id="41358618"/>
    <dbReference type="KEGG" id="mxa:MXAN_1166"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582546_0_0_7"/>
    <dbReference type="OMA" id="EMLAQCE"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="239"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="476" mass="51024" checksum="A77060A595962CEC" modified="2006-07-11" version="1">MASSRIPIRGYRAGFFFVVVLLSAVTAFTLWTEVRTGSQVDGLVQEALERAGSIGRIRVDALSLEAAIEAHVRATGDAERRAADAVMEQILADIRASSEAYTRNLPQGEKALWYRFNAACQGLADQVRAAAIFSQRREAERARRHLAERIRPLAAELDALGGALEEENAAEARRLVNRLEDLRVRNTALGAGATLLAILLSSLVGWRVTSLLKRQEAIIQGQLEELGRHNQELDAFTRRVAHDLISPLAPLKGYLTLIRRTGAVNDAGALEMLAQCESSAVRMGELIEALLRFCRAGTRGESTVGELDTAVTTVLLEVAQTAAAQGVALERELEPGVAVDCPGQLLQVSARNLLTNAVKYSAGRPDPRVKVRVATEDGMAVLEVVDNGIGMAPGTQASLFQPFFRAPEVRGLPGHGLGLVTTKRVVEAHGGTLVVRSEEGKGTHVVVRFPRVVRPAAGTSGSQTTTASAGMRKVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDG1</accession>
    <name>Q1DDG1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551172.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1051"/>
    <dbReference type="EnsemblBacteria" id="ABF91775">
        <property type="protein sequence ID" value="ABF91775"/>
        <property type="gene ID" value="MXAN_1051"/>
    </dbReference>
    <dbReference type="GeneID" id="41358504"/>
    <dbReference type="KEGG" id="mxa:MXAN_1051"/>
    <dbReference type="HOGENOM" id="CLU_1336314_0_0_7"/>
    <dbReference type="OMA" id="TNWPAGS"/>
    <dbReference type="OrthoDB" id="1994718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="21500" checksum="4F645AA26EEF5E02" modified="2006-07-11" version="1">MLSIVAAALLATASTSTSHSLLTPVSERPVSTRLLVAQAPAEAPDVSGTSTPPPLPEDLDARARELTQQIAMLQSEIRSVDTNWPAGSLVMAYSGYVLSPLLLLGIPLIIVGMSSSNDDDAGTLLALGVGTTLGGVAGVGLLIAGIVTGSKQAGINRAHRESLVRERIRLEDELRDVKARRDARGAMQTRQWTPRAGIPLVAFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM8</accession>
    <name>Q1DDM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heavy metal efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551105.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0984"/>
    <dbReference type="TCDB" id="2.A.6.1.7">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87930">
        <property type="protein sequence ID" value="ABF87930"/>
        <property type="gene ID" value="MXAN_0984"/>
    </dbReference>
    <dbReference type="GeneID" id="41358440"/>
    <dbReference type="KEGG" id="mxa:MXAN_0984"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_3_7"/>
    <dbReference type="OMA" id="GAFHLNN"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="73"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="41844" checksum="687318C6F9D36D8D" modified="2006-07-11" version="1">MKPLHAAVAALLLLTACKRETPHDAQAHGHDEPPAQAGAHHDDHGEPHVRIASEMLRDLRITTAPVGVRPGGENVTVLGELTFSEDAYAEVASPIAARVSAVFVTTGQAVKQGEKLADLRSPELGKARAALQAAQAQAQAARQAAERKRTLADERIIASKDVQAAEAEAAAAEASVAAARAELVALGVSEEELRGGNVPPGFVLRAPLSGTVVERTARMGQMADPNLPLFCIGDVSSLWLVVHAFERDAVRIQRGTQARITFAAFPGQEFMAKVGHVGQRVDATSRTIPVRLELDNADGQLRPGMSASAYIPLGDPGAPITAVPAAALQRLEGGWVAFLPTDTRGVFERREVGRGRTLGGDVEVLTGLKPGEQVVVEGAFLLKAEAEKLSGGGSDGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDU4</accession>
    <name>Q1DDU4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-amino-3-carboxylmuconate-6-semialdehyde decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551039.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0918"/>
    <dbReference type="EnsemblBacteria" id="ABF92871">
        <property type="protein sequence ID" value="ABF92871"/>
        <property type="gene ID" value="MXAN_0918"/>
    </dbReference>
    <dbReference type="GeneID" id="41358377"/>
    <dbReference type="KEGG" id="mxa:MXAN_0918"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_1_2_7"/>
    <dbReference type="OMA" id="TTNYKAI"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001760">
        <property type="term" value="F:aminocarboxymuconate-semialdehyde decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="3"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="38042" checksum="B608ECB755E088CA" modified="2006-07-11" version="1">MKVDIHTHLLPAHLPRFAERYGYGGFITLDHHAPCRARMLRDDGKFFREIESNCWDPVKRIEECDAAGVHVQVLSTIPVMFGYWTKPEHGADLARFLNDHLASVVHAHPKRFVGLGTVPLQSPELAVRELERCVKELGLAGVQIGSHVNDWNLSDPALFPFFEAASELGASVFVHPWDMMGEAKMQKYWLPWLVGMPAEVSLAICSVIFGGVLERLPKLRFAFAHGGGAFPHTLGRIQHGFEARPDLVAVDNKVPPRDYLGRFWVDSLVHDPEALRYIVRLFGQDKVALGSDYPFPLGEDRPGTLIESLTELEPAARERLLWRNAFDWLGRAPEDFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE45</accession>
    <name>Q1DE45_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92520">
        <property type="protein sequence ID" value="ABF92520"/>
        <property type="gene ID" value="MXAN_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0815"/>
    <dbReference type="HOGENOM" id="CLU_1775454_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="146" mass="15105" checksum="20AA2A6E34D541D7" modified="2006-07-11" version="1">MTGRRPDSSTWMGRRVEMGTVAPPASASFTTACNGTCTPSRDWSGSTSTVTPPGSSPSTPLATPPATATSPTTSGALSKSTRSTCRKSSDAVRSFTSLLAEAPATRSEGSAPAPQGRMSNRSRAGRRTSPHAEWVTAGRVPAERIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE89</accession>
    <name>Q1DE89_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase, pfkB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550894.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0768"/>
    <dbReference type="EnsemblBacteria" id="ABF87063">
        <property type="protein sequence ID" value="ABF87063"/>
        <property type="gene ID" value="MXAN_0768"/>
    </dbReference>
    <dbReference type="GeneID" id="41358237"/>
    <dbReference type="KEGG" id="mxa:MXAN_0768"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061466_0_0_7"/>
    <dbReference type="OMA" id="ESGFFHL"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019140">
        <property type="term" value="F:inositol 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010264">
        <property type="term" value="P:myo-inositol hexakisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031094">
        <property type="entry name" value="MIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085:SF13">
        <property type="entry name" value="PTHR43085:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="125"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="29877" checksum="4FF796212732099D" modified="2006-07-11" version="1">MGDASLRDVLVVGSYCHDLLRHGPGRETHALGGSAAYIASVLDAMGLEYAVAAVAGEDFRYADQVRHPPRIVPGTRTTQFIADFEGEARTLRVSAKAEPIRPADITVDARVALACGVAGEVLPETLLHVSERARHVLADAQGLIRALDDDGRVLNLRLEDTPFAGLLERLRVLKASEEEARAMDIERVRQRTCLVVTRGARGCTVFTADARIDVPTVAVEEVDATGAGDCFIAGFTLGLLRGLPFERCAALANWFGAQAVTQVGVPKLDVSRLPTELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA5</accession>
    <name>Q1DEA5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550878.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0752"/>
    <dbReference type="EnsemblBacteria" id="ABF91880">
        <property type="protein sequence ID" value="ABF91880"/>
        <property type="gene ID" value="MXAN_0752"/>
    </dbReference>
    <dbReference type="GeneID" id="41358222"/>
    <dbReference type="KEGG" id="mxa:MXAN_0752"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511813_0_0_7"/>
    <dbReference type="OMA" id="DACVPQG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="57483" checksum="3F7923061244F0F5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB7</accession>
    <name>Q1DEB7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550866.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0740"/>
    <dbReference type="EnsemblBacteria" id="ABF89200">
        <property type="protein sequence ID" value="ABF89200"/>
        <property type="gene ID" value="MXAN_0740"/>
    </dbReference>
    <dbReference type="GeneID" id="41358211"/>
    <dbReference type="KEGG" id="mxa:MXAN_0740"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830831_0_0_7"/>
    <dbReference type="OMA" id="FFMSFRG"/>
    <dbReference type="OrthoDB" id="748767at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="34826" checksum="04CADF451469CE27" modified="2006-07-11" version="1">MAPATGATDMRVRHARGQSLVETALGVMVFVTILLFGIYFAEVGALTLKVQEAANFAMWNATGRVMHDPQDNEWGRRGTVLAAEAEANGRYADFDGRQRMGRTGVAVQQAIARAQPIQVDCRPELPGTVRGLSMADADPDLAGTIAMGTQGMGCTASSSIRGVRIGRYLENGREGFFKVSQRRAADAFTVCAAGRASGGRCTARFGMLLDDWGLGGVEEGRACALNINGARRCANPDYYEWAQRVYRANGAGGNAGSALAAITGAAGVNEDQFFMSFRGEEDNYEENLGSTHAGGQTRWEVTPFDAPNIRSYKVGRASHWLGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF4</accession>
    <name>Q1DEF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550829.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0701"/>
    <dbReference type="EnsemblBacteria" id="ABF89358">
        <property type="protein sequence ID" value="ABF89358"/>
        <property type="gene ID" value="MXAN_0701"/>
    </dbReference>
    <dbReference type="GeneID" id="41358174"/>
    <dbReference type="KEGG" id="mxa:MXAN_0701"/>
    <dbReference type="HOGENOM" id="CLU_1553629_0_0_7"/>
    <dbReference type="OMA" id="GAFHIEG"/>
    <dbReference type="OrthoDB" id="1779377at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="22225" checksum="D9128530D4886DDE" modified="2006-07-11" version="1">MTGAGSPRQWLHDDCLSILAAPAALEVAMKRLSLKSSFAVASCVSGIAALAFTVAPSAAFAQVPPPEFSLVECTQGNQSQNYAPAITLFARLVSVTGSGQFSSCLDETNPGIAFGSFTITGNGAASCLMASVPTQNTVTWNDGSQSVIEFIDGVDVRPVGMTMVTLLGRVSSGRYENALAIKTLDVSSVPGVTQCVLGGVRSATKNVSLSLLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ0</accession>
    <name>Q1DEJ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550796.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0665"/>
    <dbReference type="EnsemblBacteria" id="ABF89539">
        <property type="protein sequence ID" value="ABF89539"/>
        <property type="gene ID" value="MXAN_0665"/>
    </dbReference>
    <dbReference type="GeneID" id="41358140"/>
    <dbReference type="KEGG" id="mxa:MXAN_0665"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085144_0_0_7"/>
    <dbReference type="OMA" id="TIFYEGM"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="28836" checksum="21C7626A91BA71C5" modified="2006-07-11" version="1">MVNDRRVRNPASMARPADPHARSALVSAARREFARRGLKGARIEDITAACGLSKGAFYLHFPSKEALFGEVVGAFESGLMEMNGRRMARMEGFFQTHGIPGAQDRIERSDRYLRFLQLEKEHDLEALDWVWEFRDVSLVLTSGSQGTEFESLLWRVTDAQVERISHDFRRLQEAGAMDPELDARIFASIIVGSFLLLSTQMARLDEKPDLNAWANTLQRLCQEGTRPASPAPSKRVARRPRAAAEKPRKTPRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ0</accession>
    <name>Q1DEQ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550736.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0605"/>
    <dbReference type="EnsemblBacteria" id="ABF90373">
        <property type="protein sequence ID" value="ABF90373"/>
        <property type="gene ID" value="MXAN_0605"/>
    </dbReference>
    <dbReference type="GeneID" id="41358083"/>
    <dbReference type="KEGG" id="mxa:MXAN_0605"/>
    <dbReference type="HOGENOM" id="CLU_2143159_0_0_7"/>
    <dbReference type="OMA" id="SDYVCTC"/>
    <dbReference type="OrthoDB" id="2004695at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188219" evidence="1">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="112" mass="12407" checksum="CC6A33A313D617EA" modified="2006-07-11" version="1">MLRLQLQSLSPHGVRPMKKAFLIALSLSLPAFASSDFDSEDLSVDVDPEELVSQEAADASRPPLLQFCWNLHYTSCSGPGTTQQCTDGIWSDYVCTCRTLGTRNVWVCPEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEV8</accession>
    <name>Q1DEV8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550678.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0546"/>
    <dbReference type="EnsemblBacteria" id="ABF86484">
        <property type="protein sequence ID" value="ABF86484"/>
        <property type="gene ID" value="MXAN_0546"/>
    </dbReference>
    <dbReference type="GeneID" id="41358030"/>
    <dbReference type="KEGG" id="mxa:MXAN_0546"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051161_0_0_7"/>
    <dbReference type="OMA" id="LYWPASY"/>
    <dbReference type="OrthoDB" id="1885303at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="Cupin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="151"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="48392" checksum="B14D5A0D9CDE9DA0" modified="2006-07-11" version="1">MARIDLQRRFDWDTFVTRYWNQRPVLYQATGINPFMDTDVFDAALGASRGAMEPPTALEARTDVQFTIDQGQPVQLGPWLPRDTDGSLDGYDSRLADALGTRRYALIISLLHSHGFGLWSRERAFFSDLWRRVGLPLSGGITTLFHGNYEHSPVGVHLDRFTTFLFAIRGRKRMRFWAKRPWSMPVTTLVDYAPYLAKSFTAEVGPGDILYWPASYYHVGESASRDVATSVNVGIPVTGHQARYDVEDLVGPGHSNAPRTRDTVRGRALVPGVLDGDGVLPRELPAALRQAANTLRENSRDARTQAHIRTLWLNRRSAGGLEPPPPPARRRPLKDTDILHGNKSFPILLEKTGTGWCCSANGNALHVSGLRQPVNKLVATLNTARTVSVGELLHPFPSRGDLPLRALKPLPATRAGMRRMLEILLTFRAIQLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFB0</accession>
    <name>Q1DFB0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0392"/>
    <dbReference type="EnsemblBacteria" id="ABF89753">
        <property type="protein sequence ID" value="ABF89753"/>
        <property type="gene ID" value="MXAN_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0392"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022425_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="29794" checksum="3E87984D544CAEB3" modified="2006-07-11" version="1">MREQLRGLVESLSEDVHWQHLSDEQDADVLALLSDTWVLRYALEGQARILERLVDRVSETPDARLRAVLIRSLQQTGEPSTQLLGIQVLQGRDVYRDWVTDAAPEVRAAAVENFREEAARNAGRYRVVAERAVSLATVAEDPATAAGLLGASSIEAVRGPSVAQVRTLLQSPKSPVVRAAAARALATSPVTELSASLDALAARYSAEPEASVRAALLESISRLGLSRAVPVLERLRDTNAAARDEVNPWIALLAEHPQRWEMLDTARRHSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN4</accession>
    <name>Q1DFN4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0258"/>
    <dbReference type="EnsemblBacteria" id="ABF88152">
        <property type="protein sequence ID" value="ABF88152"/>
        <property type="gene ID" value="MXAN_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0258"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1833006_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="15126" checksum="6CB34C05D2D177AE" modified="2006-07-11" version="1">MGRHLRGGGAGRRGHVLLRPGGVPSMRGERPILLAEGDLPRLDGHEVLRRIRADARTRMLPVVILSASAEEAVAARGPQGRVQVADRGSGISEDLVKHVFERFGRALSSRADGGRAWAGPREGGGARFTLDLPLEKERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFV0</accession>
    <name>Q1DFV0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0191"/>
    <dbReference type="EnsemblBacteria" id="ABF89872">
        <property type="protein sequence ID" value="ABF89872"/>
        <property type="gene ID" value="MXAN_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0191"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089498_0_0_7"/>
    <dbReference type="OMA" id="HFDHHQD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="28729" checksum="79536D45E7E90F33" modified="2006-07-11" version="1">MTLGDLIYSFFTYYAVVAYITVGIISLVFAVKWFENPLRMLLAMLAASVAFPFGWYLVHKHILHSRFLYKSPLTAATWKRIHFDHHQDPHDLRVLFGALANVLPTVGGVIAPIGYLIGGKAGAAAALGWAMVITCFYEFCHCIQHLNYTPKSQFLKDIKRLHLSHHFHNEQGNYGITNYFWDRLFGTFYEKSGDKPKSPTVFNLGYTAEEAQRYPWVDRLSGGTRGDGHPRRFWENQADAKTPPEPATRQES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG16</accession>
    <name>UPP_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">MXAN_0124</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550271.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DG16"/>
    <dbReference type="SMR" id="Q1DG16"/>
    <dbReference type="STRING" id="246197.MXAN_0124"/>
    <dbReference type="EnsemblBacteria" id="ABF86250">
        <property type="protein sequence ID" value="ABF86250"/>
        <property type="gene ID" value="MXAN_0124"/>
    </dbReference>
    <dbReference type="GeneID" id="41357629"/>
    <dbReference type="KEGG" id="mxa:MXAN_0124"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_7"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000053746" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <sequence length="211" mass="23337" checksum="3438DC586EA5BBCD" modified="2006-07-11" version="1">MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTPMARTVAPVLDGKKLVLVAIMRAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRVPGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFVCLLACPEGLTNLREHHPDVHVYTAAIDERLDEHGYILPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG45</accession>
    <name>Q1DG45_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550242.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0095"/>
    <dbReference type="EnsemblBacteria" id="ABF88787">
        <property type="protein sequence ID" value="ABF88787"/>
        <property type="gene ID" value="MXAN_0095"/>
    </dbReference>
    <dbReference type="GeneID" id="41357602"/>
    <dbReference type="KEGG" id="mxa:MXAN_0095"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_7"/>
    <dbReference type="OMA" id="QNARYHA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="328"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="391"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="645"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="768" mass="84749" checksum="10020E4338274E8F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVP4</accession>
    <name>Q1CVP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557334.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7423"/>
    <dbReference type="EnsemblBacteria" id="ABF92636">
        <property type="protein sequence ID" value="ABF92636"/>
        <property type="gene ID" value="MXAN_7423"/>
    </dbReference>
    <dbReference type="GeneID" id="41364578"/>
    <dbReference type="KEGG" id="mxa:MXAN_7423"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119019_0_0_7"/>
    <dbReference type="OMA" id="EFAKWCT"/>
    <dbReference type="OrthoDB" id="1200118at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20770" checksum="2E5D644717B9598C" modified="2006-07-11" version="1">MGTARRGQPDWDRLFDIVAGQSGLFTAQQALEAGYSPQVLAHHVGAGRFHRVRRGIYRLVHFPAGEHEDLVAVWLWSEQQGVFSHQTALALHNLSDVLPSRMHLTLPAAWRQRRFRAPAGTVLHHADVGETERVWFGPIPGTSPRRTLLDCAAAQVSPDLLNQAIAQALSRGLILTSDLAGIQSAAQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVT7</accession>
    <name>Q1CVT7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ArsA_ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557291.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7379"/>
    <dbReference type="EnsemblBacteria" id="ABF87932">
        <property type="protein sequence ID" value="ABF87932"/>
        <property type="gene ID" value="MXAN_7379"/>
    </dbReference>
    <dbReference type="GeneID" id="41364538"/>
    <dbReference type="KEGG" id="mxa:MXAN_7379"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044079_0_0_7"/>
    <dbReference type="OMA" id="LDVWMLD"/>
    <dbReference type="OrthoDB" id="1347467at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="40289" checksum="CF45F78B07FE1329" modified="2006-07-11" version="1">MSAGDLRRLLRDKRIVVLCGAGGVGKTTTAAALGVAAARAGRRVLVLTIDPARRLAETMGLQESGPEPTSIPSERLFADGPWGTGLLDVWMLDPRAIFERMVHQLAPTPEAARAIVDHRLYRFLSELVAGVQEYAAAEALDAFLTDGRYELILLDTPPSRHALDFLDAPGRLARFLDERIVSLFGPEKRARGGRLWHGAQAVVDRVLAGIFGAGFTQEMRGFIGAFGGLFSGMRLHTERLHQRLASPDAAFLLVTSPEPASLREATWFRETLAARGLPFAGYVLNRSWAHDDVLAAPEALLEHTGGDRHAEQAVAALSRLASVEQARAQAHRDVLDRLTRHLPSGTLAVAAPDAGAELEEFSGLVRLGDALAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVX2</accession>
    <name>Q1CVX2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557257.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87655">
        <property type="protein sequence ID" value="ABF87655"/>
        <property type="gene ID" value="MXAN_7338"/>
    </dbReference>
    <dbReference type="GeneID" id="41364499"/>
    <dbReference type="KEGG" id="mxa:MXAN_7338"/>
    <dbReference type="HOGENOM" id="CLU_2317331_0_0_7"/>
    <dbReference type="OMA" id="MNVDEHI"/>
    <dbReference type="OrthoDB" id="1951552at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="100" mass="11135" checksum="4449322DE80B2954" modified="2006-07-11" version="1">MNVDEHIQRARELLARNQPEMAESALSDAIDAAIAAEDIVLLTRARFALGELLFHQGRDAEAVPYLQAVVRTERVDGAVDVEVKASARMLRQIRGIEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD4</accession>
    <name>Q1CWD4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein, GspE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557095.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7176"/>
    <dbReference type="EnsemblBacteria" id="ABF89058">
        <property type="protein sequence ID" value="ABF89058"/>
        <property type="gene ID" value="MXAN_7176"/>
    </dbReference>
    <dbReference type="GeneID" id="41364349"/>
    <dbReference type="KEGG" id="mxa:MXAN_7176"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_2_2_7"/>
    <dbReference type="OMA" id="ILPTNHG"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="140"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="515" mass="55062" checksum="D543D8AA59D925E3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD6</accession>
    <name>Q1CWD6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557093.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7174"/>
    <dbReference type="EnsemblBacteria" id="ABF86787">
        <property type="protein sequence ID" value="ABF86787"/>
        <property type="gene ID" value="MXAN_7174"/>
    </dbReference>
    <dbReference type="GeneID" id="41364347"/>
    <dbReference type="KEGG" id="mxa:MXAN_7174"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_5_7"/>
    <dbReference type="OMA" id="NRVANWT"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="117" mass="13618" checksum="CCE2599AA7FF3AA7" modified="2006-07-11" version="1">MEKRNNRVANWTRLHRRFGDHVRKLRTARELTQEALAERSDLSVDAIRRIERGSFSPSLDTLGKLSKGLDVSLKTLFQGFERERSNAVAEICDFLSLRSGREVELAWRVIQAMFEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG9</accession>
    <name>Q1CWG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557060.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89036">
        <property type="protein sequence ID" value="ABF89036"/>
        <property type="gene ID" value="MXAN_7141"/>
    </dbReference>
    <dbReference type="GeneID" id="41364315"/>
    <dbReference type="KEGG" id="mxa:MXAN_7141"/>
    <dbReference type="eggNOG" id="ENOG5032JN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509056_0_0_7"/>
    <dbReference type="OMA" id="ILWAGCV"/>
    <dbReference type="OrthoDB" id="1213685at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="20400" checksum="D5CD8ABDEFB6718E" modified="2006-07-11" version="1">MTSLARPARLTWQNGGTFLRVLLTQVLYVAPLFWFMELAQNVAWRWMNGDWGWVFPKSPYHWFSFGSLILWAGCVALLWSLHFFWFYPRRVKVWPRLAIGAGVCWAGEWVGGYVAANVFNHPLQVWPGSPLVYVHYSALFFWVSNCIVYHLLTNDVVDLTPEYDAPPTTTRRAQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWM9</accession>
    <name>Q1CWM9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557000.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7081"/>
    <dbReference type="EnsemblBacteria" id="ABF87705">
        <property type="protein sequence ID" value="ABF87705"/>
        <property type="gene ID" value="MXAN_7081"/>
    </dbReference>
    <dbReference type="GeneID" id="41364256"/>
    <dbReference type="KEGG" id="mxa:MXAN_7081"/>
    <dbReference type="HOGENOM" id="CLU_1401178_0_0_7"/>
    <dbReference type="OMA" id="CSAVGWC"/>
    <dbReference type="OrthoDB" id="1854766at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="21275" checksum="C45C1416D6164E4E" modified="2006-07-11" version="1">MKNLTRALVLSLSLLAVSCGDSKEDDKDGEGGGGGGGGGNALQCSAVGWCTTWSADPNEVTNAPPLTGGTLREGTYRVEQGNGYDAAMVLRGSSVILLGGSWNNYLGTWKVSNGKLELTRASSCDDYSEGPLDNLVTEVHAFAVRGDELFTQDQDDSRGTILRWKRVSDLCEESASFKCRGGLCSCATTTNRPMTGQQSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ5</accession>
    <name>Q1CWQ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7055"/>
    <dbReference type="EnsemblBacteria" id="ABF90655">
        <property type="protein sequence ID" value="ABF90655"/>
        <property type="gene ID" value="MXAN_7055"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7055"/>
    <dbReference type="HOGENOM" id="CLU_2106330_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="115" mass="12782" checksum="E12F23D26784D029" modified="2006-07-11" version="1">MLRGRDFPGRGEEAVPSVVEQDFSAHDFTHVRQGHREVMPADEALLHDEFIPRHLDDASENVPVVAAHLHPLVDFRTTEHGCLPQGGPWSPVRESWLSPRKLAADRRGAAPVKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWU4</accession>
    <name>Q1CWU4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas4</name>
        <name evidence="8" type="ORF">MXAN_7016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556935.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7016"/>
    <dbReference type="EnsemblBacteria" id="ABF86497">
        <property type="protein sequence ID" value="ABF86497"/>
        <property type="gene ID" value="MXAN_7016"/>
    </dbReference>
    <dbReference type="GeneID" id="41364192"/>
    <dbReference type="KEGG" id="mxa:MXAN_7016"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_1_1_7"/>
    <dbReference type="OMA" id="QQWVWSD"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="24186" checksum="26333010DFE90D43" modified="2006-07-11" version="1">MSTDRETWVALSALQHLLYCERQAALIHVERQWREDVNTASGRLLHERVDLPGHDARLGRRVERAVLLGSQRLRVSGRADMVEYQRDAKGAGWRPFPVEVKRGRRKAGEADRVQLCAQALCLEEMHGVDVPEGALFYGVEHKRAAVRFDAELRQRTEDAIARMHEVLRRQEVPVVARAPRCDKCSLEPLCLPGVTAGQRSAQDFLMQWMALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX07</accession>
    <name>Q1CX07_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6951</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556872.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6951"/>
    <dbReference type="EnsemblBacteria" id="ABF88527">
        <property type="protein sequence ID" value="ABF88527"/>
        <property type="gene ID" value="MXAN_6951"/>
    </dbReference>
    <dbReference type="GeneID" id="41364129"/>
    <dbReference type="KEGG" id="mxa:MXAN_6951"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_2_1_7"/>
    <dbReference type="OMA" id="QLEACMR"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="266"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="458"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="609"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="726" mass="76707" checksum="0E10F045DC86073E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX81</accession>
    <name>Q1CX81_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556800.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6877"/>
    <dbReference type="EnsemblBacteria" id="ABF90313">
        <property type="protein sequence ID" value="ABF90313"/>
        <property type="gene ID" value="MXAN_6877"/>
    </dbReference>
    <dbReference type="GeneID" id="41364064"/>
    <dbReference type="KEGG" id="mxa:MXAN_6877"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_7"/>
    <dbReference type="OMA" id="HYTAAKT"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="26796" checksum="B8E70A9BC0AFCED2" modified="2006-07-11" version="1">MSEVGTRKVLVTGGGTGIGRAVAEALLRAGGQVVVSGRRVEVLESLTTAWPGQAFALPCDLASLEAREGLLRRAAGLLGGLDGFVHSAGQVVHQPPGHIGEDALRAQLEVNLIAPLRLGEQALEVLEPGGAQVFIASTLATRPVVTSAVYSAAKAGLLQVMKVLALVGAARGVRASAVLPGVVETDMVREVRLAPGAGPLSEPEYARRQEAQLAGLRALHPLGRLGRPEDVAEAVRYLLGASWISGSELVLDGGLLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC9</accession>
    <name>Q1CXC9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sodium ABC tranporter ATP-binding protein NatA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">natA</name>
        <name evidence="5" type="ORF">MXAN_6827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556752.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6827"/>
    <dbReference type="EnsemblBacteria" id="ABF90665">
        <property type="protein sequence ID" value="ABF90665"/>
        <property type="gene ID" value="MXAN_6827"/>
    </dbReference>
    <dbReference type="GeneID" id="41364016"/>
    <dbReference type="KEGG" id="mxa:MXAN_6827"/>
    <dbReference type="eggNOG" id="COG4555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26752" checksum="784F28215BD6CEDD" modified="2006-07-11" version="1">MIEARNLHKRFGKKVTAVEDVSFTAEDGVITGLLGPNGAGKTTTMRMLYTLVRPDRGTALVDGVDVVQRPQEARRALGVLPDARGLYPRLTAREHARYYGELHGLSGAALDKRVDELLDLLDMRDIADRRTEGFSQGQRVKVALARALVHGPRNVLLDEPTNGLDVMSTRSVRTLLRRLKDEGRCVVFSSHVMQEVAALCDRIVVVAHGRVVADGTPDALRASTGKDSLEEAFVATIGTDQGLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXH8</accession>
    <name>Q1CXH8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556703.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6778"/>
    <dbReference type="EnsemblBacteria" id="ABF89547">
        <property type="protein sequence ID" value="ABF89547"/>
        <property type="gene ID" value="MXAN_6778"/>
    </dbReference>
    <dbReference type="GeneID" id="41363969"/>
    <dbReference type="KEGG" id="mxa:MXAN_6778"/>
    <dbReference type="eggNOG" id="COG3806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304250_0_0_7"/>
    <dbReference type="OMA" id="RYPRHTH"/>
    <dbReference type="OrthoDB" id="1792151at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="216" mass="23360" checksum="E5EFDEC1468353AB" modified="2006-07-11" version="1">MTARNVTMAHHLDDILPEWALGMLEAPARASVEQHLAECARCREVADRLVSTHAALASLVVPPPAVLARLMDQMEGPGRLARFADRVAAFFDLSRERALALLDAVSDPAAWMPGPVEGSELMPVETGPAREGTMAAILRLHPGVRYPRHTHHGREWNLVLEGGFREDDGHEVWPGEELEKTDGSAHGFTALTEGPACLCASVLEGVTSFEEAFADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY5</accession>
    <name>Q1CXY5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556546.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6620"/>
    <dbReference type="EnsemblBacteria" id="ABF87592">
        <property type="protein sequence ID" value="ABF87592"/>
        <property type="gene ID" value="MXAN_6620"/>
    </dbReference>
    <dbReference type="GeneID" id="41363818"/>
    <dbReference type="KEGG" id="mxa:MXAN_6620"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="LVITDYM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13616" checksum="802C68B858F3E6D3" modified="2006-07-11" version="1">MGPILIVDDEFGIVEAMRDLLSDEGYRTAIALNGKEALERMAEEHPCLVLLDYMMPVMNGPALLEAMERNPLLRDIPVVMMSASPPDYWKHLRCAAFLPKPFSLDELLVMVKRFAQGAILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY29</accession>
    <name>Q1CY29_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6572"/>
    <dbReference type="EnsemblBacteria" id="ABF92777">
        <property type="protein sequence ID" value="ABF92777"/>
        <property type="gene ID" value="MXAN_6572"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6572"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585478_0_0_7"/>
    <dbReference type="OMA" id="LWRICTH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="63"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="16780" checksum="D491D8CEFF6B591D" modified="2006-07-11" version="1">MDRRAALGTLLKGTCALAAVGAGCGDGWREAVVLDPPDAGGPGPSCAPPVPSGPPGEGWVEVPLVEHPALEVPGGAAEVRIPQALLDVVVVHTSPGCYAALWRICTHGDCAVDWVPADGVMECPCHGSRFTQEGQVLNGPATRPLAAFPVVRQGASLFIHRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY35</accession>
    <name>Q1CY35_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6566"/>
    <dbReference type="EnsemblBacteria" id="ABF89340">
        <property type="protein sequence ID" value="ABF89340"/>
        <property type="gene ID" value="MXAN_6566"/>
    </dbReference>
    <dbReference type="GeneID" id="41363771"/>
    <dbReference type="KEGG" id="mxa:MXAN_6566"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_7"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
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        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="12846" checksum="75544CDEDC09886B" modified="2006-07-11" version="1">MSDCLFCKIRDGLIPAKVVYRDDVCVAFEDINPQAPTHVLFIPHKHIPTVNDITTEDRELVGHLFIAAAKVAQERGHADPSDGYRVVMNTHAHAGQTVFHIHLHLLAGRPLGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY50</accession>
    <name>Q1CY50_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oligopeptide/dipeptide ABC transporter, periplasmic oligopeptide/dipeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556481.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6551"/>
    <dbReference type="EnsemblBacteria" id="ABF88665">
        <property type="protein sequence ID" value="ABF88665"/>
        <property type="gene ID" value="MXAN_6551"/>
    </dbReference>
    <dbReference type="GeneID" id="41363756"/>
    <dbReference type="KEGG" id="mxa:MXAN_6551"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_7"/>
    <dbReference type="OMA" id="DWMMMCE"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="72"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="546" mass="61517" checksum="E95973ED3779CBC1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY55</accession>
    <name>Q1CY55_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEGA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556476.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6546"/>
    <dbReference type="EnsemblBacteria" id="ABF92075">
        <property type="protein sequence ID" value="ABF92075"/>
        <property type="gene ID" value="MXAN_6546"/>
    </dbReference>
    <dbReference type="GeneID" id="41363751"/>
    <dbReference type="KEGG" id="mxa:MXAN_6546"/>
    <dbReference type="eggNOG" id="COG1615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686566_0_0_7"/>
    <dbReference type="OMA" id="LYGEVWI"/>
    <dbReference type="OrthoDB" id="1664309at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="3">
        <location>
            <begin position="167"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="37410" checksum="85BC5616A3DD792C" modified="2006-07-11" version="1">MKQKTWIAVIILGTLAANAVAYRVVRSRRDSAPEATPGAITHTPPTPPPTAPEEPPREDPNDGLARARRAAGLAALEDRDYDAAVSDFTEALRLRKDDQGDLVELLRIAAELRTREQARQQGEQARAQREPTPAPARSVQRTRPARGTARAQPRQESPSADEARGGLLLVTSTPPGLMVRVDGKPMDLTPARLPLRAGTYRVALAQGERTLAEETVALGEDDVRSLNRDLTAELAPAPRPAATAPASVEAPPPAAAPAATSPAATATRAESPPTAEPSVAPAAPTATGKGRLDVTSPGLYGEVWINNRPYGFPPLVAQGLPAGPARLEVRVNGVVKRKLTVDVVADQSTAVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI6</accession>
    <name>Q1CYI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator PhoP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP3</name>
        <name evidence="6" type="ORF">MXAN_6413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556345.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CYI6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6413"/>
    <dbReference type="EnsemblBacteria" id="ABF87903">
        <property type="protein sequence ID" value="ABF87903"/>
        <property type="gene ID" value="MXAN_6413"/>
    </dbReference>
    <dbReference type="GeneID" id="41363623"/>
    <dbReference type="KEGG" id="mxa:MXAN_6413"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_7"/>
    <dbReference type="OMA" id="FIINVRG"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="26189" checksum="689C31D6F78C1F55" modified="2006-07-11" version="1">MTSSVPALLLVEDDTNLRLALRDNLENQGGYAVEEATCVREAREHLGRRDFQLILLDVMLPDGDGYTLCRALREEGVATPVLMLTARTLEDDVVRGFESGAQDYLGKPYRLRELLARVGALVRRSGAAPVKGLRFAGYRMDLDRRKVESPAGAPVELTRTEFDLLAFLVRERERVLRRDEILDAVWGRDVVVDPHTVDNFVSSLKKKLGWNSTSRFAIQTVRGVGYRMEIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYN3</accession>
    <name>Q1CYN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556298.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6366"/>
    <dbReference type="EnsemblBacteria" id="ABF87212">
        <property type="protein sequence ID" value="ABF87212"/>
        <property type="gene ID" value="MXAN_6366"/>
    </dbReference>
    <dbReference type="GeneID" id="41363579"/>
    <dbReference type="KEGG" id="mxa:MXAN_6366"/>
    <dbReference type="HOGENOM" id="CLU_114513_0_0_7"/>
    <dbReference type="OMA" id="VEAGHYF"/>
    <dbReference type="OrthoDB" id="1348094at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187745" evidence="1">
        <location>
            <begin position="38"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22027" checksum="6FBB116F9B35023C" modified="2006-07-11" version="1">MTMATSSTRRQRTFLLGRHGAALTCALGLGAATPALADGSDTPHRFGLMLDAGAPHGVGLSAVLRPLPWLRLQAGPTTNTLSFGLRGGLSILPMQTFLAPSFNVEAGHYFGSDYNDVVDWLGATPSRASAAIRDVTYNYVTGSVGLEVGAASRFNFFLHLGLSYVDLGVDDASALLQDATDDPDVTARNLSVRATMPSVKLGFILYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYR2</accession>
    <name>Q1CYR2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556269.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6336"/>
    <dbReference type="EnsemblBacteria" id="ABF92635">
        <property type="protein sequence ID" value="ABF92635"/>
        <property type="gene ID" value="MXAN_6336"/>
    </dbReference>
    <dbReference type="GeneID" id="41363551"/>
    <dbReference type="KEGG" id="mxa:MXAN_6336"/>
    <dbReference type="eggNOG" id="COG5530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089301_0_0_7"/>
    <dbReference type="OMA" id="TTNWAVV"/>
    <dbReference type="OrthoDB" id="1143167at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014470">
        <property type="entry name" value="UCP01500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10028">
        <property type="entry name" value="DUF2270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="29856" checksum="E0116F488B77F58E" modified="2006-07-11" version="1">MPVRERDRTDVLESPWLSQQAMAQLFRGELSRSDTWRTRLDTTTNWAITTTAAVISFGFASTQSSHVTFLVGIWMVVSFLLIEARRYRYYDLWNRRVRLLEEGWWAPMLRHEPMDPDALRELALELERPQIQLSLFSAISTRLNRAYGPILMVLMMTWFVKVYSHPKPPVDLDEFLARAGVAWIPGEAVTAILLLLTLTASYLFLSSFFIRAPLGELRTRPRGRRAALWESFYRPYAIHTRRKPTRRPRPSSTSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYY8</accession>
    <name>Q1CYY8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6256"/>
    <dbReference type="EnsemblBacteria" id="ABF87536">
        <property type="protein sequence ID" value="ABF87536"/>
        <property type="gene ID" value="MXAN_6256"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6256"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432341_0_0_7"/>
    <dbReference type="OMA" id="ARWCFLN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="179" mass="20581" checksum="79D20C16DEDBB00C" modified="2006-07-11" version="1">MAGTRSEERDALRRTAILDAALECFLRFGYAKTSLDDIAKRANLSRPLLYLKFKNKEDIFAAVFESLFEARYPRVEQVLARPGAAGDKLLQVYEIILLEPWELMAGAPMASEFYTACERLLPEVEARHRRRWLKYTQAVLESRPLAEVFMLAVDGLQSDLPTTRVLRQRLELLVERFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ30</accession>
    <name>Q1CZ30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556156.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6212"/>
    <dbReference type="EnsemblBacteria" id="ABF89093">
        <property type="protein sequence ID" value="ABF89093"/>
        <property type="gene ID" value="MXAN_6212"/>
    </dbReference>
    <dbReference type="GeneID" id="41363440"/>
    <dbReference type="KEGG" id="mxa:MXAN_6212"/>
    <dbReference type="HOGENOM" id="CLU_2465808_0_0_7"/>
    <dbReference type="OMA" id="MNLIEPC"/>
    <dbReference type="OrthoDB" id="2220894at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="88" mass="9280" checksum="736A85A7A0666A6C" modified="2006-07-11" version="1">MNLIEPCVLAGAVVGTLTGAVLGFPHGLLWGLGGMAAGFVGGVLVLPFVILFLVMAGMALFFWPRHLLRQLRGTQPGTDDASREHGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ34</accession>
    <name>Q1CZ34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556152.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6208"/>
    <dbReference type="EnsemblBacteria" id="ABF87243">
        <property type="protein sequence ID" value="ABF87243"/>
        <property type="gene ID" value="MXAN_6208"/>
    </dbReference>
    <dbReference type="GeneID" id="41363436"/>
    <dbReference type="KEGG" id="mxa:MXAN_6208"/>
    <dbReference type="HOGENOM" id="CLU_1729426_0_0_7"/>
    <dbReference type="OMA" id="WFVDETQ"/>
    <dbReference type="OrthoDB" id="1776681at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="17077" checksum="A0F10424A7C63FD2" modified="2006-07-11" version="1">MGDLFQLFAVSAVVMGVSQTLSRERIFAPLRARLGGKDSWLGYLVSCPYCVSHYVAFVLVPLTGTNVIRVSVGGWPGYVLSWVLSTLLITVISAFFRVVFWFVDETQGLVKRRQRTEEEETATMRLHREQAEQTLNHHDPETREPSPPVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ64</accession>
    <name>Q1CZ64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6178"/>
    <dbReference type="TCDB" id="2.A.6.3.7">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87103">
        <property type="protein sequence ID" value="ABF87103"/>
        <property type="gene ID" value="MXAN_6178"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6178"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_7"/>
    <dbReference type="OMA" id="GQLMAIH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="40411" checksum="A5A01CFC1FE95F2E" modified="2006-07-11" version="1">MPWKQPEMRTRANRWCILLTLGGLASVSGCRTAEPSMEATVPTARAATETFRVEASRLASNLRLPAELVADQTVDVYAKVNSYVKHLRVDIGDVVKKGDLLVTLEAPEIEAQLASARARWAAMEALHVASKASYERTVRTSATEGAVAHDAVDQARAKEQADAAQVVAAKAHYDELLAMRSYLVMRAPFDGVVTERNVELGTYVGPSGRGSHKPMLVVRAVQKLRLHVSIPEAYSPYVHLDETVKFTVRSLPGREFSARITRRARALDAELRAERIEADVDNPDGALLPLMVADASIALSSQGPTIMIPRTALVESGMGTYVLRVQDGAAKRVPVSRGMRAGEKVEVFGAIETGDVLVLKASEEMKDGMAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZK3</accession>
    <name>Q1CZK3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sucA</name>
        <name evidence="9" type="ORF">MXAN_6035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555984.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6035"/>
    <dbReference type="EnsemblBacteria" id="ABF87084">
        <property type="protein sequence ID" value="ABF87084"/>
        <property type="gene ID" value="MXAN_6035"/>
    </dbReference>
    <dbReference type="GeneID" id="41363273"/>
    <dbReference type="KEGG" id="mxa:MXAN_6035"/>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_7"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="29166at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="8">
        <location>
            <begin position="612"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="963" mass="107057" checksum="CBCDFD2C0EF93580" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D063</accession>
    <name>YQGF_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_5823</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YqgF nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555774.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D063"/>
    <dbReference type="SMR" id="Q1D063"/>
    <dbReference type="STRING" id="246197.MXAN_5823"/>
    <dbReference type="EnsemblBacteria" id="ABF87174">
        <property type="protein sequence ID" value="ABF87174"/>
        <property type="gene ID" value="MXAN_5823"/>
    </dbReference>
    <dbReference type="GeneID" id="41363063"/>
    <dbReference type="KEGG" id="mxa:MXAN_5823"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_0_7"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000257553" description="Putative pre-16S rRNA nuclease">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <sequence length="151" mass="16308" checksum="1A0CF196F5A8C7C2" modified="2006-07-11" version="1">MRTMGLDLGTKTIGVAVSDGLGLTAQGITTVRRTSLKADLAALATVASEHEVTHVVLGLPLNMDGSEGPRAEASRKFADTLAQSLGVTVELWDERLSTVAATRTLLEADVSRARRREVIDQVAAQFILQGWLDAHRPPDTDYHPDDYDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0P5</accession>
    <name>Q1D0P5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555593.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5639"/>
    <dbReference type="EnsemblBacteria" id="ABF86278">
        <property type="protein sequence ID" value="ABF86278"/>
        <property type="gene ID" value="MXAN_5639"/>
    </dbReference>
    <dbReference type="GeneID" id="41362885"/>
    <dbReference type="KEGG" id="mxa:MXAN_5639"/>
    <dbReference type="eggNOG" id="ENOG5032SHK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129221_0_0_7"/>
    <dbReference type="OMA" id="WSGLKFV"/>
    <dbReference type="OrthoDB" id="1595974at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="15997" checksum="ED72B27F14BB658F" modified="2006-07-11" version="1">MTPYALASLPAMLGIRAGSKVSVINPPRGFVQKLNPLPDGVEFLITAVTGLDVILFFTEDPQELVQRLPALARAMALTGGIWVCWPGGEGARRDLSEDFVRHAALDIGLVDNKICIIDATWTGLRLVRRPRGRPDKPGERKRATAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q7</accession>
    <name>Q1D0Q7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555581.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5627"/>
    <dbReference type="EnsemblBacteria" id="ABF91425">
        <property type="protein sequence ID" value="ABF91425"/>
        <property type="gene ID" value="MXAN_5627"/>
    </dbReference>
    <dbReference type="GeneID" id="41362873"/>
    <dbReference type="KEGG" id="mxa:MXAN_5627"/>
    <dbReference type="HOGENOM" id="CLU_969184_0_0_7"/>
    <dbReference type="OMA" id="HERAGDY"/>
    <dbReference type="OrthoDB" id="883348at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188120" evidence="1">
        <location>
            <begin position="18"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="30893" checksum="36178DAC9BE21D14" modified="2006-07-11" version="1">MRIPLHAFIAAMLVASACGGEAPSSADSSPDEALASREQAAFSGVNGTYCLVSPYNCKLQASGGNRVPTNSPEDDNWGLVTGVPIRDGHGTVVGTNTRTSAAFNYGQTRTFAGEKHAFAVSTSNSSAGWLPISSILGRTSFEQKVGHVSALGAGLGNLGCYAVRDWHDTTLEFKKVVYDSTATHERAGDYLPLVRANGLRSANLVFNVPGFALGGPAVDHFPAGTKFQRLDVPTEHGVPSIDIPLWVQDSAGRYRQQSGTMKFLYGYVIAATGTKRNGWMAYDALQVSSGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D101</accession>
    <name>Q1D101_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">MXAN_5529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555487.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5529"/>
    <dbReference type="EnsemblBacteria" id="ABF92008">
        <property type="protein sequence ID" value="ABF92008"/>
        <property type="gene ID" value="MXAN_5529"/>
    </dbReference>
    <dbReference type="GeneID" id="41362782"/>
    <dbReference type="KEGG" id="mxa:MXAN_5529"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_4_7"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="155"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="22166" checksum="D368D1D475340B2D" modified="2006-07-11" version="1">MPTLVLVRHGQSLWNQENRFTGLVDVPLTDQGRQEARRAAEALSGMTFDVAYTSALIRAQETLSILLDALGQQVPTIRDAALNERNYGDLQGLNKADAAKRWGAAQIKEWRRSFDVPPPNGESLEMTAERVLPFYERAIAGDLRLGKNVLVVAHGNSNRSLVMKLDNLTGEQVVGLELATGVPLIYEMSPDGEVLSKRTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B1</accession>
    <name>Q1D1B1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89960">
        <property type="protein sequence ID" value="ABF89960"/>
        <property type="gene ID" value="MXAN_5415"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5415"/>
    <dbReference type="HOGENOM" id="CLU_2807941_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="67" mass="7715" checksum="80629C1DCC49E2C4" modified="2006-07-11" version="1">METTGTGVAMSRGEPSTSEYQYNYTYVAPLALAQEVSLSHRPTLEWWGQTMEHLPHIVNNRPHWVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B9</accession>
    <name>Q1D1B9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choloylglycine hydrolase family protein</fullName>
            <ecNumber evidence="4">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555369.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5407"/>
    <dbReference type="MEROPS" id="C59.001"/>
    <dbReference type="EnsemblBacteria" id="ABF87264">
        <property type="protein sequence ID" value="ABF87264"/>
        <property type="gene ID" value="MXAN_5407"/>
    </dbReference>
    <dbReference type="GeneID" id="41362670"/>
    <dbReference type="KEGG" id="mxa:MXAN_5407"/>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045206_1_2_7"/>
    <dbReference type="OMA" id="MCTRLVY"/>
    <dbReference type="OrthoDB" id="636485at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="38680" checksum="DF9285418785BDE1" modified="2006-07-11" version="1">MCTDFLVATEDSSAVVVGRSMEFGIDLGSKFRFHAKGHTVQSPGSLTHLHGLKWTTKFDYVGLTVTLYGVTVIGDAMNSEGLSAGALWMPTSTYPQAAKDPSRGLAPELFVEWAVGNFATVDAVKEALANGDAELWHSDWMSSKIPLHFALHDAKGNSMVVEFTDRQMFLYASTGHDNSPLNMHNPVAVLTNHPTFPDHLENLKNYARLSSRGATPVKLGTGTFAPHGCGSGLFGIPGDSTPPSRFVRAVYLREFSEKPKNAAEARSLALHLLNTVDIPYGTSRDLNEATGKDSLDYTQWVVVKDLTNRTFGVRTYDSLGLQTLDLRTVDFKKADGKTLAVSPVDSQLDANKQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1M2</accession>
    <name>Q1D1M2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555266.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5300"/>
    <dbReference type="EnsemblBacteria" id="ABF91206">
        <property type="protein sequence ID" value="ABF91206"/>
        <property type="gene ID" value="MXAN_5300"/>
    </dbReference>
    <dbReference type="GeneID" id="41362571"/>
    <dbReference type="KEGG" id="mxa:MXAN_5300"/>
    <dbReference type="HOGENOM" id="CLU_1053047_0_0_7"/>
    <dbReference type="OMA" id="SHAFANR"/>
    <dbReference type="OrthoDB" id="2188558at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="24588" checksum="FFA25FDA2217B634" modified="2006-07-11" version="1">MADTAFCYFMGFRIGMPLDGYVHMNLSALRVRALAGLVSAPMLAHAQEEPTVAPHSAPPAVHGGTQRLSSAAALGVHSLSVDSVSPASMAFIVDIEQPLSPFISVFAGGHVGVNLKATGLQAGGRVYLTGRPFQGPFLSVQGDGTFFDADDDVSKLRASVSGLVGYSQQLGNQWHIALAGGAGFSHLRQETELPRSATCTLFSWCLLSTPERTVETTQTLHPVVRLTAVHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D250</accession>
    <name>Q1D250_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555093.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5119"/>
    <dbReference type="EnsemblBacteria" id="ABF91563">
        <property type="protein sequence ID" value="ABF91563"/>
        <property type="gene ID" value="MXAN_5119"/>
    </dbReference>
    <dbReference type="GeneID" id="41362403"/>
    <dbReference type="KEGG" id="mxa:MXAN_5119"/>
    <dbReference type="eggNOG" id="ENOG5032MHP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709456_0_0_7"/>
    <dbReference type="OMA" id="GMHGLEY"/>
    <dbReference type="OrthoDB" id="569450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="41514" checksum="AA3627DAB3D57686" modified="2006-07-11" version="1">MTPLSPAVNSPSPVTAPSPGGALAFRGLWLFSPRADALIVALPLALALCTAAANVWLAPGAAEGAHRLSAWTAQNLLGNATHVILTFLLFAVHRDVLTSAPGQPRQVLAGSLGMLAVGTVLFFTFYAERTAHTYGVAVIFNVFGTHHTLSQHRGIWSLHGLRAGKAGLPGASALERKLQQMYVPLLLSLLLVRIFFVPEAPGPDAPAYLDIGQGAVLPHGTLGVLLAVWLGYFMLLFRTVLRAEAVSGPKVLYLLAMATATGLVLVAPTWGYVMLPGMHGLEYYMLTARMLEPREGDTPRLPRKFIVPAMIASMLPLLALGAVHGLLQQGVVRGALGSNMGVAETHPLLRAMTSLGFAVVLAHYFADALIYRFRIPSIRAVMLKRLGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D278</accession>
    <name>Q1D278_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5091"/>
    <dbReference type="EnsemblBacteria" id="ABF91423">
        <property type="protein sequence ID" value="ABF91423"/>
        <property type="gene ID" value="MXAN_5091"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5091"/>
    <dbReference type="HOGENOM" id="CLU_110261_0_0_7"/>
    <dbReference type="OMA" id="GAHWYAA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="239" mass="26069" checksum="00A1ABD0EC9C5E77" modified="2006-07-11" version="1">MARRFRLSGIVWTPGNYLLFKVPELPAGMMPGIGGAQSPGGLKLKAHGGYLLRLESFGGLELLRLAREALALDGAMGATGLKVSVNRRRKVVRLAYVAPFTEGRQGAHWYAAHHALPRLLSRATNAAVQAYVYDPDEGEQVIAYGNGRRVGGERVVYEDVELPVPLDQMDDAAFKHMQERWPVGHLAYVFGLTRKELLRLPRVAPGHELALEGRDAEGAAVLEALLPTCQVTLPESDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D1</accession>
    <name>Q1D2D1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555013.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92041">
        <property type="protein sequence ID" value="ABF92041"/>
        <property type="gene ID" value="MXAN_5037"/>
    </dbReference>
    <dbReference type="GeneID" id="41362322"/>
    <dbReference type="KEGG" id="mxa:MXAN_5037"/>
    <dbReference type="HOGENOM" id="CLU_2116881_0_0_7"/>
    <dbReference type="OMA" id="DILACHA"/>
    <dbReference type="OrthoDB" id="1708963at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="114" mass="13213" checksum="BDBB3425A15A41F7" modified="2006-07-11" version="1">MDPFVRRLVERLHDPSKPLSRNRHFHTFETPEGRAALKVVRRLRSLQKDILACHAEGFRARIFRHATGKGEHRIELLMERLSGRRVSMLQSDEFELLTALPGVRDALEVFDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2K4</accession>
    <name>Q1D2K4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="11" type="ORF">MXAN_4963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554941.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4963"/>
    <dbReference type="EnsemblBacteria" id="ABF91330">
        <property type="protein sequence ID" value="ABF91330"/>
        <property type="gene ID" value="MXAN_4963"/>
    </dbReference>
    <dbReference type="GeneID" id="41362248"/>
    <dbReference type="KEGG" id="mxa:MXAN_4963"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_7"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="10">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="56219" checksum="A779C6117A035171" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R1</accession>
    <name>Q1D2R1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative polyglutamate synthase CapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554886.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4905"/>
    <dbReference type="EnsemblBacteria" id="ABF89868">
        <property type="protein sequence ID" value="ABF89868"/>
        <property type="gene ID" value="MXAN_4905"/>
    </dbReference>
    <dbReference type="GeneID" id="41362194"/>
    <dbReference type="KEGG" id="mxa:MXAN_4905"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_2_2_7"/>
    <dbReference type="OMA" id="NFCFGGN"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="61"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="43574" checksum="AB7A0A861A472963" modified="2006-07-11" version="1">MRHVALLLLMLSACHPRTIPPPEPLPPEEPAGQSPAPGDAGQAPAPPIGAPAAEPPARSVSIIVGGDVTLGHNYQTHYDAETAKGRPQDALLAYGFQEVKPLTDAADLFVVNLECPFTERGEKLPKNFNFRAKPELVGILTAGGVDVVSLANNHLMDYGAQGLLDTLDTLDAAHIPYFGAGRNLAEARRPAIVTVGGQRVALLGYFFLGTRNIEPPGVYATETTPGVAGHFSDEAVMEQMLREDIAAARAQADIVLPYFHWGREGTYTPEPYQVRLAHVAIDAGAAGVLGAHPHVLQAMELYQGRPVVYSLGNFVFGGNWNPRDKRGALWKGHFGPDGGYLSSEILPLRTDRFPELPFQPVPVTGEAAEAVLRLLAESSEGVERMLPELEPWARPPPSPEVRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D367</accession>
    <name>Q1D367_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554731.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4744"/>
    <dbReference type="EnsemblBacteria" id="ABF86517">
        <property type="protein sequence ID" value="ABF86517"/>
        <property type="gene ID" value="MXAN_4744"/>
    </dbReference>
    <dbReference type="GeneID" id="41362043"/>
    <dbReference type="KEGG" id="mxa:MXAN_4744"/>
    <dbReference type="HOGENOM" id="CLU_1364987_0_0_7"/>
    <dbReference type="OMA" id="HPSVMVP"/>
    <dbReference type="OrthoDB" id="1766277at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="20894" checksum="271E148FC3E82358" modified="2006-07-11" version="1">MPAEVLVMCGACGRPQPAGRPRCIACEAVLPEAPLPGGPAPGEPFFVADLGGGRMLSGQGTRLFYQPHPSVMVPPVELDSLREARLESRYFREALALTVFALLGLWAQPVALKVLGLGMAALGGLLALTCRSHGLVLVPRQGAQVRWPLGLARRGSPRDTRLLAAWTSLSEALRVRGVAVDGESSPLPPPPTQDGGPLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D393</accession>
    <name>LPXB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="1">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxB</name>
        <name type="ordered locus">MXAN_4718</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxB family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554705.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D393"/>
    <dbReference type="SMR" id="Q1D393"/>
    <dbReference type="STRING" id="246197.MXAN_4718"/>
    <dbReference type="CAZy" id="GT19">
        <property type="family name" value="Glycosyltransferase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90745">
        <property type="protein sequence ID" value="ABF90745"/>
        <property type="gene ID" value="MXAN_4718"/>
    </dbReference>
    <dbReference type="GeneID" id="41362017"/>
    <dbReference type="KEGG" id="mxa:MXAN_4718"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036577_3_0_7"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00392">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000255199" description="Lipid-A-disaccharide synthase">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00392"/>
        </source>
    </evidence>
    <sequence length="383" mass="41692" checksum="5E6B9BC19CBAEDA3" modified="2006-07-11" version="1">MTNPPRILVVAGEASGDTHAAELVAALRARRPDLTFFGMGGARLAAQGVELLFDAREVSVMGITEVLPRIPRILQILKGLAEAAAERKPDVAILVDIPDFNLRLAKKLKALGVPVAYYVSPMIWAWRRGRVRTIKRLVDRMLCILPFEEDFYREAGVSARYVGSPVVEQVPSPDTATAFRERLGLSKDAPTLALLPGSRMGEIRRLLPDMVEAAKRLSAERPGLQVVVPLAPTIDREEITSRFEGSGVTPILVEGRAPEVVGASDAAVVASGTAVLEAGLMQRPLVVVYRVSLITYWVGRLMLKVAFVSLINLLAGRRVVPELLQGEMTPERIAEEVRRVWIPGAPREEMLQGLAEMRGRLGETGAATRAAESVLELLPPGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D3</accession>
    <name>Q1D3D3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4674"/>
    <dbReference type="EnsemblBacteria" id="ABF89233">
        <property type="protein sequence ID" value="ABF89233"/>
        <property type="gene ID" value="MXAN_4674"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4674"/>
    <dbReference type="eggNOG" id="COG3804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050509_1_1_7"/>
    <dbReference type="OMA" id="WGFGAMG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="137"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="33783" checksum="C86421F082243669" modified="2006-07-11" version="1">MPVVVMGLGFIGQEIARAAMSSPEVELIGAVDVQSGLVGRPLGDVLGSPAPRVKVSASLAQAVGKRKGVVVLHATGSRLPKVFDQVMEAVKLGLPVASTCEELAFPYLKYPELADELDQAAQKAGVAVVGTGVNPGFVLDRLVAVAGQVCGPVRRATVTRVVDARTRRPSLQRIVGAGLSEEEFFELVDSEQLGHVGLVESAALAALGLGLDCDDFEEEVAPVFAEEDISGGAFPVRKGRVAGMFQSVVGLEDGQERVRLELTIAMGADDPKDRIEIDADPKLVLEIPGGVAGDRATANALVNAAPRLTAAEAGLLTVLELPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3I6</accession>
    <name>Q1D3I6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554614.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4619"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90679">
        <property type="protein sequence ID" value="ABF90679"/>
        <property type="gene ID" value="MXAN_4619"/>
    </dbReference>
    <dbReference type="GeneID" id="41361919"/>
    <dbReference type="KEGG" id="mxa:MXAN_4619"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021683_0_0_7"/>
    <dbReference type="OMA" id="VTDELYP"/>
    <dbReference type="OrthoDB" id="241492at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="417"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="780" mass="86820" checksum="7107B5B3A3D2A1F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3J1</accession>
    <name>Q1D3J1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554609.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4614"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88221">
        <property type="protein sequence ID" value="ABF88221"/>
        <property type="gene ID" value="MXAN_4614"/>
    </dbReference>
    <dbReference type="GeneID" id="41361914"/>
    <dbReference type="KEGG" id="mxa:MXAN_4614"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496701_0_0_7"/>
    <dbReference type="OMA" id="PETMGGA"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="546" mass="58739" checksum="B084A6BA27367C97" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3P5</accession>
    <name>Q1D3P5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4560"/>
    <dbReference type="EnsemblBacteria" id="ABF89031">
        <property type="protein sequence ID" value="ABF89031"/>
        <property type="gene ID" value="MXAN_4560"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4560"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914750_0_0_7"/>
    <dbReference type="OMA" id="DAQKHFK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="35219" checksum="816A60C54519598C" modified="2006-07-11" version="1">MEGTPAESARPGRARRGRARGRHRGGDPMKTSPRFLLAGLVLACTLTASSALAAPKKATLGVFLATTLADGQERFEYAEALAARLTETLDTPVAAKSFGRYEDFSRAVAGGMVDFAVVDAWAAVQLGAKAKPVAWASRAGDTQQRWAIVALQRGVVKDLAGKRLAHVKGAGPADPKFVTHVVLGGDLDAQKHFKLAPVPNVESALKMLEAKGAEAALVPLAHVPKGKDVRVLFRSGRVPGAVLVDLRNHEAALTGALGKVGAVAPFDAFARLQDKDFDEFSKLVTRGPPRRQPVLAEGAELHVEAEVLVRSEELGPALPSFVGDLAVSAEQPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3R1</accession>
    <name>Q1D3R1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554539.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4544"/>
    <dbReference type="EnsemblBacteria" id="ABF86459">
        <property type="protein sequence ID" value="ABF86459"/>
        <property type="gene ID" value="MXAN_4544"/>
    </dbReference>
    <dbReference type="GeneID" id="41361845"/>
    <dbReference type="KEGG" id="mxa:MXAN_4544"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_1_7"/>
    <dbReference type="OMA" id="YFTTNVV"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="172"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="489" mass="56070" checksum="46FF94725F4AF807" modified="2006-07-11" version="1">MLLAAPWPRRLVLEPRHRMRIAVIATYTHPTRLRLKEPSIMQSSVPELIAGLCPPHVEVEIFNEKERDIPMDRHWDLVFFSYLHSFYEHTKVLSTLFRQRGMTTVAGGRHASYFPDDAQQYFDAVITGEPEANVPALIEDFEKGQLQPRYQRPPLGPAAIRPYRYDLIDFTHNKLRLPGIEASRGCPFSCNFCVLTGNERYRYRPVAHVIDEIQQHMHWNPNFMGLMDDAFVFLDNNLGGSPKYLRELCEALIPLKKTWGCALTFNVLKDESLVKLMAKAGCRYVYTGLESLNPDSIKAMNKGQNKLSEVDAVIRRVFSAGILLSFGLIVGSDGDTNAYLEKLPEYLSDLQYFSVTFLGIVCPYPETPFFRELQAENRLLPGTLSRDYDGYTLCHRPKSLDTSEVVEHFHRLCAQLGSLPNIARHYWSKLTMSDMPRYKQTILFSGPEIVSIRNPVKNTARRYIAGQDALEYWDTQQMAQLGLQPQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z0</accession>
    <name>Q1D3Z0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CheW-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554460.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4462"/>
    <dbReference type="EnsemblBacteria" id="ABF92129">
        <property type="protein sequence ID" value="ABF92129"/>
        <property type="gene ID" value="MXAN_4462"/>
    </dbReference>
    <dbReference type="GeneID" id="41361772"/>
    <dbReference type="KEGG" id="mxa:MXAN_4462"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026105_0_0_7"/>
    <dbReference type="OMA" id="VAGIFPH"/>
    <dbReference type="OrthoDB" id="1042858at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="28590" checksum="A0FBD9D2EA18018E" modified="2006-07-11" version="1">MSPFESGRRLCLLVEAGETRYAVEATSVMEVAMPGANGSSLRGVLEVKDLCALLGGPPEEGPGMVVVLDVSPTLAVRVRSVVEVADVARAPFFLLPPGLADSLAPLSRGAVLHKSRLYLELIAEALPHRVGSMSPAVAARPVHWAEAAPDRALVFESQSRLFGVPLGLVSQVISRGEAFCVLPVPSGPVAGIFPHDQVLWPVCSVPALLGEAPVPESFIVLTELAGRNVGLTATRVLGVMQRFEPDDTAGSFRAPGLSEPVAFLDLQRMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D460</accession>
    <name>Q1D460_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554391.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4390"/>
    <dbReference type="EnsemblBacteria" id="ABF87354">
        <property type="protein sequence ID" value="ABF87354"/>
        <property type="gene ID" value="MXAN_4390"/>
    </dbReference>
    <dbReference type="GeneID" id="41361700"/>
    <dbReference type="KEGG" id="mxa:MXAN_4390"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_34_0_7"/>
    <dbReference type="OMA" id="GAIFKGH"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="21313" checksum="A66DB46BE5CB11CC" modified="2006-07-11" version="1">MIRKLLLGTLGLLMLGASVLTAAWMSLRATPAPQGRLLATSEAERYLLAAARAGETDIVAGLVQAGTPVEARDARGFSPLILAAYHGHADTVRALLSAGADACAGDNNGNTALMGAAFKGYADIVGLINQQPCAVDQSNRFGQTALMFASLFGRKEVVEQLRQQGASPDVRDGSGRSAQDWARTQEPNAPVPQAPTAPETSASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F5</accession>
    <name>Q1D4F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554296.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4293"/>
    <dbReference type="EnsemblBacteria" id="ABF92954">
        <property type="protein sequence ID" value="ABF92954"/>
        <property type="gene ID" value="MXAN_4293"/>
    </dbReference>
    <dbReference type="GeneID" id="41361604"/>
    <dbReference type="KEGG" id="mxa:MXAN_4293"/>
    <dbReference type="HOGENOM" id="CLU_1659683_0_0_7"/>
    <dbReference type="OMA" id="ELQHIDA"/>
    <dbReference type="OrthoDB" id="1936689at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="157" mass="16389" checksum="6191946BF922BE00" modified="2006-07-11" version="1">MMSTQDDRYPQGSFGASPEYGARFAELTNALIPGGRGLVQQLFRAKQEALKGVAQILDAQIHELQHIDAAIEDRAKQAHTAPAAGQPNRSGVSFGDVLQKAGDLILAKRPKGTTGSEAGARPSDRRAPPESATSPDSSSPASASSSAPEPLEKISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4K3</accession>
    <name>Q1D4K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554248.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D4K3">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4245"/>
    <dbReference type="EnsemblBacteria" id="ABF92156">
        <property type="protein sequence ID" value="ABF92156"/>
        <property type="gene ID" value="MXAN_4245"/>
    </dbReference>
    <dbReference type="GeneID" id="41361561"/>
    <dbReference type="KEGG" id="mxa:MXAN_4245"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096477_0_0_7"/>
    <dbReference type="OMA" id="PFCALVD"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="121"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="25424" checksum="DF1DB8ADCD5F8B84" modified="2006-07-11" version="1">MRQYLLLDDNVAFAENLAEILRDGGDAATVVTSGDEAVRLARTTRFDVLLTDMRMPGMSGADAVHHLRRVDPGLAAVVITAHPRQDDLETARREGLLAVLPKPVPIPTLVELLSGARRDGLVVLVEDDPALSDNIAELLRGRGFSCVTAASVLDADRILCVQPFAALVDLRVPGGPDGEALRRLRARYPHLPTFVMTAYPDAAPLDGTTGVFSKPFDPGALMEVLETAHAARPTHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4K9</accession>
    <name>Q1D4K9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554242.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4239"/>
    <dbReference type="EnsemblBacteria" id="ABF93054">
        <property type="protein sequence ID" value="ABF93054"/>
        <property type="gene ID" value="MXAN_4239"/>
    </dbReference>
    <dbReference type="GeneID" id="41361555"/>
    <dbReference type="KEGG" id="mxa:MXAN_4239"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113637_0_0_7"/>
    <dbReference type="OMA" id="YETRLYW"/>
    <dbReference type="OrthoDB" id="1984062at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17718" checksum="93A1CF1411B5632D" modified="2006-07-11" version="1">MTNVTITEYETRLYWQGERGAVLTSDRAPPVPIGQPLTGQDTVAVGPWSPEALLVGAVEGRTLLAFLEQAREADVRVLFYQSSAVARVVCGADQPPHLTDLIVRPHVAVATEADAEAVRLIFTELPAHCFPSSVINITPRIEPVVETWHARSSGRSVPAATAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D510</accession>
    <name>Q1D510_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554092.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D510"/>
    <dbReference type="STRING" id="246197.MXAN_4085"/>
    <dbReference type="EnsemblBacteria" id="ABF86732">
        <property type="protein sequence ID" value="ABF86732"/>
        <property type="gene ID" value="MXAN_4085"/>
    </dbReference>
    <dbReference type="GeneID" id="41361414"/>
    <dbReference type="KEGG" id="mxa:MXAN_4085"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_7_2_7"/>
    <dbReference type="OMA" id="LAVAPCN"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="22942" checksum="F140FE3C8462A1FE" modified="2006-07-11" version="1">MASGILHNECVPAALQDSRGAGGKAAWAHPWPLSHAAAPGQASPSREADSRFTHPFEVVMLRSLLVPMLLAVSLLGCGDDESVNPDSGDPTKVTYAESLNVDLAEMTRLESGLYIQDTFVVEDGAQAEAGKRVQVRYTGYLPDGRSFDATGNGPAIGFTLGVGQVIAGWDEGIAGMRVGSRRRLIIPSSLGYGATGSGRRIPPYTVLIFDTELVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D584</accession>
    <name>Q1D584_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89161">
        <property type="protein sequence ID" value="ABF89161"/>
        <property type="gene ID" value="MXAN_4009"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4009"/>
    <dbReference type="HOGENOM" id="CLU_1213763_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="228" mass="23356" checksum="3EA6C307662BA175" modified="2006-07-11" version="1">MLSPERHRPLVAPQDTGAAPGHWRVTVQDSACPASPSRISSSPGSPTLHAASATAANTTPQYLDPSKWICIAGTLVAAAPRHPSWEAATRWRIGIPTRYSCSVSDTPTESSQRMSGFIAGAAIAQSLMVPYLVLAGLMAAEVSGALAAALLLYGLTLAVATVFLFRRKRWAWSLSSALAVVAFLAGAGVAWMPPSWVGGIHALGAAAILGALSAGRPAIAAPPALTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A0</accession>
    <name>Q1D5A0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lon protease</fullName>
            <ecNumber evidence="6 7">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 16" type="primary">lon</name>
        <name evidence="16" type="ORF">MXAN_3993</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554003.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D5A0"/>
    <dbReference type="STRING" id="246197.MXAN_3993"/>
    <dbReference type="EnsemblBacteria" id="ABF92887">
        <property type="protein sequence ID" value="ABF92887"/>
        <property type="gene ID" value="MXAN_3993"/>
    </dbReference>
    <dbReference type="GeneID" id="41361325"/>
    <dbReference type="KEGG" id="mxa:MXAN_3993"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_7"/>
    <dbReference type="OMA" id="MVNIEDK"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="615"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="799"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF92887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="827" mass="90438" checksum="558E918A4A965126" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Q7</accession>
    <name>Q1D5Q7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_3834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3834"/>
    <dbReference type="EnsemblBacteria" id="ABF88976">
        <property type="protein sequence ID" value="ABF88976"/>
        <property type="gene ID" value="MXAN_3834"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3834"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_7"/>
    <dbReference type="OMA" id="IAMFIDV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF88976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="419" mass="44834" checksum="32565D05710379A4" modified="2006-07-11" version="1">MCRAVALAIFLFTYVFIAGARLPYLKLDRPGGALLGAVLMVVFGVVTPAEVFNHSADANRHAIDADTIVLLLGMMLLAAYMSQASFFRTAGAWAVRRAHTPRRLLLAVTFISAALSAFLVNDTVCLMLTPLVLATVEDARLPPAPYLLAVCMGSNSGSVATFTGNPQNMLIQGASGLSYASFAAYMALPALLSTAVVAAGLLYLFRHDLPVKQFEPNPPPPPVDRGLLVLTLTVLSGVVVAFFAGLPMSWSALAGAALVMALARREPREALERVDWVLLLFFASLFVVVYGVNKHGYAEDIRVLFEPLMAGPPLRETLGFAGLTLVASNLFSNVPFVMLARTWVPTLHDVELGWHVLALGSTLAGNLTLVGSVANLIVFEAARGKVNMSFLRFLRVGLPVTLVSFVVGLSVLLVEHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D625</accession>
    <name>Q1D625_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553729.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3712"/>
    <dbReference type="EnsemblBacteria" id="ABF87236">
        <property type="protein sequence ID" value="ABF87236"/>
        <property type="gene ID" value="MXAN_3712"/>
    </dbReference>
    <dbReference type="GeneID" id="41361045"/>
    <dbReference type="KEGG" id="mxa:MXAN_3712"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_1_7"/>
    <dbReference type="OMA" id="YDVGSRH"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="37"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="189"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="49160" checksum="981F4A270C38D8DB" modified="2006-07-11" version="1">MSKASPSKVPTRVADPALESLFDVHEATLPNGLQVRLLANHQAPVVSLYTVFQVGSRNERPGITGISHLFEHMMFNGAKKYGPKMFDKTLESNGGRSNAYTSTDLTVYYDDFSADALETVLDLESDRMRSLRISQQTLTSEREVVKEERRVRVDNDIFGLMDEELGTLVYKAHPYRWPVIGWMADIEAIRREDCQDYFRTYYAPNNAVLYIVGAIDPKKTLALVRKYYGSIPKGPAPAAVLNSEPEQKGERRAEVRHPAQSPALMLGFRGPASRDDDTFVLDVIQYVLTKGEGSRLIRSLVYEQKLAVSLMLDWSWRIDPGTILFYLALKPDSDPKKVEAALYAELEKIAREGITERELQKAQNNLRSDHLRELATNSGRAHALGHYEALLGDWRRLLTLPSTYTSITNDQVKAVAAKYFAPEHRSVVTLVPAPTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6M6</accession>
    <name>Q1D6M6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553533.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3503"/>
    <dbReference type="EnsemblBacteria" id="ABF91470">
        <property type="protein sequence ID" value="ABF91470"/>
        <property type="gene ID" value="MXAN_3503"/>
    </dbReference>
    <dbReference type="GeneID" id="41360848"/>
    <dbReference type="KEGG" id="mxa:MXAN_3503"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_2_7"/>
    <dbReference type="OMA" id="ELIWAHT"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="120" mass="13781" checksum="B98E39D86A2A6574" modified="2006-07-11" version="1">MTTTKRVEKPWGYELIWAHTERYVGKLLHVKQGHKLSLQFHNRKDETIHVQSGKLLFVVDEGQGLIEKEMNPGESYHIKPLTKHRMVALTDCDILEVSTPELDDVVRLEDAYGRTGTSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6W4</accession>
    <name>Q1D6W4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thymidylate kinase</fullName>
            <ecNumber evidence="3 6">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tmk</name>
        <name evidence="8" type="ORF">MXAN_3412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553445.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3412"/>
    <dbReference type="EnsemblBacteria" id="ABF87381">
        <property type="protein sequence ID" value="ABF87381"/>
        <property type="gene ID" value="MXAN_3412"/>
    </dbReference>
    <dbReference type="GeneID" id="41360759"/>
    <dbReference type="KEGG" id="mxa:MXAN_3412"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_7"/>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="7">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="23571" checksum="B864602D620C63BE" modified="2006-07-11" version="1">MSAARKKAAARRPGRFIVLEGLDGAGTTTQVERLAAALRAEGHSVLTTREPSDGPVGTMIRQALTGRLGLPGGAGPLAPETLALLFAADRTDHLTARVLPALAAGQIVLCDRYVLSSLAYQGASLPMEWVEAVNACAVSPDLTLFVGVAPEVAARRRKARGGAAELFEADEAQRRIAKQYVAAIRRREKHERIVHIDGEQGIEAVTAASLVEIRKLLARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Y5</accession>
    <name>Q1D6Y5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aha1 domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553424.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3391"/>
    <dbReference type="EnsemblBacteria" id="ABF88378">
        <property type="protein sequence ID" value="ABF88378"/>
        <property type="gene ID" value="MXAN_3391"/>
    </dbReference>
    <dbReference type="GeneID" id="41360738"/>
    <dbReference type="KEGG" id="mxa:MXAN_3391"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_8_1_7"/>
    <dbReference type="OMA" id="MRWELEA"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="17325" checksum="5373320ECF82C809" modified="2006-07-11" version="1">MTNTTGPGKRIDTASRVIAASPGALYRAFVEPEAVATWLPPEGMKGHIHAFEPRAGGTYRMTLSYDNADHTAPGKTSAHEDVVEGLFVELVPNERIVQRFEFESDDPAYAGTMTMTWTLTPVAGGTRVTVTCEDVPEGIRQEDHIEGLTSTLANLAAYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D700</accession>
    <name>Q1D700_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3376"/>
    <dbReference type="EnsemblBacteria" id="ABF89690">
        <property type="protein sequence ID" value="ABF89690"/>
        <property type="gene ID" value="MXAN_3376"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3376"/>
    <dbReference type="HOGENOM" id="CLU_147977_1_0_7"/>
    <dbReference type="OMA" id="HRKKTDF"/>
    <dbReference type="OrthoDB" id="1885144at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188229" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10887" checksum="5A1727E1F0431BBE" modified="2006-07-11" version="1">MSMRRLVSAVVVLGLWAAPSVAMSQEPRDTVKIVQEEDRTVVRKKTVIDFTDVAVEGELTKPEGSYVLHRKKTDFQSLIKVRDNFDPELQKSVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D708</accession>
    <name>Q1D708_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553401.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3368"/>
    <dbReference type="EnsemblBacteria" id="ABF93136">
        <property type="protein sequence ID" value="ABF93136"/>
        <property type="gene ID" value="MXAN_3368"/>
    </dbReference>
    <dbReference type="GeneID" id="41360716"/>
    <dbReference type="KEGG" id="mxa:MXAN_3368"/>
    <dbReference type="HOGENOM" id="CLU_1085148_0_0_7"/>
    <dbReference type="OMA" id="CPRSMDR"/>
    <dbReference type="OrthoDB" id="982913at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="29084" checksum="DF61A662666FA0D5" modified="2006-07-11" version="1">MAKESYNDLIFQLGDLARDRLPGKPTCPRSMDRVYRAEEAVVARRDELAALEQEMNDEDAAYSDFLAEQGEERAKHAVIVKKWKKAVDAIDGKVKELRKTLASRKAEQRYAEDGLVKLEKKISDMELTGEPPDKIELARGNLKKNRLQQMRLGRQLEDLESNLATALTPLPGQPGAAGILAHKRMLEMEDEAEERKLDHEHRMAELDQAIAAKEEQVQASEDYLDQALFLLGEDVYAQRINDAQLAPFYPRLDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D734</accession>
    <name>Q1D734_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553375.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3342"/>
    <dbReference type="EnsemblBacteria" id="ABF92320">
        <property type="protein sequence ID" value="ABF92320"/>
        <property type="gene ID" value="MXAN_3342"/>
    </dbReference>
    <dbReference type="GeneID" id="41360693"/>
    <dbReference type="KEGG" id="mxa:MXAN_3342"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188332_0_0_7"/>
    <dbReference type="OMA" id="YCGSCAP"/>
    <dbReference type="OrthoDB" id="1284496at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="23848" checksum="0512204EA2A7FD28" modified="2006-07-11" version="1">MSACPFCQNSMQLTPSSELPLETCGACGAVWFEGEALTKVMGGSVSDALLRRAKNRPGCCKGCQGELQFVPECTHCGTRAPTCPRCGRAPLPVVEVFGVTMEVCSGCAGVALDEGELQQLQDAVETYRDEPLDARATVRLEGPPCCTACRRKLRLEHGFVAEERLYCGSCAPSGATPYRETFSSHDIPMFVPTRRGGQTFNLAGYASEGLMWLLHRMLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A7</accession>
    <name>Q1D7A7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thiamine-phosphate pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553312.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3267"/>
    <dbReference type="EnsemblBacteria" id="ABF89773">
        <property type="protein sequence ID" value="ABF89773"/>
        <property type="gene ID" value="MXAN_3267"/>
    </dbReference>
    <dbReference type="GeneID" id="41360619"/>
    <dbReference type="KEGG" id="mxa:MXAN_3267"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_4_7"/>
    <dbReference type="OMA" id="EVDFIHI"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="22146" checksum="2B9F58341D88A6D9" modified="2006-07-11" version="1">MVPSTVPRLVVITDWRLPSERLRWALTRALDAGPEVAVQHRHPEATGRRFLDEARELAALCHPRGNPLFINGRVDVALLVGAHIHLPAHGPSPMDVRPHLPAGRWISAAVHDVAEAHAARGANLALVSPVFAPGSKPGDTRPPLGPEGFSALAAALPCPALALGGITPARAMTLPDAAGFAVISSVLEADDPTAAARSLLAARAGRAMLRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7M4</accession>
    <name>Q1D7M4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553196.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89865">
        <property type="protein sequence ID" value="ABF89865"/>
        <property type="gene ID" value="MXAN_3146"/>
    </dbReference>
    <dbReference type="GeneID" id="41360505"/>
    <dbReference type="KEGG" id="mxa:MXAN_3146"/>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228823_0_0_7"/>
    <dbReference type="OMA" id="FGGNFWA"/>
    <dbReference type="OrthoDB" id="1401707at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188294" evidence="1">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="229" mass="25103" checksum="901459A6C8D55DD7" modified="2006-07-11" version="1">MPMQTLSRPTARTLVLLSFLVSWPAFAEVEEARDPGFPRWLAISARGGYLMPGGRMDGAAEPLYLYEIYKGLFAAIVEPTIRIASRVEVGPWAQFSHAQMRIRCSAERTCKGSNLRFGLQGNYHWNPSGPIDLWSGVALGYDTSSVSVPAAEVTYSGPDVTLQAGFDRNFGGNFWAGLFVVGTGGQYDKLDVRLLNGSGSETLRERAFHLWIGFGFRVRVAAPHPAVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7T0</accession>
    <name>Q1D7T0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3090"/>
    <dbReference type="EnsemblBacteria" id="ABF88692">
        <property type="protein sequence ID" value="ABF88692"/>
        <property type="gene ID" value="MXAN_3090"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3090"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756892_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="148" mass="16555" checksum="236A565C835E44A6" modified="2006-07-11" version="1">MISSRETMETFMVSEPSTLKLVQPQKELERRGIPVLTSGYVRTLDVADGQLLGEVGFRIKSRRRLPPGSRRQEMAPTLFATLECAVRDDQAAHRVFRFLAELGFRPDGLHLERYLPGVADRYLLMLGVQRLRPVVANGEGGSSPMASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D826</accession>
    <name>Q1D826_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553044.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2988"/>
    <dbReference type="EnsemblBacteria" id="ABF88392">
        <property type="protein sequence ID" value="ABF88392"/>
        <property type="gene ID" value="MXAN_2988"/>
    </dbReference>
    <dbReference type="GeneID" id="41360350"/>
    <dbReference type="KEGG" id="mxa:MXAN_2988"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534025_0_0_7"/>
    <dbReference type="OMA" id="HHHRSFQ"/>
    <dbReference type="OrthoDB" id="338446at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="142"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="369"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="52964" checksum="1B00B65925B8B849" modified="2006-07-11" version="1">MPRPDGPSKHVLLKERFQITRPLEEMELRLVRASLANAALVDLREEAILRTVLSLARLYKVRHGERDVGVGALLTPFREEVERRLGPVLQAPFPPTRDRLMPHVKDLRQHAAKARDMVAQRLRGRVPPEALDREIRHKELVLVTGGGGGTAYVYLGVMSLLGEYGLEPRLLAGTSMGAILAIMRSRLTRFDATDMINIVRGLSFRKLFRFISTESRYGLPAALRLFLRAGLGRFFSAGPENSGMRLKDLPVPTLIAVGGIRRGMLPRPLEYYERLLGTSPLGLLNPVGVARRIQAAMGAMAELFTRPEITARLYLGADDTTGDFDALDAAGFSSALPGVIHYDVLREDPGMHTLVEGLMGQHGVARLIDGGLVDNLPAKAAWKAVARGRIGTRNAFILALDGFAPKLTTPFWLPLQRLAAMTVAPNLPYTHHVKRFPRTLSPLDVVPSVELASKALQFGRTALAEDLPFLRRMLAPLPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D1</accession>
    <name>Q1D8D1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, iron-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2881"/>
    <dbReference type="EnsemblBacteria" id="ABF87647">
        <property type="protein sequence ID" value="ABF87647"/>
        <property type="gene ID" value="MXAN_2881"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2881"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_7"/>
    <dbReference type="OMA" id="PRVWAFN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="392" mass="40039" checksum="6501294A011026A7" modified="2006-07-11" version="1">MTDVSASSSFEFATATRVVFGPGRLAEAPEIIRGLGGSRVLLVTGANPSRARPLHDALERLGLGVTVFSVDGEPTVERAREGTARVAEAGCDVVVALGGGSALDAGKAIAALAANGGDPLDYLEVIGRGQPLTRPSLPFMAIPTTAGTGSEVTRNAVLGSKDAKAKASLRSPHMLPRVALVDPDLLTGAPAAVLASSGMDALSQLIEPYLSARANPLTDALAREGLRRSARSLRRAVLDGPDAPAREDLALASLFGGLCLANAGLGAVHGFAAPLGGMFDAPHGAVCAALLPAVLDVNLRALRARAPTHPSLPRVQELAALLTGRVDARAEDAVTWVDELRAALGVPGLGRYGLTEAQVPALVAKAKEASSMKANPLVLTDAELAEIASRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I2</accession>
    <name>Q1D8I2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2830"/>
    <dbReference type="EnsemblBacteria" id="ABF91783">
        <property type="protein sequence ID" value="ABF91783"/>
        <property type="gene ID" value="MXAN_2830"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2830"/>
    <dbReference type="HOGENOM" id="CLU_2650674_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="76" mass="9054" checksum="B623F6BF7543168C" modified="2006-07-11" version="1">MSKQVEKQEWVRVAEAFEASGQTQKEFSAQRGVRLSTLQSWVYRRDASVAARQHRCACYRWRWLACRGRARCCSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q9</accession>
    <name>Q1D8Q9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552814.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2747"/>
    <dbReference type="EnsemblBacteria" id="ABF88331">
        <property type="protein sequence ID" value="ABF88331"/>
        <property type="gene ID" value="MXAN_2747"/>
    </dbReference>
    <dbReference type="GeneID" id="41360124"/>
    <dbReference type="KEGG" id="mxa:MXAN_2747"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_0_7"/>
    <dbReference type="OMA" id="CEMLGEF"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="535" mass="58408" checksum="A37BA669B86BC130" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8U7</accession>
    <name>Q1D8U7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002634858.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2709"/>
    <dbReference type="EnsemblBacteria" id="ABF87697">
        <property type="protein sequence ID" value="ABF87697"/>
        <property type="gene ID" value="MXAN_2709"/>
    </dbReference>
    <dbReference type="GeneID" id="41360087"/>
    <dbReference type="KEGG" id="mxa:MXAN_2709"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_5_7"/>
    <dbReference type="OMA" id="VARVMFN"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="12879" checksum="BD493E6AF22A7A56" modified="2006-07-11" version="1">MSDLGKRIGQRIRELRTQRPERWTQEELAERAQISVSFLSMIERGERVPHVETLAALANALGVSLGELFTGTEQTLAQTEDLLRPLSDFARARGLTARDVDRLLGVARVMFSGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8X7</accession>
    <name>Q1D8X7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily subfamily IB hydrolase, TIGR01490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2679"/>
    <dbReference type="EnsemblBacteria" id="ABF92316">
        <property type="protein sequence ID" value="ABF92316"/>
        <property type="gene ID" value="MXAN_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2679"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052657_1_1_7"/>
    <dbReference type="OMA" id="DHDQMER"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="27979" checksum="EA360D26FBF4EF01" modified="2006-07-11" version="1">MCGGVRSVLRHPSGGIRGPGVAVAFFDLDKTLIAANSGSLWIRRELELGHISRFQALRASLWIARYHLGFVSMQDAVARAIAQLAGTPARPLQERTAVFYEEQVRPLYRPGAWAVLDAHRRAGERLVLLTSSTGYLSELVARELGLDAVLCNRFEVDGAGLHTGRALGTICFGEGKRVCAEAYVREAGVALSACAFYTDSYSDLSVMEVVGRPVAVHPDHRLRRHARKRGWPVVDWGVPPGGDVPAVPPAPPVVPSTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D909</accession>
    <name>Q1D909_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mreC</name>
        <name evidence="6" type="ORF">MXAN_2645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552715.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2645"/>
    <dbReference type="EnsemblBacteria" id="ABF87437">
        <property type="protein sequence ID" value="ABF87437"/>
        <property type="gene ID" value="MXAN_2645"/>
    </dbReference>
    <dbReference type="GeneID" id="41360021"/>
    <dbReference type="KEGG" id="mxa:MXAN_2645"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_0_7"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="30379" checksum="AE88657C6BB9080F" modified="2006-07-11" version="1">MWSLLKRYYRPLIVGFLLLSPLVAFLLGGRKGREPNFVDRAIIAVASPVQQGLTSVIEGGVAGVQNYLDLRGVRQENDALRLENLQLRAAVQSLGESRMENERLRKLLNYAEAEPGPEIPARVVGVNPVAKLLSVRISSGEQQGVFRGMSVVTPDGIVGQVIRATGGYADVALVTDPQSRVAVRVQRSRARGTAAGTGGGPLKLENMLRTEDVEDGDLIITAGTDGIYPPGVVVGRVTNLEKKEHGMFQGADIVPAVDTSKLEEVLVVGSPYSAMAPGSAAEGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D955</accession>
    <name>Q1D955_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552669.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2599"/>
    <dbReference type="EnsemblBacteria" id="ABF89785">
        <property type="protein sequence ID" value="ABF89785"/>
        <property type="gene ID" value="MXAN_2599"/>
    </dbReference>
    <dbReference type="GeneID" id="41359976"/>
    <dbReference type="KEGG" id="mxa:MXAN_2599"/>
    <dbReference type="eggNOG" id="ENOG5030IEA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039479_0_0_7"/>
    <dbReference type="OMA" id="YYLNTRY"/>
    <dbReference type="OrthoDB" id="454823at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="550" mass="60844" checksum="DB40BE8C04B94CEB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D974</accession>
    <name>Q1D974_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552650.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2580"/>
    <dbReference type="EnsemblBacteria" id="ABF90415">
        <property type="protein sequence ID" value="ABF90415"/>
        <property type="gene ID" value="MXAN_2580"/>
    </dbReference>
    <dbReference type="GeneID" id="41359958"/>
    <dbReference type="KEGG" id="mxa:MXAN_2580"/>
    <dbReference type="HOGENOM" id="CLU_1068863_0_0_7"/>
    <dbReference type="OMA" id="YEEYSWQ"/>
    <dbReference type="OrthoDB" id="1226174at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188276" evidence="2">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="28538" checksum="ABFD0F3ED9D0EB67" modified="2006-07-11" version="1">MRRSWVAVFAAGWLVACGGNSLPAGDSQDPTPGGGLPGEPVQPGGPDDQGNGEEPTGSQSLWPLTAGSTWTYDIQDPVEGNFQKQVTVVGPGEVPDQPGINAVQVHSRQDRVRNGTLYEEYSWQVELTNGLVVRLREDDYRNGQQVRSTTWSPATVKSVASVPDALPWTYKSDVLEHITLGDGSKDQKDPTYIWKVLESGVTVTTRAGTFTNAVKIQRDKVNNNGEVKPDKTRFYWLVPGIGKVREEGERTEDLAAYDIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D990</accession>
    <name>Q1D990_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">MPT synthase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Molybdenum cofactor biosynthesis protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Molybdopterin-converting factor large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Molybdopterin-converting factor subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moaDE</name>
        <name evidence="11" type="ORF">MXAN_2564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12160"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552634.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2564"/>
    <dbReference type="EnsemblBacteria" id="ABF86667">
        <property type="protein sequence ID" value="ABF86667"/>
        <property type="gene ID" value="MXAN_2564"/>
    </dbReference>
    <dbReference type="GeneID" id="41359942"/>
    <dbReference type="KEGG" id="mxa:MXAN_2564"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069141_1_0_7"/>
    <dbReference type="OMA" id="SEWKGHQ"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24616" checksum="9CCA85A8CE77B52A" modified="2006-07-11" version="1">MADARNVRITVLYFAAARERTGQVREALDLPEGSHVRDVLRLLSAKYAALAPLLPHLRVAVDQEFVGPDAPVRDGAEMALIPPVAGGAPGKFLVVDRPLRLEEVVEAVRGESYGGLVTFSGSVRNQTKGRRVLRLEYEAYAPMAEKKLAEIGAEAAERFPGVRVSIIHRVGTLVPGELAVVIAAASPHRKEAFGGCEYAIERLKQDVPIWKKEFFEDGEVWVGLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9R9</accession>
    <name>Q1D9R9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552459.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2384"/>
    <dbReference type="EnsemblBacteria" id="ABF87003">
        <property type="protein sequence ID" value="ABF87003"/>
        <property type="gene ID" value="MXAN_2384"/>
    </dbReference>
    <dbReference type="GeneID" id="41359769"/>
    <dbReference type="KEGG" id="mxa:MXAN_2384"/>
    <dbReference type="HOGENOM" id="CLU_1618031_0_0_7"/>
    <dbReference type="OMA" id="WVRPETC"/>
    <dbReference type="OrthoDB" id="1677805at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="18220" checksum="A0ECB09BA3840121" modified="2006-07-11" version="1">MDSVTTPNTSPSVPTDWVRPETCVALDAFFQGFGFESAEDLAVLAAWALEGVTASNVKPQAAVALARARMETWLTRVLDMDVVGEGRLLTRGRAAFVLSDGARFGASVLTRDAVPRELYRALRAAVPVPTPAQVATQMPEQQLVLWPLGERLRRWLRAGQPDMSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK8</accession>
    <name>Q1DAK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552170.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2085"/>
    <dbReference type="EnsemblBacteria" id="ABF88711">
        <property type="protein sequence ID" value="ABF88711"/>
        <property type="gene ID" value="MXAN_2085"/>
    </dbReference>
    <dbReference type="GeneID" id="41359493"/>
    <dbReference type="KEGG" id="mxa:MXAN_2085"/>
    <dbReference type="HOGENOM" id="CLU_2368053_0_0_7"/>
    <dbReference type="OrthoDB" id="1798980at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="95" mass="10407" checksum="16AAE02F5704E39D" modified="2006-07-11" version="1">MSVNALKFIVWTCCAVGLGVFLASGKVDGRTPLNHMERAWSRSVSPSTVDRLKDGLEDAYEDAKDAVAGNKDSSPRERISAEDREAVNRIIAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT3</accession>
    <name>Q1DAT3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="7">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="7">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552095.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2005"/>
    <dbReference type="EnsemblBacteria" id="ABF89353">
        <property type="protein sequence ID" value="ABF89353"/>
        <property type="gene ID" value="MXAN_2005"/>
    </dbReference>
    <dbReference type="GeneID" id="41359415"/>
    <dbReference type="KEGG" id="mxa:MXAN_2005"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_3_7"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="20702" checksum="8B89EA937C936384" modified="2006-07-11" version="1">MTVKPRLLFATTNQGKLRELRGLVGDAVEVVSLADLPPVPEPVEDGATFEENAVMKARAYADATGLLTLADDSGLCVDALGGRPGVQSARYAPGDDRARYEKLLTELTGVPDAQRTASFRCALALVGPGGGEAKVEVGQCNGRIGHAPKGSHGFGYDPVFILPGGDRALAELTPEEKSAISHRGKAFQKMKPHLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY2</accession>
    <name>Q1DAY2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552046.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1953"/>
    <dbReference type="EnsemblBacteria" id="ABF90368">
        <property type="protein sequence ID" value="ABF90368"/>
        <property type="gene ID" value="MXAN_1953"/>
    </dbReference>
    <dbReference type="GeneID" id="41359366"/>
    <dbReference type="KEGG" id="mxa:MXAN_1953"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_16_0_7"/>
    <dbReference type="OMA" id="QISIAVM"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="16917" checksum="5B1EB9DC2C3075AA" modified="2006-07-11" version="1">MDAAVLKKVALFEGLTQGQLAKVAQIGHSRTYPAGAFLFREGETGQEMFVIAEGKVRISKSVPGIGEEALAILEPGQYFGEMAVIEDSPRSADAIAHVSCSVWVIERSRLDQLMFTDKDLAYVLLWTFVRTLSERLRETNEKIKGFFALSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC15</accession>
    <name>Q1DC15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551667.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1556"/>
    <dbReference type="EnsemblBacteria" id="ABF87881">
        <property type="protein sequence ID" value="ABF87881"/>
        <property type="gene ID" value="MXAN_1556"/>
    </dbReference>
    <dbReference type="GeneID" id="41359001"/>
    <dbReference type="KEGG" id="mxa:MXAN_1556"/>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_5_7"/>
    <dbReference type="OMA" id="RTVAAWY"/>
    <dbReference type="OrthoDB" id="1781735at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="25061" checksum="904B78AAB2C477D3" modified="2006-07-11" version="1">MPRPPPDVIRYPSYYTPSVRRALSRADPTLGALMKSVGPFRLQVRPLHSPFGALAESIVYQQLHGKAAATIFGRVCERVGSGRKFTPEALLAVPDTSLREAGLSANKLAALQDLARKTLDGTVPPLAKVRRMDDAELIEHFTQVRGIGQWTVEMLLMFQLERPDVLPVDDYGVRKGFMKAYGLTEMPKPKALLAYGERWRPWRSVASWYMWRSAELPDAPTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC71</accession>
    <name>Q1DC71_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551611.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1500"/>
    <dbReference type="EnsemblBacteria" id="ABF87761">
        <property type="protein sequence ID" value="ABF87761"/>
        <property type="gene ID" value="MXAN_1500"/>
    </dbReference>
    <dbReference type="GeneID" id="41358946"/>
    <dbReference type="KEGG" id="mxa:MXAN_1500"/>
    <dbReference type="eggNOG" id="ENOG5031DE8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2554722_0_0_7"/>
    <dbReference type="OMA" id="LRPKVPF"/>
    <dbReference type="OrthoDB" id="1906776at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="11316" checksum="0F31FDE421419E6E" modified="2006-07-11" version="1">MSPTGRTLALRRAREEAHTTMATLNITYDGMSADVPVELDGPVPDTDIRRIATELVRSGGVPGLHLSQLRDDAFAHFVVDRFRGARGEERIYLRPKVPFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCP7</accession>
    <name>Q1DCP7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemin ABC transporter, periplasmic hemin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551436.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1319"/>
    <dbReference type="EnsemblBacteria" id="ABF90147">
        <property type="protein sequence ID" value="ABF90147"/>
        <property type="gene ID" value="MXAN_1319"/>
    </dbReference>
    <dbReference type="GeneID" id="41358765"/>
    <dbReference type="KEGG" id="mxa:MXAN_1319"/>
    <dbReference type="eggNOG" id="COG4558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_6_0_7"/>
    <dbReference type="OMA" id="PNVGYMR"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188399" evidence="1">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="30818" checksum="2F818CC81ECADC2A" modified="2006-07-11" version="1">MSRAFGLSWVFMAVASLAHAAAPAPAKPPAAAAAKAPVNAAKLVTVGPAITETVFALGAGGQVVGVDDTSLALEVARKSPKVGYQRALSSEAIVALGTSQLLASEEAGPPGVLEQLKTVGVDVVVLPNKHTVEATRERIRTLAQRLGKAEQGEALVKQLDSDLRKAQERTAARKDAKPPRVLALYARGANVLMVAGAGTAAGELVTLSGGVNAIAGYAGHKPLTAEAVVEAAPDFILMPASSLEPVGGEEGLSRTPGLSQVRGWRLITVDDVHFMGLGPHLGKAVSRLQDGYTSPARGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCQ6</accession>
    <name>Q1DCQ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551427.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1310"/>
    <dbReference type="EnsemblBacteria" id="ABF87978">
        <property type="protein sequence ID" value="ABF87978"/>
        <property type="gene ID" value="MXAN_1310"/>
    </dbReference>
    <dbReference type="GeneID" id="41358757"/>
    <dbReference type="KEGG" id="mxa:MXAN_1310"/>
    <dbReference type="HOGENOM" id="CLU_1110493_0_0_7"/>
    <dbReference type="OMA" id="HAWRSGV"/>
    <dbReference type="OrthoDB" id="1630116at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188385" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="29051" checksum="2323E1D936A6BB35" modified="2006-07-11" version="1">MRWSSALLLPLCLATTACGTSAKHQALLERRDAIRLADVEREEGARERYRSNSGFQDTRWGMTKDEAMTALPFHARVINAWGDVHVADVVAGRRADAYYVFAQGQLAEVTLHFHAPGAVRDNFNAVAELLTMKYGKPATREDSARDAEGRLALAQMANNLSEASANYHAWRSGVQPSGPAVDNFGRQMEANARTDAALAVHEYLLRSTWTETETELRLTGSQEPGARSLTLTYTSQRLKPYLSKELAVRDQQRKAEQSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCU4</accession>
    <name>Q1DCU4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551389.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1272"/>
    <dbReference type="EnsemblBacteria" id="ABF89930">
        <property type="protein sequence ID" value="ABF89930"/>
        <property type="gene ID" value="MXAN_1272"/>
    </dbReference>
    <dbReference type="GeneID" id="41358718"/>
    <dbReference type="KEGG" id="mxa:MXAN_1272"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052611_1_0_7"/>
    <dbReference type="OMA" id="GNHDVFT"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="31632" checksum="F39AA5C2D71CF792" modified="2006-07-11" version="1">MAEIPSMRIAHCSDVHITEDYFALPLHRLGWRRWMALAELTVGGRARRYARAPQALAAIARDAQAAQVDHFILSGDLTAYALDAEFSGARQSLGALAEDPRRCTVIPGNHDVFTPGSHRTGRFAKYFGHLLESDLPEYRREGAFPFVRLLGTEAAVVGLLSARVPRTPGLSYGVIGEAQLGGLAALLKDARLEGRAILVVVHHAPLNPHGRPDRWHHGLRDADALLKLLPGPRYAVLHGHIHRRYHHPATADRPHVFGAGSSTESGHEGYWLIDVADGQVSGGQQQTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW9</accession>
    <name>Q1DCW9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator SasR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sasR</name>
        <name evidence="9" type="ORF">MXAN_1245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1245"/>
    <dbReference type="EnsemblBacteria" id="ABF89094">
        <property type="protein sequence ID" value="ABF89094"/>
        <property type="gene ID" value="MXAN_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1245"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="YYRLHIV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="155"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="477" mass="52292" checksum="2C2AF909C7E74CB1" modified="2006-07-11" version="1">MQGESTQAMARILVIDDHDTLREGMAVTLTRAGHTVSAVRSGQDGLAAYRKAPFDLVVTDLKMDGMDGIEVTKSLKALDAGAVVMVVTAFGTIETAVQAMQQGAYDFITKPFPPEVLRAKVDKGLELASTRKQVERLTARTAAHDTDAALTHGSLVGDSEPMQRLVSQVLKVAQSDATVLVRGESGTGKELVARMLHQRSPRRDGPFIVVHCAALAETLLESELFGHERGAFTGAVKRKLGRFELADGGTLFLDEIGEIPASVQTKLLRVLQEKEIQRVGGEDTFKVDVRVVSATHRDLQAEVKAGRFREDLYYRLHIVPVVLPPLRERPEDISLLARHFVAKHAMRVNRRVMGLDDSALRALARHAWPGNVRELENVIEQALVFAEGEQLTDLDLPSHLTASGTPRVEAGLPVLQGDRPLPDILEDLERQLIARAYEKASGVKTETARLLGIKTSALYYKLEKYGFLPKGTPPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD18</accession>
    <name>Q1DD18_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1196"/>
    <dbReference type="EnsemblBacteria" id="ABF88189">
        <property type="protein sequence ID" value="ABF88189"/>
        <property type="gene ID" value="MXAN_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1196"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304207_0_0_7"/>
    <dbReference type="OMA" id="CMSSIAF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="22653" checksum="E2732962244E09F3" modified="2006-07-11" version="1">MPRTYTAQAGDCVSSISHAHNLSPQRVWEAPENESLRRERTSPHVLKPGDTVTLPDKEIRQVPCATGRTHTFRLKGIPERFRLRLHEDGAPRTKVPYRLVIGDVTHEGETNEQGLIECGIPPGAREATLEVGGEEYTLSLGTLQPVSTEEGLRARLVNLGFLADEASEEDALSEAVARFQAEYGLMPNGTVDERTRHKLREAHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD53</accession>
    <name>Q1DD53_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparaginase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DD53"/>
    <dbReference type="STRING" id="246197.MXAN_1160"/>
    <dbReference type="EnsemblBacteria" id="ABF91922">
        <property type="protein sequence ID" value="ABF91922"/>
        <property type="gene ID" value="MXAN_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1160"/>
    <dbReference type="eggNOG" id="COG1446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_7"/>
    <dbReference type="OMA" id="YSRMRWK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="238"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="36601" checksum="317C1B87A86C3E38" modified="2006-07-11" version="1">MGCATQTGAARTDSEQPTSRDAPAPKPKWGLVIHGGAGVISRENLSPEREEEVRAALTQSLQAGHAVLASGGSALDAVSAAVRILEDSPYFNAGKGAVFTHDGVNELDAAIMDGTTRKAGAVAGLRHVKNPISLARLVMEQSPHVMMVGEGAEAFAKSQGVELVDPKYFYTEDRWQGLQRALEKERSQPQPSSALPAGYDPVSGDHKFGTVGAVALDQTGALAAATSTGGMTNKRYGRVGDSPIIGAGTYADARCAVSATGHGEFFIRYTVARDICARVEYQNVPLPEAADVVINDVLVKVGGEGGVIAMDREGNVAMPFNSAGMYRGYVGEDGKPVVAIFRDAAEAAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDC0</accession>
    <name>Q1DDC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1093"/>
    <dbReference type="EnsemblBacteria" id="ABF92344">
        <property type="protein sequence ID" value="ABF92344"/>
        <property type="gene ID" value="MXAN_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1093"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092045_0_0_7"/>
    <dbReference type="OMA" id="ICKVSQQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="77"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="22365" checksum="B52BAA8A653E1187" modified="2006-07-11" version="1">MQQEGSTAMTDQLYTTHDISRLLQVDPSTVSKWIDRGILMAFRTPGGHRRVRSADLRTFLITHQMPVPEELGSGTVRLLAVDDERPVLDAIKRAFKPFAAQVELQTTTSGVEALLLVSEQKPHGMIIDLNMPDIDGLEVCRRIRARKQMEGVRLITMTSAHTPEVVEQSKQAGALACMAKPLDVQQVLELFRVPLALSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH5</accession>
    <name>Q1DDH5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551158.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1037"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88774">
        <property type="protein sequence ID" value="ABF88774"/>
        <property type="gene ID" value="MXAN_1037"/>
    </dbReference>
    <dbReference type="GeneID" id="41358491"/>
    <dbReference type="KEGG" id="mxa:MXAN_1037"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_0_7"/>
    <dbReference type="OMA" id="DDLWFPW"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="34399" checksum="3EC261D6BCAE8DB9" modified="2006-07-11" version="1">MPFFSVIIPTYNRARLLEAALASVFAQEERDFEVLVVDDGSTDDTLETLARYGEQVRVLSQRNAGPGAARNLGIQEARGTYVAFLDSDDVWFPWTLATYRRVLEAEGTSLVLGTAALFSRAETLATVSREPLQVLRFADYLASAEDRTPRTACVLAVRTEALRRVGGFTPLRISGEDYDLLYRLGTDPGFAWVRAPVVVGYRQHVGSTSTSLESGYRGTRYLLEQERLGRYPGGTARRRERLEMLLYSLRHVTHWLLSQRRVDLALDLYRRGLPLHLAVPRWRYMLGFPPWALATTVRQRVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE28</accession>
    <name>Q1DE28_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550955.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0833"/>
    <dbReference type="EnsemblBacteria" id="ABF91677">
        <property type="protein sequence ID" value="ABF91677"/>
        <property type="gene ID" value="MXAN_0833"/>
    </dbReference>
    <dbReference type="GeneID" id="41358296"/>
    <dbReference type="KEGG" id="mxa:MXAN_0833"/>
    <dbReference type="HOGENOM" id="CLU_138492_0_0_7"/>
    <dbReference type="OMA" id="LECKARV"/>
    <dbReference type="OrthoDB" id="1933413at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="17900" checksum="3CB1135222669A3E" modified="2006-07-11" version="1">MCHGLAGFWDFVPTRHIPYASSPSPGSPAGLPPGEGWNMNSASVNESPTDRRRFPRLEAPLYARPARLRRVDKQQVLDASLGGIRIYSDEQYTQDSELELDLFLRDGTSLECKARVAWMRKLPKDAVARFEVGLAFTDVPPLAMDKLKSVLVVDDEGGPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA3</accession>
    <name>Q1DEA3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transgly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550880.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0754"/>
    <dbReference type="EnsemblBacteria" id="ABF89837">
        <property type="protein sequence ID" value="ABF89837"/>
        <property type="gene ID" value="MXAN_0754"/>
    </dbReference>
    <dbReference type="GeneID" id="41358224"/>
    <dbReference type="KEGG" id="mxa:MXAN_0754"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128117_0_0_7"/>
    <dbReference type="OMA" id="YFQTPRE"/>
    <dbReference type="OrthoDB" id="1099011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transgly" evidence="1">
        <location>
            <begin position="146"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28942" checksum="43A3B627B13B83F0" modified="2006-07-11" version="1">MKSLLWTILFMLGLAGVVIPLTYLYTASKLPPLESEFDVEKQLKHSIEGERMSLRAGQSQRNPRPITFVRPDFSKLPKDLVALYIRHLECPRYFQTPREDGPAWAWRLFLGATVGTSPPGDGACERVLAMRIAAALGIEGTRERSVAAHRIHTFMQKDQLIAYDLSIIYFERGIVGVEDAALALFGRELSELKLEELAELQLALPPYSDYYGIKICKNPTVLRQDRNRLLEDLAAWRLVSEDRARNAMAQPLACAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE2</accession>
    <name>Q1DEE2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, CheR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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            <end position="278"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="278" mass="31327" checksum="DF78950A7746FFDE" modified="2006-07-11" version="1">MTGPGARGAELEALEVDLLLEGVARQWGFDLRSRSRPQLLRRLRHHLREERLDSFSALQARVLHDAEALDALLRTLSCTPPALFAEAAFFRDFRTRVVPVLRTWPSVRVWHAGCGTGEDTYALAILLHEEGLWGKCRLYASDASEGLLADARTGVLPLPTQEDAQRYLEAGGKGALSDYYTRDGNWALLQPRLRDGIFFTQHNLATDGSFNEFHVIVCRDTLLTFNRALHDHIHGRLFESLARFGFLCLGRKESLARTPHAGAYEMLDDCGRIFRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DET5</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="306"/>
            <end position="420"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="680" mass="68932" checksum="4D1A26FDD5C83322" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF22</accession>
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        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF86880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="246197.MXAN_0481"/>
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    </dbReference>
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    <dbReference type="OMA" id="QARGNRW"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188473" evidence="3">
        <location>
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            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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        </location>
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            <end position="576"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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            <begin position="741"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="775" mass="83020" checksum="9F69F90AE74FF04F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF94</accession>
    <name>Q1DF94_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_0408</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF91075">
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        <property type="gene ID" value="MXAN_0408"/>
    </dbReference>
    <dbReference type="GeneID" id="41357902"/>
    <dbReference type="KEGG" id="mxa:MXAN_0408"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_8_0_7"/>
    <dbReference type="OMA" id="VIAHFDW"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="28601" checksum="E4DE23D9E1181701" modified="2006-07-11" version="1">MCPRGEEPVMQVDFGRTSSDYVRHRAGFPEAFFERLDREGLLRSGLRAVDLGTGTGTVARGLAQRGAVVTGLDVSADMLDAARGLASGMGLGIDFRQAPAENTGLPSQAFELVVAGQCWHWFDRPAAAREAARLLVPGGRLVIAHFDWLPLPGNVVEATERLIERFNPGAPAPFVSLSQSSGVYPPWFRDAAEAGFTQLTSFSFDVSVSYSPRAWRGRIRASAKVGASMPASAVSGFDAALADLLAGSFPADSLDIPHRVFALLATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC1</accession>
    <name>Q1DFC1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">MXAN_0378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550516.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0378"/>
    <dbReference type="EnsemblBacteria" id="ABF88562">
        <property type="protein sequence ID" value="ABF88562"/>
        <property type="gene ID" value="MXAN_0378"/>
    </dbReference>
    <dbReference type="GeneID" id="41357876"/>
    <dbReference type="KEGG" id="mxa:MXAN_0378"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_7"/>
    <dbReference type="OMA" id="TMTVAVR"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="441" mass="48423" checksum="C0E74C1549855B92" modified="2006-07-11" version="1">MMESPQSAALSMEELHEAWPVLSVDERLEGFRLLPASVADDFFLALSAREQAELILHLQPAERRTWVRLLPPDDLADLVQAVEPEQAESILSQLDDASRREVNVLLAYAEDDAGGLMNPRFARVRPDMSIDEAISYLRKQARERVETVYYAYVLDAEQHLLGVLSLRQLFQTASDKRVADVMQRDVITVSEDTDQEAVSRLFTEHGFMALPVLDVQQRMKGIVTVDDIVDVVQEEATEDIQKAGGMEALEAPYFETGFFGMLKKRIGWLLVLFLGQMLTATAMSSFEDEIATAVVLSLFVPLIISSGGNSGSQASTLIIRSLALGEMRLRDWWRVARRELLSGLVLGVVLGVVGLARILIWNSISGVYGEHALVLGITVALSVLGVVTFGTLAGSMLPLVLRKFGFDPASASAPFVATLVDVSGVLIYFTVASLLLRGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL8</accession>
    <name>Q1DFL8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550419.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0274"/>
    <dbReference type="TCDB" id="1.A.30.2.3">
        <property type="family name" value="the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87962">
        <property type="protein sequence ID" value="ABF87962"/>
        <property type="gene ID" value="MXAN_0274"/>
    </dbReference>
    <dbReference type="GeneID" id="41357774"/>
    <dbReference type="KEGG" id="mxa:MXAN_0274"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_7"/>
    <dbReference type="OMA" id="KEQTNTM"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14835" checksum="D5B646CCA1BAA9E2" modified="2006-07-11" version="1">MSTPRRSLTPEMNVTPLVDVVLVLLIIFMVVTPQIESGAAVELPTATNPDKENKELTPTTVSLSATGAFFLDRKELKRDALMAELKAVRAKDPDSPVVLKADRGVRYSEVRGLFKAMQELGFPGINLQVVDKQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR4</accession>
    <name>Q1DFR4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_0227</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0227"/>
    <dbReference type="EnsemblBacteria" id="ABF88952">
        <property type="protein sequence ID" value="ABF88952"/>
        <property type="gene ID" value="MXAN_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0227"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
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    </dbReference>
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        <property type="entry name" value="sCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
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    </dbReference>
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    <keyword evidence="7" id="KW-0807">Transducer</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="279"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF88952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="553" mass="58974" checksum="76774730B63784F8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFW7</accession>
    <name>Q1DFW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_0173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0173"/>
    <dbReference type="EnsemblBacteria" id="ABF91938">
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        <property type="gene ID" value="MXAN_0173"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_0173"/>
    <dbReference type="HOGENOM" id="CLU_137338_0_0_7"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="18089" checksum="6A90B91A65EE7ECA" modified="2006-07-11" version="1">MRELTQWPPGLLAVASHPLHSVLALLPGLGWNRGRMRLMGMMAGGPPPEDDEEENVFSRARGPSPAEKRTRKAVLVGLVLLLLGGVWLYLQGGENRALNALSPAQRASLFQETRDSFHEMCMGDAGTSRFPKRCAQMADFLTRFTECDATCQQEIAPALQRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG42</accession>
    <name>Q1DG42_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF91082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF91082">
        <property type="protein sequence ID" value="ABF91082"/>
        <property type="gene ID" value="MXAN_0098"/>
    </dbReference>
    <dbReference type="GeneID" id="41357605"/>
    <dbReference type="KEGG" id="mxa:MXAN_0098"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021082_2_0_7"/>
    <dbReference type="OMA" id="FQRPLRW"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="557" mass="62739" checksum="57FAE798C3C445A4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA5</accession>
    <name>Q1DGA5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, substrate-binding protein, aliphatic sulfonates family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550184.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0035"/>
    <dbReference type="EnsemblBacteria" id="ABF88636">
        <property type="protein sequence ID" value="ABF88636"/>
        <property type="gene ID" value="MXAN_0035"/>
    </dbReference>
    <dbReference type="GeneID" id="41357544"/>
    <dbReference type="KEGG" id="mxa:MXAN_0035"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_7"/>
    <dbReference type="OMA" id="GPAINTF"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="35514" checksum="7A1A94795EB11E9B" modified="2006-07-11" version="1">MRVFHSLLPVVVAGLAVLGAGCKRESAARGPDAPLRLGFFPNITHAQALVGNAEGTFASQPGVGRLEVMQFNAGPAAMEALVAGSLDVSYVGSGPAINTFLKAGRELRVIAGAVNNGAVLVVRTVKTPAELKGKKLASPQLGNTQDIALRYWLKQQGLTTHLDGTGDVQIFPLSNPDILGQFLRGGIEGAWVPEPWGARLVAEGKGRILVNEKDLWPGGRFPTTVLVTTRQVLETQRPRVVALLRAHVRLTERWQEDPAGFTTAANVAFGRLTSKPLPAGILQQAFSRLEPSLDPVPQALATAAEHAKTLGFITDANIDGLVDLSLLDEAQAGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ0</accession>
    <name>Q1CVJ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91734">
        <property type="protein sequence ID" value="ABF91734"/>
        <property type="gene ID" value="MXAN_7479"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7479"/>
    <dbReference type="HOGENOM" id="CLU_3382853_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="33" mass="3854" checksum="785D3B96793B5C4F" modified="2006-07-11" version="1">MSQRGLRSSTIQCLLHVERLMRFVMHGGPRWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV1</accession>
    <name>Q1CVV1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7364"/>
    <dbReference type="EnsemblBacteria" id="ABF89114">
        <property type="protein sequence ID" value="ABF89114"/>
        <property type="gene ID" value="MXAN_7364"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7364"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="DIQMVAQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="12994" checksum="0C26271A1D5A337F" modified="2006-07-11" version="1">MMLVDDEDDIRTIGNLSLSRVGGWQTVLAASGAEALEKARTEKPDLILLDVMMPGMDGPTTFGRLRAEESTAHTPIIFMTAKIQKQEVARYLELGALGVIGKPFDPMTLPQEIRELVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB3</accession>
    <name>Q1CWB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92112">
        <property type="protein sequence ID" value="ABF92112"/>
        <property type="gene ID" value="MXAN_7197"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7197"/>
    <dbReference type="HOGENOM" id="CLU_3374780_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="34" mass="3666" checksum="3AB3507323AF5A48" modified="2006-07-11" version="1">MRQNEPDSEAAAPWLSAESPTDTGGAEFESGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB8</accession>
    <name>Q1CWB8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557111.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7192"/>
    <dbReference type="EnsemblBacteria" id="ABF87001">
        <property type="protein sequence ID" value="ABF87001"/>
        <property type="gene ID" value="MXAN_7192"/>
    </dbReference>
    <dbReference type="GeneID" id="41364365"/>
    <dbReference type="KEGG" id="mxa:MXAN_7192"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_1_7"/>
    <dbReference type="OMA" id="YWSLPGT"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="229" mass="26522" checksum="18BD5E66C089BE73" modified="2006-07-11" version="1">MSYTYEYPRPALTVDCVVFGLDDEDLKVLLIRRGVEPFAGRWALPGGFVRMEESLDDAARRELDEEAGIRPNHLEQLYTFGAPGRDPRGRVVTVAYFALVKLSDHVPHAATDARDAAWFSVWDTPKLAFDHVDVLGTALQRLKGKVRYQPIGFELLPPKFTLTQLQRLYEVILERELDKRNFRKKILAMDLLEELDEVEQDVSHRAARLYRFDHKKYKQLEKAGFNFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWE6</accession>
    <name>Q1CWE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7164"/>
    <dbReference type="EnsemblBacteria" id="ABF90362">
        <property type="protein sequence ID" value="ABF90362"/>
        <property type="gene ID" value="MXAN_7164"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7164"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610877_0_0_7"/>
    <dbReference type="OMA" id="CATNFSD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="313"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="443" mass="47499" checksum="BF88321E7A084A17" modified="2006-07-11" version="1">MISTPRPFEPGAAMSIVCATNFSDAARRASTLAAELARKAGTSLWLVHVLNPDSVRAFGKALLGSAEAVLSDETKRLEQLGVKVEPVLLTGEPAVMLEGFCREQGASLVVASRAADESPFGGEGGTVDRMAQSLTVPLLVMRDPAPLEAWVRGERSLKVFLGVDRSLPFEAARDWVLTLSKGGRVDVVGGRVYWPEEEARRLGLRQALAFGDALPELQHVLERECAELLAPLAQGGTPVRARVEMGVGRIADHLVDLAEQEHADLLVVGTHHRRALGRLWSVSRHALRLARMSVVCVPAQAMAVGTDTPLPEYREVMVATDFSETGNRAVAHAFALTAPGGTVHLVHATESKPSLEEEAQMREQLSALVPKSANDRSVRLNIIPGSKDVVATLAQTAERLGVSAIVMGTHGRSGWKRAVLGSVTQSLLLRTDRPVLVVRPPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX49</accession>
    <name>Q1CX49_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556830.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6910"/>
    <dbReference type="EnsemblBacteria" id="ABF88506">
        <property type="protein sequence ID" value="ABF88506"/>
        <property type="gene ID" value="MXAN_6910"/>
    </dbReference>
    <dbReference type="GeneID" id="41364092"/>
    <dbReference type="KEGG" id="mxa:MXAN_6910"/>
    <dbReference type="HOGENOM" id="CLU_130424_0_0_7"/>
    <dbReference type="OMA" id="GWTGNGE"/>
    <dbReference type="OrthoDB" id="1495967at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="180" mass="19682" checksum="3A58F2293B176873" modified="2006-07-11" version="1">MQGSSNETRSVLKLYKKEGNRLRYWEAWVHDGALTVHQGLVGETGEDHQLPLPPDEDPDMVIAEAAGPLVDQGYDEPEPTAMTTLIVQYTVEGKGTGHDVEKRVAVEELLTDALGWTGNGEVEGGELQAQQLRVYCRVMDADAGVRTAVEALDSEDLLEGATLLIARDDEEPRAVWPTQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC6</accession>
    <name>PAND_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">panD</name>
        <name type="ordered locus">MXAN_6830</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556755.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CXC6"/>
    <dbReference type="SMR" id="Q1CXC6"/>
    <dbReference type="STRING" id="246197.MXAN_6830"/>
    <dbReference type="EnsemblBacteria" id="ABF87899">
        <property type="protein sequence ID" value="ABF87899"/>
        <property type="gene ID" value="MXAN_6830"/>
    </dbReference>
    <dbReference type="GeneID" id="41364019"/>
    <dbReference type="KEGG" id="mxa:MXAN_6830"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_2_0_7"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="OrthoDB" id="1751990at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000307035" description="Aspartate 1-decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000307036" description="Aspartate 1-decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <sequence length="130" mass="14256" checksum="1BB9F898ADBADE29" modified="2006-07-11" version="1" precursor="true">MRRILFKSKIHRATVTQADLDYEGSVTIDRDLLRAADIVENEKVAVWNITQGTRLETYALEGEAGSGVICINGAAAHLNKPGDLVILATFAEVEEAEVANWKPTVVFVDKDNRVVPGQTKEIPGPQRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC8</accession>
    <name>Q1CXC8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6828"/>
    <dbReference type="EnsemblBacteria" id="ABF90042">
        <property type="protein sequence ID" value="ABF90042"/>
        <property type="gene ID" value="MXAN_6828"/>
    </dbReference>
    <dbReference type="GeneID" id="41364017"/>
    <dbReference type="KEGG" id="mxa:MXAN_6828"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025429_1_0_7"/>
    <dbReference type="OMA" id="LNCAYWP"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="99"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="505" mass="54693" checksum="5CC112D94C017CD9" modified="2006-07-11" version="1">MEVPLSGVRAHISSHLPSWRALLALGLLAAASVSCSKSSQDPAERRRLSLKPCRLEGLATQAQCGTYEVFEDRAARTGRKIPLRVVVVPALAAQPQPDPLVLLAGGPGQAASRSTQVLMAVERIRRKRDIVLVDQRGTGDSNPLNCKTDSPEEGLSARLEEGKAAEEVRKCREGWDADVRHYTTPVAMDDLDEVREALGYEKLNLWGVSYGTRAALVYMRQHPERVRTAILDGVAPMGLYLPLFAPRDAQQALDRLLANCEADAACTQAYPNLRPRTEALLTTLETTPARTQVAHPRTGVLEEVVLSRRAFLAQLFAQLYSPEMSSLVPLMLDRATQGDWSPFVALSVGLSENLGRTVSHGLYFAVVCAEDAPFYDEAALVRESQGTWFGPTMGREVLSVCADWPRGSLPQGYREPVVSSVPTLLLSGELDPVTPPAWAEEAKRTLSNSLHVVVPGVGHNTIGADCARTLMLDLLTQGSVEGLSSACGTNLTRPPFFTSFAGPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW1</accession>
    <name>Q1CXW1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ORF">MXAN_6645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556570.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6645"/>
    <dbReference type="EnsemblBacteria" id="ABF89906">
        <property type="protein sequence ID" value="ABF89906"/>
        <property type="gene ID" value="MXAN_6645"/>
    </dbReference>
    <dbReference type="GeneID" id="41363841"/>
    <dbReference type="KEGG" id="mxa:MXAN_6645"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_3_1_7"/>
    <dbReference type="OMA" id="VCAPQVP"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187891" evidence="4">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="26056" checksum="D82C69C7FC0C645B" modified="2006-07-11" version="1">MRHLFLLCAVSTLLSGVSAQADTVLVFAAVSTSDALQELAPAFTRTTGHAVEFSLGASSDLARQAVAGAPADVFLSADTAQMDAVEKAGLVAPSTRVDLLSNRLVVVVPVDAKSAPSSPAGLRGLKRLSLADPEAVPAGVYAKAWLVKAGLWKALAPNLVPALNVRAALAAVETGRVDAGVVYSTDAAHSKRVRVAFQVPEQDVPRIVYPAAALTKGAAPEAGRAFVRFLQSDAARKVFTRHGFGVPSARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY18</accession>
    <name>Q1CY18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6584"/>
    <dbReference type="EnsemblBacteria" id="ABF91442">
        <property type="protein sequence ID" value="ABF91442"/>
        <property type="gene ID" value="MXAN_6584"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6584"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048435_0_0_7"/>
    <dbReference type="OMA" id="WSSNTIA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="48591" checksum="51FE3267968A0EDE" modified="2006-07-11" version="1">MQVELASFGRSRRLSGLPRLTPPSCARLYLRAHRVSAACARKGDLVRRGTILFVLAVVTSVGCGDAADPDPGGCPETGTGTLELAIEGLPASANPHVIIRRGSESREVRAGGQLAGLAAGMWTLSPEPVAGSGGRVRAAYDAPARQVCVLDGEAAAAAIQYALIPSSQRLWLSTSNGAAEVEAFAAEELEVTGAPQATVRLGSSPGIPRASGLAFDRRGNLWVALGSGELRRYPAGDLGASGVKSPDVIMSGGVLSAGSPGPIAIAFDAAGDLWTSIGFSNTVIRFGAAQLVSGTAPAPQVVLSGLGDPSTLAFDAVGNLWVGDVTAGASRIHKVAASSLQASGAVTSVTSIEVLEAAPGRSFAGPAGLAFDGERNLWVSYGASGVVVRLTPDDQGGSGAVSVVPGIQIDAGGPKELAFDEGGGLWMAYNSGRISRLSPSQLSVSGAPTPDVVISSPDLGATHGVAVYPAPANLPLFHRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY43</accession>
    <name>Q1CY43_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556488.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6558"/>
    <dbReference type="EnsemblBacteria" id="ABF88545">
        <property type="protein sequence ID" value="ABF88545"/>
        <property type="gene ID" value="MXAN_6558"/>
    </dbReference>
    <dbReference type="GeneID" id="41363763"/>
    <dbReference type="KEGG" id="mxa:MXAN_6558"/>
    <dbReference type="HOGENOM" id="CLU_1238503_0_0_7"/>
    <dbReference type="OMA" id="VSIGMND"/>
    <dbReference type="OrthoDB" id="1290688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23134" checksum="350199923D32E237" modified="2006-07-11" version="1">MRRAGFAVLMLLAGCRPDPGVPDYTDQGYNRPDAGGEPNDEVLPGPYPYVEGQRRLGVGFYEGGRSQDIPVDNTTVHIYLYEGTLSLEPSTTRIEGRQSDLVVHAGKTWLGFGVHWNTPRNLDGWTTLHVSLNSADPGFANVSIGMNDDQSVQLPASQYGYTNDGQWHHLAIPLADFVAGGLQLNAVQAPFVFIAGAGPAADTLLLDNVYFTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY90</accession>
    <name>Q1CY90_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556441.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6510"/>
    <dbReference type="EnsemblBacteria" id="ABF92634">
        <property type="protein sequence ID" value="ABF92634"/>
        <property type="gene ID" value="MXAN_6510"/>
    </dbReference>
    <dbReference type="GeneID" id="41363718"/>
    <dbReference type="KEGG" id="mxa:MXAN_6510"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_0_0_7"/>
    <dbReference type="OMA" id="AMGKFNE"/>
    <dbReference type="OrthoDB" id="2051456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="16212" checksum="EF7C369067201427" modified="2006-07-11" version="1">MRVMVIVKATKNSEAGVMPGEQLMTEMGKYNEELMKAGVLLAGDGLHPSTKGKRIRFADGKKSVIDGPFAETKELIAGYWIWQVKSMEEAVEWARRCPPPMPGEESELEIRPVFEAEDFGAEFTPELRAQEEKLRAELEQKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYD2</accession>
    <name>Q1CYD2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trx</name>
        <name evidence="7" type="ORF">MXAN_6469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556399.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6469"/>
    <dbReference type="EnsemblBacteria" id="ABF86162">
        <property type="protein sequence ID" value="ABF86162"/>
        <property type="gene ID" value="MXAN_6469"/>
    </dbReference>
    <dbReference type="GeneID" id="41363675"/>
    <dbReference type="KEGG" id="mxa:MXAN_6469"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_7"/>
    <dbReference type="OMA" id="HEGAITK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="12090" checksum="D8E9F75B92802466" modified="2006-07-11" version="1">MTTNVISLDDAHFQREVLESSEPVLVDFTATWCPPCRALALVLDAIAADFRGRLKVTSLNVDDNPESAMRYGVRAVPALLLFKEGKVVRQMLGAQPRAKLEQELRTHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYD4</accession>
    <name>Q1CYD4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556397.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6467"/>
    <dbReference type="EnsemblBacteria" id="ABF92464">
        <property type="protein sequence ID" value="ABF92464"/>
        <property type="gene ID" value="MXAN_6467"/>
    </dbReference>
    <dbReference type="GeneID" id="41363673"/>
    <dbReference type="KEGG" id="mxa:MXAN_6467"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786897_0_0_7"/>
    <dbReference type="OMA" id="YMLARIQ"/>
    <dbReference type="OrthoDB" id="630189at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="36855" checksum="EAD6D7B5A56F3428" modified="2006-07-11" version="1">MKTRLWLLLVPALVAAGCGPIDEADEPVIDELTGQVLLEATTKYDMHRLLEDTDITGGQWITTAQVQAFLQQNNSFLANYRDPAFSNKTAAALIVERSKAFGISPLYMLARIQVESSLIQSGNSNNLAKATGCGCPDTSGCDAQYVGFGKQIDCSAKKLRGYLTDLDAGRATISGWRVGVTKSTSDPCSVRPANKATAALYTYTPWVGAYALQCGRTNVGGSSLVSVVYHRYESAYAWGSASGCYSETADTTVPELGCVQSSSDAMWRQCQSGAFTAGSTTKPTNCTASYGWCSSATLGRSVPPRTCVQSTGDQQWHQCGANRAWLSAPSAPISGAGPAGSCFAMYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV6</accession>
    <name>Q1CYV6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6291"/>
    <dbReference type="EnsemblBacteria" id="ABF92792">
        <property type="protein sequence ID" value="ABF92792"/>
        <property type="gene ID" value="MXAN_6291"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6291"/>
    <dbReference type="HOGENOM" id="CLU_3254460_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="42" mass="4809" checksum="F815032DC0D82350" modified="2006-07-11" version="1">MSVEDSRKDEGDAEPRKVKQAFSHEESVPSCREFQVLPSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ23</accession>
    <name>Q1CZ23_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556163.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6219"/>
    <dbReference type="EnsemblBacteria" id="ABF90818">
        <property type="protein sequence ID" value="ABF90818"/>
        <property type="gene ID" value="MXAN_6219"/>
    </dbReference>
    <dbReference type="GeneID" id="41363446"/>
    <dbReference type="KEGG" id="mxa:MXAN_6219"/>
    <dbReference type="HOGENOM" id="CLU_186063_0_0_7"/>
    <dbReference type="OMA" id="RNGPLIC"/>
    <dbReference type="OrthoDB" id="2096703at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187914" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="93" mass="10143" checksum="B96366980B8E0E4D" modified="2006-07-11" version="1">MPQNRATLMCIAALLMAGCGGAMDEATAEPATTESASQALYPEYDPDIHCLVSSQYVSCRSGPTMYAYYSPDWGYYINRDVCGRNGPLICPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB3</accession>
    <name>Q1CZB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6125"/>
    <dbReference type="EnsemblBacteria" id="ABF91379">
        <property type="protein sequence ID" value="ABF91379"/>
        <property type="gene ID" value="MXAN_6125"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6125"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011686_1_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="560" mass="63934" checksum="EC31374EE75CD207" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC4</accession>
    <name>Q1CZC4_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_6114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6114"/>
    <dbReference type="EnsemblBacteria" id="ABF90960">
        <property type="protein sequence ID" value="ABF90960"/>
        <property type="gene ID" value="MXAN_6114"/>
    </dbReference>
    <dbReference type="GeneID" id="41363349"/>
    <dbReference type="KEGG" id="mxa:MXAN_6114"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291301_0_0_7"/>
    <dbReference type="OMA" id="TRLWERC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1095" mass="117153" checksum="2EBCFB2645F6CE65" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE9</accession>
    <name>Q1CZE9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cytochrome c oxidase, subunit IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556038.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6089"/>
    <dbReference type="EnsemblBacteria" id="ABF91385">
        <property type="protein sequence ID" value="ABF91385"/>
        <property type="gene ID" value="MXAN_6089"/>
    </dbReference>
    <dbReference type="GeneID" id="41363325"/>
    <dbReference type="KEGG" id="mxa:MXAN_6089"/>
    <dbReference type="eggNOG" id="ENOG50339NS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738544_0_0_7"/>
    <dbReference type="OMA" id="MGIANES"/>
    <dbReference type="OrthoDB" id="1581236at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011743">
        <property type="entry name" value="Caa3_sub_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02229">
        <property type="entry name" value="caa3_sub_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16417" checksum="8BFBB0F9B0446D7B" modified="2006-07-11" version="1">MGIANESRQEEQNMREEHHGAGRYWLIWGLLLVLTVVTVVTGRIHIPTWGLVLALVIASTKGTLVLLYFMHLADHRGANRLVFAVSIIFVVLLLAIPLVDLGTRFRGATPPGSTYSDLQAIDIGADAEEGRYGGAIRKQGKTGEESGAPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ9</accession>
    <name>Q1CZQ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5979"/>
    <dbReference type="EnsemblBacteria" id="ABF91376">
        <property type="protein sequence ID" value="ABF91376"/>
        <property type="gene ID" value="MXAN_5979"/>
    </dbReference>
    <dbReference type="GeneID" id="41363218"/>
    <dbReference type="KEGG" id="mxa:MXAN_5979"/>
    <dbReference type="HOGENOM" id="CLU_1014994_0_0_7"/>
    <dbReference type="OMA" id="PDHKNRM"/>
    <dbReference type="OrthoDB" id="955547at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
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        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="158"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="29598" checksum="FF6DCE8B4AAE4832" modified="2006-07-11" version="1">MAREQAVKARNDRNGALVEAMLLAAMADGRVSQREMQTLLSRVLERPEFEGTRPDELNALVETSAARLSEAKNLDDVLASLRRRLPDHKNRMLAFGLAAAVALADQRATRDELGLLKTFQAALGISEDEVAQIIDVIENGGSLAEALGEPLERLFAEVMVLVSAADGKLQEAEARALVESFAADPLFENVSPERAQSFVSESVTALAAEGLPQRLHVLAHGLTTHAQRVKAFRLAIKIAHAGGAPSHPEQRILDMLQATFGLADDEVARLSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW0</accession>
    <name>Q1CZW0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555877.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5926"/>
    <dbReference type="EnsemblBacteria" id="ABF91649">
        <property type="protein sequence ID" value="ABF91649"/>
        <property type="gene ID" value="MXAN_5926"/>
    </dbReference>
    <dbReference type="GeneID" id="41363164"/>
    <dbReference type="KEGG" id="mxa:MXAN_5926"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_7"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="27565" checksum="57EBD126ECA58A0A" modified="2006-07-11" version="1">MTTARYCRFLHEGRAHHGRVEGSEVVVLTAAPWAGAKETGIHRSLSSLTLLVPSDASKVVCIGQNYRKHAEEMGKPVPPEPLIFTKPSTALNGTGSPIRIPKASQEVHYEAELALVIGEKLKNADESTAARAIWGLTCFNDVTARDVQRREIQHTRAKGYDTFACAGPWAVTGLSPADLRIVCRVNGQVRQDSRTSDMIFSPARLVSFISHIMTLLPGDIVSTGTPSGVGKLSAGDTVEVELEGIGTLVNPVEMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY9</accession>
    <name>Q1CZY9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555848.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5897"/>
    <dbReference type="EnsemblBacteria" id="ABF87180">
        <property type="protein sequence ID" value="ABF87180"/>
        <property type="gene ID" value="MXAN_5897"/>
    </dbReference>
    <dbReference type="GeneID" id="41363136"/>
    <dbReference type="KEGG" id="mxa:MXAN_5897"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_7"/>
    <dbReference type="OMA" id="FVDYYAE"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="357" mass="40525" checksum="9A8A1EBABAABB853" modified="2006-07-11" version="1">MPPTATIDPAGAVRPGEELDLPAVDAWLKAQVPTLEGTPEVTQYAGGASNWTYRLKYANRDLILRRPPAGTKAKSAHDMAREYTVQQALKPAYPVVPTMVGLCQDPAVLGSDFYVMERIEGLIPRKHLPRGLALDAKQTRTLCLNVIAKLVELHAVDPVAVGLTSLGKGPGYPTRQVEGWSARYEKARTWNVASFRYVRDWLKANTPADIATCVIHNDWRFDNVVLAPEEPTRIIGVLDWEMATLGDPLMDLGSALAYWVHADDDFLMRSTRRQPTHLPGMLRREEVVAYYLDQTKLKPANWTFYEVFGLFRLAVIAQQIYYRYHHKQTRNPAFKNFWVLVNYLGWRCHRLIRKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D016</accession>
    <name>Q1D016_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigE</name>
        <name evidence="9" type="ORF">MXAN_5870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5870"/>
    <dbReference type="EnsemblBacteria" id="ABF86483">
        <property type="protein sequence ID" value="ABF86483"/>
        <property type="gene ID" value="MXAN_5870"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5870"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_7"/>
    <dbReference type="OMA" id="HHVQAMK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="32238" checksum="AB58D570E74813BD" modified="2006-07-11" version="1">MAEVQRHPLLTREEELQLARHYKESGDVNAAYRLVASNLRLVVKLAHEYHRNPLSLLDLVQEGNIGLMQAVKKYDPERGVKLSSYAAWWIRAYILRYIMDNWKMVKLGTTEAQRKLFFKLRQEQEKLIAQGFEASPKLLAERLNVTEQDVVEMDQRLGHDEMSIDAPLGNDDDSRTTRADRYLPSNSMPADERLGAEQLKALFREKLSEFARTLEGKERFIFESRLVSDEPLTLQDIGDKYGVSRERARQIEAALINRMRDFMREQIPDFDLVASPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0A2</accession>
    <name>Q1D0A2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pilin regulatory protein PilR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pilR</name>
        <name evidence="8" type="ORF">MXAN_5784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555735.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D0A2">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5784"/>
    <dbReference type="EnsemblBacteria" id="ABF90941">
        <property type="protein sequence ID" value="ABF90941"/>
        <property type="gene ID" value="MXAN_5784"/>
    </dbReference>
    <dbReference type="GeneID" id="41363027"/>
    <dbReference type="KEGG" id="mxa:MXAN_5784"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="AYDYICK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="151"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="478" mass="51641" checksum="6D5906CC90FC0DD8" modified="2006-07-11" version="1">MTSVQGGDLGSRGHILVVDDELSMREYLELLLQREGYSVTSVASVKAACDVLALDGVDLVISDLKLGTGSGLDVLRAARARSASPEVVLITAYGTPAAAVEAMREGAYDYICKPFDNEELRLLVQKALEKRTLRQENSGLRARLFPGLDGAVGQSERMQAVWALVEKVASGRSTVLVTGESGTGKELVARAIHMRGTRAARPFLPFNCAALNEGTLESELFGHVKGAFTGATTDRSGLLVAAGDGTVMLDEVGEMPLATQVKLLRVLQERKVKPVGSAAEIPFQARVIAATNRRLEAEVKAGRFREDLFYRLNVITLELPPLRERSGDVSLLANYFLSRLSEELGRPGLRFSPETLGLLERYPFPGNVRQLQNMVERAATLSDSDLLGPSTLPPAVRGDTDPAVRPVEGSEPGLVAGFNLERHLDDSERRYLVAAMKQAGGVKTRAAELLGLSFRSFRYRLAKHGLTDDLEPGSASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0B4</accession>
    <name>Q1D0B4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type IV pilus secretin PilQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pilQ</name>
        <name evidence="9" type="ORF">MXAN_5772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555723.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5772"/>
    <dbReference type="EnsemblBacteria" id="ABF88494">
        <property type="protein sequence ID" value="ABF88494"/>
        <property type="gene ID" value="MXAN_5772"/>
    </dbReference>
    <dbReference type="GeneID" id="41363015"/>
    <dbReference type="KEGG" id="mxa:MXAN_5772"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006756_0_0_7"/>
    <dbReference type="OMA" id="PRILNRQ"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013355">
        <property type="entry name" value="Pilus_4_PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02515">
        <property type="entry name" value="IV_pilus_PilQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="8">
        <location>
            <begin position="504"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="901" mass="95731" checksum="A27287E31548C757" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K8</accession>
    <name>Q1D0K8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555630.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5677"/>
    <dbReference type="EnsemblBacteria" id="ABF88749">
        <property type="protein sequence ID" value="ABF88749"/>
        <property type="gene ID" value="MXAN_5677"/>
    </dbReference>
    <dbReference type="GeneID" id="41362921"/>
    <dbReference type="KEGG" id="mxa:MXAN_5677"/>
    <dbReference type="HOGENOM" id="CLU_064717_0_0_7"/>
    <dbReference type="OMA" id="GFIWYYS"/>
    <dbReference type="OrthoDB" id="1567480at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025513">
        <property type="entry name" value="DUF4401"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14351">
        <property type="entry name" value="DUF4401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4401" evidence="2">
        <location>
            <begin position="43"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="365" mass="38608" checksum="C4F8C8DF3E6075FC" modified="2006-07-11" version="1">MALRPSLQDVLNALQAEGQLEPDSVDRARVALEAHQRQSVAVPWFVKAFAGVGAWLSAIFVLSFFACAGLWEEQVVMGVVGLGLCAGATMLRRTLRGVFVEQLALAQCLAGAAMASASFGIETENENVAATLVLVISGVLLFVYPDAILRFLSTLGVVGAAGFLAWHVVGGFALDLLILGCAALMYFLFLEQARLRRGTPGELVGPVAFALACAIPGVLLARGMRDVARHLFDTVSALPDAVLTLGLTVLTLYTAWRVLRELALEPTGVAGAAVFAALTLVAVLTPHTPAVITAVGMLVLGFHRRSNVLLGLAVAYLLASGSWYYYDLGLTLLAKSLALMGSGLVFLGLRSFLLRRFPAPASEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D143</accession>
    <name>Q1D143_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat (Twin-arginine translocation) pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555445.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5487"/>
    <dbReference type="EnsemblBacteria" id="ABF87074">
        <property type="protein sequence ID" value="ABF87074"/>
        <property type="gene ID" value="MXAN_5487"/>
    </dbReference>
    <dbReference type="GeneID" id="41362741"/>
    <dbReference type="KEGG" id="mxa:MXAN_5487"/>
    <dbReference type="eggNOG" id="COG2960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044709_1_0_7"/>
    <dbReference type="OMA" id="ADTWTRM"/>
    <dbReference type="OrthoDB" id="497249at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011447">
        <property type="entry name" value="DUF1552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07586">
        <property type="entry name" value="HXXSHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188141" evidence="1">
        <location>
            <begin position="35"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="478" mass="51541" checksum="2E35B709AB68D4AF" modified="2006-07-11" version="1">MLRELSRRSLLQALAGSTAALPLANLLGTTDAYAQGTAPPLRFVALFTSHGCLPELWNPQGSETNFTLDFPDSMLAPLQPHRDRLLVLDGLDYQVLYEQGLTGHEGGPVTFLTGSKVNTGSGDHLPESASLDQVLGNHIGGGTRFRSLQLNAWEQFGGQHVYNSISFTANGSRVPFERDPANVYQRLFGDAPSPTADPAQVASNRARRKSLLDFLMKDATRLRNRLAGAERQKLETHLEALRDIERRLGALAVDPTPLPKQQSGEAACGGGAAPPSYGLGGLGNLNNMPTLTRLHMDLIARAFACDLTRVVTMTIPGPSMPWLGIHEDTHNDIAHLLDVQEEPRRTTIRGKMVQVQRWYAEQLAYLMTQLASIPEGSGTALDNTLIYWGNELGDASGHMNVRVPTVLAGGAGGRFRMGRFLRVRPAGSNPLGGWAGPGTRLSGAVAHNKLLVSIARAFGVNVNTFGHPDYTGELPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D176</accession>
    <name>Q1D176_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M36 (Fungalysin) family</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555412.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5454"/>
    <dbReference type="EnsemblBacteria" id="ABF87161">
        <property type="protein sequence ID" value="ABF87161"/>
        <property type="gene ID" value="MXAN_5454"/>
    </dbReference>
    <dbReference type="GeneID" id="41362711"/>
    <dbReference type="KEGG" id="mxa:MXAN_5454"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002091_0_0_7"/>
    <dbReference type="OMA" id="DPWLPAN"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188143" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="1512"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1636" mass="173497" checksum="26DA1D680028B73C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1J3</accession>
    <name>Q1D1J3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555295.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5330"/>
    <dbReference type="EnsemblBacteria" id="ABF91332">
        <property type="protein sequence ID" value="ABF91332"/>
        <property type="gene ID" value="MXAN_5330"/>
    </dbReference>
    <dbReference type="GeneID" id="41362599"/>
    <dbReference type="KEGG" id="mxa:MXAN_5330"/>
    <dbReference type="eggNOG" id="COG3236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084247_1_0_7"/>
    <dbReference type="OMA" id="WMMAAKA"/>
    <dbReference type="OrthoDB" id="1726046at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="19538" checksum="E569DEE8075A2E90" modified="2006-07-11" version="1">MSEAEQQRFTFFWQAHSPFSQWHPSDFTVDGVRYVCAEQYMMAGKARLFGDNEALASILSSKSPKTHKALGRKVRDFDNTRWEKARERIVYEGNRAKFTQSPELLKALLATAGTELVEASPVDRIWGVGLDEEDPRILHPAKWRGLNLLGKVLTKLREDLLAEGVTEASSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U0</accession>
    <name>Q1D1U0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555198.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5231"/>
    <dbReference type="EnsemblBacteria" id="ABF91022">
        <property type="protein sequence ID" value="ABF91022"/>
        <property type="gene ID" value="MXAN_5231"/>
    </dbReference>
    <dbReference type="GeneID" id="41362512"/>
    <dbReference type="KEGG" id="mxa:MXAN_5231"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920787_0_0_7"/>
    <dbReference type="OMA" id="VGHFYEG"/>
    <dbReference type="OrthoDB" id="1238974at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="32104" checksum="B79EEFAD82922DCD" modified="2006-07-11" version="1">MRRDVAVLLENAPPRRRALSEAAFVFLAVLGPSSAGPAGRVVLAVLAVALLAWGLALLRPWEATRAGAWLGVLGLLVALGGTGAGAWVATAAEQEKGISLSMAPLCIRALGMILLVAVLVWRDRQGPAQVGLAREGWAKELLLGVPVLVATYAVHIAASVPMAAVAVALKLADKEMLARKGLATALIDTGLDVPAFAAIMVLVTGFEEFVFRGFLVPRLRVVMGRWVPAVLVAAVLFSVGHFYEGTLAVFQTFVMGAWFGFVFWFRGRLLPLVVAHAAFNTISFALVMWLSKSGYLDKLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V7</accession>
    <name>Q1D1V7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555182.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5214"/>
    <dbReference type="EnsemblBacteria" id="ABF92825">
        <property type="protein sequence ID" value="ABF92825"/>
        <property type="gene ID" value="MXAN_5214"/>
    </dbReference>
    <dbReference type="GeneID" id="41362496"/>
    <dbReference type="KEGG" id="mxa:MXAN_5214"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079078_0_0_7"/>
    <dbReference type="OMA" id="WNIPDGF"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="33299" checksum="C2C4A93ABF8C82A3" modified="2006-07-11" version="1">MSTAPYPIGSPGSPWGEAEVTTWRSRQTRKRSYAADVLSAIERLRARFDVVQYGLLDYPPDTYPLFALASRDWRDGLPVALVTGGVHGYETSGVHGALQFVERHAAGYAGRFNLLVVPCVSPWAYERIQRWNMNAIDPNRSFREPSPAEESAALMRLVAPLRDRVLVHVDLHETTDSDEAEFRPALAARDGKPFEPDHTPDGFYVVGDTENPRLDFQQAVIAAVAKVTHIAPPDADGKIIGSPVVAPGVIHYALRQLGLCAGITRARYVTTTEVYPDSPRATPAQCSDAQVAAVTAALDYALAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2C4</accession>
    <name>Q1D2C4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cell wall surface anchor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555020.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5044"/>
    <dbReference type="EnsemblBacteria" id="ABF90900">
        <property type="protein sequence ID" value="ABF90900"/>
        <property type="gene ID" value="MXAN_5044"/>
    </dbReference>
    <dbReference type="GeneID" id="41362329"/>
    <dbReference type="KEGG" id="mxa:MXAN_5044"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160097_0_0_7"/>
    <dbReference type="OMA" id="VTATIHF"/>
    <dbReference type="OrthoDB" id="413616at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="3">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="239" mass="24671" checksum="50E1238A8BACF261" modified="2006-07-11" version="1">MAEGPHTVTATATPPGGNPGPTSTPVTFTITLTATEPPVITGPADGAVLNTSTPPLSGTSAPGTVVTVYEGDTVLCTTTTNDVGAWTCTPAQPLEDGPHTVTATATDSEGRTSEPSAPSEFIIDTQEPDTRISRTPPSRGGNRTATFEYGASEEDVTYECSLNGGPFEPCRDSYDVGEGQHTLRVRATDRAGNVDSTPAAYSWTVELTRAFAGGGCSTAPAASWLALLGLLGLRRRKRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Q7</accession>
    <name>MURA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="1">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA</name>
        <name type="ordered locus">MXAN_4909</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554890.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D2Q7"/>
    <dbReference type="SMR" id="Q1D2Q7"/>
    <dbReference type="STRING" id="246197.MXAN_4909"/>
    <dbReference type="EnsemblBacteria" id="ABF90980">
        <property type="protein sequence ID" value="ABF90980"/>
        <property type="gene ID" value="MXAN_4909"/>
    </dbReference>
    <dbReference type="GeneID" id="41362197"/>
    <dbReference type="KEGG" id="mxa:MXAN_4909"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_7"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000023057" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="420" mass="44372" checksum="E5AC311949189631" modified="2006-07-11" version="1">MDKIVIKGGQALHGEVQASGAKNAALPILASALLADGTSTYRNVPALADVATMLKVLRTMGCDAERDSETTDVCRVGVNGHITPEAPYDLVKTMRASVLVLGPLVARFGRARVSMPGGCAIGARPIDQHLKGLKALGADIHLTEGYVEATAKQLKGGTVNFDVITVTGTENVMMAAVLAKGRTLMENCAREPEVEELAKVLNKMGARIEGAGTSSITIEGVDGLKPVEHAILPDRIEAGTLLVAAAISGGDVLVKRVVPEHMDALVEKLREAGCTITTEGSGLRCKAPQRLDAVNITTTEHPGFPTDMQAQLMALMSVSQGTSVISENIFENRFMHVPELHRLGADITIQGPTAVVKGVKGLSGAPVMATDLRASASLILAGLRAEGRTDVSRVYHLDRGYERLERKLSALGADIRREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D313</accession>
    <name>Q1D313_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OmpA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554785.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4799"/>
    <dbReference type="EnsemblBacteria" id="ABF92253">
        <property type="protein sequence ID" value="ABF92253"/>
        <property type="gene ID" value="MXAN_4799"/>
    </dbReference>
    <dbReference type="GeneID" id="41362098"/>
    <dbReference type="KEGG" id="mxa:MXAN_4799"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020578_0_0_7"/>
    <dbReference type="OMA" id="LEMFALA"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188181" evidence="6">
        <location>
            <begin position="25"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="7">
        <location>
            <begin position="489"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="615" mass="66082" checksum="AA9274D25DFDCB1E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D356</accession>
    <name>Q1D356_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554742.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4755"/>
    <dbReference type="EnsemblBacteria" id="ABF90750">
        <property type="protein sequence ID" value="ABF90750"/>
        <property type="gene ID" value="MXAN_4755"/>
    </dbReference>
    <dbReference type="GeneID" id="41362054"/>
    <dbReference type="KEGG" id="mxa:MXAN_4755"/>
    <dbReference type="HOGENOM" id="CLU_141051_0_0_7"/>
    <dbReference type="OMA" id="GAYALWF"/>
    <dbReference type="OrthoDB" id="1924913at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13150" checksum="8D2E88D915294905" modified="2006-07-11" version="1">MGHQGLEQHRRILGILFIVINGLSVLIAVGVMLFFGAMGGMLPSAKPEERALIVAVGMGVGGCLALLGLPGVITGFGLLYRKAWSRTLTLVLGILAIPNVPLGTALGAYALWFYLQPGSDQVFDT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D385</accession>
    <name>LPXD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxD</name>
        <name type="ordered locus">MXAN_4726</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF87897" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87897.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043612861.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D385"/>
    <dbReference type="SMR" id="Q1D385"/>
    <dbReference type="STRING" id="246197.MXAN_4726"/>
    <dbReference type="EnsemblBacteria" id="ABF87897">
        <property type="protein sequence ID" value="ABF87897"/>
        <property type="gene ID" value="MXAN_4726"/>
    </dbReference>
    <dbReference type="GeneID" id="41362025"/>
    <dbReference type="KEGG" id="mxa:MXAN_4726"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_7"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264397" description="UDP-3-O-acylglucosamine N-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="349" mass="36382" checksum="7858A33B44FE3FB0" modified="2006-12-12" version="2">MPRQLGELAAHVGGELLGDPSQLIHGLNGLEEAGPGDVSFYGNPRYRRQFEATRASAVLVGADVPPREGVALVRVANPHLAYAKLLRLFHAPERPAAGVRPGAWVHPEATVHPEAVLLPGASVDRGGRVGARTVLYPGAYVGEQAEVGEDCVLYPNVTVRERCIVGARVILHASSVVGADGFGFAFNPEGEAGPEHFKIPQVGIVRIEDDVEVGACTCIDRATVGETVVGRGAKLDNLVQIAHNVRVGPLSLICAQAGVSGSAEVGTGVVLAGQVGVVGHIRVGDLAKVGAQSGVAHDVPDGQVVSGSPAVPHREWLRASAAAGQMADLLKEVRALRRRVETLEKEKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D390</accession>
    <name>Q1D390_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554708.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4721"/>
    <dbReference type="EnsemblBacteria" id="ABF90195">
        <property type="protein sequence ID" value="ABF90195"/>
        <property type="gene ID" value="MXAN_4721"/>
    </dbReference>
    <dbReference type="GeneID" id="41362020"/>
    <dbReference type="KEGG" id="mxa:MXAN_4721"/>
    <dbReference type="HOGENOM" id="CLU_1683606_0_0_7"/>
    <dbReference type="OMA" id="VYLQEVQ"/>
    <dbReference type="OrthoDB" id="1564598at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="17083" checksum="3058E225B54B9EE9" modified="2006-07-11" version="1">MDRFHQKAWALLGLGVLGSTGCAHQARLAERQGVEAEKCELVHRLLREPVPSQVVREVVAAGRDEPAPVVVYVRRPEEAMLERFFSGDAPSCGDATFKVVQENVLDAVVVYLQEIQDGYAYDAHRASHDELSLEGKPQGLLKRKGPEWVAIPGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3A4</accession>
    <name>Q1D3A4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4707"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90734">
        <property type="protein sequence ID" value="ABF90734"/>
        <property type="gene ID" value="MXAN_4707"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4707"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057057_0_0_7"/>
    <dbReference type="OMA" id="VLTSFHQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="34343" checksum="36A9084C44384D5F" modified="2006-07-11" version="1">MLLVRPDNRVGEALLTTPLMRTLKAHLQSAPEVHVLVHAKVARVLNGHPDADVIIPFDRRRIWMGPLAPGIAALRRARYDVVVDCANWESPSVTSALVSRLAGPEAVVIGPDLWPVSRLHSLPVPARTDTRNEAVQRTHLLTPLTNGAVARVLSFREPSVGPAIRAYLDALAGKPFAVINPGGRLGPRRIPPAAFAAAARALVALGRTPIVTWGPGEEALARGVVEAAPGSELAPASNLDELAALMRAAGFTLCNNTGPMHLSVAVGAPTLAFFLRMDMERWGHAYAPHRMVDLTPLVDGAGGQGLEERAAEEVRTFAASLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B1</accession>
    <name>Q1D3B1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554687.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4696"/>
    <dbReference type="EnsemblBacteria" id="ABF88442">
        <property type="protein sequence ID" value="ABF88442"/>
        <property type="gene ID" value="MXAN_4696"/>
    </dbReference>
    <dbReference type="GeneID" id="41361995"/>
    <dbReference type="KEGG" id="mxa:MXAN_4696"/>
    <dbReference type="HOGENOM" id="CLU_1576822_0_0_7"/>
    <dbReference type="OMA" id="APVVETC"/>
    <dbReference type="OrthoDB" id="2009509at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="18478" checksum="F0B22E96B512E5AA" modified="2006-07-11" version="1">MGEDGSPVTSPSRPAFPTAFITALRELEPRPAAMLTLRLVEGRSREACATHYGIPAQAFSVLLLRAAIALALHRGAPAREPASENEEAAWARMLADALERQDAKFPAALAPVVETCRELQTLAPQVATGLETAEREARASPQRRREEWLRRLAVALLLAMTAWLYLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3F0</accession>
    <name>Q1D3F0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4657"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86632">
        <property type="protein sequence ID" value="ABF86632"/>
        <property type="gene ID" value="MXAN_4657"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4657"/>
    <dbReference type="HOGENOM" id="CLU_1068860_0_0_7"/>
    <dbReference type="OMA" id="YYRLAYF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188189" evidence="2">
        <location>
            <begin position="47"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="31223" checksum="BFF8BA06DDA52F2B" modified="2006-07-11" version="1">MTRPTRMPARRPRRMTSKTSRFPVSRVVAARTALLCVLLASVPAAAEQELPIYPGTIHTRIGNDLVIGGEYYRLAYFTTPDPMEKVAAYFARKWQEEGYPTVVEGDMQDEGVVSALYTREGLQRGVVLRKHLGKTVGFTALRDLWVRPPKKPAPGLVALEGALYSQDLATRDDPGGSQSRTTLVTGELTKVQQQVNAELERRGYAPVRQSALKMGGGTQLTMEHARKGEQVVTTLSPTDEGVTAVVQMWIGSDRPDAVPNDDAVRQSREAYERDQAQKKEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3P4</accession>
    <name>Q1D3P4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554556.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4561"/>
    <dbReference type="EnsemblBacteria" id="ABF85932">
        <property type="protein sequence ID" value="ABF85932"/>
        <property type="gene ID" value="MXAN_4561"/>
    </dbReference>
    <dbReference type="GeneID" id="41361862"/>
    <dbReference type="KEGG" id="mxa:MXAN_4561"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345075_0_0_7"/>
    <dbReference type="OMA" id="WDQAIED"/>
    <dbReference type="OrthoDB" id="127223at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188197" evidence="3">
        <location>
            <begin position="31"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="838" mass="90326" checksum="8646D014955096EA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q4</accession>
    <name>Q1D3Q4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554546.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4551"/>
    <dbReference type="EnsemblBacteria" id="ABF90539">
        <property type="protein sequence ID" value="ABF90539"/>
        <property type="gene ID" value="MXAN_4551"/>
    </dbReference>
    <dbReference type="GeneID" id="41361852"/>
    <dbReference type="KEGG" id="mxa:MXAN_4551"/>
    <dbReference type="HOGENOM" id="CLU_1979133_0_0_7"/>
    <dbReference type="OMA" id="ELHFEHI"/>
    <dbReference type="OrthoDB" id="1772878at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13948" checksum="A777DC53A2B9A5C3" modified="2006-07-11" version="1">MTPILYVPELHFAQVQEWLQFWNDAVTPETLPQTGFIIPGKAAGFLYRTDSSLAMIETLVAAPGLSKEERSAAVDLVVAAISEESTRLGFQVLVGYTQLDAVVKRAERHGFIYVDGGFHVIAKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3X7</accession>
    <name>Q1D3X7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554473.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4476"/>
    <dbReference type="EnsemblBacteria" id="ABF89621">
        <property type="protein sequence ID" value="ABF89621"/>
        <property type="gene ID" value="MXAN_4476"/>
    </dbReference>
    <dbReference type="GeneID" id="41361787"/>
    <dbReference type="KEGG" id="mxa:MXAN_4476"/>
    <dbReference type="eggNOG" id="ENOG502ZEDQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114453_0_0_7"/>
    <dbReference type="OrthoDB" id="1571502at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18469" checksum="C57717E2262720C6" modified="2006-07-11" version="1">MSDERAWKGNVKARLYERVREHGYDSLTAFAKARPAVPLYLLAEELGKDDVAAVQVLSGLLGEAEQRKQVTRFVRDVLVRELSEGLPNGWPAVLNDANRFEVAKALSSWIAYTPDTHQDRARQVSAALLAKPPPPGWRPLAPDDELLLTLLPDEEVWTSSPGEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D496</accession>
    <name>Q1D496_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554355.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4354"/>
    <dbReference type="EnsemblBacteria" id="ABF91627">
        <property type="protein sequence ID" value="ABF91627"/>
        <property type="gene ID" value="MXAN_4354"/>
    </dbReference>
    <dbReference type="GeneID" id="41361666"/>
    <dbReference type="KEGG" id="mxa:MXAN_4354"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_4_0_7"/>
    <dbReference type="OMA" id="CPIHKLM"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14620" checksum="666C2D0676083FF1" modified="2006-07-11" version="1">MTTHSQTEKPGAFRQVLKTGTHTLHADVAPALGGEDSAPGPHDYFDAALAACKALTATWYAKRHGLALERVETHVERDDSRERQGTYTLKVKLAFHGALSPADKQRLYNAVAQCPIHKLMTTSTVDIVTEPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S3</accession>
    <name>Q1D4S3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554178.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4175"/>
    <dbReference type="EnsemblBacteria" id="ABF92299">
        <property type="protein sequence ID" value="ABF92299"/>
        <property type="gene ID" value="MXAN_4175"/>
    </dbReference>
    <dbReference type="GeneID" id="41361493"/>
    <dbReference type="KEGG" id="mxa:MXAN_4175"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_7"/>
    <dbReference type="OMA" id="TGKIQPE"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188228" evidence="2">
        <location>
            <begin position="22"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="45"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="3">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="419" mass="44267" checksum="B30DA8F342DE6064" modified="2006-07-11" version="1">MKWWKGAIAGALFLGAAAITAGGLKDRPPPSLEVQLSKARKGSITRTITGAGKVQAATTVKISSSLSGDLVELAVKDGEAVTKGQVLGRIDPRLYQAAHKQALASLNASRADVQVAEVEVGRAQLELARAEDLAKKGLSSAAEVDTARATKNTGDARLASAKQMLARNMAIVDQAQTDLTRTTLVSPIDGNVIELSREVGERVRGSDLSEDVVMTIAALSAMEVKFEVGEHEVVHLKPGQPAEITLDALEGQTYSGSVVEIAQKALIKNEGTEAEVTSFPITVALDTRPPNVLPGMSSEVRISAETHNDVVLVPIQAVTVRSERSLPDYKAPIEGGGLTAKRTESLAKVVFVVDSSNKAQVRRVQTGIASDTELEIVSGLNDGDRVIEGPYRTLSKELNDGDIVREPEQGAGMKGGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4X9</accession>
    <name>Q1D4X9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase orf2, IS66 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554122.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4116"/>
    <dbReference type="EnsemblBacteria" id="ABF90248">
        <property type="protein sequence ID" value="ABF90248"/>
        <property type="gene ID" value="MXAN_4116"/>
    </dbReference>
    <dbReference type="GeneID" id="41364653"/>
    <dbReference type="KEGG" id="mxa:MXAN_4116"/>
    <dbReference type="HOGENOM" id="CLU_023034_7_4_7"/>
    <dbReference type="OrthoDB" id="768876at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-IS66" evidence="2">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="21602" checksum="9BB5D332881E12A3" modified="2006-07-11" version="1">MPRELPQDHFCPWREEAEELKERLTSLEAKMATLERHVFSRRTEKLPTVASELRGDADTTAAQAEAAKKKRRERAARKAEQAPAREIRHAVPAEERCCPACGGEDLRPLGKGRASVLFEHIPARFERQVHVQEVLACTCGKGVVTAPPPPRVVDRGEYGPGFIAHVAHVEVRGRHAAAPAGPAGGEKRRAHESQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Y4</accession>
    <name>Q1D4Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554117.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4111"/>
    <dbReference type="EnsemblBacteria" id="ABF90069">
        <property type="protein sequence ID" value="ABF90069"/>
        <property type="gene ID" value="MXAN_4111"/>
    </dbReference>
    <dbReference type="GeneID" id="41361441"/>
    <dbReference type="KEGG" id="mxa:MXAN_4111"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_5_1_7"/>
    <dbReference type="OMA" id="YQSHGAH"/>
    <dbReference type="OrthoDB" id="833478at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="207"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="34034" checksum="4A22F0BCE0CDC794" modified="2006-07-11" version="1">MSTTTQVSVPTSPRTTSRPRTLESVHGGGELHWVGDGFRVHTLVPSGGLRQERTSPFLLLDYHPPHDYPALAKGQRGVGWHPHRGFETVTLAFEGHVAHRDNAGHSGVISPGDVQWMTAASGILHEEYHEHDFSRRGGTFHMLQLWVNLPRQHKMSAPGYQPITKEQIPVVPVQGGGEATEHSRVRIIAGSYGDAKGPARTFTPISMLDVKVRAGEDFNLSLPSNHNALVLVANGRVTVDAESIRSGELAVFANDGETLSLRAEEDTHFIVLAGEPIHEPIAHTGPFVMNNHREIIQAIHDFESGAFGGIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5R6</accession>
    <name>Q1D5R6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553837.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3825"/>
    <dbReference type="MEROPS" id="C26.001"/>
    <dbReference type="EnsemblBacteria" id="ABF91287">
        <property type="protein sequence ID" value="ABF91287"/>
        <property type="gene ID" value="MXAN_3825"/>
    </dbReference>
    <dbReference type="GeneID" id="41361157"/>
    <dbReference type="KEGG" id="mxa:MXAN_3825"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_3_1_7"/>
    <dbReference type="OMA" id="TSMLHWH"/>
    <dbReference type="OrthoDB" id="1242215at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="25765" checksum="5DD04520B89CC846" modified="2006-07-11" version="1">MRAVVFQHEEHEGPGLLGPVLQAAGFTLVNRFRTVRREDVDAELLVVMGGRMAVYESEQHPFLRQELGILMERLAYERPCLGFCLGAQMLAAAAGADVFPGKNGFEVGVGPVRWTPEAQKDPVLSGARPRTVVAHWHGDSYAPVPDATLLASTDRYTQQAFRLGTSYGFQFHLELTASELGRWIDIEADSLQQRGKNLQELKAQLPKLKAAEADNTEVLHRLAHHFARVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5T5</accession>
    <name>Q1D5T5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3806"/>
    <dbReference type="EnsemblBacteria" id="ABF85878">
        <property type="protein sequence ID" value="ABF85878"/>
        <property type="gene ID" value="MXAN_3806"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3806"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244221_0_0_7"/>
    <dbReference type="OMA" id="PACESAR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26763" checksum="90B758CC6DC8C88A" modified="2006-07-11" version="1">MLPSTRLHLVYFTGDVRGNARTDSGGQVMLRVMILIPLLLVGAACQRPLTPEEDRAQALEIVRSRASVAEREGCPAEAIPERQAQLENFFIYCDARLSWCAKQCFKSDATACYALAVIFQNDDATDQLAEPLFYRSCTQGVISGCSNRAAGLQIQQQTDDTAMTCAVRTFEKTCALRDPWGCAMHGFNLVQGTHTPRDLKKAREVLGQSCRDGEDDPACQAARGLQSQLDAFDLEQATEPRPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X9</accession>
    <name>RNC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">MXAN_3762</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D5X9"/>
    <dbReference type="SMR" id="Q1D5X9"/>
    <dbReference type="STRING" id="246197.MXAN_3762"/>
    <dbReference type="EnsemblBacteria" id="ABF91367">
        <property type="protein sequence ID" value="ABF91367"/>
        <property type="gene ID" value="MXAN_3762"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3762"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_7"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000094120" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="172"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="260" mass="28550" checksum="BCDAA56B179E54B4" modified="2006-07-11" version="1">MMRLSGADKMSPSERVQLLESRLGLSFSRMETALEALTHKTYVNETRDKELKDNQRLEFLGDSVVNLAVSHRLMARCPGLPEGDLTKMRARVVNEDGLARVARTIPLGDLLLLGRGELMSGGREKNSVLADALEAVFGAVFLTSGLDAAVTLVDRYFADLLDEVSSGQGRLDYKTLLQEMAHERLKLQPRYRVVSESGPEHSKVFEVELMLGETAFARATGRSKKEAEQSAAQATLEKLREDAACPTSPPPGTPRHDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D621</accession>
    <name>Q1D621_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553733.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3716"/>
    <dbReference type="EnsemblBacteria" id="ABF90000">
        <property type="protein sequence ID" value="ABF90000"/>
        <property type="gene ID" value="MXAN_3716"/>
    </dbReference>
    <dbReference type="GeneID" id="41361049"/>
    <dbReference type="KEGG" id="mxa:MXAN_3716"/>
    <dbReference type="eggNOG" id="ENOG503316B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102153_0_0_7"/>
    <dbReference type="OMA" id="HAYRSAP"/>
    <dbReference type="OrthoDB" id="1628716at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="24669" checksum="0D40AAC3FE165B5A" modified="2006-07-11" version="1">MAGTRPGEAGDEDTSSLGSDAVMFRAPLLPCPAASPAGQRNRRTNMATHKVGGEVDALCTRCKLTLAHTILAMVGTKIARVRCNTCGGDHAYRAAPGATDRPASSTTRTARSSSSSSSSASKAEKVIISFEEQLAGKDVANAPRYSPKDTYKVDQVIQHPTFGTGYVSAVRGDKVDITFRTDTKTLVHGRGGGPVEKPVFNPPNRQVTGPADKPLPVGDSAEPAPADGAEPPPASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D3</accession>
    <name>Q1D6D3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Z1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553625.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3602"/>
    <dbReference type="EnsemblBacteria" id="ABF90915">
        <property type="protein sequence ID" value="ABF90915"/>
        <property type="gene ID" value="MXAN_3602"/>
    </dbReference>
    <dbReference type="GeneID" id="41360947"/>
    <dbReference type="KEGG" id="mxa:MXAN_3602"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007800_1_0_7"/>
    <dbReference type="OMA" id="LVHVTRF"/>
    <dbReference type="OrthoDB" id="323445at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018310">
        <property type="entry name" value="Put_endonuclease_Z1-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10593">
        <property type="entry name" value="Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Z1" evidence="2">
        <location>
            <begin position="445"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="951" mass="106779" checksum="53376FAF86963B88" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Q2</accession>
    <name>Q1D6Q2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553507.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3475"/>
    <dbReference type="EnsemblBacteria" id="ABF88718">
        <property type="protein sequence ID" value="ABF88718"/>
        <property type="gene ID" value="MXAN_3475"/>
    </dbReference>
    <dbReference type="GeneID" id="41360822"/>
    <dbReference type="KEGG" id="mxa:MXAN_3475"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128031_0_0_7"/>
    <dbReference type="OMA" id="GSREWID"/>
    <dbReference type="OrthoDB" id="1936597at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="15811" checksum="AFCA13D20CC01583" modified="2006-07-11" version="1">MAKFPSKEWVDEAVRLTNEDPECAMAGKGWKGDFGAVVEAEPGKLAKAFVVHVVPGDCRIEKARVLADPDDLDELEPVYLARAPYSVWKQLLKGTLDPVEAVLKRRISMKGDLQPLIERMKYKGIADRVFAQLQTQFIDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Q6</accession>
    <name>Q1D6Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553503.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3470"/>
    <dbReference type="EnsemblBacteria" id="ABF89978">
        <property type="protein sequence ID" value="ABF89978"/>
        <property type="gene ID" value="MXAN_3470"/>
    </dbReference>
    <dbReference type="GeneID" id="41360818"/>
    <dbReference type="KEGG" id="mxa:MXAN_3470"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087262_0_0_7"/>
    <dbReference type="OMA" id="VVRYRMN"/>
    <dbReference type="OrthoDB" id="1785930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30515" checksum="78BA7D56218EAA11" modified="2006-07-11" version="1">MRTVTLMGILATLATGCATTGAPLEPWLDSYSLRYRSASPPAFPRESLSKQVATANREAPAARPDTVAARPAKASGGKSRATPARATRPTPVASDARAKVVTTARSLVGKTQVALNGRKYPSDCTGLIEGVYAQAGVTFRGTVQPGDNGVTAMYRFARSRGRVYQEERPTPGDLVFFNETYDQNRDGRRNDGLTHVGIVENVSASGTVTVIHRVRRGVVRYRMNLERPHLRRDPKTGEVLNDMLRHPGPNREPVLTGQLFGGYGSVLPKSPKAQKPVPVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D714</accession>
    <name>Q1D714_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3362"/>
    <dbReference type="EnsemblBacteria" id="ABF88510">
        <property type="protein sequence ID" value="ABF88510"/>
        <property type="gene ID" value="MXAN_3362"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3362"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1625309_0_0_7"/>
    <dbReference type="OMA" id="REFHDFG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="18070" checksum="4DA10B4908CD38A0" modified="2006-07-11" version="1">MRRLHDSREKVAMWGVTKRANPVHCAPGGRTPRVLRGRTEAMTLQPRLRANLESTAMSGLQIHREESAGSVTLRLEGTLDGKTAEEVRTSLSALSGCEVVLDFAHLREFKDSAVGVLTRGLVERPVQLRGLATHHERMFRYFGVGTGTSPRPAYYTPEDVFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D717</accession>
    <name>Q1D717_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase-like superfamily domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF87606">
        <property type="protein sequence ID" value="ABF87606"/>
        <property type="gene ID" value="MXAN_3359"/>
    </dbReference>
    <dbReference type="GeneID" id="41360708"/>
    <dbReference type="KEGG" id="mxa:MXAN_3359"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012397_2_0_7"/>
    <dbReference type="OMA" id="QFDAHAW"/>
    <dbReference type="OrthoDB" id="175884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="438"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="698" mass="74852" checksum="B444A7906D6F4E54" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D736</accession>
    <name>Q1D736_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
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        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3338"/>
    <dbReference type="EnsemblBacteria" id="ABF88183">
        <property type="protein sequence ID" value="ABF88183"/>
        <property type="gene ID" value="MXAN_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3338"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="ITIFDFG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
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            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="536" mass="56548" checksum="2917ADB495B00FB1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D746</accession>
    <name>Q1D746_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3328"/>
    <dbReference type="EnsemblBacteria" id="ABF91888">
        <property type="protein sequence ID" value="ABF91888"/>
        <property type="gene ID" value="MXAN_3328"/>
    </dbReference>
    <dbReference type="GeneID" id="41360681"/>
    <dbReference type="KEGG" id="mxa:MXAN_3328"/>
    <dbReference type="HOGENOM" id="CLU_1260318_0_0_7"/>
    <dbReference type="OMA" id="RFFKYKA"/>
    <dbReference type="OrthoDB" id="1111586at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24508" checksum="877D648A1CC56520" modified="2006-07-11" version="1">MSDGRKPSQPGTQPPRAASPSGSQPRTPTSPGMPRAPSQSNLRVMSAARAEPLVKEKPDGPLGKRLAGDASNHLLNGVSILKELVADFRRSDRFFKYKASIIAGWLVMTVTSLAIACPGSTVRKGDMDARLVLSDRLDRPSVTIWNESKEPWYDVTLTVNGQYQAAVLTVAPGEFITITPKQLMGSSGAAPADLRFQSIQMRSRDDSADLTADLNAAWERIHKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7G7</accession>
    <name>Q1D7G7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D7G7"/>
    <dbReference type="STRING" id="246197.MXAN_3205"/>
    <dbReference type="EnsemblBacteria" id="ABF92126">
        <property type="protein sequence ID" value="ABF92126"/>
        <property type="gene ID" value="MXAN_3205"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3205"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_7"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="14064" checksum="2E4D36194C1F2C1F" modified="2006-07-11" version="1">MRRMARKAIHSDQAPKAIGPYSQAVQVDAGKMTFLSGQIPLDPATMEMVQGDVVAQAERVMENLKAVLAASGLDFSHVVRCTIFLTDLGDFARVNEVYGRYFTGAPPARATVQVSALPRGSKVEIDAIAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W4</accession>
    <name>Q1D7W4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3051</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553106.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3051"/>
    <dbReference type="EnsemblBacteria" id="ABF91770">
        <property type="protein sequence ID" value="ABF91770"/>
        <property type="gene ID" value="MXAN_3051"/>
    </dbReference>
    <dbReference type="GeneID" id="41360413"/>
    <dbReference type="KEGG" id="mxa:MXAN_3051"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_0_0_7"/>
    <dbReference type="OMA" id="DRMLYIH"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022569">
        <property type="entry name" value="Fd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11953">
        <property type="entry name" value="DUF3470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="12304" checksum="A34EB3F523D8EE05" modified="2006-07-11" version="1">MAYVVADPCIKCKYTDCVEVCPVNCFYEGANFLVIHPDECIDCGACEPVCPTKAIFPETELPEQWKEYKALNADLSTKWPNIAEKKSALPEAEEFKSKDGKRSLLDPAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7X7</accession>
    <name>Q1D7X7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553093.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3037"/>
    <dbReference type="EnsemblBacteria" id="ABF88580">
        <property type="protein sequence ID" value="ABF88580"/>
        <property type="gene ID" value="MXAN_3037"/>
    </dbReference>
    <dbReference type="GeneID" id="41360399"/>
    <dbReference type="KEGG" id="mxa:MXAN_3037"/>
    <dbReference type="HOGENOM" id="CLU_112879_0_0_7"/>
    <dbReference type="OMA" id="FRDFMPH"/>
    <dbReference type="OrthoDB" id="1255131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23046" checksum="5DEF73B38994E39B" modified="2006-07-11" version="1">MPPPSAGVAMIAFEVARGTPEPLTELARRLSRAEEKDRARGMFFLGALDVVRMEVGEAAAARCLAASRERAFVPFFLYPITSFLRLSFSAAGLLAPRLGGFEAAMRTIGARSAQDFLSTVVGRSFLALSGGCPRRLVSNLPSGYSTAVSYGERDVEWVGERQGRLNMFRDFMPHSYHEGVLRAALAAIGARDTHIRGRATGLLDGEYEVSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Z1</accession>
    <name>Q1D7Z1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome_C7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3023"/>
    <dbReference type="EnsemblBacteria" id="ABF89307">
        <property type="protein sequence ID" value="ABF89307"/>
        <property type="gene ID" value="MXAN_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3023"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116684_0_0_7"/>
    <dbReference type="OMA" id="GCHPEAY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="21667" checksum="61E6759D760D0F77" modified="2006-07-11" version="1">MRIRLLPAGTGGQGSSNPLCPTEVSAGHSTTRRLAPSGGLCYSGFMRVPGIRILSLLVLAAAGAAGGADFVGPDSCKGCHPEAYDAWMQSKHARAESSLTDQQKKDGRCLSCHSPEQVTQATVNVTCETCHGGGQYYSPEYVMKDSELARLVGLVDPSEKQCRSCHDASSPSLRPFDFKESLKAIDHWSAERARRAADPSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D817</accession>
    <name>Q1D817_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HAMP domain/GAF domain/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553053.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2997"/>
    <dbReference type="EnsemblBacteria" id="ABF92564">
        <property type="protein sequence ID" value="ABF92564"/>
        <property type="gene ID" value="MXAN_2997"/>
    </dbReference>
    <dbReference type="GeneID" id="41360359"/>
    <dbReference type="KEGG" id="mxa:MXAN_2997"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_7"/>
    <dbReference type="OMA" id="PLGGPEC"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="475"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="645" mass="69988" checksum="A311EAED15476F4D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8A6</accession>
    <name>Q1D8A6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin acylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2906"/>
    <dbReference type="MEROPS" id="S45.004"/>
    <dbReference type="EnsemblBacteria" id="ABF89234">
        <property type="protein sequence ID" value="ABF89234"/>
        <property type="gene ID" value="MXAN_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2906"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017615_0_0_7"/>
    <dbReference type="OMA" id="QGIPWVN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188359" evidence="5">
        <location>
            <begin position="28"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="823" mass="88884" checksum="083305B9B6720632" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8C9</accession>
    <name>Q1D8C9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552944.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2883"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92214">
        <property type="protein sequence ID" value="ABF92214"/>
        <property type="gene ID" value="MXAN_2883"/>
    </dbReference>
    <dbReference type="GeneID" id="41360252"/>
    <dbReference type="KEGG" id="mxa:MXAN_2883"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661934_0_0_7"/>
    <dbReference type="OMA" id="NPGTIVW"/>
    <dbReference type="OrthoDB" id="1584052at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188360" evidence="2">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="431" mass="46990" checksum="E0F56E0FF6CFB311" modified="2006-07-11" version="1">MKKTLLLVGTLLGMSSTGCGAPEDDVSSEAGASPIEFDALDNSAVSAAALTTPGCTALTARSVISNGDDGNVAANTMDDNLGTRWSRSGRGSWVDYDLGSIQQVAGVSVAWHQGNTRTNEFLVSVSPDGYTYTQVYSGKSSGTTAAAETYSFKAVNTRRVRITFQSNNVNEWASIAEARACSSTTSTPTDPTPNPDPTPEQPPPGTGASVVWVGDFETNSRSQWSHTQMVSADRLALVSSPARQGRYALKATVRKGDDPINSSGNRNELVRMTREATGSEYYYRFSTMFDSSFPSAKTWQLFTQWHHEGNSGSPPVEFYVYGEEIRLNIGGNPGTIVWRTPLVRGRWLDFIFHVKWSPDSKVGFVELYLNGKVVLPKRYIATQYKGQLNYLKVGLYRNDTISPVGIVYHDGWTMARKLEDVISPTAVLKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D4</accession>
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            <fullName evidence="3">Putative bacterioferritin</fullName>
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        <name evidence="3" type="ORF">MXAN_2878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2878"/>
    <dbReference type="EnsemblBacteria" id="ABF90475">
        <property type="protein sequence ID" value="ABF90475"/>
        <property type="gene ID" value="MXAN_2878"/>
    </dbReference>
    <dbReference type="GeneID" id="41360247"/>
    <dbReference type="KEGG" id="mxa:MXAN_2878"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_4_1_7"/>
    <dbReference type="OMA" id="CTLRYKR"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47240"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="21348" checksum="34123D167654FD98" modified="2006-07-11" version="1">MAEVQQPFLTDITEIRRRAREHLEEGAITEDYEGDVNATIKLLNDALATEIVCVLRYTYHYVAAVGIQSESVKDEFGTHAREEQQHALRIAERINQLGGKADFNPEGLLSRSASQYAEGQNLVDMIKENLIAERIAIQTYQEMVRYFANHDPTTRRMMEDILAKEEEHANDMHDLLVAHQGKPPLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8L8</accession>
    <name>Q1D8L8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske 2Fe-2S domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552855.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2788"/>
    <dbReference type="EnsemblBacteria" id="ABF88563">
        <property type="protein sequence ID" value="ABF88563"/>
        <property type="gene ID" value="MXAN_2788"/>
    </dbReference>
    <dbReference type="GeneID" id="41360164"/>
    <dbReference type="KEGG" id="mxa:MXAN_2788"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_4_3_7"/>
    <dbReference type="OMA" id="RCPHAGL"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13403" checksum="A6D444A6FDDE0927" modified="2006-07-11" version="1">MSTGGETAGRKRVWSTPANVKLLPVSALEDPGARNLVLQIGDAFFHGFLVRKGDAVHGYVDRCPHAGLPLARELDRYLTPDKGLIVCAWHGALFQVEDGLCVGGPCSGGRLTPWPVTVRDGIVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D915</accession>
    <name>Q1D915_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2639"/>
    <dbReference type="EnsemblBacteria" id="ABF88190">
        <property type="protein sequence ID" value="ABF88190"/>
        <property type="gene ID" value="MXAN_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2639"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085620_0_0_7"/>
    <dbReference type="OMA" id="FRIHYGI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="27107" checksum="CE6ED4D4BF9D488B" modified="2006-07-11" version="1">MAQESVNPAFGPGEQSSYRVRYLGITAGTAQVTVGAHMKQWGQDVWPIVAVARSNDMLGVWPIKDKFVSYWQPESQRVVGSDLHADENGSRRRQRIKMEPDGKTAFVVKQKEGESPRESTREVMEGTLDVTGATFALRNRELVVGQEYAYPVFTGSKQFTLRAKVEGREVLGTAMGDKEVFKLSVKTEFGGNLASKRDMFVYFTTDSSHVPVRVEAEFALGTIVAEITDYKPGRSMTVARAENGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D963</accession>
    <name>Q1D963_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <ligand>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="213" mass="25181" checksum="6C9876F7CD9EDA06" modified="2006-07-11" version="1">MRVKVPKARRFVALAGNIGAGKTTAAKMISQAFGYELFDEPVIDNRFLRDYYADMTRWSFTLQLEFLIRRVEHHELIHSYRRSCVQDRTLYEDPEIFAKYLHGLGHLTNAELDLYYEYFQRLSRHIIRPDKVICFEVGSVEVLLQRIRTRGREEEKGIRHQFLRGLNGYYASFPLVIQEKYGVDCLTMDVSKQDIRRGRGREEFLDRVSTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
    <sequence length="30" mass="3385" checksum="88E08411D3FBD642" modified="2006-07-11" version="1">MGASRGDLPRGKKGLFKREGAHRIKSRVFE</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
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    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="274" mass="30461" checksum="1F9B72EB72570917" modified="2006-07-11" version="1">MPGAAEPGLGDYPRVGSLQRLVTRTRAGWLVDLLSEERLTTHFQPIVHAQDTRCIFAHEALMRGLEPDGTLVLPGRMMQTAREADLLFQLDLAARTTAIRQAVKHGLDTHLFINFTPTAIYDATVCLRSTVEAIHAAGIAPERVVFEIIETDQTADAEHLRGIVDFYRKSGFRVALDDLGAGFSSLNLIHRLRPDIIKLDMELVRDVHLDPYKGSIVEKLLEIARTLGIRTVAEGIETHEELRWVRSHGVDFVQGYLIARPQSPPVGATPSFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V0</accession>
    <name>Q1D9V0_MYXXD</name>
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        <submittedName>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="family name" value="the oligopeptide transporter (opt) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89237">
        <property type="protein sequence ID" value="ABF89237"/>
        <property type="gene ID" value="MXAN_2353"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="CDMQQDR"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="586" mass="61742" checksum="290446FBE9235227" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA19</accession>
    <name>Q1DA19_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(20/20a) synthase</fullName>
            <ecNumber evidence="6">1.3.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">U20-specific dihydrouridine synthase</fullName>
            <shortName evidence="6">U20-specific Dus</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-dihydrouridine synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dusA</name>
        <name evidence="10" type="ORF">MXAN_2283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53340"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53336"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Dus family. DusA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.91" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552359.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2283"/>
    <dbReference type="EnsemblBacteria" id="ABF90496">
        <property type="protein sequence ID" value="ABF90496"/>
        <property type="gene ID" value="MXAN_2283"/>
    </dbReference>
    <dbReference type="GeneID" id="41359670"/>
    <dbReference type="KEGG" id="mxa:MXAN_2283"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_2_1_7"/>
    <dbReference type="OMA" id="LIYPYVD"/>
    <dbReference type="OrthoDB" id="1320183at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02041">
        <property type="entry name" value="DusA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="PTHR42907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00742">
        <property type="entry name" value="yjbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Dus" evidence="9">
        <location>
            <begin position="11"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="site" description="Interacts with tRNA" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with tRNA; defines subfamily-specific binding signature" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="36808" checksum="168FE1FFB9AD14BE" modified="2006-07-11" version="1">MMPTHPMPLSVAPMMDWTDRNCRYFHRQLSRHTLLYTEMVTTGAILHGDRERLLGYDAAEHPVALQLGGSEPAALAESARIGEQWGYDEINLNVGCPSDRVQSGRFGACLMAEPDLVARLVGAMREAVSIPVTVKSRIAIDELEEWPTLEGFIRKVSAAGCTRFIVHARKAWLQGLSPKENRDVPPLRYDLVHRLKVEFPHLDISINGGIKTLDAAAEQLRHVDGVMMGRAPYENPYLLAEADRRFFGATTPVPQRHEVVEAMLPYIEKAMLRGAPLGAITRHMLGLFQGLPGARAWRRHLSENAHKQGAGPEVVVAALAKVRREPEAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAB5</accession>
    <name>Q1DAB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552263.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2185"/>
    <dbReference type="EnsemblBacteria" id="ABF90787">
        <property type="protein sequence ID" value="ABF90787"/>
        <property type="gene ID" value="MXAN_2185"/>
    </dbReference>
    <dbReference type="GeneID" id="41359577"/>
    <dbReference type="KEGG" id="mxa:MXAN_2185"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_7"/>
    <dbReference type="OMA" id="EQWINLM"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17426" checksum="BE0E504DE9C34A52" modified="2006-07-11" version="1">MKPRMNAFAVAPDAMKLTLDYGQKLLELGLEKSLQELVKIRASQLNGCAFCIHMHSRDARAHGETEERIYLLDGWRESPLYTERERAALAWTEALTHVSQTHASDEDYAALAPHFSEQEIVHLTLLIGMINTWNRISVGFRSIHPVTTPRTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAL3</accession>
    <name>Q1DAL3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2081"/>
    <dbReference type="EnsemblBacteria" id="ABF92896">
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        <property type="gene ID" value="MXAN_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2081"/>
    <dbReference type="HOGENOM" id="CLU_1388929_0_0_7"/>
    <dbReference type="OMA" id="ERWPEDR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188582" evidence="1">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="20994" checksum="F4A6C5831152DCEC" modified="2006-07-11" version="1">MMRRWLPGLLLSLVTVLTACGEAGAPVRATMSARQALTNPPEFLEFEAPSTRLELFREVARQSVIEAGQAAQALVLFPVSHQGELLAAPGFDPKMDLFQAPDAGAPLELVFESGGERWPDDRREGLQGLSEREAAELVARTLLAHWGIAPNSAVQVDRASGAPYAVAYVDGILRINPAFLYLAAAYGPSSLPASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAQ0</accession>
    <name>Q1DAQ0_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Protein phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pph1</name>
        <name evidence="2" type="ORF">MXAN_2044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552128.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2044"/>
    <dbReference type="EnsemblBacteria" id="ABF93082">
        <property type="protein sequence ID" value="ABF93082"/>
        <property type="gene ID" value="MXAN_2044"/>
    </dbReference>
    <dbReference type="GeneID" id="41359453"/>
    <dbReference type="KEGG" id="mxa:MXAN_2044"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_3_2_7"/>
    <dbReference type="OMA" id="CVLARYH"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="28267" checksum="B11E3FF9CDA0EA71" modified="2006-07-11" version="1">MRIEVAGSTHVGMKRNHNEDNFLMLPEEFLFCVADGMGGHSSGEIASRIAVDELGEFYKLTSKDQDCTWPFKMDKTRNYDENRLATGVKLANARIFEKACSESKYKGMGTTIVTVHFSQSAVYVGHVGDSRVYYFRGGALKQVTEDHSLLNDYLKAKKLSPEEIENFPHKNVIVRALGMKENVQVDVSRVEPQEDDVFLLCSDGLSGMVTDAQMQEILQRTPELEKACSQLIDMANAAGGNDNVTCVLARYHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR8</accession>
    <name>Q1DAR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepP</name>
        <name evidence="5" type="ORF">MXAN_2026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552110.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2026"/>
    <dbReference type="MEROPS" id="M24.033"/>
    <dbReference type="EnsemblBacteria" id="ABF92854">
        <property type="protein sequence ID" value="ABF92854"/>
        <property type="gene ID" value="MXAN_2026"/>
    </dbReference>
    <dbReference type="GeneID" id="41359436"/>
    <dbReference type="KEGG" id="mxa:MXAN_2026"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_7"/>
    <dbReference type="OMA" id="GWADTEL"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="4">
        <location>
            <begin position="67"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="516" mass="57017" checksum="8969B9D7902877C9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBA0</accession>
    <name>Q1DBA0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551929.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87296">
        <property type="protein sequence ID" value="ABF87296"/>
        <property type="gene ID" value="MXAN_1827"/>
    </dbReference>
    <dbReference type="GeneID" id="41359244"/>
    <dbReference type="KEGG" id="mxa:MXAN_1827"/>
    <dbReference type="HOGENOM" id="CLU_1667507_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17870" checksum="61646CB1F81C0FE7" modified="2006-07-11" version="1">MRAAGPLARRAPRSLAHDMKTSHIISVPQKLGLGVPNRRAALLSDVESLLPHPIRPGDYRVTIERLESPSDVPVYVDVEGALFRFANQRAWARLLLHWVRTRNQGVPTGMLRRLAERIPIIHTCLPRLVDWGAEDAQAALNELRHTAIRERLHRPKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC59</accession>
    <name>Q1DC59_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551623.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1512"/>
    <dbReference type="EnsemblBacteria" id="ABF92694">
        <property type="protein sequence ID" value="ABF92694"/>
        <property type="gene ID" value="MXAN_1512"/>
    </dbReference>
    <dbReference type="GeneID" id="41358958"/>
    <dbReference type="KEGG" id="mxa:MXAN_1512"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044823_0_0_7"/>
    <dbReference type="OMA" id="LWMRVEG"/>
    <dbReference type="OrthoDB" id="500099at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188608" evidence="2">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="42130" checksum="5B9355F6071E4229" modified="2006-07-11" version="1">MDFRKKLAALLLALASTGAGAQPSEGAQKLPVGWYVTESAPKRYEAGVDSSATCEGNRSAYLRSLSPDENGYGTFMQAFGAHDFRGKRLRFSGALRIKDVEGWAGLWMRVEGPDPKQPLAFDNMQSRALVGTAGCKRYDVVLDVPKEATTIMAGLIMSGTGQAWLDGVRFEVVDTSVPVTDLLASRPVVAAAGPSGLEDEPAPVAKNDQLPLGRVGDVWFNHGRIAADKPYTRRKDGVWVSILGEEVYEHGIAVTGTLGQRALELKLKAGGRRTLIEGTWGGEPVNIQLTPEKLTMRWGRTMREMARHLDPQVGTTCNRYQRTEGPRVLDQLDVCGAALGTRPPNAQLIIALLVNGFSPTLPAGSIPIPRPPVRSRQALDTERTALPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL3</accession>
    <name>Q1DCL3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1353"/>
    <dbReference type="EnsemblBacteria" id="ABF88205">
        <property type="protein sequence ID" value="ABF88205"/>
        <property type="gene ID" value="MXAN_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1353"/>
    <dbReference type="HOGENOM" id="CLU_616527_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="45667" checksum="DD643C153F3D0021" modified="2006-07-11" version="1">MPRALQPSSRVTPVCACRSGADGRPEDASRGDVSRMSLPASGRRPGLASERAGLPRALYARRTKLRLPTMRSAPSLPLLVFALVGDVQARPAEGAPLAAVPSQPRASGAEASKARVPSAGSSKASAPSQPGAPASGGGAPARVPSGTAPATASAPAEPPGAPPRNPAPDTSWAQPGQVPAPARNEAPDDAAWESFPGATAVPEEEDAATLPQLPEVPPLVPVDEAAIPAPRPPPAPVRPPPVPNRVSLLGAQTVGAGGMAVGLALGFPIVSARVAVGVHRRVDVLAGVDSAYGLMSELRVGARWMVLDGGPRWSVGVAVEGSHAFFLRPASVEDRGARYYSGRRNWNVLPGIVGNLQLPGARSPRLFLDVRYLMALDTEPIQGVPLGGLPPDVELSGAFPVRLGAEIPVSEKTSYALTIGGDIRTRPDETDFMPVITFGVVTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM6</accession>
    <name>Q1DCM6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551457.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1340"/>
    <dbReference type="EnsemblBacteria" id="ABF90885">
        <property type="protein sequence ID" value="ABF90885"/>
        <property type="gene ID" value="MXAN_1340"/>
    </dbReference>
    <dbReference type="GeneID" id="41358786"/>
    <dbReference type="KEGG" id="mxa:MXAN_1340"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_2_7"/>
    <dbReference type="OMA" id="GNTKIWG"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="424"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="550" mass="59536" checksum="D40CBA0EAFB8A76E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCN5</accession>
    <name>Q1DCN5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1331"/>
    <dbReference type="EnsemblBacteria" id="ABF92101">
        <property type="protein sequence ID" value="ABF92101"/>
        <property type="gene ID" value="MXAN_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1331"/>
    <dbReference type="HOGENOM" id="CLU_1905490_0_0_7"/>
    <dbReference type="OMA" id="IQGQTNK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="17619" checksum="7A8AEC9D8FE8711C" modified="2006-07-11" version="1">MPSTPGRARRHMRAGVCVDSSVHASLNLLMMRRFLLCMAVAQLLGVGTLVAPAEAWAQSRGRTSRQAKSKAAKKAASKTPPKIETKGSSVVDPVTGDAATASSNALPQRGPARIDFDDRLIQGQTNKSGAVYLYDRKELKTRSMIRERESFRSETLSTVYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD48</accession>
    <name>Q1DD48_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1165"/>
    <dbReference type="EnsemblBacteria" id="ABF87896">
        <property type="protein sequence ID" value="ABF87896"/>
        <property type="gene ID" value="MXAN_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1165"/>
    <dbReference type="eggNOG" id="ENOG5030T7N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198741_0_0_7"/>
    <dbReference type="OMA" id="EEHNTQL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="25975" checksum="B1407C1C7B64869C" modified="2006-07-11" version="1">MPAALSEGEQVSCGDVRGEKLRSWSSDNGGRLPRRAVAALTMTEHLSKLRASSGCRVSAQHLRRACRAVMVWERWSMRFLCFATALAVLGTGCATGIPLERLEAQVLEADRWRREYEAERERTEAFALRMAQLESALERVLLERAEAEQARAALLEELVRTEADRHALEEHNTQLLALEREVNELKELKEMHEELSDVWYESALERARRRLNNPPQPAAPPAAGNVAPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDF5</accession>
    <name>Q1DDF5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551178.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1057"/>
    <dbReference type="EnsemblBacteria" id="ABF86145">
        <property type="protein sequence ID" value="ABF86145"/>
        <property type="gene ID" value="MXAN_1057"/>
    </dbReference>
    <dbReference type="GeneID" id="41358510"/>
    <dbReference type="KEGG" id="mxa:MXAN_1057"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_0_7"/>
    <dbReference type="OMA" id="FIQHRGR"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="317" mass="34442" checksum="4F161CE348321D89" modified="2006-07-11" version="1">MERPPLAKRLKRFLRYVLIRGVLLLLQPLPLGVARSLGARLGALAYTLAGGERRKALKSLSVAFPEKSDADRQALARDAFRHLAAAALEVACTGALDEALERLVAWPDADRQVLETALARGRGVVFVSGHVGNWELLARRVARAGYPSQSIAKETTDPRLTELVGQFRARGGVRSIWRGQEGAARAMLRALRNGEILGILIDQDTKVQSLFVPFFGQLAATPRAAADLAIRTGAAVVTGFCHREGAGYRLSMEEVPVPQDTDREAAALALTAALSSRIEAAIRRTPEQWVWMHQRWKTRPPVSEDVPLPEAAPASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDI6</accession>
    <name>Q1DDI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551147.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1026"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91375">
        <property type="protein sequence ID" value="ABF91375"/>
        <property type="gene ID" value="MXAN_1026"/>
    </dbReference>
    <dbReference type="GeneID" id="41358480"/>
    <dbReference type="KEGG" id="mxa:MXAN_1026"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_7"/>
    <dbReference type="OMA" id="AIVFPSH"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="44568" checksum="8A9E3E2150253429" modified="2006-07-11" version="1">MNAPSAGAGLRVLHLGKFYPPASGGMEAHVQTLARAQAALGAQVEVLCANHAADGAGTSHEFQGRSPTCETWDGPVRVTRLGRLASVARMDAMPDLPRMLGRALSRGVDIVHLHTPNPTWVLALDVVRRLPPVFITHHSDVIRQRVAGALFKPFEALLYARARRVLATSEAYVSGSPLLRAFRGKVRALPLGLDLAPYLHPCAAAREAEAHWRAQAAGAPLWLMVGRLVYYKGLFTALQALRRVPGRLVVVGQGPLEAEARRRARALGVADRVTWAGYLPPDSLVGALHAATALWFCGNARSEAYGLSQVEAMASGLPVLNTAIPHSGVAWVSLHEQTGLTVPVGDAEALAAAARRLLEEPGLAQRLGREARERAVAEFRHDVMAWRSLSLYSEALGRPAPVMAPDVALLRLTGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS6</accession>
    <name>Q1DDS6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaminyl-peptide cyclotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551057.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0936"/>
    <dbReference type="EnsemblBacteria" id="ABF92029">
        <property type="protein sequence ID" value="ABF92029"/>
        <property type="gene ID" value="MXAN_0936"/>
    </dbReference>
    <dbReference type="GeneID" id="41358395"/>
    <dbReference type="KEGG" id="mxa:MXAN_0936"/>
    <dbReference type="eggNOG" id="COG3823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060272_2_2_7"/>
    <dbReference type="OMA" id="FVTGKNW"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="BRENDA" id="2.3.2.5">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="28986" checksum="34CCAD6C730FEF64" modified="2006-07-11" version="1">MRIPSSLLSLLALGAACHCSPTNRPVPDAGGSVQEPVRRVAHIIREYPHATNAFTQGLVFHQGHLFESTGHQGTLRQLSLESAQPVWMERLGNIFAEGLASDGERLYQLTWTEGLLFTWSGMPPQRERTTRYSGEGWGLCYWNGKLVRSDGGTMLTFHEPDGFALVGAVQVKLRGQPVELINELECANGVIYANIWHSSDVLEIDPATGTVVGVIDASALTRAVAGQVTNPEAVLNGIAVEPGSGRIFMTGKLWPRLFEVRLDVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDV3</accession>
    <name>Q1DDV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551030.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0909"/>
    <dbReference type="EnsemblBacteria" id="ABF89537">
        <property type="protein sequence ID" value="ABF89537"/>
        <property type="gene ID" value="MXAN_0909"/>
    </dbReference>
    <dbReference type="GeneID" id="41358368"/>
    <dbReference type="KEGG" id="mxa:MXAN_0909"/>
    <dbReference type="HOGENOM" id="CLU_1625301_0_0_7"/>
    <dbReference type="OMA" id="ENVCCTA"/>
    <dbReference type="OrthoDB" id="1636743at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188429" evidence="1">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="170" mass="17540" checksum="B68F03B83C45DF3F" modified="2006-07-11" version="1">MKKSLSFVSKSVAALAMLSTLPAFAGTATYSGALCTSVSGFHSPTVFRSGRLLNSNANTLEVVCPIQRNVAVPSLNESLSVSVTALDPHLTENVCCTATVAEKDGTSLASSSACSSWGADTANHNSFSINLPSVFANINGYVSLRCVLPGQYTSGSSTYASVLASFVVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE11</accession>
    <name>Q1DE11_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, molybdopterin-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0850"/>
    <dbReference type="EnsemblBacteria" id="ABF88373">
        <property type="protein sequence ID" value="ABF88373"/>
        <property type="gene ID" value="MXAN_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0850"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_7"/>
    <dbReference type="OMA" id="RIKYPMA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="3">
        <location>
            <begin position="533"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="669" mass="72508" checksum="C1E9402683746AFE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE66</accession>
    <name>Q1DE66_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87698">
        <property type="protein sequence ID" value="ABF87698"/>
        <property type="gene ID" value="MXAN_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0794"/>
    <dbReference type="eggNOG" id="ENOG502Z82H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048230_1_0_7"/>
    <dbReference type="OMA" id="FIDMVPM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011673">
        <property type="entry name" value="DUF1615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07759">
        <property type="entry name" value="DUF1615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="43052" checksum="14C3FDAE24D9F86D" modified="2006-07-11" version="1">MLVALGSMTACAPRGAGSAQPSIPPPPRLSASQVAKLMPPQLQDREGWARDVLAALEVEEIAPSPPAVCSVLAVIEQESGYKVDPAVAGLPKMVRTRLEEHANKLGPLGRKVLASVLEGRAKGSKKTFDERLRALRTERDLDRLFRDMLAYYENEFPSAFKVVDFASGVFASGNLHEFNPVTTAGSMQVSVRYAMQKAGEDADPAEVRESMYTRAGGVRYGTARLLGYEAAYPEPLFRFADYNAGVYASRNAALQSQVSRLTGHPLAPDGDLQLYDKQGQPRSEDSKSLLALLAFRQRFAPEELSERQVRRDVRKEKEPDFESTDTFRAVKRVYQRETGESPSYAQLPRVTLQSPKLKRELTTAWFARSVDQRFQKCMTRYRALTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEK3</accession>
    <name>Q1DEK3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550783.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0652"/>
    <dbReference type="EnsemblBacteria" id="ABF86329">
        <property type="protein sequence ID" value="ABF86329"/>
        <property type="gene ID" value="MXAN_0652"/>
    </dbReference>
    <dbReference type="GeneID" id="41358127"/>
    <dbReference type="KEGG" id="mxa:MXAN_0652"/>
    <dbReference type="eggNOG" id="COG1718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075702_0_0_7"/>
    <dbReference type="OMA" id="HGATMIW"/>
    <dbReference type="OrthoDB" id="1347131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="28610" checksum="B38D051E677DBBC8" modified="2006-07-11" version="1">MPRTVTATRYVTPLREGGSLPAIIEADDAGLYVVKFRGAGQGAKALVAELIAGELARELGLRVPELVLVELDPALGRNEPDSEIRELLKASAGLNLALDYLPASVTFDPVADPAPTAAEASGIVAFDAYITNVDRTPRNPNMLTWHRNLWLIDHGASLYFHHSWDDWEARSQGRFAPIKDHVLLPWATALTEAGKHLGARITREVVERIVGAIPEAWLTSTESPFPTAEAHRAAYTTWLLRRLEAVPAFIEEADRARAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP5</accession>
    <name>Q1DEP5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550741.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0610"/>
    <dbReference type="EnsemblBacteria" id="ABF87640">
        <property type="protein sequence ID" value="ABF87640"/>
        <property type="gene ID" value="MXAN_0610"/>
    </dbReference>
    <dbReference type="GeneID" id="41358088"/>
    <dbReference type="KEGG" id="mxa:MXAN_0610"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560091_0_0_7"/>
    <dbReference type="OMA" id="MAGGFHH"/>
    <dbReference type="OrthoDB" id="202593at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="55"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="586" mass="64292" checksum="5E466BF59BE03AEA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF33</accession>
    <name>Q1DF33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550603.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0470"/>
    <dbReference type="ESTHER" id="myxxd-q1df33">
        <property type="family name" value="Abhydr_predicted"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88220">
        <property type="protein sequence ID" value="ABF88220"/>
        <property type="gene ID" value="MXAN_0470"/>
    </dbReference>
    <dbReference type="GeneID" id="41357963"/>
    <dbReference type="KEGG" id="mxa:MXAN_0470"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020280_0_0_7"/>
    <dbReference type="OMA" id="RQFARWI"/>
    <dbReference type="OrthoDB" id="891360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="54"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="339" mass="37217" checksum="14554F8D2E65DBCD" modified="2006-07-11" version="1">MADLFSRTMVRGKEGLLTLTFRPDELYRVPTDDGASIALGRYHARGEKRFAQPVILCHGLGANRFHMDFDEQYSLARYLARSGFETWVLELRGRGLAGDCPDFNFDDQAEHDVRTAVRTVLSTGAKEVLWVGHSKGGLMLYAHLAKTPQAPVRAAVTLGSPFTFAVQPGLRTFIQKVEPVLKLRVIPTSRVTSIALFGAPPGPMSRYMMLAENMETEVVRRALANVPADIAGGVGRQFARWITTNRFTSYNGEFDYRESLSRVTIPFLLLAGSKDLLAPPMAVARAKEYLGGPVKVLVAGKAHGFGADYGHADLVLGRRAPDEIFPLVEAFLSAHATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF34</accession>
    <name>Q1DF34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative foldase protein PrsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550602.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0469"/>
    <dbReference type="EnsemblBacteria" id="ABF89263">
        <property type="protein sequence ID" value="ABF89263"/>
        <property type="gene ID" value="MXAN_0469"/>
    </dbReference>
    <dbReference type="GeneID" id="41357962"/>
    <dbReference type="KEGG" id="mxa:MXAN_0469"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_5_3_7"/>
    <dbReference type="OMA" id="QKAKNQY"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="196"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="39223" checksum="34FD9D4412ACB861" modified="2006-07-11" version="1">MTDGLPIWSPPPHEAPRMRFSPTRAFLVPLAIALAAGVGMPACTKPVMETPEALVVASVNGEVLSRADFEQELWRELALTDVSQRTLEDVEPFKRALLDTYIHRMLLLQEARKHNVTVTPEEVDRGVLRLSGDYPAGNFNEVLAQGQLSMAELRSREASRLTIEKLFASHVYSRVAVTEEELRAWYGAHEKDFHEPEQVHAAQIVVKGLDEARRLQTQLKSGKKFADLARRYSLSADAKVGGDLGFFPRGQMPPAFDEVVFKLGVGQVSDVVSTEYGFHLFRVLERKPARKREFVEVRSLVEGKLLEQKRSQAQETFEQELRQKAQVQVNEATLQAIRGRPTPQQATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF79</accession>
    <name>Q1DF79_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain/band 7 family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550557.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0423"/>
    <dbReference type="EnsemblBacteria" id="ABF90706">
        <property type="protein sequence ID" value="ABF90706"/>
        <property type="gene ID" value="MXAN_0423"/>
    </dbReference>
    <dbReference type="GeneID" id="41357917"/>
    <dbReference type="KEGG" id="mxa:MXAN_0423"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027197_1_1_7"/>
    <dbReference type="OMA" id="GQEVMTK"/>
    <dbReference type="OrthoDB" id="809470at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="141"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="41836" checksum="C1B5164A3A78732C" modified="2006-07-11" version="1">MSIMRVDIGQNERAFVLVDEKPERYLVPGRYWLLHPFRKVRLVRVSTEQPLVQLDPAFLPLVPETDLQVVELSADERAILFHKGRPVRWLGRGLHQVWTVERLPSRQLTPGAPTVRVERVDTSGVTTAPLRDDVRALVPTSDYTEATATEGTVVLRYVDGVLDAELPPGRHAAWTVARKVQLAVIDLRERLLHVTGQEVMTKDRVTLRLNLSAAFRVSDARRLAVVSRAPDDVLYLAMQLAAREAVSERTLDELLASREAVAESLFTQVKDRAHTVGLDLLRFGIKDVVLPGEMKELLNRVIQAQKEAEANVILRREETAATRSMAQTAKVLAENPLLVRLKELEAYKDLASKVGQVHLVLGEGAVPTLQLKSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF98</accession>
    <name>ATPF_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit b</fullName>
            <shortName evidence="1">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpF</name>
        <name type="ordered locus">MXAN_0404</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF89279" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89279.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020478431.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DF98"/>
    <dbReference type="SMR" id="Q1DF98"/>
    <dbReference type="STRING" id="246197.MXAN_0404"/>
    <dbReference type="EnsemblBacteria" id="ABF89279">
        <property type="protein sequence ID" value="ABF89279"/>
        <property type="gene ID" value="MXAN_0404"/>
    </dbReference>
    <dbReference type="GeneID" id="41357898"/>
    <dbReference type="KEGG" id="mxa:MXAN_0404"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_4_1_7"/>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000368617" description="ATP synthase subunit b">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="184" mass="20615" checksum="ADE48474C80F895F" modified="2009-04-14" version="2">MFLPSVLAASNLVKVQPGLIFWTLVTFVIAAVVLKWKAWGPILSLVEEREKQIASSIESAKRERAEAEKLLADQKTAIAEARREAAEMMRRNTQEMEKFREELMAKSRKEAEELKLSARREIDEQKAKAIAEVRSMAVDLAMEVAGKLISERMDDSKQRALAEQFVQGLPLNSTSATGAVRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFA9</accession>
    <name>Q1DFA9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0393"/>
    <dbReference type="EnsemblBacteria" id="ABF90416">
        <property type="protein sequence ID" value="ABF90416"/>
        <property type="gene ID" value="MXAN_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0393"/>
    <dbReference type="HOGENOM" id="CLU_2410174_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="92" mass="10203" checksum="702E6DB05F37E330" modified="2006-07-11" version="1">MALAIFREERGELTRHFLQRLRMGGQGRARRRSGVSGLRRRGIEDRGGVPFWSTPEACAHHGCAQRPGEEDPAEPSTRIPHGVRASTSSGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFD4</accession>
    <name>Q1DFD4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550503.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0365"/>
    <dbReference type="EnsemblBacteria" id="ABF93016">
        <property type="protein sequence ID" value="ABF93016"/>
        <property type="gene ID" value="MXAN_0365"/>
    </dbReference>
    <dbReference type="GeneID" id="41357864"/>
    <dbReference type="KEGG" id="mxa:MXAN_0365"/>
    <dbReference type="eggNOG" id="COG1656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074576_0_0_7"/>
    <dbReference type="OMA" id="VPHTEVD"/>
    <dbReference type="OrthoDB" id="1234999at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="100"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="28535" checksum="EB1F38BC8DC64607" modified="2006-07-11" version="1">MDMGQPKAQVTMRFHGALNDFLSPAHRHQTFSHALRGRPSVKDLIESLGPPHPEMDVVRVDGEAVGFTHRVQPGACVEVYPTSMVEEPGVRVGPPLQDTPRFVLDVGLGRLVGFLRMLGFDALWRNDFADDTLARLSHDEDRILLSRDIGVLKRGEVLRGYFPRSTDPAEQLVEVVRRYGLTSRMHPFSRCVACNAALTSAEPSEVAGRIPERVAERHSRFQQCPDCQRVYWAGTHHQRMQALVVRLRELEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG00</accession>
    <name>Q1DG00_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550287.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0140"/>
    <dbReference type="EnsemblBacteria" id="ABF87722">
        <property type="protein sequence ID" value="ABF87722"/>
        <property type="gene ID" value="MXAN_0140"/>
    </dbReference>
    <dbReference type="GeneID" id="41357643"/>
    <dbReference type="KEGG" id="mxa:MXAN_0140"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028398_4_0_7"/>
    <dbReference type="OMA" id="EAWKATH"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03487">
        <property type="entry name" value="RT_Bac_retron_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="52959" checksum="F340755370736C39" modified="2006-07-11" version="1">MTARLDPFVPAASPQAVPTPELTAPSSDAAAKREARRLAHEALLVRAKAIDEAGGADDWVQAQLVSKGLAVEDLDFSSASEKDKKAWKEKKKAEATERRALKRQAHEAWKATHVGHLGAGVHWAEDRLADAFDVPHREERARANGLTELDSAEALAKALGLSVSKLRWFAFHREVDTATHYVSWTIPKRDGSKRTITSPKPELKAAQRWVLSNVVERLPVHGAAHGFVAGRSILTNALAHQGADVVVKVDLKDFFPSVTWRRVKGLLRKGGLPEGTSTLLSLLSTEAPREAVQFRGKLLHVAKGPRALPQGAPTSPGITNALCLKLDKRLSALAKRLGFTYTRYADDLTFSWTKAKQPKPRRTQRPPVAVLLSRVQEVVEAEGFRVHPDKTRVARKGTRQRVTGLVVNAAGKDAPAARVPRDVVRQLRAAIHNRKKGKPGREGESLEQLKGMAAFIHMTDPAKGRAFLAQLTELESTASAAPQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG29</accession>
    <name>Q1DG29_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550258.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0111"/>
    <dbReference type="EnsemblBacteria" id="ABF88401">
        <property type="protein sequence ID" value="ABF88401"/>
        <property type="gene ID" value="MXAN_0111"/>
    </dbReference>
    <dbReference type="GeneID" id="41357616"/>
    <dbReference type="KEGG" id="mxa:MXAN_0111"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623634_0_0_7"/>
    <dbReference type="OMA" id="RVYVPHW"/>
    <dbReference type="OrthoDB" id="842574at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="443" mass="47369" checksum="8EBED3CB6AAD14D5" modified="2006-07-11" version="1">MARARPTSPRCPRCNAPFALTQGQELYTCGYCNASIDTRGEKAPLPSYEAPPVPESEERGGIPVGVIQLAAIGGVVLALIALVVGFITWTTASESTGGPIPGGPGPAPIVVARPPGVEKASTFQWDTTSVPLVVDLNGDGTDDFVGRIRRLMPNTGGTDIRSMAAAFDGKSLGLLWETGLEGSISELSGTVHFVHQGGRVVMSSPDAVSILDPQTGKQLGRVALSDKPRNLCIPRGDTESVWVDVSDGQNLLLNTKTAAARPAIEPPPSCAPFKWGPRMCPPQLVRRSPIPCERPRDLPDVPGFSAQHVYKLNDLNVVLGERSPGSRVPMAAVFQQGQKVPLWHGNVADMDPKMVKERVVEVLAFSEDALVMVYELKEGGAQLIRRDMRTGSVSWDVPIPNSKSGSGASDIKLHGGRVYVPHWVWLDVFDAKTGNLIGTLGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA2</accession>
    <name>Q1DGA2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0038"/>
    <dbReference type="EnsemblBacteria" id="ABF87699">
        <property type="protein sequence ID" value="ABF87699"/>
        <property type="gene ID" value="MXAN_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0038"/>
    <dbReference type="HOGENOM" id="CLU_1617238_0_0_7"/>
    <dbReference type="OMA" id="ASDACFH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17587" checksum="9F5E5358DF0E30BC" modified="2006-07-11" version="1">MRASWPARLLCARRGARGPRPLSHPVEPGDASDACFHRLPVCLRHGGMLEDDGIIKLMRGVLATYSDKSRFGAAGLMLLLGLGVLLGAGSLALSAEPLIDDEWLAWPVGLLAPFVVGAVVAGFQKVKLWDWKFRFDLERFGAAFCVTTGFVLARFVGVPLLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH0</accession>
    <name>Q1CVH0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GspE N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557402.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7500"/>
    <dbReference type="EnsemblBacteria" id="ABF87845">
        <property type="protein sequence ID" value="ABF87845"/>
        <property type="gene ID" value="MXAN_7500"/>
    </dbReference>
    <dbReference type="GeneID" id="41364634"/>
    <dbReference type="KEGG" id="mxa:MXAN_7500"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049725_0_0_7"/>
    <dbReference type="OMA" id="QVLVYGW"/>
    <dbReference type="OrthoDB" id="912218at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="413" mass="43553" checksum="634F07FD60D67CA4" modified="2006-07-11" version="1">MKKRLGDILLERGVVDALQLHSALAYQRKWGVPLGQVVVDQRFSTTQQVLEALAFQAGMQTVDLDVQPPDASLTWLIPERVAEAHRVVPLKLEGQGGRDSVLVVAIAAPASLASLDAVKSVSGKPRVVAKLASDASIRRAIGQLYRGETGEAVPRRPGMESFSLPEADESMPMVLGGSMAELTNMEAPGGEDGLPLLSSLEEVVVQAQAVPAEMRRLVQAIRAMPEPLAAVAQPLPLEAGRPEQAATPATTEGLHLTHVSRPGSTKAPFSARAMQRTAGTRNHVPSALPVLTAAQPVPMAQVLVYGWGEEATTGLVRVMSQAGLRAQVASTEELLAANAAQVVVAPLPAMESLPRPVHAQVLVAGKMPEQDLPRAQAVGARGFLAAPVDPDLLLRAVRRLARPAGDADLKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVM2</accession>
    <name>Q1CVM2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7446"/>
    <dbReference type="EnsemblBacteria" id="ABF90641">
        <property type="protein sequence ID" value="ABF90641"/>
        <property type="gene ID" value="MXAN_7446"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7446"/>
    <dbReference type="HOGENOM" id="CLU_3357245_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="36" mass="4001" checksum="82A3B0AADFCACD5F" modified="2006-07-11" version="1">MTRDSHRLPDRAFHRALPRWSGGAREALPTASVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVQ3</accession>
    <name>Q1CVQ3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mobB/FdhD</name>
        <name evidence="3" type="synonym">fdhD</name>
        <name evidence="5" type="ORF">MXAN_7414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557325.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7414"/>
    <dbReference type="EnsemblBacteria" id="ABF91740">
        <property type="protein sequence ID" value="ABF91740"/>
        <property type="gene ID" value="MXAN_7414"/>
    </dbReference>
    <dbReference type="GeneID" id="41364570"/>
    <dbReference type="KEGG" id="mxa:MXAN_7414"/>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602470_0_0_7"/>
    <dbReference type="OMA" id="EGWKDGP"/>
    <dbReference type="OrthoDB" id="948173at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="4">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Mo-bisPGD binding" evidence="3">
        <location>
            <begin position="445"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="466" mass="48889" checksum="37586C9AAFC95873" modified="2006-07-11" version="1">MSRVPALSVVGWSGAGKTTLLTRLVPELAARGLRVAVVKHSSDAHPLHRPGSDTARYQDAGAVLTGFTTPAGVQLTTATALSDALPSLLERSAGAVELVLVEGWKDGPLPKLEVWREGLGPPLAPSRPEVLAVLSSEPALPTDFPPGLRVLHPDDVRAVADLILAHLRPSRPAPLPPVDARGVTRRFVQRWNGATLLPAQEDDIAVEEPLEIRVSGDSVATTMRTPGHDRELATGFLFAEGILQSVDDLGGLAHCGRPGEEGFGNVIEVTPAPGAFLDVERVSTARRGTLTTSACGVCGRRSVDDLLAVCPALPPGPVLHPDAVARATERLRDVQRNFARTGGVHAAAVLDANGHLLAAHEDVGRHNAVDKVVGTLVLAGTVRGPRAPRLPLTRQPVVLAVSGRVSFEIIQKAAMARIPIVAGVSAASSLAVDLALRSGMTLAAFVRNERFNVYTGLERLVAGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW67</accession>
    <name>Q1CW67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557162.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7243"/>
    <dbReference type="EnsemblBacteria" id="ABF92436">
        <property type="protein sequence ID" value="ABF92436"/>
        <property type="gene ID" value="MXAN_7243"/>
    </dbReference>
    <dbReference type="GeneID" id="41364409"/>
    <dbReference type="KEGG" id="mxa:MXAN_7243"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015395_1_1_7"/>
    <dbReference type="OMA" id="SDEMYTI"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28484" checksum="0D1E2B742C1E7E58" modified="2006-07-11" version="1">MKQAGGWPLRAWLTAFRLLRRYHRYEVVNLEPLLRPGAKLIVGYHGRPLAVDLCMLTVTLHERLGYLPHGVAHGAFDSIPGMRAVADGLGFVTGDDPRLAEAVARGEHVLLQPGGTREGCRDFRHRYRVDWGERMGYLRLAVRYRLPIVPVGGCGMDDAYVGLNDGYALGRRVGMPARLPLWLGVGATGLWPLSLPFPVKMTQWVGEPLTRHLEPGFDAGNRDAMRAVHQEVADAVQRLLDKARDVDKGSRRKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD9</accession>
    <name>Q1CWD9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557090.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7171"/>
    <dbReference type="EnsemblBacteria" id="ABF93109">
        <property type="protein sequence ID" value="ABF93109"/>
        <property type="gene ID" value="MXAN_7171"/>
    </dbReference>
    <dbReference type="GeneID" id="41364345"/>
    <dbReference type="KEGG" id="mxa:MXAN_7171"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_353280_0_0_7"/>
    <dbReference type="OMA" id="MGFATYP"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187714" evidence="2">
        <location>
            <begin position="24"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="741" mass="80289" checksum="E8BE6FEC0077C692" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWU8</accession>
    <name>Q1CWU8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556931.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7012"/>
    <dbReference type="EnsemblBacteria" id="ABF86109">
        <property type="protein sequence ID" value="ABF86109"/>
        <property type="gene ID" value="MXAN_7012"/>
    </dbReference>
    <dbReference type="GeneID" id="41364187"/>
    <dbReference type="KEGG" id="mxa:MXAN_7012"/>
    <dbReference type="HOGENOM" id="CLU_1426604_0_0_7"/>
    <dbReference type="OMA" id="MAFRVGV"/>
    <dbReference type="OrthoDB" id="1783466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="21531" checksum="E3D01154C730E0D8" modified="2006-07-11" version="1">MRKQSMWVAVVGVLCVGTDAVATGWNGYASLGAGITLDHLSSFRTKGPALHGYLGLETPPGLSVGVLAEISETWGQQFPDAMRQGRLERSQLDYRAVGIEARLRFFQDKPITPWVGARLSKSWGSTFTPDDVGTWLRQNIDTTSMAFRVGVDGWFSDRWGVSVSTGFQFCDVKLTSNALNQCAKLMQSVIAGPVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWV3</accession>
    <name>Q1CWV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86538">
        <property type="protein sequence ID" value="ABF86538"/>
        <property type="gene ID" value="MXAN_7007"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7007"/>
    <dbReference type="HOGENOM" id="CLU_3186175_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="46" mass="4969" checksum="AD310E12A2AB4C4C" modified="2006-07-11" version="1">MMALPGTPPSLLVTVDGVQVELEVDDAQRRLTVRDVTLSPNLRHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWY7</accession>
    <name>Q1CWY7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6971"/>
    <dbReference type="EnsemblBacteria" id="ABF90471">
        <property type="protein sequence ID" value="ABF90471"/>
        <property type="gene ID" value="MXAN_6971"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6971"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_7"/>
    <dbReference type="OMA" id="ACIYVED"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="182"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="44409" checksum="BC4DE651D2BFBDA3" modified="2006-07-11" version="1">MTVTVGIATEGGGIATPPSGGGSRPVELAELMSTVPLGMAIIDRELRFVEVSDAMAAMHGVSREAHLGQPMVEVLRAEPSAADVVRRVRRVLETGVALEGVEIIHRESGAHGERTRVYRASYHPVRRDGAIVAACIYVEDMTERRRVEAQRDAGAARERSVREQALRETQEAVRARDEFLSVAAHELRTPLTSLRLHLQLLLRQVGGSNQEPPAELAPRARVLDRQLSRLVGLVNTLLDVSRLAAGRLSLEPRELDLAQMVRQMAEAFSEEFTRAGSTLSLHVDGPLLGEWDSLRLEQVLVNLLSNAVKYGGGQPVEVSLASEGPTAVLAVKDQGIGISEDGMARLFGKFERAVSERHYGGLGLGLYITRQIVEAMGGSITVRSAQGKGSTFILRLPTRPPVPSKAAVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX13</accession>
    <name>Q1CX13_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88387">
        <property type="protein sequence ID" value="ABF88387"/>
        <property type="gene ID" value="MXAN_6945"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6945"/>
    <dbReference type="HOGENOM" id="CLU_1174418_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25064" checksum="31E072C3BB7CC945" modified="2006-07-11" version="1">MRGPRGADGARGCSSAFSRCWGREFRAAARESKSSNQRTHPVNTSFIRWPCALAGLSLGALLVACGGDSEPSNPNGDGDGNGEEGPVTETIVNGRPASEYYAQFAYEKYAGAPGGAAAFPAQQDGINLFAATAYLKQDKSFILYYAEGAGTVRSNGYSAEIPTSRMFKRTGTWSVSGGSLKLGDLMTCQGLMVNGNDALRCTLDRTIGYSEAVGKSATFTRSTNTSPNDRQWADYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX58</accession>
    <name>Q1CX58_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556821.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6901"/>
    <dbReference type="EnsemblBacteria" id="ABF90365">
        <property type="protein sequence ID" value="ABF90365"/>
        <property type="gene ID" value="MXAN_6901"/>
    </dbReference>
    <dbReference type="GeneID" id="41364084"/>
    <dbReference type="KEGG" id="mxa:MXAN_6901"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1271170_0_0_7"/>
    <dbReference type="OMA" id="SEYQDEP"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="24649" checksum="5D42619738C51B97" modified="2006-07-11" version="1">MPSFVRMSEPKGKAKRTSELVPGVHHWTLSDDRIGGARSDAYAVVDTDGAVVLIDPLPIDEEALRKLGNISAIVLTAGNHQRSAWRLRKAFKVPVWAPEGAQTLEEQPDFFYVAGDTLPGGLISFHTPGPTEAMYTLWMQQHPRAVAFISDLLTHEDGETPEFIPSEYQDEPLRTRHSVQRILDHLPVETLCFSHGAPILRDGSRALRLALEEDMESPAAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXB6</accession>
    <name>Q1CXB6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556765.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6840"/>
    <dbReference type="EnsemblBacteria" id="ABF91596">
        <property type="protein sequence ID" value="ABF91596"/>
        <property type="gene ID" value="MXAN_6840"/>
    </dbReference>
    <dbReference type="GeneID" id="41364029"/>
    <dbReference type="KEGG" id="mxa:MXAN_6840"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782619_0_0_7"/>
    <dbReference type="OMA" id="EHACAHA"/>
    <dbReference type="OrthoDB" id="1076983at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="88"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="36991" checksum="50AD6CF10205A527" modified="2006-07-11" version="1">MTWASPQPLHRGAPLTSGGAPALLPAPPHQGPPMRTVATTTLLATCALLALAGCDNDDPVPPTPDAGTRPDAGTEPDAGTQPDAGSVQGPTVIGSTPSEGETNVLPVELFKADATTTGVRKLVTLTFDTPMDTTAADVTLVDRTTPANAPRTLTGTWTEDGLTLSVAIPRPESDLPPLEEETAYTLELGALRGAEGHAVDTSHAGLGDGRLDFTTGRRDGTTEHACAHALLESPVPVTASASPTIYPATDTSHEFYGLTLPASGTSFLGYTEVVSGESRDEPVILYLNHPIPVAVHDTTEGEDAIATALEPARPVCLPAITHTLKFTAPGGDRFLRLTFGPTERETFTFVFERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXD0</accession>
    <name>Q1CXD0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sodium ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556751.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6826"/>
    <dbReference type="EnsemblBacteria" id="ABF85891">
        <property type="protein sequence ID" value="ABF85891"/>
        <property type="gene ID" value="MXAN_6826"/>
    </dbReference>
    <dbReference type="GeneID" id="41364015"/>
    <dbReference type="KEGG" id="mxa:MXAN_6826"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022118_2_0_7"/>
    <dbReference type="OMA" id="KDAFRDR"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF85891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="42276" checksum="705945D569FF4A44" modified="2006-07-11" version="1">MSGLSFSVFRKELKDHLRDRRSVLTSLMWPLIGPVVFMVMFNLLASWYRQDRPLALPVVGREHAPSLMAFLERYGAQLEAAPEDYESRIRAGSLDAVLVVPDDYAESYSAGRTAEVQLVVDSSRQSARQSVLRARRLLEAYAHMLGNQRLYARGVSPDLAIPVRVQEADLSTPERTAAGLLNMVPLFLVIAAFAGGMQVASDAMAGERERGSLEPLLLNPAPRRAVVTGKWLATVVMAVAAVLITLVGYMLVVRRVPLEDLGVKARFDAPAALGMAAAVLPLALAASAVQVWVSTYARSFKEAQTYLSLLMVVPMLPGMVLALSPLQPKMWMFAVPVLGQEVLAGEVMRGEPLGALPFLIAGASSILLTVLSLAVTARLLSQERIVFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI7</accession>
    <name>Q1CXI7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556694.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6768"/>
    <dbReference type="EnsemblBacteria" id="ABF87872">
        <property type="protein sequence ID" value="ABF87872"/>
        <property type="gene ID" value="MXAN_6768"/>
    </dbReference>
    <dbReference type="GeneID" id="41363959"/>
    <dbReference type="KEGG" id="mxa:MXAN_6768"/>
    <dbReference type="eggNOG" id="ENOG5033M8B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007709_0_0_7"/>
    <dbReference type="OMA" id="LREVWFD"/>
    <dbReference type="OrthoDB" id="946623at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="32495" checksum="CC3D36A916CCC5CA" modified="2006-07-11" version="1">MQRMRASFLIRGVDGRLRHGKALFSGLAYSLRHDGTLDSLMAASEGVITGPSPDWLPLPEGGLRVNSALLEMPEDYGPRLFQGRPFTGVAYAFTRNGYCTSEVEYAGGFATEVSERRWYVSGQPKMHVDGGEYTSWFPDGRIQRRGLKGELVYGLNTRDDGHLRELVLRDASFLDMEILSALTPTEEFQMLGGAVDTAMLHTLREQTDIGAVPRLRLVQTRVGAEGVEILAAFKNLREVWFDGNPGLGLQEARKLERLRPGCVAHHVDPDALPPVRRPRVLSSAANGHTARPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ8</accession>
    <name>Q1CXJ8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6758"/>
    <dbReference type="EnsemblBacteria" id="ABF86061">
        <property type="protein sequence ID" value="ABF86061"/>
        <property type="gene ID" value="MXAN_6758"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6758"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288244_0_0_7"/>
    <dbReference type="OMA" id="MAGNPAC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="23326" checksum="9D9DBD472B4A67DD" modified="2006-07-11" version="1">MEPMAGNPACERFVPMLSPYVDGELSSGERVNVERHLAACRDCTGRAADLRAESGLLRVGLDMAVDDVDFKDFTQRVMARVTPDKPPLMERLKLAVSEMFLYQRTAMISSLATAAVLLLVGVPLLTSDRAPVGYASERMTVKSIQPYRNAQVAPVVMETDNGGTIIWLVDEDSDVLSPGAEKGERQDQTGVGQPDASGRNVPARPAPDAPRPSGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM6</accession>
    <name>Q1CXM6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91550">
        <property type="protein sequence ID" value="ABF91550"/>
        <property type="gene ID" value="MXAN_6730"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6730"/>
    <dbReference type="HOGENOM" id="CLU_3186174_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="46" mass="5109" checksum="45246CB1B9433CF0" modified="2006-07-11" version="1">MSTYIGARRSGLRTIARHFQTPEAIPTASKAPAARMEVPSILIRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXS4</accession>
    <name>Q1CXS4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556607.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6682"/>
    <dbReference type="EnsemblBacteria" id="ABF92838">
        <property type="protein sequence ID" value="ABF92838"/>
        <property type="gene ID" value="MXAN_6682"/>
    </dbReference>
    <dbReference type="GeneID" id="41363875"/>
    <dbReference type="KEGG" id="mxa:MXAN_6682"/>
    <dbReference type="HOGENOM" id="CLU_1110495_0_0_7"/>
    <dbReference type="OMA" id="YERWAQA"/>
    <dbReference type="OrthoDB" id="1332600at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27208" checksum="DC45B1308DB37AA0" modified="2006-07-11" version="1">MRNREHALMRWYERHIDASLTRWSLGDLSSHQSARLLRHAHACRRCGTRYERWAQAHRALEGNDIHAPSSVELQALSDGGLEAALAAAAPEQAPSRWPSLALLGGALAAVFLAVVLIPTATTTPGEFVARGEGTAPPGVALRIFCATPGQALRELHAGDACRAGAMLAFAAGGHAPFTHVAVQVRGAKKAEVTAGPFALSGGLGKEAPLELTVPMPETAGTVEVVAVFAGSPAESLATLRGEQTKGTVVLKQSVRVEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY24</accession>
    <name>Q1CY24_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556507.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6577"/>
    <dbReference type="EnsemblBacteria" id="ABF92335">
        <property type="protein sequence ID" value="ABF92335"/>
        <property type="gene ID" value="MXAN_6577"/>
    </dbReference>
    <dbReference type="GeneID" id="41363782"/>
    <dbReference type="KEGG" id="mxa:MXAN_6577"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508730_0_0_7"/>
    <dbReference type="OMA" id="CNAGACE"/>
    <dbReference type="OrthoDB" id="708979at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227">
        <property type="entry name" value="PTHR33227"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="54353" checksum="7A743C4F0559F9CB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYC1</accession>
    <name>Q1CYC1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6480"/>
    <dbReference type="EnsemblBacteria" id="ABF91208">
        <property type="protein sequence ID" value="ABF91208"/>
        <property type="gene ID" value="MXAN_6480"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6480"/>
    <dbReference type="HOGENOM" id="CLU_2288518_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="101" mass="11217" checksum="18A400B1F1C05E4A" modified="2006-07-11" version="1">MRPAEHRAPVAQQLAHALLLEYARIPLQSEGSPASTSVDEFIAANYPKDLKEFLRKVLTAADKAAELDGVSARNKVWWPIVKAVVRATVKVVEAVNQRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYC9</accession>
    <name>Q1CYC9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556402.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6472"/>
    <dbReference type="EnsemblBacteria" id="ABF89923">
        <property type="protein sequence ID" value="ABF89923"/>
        <property type="gene ID" value="MXAN_6472"/>
    </dbReference>
    <dbReference type="GeneID" id="41363679"/>
    <dbReference type="KEGG" id="mxa:MXAN_6472"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473135_0_0_7"/>
    <dbReference type="OMA" id="QRVSAWP"/>
    <dbReference type="OrthoDB" id="314616at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="BatA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="89"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="594" mass="62442" checksum="F38AEE6E36673653" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYL4</accession>
    <name>Q1CYL4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ORF">MXAN_6385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556317.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6385"/>
    <dbReference type="EnsemblBacteria" id="ABF88554">
        <property type="protein sequence ID" value="ABF88554"/>
        <property type="gene ID" value="MXAN_6385"/>
    </dbReference>
    <dbReference type="GeneID" id="41363596"/>
    <dbReference type="KEGG" id="mxa:MXAN_6385"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_7"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="368" mass="39507" checksum="70A341A111541240" modified="2006-07-11" version="1">MKVHGKPMRSIWLAPDAQAAEAIDQTRLPHALVSVRLTTLDEAAHAIRSMLVRGAPLIGATAAYGVWLALRADASDGALEHALAVLRGTRPTAVNLHWALDDMRQLLAPLPPAERVAAALRRAEAISDEDVAINRAIGAHGLKLLEDAWMRKGRQGRLEVLTHCNAGWLATVDFGTALSPIYQAHDAGIPVHVWVDETRPRNQGAQLTAWELGQHGVPHTVIADNVGGHLMQHGQVDLCIVGTDRTTAQGDVANKIGTYLKALAAKDNGVPFYVALPSPTIDWTLRDGVREIPIEQRDGTELSDVTGRLASGEVATVRITPEGSPAANYAFDVTPARLVTALITERGVCPASHDGLLSLFPERRGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYT4</accession>
    <name>Q1CYT4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YdjC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556247.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6314"/>
    <dbReference type="EnsemblBacteria" id="ABF92991">
        <property type="protein sequence ID" value="ABF92991"/>
        <property type="gene ID" value="MXAN_6314"/>
    </dbReference>
    <dbReference type="GeneID" id="41363530"/>
    <dbReference type="KEGG" id="mxa:MXAN_6314"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_4_0_7"/>
    <dbReference type="OMA" id="IGRDYGM"/>
    <dbReference type="OrthoDB" id="1204930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="26559" checksum="9299665096120D15" modified="2006-07-11" version="1">MPSRALIINADDLGYDPAVTRGILRSMREGVVSSATFMVNTPFSEAAAREARGLSIGLHLNLARGAPVWSGFPRELLGEDGGFVEARAGSLPADAVEAESFAQLARLAGLLGLPATHVDVHKHLHLHAGVLEGLARAARSVGVPVRSINAEMRRTLRAQGVATNAHFVGDAGAEAYWTLERFASELAALPQDGVIELMCHPGYRPETLKSGYAAQREVELETFLHPQAREVLARAGIVPVDFRVLTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYX2</accession>
    <name>Q1CYX2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556212.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6274"/>
    <dbReference type="EnsemblBacteria" id="ABF92248">
        <property type="protein sequence ID" value="ABF92248"/>
        <property type="gene ID" value="MXAN_6274"/>
    </dbReference>
    <dbReference type="GeneID" id="41363494"/>
    <dbReference type="KEGG" id="mxa:MXAN_6274"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456961_0_0_7"/>
    <dbReference type="OMA" id="WTSSPWF"/>
    <dbReference type="OrthoDB" id="1284944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="597" mass="63021" checksum="BC6DA221D6B084D9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYZ7</accession>
    <name>Q1CYZ7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556189.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CYZ7"/>
    <dbReference type="STRING" id="246197.MXAN_6247"/>
    <dbReference type="EnsemblBacteria" id="ABF90553">
        <property type="protein sequence ID" value="ABF90553"/>
        <property type="gene ID" value="MXAN_6247"/>
    </dbReference>
    <dbReference type="GeneID" id="41363469"/>
    <dbReference type="KEGG" id="mxa:MXAN_6247"/>
    <dbReference type="eggNOG" id="ENOG502Z881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372108_0_0_7"/>
    <dbReference type="OMA" id="RLPLFMP"/>
    <dbReference type="OrthoDB" id="1869158at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0456">Lyase</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="755" mass="85003" checksum="96FCD14357ABD416" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ38</accession>
    <name>Q1CZ38_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6204</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6204"/>
    <dbReference type="EnsemblBacteria" id="ABF90157">
        <property type="protein sequence ID" value="ABF90157"/>
        <property type="gene ID" value="MXAN_6204"/>
    </dbReference>
    <dbReference type="GeneID" id="41363432"/>
    <dbReference type="KEGG" id="mxa:MXAN_6204"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027555_0_0_7"/>
    <dbReference type="OMA" id="FDLCAQR"/>
    <dbReference type="OrthoDB" id="618655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="524" mass="54369" checksum="7296A88BD3949FDB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZG0</accession>
    <name>Q1CZG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6078"/>
    <dbReference type="EnsemblBacteria" id="ABF86508">
        <property type="protein sequence ID" value="ABF86508"/>
        <property type="gene ID" value="MXAN_6078"/>
    </dbReference>
    <dbReference type="GeneID" id="41363314"/>
    <dbReference type="KEGG" id="mxa:MXAN_6078"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077373_0_0_7"/>
    <dbReference type="OMA" id="GLGIDCR"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="24591" checksum="36325281AF954A8F" modified="2006-07-11" version="1">MSGPLFPRWTNTVSRLSAAALLAVPAIGIGGLMAYVRSPYVTGQQRPIEQPIEFDHRHHAGDEQIDCRYCHWSVEESPSAGIPSTTVCMSCHAQVWNKSPYLTEVRKAFFSDQPIPWVRVHNLPDFVYFNHSIHVAKGVGCATCHGRVDQMAAVEQAAPLTMAWCLDCHRNPEPHLRPAEFITSMTWTPPEDKAKAAELGRQLAEAYDVHSRESCSTCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY1</accession>
    <name>Q1CZY1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative twin-arginine translocation protein TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555856.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CZY1"/>
    <dbReference type="STRING" id="246197.MXAN_5905"/>
    <dbReference type="TCDB" id="2.A.64.1.2">
        <property type="family name" value="the twin arginine targeting (tat) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87301">
        <property type="protein sequence ID" value="ABF87301"/>
        <property type="gene ID" value="MXAN_5905"/>
    </dbReference>
    <dbReference type="GeneID" id="41363143"/>
    <dbReference type="KEGG" id="mxa:MXAN_5905"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651105_0_0_7"/>
    <dbReference type="OMA" id="EREFYAM"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="18887" checksum="FB61920081458A1B" modified="2006-07-11" version="1">MFNIGAGEMVFILVAALLILGPQRLPELARGIGKFLREFRRQTDEVRNVVEREFYAMDQEIGEPPTAPLRPGTRFAPQPPQAVGGPEATLPPATDGASPPADAASPQPSSPAQVLEMDAQGPREVATSDVHAGETPAQDAATAEPGAEPTAEAPPEPAASTATSPTLSPIPGTVARNAPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D088</accession>
    <name>Q1D088_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF91062">
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        <property type="gene ID" value="MXAN_5798"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5798"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="RFWGELG"/>
    <dbReference type="Proteomes" id="UP000002402">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="382" mass="40489" checksum="2B34DBECD0A99C50" modified="2006-07-11" version="1">MANSCMALHMEDSGSCPLPPWGLARFCRSGCLFRPGDALGRARRGARTRAACPRHSGSGSAPGAPITGASRLLHGSRTGRNRAIRSGMWPSWGNVRVSRRAHQVSFTSRLEGLLQNVGLGGIVGEVRARLGLKEPRDTSAPRASDFPSPPPRGATQQTVVERTPRPRPVVSQPSDAPPSEPTVAERTPPRGAVTTDAVAPSAAQAATPEPSRKVTAKAPRTGAKKKKPATRQVQSSTGAKSEKRTARPATKTKKRARPDKKAGSPATGNGGTAVDQLLSALRSHPRQQDFIAAGKQKDQLVRSLIPLYLARSLDAEFEVTSGTTSRFWGELGFTYAAPNAAKALRLHGGYAQDTQKGKAITARGVQYVEEMLSRFGNASSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0E8</accession>
    <name>Q1D0E8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555689.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5738"/>
    <dbReference type="EnsemblBacteria" id="ABF92337">
        <property type="protein sequence ID" value="ABF92337"/>
        <property type="gene ID" value="MXAN_5738"/>
    </dbReference>
    <dbReference type="GeneID" id="41362981"/>
    <dbReference type="KEGG" id="mxa:MXAN_5738"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874093_0_0_7"/>
    <dbReference type="OMA" id="GRWYVWA"/>
    <dbReference type="OrthoDB" id="1326086at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188217" evidence="2">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="3">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="36039" checksum="6C3A6753F9CE1B97" modified="2006-07-11" version="1">MSLHRIVVFALVTVLAAPSAALAQDDFLAPLTAPSKPKTGKPKVVKKKPAKKPARAKAPPKGSKKPAAEDDLLLAPLTPVKTEVLVRMTGNVRGAKLFVDGKEFGVLSSAAVPVEVRPGEHHLVVRRQGYADFTRRIDVKSGTQAEVLVSMDATMGFATLTADVADAVVMVDGQQVGAVPQANVLLRPGSREIEFRAPGFKPDVHNITVFAGRTYEVTGNLRPLLDTSVATADVPKNPVLEPSSKLDPDDETAPGLSFAGDPETPEVEGSKPWYGRWYVWAGIGAVVAAGTVGAVMATQGGGASPLSPDDVCRPANCDAVLGGIRSVRGGGVRLQAPPPAGAIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0F7</accession>
    <name>Q1D0F7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rnhA</name>
        <name evidence="3" type="ORF">MXAN_5728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5728"/>
    <dbReference type="EnsemblBacteria" id="ABF85946">
        <property type="protein sequence ID" value="ABF85946"/>
        <property type="gene ID" value="MXAN_5728"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5728"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095977_0_3_7"/>
    <dbReference type="OMA" id="RHRNTEA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="15941" checksum="885959A7F10613BC" modified="2006-07-11" version="1">MSPPVDAAPDSESHPRLRVYSDGAARGNPGPAGAGAVLMDPAGNVVARLGRFLGHQTNNCAEYMGLLLGLKHAQSLGAREVEVFADSELLIRQLGGRYQVKSPTLKPLYEEARKLLKGFTKVKLHHVPRAQNAEADEMSNRAIDERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K0</accession>
    <name>Q1D0K0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555638.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5685"/>
    <dbReference type="EnsemblBacteria" id="ABF89009">
        <property type="protein sequence ID" value="ABF89009"/>
        <property type="gene ID" value="MXAN_5685"/>
    </dbReference>
    <dbReference type="GeneID" id="41362930"/>
    <dbReference type="KEGG" id="mxa:MXAN_5685"/>
    <dbReference type="HOGENOM" id="CLU_1025692_0_0_7"/>
    <dbReference type="OMA" id="EERRCAC"/>
    <dbReference type="OrthoDB" id="811391at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="30765" checksum="BDA97E58E0289D9F" modified="2006-07-11" version="1">MIAQLLAATLALTSSQAPVSVSGRGSPQVNLPFPSGDVQTYNIIQWDPNQLPRIYERSDQLPLTDEELTKLSQAGFEPAQLVKMIEERRCACDASADGLIRLKKAGVDKDVLAAVSRHGLAPNRGLNLLVTLDFTGESRNAREAFLYFFVDDGDITRVFTANIPELLRRRNSHETTVDRSDILVARTVRRVQLAGQVPLRTYGKHNVLVVASASPTLTHPSQLTAQELSRSQRYTFDYPRASLQNVCRLTAGYRRDAVLAYKWNFEGSRFECEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0M7</accession>
    <name>Q1D0M7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555611.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5658"/>
    <dbReference type="EnsemblBacteria" id="ABF92859">
        <property type="protein sequence ID" value="ABF92859"/>
        <property type="gene ID" value="MXAN_5658"/>
    </dbReference>
    <dbReference type="GeneID" id="41362903"/>
    <dbReference type="KEGG" id="mxa:MXAN_5658"/>
    <dbReference type="eggNOG" id="ENOG50320EI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1946495_0_0_7"/>
    <dbReference type="OMA" id="VIRLWGV"/>
    <dbReference type="OrthoDB" id="1869514at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="14176" checksum="F143B3C6AF3573F0" modified="2006-07-11" version="1">MPGGRGPVFSVEALVGKNRLVIRLWGVVTEEEALQIGDASLRELERLRPGFDILSDLTGVTELPESGSGQIERVVEAARVRGFRRVVRVVGRSAMAAVRFQRSSRNVGHEAYLAFSLEEAEQLLEGGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0P1</accession>
    <name>Q1D0P1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type III secretion protein, FHIPEP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555597.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5643"/>
    <dbReference type="EnsemblBacteria" id="ABF91906">
        <property type="protein sequence ID" value="ABF91906"/>
        <property type="gene ID" value="MXAN_5643"/>
    </dbReference>
    <dbReference type="GeneID" id="41362889"/>
    <dbReference type="KEGG" id="mxa:MXAN_5643"/>
    <dbReference type="eggNOG" id="COG4789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_7"/>
    <dbReference type="OMA" id="WDLAFHQ"/>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="688" mass="71968" checksum="030BFED290DC35D2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R0</accession>
    <name>Q1D0R0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555578.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5624"/>
    <dbReference type="EnsemblBacteria" id="ABF88922">
        <property type="protein sequence ID" value="ABF88922"/>
        <property type="gene ID" value="MXAN_5624"/>
    </dbReference>
    <dbReference type="GeneID" id="41362870"/>
    <dbReference type="KEGG" id="mxa:MXAN_5624"/>
    <dbReference type="HOGENOM" id="CLU_879149_0_0_7"/>
    <dbReference type="OMA" id="APEWHEI"/>
    <dbReference type="OrthoDB" id="1061309at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="34980" checksum="685AFB4750E5F1F0" modified="2006-07-11" version="1">MRSPSITRALPLVELGGLLLVAFLCLLFHLRLPGRLPSEADYRAVAERLQAEAQPGDAVLLFPWWTERARIFVPSTLPVYGYLGSDQDDLSAHPRVWVLGQPELPRSDEAGFLETFLRGRRAVGAPSRHGTLTLALYENGRHRPRRFTATEAYARARVYLEQPDGTRRDCPFDGKVHRCPGPAHLYVAPEWHEILYEPRRCLWMHAPGGKQRLVAELDGVPGGLGLRLEGGIIFEHAFPKDSRFSTTHLGVDDAANGARLLSLAIPPGLEGVQKAEVRLPEGAPHTVKVWVQADNADRRQVCLDVLAVEPEVGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D169</accession>
    <name>Q1D169_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555419.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5461"/>
    <dbReference type="EnsemblBacteria" id="ABF89451">
        <property type="protein sequence ID" value="ABF89451"/>
        <property type="gene ID" value="MXAN_5461"/>
    </dbReference>
    <dbReference type="GeneID" id="41362717"/>
    <dbReference type="KEGG" id="mxa:MXAN_5461"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043118_0_0_7"/>
    <dbReference type="OMA" id="PYDCWRR"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="362" mass="40417" checksum="B997FCB4F4DA4D2B" modified="2006-07-11" version="1">MPSDASTVSDSRAQSRDWRARTQRSVVQLVGCVGAYVLLAGASYVFFAQSLVGGVALAVLAGVVLVRVFILQHDCAHRSLFQRPVTNDRVGVVLGMLTLAPHAYWRAMHLVHHSTSGDLDRRGVGDIVTMTAQEYLALKPSQRLRYRLYRHPAVLLGVGPIFQFLLRFRMPGIVAKERRPERRSILVTNLALVAVHLAFLALGDWPRWLVVHLIITQVAAGLGIWLFFVQHQVERPYWVPRAQWSLKGSALQGSSHLVLPRAFEWLFGAINLHHVHHLKPQIPNYLLRGYMEQHGLAEEGVKLGLRDSVRAFRLKVYDEATGRMTGFPPVHAGQARTPLASPPSIEPTGQLGRVLTFSGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L9</accession>
    <name>Q1D1L9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555269.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92771">
        <property type="protein sequence ID" value="ABF92771"/>
        <property type="gene ID" value="MXAN_5303"/>
    </dbReference>
    <dbReference type="GeneID" id="41362573"/>
    <dbReference type="KEGG" id="mxa:MXAN_5303"/>
    <dbReference type="eggNOG" id="ENOG5033EJ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1702352_0_0_7"/>
    <dbReference type="OMA" id="CEMRWED"/>
    <dbReference type="OrthoDB" id="1815637at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="18091" checksum="8540BC912FF06ED9" modified="2006-07-11" version="1">MADVCRRACPIMSSAVDTRALTERLTIATPCEMRWEDMKGDARVRHCGACRLSVHNLSEMTTLEVESLLQPGGSVCVRLYRRPDGTVVTGDCRRIWSQQREEAVTLLGTAATVVAAFSFLVLIGLLTITLYGDHIRRMFGSATAGALPATLPPAVSAPSPLLGGHRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T8</accession>
    <name>Q1D1T8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5233"/>
    <dbReference type="EnsemblBacteria" id="ABF87050">
        <property type="protein sequence ID" value="ABF87050"/>
        <property type="gene ID" value="MXAN_5233"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5233"/>
    <dbReference type="eggNOG" id="ENOG5032V9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624395_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="20795" checksum="6FD1CD8957D35115" modified="2006-07-11" version="1">MANASSRPSPLLSRPSLKRVRDAANLLASLAPGVLFVMALLVVSQQTRFSWLAEPLHYPWEFWVVGLAGTTATAAGVADWRYHRVARLRVGPREHQAEFLALAGGGLPLFLLMCAASVAHRPQMYLLPVLVVLIGTVALICYDEFVFHRRRCDRWEALLHRTLLAGHAAAFLAWAHFCFVRENLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D208</accession>
    <name>Q1D208_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86391">
        <property type="protein sequence ID" value="ABF86391"/>
        <property type="gene ID" value="MXAN_5162"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5162"/>
    <dbReference type="eggNOG" id="ENOG5032QXM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982909_0_0_7"/>
    <dbReference type="OMA" id="GKWKFFT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="28825" checksum="DCB7FB9AC9C35482" modified="2006-07-11" version="1">MTSPSTPSPSSSSHQKAAAERRNPERAACLLDYNGRAMNRTALLSLCVAASLVACTERTSSPAAGVDSGIAAAPVAPATPGKGQTPSPAPNTEPQGAGSPDAAVPGSATAEAANADSGVGEYTGAPAAEKGTCSAASLSPRAAPASPALPAPVESMRQRIIAAAVACDYTALNTLADENGKAVRFTFGDGTDAGEYWRAAEKLGNPELARIVKVLNLPYAKQDNLYFWPAVHVTGATSDKDWGALKGVYPDEEIAGMKDQGSYLGLRVGITPEGDWQIAVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D259</accession>
    <name>Q1D259_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">argC</name>
        <name evidence="7" type="ORF">MXAN_5110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555084.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5110"/>
    <dbReference type="EnsemblBacteria" id="ABF86440">
        <property type="protein sequence ID" value="ABF86440"/>
        <property type="gene ID" value="MXAN_5110"/>
    </dbReference>
    <dbReference type="GeneID" id="41362394"/>
    <dbReference type="KEGG" id="mxa:MXAN_5110"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_7"/>
    <dbReference type="OMA" id="GTHHPTR"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="38112" checksum="66EA2C0C830F9628" modified="2006-07-11" version="1">MTQVNIYILGASGFGGGELLRILSGHPAVGSIRAVSRHHAGEPIHKVHPHLRGLVEGRFEGEPDWKWLADCEQPVVFSALGHGDLAKQFAGLEKQWAEVGIAERLLLVDLSSDFRLDHPGRYAGAYGRPHPSPELLGTFTYGLTEWKRDAVKTAKRIANPGCFATAVQLALLPIASTPGLGLLAVSGVTGSSGSGSLPGEGTHHPTRAQDFRAYKPLEHQHEAEVEVMLVAHGAQRHRLAFVPHSAPMVRGIFATVQFEWPEHGGAVVTASLMEKYRRYYEGSKFVRIVEGTPRIAAVAGSNFCDIAVATKGRSVAVMAALDNLVKGMAGQAVQNFNVALGLPEDTALRQAACYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3E8</accession>
    <name>Q1D3E8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554651.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4659"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90848">
        <property type="protein sequence ID" value="ABF90848"/>
        <property type="gene ID" value="MXAN_4659"/>
    </dbReference>
    <dbReference type="GeneID" id="41361959"/>
    <dbReference type="KEGG" id="mxa:MXAN_4659"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398926_0_0_7"/>
    <dbReference type="OMA" id="FNQPTAW"/>
    <dbReference type="OrthoDB" id="140433at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="694" mass="77158" checksum="632D99AD784D4536" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D441</accession>
    <name>Q1D441_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554410.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4411"/>
    <dbReference type="EnsemblBacteria" id="ABF90729">
        <property type="protein sequence ID" value="ABF90729"/>
        <property type="gene ID" value="MXAN_4411"/>
    </dbReference>
    <dbReference type="GeneID" id="41361724"/>
    <dbReference type="KEGG" id="mxa:MXAN_4411"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_3_3_7"/>
    <dbReference type="OMA" id="HYDMDLA"/>
    <dbReference type="OrthoDB" id="1885303at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="114"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="33811" checksum="F63E38B7EFFF140C" modified="2006-07-11" version="1">MNAKHPIAIERISSPTPAFFREHYLEKRRPVVLTGVVSHWPAVTRWSADSFKQRFGDHRVVVERSRASVPSNDPLEFLRNRYYEEARLGDTIARMMSGEHPPGAYYVTYANIFDAAPELLGDFESPPQTWGIPPHYPRALQDRLTLRPGFWLGPAGTVSAVHFDRQENFNAQISGRKKWTLYSPQDSRHLYYPALDMPTVIFSPVDIEAPDARRFPRFAEAQPYETILEPGELLFIPAGWWHHVRTLELSISLNFWWWTLASVGTTARVNYHFARKQLLRILGRQGATAASMPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F8</accession>
    <name>Q1D4F8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554293.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4290"/>
    <dbReference type="EnsemblBacteria" id="ABF87447">
        <property type="protein sequence ID" value="ABF87447"/>
        <property type="gene ID" value="MXAN_4290"/>
    </dbReference>
    <dbReference type="GeneID" id="41361601"/>
    <dbReference type="KEGG" id="mxa:MXAN_4290"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_1_7"/>
    <dbReference type="OMA" id="ALCRLIC"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="29112" checksum="0786257EF7FB109D" modified="2006-07-11" version="1">MNPESSIAAAESPWLVRRKPQASPRLRLFCFPYAGAGSLPYFRWPDLLPEADIEVCAVQPPGRENRLHEPSVEELPQLLDALVRELSPLFDGPFAFFGHSLGALIAFELTRELRRRGLPLPGTLLVSGSEAPSRRSGLPPLSGLRRDDFIRELSARYDGIPQQVLAQPEILDLILPILRADLKISERYTYQEEPPLPVRLCAFGGTRDPRVSEAALDTWRLQTQQSFSMKMFPGGHFFLNELTAQVVQAVHAELAVGATPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4L9</accession>
    <name>Q1D4L9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 10" type="primary">hisD</name>
        <name evidence="10" type="ORF">MXAN_4229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 9">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88319.1"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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        <property type="protein sequence ID" value="ABF88319"/>
        <property type="gene ID" value="MXAN_4229"/>
    </dbReference>
    <dbReference type="GeneID" id="41361546"/>
    <dbReference type="KEGG" id="mxa:MXAN_4229"/>
    <dbReference type="eggNOG" id="COG0141">
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    </dbReference>
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        <property type="reaction ID" value="UER00014"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
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        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7 8">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="45609" checksum="663B19D9E8C11B9C" modified="2006-07-11" version="1">MTAFLASSTLRYRGPLSALAREDVRRLLDRATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEVPREVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVGVYAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSLGGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQVVGAVAIEAPAGPSEILVVADDTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGSRGAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMTGSNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLADSEGLFAHADAARAWGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D587</accession>
    <name>Q1D587_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, S1C (Protease Do) subfamily</fullName>
            <ecNumber evidence="2">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554016.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4006"/>
    <dbReference type="EnsemblBacteria" id="ABF91042">
        <property type="protein sequence ID" value="ABF91042"/>
        <property type="gene ID" value="MXAN_4006"/>
    </dbReference>
    <dbReference type="GeneID" id="41361337"/>
    <dbReference type="KEGG" id="mxa:MXAN_4006"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609313_0_0_7"/>
    <dbReference type="OMA" id="FLKCWGD"/>
    <dbReference type="OrthoDB" id="914693at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188250" evidence="1">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="440" mass="47436" checksum="79F8BA117A34A3AC" modified="2006-07-11" version="1">MFAFILAAVLTQSPVVPAAPSPPPAPGTPEAVPAVPLSTLPPATHELFQRIEGQVAQVRIIERRSGTRSSIGSAFFVSAAGHAVTNYHVISDVVIHPEDYTAELVLKGGAEPVPVRLVDVDVVHDLAIIQTATPVQSFFDLDDREPPQGARLFAMGNPRDLGTTIVEGTYNGFIHDALYERLHFSGAINPGMSGGPTLTGEGRVVGVNVATMGNQVGFLVPVKHARALLARALEAKDSGAQALLDTVRAQLLDNQQRVTERLLGAPVPQQTLGSYRVPGRWGTFLKCWGDTPHDPEVPYTVTNYQCSSEEDIFVSSRHRTGVVAFLHQHATSQKLGALRFSALYSALFSQDPDAVEATRQDVTNYRCQSEFVDVAGLPVRAALCMRAYRKFPGLYDLVLRAATLNGSTSGVDTSLTLAGFTADNGRKLARRYLEGLSWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A8</accession>
    <name>Q1D5A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553995.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3985"/>
    <dbReference type="EnsemblBacteria" id="ABF89888">
        <property type="protein sequence ID" value="ABF89888"/>
        <property type="gene ID" value="MXAN_3985"/>
    </dbReference>
    <dbReference type="GeneID" id="41361317"/>
    <dbReference type="KEGG" id="mxa:MXAN_3985"/>
    <dbReference type="eggNOG" id="ENOG503295Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2083315_0_0_7"/>
    <dbReference type="OMA" id="PRYVPLM"/>
    <dbReference type="OrthoDB" id="1854740at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="14606" checksum="AA0E3FFD4ECCA29A" modified="2006-07-11" version="1">MSGCQSLRTHSPEGSMQNIFIAGGWGMYPTLLAGIALIATCIQYARRPAPRYVPLMLSLGLCTLIAGTLGFATGILSLLQAYSGPLWDQGPRVLFIGTFEALHNVALALLLAMLGALLASIGAWRISRRMGSFAAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5D2</accession>
    <name>Q1D5D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553971.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3961"/>
    <dbReference type="EnsemblBacteria" id="ABF90447">
        <property type="protein sequence ID" value="ABF90447"/>
        <property type="gene ID" value="MXAN_3961"/>
    </dbReference>
    <dbReference type="GeneID" id="41361293"/>
    <dbReference type="KEGG" id="mxa:MXAN_3961"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547282_0_0_7"/>
    <dbReference type="OMA" id="RVICKSA"/>
    <dbReference type="OrthoDB" id="749484at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188386" evidence="3">
        <location>
            <begin position="36"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="498" mass="52482" checksum="409D1D2121860E29" modified="2006-07-11" version="1">MSAPGPLLPKRERTMKLLPRILFPALLLGAPLALAQDTAPHAGVTAPAASTIDISFRGTLRDALKTIADKGGLNLVVTGDLDSPAEVHLRGVTANQALRTVARAYSLRLDQDGTIFTLRPMTAQEKHAAESGESEANADAASVAPPVASDPPEMAIPPIPPIPPIPDLPNAFSEETRNEMKRARDEMKRARDEVRRNMRRNGSRNVVARGQNLEVKDGQTVESAVVYGGNLVVHGHVKDDAVAFGGNLEVHGRVDGDAHAFGGNVILGPDAHVEGDVSAFGGSVERDDDAQVEGSIESFGGAGIGRMVASEIKKGVKEAKDPSESRRDRDDDGVGLAGFILTFAMLFGLGFLGQMFFPARMKQLGEEVRRKPVQAGLTGFVGLLAMIPLTVVLCITIIGIPVALVLWMAAPVAAALGYAAVASELGTRLPIFRGRKTQAVVLALGLLVLMVVGSLPIVGPLITTLVGLMALGAVVRTRFGQRPQGMPEPVIPSSEQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5G1</accession>
    <name>Q1D5G1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_3932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553942.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3932"/>
    <dbReference type="EnsemblBacteria" id="ABF88102">
        <property type="protein sequence ID" value="ABF88102"/>
        <property type="gene ID" value="MXAN_3932"/>
    </dbReference>
    <dbReference type="GeneID" id="41361264"/>
    <dbReference type="KEGG" id="mxa:MXAN_3932"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000778_2_0_7"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="2 10" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="379"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="2277"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="10">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="10">
        <location>
            <position position="2311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF88102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="3037" mass="330332" checksum="0A7A266559AE9054" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6E0</accession>
    <name>SYFA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">MXAN_3594</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553619.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6E0"/>
    <dbReference type="SMR" id="Q1D6E0"/>
    <dbReference type="STRING" id="246197.MXAN_3594"/>
    <dbReference type="EnsemblBacteria" id="ABF92311">
        <property type="protein sequence ID" value="ABF92311"/>
        <property type="gene ID" value="MXAN_3594"/>
    </dbReference>
    <dbReference type="GeneID" id="41360940"/>
    <dbReference type="KEGG" id="mxa:MXAN_3594"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_7"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000006864" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="349" mass="38525" checksum="D2D7D0EA408A9605" modified="2006-07-11" version="1">MRDRLLALAESARREIGGASELSAVEALRVRYLGKKGELSGVLGGMGKLPPDERRSLGEVANSVKAELEKLLAEAVERAEAAALEAQLQGPGLDVTLPGRGVALGSRHPVSRTMEEIVRTFSRLGFDVASGPEIELDYFNFEALNLPKDHPARDMQDTFYVDEATLGHAKKADSSALLRTHTSPVQVRYMLNRKPPIRAVMPGRVYRRDSDITHTPMFHQVEGLLVDKGVTFAELKGSLAAFVTAFFGSDTRTRFRPSFFPFTEPSAEVDITCTNCAGKGCRICKQTGWLEVLGSGMVHPNVFTSAGYDPNEVTGYAFGMGVERIAMLRYRIDDLRMMFENDARFLEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6G3</accession>
    <name>Q1D6G3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3570"/>
    <dbReference type="EnsemblBacteria" id="ABF86986">
        <property type="protein sequence ID" value="ABF86986"/>
        <property type="gene ID" value="MXAN_3570"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3570"/>
    <dbReference type="eggNOG" id="ENOG5030X71">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570878_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="478" mass="49415" checksum="F06BAD5CEEFA22B1" modified="2006-07-11" version="1">MVRPPPALPGRVEHVQQGLLRTVEAPAPRLRQLVHGVEPGVHHLAALEHGAHGRVDMRGPRHRGGPRYSAASFTAATMVFVSTVFFTGPPVSPEGRGRTLALDPLELRLGPGCWPGTGLPGWFRVRGRAPCVRGIPPAPCEPSSRGAQGGAARQRRCRPAARPGTGQKSARRVFDGNDIRLEWGASRMSAFLDTILAFPTAIFTIVLGVVMTYWLFVIAGAVGIDLFDGDITLESGGKALSGAIEGGGKALGGAIEGGGKALGGAIEGGGKALSGAIEGGGKALGGAKALGAHDADFDVDGGGVLAAMGFAGIPITVSVSFVAFIAWLLSVVSAQPLHEALGGMMPSWLLSSGLGLACFAAGTVTAGFAVRPLRPVFVTRRAPGRDALMGRVCTISSGSVTAKTGHATFEDGGAGVILNVVCAKPNELKRGQPALILAYDAERRVYEVEPVDWLLPEEMEQLQDPARAAALARVKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6H8</accession>
    <name>Q1D6H8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ORF">MXAN_3552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553581.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3552"/>
    <dbReference type="EnsemblBacteria" id="ABF89581">
        <property type="protein sequence ID" value="ABF89581"/>
        <property type="gene ID" value="MXAN_3552"/>
    </dbReference>
    <dbReference type="GeneID" id="41360897"/>
    <dbReference type="KEGG" id="mxa:MXAN_3552"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_0_0_7"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="29892" checksum="DE8BF244D529073F" modified="2006-07-11" version="1">MAGTLYLVATPIGNLGDVTSRALETLRAVRFIACEDTRHSRVLLDHFGIGGKDLVSLPAFAEGQRAGRILDRIGEGEDCALVTDAGSPAISDPGEKLVAEALERGLTVVPVPGPTALVAALSASGLPTGRFHFLGFLPRKGAERRAMLEEVAQLSATLVLYESPRRLSETLPDLLDAWGDRRACVARELTKLHEEFARGTLSELAARYAAEEPRGEVVVLVEGRTGETRWSEEELRRALEEGLSRGEKLKALSTELARRAGWAGQDVYRLGLSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L6</accession>
    <name>Q1D6L6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3513"/>
    <dbReference type="EnsemblBacteria" id="ABF86476">
        <property type="protein sequence ID" value="ABF86476"/>
        <property type="gene ID" value="MXAN_3513"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3513"/>
    <dbReference type="eggNOG" id="ENOG5033949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249501_0_0_7"/>
    <dbReference type="OMA" id="FSSAFCY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="26174" checksum="455988FF45F628FC" modified="2006-07-11" version="1">MAPPNMTSSLSPLSYQPYLDLLIAFGSAEPRKEDLLQAKAEYFRLTGEVFEDDKLFELRMASFLDFYLYDRVSPLTNKTPATEFYEQRLAGSAPEEANAFRSFTETVHGLFEVRKLGKGEVRLRELYSGKDFDVTERRHVAGLETGDIIEARLIPFGGHLLFSSAFCYHPRMAVKAIKAEVKRRKKKEPDRTPNELVWECARRSLNMERYRQLAVEKIYDFEQKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6R0</accession>
    <name>Q1D6R0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">MXAN_3466</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553499.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3466"/>
    <dbReference type="EnsemblBacteria" id="ABF89732">
        <property type="protein sequence ID" value="ABF89732"/>
        <property type="gene ID" value="MXAN_3466"/>
    </dbReference>
    <dbReference type="GeneID" id="41360813"/>
    <dbReference type="KEGG" id="mxa:MXAN_3466"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_7"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="264"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF89732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="44939" checksum="262A965703265EFC" modified="2006-07-11" version="1">MALIVQKYGGTSVGDVARIKSVALRCLAAQEAGHDVVVVVSAMSGETNRLMKLVAQITDRPDEREQDVVVATGEQVSIGLLAMAIHAQQGKATSFLGQQVRIVTDSTFAKARIKSIDAQPIRAALARGHIVVVAGFQGVDESGSVTTLGRGGSDTTAVALAAALNADACEIYTDVDGVYTSDPNMVPSARKLDRITYEEMLELASVGAKVLQIRSVEFAMKYKVPLWVKSSFTDDPGTLVCEEDSSMEDVLVRGVAYDRNEAKITVCGVPDVAGAAAKIFGPLDEKHIVVDLIVQNPSKDGRTDVTFTVGKADFLTAQEVVRKVAEEIGASGIETDGDIAKVSIVGVGMRNHSGVAARMFRALSAEGINIQMISTSEIKVSCVVQAKYTELAVRALHTAFGLDQPMPPEGVSAVSEMAALMGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D707</accession>
    <name>Q1D707_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="ABF92444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="43" mass="4568" checksum="DE7FFA35EF51DB5C" modified="2006-07-11" version="1">MLDGGDLSATLRRFLATAGTRAVQVIELIGFFRATSALAVRTT</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
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        <source>
            <dbReference type="EMBL" id="ABF91915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="41295" checksum="5BAAD59201F05B4F" modified="2006-07-11" version="1">MTPVSEAAETPPASLSARLEEILQSHPDPAFAGRLRKVYVATAHAISRLSDLDLVRYETLVVDSSPDLSLWEEMAPVIRDTVMDVNGLLNVIREEFPVPSPGGASTQAPVGILQEAMSQIAQGITQLGEAMRNPSVMSDRWTLLAEVQRIRARFREQMSNLVFESASLLGEATRAQVVPGYAVEVKAAVTVRAITADLGRILTARLKKVREAEAQDVQWNAQQLQTEMDAFGRTAAYRNLRAQDKRHIVEMRAEVGRLAILPNPSRAELVTVVEALDTFVQGLSAVNQRQLLIIHDREVWASCGVRLERAMSLVGSDPAGAARALAEAAGSGQSLYGRATELDAFLRKARKLQVGQLSPDELRSTIVAFQGLLAGLDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
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        </location>
    </feature>
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        <location>
            <begin position="292"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="ABF91503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <sequence length="700" mass="77556" checksum="EDB01873FAF7B0EF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E7</accession>
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        <submittedName>
            <fullName evidence="9">Chain length determinant family protein</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7R7</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_399495_0_0_7"/>
    <dbReference type="OMA" id="GPYIYAR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="694" mass="72915" checksum="DB2A18D99E68F639" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7S3</accession>
    <name>Q1D7S3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3097"/>
    <dbReference type="EnsemblBacteria" id="ABF91119">
        <property type="protein sequence ID" value="ABF91119"/>
        <property type="gene ID" value="MXAN_3097"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3097"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641899_0_0_7"/>
    <dbReference type="OMA" id="HPGHSNT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043533">
        <property type="entry name" value="CNBD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="PTHR23011"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="161" mass="17392" checksum="89B4A4523A9BE946" modified="2006-07-11" version="1">MEAEAEAMLIRRSGGASAPAANGYRFLKAIPIFGELSLEDMKDLYRLARQVVIAPGAVLLEKGAPGLGLFVLMDGSVDVFSGPEEDARHLNTLGPGAYLGEISLVQDGPVSAHVRARTSVRALRISRVDFERFVDTHEAAALRIFRLFTQNLAGRVRALST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U6</accession>
    <name>RL1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">MXAN_3074</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553124.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7U6"/>
    <dbReference type="SMR" id="Q1D7U6"/>
    <dbReference type="STRING" id="246197.MXAN_3074"/>
    <dbReference type="EnsemblBacteria" id="ABF85988">
        <property type="protein sequence ID" value="ABF85988"/>
        <property type="gene ID" value="MXAN_3074"/>
    </dbReference>
    <dbReference type="GeneID" id="41360436"/>
    <dbReference type="KEGG" id="mxa:MXAN_3074"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_7"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000308058" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="237" mass="25131" checksum="E3DCD3ACC5C4A4A1" modified="2006-07-11" version="1">MAKTGKKFRAAAALVDRDKRYAVAEGFQLLKKTVEARSTKYDQTVDVSINLGVDPKHADQMVRGAVVLPHGTGATVRVAVFAKGEKATDATNAGADVVGAEDLQKRIEEGFLDFDTVIATPDMMGVVGRLGKVLGPRGLMPNPKVGTVTMDVAKAIRDAKGGKVDFRAEKAGIVHAKLGKSSFEVEKLEANFNALVDLVMKLKPAAAKGVYLQGIAISSSMGPGIKLDTMEIKTRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D833</accession>
    <name>Q1D833_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2981"/>
    <dbReference type="EnsemblBacteria" id="ABF86336">
        <property type="protein sequence ID" value="ABF86336"/>
        <property type="gene ID" value="MXAN_2981"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2981"/>
    <dbReference type="HOGENOM" id="CLU_191461_0_0_7"/>
    <dbReference type="OMA" id="MANEPKQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9729" checksum="CF32910641D7B347" modified="2006-07-11" version="1">MSAPLFLPTFQDDDDLSFRRARCRVEGGIQMANEPKQPKPEQSAPKPEERARPRTSKADEAREDGMPGYGQPDADVREQSLPEQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D873</accession>
    <name>Q1D873_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2940"/>
    <dbReference type="EnsemblBacteria" id="ABF93160">
        <property type="protein sequence ID" value="ABF93160"/>
        <property type="gene ID" value="MXAN_2940"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2940"/>
    <dbReference type="HOGENOM" id="CLU_1990245_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13848" checksum="8DD2E2F6E18F2623" modified="2006-07-11" version="1">MGGPVRSRDGEAPLVGDSRQVGRNVACLAPERVDELLHEVVTSMVRPGVFRAARTLRLDGPPVHGPGAFRRSRTLPRWPLATRRAWDRPLRGPPGQRRWKGVIVTIVSALLLIVRRECCFLANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8E4</accession>
    <name>Q1D8E4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2868"/>
    <dbReference type="EnsemblBacteria" id="ABF88334">
        <property type="protein sequence ID" value="ABF88334"/>
        <property type="gene ID" value="MXAN_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2868"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034451_1_0_7"/>
    <dbReference type="OMA" id="VWGANHD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="434" mass="48178" checksum="E1FDA16364D8CCC5" modified="2006-07-11" version="1">MGAGLFAGGAAAALGLRSALAPVSKDVQGINPRSDAWYDIRLTGDGLMDNQVLWFLSHATHGQSDVGDVLETASRIQPGDERSWFEAWTQTARRVHGHAQNAESKGHRLSAGQAYARAANYYRAATMHYTDLEDPRTLEVTRQAATTFEKSNGLLGYDVQPLAIPYEGTTLAAYFVRSPHAKPSAPVILLHQGLHAWPEETKWVWEGAARRGYHVLMFHGPGQGRSLREHRLSFRPDWEKAVSPVVDAAERISGVDPRRILLMGLSFGGALAPRAAAFEPRIALCIANPGVLSWWESTSSHFNRFLPGSLALLKSHPEQFDQAITALADRWPTAQYWLRDVYWKHGARSPSELFRKLEEFTNEAIVDRIRCPVLIMEGEAEDASPGQSQKLYDALRGPKHLMMFTHEEAAPLHCQAASTALAEARLFDWLDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8H6</accession>
    <name>Q1D8H6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aha1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552897.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2836"/>
    <dbReference type="EnsemblBacteria" id="ABF90981">
        <property type="protein sequence ID" value="ABF90981"/>
        <property type="gene ID" value="MXAN_2836"/>
    </dbReference>
    <dbReference type="GeneID" id="41360207"/>
    <dbReference type="KEGG" id="mxa:MXAN_2836"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_3_7"/>
    <dbReference type="OMA" id="FESWWGP"/>
    <dbReference type="OrthoDB" id="1914312at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17727" checksum="FA794A5BF0EF3103" modified="2006-07-11" version="1">MSNEKAKVVIERTYRAGIEDIWALWTTKEGFESWWGPQGFRAAVHELDARVGGALRYDMIADSPEMIAAMKQMGQPTSHATRSRFTEVAPHSRLVLTNVIDFLPGVAPYESKIAVDFLPSGDGVRMVVMLDAMHSEEFTKMQQEGFTSQLTKLDSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8N3</accession>
    <name>Q1D8N3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552840.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2773"/>
    <dbReference type="EnsemblBacteria" id="ABF87936">
        <property type="protein sequence ID" value="ABF87936"/>
        <property type="gene ID" value="MXAN_2773"/>
    </dbReference>
    <dbReference type="GeneID" id="41360150"/>
    <dbReference type="KEGG" id="mxa:MXAN_2773"/>
    <dbReference type="eggNOG" id="COG1222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_7"/>
    <dbReference type="OMA" id="HACHDIK"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="219"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="492"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="711" mass="77909" checksum="EC7A98F1F5AB4F6A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P0</accession>
    <name>Q1D8P0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gas vesicle protein GvpK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552833.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2766"/>
    <dbReference type="EnsemblBacteria" id="ABF88811">
        <property type="protein sequence ID" value="ABF88811"/>
        <property type="gene ID" value="MXAN_2766"/>
    </dbReference>
    <dbReference type="GeneID" id="41360143"/>
    <dbReference type="KEGG" id="mxa:MXAN_2766"/>
    <dbReference type="eggNOG" id="ENOG50330IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150705_1_0_7"/>
    <dbReference type="OMA" id="NDFARIM"/>
    <dbReference type="OrthoDB" id="2062934at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="108" mass="12072" checksum="9B15D75C97C31323" modified="2006-07-11" version="1">MAVEGAPQAVEELARALEPTKPPKLELDEENVQAGLVRLVLAVVELIRQLLERQALRRIDAGSLSEEQIERLGVTFLRLQEQMDVLKKQFDLTDEDLNLDLGPLGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P4</accession>
    <name>Q1D8P4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552829.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2762"/>
    <dbReference type="EnsemblBacteria" id="ABF91728">
        <property type="protein sequence ID" value="ABF91728"/>
        <property type="gene ID" value="MXAN_2762"/>
    </dbReference>
    <dbReference type="GeneID" id="41360139"/>
    <dbReference type="KEGG" id="mxa:MXAN_2762"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064298_0_0_7"/>
    <dbReference type="OMA" id="RINMFLR"/>
    <dbReference type="OrthoDB" id="1238363at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="32895" checksum="6429DE1024FC4D98" modified="2006-07-11" version="1">MLTSTDARARIAFDPVEFPHRYQDPRDIEVSALLAAGLAYGRADLFRPKVDALLRRMGPSPAAFVTALGVAGARALLEGFVYRFNVGTDVAVLLLGMGRVLREQGSLEALFLQGLQSRDTLHGALDHFTTGLRAIPMDALRKALGPERGLHHLLPSPLGGGAAKRLNLYLRWMVRGPDTVDFGIWKRVPPSALLIPLDTHIGRISRHLGLTFRNDLTWRTAEEVTAALRVLDPADPVRYDFALCHYGMSGACPAQPIAENCGRCPLLPACAVGPQVVATATRRVQGTTARKRRELSATRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8U4</accession>
    <name>Q1D8U4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552779.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2712"/>
    <dbReference type="EnsemblBacteria" id="ABF86535">
        <property type="protein sequence ID" value="ABF86535"/>
        <property type="gene ID" value="MXAN_2712"/>
    </dbReference>
    <dbReference type="GeneID" id="41360090"/>
    <dbReference type="KEGG" id="mxa:MXAN_2712"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_7"/>
    <dbReference type="OMA" id="TMAYTRV"/>
    <dbReference type="OrthoDB" id="1114675at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27544" checksum="021B78205E0B7B34" modified="2006-07-11" version="1">MEAGEVRYEVQGTQALLTIDRPKARNALSPAVVRELMAALERAESDTSVRVVVLTGAGEKVFCAGGDLGTLAGDEGFLSTHEGRRSYGRLLARFQELRKPTVARVNGHALAGGLGLVLACDLAVAVEGADLGTPEIDVGLFPMMMMALLQRHLGRKRALELVLTGDRLPAREALTLGLLNRVVPAAELDAAVGTLAGKLAGKSQAVLALGRRAFFTAEDLPLPAALEYLASQLSLNVLADDAGEGISAFLEKRPPKWNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y8</accession>
    <name>Q1D8Y8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="3 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pdhA</name>
        <name evidence="10" type="ORF">MXAN_2666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552736.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2666"/>
    <dbReference type="EnsemblBacteria" id="ABF90937">
        <property type="protein sequence ID" value="ABF90937"/>
        <property type="gene ID" value="MXAN_2666"/>
    </dbReference>
    <dbReference type="GeneID" id="41360042"/>
    <dbReference type="KEGG" id="mxa:MXAN_2666"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_7"/>
    <dbReference type="OMA" id="FGMPGVT"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="9">
        <location>
            <begin position="31"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="43660" checksum="C36553D1746A67ED" modified="2006-07-11" version="1">MPPREFRGRPAWRHSAVASPYSKELLLDMYRKMYLIRRFEERAGQQYTLGKIAGFCHLYIGQEAVAVGPVEALRPDDYMLSAYRDHGQPLARGSDAGMVMAELMGRDTGYSKGKGGSMHIFDIEHHFYGGYGIVGGQIPLAAGMAFASRYRNEDRVTVCYFGDAAASQGALHETFNMASKWKLPVIYICENNRYGMGTAISRIAAVPEIYKRASAYDMRGEPVDGMDVLAMYEAVKDAAEYCRAGKGPVLLEANTYRFRGHSMADPATYRTKQEVEDERKGDPIPKLRAYILKQGLAQDDVFESIEAEVNAQVDQAVKFADESPEPSLDELWRDTIVEEGEEDVRPRERVLGQKVNWPTYPSGQELKVTWDLEPREQAEAADKKAGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9A1</accession>
    <name>Q1D9A1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552623.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2553"/>
    <dbReference type="EnsemblBacteria" id="ABF92194">
        <property type="protein sequence ID" value="ABF92194"/>
        <property type="gene ID" value="MXAN_2553"/>
    </dbReference>
    <dbReference type="GeneID" id="41359931"/>
    <dbReference type="KEGG" id="mxa:MXAN_2553"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_0_7"/>
    <dbReference type="OMA" id="VWYLCAR"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="36016" checksum="ABF83E7425469059" modified="2006-07-11" version="1">MRADRLVSLTLLLQTRPKMTAGELARELEVSERTIHRDLDALSGAGVPVYATRGSAGGVALMEGWRTQLTGFTRAELHALAAVAAPGALDDLGLTSALRSGLVKMAASLPALQQPALEYARQRLHVDASSWFPEREAVPHLATLRDAVWQDRRVSLTYRDFEGKPSRKVVDPYALVIKADRWYLVASTGEDEPRVYRGSRVDGARIRPETFIRPARFDLPAFWKAWCSRFAEKRAQYEVTLRLTPEALEALRKIRPRAEGARLDSAPCSADGRKTVVVDFEREAIAFSQLCDVGSEFEVLAPEALRTKLLKLATGILDTHRSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9G3</accession>
    <name>Q1D9G3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552562.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2491"/>
    <dbReference type="EnsemblBacteria" id="ABF89419">
        <property type="protein sequence ID" value="ABF89419"/>
        <property type="gene ID" value="MXAN_2491"/>
    </dbReference>
    <dbReference type="GeneID" id="41359871"/>
    <dbReference type="KEGG" id="mxa:MXAN_2491"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501941_0_0_7"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="179" mass="19937" checksum="84C1CE635A799CBB" modified="2006-07-11" version="1">MTELPDLLSMWDVPVFAQREEVQYSPELRELGGALRPLGPEDDVRVGPETFQALHTPGSHYLLAGDALVSGDTVFINGCGRCDMSGGNPEDMYRSLSQVLAKVPDSAKLFPGHDYAGVPMASMETVRRKNPCFAFDNVDAFVAFRMRPRKDWPVPRRRCLAANGASHRRHVYPECVPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H1</accession>
    <name>Q1D9H1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PEGA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552554.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2482"/>
    <dbReference type="EnsemblBacteria" id="ABF89559">
        <property type="protein sequence ID" value="ABF89559"/>
        <property type="gene ID" value="MXAN_2482"/>
    </dbReference>
    <dbReference type="GeneID" id="41359865"/>
    <dbReference type="KEGG" id="mxa:MXAN_2482"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533930_0_0_7"/>
    <dbReference type="OMA" id="PWFWAVV"/>
    <dbReference type="OrthoDB" id="622631at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188297" description="PEGA domain-containing protein" evidence="4">
        <location>
            <begin position="35"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="5">
        <location>
            <begin position="278"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="51672" checksum="4E0841610008BE65" modified="2006-07-11" version="1">MRRSPGSASIRAVTTFRRTSLLLAFMLATSPAYGQSTRKKKSSKKPPATTQPVKTTKAPAADDADGDESVEPQAFGSPNGDEETAVTPLVSPDAPTVAKPAAAPGASGEPAVASAAVTASGPVALFAVARTSAEEDAAVKLEDELLSRLKASGVALVDLGAAFPPSPPVSLTRADTLFEQGRTDYDNLDPESAEAKFLAAAEAYTKHPAELSPERLAKAYLFLGASRMLNGDSTGALDAFKRAVVAEPSTSPDAALFGQDVLKTFDQARADVKARPAGTLVVESKPAGASVLVRGQELGVTPLKGVEMPAGQHPVVVSLPGYSAFSQYTEVASAKSTEVKATLEPTPGLSAVRDAAVHASTEQAFERDTPPPEARAIGERLNARYVVLAAVARGDKGHLQAELQAWDLRSNARLRGVEIALAPGAKKNGPDAAADQVRAFVNGVAAPRVAESNSFSTLIKRPWFWAVVGGAAAVTAGAVYVATSQDKGRPFNPVSGGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z6</accession>
    <name>Q1D9Z6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
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                <person name="Miller N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="721" mass="76954" checksum="AD4220F61D3DD93D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAL0</accession>
    <name>Q1DAL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S1C (Protease Do) subfamily</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552168.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2084"/>
    <dbReference type="EnsemblBacteria" id="ABF86165">
        <property type="protein sequence ID" value="ABF86165"/>
        <property type="gene ID" value="MXAN_2084"/>
    </dbReference>
    <dbReference type="GeneID" id="41359492"/>
    <dbReference type="KEGG" id="mxa:MXAN_2084"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_7"/>
    <dbReference type="OMA" id="QEIGRMF"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188348" evidence="2">
        <location>
            <begin position="26"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="259"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="419" mass="44237" checksum="C153EDCEA7DC7201" modified="2006-07-11" version="1">MGRARGKSVILFAALVCALVLPAQATGRERNRLWVESQNRALQKQRSTLSDVARRAMPAVVSITTQQAADVQAVAAGEEAQKGIGSGFIIHPDGYILTSAHVVEGAAEVIVSVLHPRGYVEEFEAIVVGEDARTDCALLKIAAPRKLPVLKLASASHVRSADWIVVIGNPFGLTHSVTVGVVSYMGRTDVTPNGRDGDFDYMQMDASINPGNSGGPVLDLHGDVVAVANAVNVAGQGIGFAIPIDIAKTVIPHLKSHGRVRRGWLGMSVQDFSPEVAEAFNLRRGRGVVVTDIVEGGPAERAGLQVGDVIVRVDQRSVRRAHALRWQVAARGVGRDVKFQVHRLGRPMKLTLKLDEMPSEETPLPTVASTAPGRHAGAPQPVLDDLLSPVPRSKGRRATPPSGEAAPGTGGSGQDAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAW1</accession>
    <name>Q1DAW1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552067.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1977"/>
    <dbReference type="EnsemblBacteria" id="ABF86635">
        <property type="protein sequence ID" value="ABF86635"/>
        <property type="gene ID" value="MXAN_1977"/>
    </dbReference>
    <dbReference type="GeneID" id="41359388"/>
    <dbReference type="KEGG" id="mxa:MXAN_1977"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_7"/>
    <dbReference type="OMA" id="GMCADWG"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29599" checksum="7B40C50827E8E6FE" modified="2006-07-11" version="1">MVRAGMKTQPFKGRVVLITGASGGIGRTAARAYAAAGADVVLAARRLPELEDAAREVASLGVRALPVRCDVTVGDDVTRLVRETDAAFGGLDVLVNNAGQGLYGPLEGVGEEQLRQVFELNVFSLWRMTREALPLLRKRRGAQVVNVSSVLGHRGLPLLGGYCASKAAVNAMTESLRAELAAEGIRVLLVSPGFTESDFRENRLHAEGWRQDAIPLKAMSAEEVADAMVRASRSGRRDTVLTLPGRVMVVANRWVPSLFDRVARRMALASKKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD4</accession>
    <name>Q1DBD4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551898.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1791"/>
    <dbReference type="EnsemblBacteria" id="ABF92251">
        <property type="protein sequence ID" value="ABF92251"/>
        <property type="gene ID" value="MXAN_1791"/>
    </dbReference>
    <dbReference type="GeneID" id="41359212"/>
    <dbReference type="KEGG" id="mxa:MXAN_1791"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548381_0_0_7"/>
    <dbReference type="OMA" id="GWWYPLQ"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="55514" checksum="8810DE7B358623EE" modified="2006-07-11" version="1">MRLRLTLALLAMTCSGCELIRPVVVKPPPTPSSYSTASELRTEPAQPSSAPEGGVPSPRPSKEGVPAQPAERVTQDAVWWTAFADPALDTAIQECFGDNLVLREVRELIYENQLDPNVPQGWWYPLQVGILNPAGLSHVVANANLPPAPPTRAEYNVATVGFGVTYQVDLFGALGAQRRAGLNFAEQQRQLTEGRVQDLAVRITQVWFDILEARALRDLTLRQIDYNKKLLRLIRARFEQHLTPRLVVLQQEQLLVNLESQVPLIATRNALLNSELKALLGRVPTPADDVIPLDRQLPDLPPPPKLGTPGDLNVNTPEMRLAELRVAEVEHRINANLASWLPTIQLVGNVGALKVGLSEPALAESVVGVNLTWALFDGRRVTEYMRLPIQLQRREIQYQLALHTAIGRVQDAVVREENEATSLRSLRAQVQLGQQLLDEARRLFEQGHSDYLTVLTALTNLVGLERASLQAQRLLLNHRVEVYRSLGGTWSRDVTLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE4</accession>
    <name>Q1DBE4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1781"/>
    <dbReference type="EnsemblBacteria" id="ABF86289">
        <property type="protein sequence ID" value="ABF86289"/>
        <property type="gene ID" value="MXAN_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1781"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128723_0_0_7"/>
    <dbReference type="OMA" id="AGHREIW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="44"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="179" mass="20180" checksum="E11ED9D418CC7E31" modified="2006-07-11" version="1">MRVPAPSKEAPKIHIFPKTRYARARHFRALFSSEGSMRQPTRLTVRPQTLIAVQDVKASSTWYQTLLGVRSGCEPDHPHRLVYDRLMSGDALVLQLHRWNAEEHPNLVGPDLAPHGHGVLLWFEVDEFDVAVDRARHLGAQVIEEPHVNPAPQHREIWLKDPDGYVVVLASPDGESAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ5</accession>
    <name>Q1DBJ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1727"/>
    <dbReference type="EnsemblBacteria" id="ABF91764">
        <property type="protein sequence ID" value="ABF91764"/>
        <property type="gene ID" value="MXAN_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1727"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_38_2_7"/>
    <dbReference type="OMA" id="FTHMIVE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="23383" checksum="6A64ABFABDBCFEDF" modified="2006-07-11" version="1">MPCALSETKVSHMGRKRISAAPPVASGSDTRASILSAAARAFAVDPSAPLVDVARSAGVGRATLHRYFGSREELLREAGLDSLVQLEQALKAHRFERLAPDVALESLVGALAPWGDRLRFLLVVSELSQEPSLKAIEARVDEQIMRILLRARDAGVLRQDLPSAWLFATFEALLYAAWTAVAQGDLAANDAARTIHETLLHGHGTGHLTGARKARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL0</accession>
    <name>Q1DBL0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1712"/>
    <dbReference type="EnsemblBacteria" id="ABF92518">
        <property type="protein sequence ID" value="ABF92518"/>
        <property type="gene ID" value="MXAN_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1712"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077388_0_0_7"/>
    <dbReference type="OMA" id="CGDTLWH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="102"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="33540" checksum="FD7CBDDC7D34DD77" modified="2006-07-11" version="1">MSQDALTSFSPFRMEPSNTEGRDTMARPSRTGRRDFLRAAVALSAGAVLLPPGTGRATKPVDSAALRAQRLAWAGVRLRLGQDTLFLDPLSDPTVWGAALKDPLVPVDVSDGGRFVLVTHRHSDHFDRVAVRQALGDSGTLVCAPDMAAAASASGFRVRSAPLYEPILLNDFTATAVPAADGYGDPQVSWVVSGGGRRIIHCGDTLWHGSWWHIGRQFGPFDAAFLPINGARFGWRKPVSDVHAVLTPEQAVAAALVLGAKLLVPIHYGLAASEDYQEVPDAEALLLAAARTRKVNVELARPGEWLTWRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR0</accession>
    <name>Q1DBR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551772.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1661"/>
    <dbReference type="EnsemblBacteria" id="ABF89167">
        <property type="protein sequence ID" value="ABF89167"/>
        <property type="gene ID" value="MXAN_1661"/>
    </dbReference>
    <dbReference type="GeneID" id="41359102"/>
    <dbReference type="KEGG" id="mxa:MXAN_1661"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_7"/>
    <dbReference type="OMA" id="IGRHHWR"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="20812" checksum="D4AB38AAC3353C12" modified="2006-07-11" version="1">MTPRVPFDEEALRAAVVSGDAAAREDVMRHLYEALSGKLYVLCHGITRDPSDAQDAVQETFLSIQRALPQFRGDAQLSTWAYRIAVRAAVAAKTRRERHRGDAVDIEMADPRAGIEETFETRERRRRLEVAMRTLSLEHRTVLSLFAVEGLSHAQIASVLGIPEGTAWSRLHLARKRLAAALESTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBY6</accession>
    <name>Q1DBY6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551696.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1585"/>
    <dbReference type="EnsemblBacteria" id="ABF86591">
        <property type="protein sequence ID" value="ABF86591"/>
        <property type="gene ID" value="MXAN_1585"/>
    </dbReference>
    <dbReference type="GeneID" id="41359030"/>
    <dbReference type="KEGG" id="mxa:MXAN_1585"/>
    <dbReference type="eggNOG" id="ENOG5033DC0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151908_0_0_7"/>
    <dbReference type="OMA" id="TRMRERP"/>
    <dbReference type="OrthoDB" id="2028374at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15257" checksum="5B7E5F7BC25EB853" modified="2006-07-11" version="1">MGSVIDGSIQGSGYGQRSKEGSRIARGEPGTSGIAQAGKEQAKQLGSAAKKRVYQQVESRRGDVAKGMRGLVSTLESISGREEAKVARPLLGSAAGLLRRTSDRLENETTEELLADAQTQVRERPGLFIAGCVAAGFVLGRLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC87</accession>
    <name>Q1DC87_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">MXAN_1479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551595.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1479"/>
    <dbReference type="EnsemblBacteria" id="ABF87703">
        <property type="protein sequence ID" value="ABF87703"/>
        <property type="gene ID" value="MXAN_1479"/>
    </dbReference>
    <dbReference type="GeneID" id="41358925"/>
    <dbReference type="KEGG" id="mxa:MXAN_1479"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_7"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="357"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="546" mass="59280" checksum="4B5A078BA2CC6014" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCD3</accession>
    <name>Q1DCD3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M23 peptidase domain protein</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551550.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1433"/>
    <dbReference type="EnsemblBacteria" id="ABF86920">
        <property type="protein sequence ID" value="ABF86920"/>
        <property type="gene ID" value="MXAN_1433"/>
    </dbReference>
    <dbReference type="GeneID" id="41358879"/>
    <dbReference type="KEGG" id="mxa:MXAN_1433"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920783_0_0_7"/>
    <dbReference type="OMA" id="VHLHFEL"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="202"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="34541" checksum="792CD8FF17CFBCD6" modified="2006-07-11" version="1">MRRLSILAFVSACACATRGAEPKMSFEELYATSASQSRAPDAAPAPRRVRPPAPETAPELHAVLAAFASRAQGLRQQVARGGTMPAAQVENWEQVTFALDGFLSRPAAPRVGSGDLLQAQSVLEAELERDGFTYGDMPAPLAEAVVLRVGRLALRTAELRRLEQPPEPAEDALPRFSWPVDPVSVTSLFGYRWHPVTGVHRRHLGVDLAATQGQPIYTADKGVVLRAGHNGDHGLQVEVQHEGRWVTRYSHLSRVLVDPGEVLERGNAVGLAGETGLATGVHLHFELWRDGQPMDPLEALGDAEPPPEPMPSVARGPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM3</accession>
    <name>Q1DCM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551460.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1343"/>
    <dbReference type="EnsemblBacteria" id="ABF87476">
        <property type="protein sequence ID" value="ABF87476"/>
        <property type="gene ID" value="MXAN_1343"/>
    </dbReference>
    <dbReference type="GeneID" id="41358789"/>
    <dbReference type="KEGG" id="mxa:MXAN_1343"/>
    <dbReference type="HOGENOM" id="CLU_1488194_0_0_7"/>
    <dbReference type="OMA" id="QVSYYRN"/>
    <dbReference type="OrthoDB" id="1551198at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188397" evidence="2">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="19385" checksum="8137D855147FC3BC" modified="2006-07-11" version="1">MTPAARTLAAVSLSALMAGAGLAACGLADNSLGGSVSELFPLEVSRVEVLRNAEAFQVSYYRNNDLDVDLVVRLTVSTEGLDLRPGTKVNLAGTTPSGQARATVVHLNAGEPARVFGPVNKGDLQLESGGNPGEPTRGDFSMSFSRGDGFGAGRNLEGTFSVVAQDASFGPDPGQLLDGGVPPDAGTPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCN8</accession>
    <name>Q1DCN8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551445.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1328"/>
    <dbReference type="EnsemblBacteria" id="ABF88029">
        <property type="protein sequence ID" value="ABF88029"/>
        <property type="gene ID" value="MXAN_1328"/>
    </dbReference>
    <dbReference type="GeneID" id="41358774"/>
    <dbReference type="KEGG" id="mxa:MXAN_1328"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506990_0_0_7"/>
    <dbReference type="OMA" id="CHYLPAK"/>
    <dbReference type="OrthoDB" id="265263at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188398" evidence="2">
        <location>
            <begin position="25"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="59596" checksum="08EF2B9C54C5CA01" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCP0</accession>
    <name>Q1DCP0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551443.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1326"/>
    <dbReference type="EnsemblBacteria" id="ABF88342">
        <property type="protein sequence ID" value="ABF88342"/>
        <property type="gene ID" value="MXAN_1326"/>
    </dbReference>
    <dbReference type="GeneID" id="41358772"/>
    <dbReference type="KEGG" id="mxa:MXAN_1326"/>
    <dbReference type="HOGENOM" id="CLU_1523570_0_0_7"/>
    <dbReference type="OMA" id="YERAEAQ"/>
    <dbReference type="OrthoDB" id="1540230at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="17981" checksum="48205C9576E9CEE7" modified="2006-07-11" version="1">MEGMQVRPSRASWLGVLLTAILCACGDEGGRLEGSVTSLLDLRYDRAEAQLAEGELAVSFVTQQGTGTNTVLKVSARVQDMLPEGYTGSLDVNLAEVLANGAQRGAIGRNVLDEPARTFPELRVGGLKVKALPSQQGQRISGEFHVTFVNGTHTYSGRTIFGSFEATVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS6</accession>
    <name>Q1DCS6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551407.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1290"/>
    <dbReference type="EnsemblBacteria" id="ABF89224">
        <property type="protein sequence ID" value="ABF89224"/>
        <property type="gene ID" value="MXAN_1290"/>
    </dbReference>
    <dbReference type="GeneID" id="41358736"/>
    <dbReference type="KEGG" id="mxa:MXAN_1290"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044821_0_0_7"/>
    <dbReference type="OMA" id="HGFNARI"/>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="38660" checksum="9486E5E008CA1FF8" modified="2006-07-11" version="1">MKVIRALLSSDAVTAHIRQAYSLAEPIQAQLLATGDNDSYLIESAGWRGVCRVYSLRLQPGFSHDERRCELAWLLHLAERGVRVSTPVPRRDGALLGRLDAPEGMRDLALFTWAEGESAAFSNLEGMERFGQRLAELHLASMRFQTRLPRMAIDRKRLVDTPLERITGLLQELRLEPELARLQALAEPIRRRLDSFPSDEASHGFIHGDCNGENHHLTPDGQVVFFDMDLSGPGWFAYDPAVLLWTMRRAGVPAPDIVESGARCIAGYQRVRPLASWELEALDDLVLARHFWVMGEHIVDIPSLGALRVGPSYWRLAITRILEWQQTPLVPLIRERLSREGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCX7</accession>
    <name>Q1DCX7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551356.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1237"/>
    <dbReference type="EnsemblBacteria" id="ABF90179">
        <property type="protein sequence ID" value="ABF90179"/>
        <property type="gene ID" value="MXAN_1237"/>
    </dbReference>
    <dbReference type="GeneID" id="41358686"/>
    <dbReference type="KEGG" id="mxa:MXAN_1237"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072512_0_0_7"/>
    <dbReference type="OMA" id="LAEHACH"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="28974" checksum="C76A2098BCEFABEF" modified="2006-07-11" version="1">MQPFLEPDSPRVRSAMEANQVEHMTYLARSLPGAIVKDTPGLLLVDSGLPCNTFNVVCRARLERHEADARIAAAVSHFRDKAFPFAWWVGPDAAPEDLDARLSAHGLVNAEQELGMSMDLSRLPGLALPSGLCIRRAEDEHTLTDFARVVAANWEPADPHVLDFYARTAHVALAPDSPIRFFVGYLDGEAVAASECHRAWGVAGLYSVATVRHARRRGIGAALTLAPLLDAREAGYRTATLQASAQGQGVYSRLGFVPQGTFREYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD35</accession>
    <name>Q1DD35_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trigger factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551298.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DD35"/>
    <dbReference type="STRING" id="246197.MXAN_1178"/>
    <dbReference type="EnsemblBacteria" id="ABF92137">
        <property type="protein sequence ID" value="ABF92137"/>
        <property type="gene ID" value="MXAN_1178"/>
    </dbReference>
    <dbReference type="GeneID" id="41358628"/>
    <dbReference type="KEGG" id="mxa:MXAN_1178"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760139_0_0_7"/>
    <dbReference type="OMA" id="FANNRLM"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_C" evidence="7">
        <location>
            <begin position="243"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="45100" checksum="3F4DAA091818FF49" modified="2006-07-11" version="1">MRPSPPCPASSAPSSRKRRVVNLNAPGGFGPSGALCYPRGTERETMTTHDDSQGGRKNARSLAELHALGIMKKMPAALQLDSTEPVELPTVEAPSLEGVSVAQVAPAPLTEQELVDRFDALRRQHADVRERQPGEDVALEDDALVDVLGFANNRLMPFSVRENWWVRVAADPGLPGFFESLAGAKVGQSVGIELTLPDTYPVEALRGQPARFLVSVKAARELKLLEDDSPELLSRLGMGSITDVMRKLGDELAQARLADVDRLTQERVMDVLVDRTPVELSAALVDEEIRQRWAEAERPILQRKDFQPDELQEALEGWLQDPLTRMDAAYRITLALVLRAIAERDGIQPDRAATEAMLEDLANLTGVNRQELGVAVKEDEALARRLYEMALRFSTIDHVMKKVTLTPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD68</accession>
    <name>Q1DD68_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain/tetratricopeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551265.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1145"/>
    <dbReference type="EnsemblBacteria" id="ABF88499">
        <property type="protein sequence ID" value="ABF88499"/>
        <property type="gene ID" value="MXAN_1145"/>
    </dbReference>
    <dbReference type="GeneID" id="41358596"/>
    <dbReference type="KEGG" id="mxa:MXAN_1145"/>
    <dbReference type="eggNOG" id="COG4235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527585_0_0_7"/>
    <dbReference type="OMA" id="RYLMKPE"/>
    <dbReference type="OrthoDB" id="229043at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DUF4388" evidence="3">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="57651" checksum="8F81ABA9077D2CDE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD99</accession>
    <name>Q1DD99_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551234.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1114"/>
    <dbReference type="EnsemblBacteria" id="ABF91156">
        <property type="protein sequence ID" value="ABF91156"/>
        <property type="gene ID" value="MXAN_1114"/>
    </dbReference>
    <dbReference type="GeneID" id="41358566"/>
    <dbReference type="KEGG" id="mxa:MXAN_1114"/>
    <dbReference type="eggNOG" id="COG5031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083028_0_0_7"/>
    <dbReference type="OMA" id="DIWHVLT"/>
    <dbReference type="OrthoDB" id="738359at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="PTHR12922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30862" checksum="73E3691B6E62C10B" modified="2006-07-11" version="1">MSAPRPSGCPPASTAAVPPPRPCASHIRWTGRPQRPRLGGTMWNPVANARAAWRMARALRDPEKLQDVLGLAPVLAPPVAMRRLVERLMSHASAAQAFIERPRVGLLHLAALRALPEHTLGRAFVDHLEANQVNPDALPYLEARTDEEYVRAHLLESHDVWHVLTGFPTSVAGELGIQAFSLAQVGSPFALGILAGGLTNTLLYAFSQREERMRAIVRGWLLGQRARPLFGAPWCQMWESPLAEVRQRYGLDLAAVDAVLDDPMRPAMEVRNPGSASPPQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDA0</accession>
    <name>Q1DDA0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase, beta subunit</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pccB</name>
        <name evidence="3" type="ORF">MXAN_1113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551233.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1113"/>
    <dbReference type="EnsemblBacteria" id="ABF88262">
        <property type="protein sequence ID" value="ABF88262"/>
        <property type="gene ID" value="MXAN_1113"/>
    </dbReference>
    <dbReference type="GeneID" id="41358565"/>
    <dbReference type="KEGG" id="mxa:MXAN_1113"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_7"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="267"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="520" mass="56561" checksum="BDCCCE73CAE5E9E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE63</accession>
    <name>Q1DE63_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_0797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550920.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0797"/>
    <dbReference type="EnsemblBacteria" id="ABF92852">
        <property type="protein sequence ID" value="ABF92852"/>
        <property type="gene ID" value="MXAN_0797"/>
    </dbReference>
    <dbReference type="GeneID" id="41358263"/>
    <dbReference type="KEGG" id="mxa:MXAN_0797"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_2_7"/>
    <dbReference type="OMA" id="CMFHMMN"/>
    <dbReference type="OrthoDB" id="357522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="9">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="45"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="167"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="287"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="10">
        <location>
            <begin position="471"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF92852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="602" mass="65443" checksum="36933790B5CBE5C8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB6</accession>
    <name>Q1DEB6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550867.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0741"/>
    <dbReference type="EnsemblBacteria" id="ABF86267">
        <property type="protein sequence ID" value="ABF86267"/>
        <property type="gene ID" value="MXAN_0741"/>
    </dbReference>
    <dbReference type="GeneID" id="41358212"/>
    <dbReference type="KEGG" id="mxa:MXAN_0741"/>
    <dbReference type="HOGENOM" id="CLU_095298_0_0_7"/>
    <dbReference type="OMA" id="DGHRGIT"/>
    <dbReference type="OrthoDB" id="1226282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188439" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="27312" checksum="A8F06049CDAF77B2" modified="2006-07-11" version="1">MTWRRGLLVTACLLGAAPVVAQGTAAKAPAASPAQPEASARPRFAWPRVQVIDTVESNEIVEAGGIPVALRAVHAKERMDDLVQRFADAFIQAGLHLPPGHEQPQLASGAVMLTAIDGHRGITYTVIFQPQPDRTTLMYLGEANHALRRDPAAAGDFAPMPPQASQVLRVNSESSRTLAFHVPLSGEAVDAFYAQALTRAGWRLEEGETSFYVRTGEELRVVHEPGEGNQRAVVLVYRGGRSVPPPPPGPAAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF42</accession>
    <name>Q1DF42_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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    <sequence length="242" mass="26317" checksum="760F666CADF9A2B0" modified="2006-07-11" version="1">MAGRDLQARERAAVADVVASTLRHDLRNKLASIRNASFYLMRQVKKTDLWSADPRVETFFQLIEKELTSAEDVLSKRAPPPTGGTRPRCSAREGVERALAEAQVPPSVEVVRDLKEQGGVPLEVEDLALLVRCLVDNALEAMPRGGTLTVRTRDAESGVCLRVEDTGEGLAAEAYSRALEPFFTTRPHHAGLGLSIVHRTAVRHGWQLDLGAGPSGGTYVEIQFTGLEAGAHDRNDVTRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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    <sequence length="215" mass="23534" checksum="F115094758542F05" modified="2006-07-11" version="1">MRHTRGITLLEMMVTVAIASILLAAALMGIQTPVNRQRENEATRELWASTLRARQRAISTNQPVRIVVEENVPRGDGTSRTVARWEQLRCDNEWDNAGCPANGCENTTCRTNPACCSEVGQDIVIPVSMNAFAIHGLCYMPGSGRPVRPGDLTCMRDFLDDLPALDAAAPGNLRFDFTSGRPRSLIQVEPRTGLANVMDCNPHASTQNQAIECVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM7</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN0</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="284" mass="30717" checksum="9ED5DDC0CAA7BAC4" modified="2006-07-11" version="1">MPLHPNPPGAPVRGFERCVCSPPGGACPTLQSPMTNAELSARLLSNVIAFKHLQRERGTLRHLGLPGVDAFCLPGHPEHSRAQQAFFHDPGALRDALPALTDFYLRLDLPGWRVVLPPGDTEGRRVLEDAGFAPDAVRMDAMGLVLGDVPDAPPDLPLEVSETQDDMVAINKRTWGELGGQLDVWLRPPPLPVHTLVAKEVGVALACGMARDVGDTAGIYMVATVPEARGRGLAAQVMRGLHHQARARRMTAAVLQATPEAKPLYQRLGYRDLGAWETWGRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS3</accession>
    <name>Q1DFS3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90402">
        <property type="protein sequence ID" value="ABF90402"/>
        <property type="gene ID" value="MXAN_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0218"/>
    <dbReference type="HOGENOM" id="CLU_469148_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="581" mass="61907" checksum="C0BAE88A1D6F1E22" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG24</accession>
    <name>Q1DG24_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550263.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0116"/>
    <dbReference type="EnsemblBacteria" id="ABF87993">
        <property type="protein sequence ID" value="ABF87993"/>
        <property type="gene ID" value="MXAN_0116"/>
    </dbReference>
    <dbReference type="GeneID" id="41357621"/>
    <dbReference type="KEGG" id="mxa:MXAN_0116"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="ERCEGNI"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="138"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="49564" checksum="B8724511D59FCFF7" modified="2006-07-11" version="1">MAPSNEEDPALDPTLTLSRARQGRVRLKLMVLSGPESGQSHALTRPEYVLGKAPTCDIVLTDKTISREHLKLTVHDEHVVATDMGSRNGSSCDGRRFTELELHPGTVITLGTTELKLVPEESAKRTLLLSNRDRFGALVGNSRRMREVFTLLERLSPGGADVLIQGETGTGKDLCAEAIHQASRRASGPFVIVDLAGVAPSLIESELFGHVKGAFTNAQSDRAGAFERAHNGTVFLDEVGELPLELQPRLLRVLERRQVKRVGANDYVTVNMRVVTATHRDLEDAVRQGKFRRDLYHRLAVLRVTMPSLRERPEDIPLLIDTMLEQTGRPPSTLSDQTRALLTQYPWPGNVRELRNVVEQVVNLGEEALPELEPADSERGHSAADLDLPFKEAKERLVEGFERDYLRNLLERCEGNISRASREADIDRVYLRKLLKKHGIEPSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVT4</accession>
    <name>Q1CVT4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557294.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7382"/>
    <dbReference type="EnsemblBacteria" id="ABF89946">
        <property type="protein sequence ID" value="ABF89946"/>
        <property type="gene ID" value="MXAN_7382"/>
    </dbReference>
    <dbReference type="GeneID" id="41364541"/>
    <dbReference type="KEGG" id="mxa:MXAN_7382"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1413834_0_0_7"/>
    <dbReference type="OMA" id="RDAHMLE"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187826" description="YceI domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="20820" checksum="63DCC58982E8613D" modified="2006-07-11" version="1">MIARRIALIATLVLALPAVAQSQARTYSVKKDASSLTYKLKHKLHEVVGKAQPSDGKARLLPDGTLQVAVRANVKDFDSGNANRDAHMLETTDAARFPIIDFKGVATGVKPPTSFPAKVPVKVKGQLTFHGVKKTVEIPMTVLFKSEKQAVAEGSFDISLDAYNVNRPSLLMVKVDDVLVLEPKLVFEVEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV3</accession>
    <name>Q1CVV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557275.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7362"/>
    <dbReference type="EnsemblBacteria" id="ABF91599">
        <property type="protein sequence ID" value="ABF91599"/>
        <property type="gene ID" value="MXAN_7362"/>
    </dbReference>
    <dbReference type="GeneID" id="41364523"/>
    <dbReference type="KEGG" id="mxa:MXAN_7362"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_7"/>
    <dbReference type="OMA" id="PSGFDLC"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
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    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="260"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="386"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="542"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="673" mass="72590" checksum="38CB3294F628C3C3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW29</accession>
    <name>Q1CW29_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Crm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crm2</name>
        <name evidence="2" type="ORF">MXAN_7281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7281"/>
    <dbReference type="EnsemblBacteria" id="ABF86748">
        <property type="protein sequence ID" value="ABF86748"/>
        <property type="gene ID" value="MXAN_7281"/>
    </dbReference>
    <dbReference type="GeneID" id="41364446"/>
    <dbReference type="KEGG" id="mxa:MXAN_7281"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012640_1_0_7"/>
    <dbReference type="OMA" id="EFYAAWV"/>
    <dbReference type="OrthoDB" id="1599626at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
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    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
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    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013407">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040942">
        <property type="entry name" value="Minimal_Cpol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18182">
        <property type="entry name" value="mCpol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02577">
        <property type="entry name" value="cas_TM1794_Cmr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="318"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="64981" checksum="9CDFE187E3C279AC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW83</accession>
    <name>Q1CW83_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557146.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7227"/>
    <dbReference type="EnsemblBacteria" id="ABF87472">
        <property type="protein sequence ID" value="ABF87472"/>
        <property type="gene ID" value="MXAN_7227"/>
    </dbReference>
    <dbReference type="GeneID" id="41364396"/>
    <dbReference type="KEGG" id="mxa:MXAN_7227"/>
    <dbReference type="eggNOG" id="ENOG5032THN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260314_0_0_7"/>
    <dbReference type="OMA" id="WAWERPE"/>
    <dbReference type="OrthoDB" id="1419030at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021488">
        <property type="entry name" value="DUF3142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11340">
        <property type="entry name" value="DUF3142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="28441" checksum="7DE7BED741A209F8" modified="2006-07-11" version="1">MLLPSPSPLVAPRTRRGLLATLAVLMSCSTPTPPPEPPRVVLWAWERPEDLRFLARTGRPVSVAFLRATLALTETEVREHPRRQPLHVPPGTPLRATVRMEAHPGASLARYPPERLHALADRLATLARLPELTALQIDFDARASEYDAYVALLQALRQKLPPSMALSITGLASWCTPGSWLTHAPVDEVVPQLFRMGPEAPTWRARFARGLPAPCRGSVGLALDEWQAVPPGVSTLYVFNPRPWTPEAFTRAVAELHP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX51</accession>
    <name>G6PI_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="ordered locus">MXAN_6908</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CX51"/>
    <dbReference type="SMR" id="Q1CX51"/>
    <dbReference type="STRING" id="246197.MXAN_6908"/>
    <dbReference type="EnsemblBacteria" id="ABF87421">
        <property type="protein sequence ID" value="ABF87421"/>
        <property type="gene ID" value="MXAN_6908"/>
    </dbReference>
    <dbReference type="GeneID" id="41364090"/>
    <dbReference type="KEGG" id="mxa:MXAN_6908"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033288_0_0_7"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
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    <dbReference type="UniPathway" id="UPA00138"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="SIS_PGI_2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="G6PISOMERASE"/>
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    </dbReference>
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    <keyword id="KW-0963">Cytoplasm</keyword>
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    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000252631" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="529" mass="58323" checksum="26510B9D51A9DD5A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX65</accession>
    <name>Q1CX65_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6894</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89857.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="39151" checksum="FD9ADB7A46AC3084" modified="2006-07-11" version="1">MRHAECLMNGSDPAGLGSPPLVLSFRHLLTDAVSTFLDEASMSCELTADAIGELIVTLSRYREEGAPLFPMAFVGDDLGQMLEHLGGHDPIAIGIGPRSRATIQRALKQCAPLGQGRWWALYLLRVPEGFAYGVFRTDPFPLAETPLERLRRVEDRGAGVVGVLQLADNILELRSGGGLCRHVYLSGARVESASPPEVMDELADVVTAGVTTHSRERARGFFRRVLFEVMQGSHGALVAVLPRERAGSTLFVDGIILPRPLDIVALLERYHVDPTDSAGTAVRAAAQLLRGMMATDGITVLRADGCIVGYNIFVRHPETLASQPSVVGGARRRTFEVLCAALGTELTAAFIRSQDGDVSCKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX91</accession>
    <name>Q1CX91_MYXXD</name>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
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        </recommendedName>
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        <name evidence="7" type="ORF">MXAN_6865</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
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    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="353"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="418"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="68335" checksum="B0F6F173CC5E0EB0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC1</accession>
    <name>Q1CXC1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative deoxyribonuclease I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556760.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6835"/>
    <dbReference type="EnsemblBacteria" id="ABF88112">
        <property type="protein sequence ID" value="ABF88112"/>
        <property type="gene ID" value="MXAN_6835"/>
    </dbReference>
    <dbReference type="GeneID" id="41364024"/>
    <dbReference type="KEGG" id="mxa:MXAN_6835"/>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969188_0_0_7"/>
    <dbReference type="OMA" id="DHNMACT"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="32147" checksum="E229676D2B421499" modified="2006-07-11" version="1">MGFPSFLLRVVVLAVLAVPTWAQAGSYLRVVSWNLRHEGWTAEQTYREDAEQIWRQYGANSNSNNGCDLVFLQEVMNASVVPAIVAELNAVSGVKWRYAQTPLIGRSSYKEIYAVLYREDTVSLLSSSVYEDTGDTFEREPQIVRVRHTPTGADYTFINWHTVWGNPSDRDAEVKQIGAVFKSVQDASRTDQDVILVGDHNMACTTASWANLVALSPTVECKLNVATTINLSGGYVNAYDHFWMQPEYVTEFSSAGRDYIGNTRDFVTRLADHAPIYLTLYSTSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL5</accession>
    <name>Q1CXL5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Albicidin resistance domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556666.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6741"/>
    <dbReference type="EnsemblBacteria" id="ABF90105">
        <property type="protein sequence ID" value="ABF90105"/>
        <property type="gene ID" value="MXAN_6741"/>
    </dbReference>
    <dbReference type="GeneID" id="41363933"/>
    <dbReference type="KEGG" id="mxa:MXAN_6741"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2106328_0_0_7"/>
    <dbReference type="OMA" id="NATHQQE"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TipAS" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="115" mass="12883" checksum="CE9614738CB13E1C" modified="2006-07-11" version="1">MFEKHYTPEQLQQLKARREALGEEAIRQVEAEWPQLIARVRAEMDQGTDPTSEPVRSLAMRWRELLKAFTGGDPGIEGALNATHQQEPEVAVKHGLDPALFAYIGKAMASLEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXR4</accession>
    <name>Q1CXR4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">difE</name>
        <name evidence="13" type="ORF">MXAN_6692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2012627">
            <id>Q1CXR4</id>
        </interactant>
        <interactant intactId="EBI-2012616">
            <id>Q1CXR2</id>
            <label>difC</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-2012627">
            <id>Q1CXR4</id>
        </interactant>
        <interactant intactId="EBI-2012704">
            <id>Q1CXR3</id>
            <label>difD</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556617.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CXR4">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6692"/>
    <dbReference type="EnsemblBacteria" id="ABF92648">
        <property type="protein sequence ID" value="ABF92648"/>
        <property type="gene ID" value="MXAN_6692"/>
    </dbReference>
    <dbReference type="GeneID" id="41363885"/>
    <dbReference type="KEGG" id="mxa:MXAN_6692"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_7_7"/>
    <dbReference type="OMA" id="KGMASSM"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037052">
        <property type="entry name" value="CheA-like_P2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="12">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="522"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="11">
        <location>
            <begin position="727"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF92648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="857" mass="86784" checksum="0CA94314DD5AF420" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXU6</accession>
    <name>Q1CXU6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556585.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6660"/>
    <dbReference type="EnsemblBacteria" id="ABF92597">
        <property type="protein sequence ID" value="ABF92597"/>
        <property type="gene ID" value="MXAN_6660"/>
    </dbReference>
    <dbReference type="GeneID" id="41363858"/>
    <dbReference type="KEGG" id="mxa:MXAN_6660"/>
    <dbReference type="eggNOG" id="ENOG5033ACE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072476_0_0_7"/>
    <dbReference type="OMA" id="STADYPE"/>
    <dbReference type="OrthoDB" id="1499889at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187890" evidence="2">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="25336" checksum="68EF4E122882E5E7" modified="2006-07-11" version="1">MPMSPLSRLVASLATLSLIAAACAGQQKPDNREASSTIEEVANEGGEETPTVAFNVLDAPEGFTVKLPGPPPQAQRSEAALPKRTDKATLVTYAANEGGVSYIVNAVDYPEAFVATVPAEALINGGIQGIAGQVGGELKSSEDITLDGYPGKAYMLASPSGEVKGRSFLVGPRVYNLITVYNAGIGAPGADEFLTSLTLVNPPPKIEIPEADAGTDAGTAGAADGTAAAVEGGEDAGSAPDAGARRRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX2</accession>
    <name>Q1CXX2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556559.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6634"/>
    <dbReference type="EnsemblBacteria" id="ABF91179">
        <property type="protein sequence ID" value="ABF91179"/>
        <property type="gene ID" value="MXAN_6634"/>
    </dbReference>
    <dbReference type="GeneID" id="41363831"/>
    <dbReference type="KEGG" id="mxa:MXAN_6634"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_1_1_7"/>
    <dbReference type="OMA" id="DPIYSDR"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="183"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="46615" checksum="3542761EC6872D5B" modified="2006-07-11" version="1">MSGGLRGAEALAFSSARRRCVTPAVQWRPQTGVAGCRTGANPVHCRAETWTSSPGRAGVFPVLSEWSTAPMSLDRSSRPMTKLLSLVLLLSAPWLGGCLFAGPRHQGPVTEHFDGEQFQNLEPINRLSPEEVFKALRKGPRGPWRDYEEFAPGKPPPERVGPGQLRVTFINHATVLVQADGLNMLTDPIYSDRPSPVPFIGPRRVRPPGIRFEDLPPIDVVVVSHNHYDHMDLPTLRRLEEAHHPRFIVGLGNKALLDGEGFRHVVELDWWKSTEVAPGRTVTAVPAQHRSNRGLTDSAATLWAGYVLATSGGPVFFAGDTGFGPHFAMMAERFGPMRLSVLPIGAYRPTAFRPVHMGPVEALQAHKVLRSATSVAMHYGTFALALDGQDEAKYHLLWLLAREPVRPRFWALGFGEGRDVPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ2</accession>
    <name>Q1CXZ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556539.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6613"/>
    <dbReference type="TCDB" id="9.B.139.2.1">
        <property type="family name" value="the pmf-dissipating cannabalism toxin sdpc (sdpc) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93151">
        <property type="protein sequence ID" value="ABF93151"/>
        <property type="gene ID" value="MXAN_6613"/>
    </dbReference>
    <dbReference type="GeneID" id="41363811"/>
    <dbReference type="KEGG" id="mxa:MXAN_6613"/>
    <dbReference type="eggNOG" id="ENOG5033NKB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303812_0_0_7"/>
    <dbReference type="OMA" id="TIFITQI"/>
    <dbReference type="OrthoDB" id="2136278at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023888">
        <property type="entry name" value="Antimicrobial_SdpC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04032">
        <property type="entry name" value="toxin_SdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="22551" checksum="7A181F7615086FC7" modified="2006-07-11" version="1">MKRSTLKLTSAVTAFMTFSTFGIGCGPADGSSGPSAGITQNQALSGQNLFKGMAFGLGPAAHYFDDLWQRPEIKAKLGDETLAKREEAAEAVIAKMSALDPAFFERFGNDLRSGNHLVIDQLLTDTRELTVAAANALRKDAGQAGEINAAALQQVEAGLYLYVETAVAVAIVLILILTQIDMTPVMEGPQSSQLQRDVWVDMLAKRFAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY59</accession>
    <name>Q1CY59_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPFH/band 7 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556472.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6542"/>
    <dbReference type="EnsemblBacteria" id="ABF86662">
        <property type="protein sequence ID" value="ABF86662"/>
        <property type="gene ID" value="MXAN_6542"/>
    </dbReference>
    <dbReference type="GeneID" id="41363747"/>
    <dbReference type="KEGG" id="mxa:MXAN_6542"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069124_0_0_7"/>
    <dbReference type="OMA" id="ATVTYRI"/>
    <dbReference type="OrthoDB" id="1564719at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="333" mass="36652" checksum="19C724425BCDC786" modified="2006-07-11" version="1">MCLEDTKRGGGPMVIGYMKAAPTTYVMQFEAGKVVREGAGLSFFYWKPSATLVSVPLSSADVPFVFNEVTRDFQAVTLQGQLTWRVTDPRRLASLLDYSLGPTGRYHSDDPEKLEERLVQVAQVRARSVVQGLTLREVLVRSDAIEQQVLAALAVAEPVKALGVEVMAFSLLSVKPAPEMARALEAEAREALQRNADEAIYARRNAAVEQERRIKESELATELAVEARQRQIREAKMAADIAVEEQRAELMTRWSDNERQAADARAYALEKTLAPVRGVDWKTLMATSASGGDPALNIALAFREMAENAQRIGELNVSPDLLHSLVGAAGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF4</accession>
    <name>Q1CYF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556377.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6445"/>
    <dbReference type="EnsemblBacteria" id="ABF89822">
        <property type="protein sequence ID" value="ABF89822"/>
        <property type="gene ID" value="MXAN_6445"/>
    </dbReference>
    <dbReference type="GeneID" id="41363654"/>
    <dbReference type="KEGG" id="mxa:MXAN_6445"/>
    <dbReference type="HOGENOM" id="CLU_2115891_0_0_7"/>
    <dbReference type="OMA" id="PYWLLIS"/>
    <dbReference type="OrthoDB" id="1756794at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="112" mass="12326" checksum="031C0540F4EC7C1F" modified="2006-07-11" version="1">MSTDQAPPYWLLISVLFSNQPLSPSLAMTLHQVAYELHQRGEGAKEVAGDMVSGRVVNLRKDVSFGGIAGPAFEAEIETERGSGVVRFVLTRQGLEMMKQQPAEPPRPKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYH3</accession>
    <name>Q1CYH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556358.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6426"/>
    <dbReference type="EnsemblBacteria" id="ABF88077">
        <property type="protein sequence ID" value="ABF88077"/>
        <property type="gene ID" value="MXAN_6426"/>
    </dbReference>
    <dbReference type="GeneID" id="41363636"/>
    <dbReference type="KEGG" id="mxa:MXAN_6426"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="NLRTAGD"/>
    <dbReference type="OrthoDB" id="1068772at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="164"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="540" mass="58529" checksum="F31E5995BA3F080B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYL6</accession>
    <name>Q1CYL6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556315.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6383"/>
    <dbReference type="EnsemblBacteria" id="ABF90018">
        <property type="protein sequence ID" value="ABF90018"/>
        <property type="gene ID" value="MXAN_6383"/>
    </dbReference>
    <dbReference type="GeneID" id="41363594"/>
    <dbReference type="KEGG" id="mxa:MXAN_6383"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_5_3_7"/>
    <dbReference type="OMA" id="DIFPRVP"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="184"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="46167" checksum="A4FFF7DE2668991C" modified="2006-07-11" version="1">MSPAPAMTVPLHAKGAPSMGRLLFLLVFNVSAWAVLRSLWPGLLRKWRLGAFALGTFLSLVAWLYSAVAGRHAQLPVGDAALRVFSVGWSVAIIMIVLAGAPFLLLRRWLDRPARQEPPLTAPEANPAPPVNMARRNLLTNAGRAVPLLAAGTSSVGLANGYTQFSVREVDIHLPGLSPAMDGFRIGQITDVHVGTFIDTQYLQDAVRAMNDAKVDLQVMTGDLIDDLDQLDGTMAALSECKARHGMLAILGNHEHWRGLEAIRQAYADVEARGGPVRLLVDTSHAFEHAGQRVRVVGVDYPMSGRSHRVKAERMQQSAEAGFRDVAPEEVVLCLTHHPDFFPLAAERGARLTLAGHTHGGQVAFLGVPALWFVFKYMLGRYRQGDHQLYVSGGTGHWLPFRIGVPTEVTVLTLRATGASAAGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYS1</accession>
    <name>Q1CYS1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556260.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6327"/>
    <dbReference type="EnsemblBacteria" id="ABF88030">
        <property type="protein sequence ID" value="ABF88030"/>
        <property type="gene ID" value="MXAN_6327"/>
    </dbReference>
    <dbReference type="GeneID" id="41363543"/>
    <dbReference type="KEGG" id="mxa:MXAN_6327"/>
    <dbReference type="HOGENOM" id="CLU_1260324_0_0_7"/>
    <dbReference type="OMA" id="ATDALWK"/>
    <dbReference type="OrthoDB" id="1391134at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="24180" checksum="7936305C06C19458" modified="2006-07-11" version="1">MSSPEAPARGGTLGPMAHLSRVLTVVLGAALGALGAWVLMKPASPSLPDTPSVVQQMRDVARLETLEVSLYKKVTFTPEPQATDALWKDVLNWARYALQNPHGRAIVFANAHLGFDFQRFDRSHLQVTGTRVYVMLPPMEVKVELRPGETEVIDSNLDSEQTAQLLEKARLAFEQEVRSNGKLQRRARESAERSLRALLLTLGYREVLFVDHLPAGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYW4</accession>
    <name>Q1CYW4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6282"/>
    <dbReference type="EnsemblBacteria" id="ABF87129">
        <property type="protein sequence ID" value="ABF87129"/>
        <property type="gene ID" value="MXAN_6282"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6282"/>
    <dbReference type="HOGENOM" id="CLU_140315_0_0_7"/>
    <dbReference type="OMA" id="SAMGPNC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="17479" checksum="93BE95F627FC8171" modified="2006-07-11" version="1">MQLGSIRVLRLWVWLVFVVGWWVWTGRVHMATPSSGVSISEEERTTMKKLLLGFMLAVVPAVGCGVGADDAPTDTVETVTTESGESINLDYSPLTSEEEPLASMGDADGEVSAMGPNCWVTLLYCKDPRYNDWATCKQNGKCTTKQFVDNCLALYKKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYY6</accession>
    <name>Q1CYY6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6258"/>
    <dbReference type="EnsemblBacteria" id="ABF87972">
        <property type="protein sequence ID" value="ABF87972"/>
        <property type="gene ID" value="MXAN_6258"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6258"/>
    <dbReference type="HOGENOM" id="CLU_116685_0_0_7"/>
    <dbReference type="OMA" id="GRWNILP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="22215" checksum="472BC619EACA938E" modified="2006-07-11" version="1">MPFLAPGSTLSAGGRERMNRRLASFFRRDPAEVQGAYFLLKGLLPWLQPKRVTRFTGPIREGWLMKTVGGLAGTVGATLLSAHRHGRVTPELRKLGIWSALTLLVVDVSTYTTNRKRRSPVFLADAAIQAALLAAQWRARSRMPVVIDARASSLRDPSRYGAGEHGRWNILPGESRDAAGNRDIVDEGSMSSFPASDPPSYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ48</accession>
    <name>Q1CZ48_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556138.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6194"/>
    <dbReference type="EnsemblBacteria" id="ABF86528">
        <property type="protein sequence ID" value="ABF86528"/>
        <property type="gene ID" value="MXAN_6194"/>
    </dbReference>
    <dbReference type="GeneID" id="41363423"/>
    <dbReference type="KEGG" id="mxa:MXAN_6194"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_1_7"/>
    <dbReference type="OMA" id="EIVLCNA"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023842">
        <property type="entry name" value="Bacillithiol_biosynth_BshB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04001">
        <property type="entry name" value="thiol_BshB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="29483" checksum="64196E060735DF3F" modified="2006-07-11" version="1">MSANGTAYGIDVLAFGPHPDDVELFCGGLLASMAARGYRTGIVDLTRGEKSSRGTLQSRAEETEAATRALGLAHRENLELPDGWLNPWAGFDTPEPERARTAAVARVVEALRRLRPELVVVPWEQERHPDHEAASALVTRALFFAGVRKFDAEPAAEPFTPRQVLYYPMRHLTEPSVIVDVSAVYERKLAAVHCYASQVLPRPDAPPTLVGSPLSVSSLEARDRFHGAQIGVTHGEPYILREALGLADPLDHFRRNSFAKPLFFPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ82</accession>
    <name>Q1CZ82_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homocysteine S-methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556104.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6160"/>
    <dbReference type="EnsemblBacteria" id="ABF87652">
        <property type="protein sequence ID" value="ABF87652"/>
        <property type="gene ID" value="MXAN_6160"/>
    </dbReference>
    <dbReference type="GeneID" id="41363390"/>
    <dbReference type="KEGG" id="mxa:MXAN_6160"/>
    <dbReference type="eggNOG" id="COG2040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062282_0_0_7"/>
    <dbReference type="OMA" id="CCGTDHR"/>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="34484" checksum="05ADF8703441DB38" modified="2006-07-11" version="1">MGGLANHAAFLHALHNAPRMLTEGSVVERLRRHPAGLLDPHVANASLLLEPEGREALAAIYRDYRDIGLRHGLPTLLLTPTWRANAERLARAGLAGRDVFTEAVRLLAGLRDELGERETRVFVGGLVGCRGDAYQPAEALPRREAAAFHAPHVEALSRAGVDFLVAQALPALSEAEGLALAMARTGAPFLLSFVLRPTGTLLDGTPLAEAVARIDALPDARPTAYMVNCVHPSVFREGLSHQLAASPSLGARVVGLQANTSRLSPEELDGRAELDCAPPDAFAREMARVHAELGTRVLGGCCGTDERHIAALAGILTEGTPGALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZD1</accession>
    <name>Q1CZD1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556056.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6107"/>
    <dbReference type="EnsemblBacteria" id="ABF90210">
        <property type="protein sequence ID" value="ABF90210"/>
        <property type="gene ID" value="MXAN_6107"/>
    </dbReference>
    <dbReference type="GeneID" id="41363341"/>
    <dbReference type="KEGG" id="mxa:MXAN_6107"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_7"/>
    <dbReference type="OMA" id="FWGEFAR"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="34147" checksum="EC08BB6F2F945F3D" modified="2006-07-11" version="1">MRALQLQRLDGPDGLQLVDVPEPEAGDSVLIDVVAAGVSFPDLLLTRGQYQLKPALPFIPGVEVAGVVRQAPAGAGVKPGQRVMAFSFGLGGFAEVAAIQPEMVFPIPADWSFEAAAGVVMNYHTAHFALHRRGRLKAEESVVVHGAAGGVGTAAVQVARGAKARVIAVVSDERKADVARRAGAHEVLLSTGDWVAQVREKTGGLGANVVVDPVGGDIFDKSLKCLAPEGRLLVVGFASGRIPEVQVNRLLLRNIDVVGVAWGGFLLHEPSLTPTIAKDLEAMADRGVLTPVVGPVFPLEQGAQALRELDARRATGKVVLRMREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZM5</accession>
    <name>Q1CZM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6013"/>
    <dbReference type="EnsemblBacteria" id="ABF90243">
        <property type="protein sequence ID" value="ABF90243"/>
        <property type="gene ID" value="MXAN_6013"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6013"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058222_0_0_7"/>
    <dbReference type="OMA" id="FIATDKP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29696" checksum="FEA50C4A6F8D486B" modified="2006-07-11" version="1">MQSLPAHEVFGLKPTASLDELRLAYFRMARRFTPDHVSPDTHPELKKVSAEIFDFLSRRMRDAEANWTQAAQAPRPPPPVVPAAPPRPPPVVHAAPAAVRAPVVPAAPPPRPVQAAPVMARAPIAPPPAPPPPAPPPPAPAMRRAAAAPTYSSAEFVGLERRSDDRIHADVKVTLQNAGIFTDHRIINLSSGGLFIATDKPLRLGTLVELTLRFDEPPRVLTLRSSVIWENSLEDGKNPRGYGLRLSHLRPEEKEFVQKYLARAKDLKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D000</accession>
    <name>Q1D000_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555837.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5886"/>
    <dbReference type="EnsemblBacteria" id="ABF91123">
        <property type="protein sequence ID" value="ABF91123"/>
        <property type="gene ID" value="MXAN_5886"/>
    </dbReference>
    <dbReference type="GeneID" id="41363125"/>
    <dbReference type="KEGG" id="mxa:MXAN_5886"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271462_0_0_7"/>
    <dbReference type="OMA" id="RFITMEV"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130684" checksum="51171601A6411149" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D006</accession>
    <name>Q1D006_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555831.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5880"/>
    <dbReference type="TCDB" id="9.B.104.6.1">
        <property type="family name" value="the rhomboid protease (rhomboid) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92940">
        <property type="protein sequence ID" value="ABF92940"/>
        <property type="gene ID" value="MXAN_5880"/>
    </dbReference>
    <dbReference type="GeneID" id="41363119"/>
    <dbReference type="KEGG" id="mxa:MXAN_5880"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155445_0_0_7"/>
    <dbReference type="OMA" id="HWRLQRQ"/>
    <dbReference type="OrthoDB" id="1307204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="25947" checksum="6BF48A79D4906E2F" modified="2006-07-11" version="1">MRPMRSFGGGGGGMGLPGLETTASKLAVALVAGSVMFHLTKSQSGGLLLLFPDLVFGKLYLWQPLTYAFIESSPIGIIFGAIITWSIGGYLESIWGSRRLLMVALGIAVSAGLITSLLAMLVPGATVQAYAGGNVMTSVLWVSYGLSIGRGQTNFWGLPLSGNALAGIGAGFVVLSAVTSGWQTQVPDLLGLCMAFAYVRGASPRKLWLHLQHWRLQRQLKGRSKHLQVVRQDRPDRDQYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0E9</accession>
    <name>Q1D0E9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555688.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91467">
        <property type="protein sequence ID" value="ABF91467"/>
        <property type="gene ID" value="MXAN_5737"/>
    </dbReference>
    <dbReference type="GeneID" id="41362980"/>
    <dbReference type="KEGG" id="mxa:MXAN_5737"/>
    <dbReference type="HOGENOM" id="CLU_1376871_0_0_7"/>
    <dbReference type="OMA" id="FTEAVHM"/>
    <dbReference type="OrthoDB" id="1478875at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188103" evidence="1">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="198" mass="21391" checksum="F5BF78EFEE6D24F0" modified="2006-07-11" version="1">MHSRTLVMAATLGLMACARQVPASATPTSTSTEPRAVRLLLDTPARETHTLTRLREDIEVDATEGERTPRVVATGQTPTLSLDGHRARLYGDAKGTLGIAVDNFLLLEVLDASGQVTRRATVGFTEAVHMGREQVDSVGRRAFNFEAGEVDITHLLPDSAPFQVRATALDTWGVGRVSDVYLLLAPGSRADNDDLRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0I0</accession>
    <name>Q1D0I0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555657.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5705"/>
    <dbReference type="EnsemblBacteria" id="ABF89751">
        <property type="protein sequence ID" value="ABF89751"/>
        <property type="gene ID" value="MXAN_5705"/>
    </dbReference>
    <dbReference type="GeneID" id="41362950"/>
    <dbReference type="KEGG" id="mxa:MXAN_5705"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_7"/>
    <dbReference type="OMA" id="HGVHLCD"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="48239" checksum="8CC062A5DDDFCB0E" modified="2006-07-11" version="1">MDLLLTGGTVVTMNREREVLVDADVLVQDGRIAKVGRGLKPRGTRRVVDVTGKVVLPGLIHGHLHACQTLFRGRADGLELLDWLRERIWPFEASHDAASMRASADLTFAELIRSGATAALDMGSVYHYDAVFESARDSGFRLVGGKAMMDAGAGVPAGLRESTEDSLKESLALKERWHGTHGGRLRYAFAPRFVLSCTPELLREVARLAKEHGLRIHTHASENAKETDAVRQYTGGEDNVAFFHTVGMSGPHVTMAHCVWLSQEEQDILRDTRTVVCHCPGSNLKLASGIAKVPELLEAGVAVALGADGAPCNNTLDIFYEMKLAAVMHNPRVGPCAMTPMRVLEMATLHGARALGLEDEVGSLEPGKRADITVVDVSGLHAGPTPEDVLVPLVHSARGSDVAHVFIDGQPVLRDGVLTTLDAPSVLANANAQVARILKRRQKKARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J5</accession>
    <name>Q1D0J5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase, Slt family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555642.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5690"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87503">
        <property type="protein sequence ID" value="ABF87503"/>
        <property type="gene ID" value="MXAN_5690"/>
    </dbReference>
    <dbReference type="GeneID" id="41362935"/>
    <dbReference type="KEGG" id="mxa:MXAN_5690"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009520_1_3_7"/>
    <dbReference type="OMA" id="IVPQNDM"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188111" evidence="2">
        <location>
            <begin position="19"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="448"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="549"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="629"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="676" mass="73573" checksum="4FE21C49B8A271D2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0L0</accession>
    <name>Q1D0L0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fimbrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555628.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5675"/>
    <dbReference type="EnsemblBacteria" id="ABF88145">
        <property type="protein sequence ID" value="ABF88145"/>
        <property type="gene ID" value="MXAN_5675"/>
    </dbReference>
    <dbReference type="GeneID" id="41362919"/>
    <dbReference type="KEGG" id="mxa:MXAN_5675"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098626_0_0_7"/>
    <dbReference type="OMA" id="CLWPVGL"/>
    <dbReference type="OrthoDB" id="1992780at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028188">
        <property type="entry name" value="Pilin_PilA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14245">
        <property type="entry name" value="Pilin_PilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="25974" checksum="5FEF1CA0849A4790" modified="2006-07-11" version="1">MPALVRGSHMCQGALSMAANLECPKCGSELDVTGRGPGAIIRCACGNLSAVPKRSYWASPRGVALALGVFLLCPCVGILAAIAIPNYNKLPVRSKQQECKANLRGLYAAQRNHNAEHGTFEPRIVNAGFIPERGNRYAYFTGTGPLVTRDAEGDAVPADAGGIGVDRSRDASRRAITLADLPAWVSRQVGVFGTCPDCYVTMGCAGNIDIDDTVDVWLISTKPLKDEYGEAVPPGTPTNVVNDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Z5</accession>
    <name>Q1D0Z5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase, cbb3-type, subunit III</fullName>
            <ecNumber evidence="8">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ccoP</name>
        <name evidence="8" type="ORF">MXAN_5539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5539"/>
    <dbReference type="EnsemblBacteria" id="ABF89331">
        <property type="protein sequence ID" value="ABF89331"/>
        <property type="gene ID" value="MXAN_5539"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5539"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047545_1_0_7"/>
    <dbReference type="OMA" id="YDGIEEH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032858">
        <property type="entry name" value="CcoP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038414">
        <property type="entry name" value="CcoP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14715">
        <property type="entry name" value="FixP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="18800" checksum="F0B4A7599DEA800E" modified="2006-07-11" version="1">MHSVYDGIEEHDNHLPNWWLFILWTSIIFSAGYWFWYHIAEVGPGQLGEYAAESAEVAKRASGNAPASDGMLLALAKDPASLESGKQVFQANCAACHGVQGQGSIGPNLTDAYWMHGGGPMAIHKVVADGVVAKGMPAWERTLGAERVKAVTAYLLTLKGTNAPGGKEPQGEPEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D138</accession>
    <name>Q1D138_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555450.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5492"/>
    <dbReference type="EnsemblBacteria" id="ABF87347">
        <property type="protein sequence ID" value="ABF87347"/>
        <property type="gene ID" value="MXAN_5492"/>
    </dbReference>
    <dbReference type="GeneID" id="41362746"/>
    <dbReference type="KEGG" id="mxa:MXAN_5492"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_35_2_7"/>
    <dbReference type="OMA" id="QIRGLGC"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="32947" checksum="2EA44D6B87641EC3" modified="2006-07-11" version="1">MSGMNVTLEHARALDALARHGTFTAAAEALRKGHTAVMYALRTLEAQTELTLLDRRGYRTRLTPAGERILEHCRKLLAAERELEAACAEIRAGWEPALRIVFDGIFPAEPLLRVLKELRAEGASTRFHVSAEFLSGVEAAFVREEANLMVTLLPPTVPGLRTYRLPELKAILVAHRGHPLARRRGPLKDEDLAEHLVLTVRGSDPRLQLSTGELEARSTVHLNDFAAKKAAILEGLGFGWLPEYMATRELRRGELKALKLAGDATHAFRPQLHHHSGIPLGRAARRIVQALTETESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1C5</accession>
    <name>Q1D1C5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF92078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_5401"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_416668_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="658" mass="71794" checksum="45BE327178AA54CE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1M1</accession>
    <name>Q1D1M1_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_5301</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88051">
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        <property type="gene ID" value="MXAN_5301"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5301"/>
    <dbReference type="HOGENOM" id="CLU_3186172_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="46" mass="5427" checksum="75EBB4E3C7C96D55" modified="2006-07-11" version="1">MKSAFKGEQVKAVLSRWHDHFRVRLWVPTESRTVQTRAMAPEEQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W1</accession>
    <name>Q1D1W1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator SocA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">socA3</name>
        <name evidence="3" type="ORF">MXAN_5210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5210"/>
    <dbReference type="EnsemblBacteria" id="ABF88556">
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        <property type="gene ID" value="MXAN_5210"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="HARGYDA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21385" checksum="A6D96D9BD764C5DE" modified="2006-07-11" version="1">MGRPRGFDRDEALVEAMRVFWARGYEGTSIQDLVDAMGVNKPSLYSIFGCKEELFREAVELYDRLEGIHTTRSLEDAPSARAAVEEMLRANARAYTASDKPRGCMIVLSSLLGSPENERVRTFLAENRLRGERALKQRLERGILDGDLPASAEVGMLAAFYTTVLEGLSIQSRDGASAKKLAAIIDAAMLAWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D269</accession>
    <name>Q1D269_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555074.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5100"/>
    <dbReference type="EnsemblBacteria" id="ABF88414">
        <property type="protein sequence ID" value="ABF88414"/>
        <property type="gene ID" value="MXAN_5100"/>
    </dbReference>
    <dbReference type="GeneID" id="41362384"/>
    <dbReference type="KEGG" id="mxa:MXAN_5100"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_7"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="29399" checksum="E841A28B0F21F600" modified="2006-07-11" version="1">MNPMILVTAATGKLGRLVVAGLLEKVPAKDIAIAVRDPSKASDLAAKGVQVRQADYSKPETLGPALAGADKVLLISSSEVGQRAAQHQAAVDAAKKAGVRLLAYTSILHADTSGLLLAGEHKATEEAIRASSIPFVFLRNGWYTENYTENLAPALAHGALIGSSGQGRSAAATRADYAAAAVAVLTGTGHENKIYELAGDTAFTAAELAAEVSRQVGTTVVYKDLSQADHAGALIGVGVPAPFAELLADSDAGVARGEMNDSSGDLRRLIGRPTTPLADAVAAAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D271</accession>
    <name>Q1D271_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ig domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5098"/>
    <dbReference type="EnsemblBacteria" id="ABF87265">
        <property type="protein sequence ID" value="ABF87265"/>
        <property type="gene ID" value="MXAN_5098"/>
    </dbReference>
    <dbReference type="GeneID" id="41362382"/>
    <dbReference type="KEGG" id="mxa:MXAN_5098"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375458_0_0_7"/>
    <dbReference type="OMA" id="WHCLVSE"/>
    <dbReference type="OrthoDB" id="331848at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="739" mass="76625" checksum="F2C351B1FE83ABBE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D280</accession>
    <name>Q1D280_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555063.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5089"/>
    <dbReference type="EnsemblBacteria" id="ABF89660">
        <property type="protein sequence ID" value="ABF89660"/>
        <property type="gene ID" value="MXAN_5089"/>
    </dbReference>
    <dbReference type="GeneID" id="41362373"/>
    <dbReference type="KEGG" id="mxa:MXAN_5089"/>
    <dbReference type="eggNOG" id="ENOG50334IY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136189_2_1_7"/>
    <dbReference type="OMA" id="LRMKYVQ"/>
    <dbReference type="OrthoDB" id="2048823at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="104" mass="11382" checksum="D9950776B6CD4A9C" modified="2006-07-11" version="1">MSSGDEKRGETFVMRGEARSASEESISFSTFIVGLGTAVLIHLGGAPNPETGQTEKDLPLARQNLDLLSMLRAKTRGNLTAEEEKLFDGLLADLRLRYVEATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D323</accession>
    <name>Q1D323_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstS</name>
        <name evidence="6" type="ORF">MXAN_4788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554775.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4788"/>
    <dbReference type="EnsemblBacteria" id="ABF88388">
        <property type="protein sequence ID" value="ABF88388"/>
        <property type="gene ID" value="MXAN_4788"/>
    </dbReference>
    <dbReference type="GeneID" id="41362087"/>
    <dbReference type="KEGG" id="mxa:MXAN_4788"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_5_1_7"/>
    <dbReference type="OMA" id="KMGYIPM"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027141822" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="29066" checksum="614A8338CE7A382B" modified="2006-07-11" version="1">MKSLLKPLLAVFLLALPAVAQAGTVTIKGSDTMVILGQRWAEAFMKKNPNIKVQVTGGGSGVGLAALQNGTTDIAMSSREMKKAEADKLRARYKAPPAQRSVAKDGVTFYVHQGNPVSALTTEQLMKIYVGDITSWKQVGGADAPIVAYSRENSSGTYVFVKDMVLDGEDFAPAIQTLPGTAAVVNAVSKEKNSLGYGGAAYAEGIKELKVKKGNEEIAPSADNIKSGKYPLARDLFFYLRAEPTGDIKAFIDFALSPEGQAIVTQVGYFPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D337</accession>
    <name>Q1D337_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554761.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4774"/>
    <dbReference type="EnsemblBacteria" id="ABF88346">
        <property type="protein sequence ID" value="ABF88346"/>
        <property type="gene ID" value="MXAN_4774"/>
    </dbReference>
    <dbReference type="GeneID" id="41362073"/>
    <dbReference type="KEGG" id="mxa:MXAN_4774"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_1_0_7"/>
    <dbReference type="OMA" id="RLDHRNP"/>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="21637" checksum="8369C2CB2A23B6AC" modified="2006-07-11" version="1">MLVKVDQIKDAGLKLEEPVNLELLGETLGGAASGEDTGFRATAPATLKASLRKLSGGVLLEGRFTVDVTSPCKRCLADVAMKVPVEFTLNLVPESLARGDDFKDDDEKAMEKKERSQGESGGSFELDDVDQELFDGKTINLDPIVREQLLLALPMNAVCRDDCKGLCSQCGANRNEVACTCETRPVDPRLAPLKNIKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D372</accession>
    <name>Q1D372_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554726.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4739"/>
    <dbReference type="EnsemblBacteria" id="ABF92523">
        <property type="protein sequence ID" value="ABF92523"/>
        <property type="gene ID" value="MXAN_4739"/>
    </dbReference>
    <dbReference type="GeneID" id="41362038"/>
    <dbReference type="KEGG" id="mxa:MXAN_4739"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743384_0_0_7"/>
    <dbReference type="OMA" id="GEFETCK"/>
    <dbReference type="OrthoDB" id="674119at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="41695" checksum="D2786DBD5DC952A1" modified="2006-07-11" version="1">MSLQGTLKDFGIGDILQLIGQQQKTGTLHVRAKDQEVRIGFNDGHIIKAESVTRKRKELIGAMLVRSELITETQLEAALETQRRTLKRLGDVLVSSQALTAERFQAMMQLQATETLYRLFTWKSGTYEFIQEPVEPDAEAIHPLRAETVLMEGFRMVDEWPVIRQKIHRDDLVFERIKALPQPRGEEGGELGAIGPSERRIYDELSPGRDLRKLVDISCLGEFETCKALYNLVKGEYVRPILPEGAPAPVSGDQRLLARVAGPLGRLVATVGVLAAVVLVVPRALRPDHEAGVAAVFADSAAQRHVSQAQRVRIEAALEVFRLERGELPERLDSLVQAGLLKPGELKYPWREEYYYRRLAARQFILLPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D383</accession>
    <name>Q1D383_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane protein, OMP85 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4728"/>
    <dbReference type="EnsemblBacteria" id="ABF88491">
        <property type="protein sequence ID" value="ABF88491"/>
        <property type="gene ID" value="MXAN_4728"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4728"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_1_1_7"/>
    <dbReference type="OMA" id="IFMPAFG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="243"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="326"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="746" mass="84051" checksum="735116FEEA8DB249" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D398</accession>
    <name>Q1D398_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipopolysaccharide core biosynthesis mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554700.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4713"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92215">
        <property type="protein sequence ID" value="ABF92215"/>
        <property type="gene ID" value="MXAN_4713"/>
    </dbReference>
    <dbReference type="GeneID" id="41362012"/>
    <dbReference type="KEGG" id="mxa:MXAN_4713"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_1_0_7"/>
    <dbReference type="OMA" id="IAPNFKR"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="156"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="37422" checksum="D367379AC96C3BD7" modified="2006-07-11" version="1">MTLIVHPHFHHRYTGVTRHVETVVPALVRDSGSETRVIGSGLSEGLPRITWPELLRRLRREPVVWHAHRNNELLVGMLLKLLGREVRLVFTRHTSMAPSGFTRFIARGADALVSLTKQVADVIALPSTVVSHGIDLTRFHPPEDRDAAWRKLGLGGRYGIGVIGRIRKEKGQGDFVQAIRPLLPAHPDWQPVLVGLAKGPDLDWLNQQMAGIEDRIALPGEQSVIEPWYQGLSILVHPSYAEGYSLVHVEAMASGCCVVASKLPYLDTLIEHGRTGFFFEPGDVQGLRELLDMLMREPERARQIGQNAAEEARRRCGVEHEARALADVYRATVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3C8</accession>
    <name>Q1D3C8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554670.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4679"/>
    <dbReference type="EnsemblBacteria" id="ABF90304">
        <property type="protein sequence ID" value="ABF90304"/>
        <property type="gene ID" value="MXAN_4679"/>
    </dbReference>
    <dbReference type="GeneID" id="41361977"/>
    <dbReference type="KEGG" id="mxa:MXAN_4679"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048408_0_0_7"/>
    <dbReference type="OMA" id="DCGRHMA"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="445" mass="48548" checksum="7F27F3F807303A73" modified="2006-07-11" version="1">MSAGRPVPTGLAVALLAAGLLPAALAVASPAFGWLALATDVAVLALCAVDFLRAPRAQSVRVWRRVEPVLSSGTRNAVHVALERQDTGTAPLHVEVRDEPPEDMASSGHRQSLTLPAARSTPQELTYFVTPPSRGDARFGDVHLRLRGPLGLCARQVRVPATMDVKVYPDLTALTREALALAHASDAPSARTQRRRASEGREFESLREYRPGDDYRHIDWKASARHAHTLVRTWQPEQHQPVLLLLDCGRHMAGRIQERRKLDHAVDAALRLARVGLEAGDVVGVLAFASGVRAYLPPRKGREHLRLITESLYRTEAALEESDYGRAFDFAFARQTRRALVVLFTDLVDPDASASLLTRTLALRPRHLPVVASLLDEDVQAAAHGVPAQTQDAYARQAAARLETEYRRTATTLRDAGALVIRAPARGFGAATLNAYLDVKARGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L7</accession>
    <name>Q1D3L7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554583.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4588"/>
    <dbReference type="EnsemblBacteria" id="ABF92431">
        <property type="protein sequence ID" value="ABF92431"/>
        <property type="gene ID" value="MXAN_4588"/>
    </dbReference>
    <dbReference type="GeneID" id="41361888"/>
    <dbReference type="KEGG" id="mxa:MXAN_4588"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_4_3_7"/>
    <dbReference type="OMA" id="LMMSAMN"/>
    <dbReference type="OrthoDB" id="1421045at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="359" mass="38236" checksum="1615A723AEC4009B" modified="2006-07-11" version="1">MVLPGKGMGWKTFFLALKDEWTRDEVGDVAGALTFRMILALFPFLLFLVSLAGLLIEPAQAQVLIQELARVAPREVTSILSERIEALANSRPVGLLTVGGVGAVWAASAGVVALMTALNKVYGVTESRPIWKLRGIALLVTLGGAAVAILAAFAVIVTPVIAGKLPGGLGTVLMWLRLPVAGLLMMFLWAVLYYVLPDVNQKFRFITPGSVVGVLIWVFASWGFSQYVANFGKYDVNYGAIGGVIVMLLWMWISAQVILLGAEINAILEHRSPDGKAPGQKVPEQGKALTATKTELEAGGASLPGAPGFQPVVDPVTGRPLDDPPSAPPRLRDTPLAAAFKWTVGMGLGLFLLRKSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3P7</accession>
    <name>Q1D3P7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554553.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4558"/>
    <dbReference type="EnsemblBacteria" id="ABF87807">
        <property type="protein sequence ID" value="ABF87807"/>
        <property type="gene ID" value="MXAN_4558"/>
    </dbReference>
    <dbReference type="GeneID" id="41361859"/>
    <dbReference type="KEGG" id="mxa:MXAN_4558"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993624_0_0_7"/>
    <dbReference type="OMA" id="YAHRRAE"/>
    <dbReference type="OrthoDB" id="1061029at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="29370" checksum="31371EA82FF23BB4" modified="2006-07-11" version="1">MSTAPHLEAGGLLLIADESLSPVLVEQAAPVLAQGGMALCQGPGSPSGPRRLVLFDGKLTPAHAEALRGEPPALLLATRASDGRPSPWETRLLGDLLRGAPLLPAGASRHRLQSVADINATGEAAAQAVTQARGSRTAAALVGDVVHELAANAMWDAPVDAQGQHRYAHRRSEVREVAPEDACELSFVVEEGRMWLEVVDRFGGLRPGPFARALGGWGGRVQVDASGGGAGLGLRRILEHSDVVAVRVAAGRESRVLCVVDLGEARRRATQPKSLLFCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D421</accession>
    <name>Q1D421_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554430.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4431"/>
    <dbReference type="EnsemblBacteria" id="ABF91005">
        <property type="protein sequence ID" value="ABF91005"/>
        <property type="gene ID" value="MXAN_4431"/>
    </dbReference>
    <dbReference type="GeneID" id="41361743"/>
    <dbReference type="KEGG" id="mxa:MXAN_4431"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_7"/>
    <dbReference type="OMA" id="PITPFDA"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="37521" checksum="191131EBD643F950" modified="2006-07-11" version="1">MATHFDPSAAAQPDSGVFGLPHSPEEAHVILIPVPFEATTSYGGGTSEGPTAVLEASRQVDLFDVETGRPYERGIAMLPEPQELRDWNTRAKERAQVVIEAGGIHSGEAALIQAAQDVNVLCDQMNEHVYRTTKHWLDQGKRVAAVGGDHSISYGIIRAHAEKYPGLGVLHLDAHADLRVAYEGFTWSHASIMYNVAERIPGVKTLVQVGLRDMSAEEYQYIADSNGRVHGFFDAVLQNKRFDGVPWNRQVDEMVALLPKQVYLSFDIDGLDPVLCPHTGTPVPGGLSFAEAVALIAGVVRSGRTIVGFDLTEVAPDPEGGEWDGNVGARLLYKMIGWMLKSQQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4A5</accession>
    <name>HUTI_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazolonepropionase</fullName>
            <ecNumber evidence="1">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutI</name>
        <name type="ordered locus">MXAN_4345</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554346.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D4A5"/>
    <dbReference type="SMR" id="Q1D4A5"/>
    <dbReference type="STRING" id="246197.MXAN_4345"/>
    <dbReference type="EnsemblBacteria" id="ABF88285">
        <property type="protein sequence ID" value="ABF88285"/>
        <property type="gene ID" value="MXAN_4345"/>
    </dbReference>
    <dbReference type="GeneID" id="41361657"/>
    <dbReference type="KEGG" id="mxa:MXAN_4345"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_7"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 4 5" key="2">
        <citation type="journal article" date="2017" name="Angew. Chem. Int. Ed." volume="56" first="9986" last="9989">
            <title>AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus.</title>
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                <person name="Bock T."/>
                <person name="Luxenburger E."/>
                <person name="Hoffmann J."/>
                <person name="Schutza V."/>
                <person name="Feiler C."/>
                <person name="Muller R."/>
                <person name="Blankenfeldt W."/>
            </authorList>
            <dbReference type="PubMed" id="28508504"/>
            <dbReference type="DOI" id="10.1002/anie.201701992"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS)</scope>
    </reference>
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            <dbReference type="EMBL" id="ABF87277.1"/>
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    </evidence>
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        <source>
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    <sequence length="246" mass="26132" checksum="3C0C5C69BEB98DD5" modified="2006-07-11" version="1">MSATLDITPAETVVSLLARQIDDGGVVATGVASPLAILAIAVARATHAPDLTYLACVGSLDPEIPTLLPSSEDLGYLDGRSAEITIPDLFDHARRGRVDTVFFGAAEVDAEGRTNMTASGSLDKPRTKFPGVAGAATLRQWVRRPVLLVPRQSRRNLVPEVQVATTRDPRRPVTLISDLGVFELGASGARLLARHPWASEEHIAERTGFAFQVSEALSVTSLPDARTVAAIRAIDPHGYRDALVGA</sequence>
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    <accession>Q1D4I5</accession>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Field C."/>
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                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-05" db="PDB data bank">
            <title>Crystal structure of AibR in complex with isovaleryl coenzyme A and operator DNA.</title>
            <authorList>
                <person name="Bock T."/>
                <person name="Volz C."/>
                <person name="Mueller R."/>
                <person name="Blankenfeldt W."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.92 ANGSTROMS)</scope>
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    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2017" name="Nucleic Acids Res." volume="45" first="2166" last="2178">
            <title>The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.</title>
            <authorList>
                <person name="Bock T."/>
                <person name="Volz C."/>
                <person name="Hering V."/>
                <person name="Scrima A."/>
                <person name="Muller R."/>
                <person name="Blankenfeldt W."/>
            </authorList>
            <dbReference type="PubMed" id="27940564"/>
            <dbReference type="DOI" id="10.1093/nar/gkw1238"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
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        <property type="protein sequence ID" value="ABF87995.1"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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        <property type="chains" value="A/B=1-228"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9 10 11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5K7F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="5K7H"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="5K7Z"/>
        </source>
    </evidence>
    <sequence length="228" mass="25372" checksum="994866C9CE01C04E" modified="2006-07-11" version="1">MTNTGGRKPDEGERYRAILETAARLICDRGYEGTSMQEIAAACRMTKAGLYHHIQNKEQLLFAIMNYGMDLFEEQVLSRVQDIANPVERLRACMRHNILLVTRGWSKEVIIILHEHATLTGETRAFIDARKKKYVDFLEEAFSQASQQGLIRPVDPTVGAFSFLGMVLWIYKWFKPDGRLTDEQIADGMVGMLFPPFAAAGDTAGQAGPSPLRMVPSVSATGTDSEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4V5</accession>
    <name>Q1D4V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Frizzy aggregation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frzA</name>
        <name evidence="2" type="ORF">MXAN_4143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554146.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D4V5"/>
    <dbReference type="IntAct" id="Q1D4V5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4143"/>
    <dbReference type="EnsemblBacteria" id="ABF93093">
        <property type="protein sequence ID" value="ABF93093"/>
        <property type="gene ID" value="MXAN_4143"/>
    </dbReference>
    <dbReference type="GeneID" id="41361462"/>
    <dbReference type="KEGG" id="mxa:MXAN_4143"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_4_7"/>
    <dbReference type="OMA" id="PEQEFFC"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="17110" checksum="26ED29B05B545A64" modified="2006-07-11" version="1">MAPDRALAAQARPEQEFFCFRVGDLRLGVPSENVLEVLRAGLLTPLPRTPSFIMGVTGHRGEVLPVLDLLRFLSKGEARIGPRTRLFVGVTGSYVAGVVADTVLGLRRIPVADILPPPLGGDAAAEHLLGVVQASGNQEAINLLNFSKLLQTARQRAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D505</accession>
    <name>Q1D505_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carotenogenesis protein carS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carS</name>
        <name evidence="2" type="ORF">MXAN_4090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554097.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D505"/>
    <dbReference type="STRING" id="246197.MXAN_4090"/>
    <dbReference type="EnsemblBacteria" id="ABF92626">
        <property type="protein sequence ID" value="ABF92626"/>
        <property type="gene ID" value="MXAN_4090"/>
    </dbReference>
    <dbReference type="GeneID" id="41361419"/>
    <dbReference type="KEGG" id="mxa:MXAN_4090"/>
    <dbReference type="eggNOG" id="ENOG5031TKG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178474_0_0_7"/>
    <dbReference type="OMA" id="APEWARN"/>
    <dbReference type="OrthoDB" id="1906784at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12840">
        <property type="entry name" value="CarS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033807">
        <property type="entry name" value="CarS_antirepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041199">
        <property type="entry name" value="CarS_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18354">
        <property type="entry name" value="SH3_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3_18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="12210" checksum="D7E57DA5C2E9BD8E" modified="2006-07-11" version="1">MIQDPSLIICHDVDGAPVRIGAKVKVVPHSEDGTISQRFLGQTGIVVGLVFDDPATQYPDDPLIQVLVEGLGEDLFFPEELELAPEWARNRIAQHRQAVRTGGRSSLERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5B4</accession>
    <name>Q1D5B4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553989.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3979"/>
    <dbReference type="EnsemblBacteria" id="ABF90704">
        <property type="protein sequence ID" value="ABF90704"/>
        <property type="gene ID" value="MXAN_3979"/>
    </dbReference>
    <dbReference type="GeneID" id="41361311"/>
    <dbReference type="KEGG" id="mxa:MXAN_3979"/>
    <dbReference type="eggNOG" id="ENOG50344TJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193827_0_0_7"/>
    <dbReference type="OMA" id="WYPDIRV"/>
    <dbReference type="OrthoDB" id="1271856at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="27727" checksum="BEDF6001019E8BCD" modified="2006-07-11" version="1">MLDMHTMQWRSLDEMMVGLRPPENCCLEQLSRDSVVQVTALLGKWYPDIRVGTESRHLEPAFYDQCVCIQGESPDRPVYAILGRDRDTQEVIGLLTLEKNARGLQLSAAMGAVEPSQRGLGLGQFGISLLEQVGRNIGAEVVLYYSTLKMARAQRNAEHRGFKLVGLVPAFDVDAIAPNTVKRVYEAIYAKVLVGPEKIHLPDWNALIPTTRALYTHLFGQHPAAAILENRNGVSIPASAPVPISAPEAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5J9</accession>
    <name>Q1D5J9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">acpP</name>
        <name evidence="5" type="ORF">MXAN_3894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1 2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3894"/>
    <dbReference type="EnsemblBacteria" id="ABF88042">
        <property type="protein sequence ID" value="ABF88042"/>
        <property type="gene ID" value="MXAN_3894"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3894"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_3_7"/>
    <dbReference type="OMA" id="AFGMEIP"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="76" mass="8616" checksum="5C2970E1D4710778" modified="2006-07-11" version="1">MCDIVKLIVKDHSGADFESITPEARLIEDLGMDYLDHIEFVMDLEDTFVIEIPDEEAEKIITVGDACDYVIKNLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K1</accession>
    <name>Q1D5K1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.79" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553902.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3892"/>
    <dbReference type="EnsemblBacteria" id="ABF91650">
        <property type="protein sequence ID" value="ABF91650"/>
        <property type="gene ID" value="MXAN_3892"/>
    </dbReference>
    <dbReference type="GeneID" id="41361224"/>
    <dbReference type="KEGG" id="mxa:MXAN_3892"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_0_7"/>
    <dbReference type="OMA" id="DCQIGPN"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008925">
        <property type="term" value="F:maltose O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20479" checksum="B360A9352D3B9313" modified="2006-07-11" version="1">MKTERQKMLDGELYDPFDAELVAARNRARDLCQVLNATREGEQEERRRILQALVGVGGDTVWMQPPFFCDYGSNIELGQRVFFNFNCIVLDVCRVSIGDYTLFGPGVQIYTPMHPFNAELRRKEEFGKPVTIGSDVWVGGGAIILPGVRIGSRAVIGAGSIVTRDVPDGVFAAGNPCRVIREITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5P2</accession>
    <name>Q1D5P2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553861.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3849"/>
    <dbReference type="EnsemblBacteria" id="ABF87749">
        <property type="protein sequence ID" value="ABF87749"/>
        <property type="gene ID" value="MXAN_3849"/>
    </dbReference>
    <dbReference type="GeneID" id="41361182"/>
    <dbReference type="KEGG" id="mxa:MXAN_3849"/>
    <dbReference type="HOGENOM" id="CLU_2143155_0_0_7"/>
    <dbReference type="OMA" id="ADEPPMG"/>
    <dbReference type="OrthoDB" id="1812971at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="112" mass="12330" checksum="A42E3F4E9BDF2AB0" modified="2006-07-11" version="1">MYLVITFLEQLEGTERAIRRLREFGIPEPLVVRARSAAAALSAEVPVFAGLRSLALGADDDRVILVSLLPGLPAEEMERLVQRVQLEMDADEPPMGRLVAMPVISAPTHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5S4</accession>
    <name>Q1D5S4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium bile acid symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553829.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3817"/>
    <dbReference type="EnsemblBacteria" id="ABF91395">
        <property type="protein sequence ID" value="ABF91395"/>
        <property type="gene ID" value="MXAN_3817"/>
    </dbReference>
    <dbReference type="GeneID" id="41361149"/>
    <dbReference type="KEGG" id="mxa:MXAN_3817"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039013_1_0_7"/>
    <dbReference type="OMA" id="FFFYGLK"/>
    <dbReference type="OrthoDB" id="1317830at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="35209" checksum="7BFA4C055BB65192" modified="2006-07-11" version="1">MPLRLVKRLARDWFLPGMFAAVILAALFPEFGTSGGPMHADVVADVGIFAVFLLHGLGLPAAQLRAGVVTWRVHVVVQAFTFVVFPLLWWLGDVLVGRWMPADLSLGLLYLCAVPSTISSSVAMTGVARGNVPAAIFNASLSSLLGIVLTPLIIGLFASATGHSLSMGQAILKLSALLLLPLALGQLLRPLVGGWFARYRPYTNAFDRVVILVLVYSSFCDSIASGLFSDYGAAVLGIAFAGAVLILAIVLMLTTRTARALGFSKEDEITVVFCGSKKTLASGVPMARLLFGANPALGLIVLPLMFYHQAQLLVCSLLAERYAKRPAGQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6C5</accession>
    <name>Q1D6C5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86909">
        <property type="protein sequence ID" value="ABF86909"/>
        <property type="gene ID" value="MXAN_3610"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3610"/>
    <dbReference type="HOGENOM" id="CLU_3138050_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="49" mass="4495" checksum="8C64C76C069E00D1" modified="2006-07-11" version="1">MARPQDVQAGMDGGAYAGGLAALGSADTCVVAWAGAGGTVTSKAPGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6J0</accession>
    <name>Q1D6J0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase, iron-sulfur protein</fullName>
            <ecNumber evidence="9">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhB</name>
        <name evidence="9" type="ORF">MXAN_3540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553569.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3540"/>
    <dbReference type="EnsemblBacteria" id="ABF86260">
        <property type="protein sequence ID" value="ABF86260"/>
        <property type="gene ID" value="MXAN_3540"/>
    </dbReference>
    <dbReference type="GeneID" id="41360885"/>
    <dbReference type="KEGG" id="mxa:MXAN_3540"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_7"/>
    <dbReference type="OMA" id="CPKGISL"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="29341" checksum="63E7AD6891FD4FF2" modified="2006-07-11" version="1">MDTAQASAVTTKTITFRIWRQDDPAKPGHFDEFKVPYAKGANVISCLMEIQRNPVTVEGKRVAPVIWDAACLEEVCGSCAMNINGRVRMACSALIDKLEQPITLEPMSKFPVVRDLTVNRDRMFDALKRIKGWVPIDGTHNLGPGPRQAPVDQSVMYVLSTCITCGSCLEACPQVTQENDFVGAAAISQARLFNMNPTGKMNSEERVRSLMGPGGIQDCGKAQNCVKVCPKEIPLVTSIAVMNREVTKLTIKDIFFQDEAPKGHGSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S0</accession>
    <name>Q1D6S0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3456"/>
    <dbReference type="EnsemblBacteria" id="ABF90807">
        <property type="protein sequence ID" value="ABF90807"/>
        <property type="gene ID" value="MXAN_3456"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3456"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_2_7"/>
    <dbReference type="OMA" id="GWGRQFF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="360" mass="38752" checksum="8CD76CE1FE7A3714" modified="2006-07-11" version="1">MDGRLAAARIDRAPPPDHLLGPLAVHLEVIGACNLTCTHCFAGELPRNQSPLSVKEMDALFAQLAGLGSFRLGLTGGEPLMRKDLLDILDAATGHGLHPCITTNALLIDERWARELGKRELVWLNVSLEGAQAGTNDAVRGAGVFDRVMEKLALLGQHARFTLAFTLTRDNVAEVEACVELARRVGAHTAVFRPLYPVGTATRHPELMPTFDGYVDALARLERVEADSDLFALDPFSPSAREELRGVVTEGPGCGAANTVASVSVQGNVNPCSFLGRAFESGNIRTRPFEDIWRDGQSFQRLRAKQTGDRFTGGCRARAQFYNGSAFAEDPWQAQSLGAATESHPLPVLGAERGQGGACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D741</accession>
    <name>Q1D741_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF85993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ABF85993"/>
        <property type="gene ID" value="MXAN_3333"/>
    </dbReference>
    <dbReference type="GeneID" id="41360686"/>
    <dbReference type="KEGG" id="mxa:MXAN_3333"/>
    <dbReference type="eggNOG" id="COG1716">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="RILEGHP"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_8"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="261"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF85993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="566" mass="59659" checksum="4620E29896D1F780" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7G1</accession>
    <name>Q1D7G1_MYXXD</name>
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        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_3211"/>
    </dbReference>
    <dbReference type="GeneID" id="41360565"/>
    <dbReference type="KEGG" id="mxa:MXAN_3211"/>
    <dbReference type="eggNOG" id="COG2214">
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    </dbReference>
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    <dbReference type="OrthoDB" id="428318at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
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    </dbReference>
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        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="384" mass="42759" checksum="E68312A49721E13C" modified="2006-07-11" version="1">MRGLSGDFSTMPLKDLVVYLGNRRATGSLKVERGDVRKQLELREGHVVSASSNQPREFFGQFLINMGHLTEDQLEKAFSTQAQTRIFLGKILVMTGLVPEATVRGTLSHKFREMILDAFHWEDGDFLFEAADTAPEVAGLEVSVDLLDVHREGEFRETAWQAIHAVFPSGAVRLSVDERKLPERKPGSMDERIVQLIKEGLTIDGIALALHATDFFLYQRLYALYRLDAVKVSDEPPESEMSVVEEENGERGIIGSETSSDEVLQAAQLFLDAGNARDGEALARRAHEMSPSPRTAEFVKAAQEKLLVHLRRELADPPRVPTLQVAPGHLKTLQLSAPERYLLSRIDGRRDVAAIVHVSPLQELDALKFFAGFVDATLVKLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7N3</accession>
    <name>Q1D7N3_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="ABF87060"/>
        <property type="gene ID" value="MXAN_3137"/>
    </dbReference>
    <dbReference type="GeneID" id="41360496"/>
    <dbReference type="KEGG" id="mxa:MXAN_3137"/>
    <dbReference type="HOGENOM" id="CLU_1893948_0_0_7"/>
    <dbReference type="OMA" id="CQFAAPD"/>
    <dbReference type="OrthoDB" id="1997732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188469" evidence="1">
        <location>
            <begin position="36"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14008" checksum="D59185AC59BE2B42" modified="2006-07-11" version="1">MKTGIGATSRFFRPFTGAALTAVLGLVGVPAAAAAQGVVPQVSCYQRATDGGLDDALATQLCRGARSSTPADCFVRAQDEGSLTQSQAVQLCQFAAPDEDPAACYIQARKQTFTAPTRVLQLCQPAVQTCPGNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7P0</accession>
    <name>Q1D7P0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3130"/>
    <dbReference type="MEROPS" id="S13.004"/>
    <dbReference type="EnsemblBacteria" id="ABF86924">
        <property type="protein sequence ID" value="ABF86924"/>
        <property type="gene ID" value="MXAN_3130"/>
    </dbReference>
    <dbReference type="GeneID" id="41360491"/>
    <dbReference type="KEGG" id="mxa:MXAN_3130"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017692_1_2_7"/>
    <dbReference type="OMA" id="KHSDNLY"/>
    <dbReference type="OrthoDB" id="720131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188339" evidence="2">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="494" mass="52597" checksum="800045499C1507F5" modified="2006-07-11" version="1">MRRILSASLLLVAPLVLSGCFRETRPEGDTLPSLARALFETLEAEGALASAYVVDAQTGEPLFTHREHVRLLPASTLKVVSTASVLSALGADFRFQTPVALEGTLDGGLFLGDIVVEPTGDPSLGSWRFPETALACEQVADALQARGIRQWRGQVRVRGAKEAEFPFGPGWAWDDAAYAYSAAPTAFVFRENVVDVALSRAAGAACAQPPTIQVTPTFATLPAVVGVDTNAERPSLACVRQRGGPGVRCLWRSTADTCPRSAAVRLSVDEPEQLFSACVEAALLARGIPRLPMTLEAPTPRQPAVPAPLVTLVSPPLSELVKVTNKESLNLYAERLGLRFARELTGTESYGALRTALTEELTRRGIPSRDLRPVDGSGLSRYNLATARGLVRVIFTSLREAYGTALLDSLPVAGLDGTLAARPVTADTAGHIRAKTGTLSGQRCFVGVVDRPGDARHPRVVFALMLGNMDDGTALPANEAFDRFTAGLVTLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7V5</accession>
    <name>Q1D7V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adventurous gliding motility protein CglB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cglB</name>
        <name evidence="3" type="ORF">MXAN_3060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553115.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3060"/>
    <dbReference type="EnsemblBacteria" id="ABF89989">
        <property type="protein sequence ID" value="ABF89989"/>
        <property type="gene ID" value="MXAN_3060"/>
    </dbReference>
    <dbReference type="GeneID" id="41360422"/>
    <dbReference type="KEGG" id="mxa:MXAN_3060"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660269_0_0_7"/>
    <dbReference type="OMA" id="DGLPNCN"/>
    <dbReference type="OrthoDB" id="739502at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187974" evidence="1">
        <location>
            <begin position="20"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="50"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="44206" checksum="E925BFE6A4628C9A" modified="2006-07-11" version="1">MRSKLPLLSALSVGAVVLACQTYDFEPVEPLAIAQTTVEEVIKARQSKPNIMLLVDTSGSMTYPVNPSPACDVEFKGSIVPCGGEAPCNVDVCPTRWTTLQSVVPQFLENSGRFVRFALTTYPETRGGESIPDLCRASTAGALLKTLPEQEDDDSLLAHANEINTLLQGIPNGGEGRPLGGTPTSGSLNFVGGLEGLQDPDRENFVILLTDGLPNCNAANPNSGANPELCKCTIEGNQCQSGYLNRGCLDTDASVTAVRELHEKGIQTIVIGFGAETAVGDGPAVLEAMARAGGFKRTCSAERPCGEGDTCNPTTGLCNRSFFQAGNQAELASALEEISLAVKIPEPCLIRLDGPQRPTDPKLLVVYVEGERTPSSDSTWTLNDDGVRFTGQICERILASTPEAPVKIEVRAIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D858</accession>
    <name>Q1D858_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase I</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2955"/>
    <dbReference type="EnsemblBacteria" id="ABF92231">
        <property type="protein sequence ID" value="ABF92231"/>
        <property type="gene ID" value="MXAN_2955"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2955"/>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_7"/>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20274" checksum="C11520264F5D29DE" modified="2006-07-11" version="1">MARAVADFLRAAGLNLQDVHLADTPTRVAEAWAAEFLDGYSRTPEQALGETFPAPPGSSGELVVVTDLRFHSMCPHHLLPLTGRAHVAYVPGKRVVGFGRLSSLVDCFAHRLILQEDMAREVARSLAQVLGSPATACIIEAEQACLRLRGDKQRDAVTHAEAYEGTLRRDGPLRRELWARLGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G1</accession>
    <name>Q1D8G1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2851"/>
    <dbReference type="EnsemblBacteria" id="ABF85992">
        <property type="protein sequence ID" value="ABF85992"/>
        <property type="gene ID" value="MXAN_2851"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2851"/>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707545_0_0_7"/>
    <dbReference type="OMA" id="LWDGPNE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P/Homo B" evidence="4">
        <location>
            <begin position="335"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="464" mass="48790" checksum="C5165D97D50706C8" modified="2006-07-11" version="1">MCRQRQESGGAQRQRVGDSHGAQDCHGGGRIPHGFGWIASRMGDVLCAGQVLRYMVRMKLKLPLFLSLSTVLPALISCGAPTSTDTAHEAVVLGTQAQALATGTPAAEGVLSFLNDYSISYTVLDLEVPLDSQAAQALIDFREGPDGVLHTGDDRRFVSIEQVDAVPYVGPAALAALEAYAKGTGRVELPVDGHVGTFHGVAFNVAEARRAILAANTESASNLETVFGIPAAAVQSLVAARPILHMVQLSRLANVDAVTMGQLKVHTQLAAEGDPCTGPTLCQPGLVCEGRPGDGSSPYGRCVDASYFPGYGEVCSRFVACQTPKSVCIGLASGSVEGYCAPAWMGSSFTEYSDLRLQSTNPLVTAPLVAVGLATVPMDINVELDIVHTAPHRLVLTLEDPGGETALLWDGPNEGTPPSRIVVTRGIPRDGAVNGRWKLHIANPSGVGSGTLRSWTLKLTSRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G7</accession>
    <name>Q1D8G7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552906.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2845"/>
    <dbReference type="EnsemblBacteria" id="ABF90124">
        <property type="protein sequence ID" value="ABF90124"/>
        <property type="gene ID" value="MXAN_2845"/>
    </dbReference>
    <dbReference type="GeneID" id="41360216"/>
    <dbReference type="KEGG" id="mxa:MXAN_2845"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_0_0_7"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="143"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22599" checksum="28C2BF134593C910" modified="2006-07-11" version="1">MDEKRYPIPAGLHRVEQDIQKSRFITTAAHAPTVEEAKAFIARVREEFADATHNCWAFVVGPPGSTAQVGMSDDGEPHGTAGRPMLTALLHGGVGDVAMVVTRYFGGTLLGKGGLVRAYTAGVQQALESLPTTERVRKTRLAVEVEYTHVDGLRRLLPSYEVQVLAEEYSATVGYRLELPVTQVEALRTALNDLTLGQVLVEPLDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R3</accession>
    <name>Q1D8R3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-dependent Clp protease, ATP-binding subunit ClpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2743"/>
    <dbReference type="EnsemblBacteria" id="ABF91981">
        <property type="protein sequence ID" value="ABF91981"/>
        <property type="gene ID" value="MXAN_2743"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2743"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_7"/>
    <dbReference type="OMA" id="KTHIARN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="101"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="3">
        <location>
            <begin position="300"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="44725" checksum="70DD0F84F6B036EE" modified="2006-07-11" version="1">MCGGQAGWRGGRPVLLLPRADPPFNSYPFPVSPEGRVETRGGYMESSARREEALLTPREIYERLDRFVIGQDGAKRAVAIAAHNHLKRLLARRLRRTSLIKKSNILLMGPTGSGKTHIARNLADILHVPFTTVDATEYTEAGYYGKDVEVMISDLLFKANHSVEDTQRGIIFIDEVDKIARRSQGARNGAGSRDIGGEGVQQSLLKLLEGREVYVPLNVTQAWNKSDFVQVDTRDILFICAGTFSDLHDDGDEGRRAMGFGAEDSAKRSQKRISTRQLTDFGMLAEFLGRLPVVVQLERLGEEDLMRVLTEPPDSIVREFRELLSMDDLEVDFADPGLREVVRYSVERGLGARGLRSVLEHVMADVMFEAPERRRRQVMVDAGFVRERLRGLDSTQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8W3</accession>
    <name>Q1D8W3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552761.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2693"/>
    <dbReference type="EnsemblBacteria" id="ABF88287">
        <property type="protein sequence ID" value="ABF88287"/>
        <property type="gene ID" value="MXAN_2693"/>
    </dbReference>
    <dbReference type="GeneID" id="41360071"/>
    <dbReference type="KEGG" id="mxa:MXAN_2693"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822954_0_0_7"/>
    <dbReference type="OMA" id="FESLRWV"/>
    <dbReference type="OrthoDB" id="421309at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="39834" checksum="2857D18497FF5536" modified="2006-07-11" version="1">MALHGDLFSYPLPEFLQWLDSSRKTGTLQLSWEAGERKLFLLSGQVGATAAEGLRGRVARLLTLSKLASGTKVLAGFDELARTPDVDAAFDIHGIQARWIRDLGREELFAAMTDLTIAGRGTFHWTEDADRSGEDWVPSDMGIRELLFESLRWVDEQPDVDKALPIDALSVRALAPPSPSQPLMHRIILGLCTSPQNLGRLRLSMGVSRSSVTRRVHELLRSKLVEVDGAPQVEADPVAEMLEKGAVLMREGQYDAAGIVCASLLASDPADRRVREFARLVQREHVAALYSDMPPLMVPLMIHDPQGQALLKPEERQIAGLVNGTWDVSTLVLASPARELETLKTLAKLQRMGLLQLVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D993</accession>
    <name>Q1D993_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552631.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2561"/>
    <dbReference type="EnsemblBacteria" id="ABF92739">
        <property type="protein sequence ID" value="ABF92739"/>
        <property type="gene ID" value="MXAN_2561"/>
    </dbReference>
    <dbReference type="GeneID" id="41359939"/>
    <dbReference type="KEGG" id="mxa:MXAN_2561"/>
    <dbReference type="HOGENOM" id="CLU_943053_0_0_7"/>
    <dbReference type="OMA" id="FRLCATT"/>
    <dbReference type="OrthoDB" id="1609539at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="32483" checksum="7C2041094CFB7C22" modified="2006-07-11" version="1">MPSGREGVSCGLPLASLGVPMRLTLVGLLLFASTALGQTVTFSASAEILQNDQIVVSQENCGLDRTVNWTRVAGNCDVLHLWLSNESSCTGTPGAGDLSLADIPVNDTRLTGTVTFNASDALVADGAKCESQTSTKTFRLCATTKRLGTLGGCDDSFVSVGTPSISFIYDPEPPAVPETPSVTGLDAALSVSVKVPSDAVSMEVQVLQSVPGEDGGVGAGEVISKKRQVSSNAVFRMDQGLENGVEYAVQAIAIDRAGNQSEPSPAATGTPVASNGFYQGYLGAGGAETGGCAAAGGGITGCAMLASLGVWLSSRRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I7</accession>
    <name>Q1D9I7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552538.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2466"/>
    <dbReference type="EnsemblBacteria" id="ABF90274">
        <property type="protein sequence ID" value="ABF90274"/>
        <property type="gene ID" value="MXAN_2466"/>
    </dbReference>
    <dbReference type="GeneID" id="41359849"/>
    <dbReference type="KEGG" id="mxa:MXAN_2466"/>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103733_0_0_7"/>
    <dbReference type="OMA" id="LYIENGF"/>
    <dbReference type="OrthoDB" id="1574489at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="72"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="25104" checksum="1DC74AEDB8A57F7F" modified="2006-07-11" version="1">MRRRGPDAGDEGQGGDQGQRSNKSADTHGGASVGERPRPGNARSGLNPGCFPGVTPVEWRPMRTLLCTLGFTLALLSASPAHAQFANRSLGLSLGYMDFNRTNGLDDAFFVGVDASLYIENGFEVVSLSKIAFPRDTTDRNEKRVVGLAPSIGIRYLLMEESIRPYVGSDLSYLVVFKNSVSNFVGIGPNVGIDFFMSDSVSVGARAQYNFYIALNEKTQRTLTLSAGAAAYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9X8</accession>
    <name>COAA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaA</name>
        <name type="ordered locus">MXAN_2325</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552400.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D9X8"/>
    <dbReference type="SMR" id="Q1D9X8"/>
    <dbReference type="STRING" id="246197.MXAN_2325"/>
    <dbReference type="EnsemblBacteria" id="ABF92345">
        <property type="protein sequence ID" value="ABF92345"/>
        <property type="gene ID" value="MXAN_2325"/>
    </dbReference>
    <dbReference type="GeneID" id="41359712"/>
    <dbReference type="KEGG" id="mxa:MXAN_2325"/>
    <dbReference type="eggNOG" id="COG1072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053818_1_1_7"/>
    <dbReference type="OMA" id="RKYTQVS"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000325557" description="Pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <sequence length="317" mass="35871" checksum="A5AEB81E03635103" modified="2006-07-11" version="1">MALATGLSPAMFIDLERDAWRALRAATPLPLKSEDIDGLRGLGEHLDLDEVVDVYLPLSRLLNLQVAAAQRLWAEQQAFLGGSTQKVPYIIAIAGSVAVGKSTTARILQALLKRWPDHPRVELVTTDGFLFPNDVLTERDLMKRKGFPESYDRRALVRFLAELKAGRAEVAAPVYSHLVYDVVPGEAQVVRQPDILILEGLNVLQAGAQEGKQMPATFLSDFFDFSIYVDAHEHDIRRWYVNRFLKLQQTAFRDERSYFRRFSELNHEQAIQLAESVWGEINGPNLAQNIAPTRSRARLILLKGPDHKVKRVRLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y4</accession>
    <name>Q1D9Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2319"/>
    <dbReference type="EnsemblBacteria" id="ABF89969">
        <property type="protein sequence ID" value="ABF89969"/>
        <property type="gene ID" value="MXAN_2319"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2319"/>
    <dbReference type="eggNOG" id="COG3541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643895_0_0_7"/>
    <dbReference type="OMA" id="TTYWEVR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="45480" checksum="6E6095542761C0B7" modified="2006-07-11" version="1">MDRLSVPLPHGTEVTTRVERLASGGRRIPQGVVGRVVRAHDGGFDVQIVGVGEVWFARDELVPRRPGQVQFAQRREAAWSALTPCVVLETRVGSHAWGLADERSDVDVRGVFALPLPWRFGLVDAPRDLVSADGSTMYWEVHKAVEQALRADPNTLETLFVPGAKALDPVGEWLLAERDAFVSKALFGSFGRYAMSQLDKLTRSQRLAEHRDLLLEWLCEEPAPDLDEVARRLSAVSPREAPSAQDALLAAKTYVKQLYRSLWDQGLLAANDFKALTAYARSGGQRPPSARELRPKNAYNLLRLVATATGWLREGAPVFEASGALKARLLDIKAGRVPLEDVLRDAEALAPDLEAAHRESRLPEHPDYERADRLLRRVGEELARRWVLKEPGPLGRDAPEAPAMGWRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA32</accession>
    <name>Q1DA32_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90840">
        <property type="protein sequence ID" value="ABF90840"/>
        <property type="gene ID" value="MXAN_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2270"/>
    <dbReference type="HOGENOM" id="CLU_365518_0_0_7"/>
    <dbReference type="OMA" id="AQWTAIV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188417" evidence="2">
        <location>
            <begin position="22"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="768" mass="81851" checksum="103D53D43F19EE88" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG5</accession>
    <name>Q1DAG5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552213.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2134"/>
    <dbReference type="EnsemblBacteria" id="ABF88828">
        <property type="protein sequence ID" value="ABF88828"/>
        <property type="gene ID" value="MXAN_2134"/>
    </dbReference>
    <dbReference type="GeneID" id="41359533"/>
    <dbReference type="KEGG" id="mxa:MXAN_2134"/>
    <dbReference type="HOGENOM" id="CLU_2917804_0_0_7"/>
    <dbReference type="OrthoDB" id="2191607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="61" mass="6716" checksum="A12420B085B5DE95" modified="2006-07-11" version="1">MADNNDSAERTDWTKVLLKCPECGKEKPVVPDFGLMTLGGHPPSPQFRCNVCRIAIVTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT5</accession>
    <name>Q1DAT5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552093.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2003"/>
    <dbReference type="EnsemblBacteria" id="ABF87117">
        <property type="protein sequence ID" value="ABF87117"/>
        <property type="gene ID" value="MXAN_2003"/>
    </dbReference>
    <dbReference type="GeneID" id="41359413"/>
    <dbReference type="KEGG" id="mxa:MXAN_2003"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_6_1_7"/>
    <dbReference type="OMA" id="QIRPVHH"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="90"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="29044" checksum="AE598E0232AC2E3E" modified="2006-07-11" version="1">MPSPRRPLLGLLALLWLVPVIAGAAERPARIIIDPGHGGAKEGAKGPGKLREKDVALQISLRLRDKLEAAGGDVFLTREHDTLVSLTERVAWSNDHAPDLFISIHANSMPTKRMRARTEGVETYFLSASASGDAALAVADRENAEAPMSRATRTDSTLAFILQDLARTEAHADSSRLAYAIHPRLVRGTRAVNRGVQQAPFFVLSGVECPAVLVEVGYISHPVEGPRLGRPEYQEKLAEAITEGVLAFLKETRRRDAARGTEVAGPVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAU0</accession>
    <name>Q1DAU0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bamD</name>
        <name evidence="4" type="ORF">MXAN_1998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1998"/>
    <dbReference type="EnsemblBacteria" id="ABF86457">
        <property type="protein sequence ID" value="ABF86457"/>
        <property type="gene ID" value="MXAN_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1998"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065982_2_1_7"/>
    <dbReference type="OMA" id="VERQHPY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00922">
        <property type="entry name" value="OM_assembly_BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009018906" description="Outer membrane protein assembly factor BamD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="44"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="30074" checksum="B7D1FD8C9F1E62C1" modified="2006-07-11" version="1" precursor="true">MVGMRSAVAFLSAFLLFGTGCASLTQGQAGEPDYAAVADENLRLGSEALENKDFFRAQKYFEYVRTKFPYQEAAREAELKLADVDFEREAFPEAKEQYQSFIKLHPTHAKVDYAAFRSAMTHVRAYPSEFFALPPSREKDQGEIRSALVAMEEFLRQYPQSQYVAEAKTQREDARRRLASHELYAAQFYQKRERWKAVAQRLEGLLRRYPGTEYEEEALFDLHDAYVKLNDTEKAQDTLRQVLRRLPGTPAAERAQRMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB46</accession>
    <name>Q1DB46_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1881"/>
    <dbReference type="EnsemblBacteria" id="ABF89738">
        <property type="protein sequence ID" value="ABF89738"/>
        <property type="gene ID" value="MXAN_1881"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1881"/>
    <dbReference type="eggNOG" id="ENOG5030ZBD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088906_0_0_7"/>
    <dbReference type="OMA" id="FLGEPHP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="27589" checksum="3C70FC89E01BA268" modified="2006-07-11" version="1">MPERGVKHMANMWEQTAAMAKQHEQQGGAWLKLANDGDTAVVVFLGEPHPREVVFVDNKFVPFDETLKAQGQKPSLRVALNVAVYGTREVKVMEQAVTFFNTLMELRAKYGLERWAFEVKRRGAAKDTKTTYSILPDRQLTQEEMAAFQSLQQHDLPKLYAAEAAGAASGASPAGASSAKPAEPVDVKLAQAMATALKALPREAVDRFLQKFAVQRIRDIPASKGELARAFVDSLVAEYSAESVADVDPFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH4</accession>
    <name>Q1DBH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89651">
        <property type="protein sequence ID" value="ABF89651"/>
        <property type="gene ID" value="MXAN_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1749"/>
    <dbReference type="HOGENOM" id="CLU_2807937_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="67" mass="7504" checksum="1C5789A8DDEE97F2" modified="2006-07-11" version="1">MNHFHGVQDYLPHARSMLALVRERSVITPNGTETSRELHFFVSTRKPTDAEAMATFGLGKPRDGTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC10</accession>
    <name>Q1DC10_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551672.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1561"/>
    <dbReference type="EnsemblBacteria" id="ABF89365">
        <property type="protein sequence ID" value="ABF89365"/>
        <property type="gene ID" value="MXAN_1561"/>
    </dbReference>
    <dbReference type="GeneID" id="41359006"/>
    <dbReference type="KEGG" id="mxa:MXAN_1561"/>
    <dbReference type="eggNOG" id="ENOG5030VW8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942378_0_0_7"/>
    <dbReference type="OMA" id="MRRITCL"/>
    <dbReference type="OrthoDB" id="1382012at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="337" mass="35881" checksum="262BDD7B045EC9DB" modified="2006-07-11" version="1">MVPARFARRLSRLTRTGPPGLCNPLHAHPRPCSGRASCSREVAPGMMVALHGGMTRREAAVSCTPGEAPMRRITCLALTVLVTACGGGAPTQEEVDAARQRVERVVAASHQVRGALEALGVLPVYTCGEPRRAFLSTAAHGVRGRWACAHAAVEPHDSVTDRVVLTFDEGGCDVHGLRFAGQAAFLYRGGEDLMEVEADLRGLTVDGHPLQAEVGYGTCGDETRLWADVQGGVPGREGHTFRVDGRVGMRAGMPVFGGTSLVLDGPGELTGPQGTDRLTLTGLHYEVGEYLPKEGTAVLETADGRRVEARFQPVLWRLGKAEVTVDDLEPVTVPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCE9</accession>
    <name>Q1DCE9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551534.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1417"/>
    <dbReference type="EnsemblBacteria" id="ABF90426">
        <property type="protein sequence ID" value="ABF90426"/>
        <property type="gene ID" value="MXAN_1417"/>
    </dbReference>
    <dbReference type="GeneID" id="41358863"/>
    <dbReference type="KEGG" id="mxa:MXAN_1417"/>
    <dbReference type="HOGENOM" id="CLU_1037917_0_0_7"/>
    <dbReference type="OMA" id="FGGAPRH"/>
    <dbReference type="OrthoDB" id="1554021at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018636">
        <property type="entry name" value="DUF2058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09831">
        <property type="entry name" value="DUF2058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="30743" checksum="62FAA871F45FAC67" modified="2006-07-11" version="1">MQNLRDKLLKAGLVTEDQAKKVETKPSQAEARRPGLQEGGRSSGNRPPPRRDDNRTPGGPPRGEGGGRPSGGRDAGRREGGGRPGGGFGGAPRHGGGPQHGRPAAAAAERAIPKLPPMPGSKAYQRAESKRQVELDRALRELVLGSQVPVEAGETAFYFMTRKGKLRRLELSPAQAKQLEEGELGVVERPEPAQIEHSLVPSSAAEQMFALSKKSVRFLNRKENPVGFMNDEELKAQQAAEAAGTAPELPDEPEGGSEASAETASEASAETASEGEAAPTEPKASSEEAQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCN4</accession>
    <name>Q1DCN4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551449.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1332"/>
    <dbReference type="EnsemblBacteria" id="ABF90312">
        <property type="protein sequence ID" value="ABF90312"/>
        <property type="gene ID" value="MXAN_1332"/>
    </dbReference>
    <dbReference type="GeneID" id="41358778"/>
    <dbReference type="KEGG" id="mxa:MXAN_1332"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344794_0_0_7"/>
    <dbReference type="OMA" id="CHIEGHT"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="693"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="820" mass="87140" checksum="B14882A14E250BD5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD60</accession>
    <name>Q1DD60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">MXAN_1153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551273.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1153"/>
    <dbReference type="EnsemblBacteria" id="ABF92051">
        <property type="protein sequence ID" value="ABF92051"/>
        <property type="gene ID" value="MXAN_1153"/>
    </dbReference>
    <dbReference type="GeneID" id="41358604"/>
    <dbReference type="KEGG" id="mxa:MXAN_1153"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_0_7"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="137"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="478" mass="53042" checksum="37CC26AC8505F987" modified="2006-07-11" version="1">MSTETLQELTRRPYAAGFVTQLESDTFPPGLDEDVIRQISAKKGEPEFLLDWRLKAFRHWKTMKEPTWQAVTYAPIDYQAIRYYSAPKQKPVKASLDEVDPEILRTYEKLGIPLHEQKLLQNVAVDAVFDSVSVATTFKDKLAKAGVIFCSFSEAVREHPELVKKYLGTVVPYSDNYFAALNSAVFSDGSFVYIPKGVRCPMELSTYFRINAADTGQFERTLIVAEEGSHVSYLEGCTAPMRDTNQLHAAVVELVALDNATIKYSTVQNWYPGDAEGRGGIYNFVTKRGIAHRAAKISWTQVETGSAITWKYPSVILKGDDSVGEFYSVALTNHMQQADTGTKMVHIGKNSRSTIVSKGISAGRGQNTYRGLVKVLKSAENARNYTQCDSLLLGDKCGAHTVPYIEVKNASAQVEHEASTSKIGEDQLFYCRQRGISQEDAVSMIVNGFCRQVFKELPMEFAVEAQKLLGVSLEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD62</accession>
    <name>Q1DD62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Receptor family ligand-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1151"/>
    <dbReference type="EnsemblBacteria" id="ABF86259">
        <property type="protein sequence ID" value="ABF86259"/>
        <property type="gene ID" value="MXAN_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1151"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_7"/>
    <dbReference type="OMA" id="NAYDATH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="37647" checksum="80D9C22EA55B465E" modified="2006-07-11" version="1">MDSNTILLGEVGSLTGSEATFGVSARNGIELALNEANEAGGVKGKKLQVRVYDSQGRPEEGAQAVTRLITQDKVVAILGEAASSVSMAMAEKAQAGKVPMVTPTSTAPEVTQKGDYIFRVCFIDPFQGLAMAKFARENLQLSRVAVLRDNKSAFSMGLADVFTARFKEFGGEVPGDESYSKGDTDFRAQLTSLKRLKPDAVFVPGYYTDVGIIARQAREIGLKVPLLGGDGWDSDKLYELGGSALEGSYFANHYSPDNPDPVLQRFLARYKATYGGVPDSVAALAYDAARVTIDAMKRAPDLSGPSLRDAIAATKEFPGVTGKITLDANRDAVKEAVVLKVSGGKAEFVTTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD70</accession>
    <name>Q1DD70_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551263.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1143"/>
    <dbReference type="EnsemblBacteria" id="ABF87253">
        <property type="protein sequence ID" value="ABF87253"/>
        <property type="gene ID" value="MXAN_1143"/>
    </dbReference>
    <dbReference type="GeneID" id="41358594"/>
    <dbReference type="KEGG" id="mxa:MXAN_1143"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_1_1_7"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="12"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="43473" checksum="40C1E3BA3F4AC430" modified="2006-07-11" version="1">MPFDAPVDALTGMPAARFGLYLHFPYCLAKCPYCDFAVAVARQVPEERYARAVLAELDTRLAAEPSLAGKVLDSIFLGGGTPSLWHPRYVAQVLDGIAARLRVAPGVEVSLEGNPERADAERFAGYRAAGVNRLSLGVQSFQPETLKALGRAHDAAMVEGAVDAARSAAFPVVAMDFIYGVHGQTVAQVEADARRAVALAPEHLSTYALTVERDVLAEDTPLSKRLKRGELELPPDDTVVDMARVVREVYGAAGLHRYEVSNHARPGFSSRHNALYWTGGEYLALGVGATGMLLSPQPHRYVNLRSAERYLVEAEAGRLPEEGREPLGPEELFAERLAMGLRLVSGVDWEAVCERYGQPVEPRRAEVARLVAHGFATLRDGRLALTEKGADVHSAVCARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF04</accession>
    <name>Q1DF04_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0499"/>
    <dbReference type="EnsemblBacteria" id="ABF88316">
        <property type="protein sequence ID" value="ABF88316"/>
        <property type="gene ID" value="MXAN_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0499"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1395031_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="20875" checksum="6C808181AD168060" modified="2006-07-11" version="1">MNRCPPGRAHRRSPRMDPFTSEHLGDDGDAQVRGVGRIIDVHRDPVASTKVVMIPMLSGCKTTVTVKLALAPNAPRSQPTAEPLRWQLPCEDVTETKVAASELGRHGIRVNVVAPGAIQTPLAESVGLIEVMGHEFLARTPLGKPCGMPSDVAGVVSFLCGEDAAWITGETLSVDGGNHIRGLHSYWDMLSRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF30</accession>
    <name>Q1DF30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550606.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0473"/>
    <dbReference type="EnsemblBacteria" id="ABF90680">
        <property type="protein sequence ID" value="ABF90680"/>
        <property type="gene ID" value="MXAN_0473"/>
    </dbReference>
    <dbReference type="GeneID" id="41357966"/>
    <dbReference type="KEGG" id="mxa:MXAN_0473"/>
    <dbReference type="eggNOG" id="ENOG5032NQQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2024232_0_0_7"/>
    <dbReference type="OMA" id="RNPTWVA"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="149" mass="15571" checksum="C66B6698193F850C" modified="2006-07-11" version="1">MGQYLSRCRRVTLAPPSKGGRFMSHSYSKVFGALVLLGLAVSCRANHAPKVSTGPRPSPQVVGAGGVVSFVFEVEDPDGDAMTFQWQQLPAEPAGTFSDANARNPTWVAPEVSETTTFAIMVTVEDSEGDGILAQGPGVIVHAAASQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF48</accession>
    <name>Q1DF48_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550588.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0455"/>
    <dbReference type="EnsemblBacteria" id="ABF91266">
        <property type="protein sequence ID" value="ABF91266"/>
        <property type="gene ID" value="MXAN_0455"/>
    </dbReference>
    <dbReference type="GeneID" id="41357948"/>
    <dbReference type="KEGG" id="mxa:MXAN_0455"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574550_0_0_7"/>
    <dbReference type="OMA" id="DPWKELG"/>
    <dbReference type="OrthoDB" id="572473at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="576" mass="57695" checksum="8D97466F60E57C2D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF82</accession>
    <name>Q1DF82_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550554.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0420"/>
    <dbReference type="EnsemblBacteria" id="ABF90068">
        <property type="protein sequence ID" value="ABF90068"/>
        <property type="gene ID" value="MXAN_0420"/>
    </dbReference>
    <dbReference type="GeneID" id="41357914"/>
    <dbReference type="KEGG" id="mxa:MXAN_0420"/>
    <dbReference type="HOGENOM" id="CLU_2700910_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="7650" checksum="532993E18501539A" modified="2006-07-11" version="1">MGCQDLSWDLAGAAVEPSLDAEALAAASYDAHAPDEAARLRHAAARYAELLRRELASASSRPRLGGVGVDARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF97</accession>
    <name>Q1DF97_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ychF</name>
        <name evidence="6" type="ORF">MXAN_0405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550539.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0405"/>
    <dbReference type="EnsemblBacteria" id="ABF88488">
        <property type="protein sequence ID" value="ABF88488"/>
        <property type="gene ID" value="MXAN_0405"/>
    </dbReference>
    <dbReference type="GeneID" id="41357899"/>
    <dbReference type="KEGG" id="mxa:MXAN_0405"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_7"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="40253" checksum="7A7A0F473C680558" modified="2006-07-11" version="1">MGLSIGIVGLPNVGKSTLFNALSAAGAQAANYPFCTIEPNVGVVPVPDDRLDKLSALIKPLKKVPTSLEFVDIAGLVRGASKGEGLGNQFLGNIRQVNAVLHVLRCFEDDNVTHVEGGVNPVRDRDVVDTELCLKDLETVEKRRERSLKNTKVGGKAGEEAKAEVALLDRIKASLDNGITVRAQKLTEEESAVIHDLFLLTDKPVLYVANIGESELGKEDANPHVKAVREMAAKEGFEVVVLAAALESEIQQLPESERPGFLESAGLSEPGLHKVVRAGYKLLGLWTYFTVGEQECRAWTIHQGYKAPQAAGVIHSDFERGFIKAEVMRWEDLVKLGSESAVKEKGMLRVEGKEYVVQDGDCMHFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF99</accession>
    <name>Q1DF99_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit c</fullName>
            <shortName evidence="11">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpE</name>
        <name evidence="13" type="ORF">MXAN_0403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002636238.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0403"/>
    <dbReference type="EnsemblBacteria" id="ABF86931">
        <property type="protein sequence ID" value="ABF86931"/>
        <property type="gene ID" value="MXAN_0403"/>
    </dbReference>
    <dbReference type="GeneID" id="41357897"/>
    <dbReference type="KEGG" id="mxa:MXAN_0403"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_5_0_7"/>
    <dbReference type="OMA" id="QTAMIII"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="12">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="11">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF86931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="76" mass="7295" checksum="4FD4A282E78B884B" modified="2006-07-11" version="1">MTNLALAFLAAGLGAGLSIIGAALGIGKLAAAAMDATGRQPAAGGDIRTTMIIAAALIEGATLFALVVCILLATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC0</accession>
    <name>Q1DFC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550517.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0379"/>
    <dbReference type="EnsemblBacteria" id="ABF92319">
        <property type="protein sequence ID" value="ABF92319"/>
        <property type="gene ID" value="MXAN_0379"/>
    </dbReference>
    <dbReference type="GeneID" id="41357877"/>
    <dbReference type="KEGG" id="mxa:MXAN_0379"/>
    <dbReference type="eggNOG" id="ENOG50319Q3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048280_0_0_7"/>
    <dbReference type="OMA" id="WLCDGVA"/>
    <dbReference type="OrthoDB" id="713414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188671" evidence="1">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="47979" checksum="2B42DFB169A2B1F4" modified="2006-07-11" version="1">MKTVPCLLAWSAMLFLSGCADTGDDCDLVPLPGGLGQLPPLLSLELPAELHVQPSLNSTCEGLDTSQVPDSITAEVFDPNNHAVASEASLTGNGQAATVRFTPTTTGRHHVRVAFAPVGSLQQFGAYVSRAWTGGEPTVLPLPRCTQLDRTTHGTWLCDGVAVHTANGTQTPLGGVSGMPDVAVAGDVVWVVGEDRVRRFVDTGSELELTGSLLLNQRDTMKVIQNRLATADELWVLDSERLHRFAFTSEGVVVGATPTPWGRANQLPFGVDMVLGLLVRLGPDTVSVIQVTQEPDSRACTFRLGPSGAFVASEAPCQRLPGVPAGIEAGAVWTRVDTLLPPQPGQTLYRWAAVDGALTERGTLVVDAPLELVSAPLRPGFAIPFIQWRQSRIGSAVPVPPESQGPLGLELLPGNADLSPGLRTLSPRFYWEAGGGQGLGGTRVYERRASSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ6</accession>
    <name>Q1DFJ6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550441.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0297"/>
    <dbReference type="EnsemblBacteria" id="ABF90917">
        <property type="protein sequence ID" value="ABF90917"/>
        <property type="gene ID" value="MXAN_0297"/>
    </dbReference>
    <dbReference type="GeneID" id="41357796"/>
    <dbReference type="KEGG" id="mxa:MXAN_0297"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905084_0_0_7"/>
    <dbReference type="OMA" id="LCKIHHA"/>
    <dbReference type="OrthoDB" id="1629654at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="339" mass="38322" checksum="B759EE1BAA00A216" modified="2006-07-11" version="1">MHGGTRLVCTSPEVPVSPCIRPGPGSLAGLTNQDLDWPIRVAAMNALQHLVRQHGEVLSWDVIARGFTYQGETLNFANRARGIFWPRHMRETALSIKTTVPRQGREARYDDLRSNEGFQYRFQGTDVASRDNRRLVRGMEWDVPLIYFYGIEPGAYRPIWPVYISEANPAELSFTVVSAAPDAEVLAPGLHAADPKLLNLERRYATVQMKKRLHQAAFRQHVLRAYSQRCAVCRFPRPELLDAAHILPDRDERGRPEISNGLSLCKLHHGAFDTDLLGIRPDGIIEIAPRLLAERDGPTLEYGLKGFAGKALSILPEAPAHRPRREYLEARYERFRMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ7</accession>
    <name>Q1DFJ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, S1C (Protease Do) subfamily</fullName>
            <ecNumber evidence="2">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550440.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0296"/>
    <dbReference type="EnsemblBacteria" id="ABF90831">
        <property type="protein sequence ID" value="ABF90831"/>
        <property type="gene ID" value="MXAN_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="41357795"/>
    <dbReference type="KEGG" id="mxa:MXAN_0296"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_7"/>
    <dbReference type="OMA" id="DIIVAWN"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="313" mass="32828" checksum="CF9EEC43E31B43AD" modified="2006-07-11" version="1">MAPFRGLYLVPRKEHTMSTGLLQSLSHSLASIVERTAPGIVRVETRRRRGTTGIVWDAEGHILTTSQAVEHEGRLPIGLPDGRTVSAEFVGRDASTDLALLKAEATGLAPLTSAPLDDVKVGHLVIAVGRPGRTARATLGMVSTHGEGWRTHAGGRVERYLETDADLPPGFSGGALVDTEGRLVGLLTAAFSRTAAVVIATDTLTRVIASLKEHGGIRRGYLGVGAYPVRLPPHLGTGNEHGLICLSVDPNGPAHDAGLLLGDVLVSLGGQPLHGVEDLLGALSDEKVGTTLQVRVLRAGEVREVPITVGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM0</accession>
    <name>Q1DFM0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550417.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0272"/>
    <dbReference type="TCDB" id="1.B.14.12.3">
        <property type="family name" value="the outer membrane receptor (omr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89166">
        <property type="protein sequence ID" value="ABF89166"/>
        <property type="gene ID" value="MXAN_0272"/>
    </dbReference>
    <dbReference type="GeneID" id="41357772"/>
    <dbReference type="KEGG" id="mxa:MXAN_0272"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006935_0_0_7"/>
    <dbReference type="OMA" id="NLDARYE"/>
    <dbReference type="OrthoDB" id="76759at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188509" evidence="6">
        <location>
            <begin position="39"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="297"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="563"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1076" mass="115267" checksum="49F66D3DDF85C077" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT9</accession>
    <name>Q1DFT9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase, flavin-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550348.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0202"/>
    <dbReference type="EnsemblBacteria" id="ABF86334">
        <property type="protein sequence ID" value="ABF86334"/>
        <property type="gene ID" value="MXAN_0202"/>
    </dbReference>
    <dbReference type="GeneID" id="41357705"/>
    <dbReference type="KEGG" id="mxa:MXAN_0202"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028676_0_0_7"/>
    <dbReference type="OMA" id="EGVFYVD"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="431" mass="44535" checksum="F6D9FEAC68E65CB7" modified="2006-07-11" version="1">MKAPRVAVIGGGLGGLSAAALLARGGCAVTLFERSKHLGGRGQTSDVEGFRFNLGAHALYQGGAGMRVLGELGVKPAGGMPGAGSYLLSGGRLHTMPRGLVSLLTTDALGLPGKLELAKLLAGLGRVDLAPLANITTRDWVEQHLSNADARAFILALVRVMTYCADVDAMSAQSAVAQLQAKPAVLYVDGGWSTLVSELETRARDAGTRLELSARVSAVLLADTGARVRGVRLADGTEHAADAVVVAGGPGDIAALLPADALLAHDAARAVPVMAATLELGLSRLPRPDALFALGTDGPWYASVHSAVAKLAPEGGAMVHVMQYLGGRGPEASEARLEEVMDALQPGWRTSVVARRYRPSLLVSHWLPTAETGGLRGRPSVEVPHVPGLYRVGDWVGPEGLLAEASFASAESVARALVPGQQVASRRAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFU1</accession>
    <name>Q1DFU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550346.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0200"/>
    <dbReference type="EnsemblBacteria" id="ABF88094">
        <property type="protein sequence ID" value="ABF88094"/>
        <property type="gene ID" value="MXAN_0200"/>
    </dbReference>
    <dbReference type="GeneID" id="41357703"/>
    <dbReference type="KEGG" id="mxa:MXAN_0200"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_9_3_7"/>
    <dbReference type="OMA" id="PFQIMAN"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="162"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="318" mass="32490" checksum="90ACA4DB47CA4854" modified="2006-07-11" version="1">MTRAPGWSRVRPPAMSRTAGFLIVALSGVCFGALGLFGRLAYAAGTDVATLLFLRFSIAGAVLASVMVLRRQRWPRGGVLVVLMLLGAAGYFSQSGVYFFALQHAPAGLVALLLYSFPALVALVQRVVFKEHLGRVKWLAVVLSVGGTVLTADLSQGGATLPGVLLGLLSALFYTVYVVASGRVSGRAGPLASSTVILCSAGFSFGVAMLVRGPAFPGSVTGWAAVVGLALVATVAAVLLFFVGIQRIGPVNTSLVSNLEPLTAVVLGALFLDERLTPRQVLGGVLILGAAVMLARADVPRASPEPPAGGGAPGAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG61</accession>
    <name>Q1DG61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550226.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0079"/>
    <dbReference type="EnsemblBacteria" id="ABF90617">
        <property type="protein sequence ID" value="ABF90617"/>
        <property type="gene ID" value="MXAN_0079"/>
    </dbReference>
    <dbReference type="GeneID" id="41357586"/>
    <dbReference type="KEGG" id="mxa:MXAN_0079"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_18_2_7"/>
    <dbReference type="OMA" id="GWAGATM"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="24188" checksum="C92AAAA5FDCC55BC" modified="2006-07-11" version="1">MLAFLTLGSHPGRVSEASGTPGRQEQERSRVTRQRLMEAAIGALSELGWAGATMTVIAERAGVSRGACQHHFPTRADLVAAAVEYVGHQQVEAVLRKAAQLPADARRTEAILHMLAGIYLSPVFTAAVQLWVAAVADAELRAQLAPLEARVGREFHRLTVQLLGVDDSVAEVRELIQGTLDLIRGLALANLLRDDSARRKKVLHRWALTLDEALSARRTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGD1</accession>
    <name>Q1DGD1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550158.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86679">
        <property type="protein sequence ID" value="ABF86679"/>
        <property type="gene ID" value="MXAN_0008"/>
    </dbReference>
    <dbReference type="GeneID" id="41357516"/>
    <dbReference type="KEGG" id="mxa:MXAN_0008"/>
    <dbReference type="eggNOG" id="ENOG50316RS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2274335_0_0_7"/>
    <dbReference type="OMA" id="TREQKFA"/>
    <dbReference type="OrthoDB" id="1900710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="11718" checksum="50824515283AB06A" modified="2006-07-11" version="1">MPNRKYDPYTGGKEAATKPPYAPDRVERGLEADDTLPLYSADSIRDTREEKFALDSDSEVGGYVPDIRSPIDEADELERERRGRERAEERQVSDEEDEARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVG9</accession>
    <name>Q1CVG9_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7501"/>
    <dbReference type="EnsemblBacteria" id="ABF86410">
        <property type="protein sequence ID" value="ABF86410"/>
        <property type="gene ID" value="MXAN_7501"/>
    </dbReference>
    <dbReference type="GeneID" id="41364635"/>
    <dbReference type="KEGG" id="mxa:MXAN_7501"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_7"/>
    <dbReference type="OMA" id="YQQDEAW"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="108" mass="12853" checksum="B4C19676D66EFE3C" modified="2006-07-11" version="1">MMHTEPGVFGAISHPARRRMLDLLVDGDRPVNSIAENFEMSRPAVSQHLRVLLDAGLVTEQRHGRERRYRLVPERLEPVRDWIAHYERFWDDNFARLRRHLEKGDKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVM1</accession>
    <name>Q1CVM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557355.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7447"/>
    <dbReference type="EnsemblBacteria" id="ABF90320">
        <property type="protein sequence ID" value="ABF90320"/>
        <property type="gene ID" value="MXAN_7447"/>
    </dbReference>
    <dbReference type="GeneID" id="41364595"/>
    <dbReference type="KEGG" id="mxa:MXAN_7447"/>
    <dbReference type="eggNOG" id="ENOG502ZEIR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1445391_0_0_7"/>
    <dbReference type="OMA" id="WFALERR"/>
    <dbReference type="OrthoDB" id="1639535at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="19856" checksum="5DC8A6AF9548887C" modified="2006-07-11" version="1">MGRRHALRYTEPLPMAADSSAPPADATSTDSAIPSPALQRLWFALERHAWSFLTVVPAHPGAPALEAATAVLEAGAPYAYTQKVHLEDATGLSPTAAAQKVLELRERVSRGERVVAVIDSLMTHPASLPLALAADGCLLCVTLGETDFGAASKTLEFVGRERFLGSVTFPRLTKKQRRAASQKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVQ1</accession>
    <name>Q1CVQ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7416"/>
    <dbReference type="TCDB" id="2.A.66.12.12">
        <property type="family name" value="the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89586">
        <property type="protein sequence ID" value="ABF89586"/>
        <property type="gene ID" value="MXAN_7416"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7416"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534107_0_0_7"/>
    <dbReference type="OMA" id="IYYRTDM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="490" mass="52110" checksum="34CBD4E9BC47B0D4" modified="2006-07-11" version="1">MGAVRNGLQLGGSLLATYAIAMGVRFLLPAHLGPESFGRFNYADSFSAVFFIATHLGLEMYIRKEVSRRPEHASDFFGSTLLLRLGLTAVLMGAMALVMAHFDEPPEVRQLVYVFALAQSLIIINASVAALLHAKGKVAGLSVSNIVTKLVWGGGLLAVAVAGLPLPWLAVPLVASEAVKLGVGWYLAREHMGLTFKVDVPATLKVLKASLPFFITGAALAANGRLDVMILGMVSSHEEVGWYGAAWNIAGLTFFLNPVFGWVLMPLASRAAERSEAELTNLTRRSLEGTLAVTVPMMMLIVLGAPLWVGLMGGAFSESAMPLRLMSPLFVLAFVTMNAGLWLTMTNREWWVTITSVIGSVVLIPLLNLLLVPLMLSALGNGGGAAGTALSMLLMEICVTISLLGRMGKAAFDARLVSMMAKTAVICAAIAVLDQTLLAFLNPWVRITVEAVLYIVAVLATGAVRPGEVLQVVRIARRRGNPAPEAAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVR3</accession>
    <name>Q1CVR3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7403"/>
    <dbReference type="EnsemblBacteria" id="ABF87564">
        <property type="protein sequence ID" value="ABF87564"/>
        <property type="gene ID" value="MXAN_7403"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7403"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828547_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="36187" checksum="A885A1398117DD28" modified="2006-07-11" version="1">MDAPLASLRRAVFRLAEQGAALSALYHRARLLGCEHQPLKGPMLLAGNHGVWGYETPAFFHLIHQGTGRHPLRLTERGFFRIPLIHTVLPWLGGVEGTRANAMTALRAGSRVVCHPGSAWETFQREPRRLSPVELLRRLRDILATDLMPRLHELQVPTLVIQGGRDFAGAAPRRPRRGPAHPRSPAGAHPGRQPPALHAPPRCLQHAGRGLPPAAPGLSRHPHHEHRRHPPAPFRPAVPGPPPWTGGRRHAPAPLPAAGLTLHRRRDAGGGRGRREGAVRARAHGVVRPPERGRPDARGDAGGGAPVPAAAGPHRRGGRAGQRVAEAHPVRAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVT2</accession>
    <name>Q1CVT2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557296.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7384"/>
    <dbReference type="EnsemblBacteria" id="ABF87701">
        <property type="protein sequence ID" value="ABF87701"/>
        <property type="gene ID" value="MXAN_7384"/>
    </dbReference>
    <dbReference type="GeneID" id="41364543"/>
    <dbReference type="KEGG" id="mxa:MXAN_7384"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119503_0_0_7"/>
    <dbReference type="OMA" id="FRTYYDS"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="63"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="21396" checksum="BDAEB0B005CE1425" modified="2006-07-11" version="1">MRGGHGRGDVSLPPGSAASPPRDRPEGEGPGPSEGHVLEACAPFPWVTLSRGARQRMATERAQRFVDALAKLEKEGDLEALVSLFSDDAQVSNVASPQVFSGQEGARRFWREYKGTLQRVESTFRNMIEAGSRVALEWETQGTAHNGAAVAYEGVSIIEWDGDRIRRFYAYFDPHALGLELTSGNAPRSEVPATTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW8</accession>
    <name>Q1CVW8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">MXAN_7347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557260.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7347"/>
    <dbReference type="EnsemblBacteria" id="ABF91925">
        <property type="protein sequence ID" value="ABF91925"/>
        <property type="gene ID" value="MXAN_7347"/>
    </dbReference>
    <dbReference type="GeneID" id="41364508"/>
    <dbReference type="KEGG" id="mxa:MXAN_7347"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_1_7"/>
    <dbReference type="OMA" id="RHDHAVV"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="19197" checksum="346604A56FD59D4F" modified="2006-07-11" version="1">MARDIVIWPHKVLTSSTKPVTDFGPPLETLLEQMAESMKEAEGIGIAANQVGESLRVALVGREDGTFFEIVNPQILEKKEPVTMEEGCLSVPREWEKCPRFHKVKVRYQDKSAEWHELEAEGRLAHVLQHEIDHLDGHVFVDHLSSLKRTLILDRMKKLQKVKARQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW41</accession>
    <name>Q1CW41_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557188.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7269"/>
    <dbReference type="EnsemblBacteria" id="ABF90250">
        <property type="protein sequence ID" value="ABF90250"/>
        <property type="gene ID" value="MXAN_7269"/>
    </dbReference>
    <dbReference type="GeneID" id="41364434"/>
    <dbReference type="KEGG" id="mxa:MXAN_7269"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_0_0_7"/>
    <dbReference type="OMA" id="YGRIWTG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="619" mass="68367" checksum="62CC83645EE70394" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWL5</accession>
    <name>Q1CWL5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FrmR/RcnR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557014.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7095"/>
    <dbReference type="EnsemblBacteria" id="ABF90208">
        <property type="protein sequence ID" value="ABF90208"/>
        <property type="gene ID" value="MXAN_7095"/>
    </dbReference>
    <dbReference type="GeneID" id="41364270"/>
    <dbReference type="KEGG" id="mxa:MXAN_7095"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_3_0_7"/>
    <dbReference type="OMA" id="DCGPILQ"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="10251" checksum="A07EAFF546CE872B" modified="2006-07-11" version="1">MPHSPEEKKKALLRVRRIRGQTEALERALESGAECGTVLQQLAAIRGAINGLMSEVLESHIREEFGPASDEDPRHAQRVRDMTTLVRTYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWS5</accession>
    <name>Q1CWS5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7035"/>
    <dbReference type="EnsemblBacteria" id="ABF89231">
        <property type="protein sequence ID" value="ABF89231"/>
        <property type="gene ID" value="MXAN_7035"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7035"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_2_2_7"/>
    <dbReference type="OMA" id="LHPVDMP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="24747" checksum="7CDAEACECBE63EAE" modified="2006-07-11" version="1">MGAEEAGMKAVAIILAAGEARRMGHPKALIEHEGGKSFLQSLASTFGKAGSMVLGVVGKDSEAVREQHPGMELVEAERWQEGPLLSIKAGLDAALEAGADVVLLHPVDMPALRASTLKSLLKMAGDVDELLRPEFEGAPGWPLVLSRSGAERLRAAEGQQLEPALATMKVRRVPVKDPGVVVNINTPETYERLFGTQPRLAPPPKRRGAKRGTAPATSNVAELGGGSAPMAAASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX14</accession>
    <name>Q1CX14_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DbpA RNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6944"/>
    <dbReference type="EnsemblBacteria" id="ABF91905">
        <property type="protein sequence ID" value="ABF91905"/>
        <property type="gene ID" value="MXAN_6944"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6944"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2220328_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DbpA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="106" mass="11507" checksum="CB176B579877E51C" modified="2006-07-11" version="1">MVPEVLNPGERLGGVLRQPEGADVGERRLKSSPGEADGLAASDVGKIEFHDHHAFVAVSKRVAKMALQRLREECIKGRKTPHRARAVVASPSRFSKCEIIQVVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX66</accession>
    <name>Q1CX66_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556815.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6892"/>
    <dbReference type="EnsemblBacteria" id="ABF86506">
        <property type="protein sequence ID" value="ABF86506"/>
        <property type="gene ID" value="MXAN_6892"/>
    </dbReference>
    <dbReference type="GeneID" id="41364078"/>
    <dbReference type="KEGG" id="mxa:MXAN_6892"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019886_0_0_7"/>
    <dbReference type="OMA" id="GGLTKQC"/>
    <dbReference type="OrthoDB" id="989319at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="587" mass="63483" checksum="BF1AF63DE44B8BD1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA3</accession>
    <name>Q1CXA3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6853"/>
    <dbReference type="EnsemblBacteria" id="ABF93015">
        <property type="protein sequence ID" value="ABF93015"/>
        <property type="gene ID" value="MXAN_6853"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6853"/>
    <dbReference type="HOGENOM" id="CLU_1325186_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="207" mass="23364" checksum="241E7BFA81B79D2D" modified="2006-07-11" version="1">MIKSMDSFKGFFQSLPRVGAWFRQGDVQPEEIQVFWRHMQRCFPTDAVCSHTSPARLFPRAGVAPGHCLHLPFEVGVPRAGWDLWRQVVACTHAVQHVLQFEEDGLEVSLASSAARARSEAEALRCDLELHFWRHGTTPPLWSLAWRLRAQGCHAEDIAGAVHVLALSAASIRQGAVENEASHVALQWLEAHVPHLRWDRAYHSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ9</accession>
    <name>Q1CXJ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6757"/>
    <dbReference type="EnsemblBacteria" id="ABF93091">
        <property type="protein sequence ID" value="ABF93091"/>
        <property type="gene ID" value="MXAN_6757"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6757"/>
    <dbReference type="HOGENOM" id="CLU_1739434_0_0_7"/>
    <dbReference type="OMA" id="IPRQSAM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187724" evidence="1">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16326" checksum="C0AE4EE1678AE82D" modified="2006-07-11" version="1">MRRHVSSGRMLWALLGLGLLLPMAASAQDAKVQVQVEVVLASKKGTEVDPPELEKMKEQFQKQNFSFTSFKRLSNEVLTVSAKSASEVKLPNGANATLQLQGIKDGTATVRVAIPRQPTLDVELGRQGAVYQKAGKYVGGELILVLSPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL6</accession>
    <name>Q1CXL6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556665.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6740"/>
    <dbReference type="EnsemblBacteria" id="ABF89341">
        <property type="protein sequence ID" value="ABF89341"/>
        <property type="gene ID" value="MXAN_6740"/>
    </dbReference>
    <dbReference type="GeneID" id="41363932"/>
    <dbReference type="KEGG" id="mxa:MXAN_6740"/>
    <dbReference type="eggNOG" id="ENOG5032TAJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166822_0_0_7"/>
    <dbReference type="OMA" id="VILWIEE"/>
    <dbReference type="OrthoDB" id="2008003at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="11304" checksum="B3207E0A65B35138" modified="2006-07-11" version="1">MKVYLDDERATPDGWVRVRWPEEAISLLASGQVTELSLDHDLGDDTHGTGYDVLLWLEEAVATRGFVPPRVVQVHSANSSARQKMTLAIARIERFVQDGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ2</accession>
    <name>Q1CXQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556629.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6704"/>
    <dbReference type="EnsemblBacteria" id="ABF88164">
        <property type="protein sequence ID" value="ABF88164"/>
        <property type="gene ID" value="MXAN_6704"/>
    </dbReference>
    <dbReference type="GeneID" id="41363897"/>
    <dbReference type="KEGG" id="mxa:MXAN_6704"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509055_0_0_7"/>
    <dbReference type="OMA" id="LKPFIHV"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19418" checksum="44C7068AECFB9371" modified="2006-07-11" version="1">MTMKQVDAGVEVAPAPILDVAGLPNDLMAAVKFGLPTDEDMTAVADLRAGSEPWKSRGETQEDSLKALTQLKPFIHVAKLQSQLVGYVTVERDGPVPGAAYLRNIVVKPELRRKGLGNILLEQALKAARDMYRKTIALRVDPSNSPAVSFYRKEGFTTVATVVSKKSGKLRLLMSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXV3</accession>
    <name>Q1CXV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6653"/>
    <dbReference type="EnsemblBacteria" id="ABF87506">
        <property type="protein sequence ID" value="ABF87506"/>
        <property type="gene ID" value="MXAN_6653"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6653"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100954_0_0_7"/>
    <dbReference type="OMA" id="RDEACAV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="19617" checksum="BB813AECB720039B" modified="2006-07-11" version="1">MLVRGGVLGLTLEAVAAEADLSKPSLFYYFRSKEDLVGALAVEGLEREVKVLEAAVTAAASGVEALAALVRARVDLYAEDLDGFRVVYLWPQLTGRQSEAHQSRVLALSGQLNDVLEARLQADARAGRLAPGLQPRRLANLAWTVAHGVLSLGAGLEHSGVGTRFTLSQLRDEACAVLLRSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY15</accession>
    <name>Q1CY15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6587"/>
    <dbReference type="EnsemblBacteria" id="ABF92956">
        <property type="protein sequence ID" value="ABF92956"/>
        <property type="gene ID" value="MXAN_6587"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6587"/>
    <dbReference type="HOGENOM" id="CLU_1979134_0_0_7"/>
    <dbReference type="OMA" id="MLMAGKR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13301" checksum="D28EDA065364997E" modified="2006-07-11" version="1">MCAARPEENTAGTPAAQALPDLRRSSRRGSRAVVARCGVWRWMMLTAGKRLAVFSIREGKGGSIWVRAGSAFVNKDGSLNVLLDVLPLDGKLHVREAAEKRDTAGMSGGRYAGELGLDAAPVGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY46</accession>
    <name>Q1CY46_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556485.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6555"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87202">
        <property type="protein sequence ID" value="ABF87202"/>
        <property type="gene ID" value="MXAN_6555"/>
    </dbReference>
    <dbReference type="GeneID" id="41363760"/>
    <dbReference type="KEGG" id="mxa:MXAN_6555"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_7"/>
    <dbReference type="OMA" id="VEQWITL"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="411"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="456" mass="51003" checksum="91F767B7E5DCF788" modified="2006-07-11" version="1">MRQFPNDFLWGVATSAFQIEGATSADGRGESIWDRFAATPGKISDGSDGKVACDHYHRWREDVALMRWLGVKSYRFSVAWPRVLPTGRGAVNAAGLDFYSRLVDGLLDAGIEPFVTLYHWDLPQALQDLGGWPSRDTASAFVEYADVMSRKLGDRVKRWITHNEPWCISVLGYGNGEHAPGHKNWGEVLATAHHTLLSHGQAVPVIRANVKNAEVGITLNLSPAEPASPSPEDAEACRRHDGSFNRWFLDPLYGRGYPKDVVEDYVKDGRLASSALPFVRDGDMAAIAVPTDFLGINYYSRAIMRSDRIPESQNAPRTVHPEPERTDMDWEVYAPALTRMLVHLHTDYQPGPLYITENGCAYATGPSEDGKVHDDKRVAYLRSHLEASLEAIRQGVPLAGYFAWSLMDNFEWAFGYQKRFGMVYVDYDSQRRIPKDSAHLYKALVEKNGLDVELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY98</accession>
    <name>Q1CY98_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556433.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6502"/>
    <dbReference type="EnsemblBacteria" id="ABF92290">
        <property type="protein sequence ID" value="ABF92290"/>
        <property type="gene ID" value="MXAN_6502"/>
    </dbReference>
    <dbReference type="GeneID" id="41363710"/>
    <dbReference type="KEGG" id="mxa:MXAN_6502"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009659_0_0_7"/>
    <dbReference type="OMA" id="DAGCAYW"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="412"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="757"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="957" mass="101762" checksum="E7D065C2F63CBD34" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI0</accession>
    <name>Q1CYI0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556351.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6419"/>
    <dbReference type="EnsemblBacteria" id="ABF86900">
        <property type="protein sequence ID" value="ABF86900"/>
        <property type="gene ID" value="MXAN_6419"/>
    </dbReference>
    <dbReference type="GeneID" id="41363629"/>
    <dbReference type="KEGG" id="mxa:MXAN_6419"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_225281_0_0_7"/>
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    <dbReference type="OrthoDB" id="1315at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="18"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="2175"/>
            <end position="2208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="3182" mass="338833" checksum="D9C576CD82F002AB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYS8</accession>
    <name>Q1CYS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6320"/>
    <dbReference type="EnsemblBacteria" id="ABF89164">
        <property type="protein sequence ID" value="ABF89164"/>
        <property type="gene ID" value="MXAN_6320"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6320"/>
    <dbReference type="eggNOG" id="ENOG50319HW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088586_0_0_7"/>
    <dbReference type="OMA" id="LMACGAN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="30810" checksum="6EC88B71976AEE09" modified="2006-07-11" version="1">MCAWPPWPCMGGDMPRRTWMTLVVSGLVAGCAARPERYGFDSATSACRQNPAVCARMAGEEAVLPGTRALRVAASIGTAGDAALRLLKAEERDAIEEALEACVDDARSTVLIALFNGRSPTPEECRSEVTVDAQGRPVTLAMQLGTEMHKVALPCAHKWLSELRPGGYRLEPRYRYNPDSGRWEPMREEDVRALLRHGRGSELKGTLVPDVVIHTGSEMQVLAIYDFKFPCVTPNRPSNWPRYPKGHPHEGQQQDAMYQRALKPKQAPLQVTPRLGTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ21</accession>
    <name>Q1CZ21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6221"/>
    <dbReference type="EnsemblBacteria" id="ABF89489">
        <property type="protein sequence ID" value="ABF89489"/>
        <property type="gene ID" value="MXAN_6221"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6221"/>
    <dbReference type="HOGENOM" id="CLU_2991985_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="57" mass="6562" checksum="2BCACE6367D373DA" modified="2006-07-11" version="1">MPAFTQLKVKVVSFRYSNAWDPLEAMAQNSFPVASFMTSFPGFEYFDIYCFCSITKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ33</accession>
    <name>Q1CZ33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-C factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigC</name>
        <name evidence="6" type="ORF">MXAN_6209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556153.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CZ33"/>
    <dbReference type="STRING" id="246197.MXAN_6209"/>
    <dbReference type="EnsemblBacteria" id="ABF91722">
        <property type="protein sequence ID" value="ABF91722"/>
        <property type="gene ID" value="MXAN_6209"/>
    </dbReference>
    <dbReference type="GeneID" id="41363437"/>
    <dbReference type="KEGG" id="mxa:MXAN_6209"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_7"/>
    <dbReference type="OMA" id="HEQLGRW"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="33433" checksum="DB2D4E7832C7FA49" modified="2006-07-11" version="1">MQASNSFSSPDSLSTYLSEINQYPLLTQPQEQELSKRFRAGDLAAGHQLVTANLRFVVKVAYEYRSYGLKMSDLIQEANIGLMKAVQKFDPDKGIRLISYAVWWIRAYIQNCILKNWSLVKLGTTQAQRRLFFSLARTRRELEKMGAGDANVVNAEEIARKLNVKASEVREMEQRMGGRDLSLDAPMGEDGDATHLDFVESESVSAVDEVADRQQANLTRELVQRALRRLDPRERFIIEQRVMGDAEMTLSELGEHFGFSRERARQLEIRAKDKLKLALVTLMAEAGVDESTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA4</accession>
    <name>Q1CZA4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556082.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90048">
        <property type="protein sequence ID" value="ABF90048"/>
        <property type="gene ID" value="MXAN_6136"/>
    </dbReference>
    <dbReference type="GeneID" id="41363367"/>
    <dbReference type="KEGG" id="mxa:MXAN_6136"/>
    <dbReference type="eggNOG" id="ENOG50339VQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729227_0_0_7"/>
    <dbReference type="OMA" id="YADENMR"/>
    <dbReference type="OrthoDB" id="636574at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021815">
        <property type="entry name" value="DUF3396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11876">
        <property type="entry name" value="DUF3396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="42957" checksum="1A37E6BB36D12145" modified="2006-07-11" version="1">MNLTIDDHDIDADVTELQPELVEQARVVLACMRGAELLPQGVANVDVMHGPSLSNSEPVAPRHLLPAPGSHQAPYLLLQQHLERHGVFAITLFTDVSFLAIPEVLLRCQEMYFELCPRERLRFYADENMRKHRPVGPKTFGMLESSLRNPQDKDGIVALELKDGEHALDAPKHLFKVYGRDRDRRGDPDQLANSLCMTFAPEDGLARVRDMAALVRRIAEIFPYRSGCAGFGYQVSRYSSEVGESFAWQKSMRHPQMDIVRSLQDRHAVANNAGKTVNWLTLVCDELLRELGSPKNVEQTLEAPIEWTHLGAGVLFQLGASPGFIDRTRGETAPDYHRLHRLLRPLIERAREQSPWFATGSSDDQAERTDDWFRRFDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZK5</accession>
    <name>Q1CZK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555982.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6033"/>
    <dbReference type="EnsemblBacteria" id="ABF92419">
        <property type="protein sequence ID" value="ABF92419"/>
        <property type="gene ID" value="MXAN_6033"/>
    </dbReference>
    <dbReference type="GeneID" id="41363271"/>
    <dbReference type="KEGG" id="mxa:MXAN_6033"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="IILDYMM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14077" checksum="CE6DF00EAA9E2887" modified="2006-07-11" version="1">MSTHSTNVLLVDDSPTVRNIVKIYLMNLKVSTVEADDATRGLQILRLVPVSLVIADINMPGMDGITFVKEVRASAMPQVRSVPILLLTAEKNVDLRQRGTEAGANAFIQKPVSHHELTETVRQFLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZT0</accession>
    <name>Q1CZT0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5956"/>
    <dbReference type="EnsemblBacteria" id="ABF89333">
        <property type="protein sequence ID" value="ABF89333"/>
        <property type="gene ID" value="MXAN_5956"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5956"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852125_0_0_7"/>
    <dbReference type="OMA" id="FHWLCRK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="36959" checksum="8BECBBA8FBFB7DF8" modified="2006-07-11" version="1">MNRSRRLVVEALGCGLLVVALEGAHHGAEHLGVSATDGRLFMSLGAGAVLACLAYVLQPLTGAHFNPALTFADALEDGTPWRDVPLYVLAQVGGAVAGRWVAHVMCHEPMLVGASEPTASLAQFVTELVSTFGLLVMVRGCVRNRPTAIPLVVAGYLAATVWFTDSRALANPALILARAFSTRPSAMHSMDVESIIAAQLLGAALAVLLFRWLQRTPRMKQARVWPIVFECSRPEVAQQAVGIFNHLASPQRARATTQWHAGDDTDLPPLIVRLVLAGEPTEPSHPDGVSWQLRVPADAVTTEEPRLRAELRAPIRQLLRNRGWLRLHAVGDAAREGPSGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0G9</accession>
    <name>Q1D0G9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555668.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5716"/>
    <dbReference type="EnsemblBacteria" id="ABF86624">
        <property type="protein sequence ID" value="ABF86624"/>
        <property type="gene ID" value="MXAN_5716"/>
    </dbReference>
    <dbReference type="GeneID" id="41362961"/>
    <dbReference type="KEGG" id="mxa:MXAN_5716"/>
    <dbReference type="HOGENOM" id="CLU_1174416_0_0_7"/>
    <dbReference type="OMA" id="SFNWGRE"/>
    <dbReference type="OrthoDB" id="1140585at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25770" checksum="73341043856AA3C0" modified="2006-07-11" version="1">MSLETQHRTHRPPSSAALAERYRVKRLLPGVLLACFLALPATALAQRGQGWSVLAGDTLGRGNTAFHGQIGWPGISLGLLHGGSERFDIGGKFSFNWGREGWVRYTDPGIKLQAWMRLQLVKERNFSLALTFQPGPFFYFNRHDTDVGLALPVGVVVGIPAGSAVMVNLGLDIPFHVYFGEGIGPVFPVLVGGGLEYFVNRQLGVTFNVRLGPAVIPDIDDTEFTLEALFGVAYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R6</accession>
    <name>Q1D0R6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aha1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555572.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5618"/>
    <dbReference type="EnsemblBacteria" id="ABF87953">
        <property type="protein sequence ID" value="ABF87953"/>
        <property type="gene ID" value="MXAN_5618"/>
    </dbReference>
    <dbReference type="GeneID" id="41362864"/>
    <dbReference type="KEGG" id="mxa:MXAN_5618"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23461" checksum="0A4BDD9CD5D01B30" modified="2006-07-11" version="1">MIDVKRYLGAVVREVESREHEGKPARVVVATRDYDTTVEDLWDALTNPERIPRWFLPVSGDLKLGGRYELKGNASGSVTRCEAPRHLGLTWEFGGSVSWLEVILANAPGGGTRLRLEHMAHVSPFWDDYGPGATGVGWELGLMGLGMHLESGGAAVDSAAVESWTTSDEGKAFITASSEGWGQADVTRGEDAAAAKARAARTTAFYTGAPPPDVRHPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0U8</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">MXAN_5586</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="EnsemblBacteria" id="ABF87338">
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        <property type="gene ID" value="MXAN_5586"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_452575_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="603" mass="64941" checksum="A9EB08AAC04C6259" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D190</accession>
    <name>Q1D190_MYXXD</name>
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            <fullName evidence="1">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_5440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01433">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="316"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="595" mass="65642" checksum="AEA3FBC222CD15F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B8</accession>
    <name>Q1D1B8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">MXAN_5408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5408"/>
    <dbReference type="EnsemblBacteria" id="ABF86479">
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        <property type="gene ID" value="MXAN_5408"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5408"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263145_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188114" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="295"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="411"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1280" mass="134947" checksum="35DA241CC0A3CEF2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D212</accession>
    <name>Q1D212_MYXXD</name>
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        <submittedName>
            <fullName evidence="9">AzlC family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">MXAN_5158</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5158"/>
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        <property type="family name" value="the branched chain amino acid exporter (liv-e) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88645">
        <property type="protein sequence ID" value="ABF88645"/>
        <property type="gene ID" value="MXAN_5158"/>
    </dbReference>
    <dbReference type="GeneID" id="41362440"/>
    <dbReference type="KEGG" id="mxa:MXAN_5158"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065777_0_1_7"/>
    <dbReference type="OMA" id="GSHIMND"/>
    <dbReference type="OrthoDB" id="1866750at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="24965" checksum="D1557A5E155B8537" modified="2006-07-11" version="1">MRAMAMGHVDRSLVRDVAAIAAASSVIGASFGAISVASGLSVWVASAMSVFVFAGGSQFMAVGVVAGGGSPVAAVIAGLLLNARHLPFGLVISDVLGRHWLVRLIGTHLMVDESVAFALAQSTPERRKAAYWLCGGALFVAWNVGVLVGALAGTALGSPEAMGLDAAFPAGLLALLLPSLTAPAKPPNAEPGTAEGEVETARAHEARAAAARARWVAGGAALIALATTPILPTGVPVLLSLLALGLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D232</accession>
    <name>Q1D232_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminopeptidase N</fullName>
            <ecNumber evidence="3">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_5137</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555110.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5137"/>
    <dbReference type="MEROPS" id="M01.A26"/>
    <dbReference type="EnsemblBacteria" id="ABF86152">
        <property type="protein sequence ID" value="ABF86152"/>
        <property type="gene ID" value="MXAN_5137"/>
    </dbReference>
    <dbReference type="GeneID" id="41362421"/>
    <dbReference type="KEGG" id="mxa:MXAN_5137"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_2_7"/>
    <dbReference type="OMA" id="YHPICRQ"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="PTHR45726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Leuk-A4-hydro_C" evidence="13">
        <location>
            <begin position="448"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="256"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="537"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF86152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="584" mass="65735" checksum="8C240ED77AF3D646" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D247</accession>
    <name>Q1D247_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermine/spermidine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555096.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5122"/>
    <dbReference type="EnsemblBacteria" id="ABF90533">
        <property type="protein sequence ID" value="ABF90533"/>
        <property type="gene ID" value="MXAN_5122"/>
    </dbReference>
    <dbReference type="GeneID" id="41362406"/>
    <dbReference type="KEGG" id="mxa:MXAN_5122"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010122_1_0_7"/>
    <dbReference type="OMA" id="IFMGGMA"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="6">
        <location>
            <begin position="463"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="958" mass="102510" checksum="E80BB11E17409CC4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D273</accession>
    <name>Q1D273_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555070.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5096"/>
    <dbReference type="EnsemblBacteria" id="ABF93113">
        <property type="protein sequence ID" value="ABF93113"/>
        <property type="gene ID" value="MXAN_5096"/>
    </dbReference>
    <dbReference type="GeneID" id="41362380"/>
    <dbReference type="KEGG" id="mxa:MXAN_5096"/>
    <dbReference type="eggNOG" id="COG2311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039610_0_0_7"/>
    <dbReference type="OMA" id="GLIHQMF"/>
    <dbReference type="OrthoDB" id="1742337at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="442" mass="48801" checksum="89389144D77C4B2D" modified="2006-07-11" version="1">MSQSGSPVADDLPVARPVDASERVVLLDALRGFALWGVFVSNSLMWLSGRAFMPREAASALDAPLLEQVIGSIYQLFVTQKFISIFSFLFGLGFALQFSRAESRGVSAAPLYRRRLLMLFGIGLAHALLLWTGDILHTYAMVGFLLMAFRARSNRTVLFWALGLVTVMPFLVPAAIRYTPILLHGAEAAAEAAKASHARDMALRADTLVALSSESFWTAQVGNARFFLENLGGGFRRVLWMSLILGRFLLGLLAGRLLLLQDVERHRALLRRILGWGLSVGLVLNGGGLLLFRLRKAGVLEWDPKGPWMMIVNGFQEPGYIAMGAAYVAAFALLFQRERWSRWLGVLTPVGRMALTNYLMQSAVSIWIYSGWGLGFIGKLPASRIVVICCVIFAAQVVFSRLWLARFRFGPAEWLWRSLTYGRVQPMRRLAGDGGVPGVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F4</accession>
    <name>Q1D2F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87982">
        <property type="protein sequence ID" value="ABF87982"/>
        <property type="gene ID" value="MXAN_5014"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5014"/>
    <dbReference type="HOGENOM" id="CLU_3101221_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="51" mass="5572" checksum="432D94EDA920D72D" modified="2006-07-11" version="1">MAAVIRMLDELLAIIVQSMSAAGKMSFMAGVLVPEEDRVKYSAVTGLRWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M8</accession>
    <name>Q1D2M8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554917.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4939"/>
    <dbReference type="ESTHER" id="myxxd-q1d2m8">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91570">
        <property type="protein sequence ID" value="ABF91570"/>
        <property type="gene ID" value="MXAN_4939"/>
    </dbReference>
    <dbReference type="GeneID" id="41362224"/>
    <dbReference type="KEGG" id="mxa:MXAN_4939"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791854_0_0_7"/>
    <dbReference type="OMA" id="VVHCQGS"/>
    <dbReference type="OrthoDB" id="891360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="350" mass="38961" checksum="31C6059972FA36BF" modified="2006-07-11" version="1">MPAEPHSTASYSEEVIPFLAGDGRALHLIRIRGDAKPNKGPVVLVHGAGVRSNIFRAPVRQTLVDALVADGYDVWLENWRASIDVEPSEWTLDQAAVLDHPAAIRTVVRESGHDTVKAIIHCQGSCSFAMAAVSGLLPEVDVIVTNAVSLHPVVPHAAALKLKLAVAPVARLTPYLDPQWAFGPPTLTARLLTLLVRAFHHECTNLVCRWSSFTYGVGFPVLWRHENLNSETHDWLQQEFAKVPLTFFHQMSECVRAGHLVPVEGFQALPEDLAVREPETDARFVFLAGEQNRCFLSESQRRSFEHLERFRPGYHMLHLVPGYGHLDMFMGQDASRDVFPLILAELDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R0</accession>
    <name>Q1D2R0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4906"/>
    <dbReference type="EnsemblBacteria" id="ABF88786">
        <property type="protein sequence ID" value="ABF88786"/>
        <property type="gene ID" value="MXAN_4906"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4906"/>
    <dbReference type="HOGENOM" id="CLU_2494672_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9673" checksum="C4B4427FC4840B41" modified="2006-07-11" version="1">MPLCTASGKGGRSQEIPWTLGREHEKRAALTALSGRFHITYTESFHMPAQKGNRSKKKVANRAKGRKAQLKRRRSRAKKGQSNNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R9</accession>
    <name>Q1D2R9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4897"/>
    <dbReference type="EnsemblBacteria" id="ABF91946">
        <property type="protein sequence ID" value="ABF91946"/>
        <property type="gene ID" value="MXAN_4897"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4897"/>
    <dbReference type="eggNOG" id="ENOG5033G41">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738549_0_0_7"/>
    <dbReference type="OMA" id="AQFFRDW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="16273" checksum="583EF3D7FCF3EC06" modified="2006-07-11" version="1">MHSFLSVALHSSTGGGMAGEERQTGTRDEQYNLISVLYHLLKGASTSEAYIRDAEEIGDPELAQFFRDWQEEQRNLAERAKNLLGARMAGVSRAGTGRKRSAQEGRRGAGSVEKQPTNASVASGGNDTTRDAVDEELLETFPASDPPGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D391</accession>
    <name>Q1D391_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554707.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4720"/>
    <dbReference type="EnsemblBacteria" id="ABF86262">
        <property type="protein sequence ID" value="ABF86262"/>
        <property type="gene ID" value="MXAN_4720"/>
    </dbReference>
    <dbReference type="GeneID" id="41362019"/>
    <dbReference type="KEGG" id="mxa:MXAN_4720"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_0_0_7"/>
    <dbReference type="OMA" id="LFVIMDP"/>
    <dbReference type="OrthoDB" id="1323133at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="21916" checksum="E8D5E80D245E7E88" modified="2006-07-11" version="1">MPEYASLFLVSLSAIFFVVDPIGVVPLFLAMTAGDSQEKVRRTAMRACLVACGMMLFFALFGGVIFKVFGVSLGAFRVAGGILLLITALDMLRARPAETRTTPSEEQEGVVKEDVAIVPLAIPLLAGPGAIATAMVLMAKGDTLVSAIPVLAAVVLTFVASYFILRASGLIQRVLRQSGVAIVERVMGLILAAIAVQFIADGGKELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K8</accession>
    <name>Q1D3K8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554592.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4597"/>
    <dbReference type="EnsemblBacteria" id="ABF93055">
        <property type="protein sequence ID" value="ABF93055"/>
        <property type="gene ID" value="MXAN_4597"/>
    </dbReference>
    <dbReference type="GeneID" id="41361897"/>
    <dbReference type="KEGG" id="mxa:MXAN_4597"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021907_0_0_7"/>
    <dbReference type="OMA" id="CKFCSFP"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031003">
        <property type="entry name" value="BcpD_PhpK_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04479">
        <property type="entry name" value="bcpD_PhpK_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="250"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="559" mass="63132" checksum="F9E32EC2ADE85AA9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3S9</accession>
    <name>Q1D3S9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554521.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4526"/>
    <dbReference type="EnsemblBacteria" id="ABF89696">
        <property type="protein sequence ID" value="ABF89696"/>
        <property type="gene ID" value="MXAN_4526"/>
    </dbReference>
    <dbReference type="GeneID" id="41361828"/>
    <dbReference type="KEGG" id="mxa:MXAN_4526"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_2_7"/>
    <dbReference type="OMA" id="PDFEWAI"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
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        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="PKS_assoc"/>
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        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
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        <property type="entry name" value="PKS_dehydratase"/>
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    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
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    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2043"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2146" mass="229375" checksum="477A6F084FA3E71C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4V2</accession>
    <name>Q1D4V2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ald</name>
        <name evidence="11" type="ORF">MXAN_4146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554149.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4146"/>
    <dbReference type="EnsemblBacteria" id="ABF89151">
        <property type="protein sequence ID" value="ABF89151"/>
        <property type="gene ID" value="MXAN_4146"/>
    </dbReference>
    <dbReference type="GeneID" id="41361465"/>
    <dbReference type="KEGG" id="mxa:MXAN_4146"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_7"/>
    <dbReference type="OMA" id="HFLTKQA"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="39347" checksum="850F0D38323B0CA4" modified="2006-07-11" version="1">MIVGVPKEIKTREYRVGMVPAGAAALIAAGHTVLIETNAGVGSGIPDSEYQRVGAQIISTADEVWKRSEMIIKVKEPIAPEYARIQPGQIIYTYFHLAGVDPELTKTLLQKKAAAVAYETLQPDDGSLPLLKPMSEVAGKMAIQVGAKCLERAHGGKGILLGGVPGVRRGRVTVIGGGVVGLCAAKVAVGMGAEVTIIDVNMERLTYLDDVFLGRVGVLASDSESISRSVREADLVVGAVLIPGRKAPKLVSEALISEMSPGSVVVDVAVDQGGCIETCKPTTHDNPTFEVHGVVHYCVANMPGAVPQTSTYALTNVTRPYSLRIANVGLAAAVKEDRALARAMNTYNGHVTYEAVAKDMGYAYMPIADALAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Y6</accession>
    <name>Q1D4Y6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4109"/>
    <dbReference type="EnsemblBacteria" id="ABF89216">
        <property type="protein sequence ID" value="ABF89216"/>
        <property type="gene ID" value="MXAN_4109"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4109"/>
    <dbReference type="eggNOG" id="ENOG502ZA0Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583722_0_0_7"/>
    <dbReference type="OMA" id="IVYETCA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011447">
        <property type="entry name" value="DUF1552"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07586">
        <property type="entry name" value="HXXSHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="468" mass="49628" checksum="E02937EBCC2384CA" modified="2006-07-11" version="1">MTAMFSRRTVLKGMAAGLFAPYFHDVYAQSSALPARLVLVLECNGVYPRALLSTGTRAALGGRANTSDRIFWDAYKDTPMVREGDNLASAISLGPLAASSGNIDLVNRSAVLLGLSNLIAGGGHSSGTGGLSCAVNGAGATFDAVIAPRLRRGAPFDVLRLGTSSARVSIVYETCALGPRKPAGIIVNPSLAFDSTFGSLLGGSTNGRDRKMLFDFALADSRKALAEFSGNSNERLKLERYVSSLESLRTREDQLEGMADRVRPYLPPAPKDNPLITGAGSPPDSLKWFEAQFQIATASLLGGLTNTVVLATGTSGFDVAYGPDVTDIPRHSLQHGLDAGQNWDRVAEVTRRHVQLVANLARTLATTPEVGASGSMLDHTAIVFMSDNGEQHHSTSREWPKLVVGGNALGLKTDGRTVVYPKYDAARNRQVSNLFNTLGHAFGDADFNTFGQEGSTRIAPGPLSELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D512</accession>
    <name>Q1D512_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4083"/>
    <dbReference type="EnsemblBacteria" id="ABF87947">
        <property type="protein sequence ID" value="ABF87947"/>
        <property type="gene ID" value="MXAN_4083"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4083"/>
    <dbReference type="HOGENOM" id="CLU_3382850_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="33" mass="3671" checksum="EAD03215396A907B" modified="2006-07-11" version="1">MRPVFFNALLCARTFAPAADVCLAPRHEVLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D515</accession>
    <name>Q1D515_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mchD</name>
        <name evidence="2" type="ORF">MXAN_4080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria.</title>
            <authorList>
                <person name="Burgard C."/>
                <person name="Zaburannyi N."/>
                <person name="Nadmid S."/>
                <person name="Maier J."/>
                <person name="Jenke-Kodama H."/>
                <person name="Luxenburger E."/>
                <person name="Bernauer H.S."/>
                <person name="Wenzel S.C."/>
            </authorList>
            <dbReference type="PubMed" id="28128551"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX622595">
        <property type="protein sequence ID" value="APZ78770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554087.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4080"/>
    <dbReference type="EnsemblBacteria" id="ABF90624">
        <property type="protein sequence ID" value="ABF90624"/>
        <property type="gene ID" value="MXAN_4080"/>
    </dbReference>
    <dbReference type="GeneID" id="41361410"/>
    <dbReference type="KEGG" id="mxa:MXAN_4080"/>
    <dbReference type="eggNOG" id="COG5528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127159_0_1_7"/>
    <dbReference type="OMA" id="TITAYWK"/>
    <dbReference type="OrthoDB" id="1724614at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018729">
        <property type="entry name" value="DUF2269_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10027">
        <property type="entry name" value="DUF2269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="APZ78770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17250" checksum="5F888997193ED6A2" modified="2006-07-11" version="1">MNVHNVLKLLHLIAVVVFLGDIVVTAVWRLLADRTREPRVIVYALRLVQFTDKYLLVPSVFALAATGMLRAHLQDIPLWTNPALAAGQVCFMLCGIVWQLTLRPIQARQLAMAEAFGDTGASFDDYLLLTQKWFRWGILAMALAFGSMALMVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D593</accession>
    <name>Q1D593_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4000"/>
    <dbReference type="EnsemblBacteria" id="ABF92643">
        <property type="protein sequence ID" value="ABF92643"/>
        <property type="gene ID" value="MXAN_4000"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4000"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_15_7"/>
    <dbReference type="OMA" id="WMKREAG"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="PKS_TE"/>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
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    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2050"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3117"/>
            <end position="3192"/>
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    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4165"/>
            <end position="4240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1010"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2085"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3152"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="4528" mass="495222" checksum="9138DAEEC1A84A65" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U3</accession>
    <name>Q1D5U3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553810.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3798"/>
    <dbReference type="EnsemblBacteria" id="ABF88902">
        <property type="protein sequence ID" value="ABF88902"/>
        <property type="gene ID" value="MXAN_3798"/>
    </dbReference>
    <dbReference type="GeneID" id="41361129"/>
    <dbReference type="KEGG" id="mxa:MXAN_3798"/>
    <dbReference type="HOGENOM" id="CLU_1325183_0_0_7"/>
    <dbReference type="OMA" id="RVYAFPD"/>
    <dbReference type="OrthoDB" id="1303350at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188292" evidence="1">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="25437" checksum="118CA7C4E2D7E64A" modified="2006-07-11" version="1">MKGLAAGGLLACLLAAVPAQASDEGEDDDGRAPVLVSWKRSLCLYTGCFLEPLVPDVRYEWGPGAQEGWVLSWPIHPWALPPLDVPGPTLVVSPFLEPQLRLGRTAFRMLAGARVYAFPDAARFGVLAEGAGLWGRDGSGGVAGLGLSYDFIERHPDTVPWTLSVVVRRAWTGEGNRLDVSLDVTVPLNMFWGTPGESRVSGDRTVSHRHATARFRARAASSLFQREAPHIMEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X6</accession>
    <name>Q1D5X6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">era</name>
        <name evidence="12" type="ORF">MXAN_3765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553778.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3765"/>
    <dbReference type="EnsemblBacteria" id="ABF92468">
        <property type="protein sequence ID" value="ABF92468"/>
        <property type="gene ID" value="MXAN_3765"/>
    </dbReference>
    <dbReference type="GeneID" id="41361097"/>
    <dbReference type="KEGG" id="mxa:MXAN_3765"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_7"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF92468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="35049" checksum="DFA27B8BFF68CE2B" modified="2006-07-11" version="1">MAPPKTHRSGFAALIGRPNVGKSTLLNALTGEKIAIVSPKPQTTRNRILGVVTRPEGQVAFIDTPGIHQAKGELNRYMVEVALQAAEEVDLVLFLIEPPASEKPEVSPGNRAILDRLQKIGKPTFLVINKIDSVPKSQLLPLIDLYRQEFPFAEVVPISAREKDGVERLFHTVLGHLPEGENVFDEDMLTDQQERALVAEYIREQVLRHCRQEIPYSTAVVVDIFDESEREPRPGTPPNQLGGLIRIAASIFVERDSQKAIIIGKQGQMLKTIGTDARKSVQRLLGAHVYLDLRVRVEPRWSERPEGLKKLGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D618</accession>
    <name>Q1D618_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mce family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553736.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3719"/>
    <dbReference type="EnsemblBacteria" id="ABF92221">
        <property type="protein sequence ID" value="ABF92221"/>
        <property type="gene ID" value="MXAN_3719"/>
    </dbReference>
    <dbReference type="GeneID" id="41361052"/>
    <dbReference type="KEGG" id="mxa:MXAN_3719"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034188_0_0_7"/>
    <dbReference type="OMA" id="PRPDKYY"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="509" mass="55695" checksum="2064EE5F534F6A5A" modified="2006-07-11" version="1">MKKLVTPFRVGLLVIAAGAFFVTFVLFARKGGLSDSESTRVWAYFRDASGLAVRGRVQIAGIPVGEIDDISLEGTRAKVWLKIRNDVDLREDAVVTKRSESLLGDYLLDLNPGTESAPHLGSGGQIRRVVDTQGMEAVFESLSQITADIQEVTGALREVLGGERGAGSLQRIVENLVRLSDSVDSTVRRNADRLDTIVGNVEAISADVRGITQGNQAEITRIIDNIEFITRDVRQVLGSVKNIVGTGEGDVKETVASLKETLKKLDGTLGNLEEITRKVRDGEGAAGVLLADEAVGRELRETVQDVSRFTSRLTDLQAEIGIQSTYLAAQGNSKNVFSVRLIPKPDKYYLLELVDDPRGSVTTEVLQTNPPSEGDPVVQTRKVTKESLKVSAQFAKRWYFTTLRVGLIESTGGVGADLHFFNDALRFQVDAFNFADDELRYPRLRASLRAQPLDHLYLIAGMDDMLNAQQRDLATRRLVAGRDFFVGGGLFFTDDDLKAILTLTGIPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D632</accession>
    <name>Q1D632_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3705"/>
    <dbReference type="EnsemblBacteria" id="ABF92797">
        <property type="protein sequence ID" value="ABF92797"/>
        <property type="gene ID" value="MXAN_3705"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3705"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017737_1_0_7"/>
    <dbReference type="OMA" id="KDRFFRA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="563"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="710" mass="77177" checksum="8895BF98AE46B606" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D634</accession>
    <name>Q1D634_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553720.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3703"/>
    <dbReference type="EnsemblBacteria" id="ABF90452">
        <property type="protein sequence ID" value="ABF90452"/>
        <property type="gene ID" value="MXAN_3703"/>
    </dbReference>
    <dbReference type="GeneID" id="41361036"/>
    <dbReference type="KEGG" id="mxa:MXAN_3703"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_7"/>
    <dbReference type="OMA" id="FFATWCF"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="171" mass="18206" checksum="03C6294EF3D90FEF" modified="2006-07-11" version="1">MSRVLLRGAVVALVALAGCRGTRPVDAGYAFLNALALPSVGPTPHDVRALDGKVVLVSFFATWCFPCLAEMPTLEALQKDYGPRGFQVVAVGMDLEGEKVLAPFADHYALRYPVLVANQAMIEGHSAFGAIQGLPTTVLLDRRGRAVAGWHGVESHADMAKAVEKLLAQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N8</accession>
    <name>Q1D6N8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3490"/>
    <dbReference type="EnsemblBacteria" id="ABF88664">
        <property type="protein sequence ID" value="ABF88664"/>
        <property type="gene ID" value="MXAN_3490"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3490"/>
    <dbReference type="HOGENOM" id="CLU_1784801_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15642" checksum="41B5AE8C9E5F2BA3" modified="2006-07-11" version="1">MKGIRHGAALFPRGRLADRPNGPVRIPTVRSPQVPLTRSLAILRTHHLLTKGEFMRTGIMVGLLAVGLMTGCGGIEEEAAAGLETEAQAIPCRDITGRDYVITYYAEPAKVTKVGELLCGCSTPETVLNGTKTSYYEKVYGCFAM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D766</accession>
    <name>RS17_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">MXAN_3308</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D766"/>
    <dbReference type="SMR" id="Q1D766"/>
    <dbReference type="STRING" id="246197.MXAN_3308"/>
    <dbReference type="EnsemblBacteria" id="ABF90741">
        <property type="protein sequence ID" value="ABF90741"/>
        <property type="gene ID" value="MXAN_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3308"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_7"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000255687" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="108" mass="12475" checksum="BAE91C37B67728DF" modified="2006-07-11" version="1">MREKMAEATETQASETSTRGRPKTRVGIVTSNKMQKTVVVTVQRRAPHPKYGKIMSLREKYKAHVEDHDYPKKITINEGDRVRIAETKPASKDKRWRVVEVLEKSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H7</accession>
    <name>Q1D7H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553242.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3195"/>
    <dbReference type="EnsemblBacteria" id="ABF87135">
        <property type="protein sequence ID" value="ABF87135"/>
        <property type="gene ID" value="MXAN_3195"/>
    </dbReference>
    <dbReference type="GeneID" id="41360550"/>
    <dbReference type="KEGG" id="mxa:MXAN_3195"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337652_0_0_7"/>
    <dbReference type="OMA" id="RELKHGR"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045427">
        <property type="entry name" value="MoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20030">
        <property type="entry name" value="bpMoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bpMoxR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="843" mass="92419" checksum="1BDDF69072DCEF73" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7N1</accession>
    <name>Q1D7N1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553189.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3139"/>
    <dbReference type="EnsemblBacteria" id="ABF86156">
        <property type="protein sequence ID" value="ABF86156"/>
        <property type="gene ID" value="MXAN_3139"/>
    </dbReference>
    <dbReference type="GeneID" id="41360498"/>
    <dbReference type="KEGG" id="mxa:MXAN_3139"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658598_0_0_7"/>
    <dbReference type="OMA" id="QPVVAHY"/>
    <dbReference type="OrthoDB" id="321589at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="46569" checksum="EB8C0D0DC80FC78F" modified="2006-07-11" version="1">MKVPEMLENLPGVGPLIGRIAHGPEGALPRRETTVTLPDFAAVSLPNTERALGDGRTLVIRNPAVRSPRGPGLTVMTYNILLGGHRRQALLDYFDNLEARGRLPDVLGLQEANVPIAVLLAERYGFHLAYQGHDGGPGARLMNGKAFLTRHPLVDAAHFTYATPDAERDAAIMRRGGDPCEIPEDRGALYVRLEVEGHPVVLYNVHHTLGDSGINARNLRQLNALLQHREVMHAVALGDFNANTAIKSGGSWLMAHLRTYDDTDTVEEYEVRYGEPHASVGDEGVGNIADPRLRHELHVLEQSLPETIAHATTAQVRLPDGSLMTPKQACAELRSGRVQRGSEQWLRLQDIADSATLTSLPDENGVVPATGKRFDNLYASPGLVPRLFEVDRSTESSDHQPVVAHYDVRTPGLKDGKPAPGTVQRPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7T4</accession>
    <name>RECO_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recO</name>
        <name type="ordered locus">MXAN_3086</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553136.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7T4"/>
    <dbReference type="SMR" id="Q1D7T4"/>
    <dbReference type="STRING" id="246197.MXAN_3086"/>
    <dbReference type="EnsemblBacteria" id="ABF89675">
        <property type="protein sequence ID" value="ABF89675"/>
        <property type="gene ID" value="MXAN_3086"/>
    </dbReference>
    <dbReference type="GeneID" id="41360448"/>
    <dbReference type="KEGG" id="mxa:MXAN_3086"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_2_0_7"/>
    <dbReference type="OMA" id="LCTQSET"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264825" description="DNA repair protein RecO">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <sequence length="244" mass="26650" checksum="4B18534DE7E21377" modified="2006-07-11" version="1">MERYDDDALVLSSVDYGESDRLVTLLTREHGKLTAFAAGARKSKRRFAGALEPFMRLRVHIVETRGSTVRLDGTDIVAGFYAAREDLSLIARALYAVELCRELTRDHEPQPELFALLESYLTRLDAKEAGPTSLLAFELSALAHAGLMPRFDSCSLCGGAPGERPRFDQAHGGAVCEPCGVRARESVAVPVALLSGLRALQEGARTPLPPELRARARGLLNVFIAHHLGRRLKSVDFMAQVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W5</accession>
    <name>Q1D7W5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">asd</name>
        <name evidence="10" type="ORF">MXAN_3050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553105.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3050"/>
    <dbReference type="EnsemblBacteria" id="ABF90676">
        <property type="protein sequence ID" value="ABF90676"/>
        <property type="gene ID" value="MXAN_3050"/>
    </dbReference>
    <dbReference type="GeneID" id="41360412"/>
    <dbReference type="KEGG" id="mxa:MXAN_3050"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_7"/>
    <dbReference type="OMA" id="WPEMVDN"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="9">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="362" mass="38715" checksum="C00A73CFDE118548" modified="2006-07-11" version="1">MARLRAALIGATGLAGQQFIAALKNHPSIELTGLAASPRSAGKTYAEALKTASGMTAWFVPEPLPAELAGMKVVAGDALEAKDYDLVFSAVEADVARELEPRLAKDIPVFSAASAFRYEDDVPLLIPPVNAAHAPLIREQQRRRGWKGFIVPIPNCTTTGLAVTLAPLVERFGVKAVLMTSLQAMSGAGRSPGVIGMDILDNVIPYIPKEEHKVEVETKKILGALRPAGDGLTPHDVRVSCTCTRVAVMEGHTESVFVSLDKKATVAEVTQALREWKGAELARNLPSAAPRWIEVLDDPFRPQPRLDRDTHGGMATTVGRIREDGVLENGFKYVLVSHNTKMGAARGAILVAELLLAQGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D822</accession>
    <name>Q1D822_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2992"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86636">
        <property type="protein sequence ID" value="ABF86636"/>
        <property type="gene ID" value="MXAN_2992"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2992"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304001_0_0_7"/>
    <dbReference type="OMA" id="PLRMMYL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1030" mass="109152" checksum="5F3027C5CEEF5237" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D835</accession>
    <name>Q1D835_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2979"/>
    <dbReference type="EnsemblBacteria" id="ABF90800">
        <property type="protein sequence ID" value="ABF90800"/>
        <property type="gene ID" value="MXAN_2979"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2979"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648636_0_0_7"/>
    <dbReference type="OMA" id="CEPRVNQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="44444" checksum="93D9177C3165C64D" modified="2006-07-11" version="1">MGTEIMPPQASLIPREEGGLAHGDRNGPRNGRIGSNFCRASRAPQGTALEQSYSASKSSNLLGIPARVFGNDKDGGRRGQGILARLQGRRGTSMMERARIHPHMPPSLLNKGLATVLSVASGLAWAGPPTVSSSYQGDSYGVVSLRMQGDQLVGVATGGPCGFEPDTEVLSGEFQDNVLVGQVLLCQLGPHCEPRVNQPALVVFNPDDGVMTALFRLKDGCRSPVLKNDSLLLLRPLSRDAEAVAPGRAASATAAVAASATADGANSSAAQVAAGLGRQGEVSPLEEGQRQLAAGNAGVAQRHFELALSKDPRSAAAVVGLGASQLMLNDVSRAVKTLEAGRGLGRADVHLWLAYAYQREGNRNRSRESLRKAFEQGWMPAGRAAEAVAEQALREDIETLMQQQRTRKRGPVRPSAGAGNTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8J7</accession>
    <name>Q1D8J7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552876.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2809"/>
    <dbReference type="EnsemblBacteria" id="ABF88542">
        <property type="protein sequence ID" value="ABF88542"/>
        <property type="gene ID" value="MXAN_2809"/>
    </dbReference>
    <dbReference type="GeneID" id="41360185"/>
    <dbReference type="KEGG" id="mxa:MXAN_2809"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_7"/>
    <dbReference type="OMA" id="GTPPRWC"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42390" checksum="54C1F14D0CA8585B" modified="2006-07-11" version="1">MRGEPIVLSTYLSRDAARRLRHGAPWLRREDIVSMEGTPQPGEPVQLRDEDGSVLGLGDVDLEASYAVRRLGQPDEAVEGLIPRHLRHAFERRARLVDDPRFCRVVNDDGDGLPGLIVDRYDTHFVVQTLTRAMDARHEELTRALVEVAGAGAVLLRNDTLRRKALGLPTQRPHVLYGTPPRWCRLLEMGARFTVDLTYGQGTGYAYDQREVRRFVARMAQGSRVLDASCNVGGLFVHAGVHGARHILAFDADADAADLARENAEANGLLGRVMVETGKPLQVLRAVRDTFDLVLLDTPAVATGEEFVELLRHALRRTRHGGWLMVTGYHPPLPQDGFDDLVATACEGEARIATRLARPGLPPDHPTLAGSHGAEHLHAMALEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9G8</accession>
    <name>Q1D9G8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552557.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2486"/>
    <dbReference type="EnsemblBacteria" id="ABF92633">
        <property type="protein sequence ID" value="ABF92633"/>
        <property type="gene ID" value="MXAN_2486"/>
    </dbReference>
    <dbReference type="GeneID" id="41359868"/>
    <dbReference type="KEGG" id="mxa:MXAN_2486"/>
    <dbReference type="HOGENOM" id="CLU_1110862_0_0_7"/>
    <dbReference type="OMA" id="QGSDFAM"/>
    <dbReference type="OrthoDB" id="1290689at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188015" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="23604" checksum="3EB03E15EC6D72A6" modified="2006-07-11" version="1">MKRPLLLCTLLAGTAFAAKERATFRYAAPPDGERPVIVNAVIGPQGSDFAMRLRFDKVPWGDECKSRCANATLLLDTDNSKQTGLRLATKNAPGNGADVAVVIQGVRDYAKQEGAPPVSWLRVKVRLLGSEASSVDDGELLAEFNHRQDPERLHVDGETIYLLVDATSAALPSARKARVVYQPPGAKPLQATIPGMIGGGSGKGVRIFKDGSWGKARDATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I0</accession>
    <name>Q1D9I0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2473"/>
    <dbReference type="EnsemblBacteria" id="ABF90765">
        <property type="protein sequence ID" value="ABF90765"/>
        <property type="gene ID" value="MXAN_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2473"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123303_0_0_7"/>
    <dbReference type="OMA" id="GRNACEG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="17254" checksum="12E639EEAC30E5E0" modified="2006-07-11" version="1">MDERLWLPPLPSEPEVLIECPRFSFVKRRADGAVDFVSPLPCPYNYGSIPGLASDEGDPLDAVVMGPRLALGQRLRVPVVGVIGFVDAGRGDPKVVCAAAPLTAAERAGLERFFRVYALFKQVLHRVRGNVPDTRFMGWLPLPVPAPDAAPEATARRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I2</accession>
    <name>Q1D9I2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552543.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2471"/>
    <dbReference type="EnsemblBacteria" id="ABF86026">
        <property type="protein sequence ID" value="ABF86026"/>
        <property type="gene ID" value="MXAN_2471"/>
    </dbReference>
    <dbReference type="GeneID" id="41359854"/>
    <dbReference type="KEGG" id="mxa:MXAN_2471"/>
    <dbReference type="eggNOG" id="COG4235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514509_0_0_7"/>
    <dbReference type="OMA" id="HELTHHY"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="507" mass="56173" checksum="AB66163705C5DC1B" modified="2006-07-11" version="1">MAFLGWLLALLSGCTSMRALCPLEGGRPWVEVRSPHFTVRTNLDTETAEEAAQELELLREGLLQAWGGSFDPPGTVDIIVLHNRSALEEFTNIRIEGFSTNTEDGPLLVLAGHAYALSEATADITTQAHELTHYLSELALVRQPRWLSEGLASYLETIALRPERREVILGRIHGAFYNQVQRHGWRTLDELWEWDSKGLLGTAESRQYYASSWLWVHFFISRHGVRFEDFQKRLMQGEEPRQAFEAAFRGEEDLAGELNGYVRRPGHMNYRTITAPLAPVTSPLQTRPMRAAEVHAIRAQLFLMTPGASPMEERLPHIEREMAEATREEPGNVDAMLLRIRSTEDPFRRLAVARELVEHHPASGHAWNAMAQALDAAGNTSEEQEAARLRAVALLPGSVSAQNGLAGYYARTAQPEKGLTAAQRALSLAPGNASVLDTWSTLLFQLGRCPEALDAQQLAVDMLHEGTPQRLRRTVHDTLARYEAVCGPDAPPAAVTPPTAAPAVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA50</accession>
    <name>Q1DA50_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative arginine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2252</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552328.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2252"/>
    <dbReference type="EnsemblBacteria" id="ABF90723">
        <property type="protein sequence ID" value="ABF90723"/>
        <property type="gene ID" value="MXAN_2252"/>
    </dbReference>
    <dbReference type="GeneID" id="41359640"/>
    <dbReference type="KEGG" id="mxa:MXAN_2252"/>
    <dbReference type="eggNOG" id="COG3869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019868_0_0_7"/>
    <dbReference type="OMA" id="IIMQERV"/>
    <dbReference type="OrthoDB" id="904915at2"/>
    <dbReference type="BRENDA" id="2.7.3.3">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031155">
        <property type="term" value="P:regulation of reproductive fruiting body development"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="SSF48034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="9">
        <location>
            <begin position="93"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="282"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="37910" checksum="7A1ACAFCCE48E233" modified="2006-07-11" version="1">MLLHKHLTPELKSRLERLTTRNGWTLRKTIQSGLDHGDSQMGVYAGDSESYALFSPLLHPIIRDHSGHDLSGHTSDFSLDGLPQGDLDPTGEFILSTRVRVGRNLARYAFPPAIGARDRAALEAEVVQVLSGLRGHLAGKYHPLASLSEAERLELVHHHVLFQQSDRFLDSAGVNRDWPRNRGIFHSADMRFIVWVGEEDALRIISMQPGSGLAQTYLRLQTALEQFDGQLDFAQDSRLGFLTACPTNLGTAMRASVLIRLPHLSRRPDFRARCARLGLAVRGLHGEHSEARDGIHDVSNATRLGVTERDIYEQLRTGIHALMEMESAARKRGHPKVAPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA85</accession>
    <name>Q1DA85_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552293.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2217"/>
    <dbReference type="EnsemblBacteria" id="ABF90077">
        <property type="protein sequence ID" value="ABF90077"/>
        <property type="gene ID" value="MXAN_2217"/>
    </dbReference>
    <dbReference type="GeneID" id="41359605"/>
    <dbReference type="KEGG" id="mxa:MXAN_2217"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_12_0_7"/>
    <dbReference type="OMA" id="FLYTAPF"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="158"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="32936" checksum="495C61D92877DFEC" modified="2006-07-11" version="1">MSSHRKPADGFALASMLALCAIWGMQQVAVKLAAPHIPSMMQMAVRSGVGALLVGLLCWVRGERGLLRRGPWRPGLVVGALFALEFLFVGEGLRHTHASHMGVFLYTAPIFAALGLHWLVPAERLRRTQWLGIAVAFVGIALAFGGGWLQGDISPGVLWGDALGLLAGLAWGATTVAIRVSALSDAPPTQTLLYQLVGGVALLLPVALLTGQAGPISMAPIAWASLLFQGVIVCFASYLTWFWLLRRYLASNLSVFSFMTPLFGVSAGILVLNEQADGFFAVGAVLVLTGILIVSGSSLLRHQPTLKTGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA93</accession>
    <name>Q1DA93_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552285.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2208"/>
    <dbReference type="EnsemblBacteria" id="ABF89083">
        <property type="protein sequence ID" value="ABF89083"/>
        <property type="gene ID" value="MXAN_2208"/>
    </dbReference>
    <dbReference type="GeneID" id="41359597"/>
    <dbReference type="KEGG" id="mxa:MXAN_2208"/>
    <dbReference type="eggNOG" id="COG4731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108869_0_1_7"/>
    <dbReference type="OMA" id="CTDARKD"/>
    <dbReference type="OrthoDB" id="1848240at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188421" description="DUF2147 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2147" evidence="2">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="17200" checksum="9F5F04AA61BD0301" modified="2006-07-11" version="1">MNATRWFGLASLTLLLASNAFAEDKAPAATNAAVGRWTTIDDETKKPKSVIAIYEENGKLYGKIEKLFREPKEEQNPLCDKCEGSLKNQPIIGMTILRDLKKDDDEWSGGSILDPANGKTYKCKVAVEDGGKKLKVRGYVGMSLLGRTQYWVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAB2</accession>
    <name>Q1DAB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552266.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2188"/>
    <dbReference type="EnsemblBacteria" id="ABF87636">
        <property type="protein sequence ID" value="ABF87636"/>
        <property type="gene ID" value="MXAN_2188"/>
    </dbReference>
    <dbReference type="GeneID" id="41359580"/>
    <dbReference type="KEGG" id="mxa:MXAN_2188"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_1_1_7"/>
    <dbReference type="OMA" id="IWSKGHR"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="502" mass="54004" checksum="8F6416B6C45299EE" modified="2006-07-11" version="1">MVPRCTAIGDGVLRATREASLCPMSGTVRPPVEARTFHSTRGTRCSIPFYPPGESRMRTLSMPLIVAALLSGCSQTPDPTPTPQDSGVPQLDSGVPPEDSGVPPDDAGVPPDDAGVPPEDPLPTGPPVPQGPPNVPEFDPAFPGQTRVPAIQTQTPIEVTEIASGFRNPWAIAFLPDQRMLVTEKPTGSLYIVTPQGAKSPAVVGLPNVDGRGQGGLLDVEVGPDYAQSQLIYWTYSEPRQGGNGLAVARAKLVDGAQPRVEDVQVIFRMMPTLESTLHSGGRLVFTPDGKLFVTLGERSILAGRVQAQELNSHFGKVVRINPDGSVPQDNPYVNTEGAKPEIWSVGHRNVLSAALDSQNRLWTVEMGPRGGDELNRPEAGKDYGWPTIGYGEEYSGAPIHESPRGPGMEQPVYYWDPVISPSGMTIYSGTLFPEWRNNIFIGGLSSQALVRLMMRNDRVVGEEHLLKDLGVRIREVVQGPDGALYLLTDATNGKLLKVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAQ4</accession>
    <name>Q1DAQ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552124.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2040"/>
    <dbReference type="EnsemblBacteria" id="ABF90249">
        <property type="protein sequence ID" value="ABF90249"/>
        <property type="gene ID" value="MXAN_2040"/>
    </dbReference>
    <dbReference type="GeneID" id="41359449"/>
    <dbReference type="KEGG" id="mxa:MXAN_2040"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_1_0_7"/>
    <dbReference type="OMA" id="ISSGWMT"/>
    <dbReference type="OrthoDB" id="1563802at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="146" mass="16324" checksum="E7ABF9EC5C505B78" modified="2006-07-11" version="1">MRYFEDFQPGDVSEHGPHVVSREEIIAFATQFDPQPFHLSDEAARDSIFGGLVASGWHTASLCHRLLVDSFLGQTSSMGSPGLDELRWLKPVRPGDTLHVRVEVVSATPSRSKPDRGAIKLRMEVRNQKDEVVMTELANVLFGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ1</accession>
    <name>Q1DAZ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552037.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1944"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91903">
        <property type="protein sequence ID" value="ABF91903"/>
        <property type="gene ID" value="MXAN_1944"/>
    </dbReference>
    <dbReference type="GeneID" id="41359357"/>
    <dbReference type="KEGG" id="mxa:MXAN_1944"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_7"/>
    <dbReference type="OMA" id="CDLTFYD"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="26433" checksum="DA67D7FA7445A638" modified="2006-07-11" version="1">MAPHLTVVIPVYNEESIIASAAEELRQGLDARGLDYEIIFAENGSRDATPAILEELCASNPRLRWFHSETPNYGVALKAGILKARGTYVICDEIDLCDLTFYDAALPRLERGEADMVVGSKAAKGASDQRPLIRRAATRVHNKLLKVALGFQGTDTHGLKAFRREALLPVIQKCVVDMDVFASEFVIRAWREGLRVMEIPIQLHEKRQPSIHLFKRVPNVLKNVGKLFYVIRVRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB49</accession>
    <name>Q1DB49_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551980.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1878"/>
    <dbReference type="EnsemblBacteria" id="ABF87613">
        <property type="protein sequence ID" value="ABF87613"/>
        <property type="gene ID" value="MXAN_1878"/>
    </dbReference>
    <dbReference type="GeneID" id="41359293"/>
    <dbReference type="KEGG" id="mxa:MXAN_1878"/>
    <dbReference type="eggNOG" id="ENOG5031HJZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1371497_0_0_7"/>
    <dbReference type="OMA" id="VNRQARP"/>
    <dbReference type="OrthoDB" id="1598712at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="21512" checksum="B3CDB496221DE1F7" modified="2006-07-11" version="1">MALTHLLQPTPAPQRPPGVTCEAYVRGEGKHCLHYRPGGGCTLPGVGGTCTEWLKVNRQARPHRDVTAQPVPAPPVKAAPAAVDLFGHPLTEAGSKKLAPAPASRPAPPAPSPDVKGLDAETPLSGLRGLTDEDIASFRALNAEVCFASETYGEVWLVPAYTGQARKELTPEHAATLVRVLSAFPGSRVMSFEKRQASADEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB84</accession>
    <name>Q1DB84_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1843"/>
    <dbReference type="EnsemblBacteria" id="ABF86242">
        <property type="protein sequence ID" value="ABF86242"/>
        <property type="gene ID" value="MXAN_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1843"/>
    <dbReference type="eggNOG" id="ENOG5032NIP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1238776_0_0_7"/>
    <dbReference type="OMA" id="MPLPICI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="228" mass="23614" checksum="EBE8FEF463BD1FA9" modified="2006-07-11" version="1">MRKPMALPICIHIPPLPQAPTLTLPGGATLQHHQLLQAVQPALAPLTPLFDIIGAVLALVEVVKAIPDALGPPPDPTAIAAALPKLAEKVSKLLRLVPQLSVPYTVVGVIDIVLGELGHARGQLLHLQLRLSSVAQARQRAAQLRDAGLLAVAGCAEANVAQEAANVGKALAALSQLMALLNVFLGLVGGPQVPDFSSLEGSPLEEAIAPLDAIVRTLQQVRAAIPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBC2</accession>
    <name>Q1DBC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551910.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1805"/>
    <dbReference type="EnsemblBacteria" id="ABF91260">
        <property type="protein sequence ID" value="ABF91260"/>
        <property type="gene ID" value="MXAN_1805"/>
    </dbReference>
    <dbReference type="GeneID" id="41359222"/>
    <dbReference type="KEGG" id="mxa:MXAN_1805"/>
    <dbReference type="eggNOG" id="ENOG502Z95Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085959_0_0_7"/>
    <dbReference type="OMA" id="GALYWNC"/>
    <dbReference type="OrthoDB" id="1256752at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="32525" checksum="11BB87D5CB16B0B2" modified="2006-07-11" version="1">MEKQRVLITVKTYPTLSRKYGETVCTAGVRKDGTWVRIYPVPFRRLDEKEQYSKFDWVECRLQRNTVDVRPETYRPVDQHELVPVGEMDTSHNWSERRDLLLKKSRVYDNLKELIAGAKANQISLAVFKPARIHDFIVEEDERDWDINKVREMREASRQHELFEDNTWRETFRVIPKLPYKFSYRFEDASGKKSEQQILDWEIGALYWNCLNRANGDERTAIAKVRQKYMDEFLKKDLHLFLGTTQQWHQVAPNPWVIIGVLPIPHEKQLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF1</accession>
    <name>Q1DBF1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1772"/>
    <dbReference type="EnsemblBacteria" id="ABF90728">
        <property type="protein sequence ID" value="ABF90728"/>
        <property type="gene ID" value="MXAN_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1772"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228824_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="225" mass="23625" checksum="BD77F12979135C9C" modified="2006-07-11" version="1">MGASKRIRPKLMTVAANRTGRLPALMGHRRTGSDVMKRIAALMVGGPATSFLLGEKANSHAPTASASWREGLQAISRPRHKLSYLTGEQCQFPGGISMRKLGYGLLVTTGLLIGTLAEAQGASQPPSAGRQADDSTRQQPGCACGMTGSGMMAHGMGGAGMNCPMRGMADVQVEQTQEGATLHLTAKNPSQVEDVQRMAEGMQRCMSGSGAPQQGQPASPRHQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI3</accession>
    <name>Q1DBI3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1740"/>
    <dbReference type="EnsemblBacteria" id="ABF91348">
        <property type="protein sequence ID" value="ABF91348"/>
        <property type="gene ID" value="MXAN_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1740"/>
    <dbReference type="HOGENOM" id="CLU_466057_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="585" mass="61477" checksum="3F8466FE98055FFC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBK8</accession>
    <name>Q1DBK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell wall surface anchor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551824.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1714"/>
    <dbReference type="EnsemblBacteria" id="ABF91006">
        <property type="protein sequence ID" value="ABF91006"/>
        <property type="gene ID" value="MXAN_1714"/>
    </dbReference>
    <dbReference type="GeneID" id="41359153"/>
    <dbReference type="KEGG" id="mxa:MXAN_1714"/>
    <dbReference type="HOGENOM" id="CLU_1169665_0_0_7"/>
    <dbReference type="OMA" id="VQQDPIK"/>
    <dbReference type="OrthoDB" id="2083725at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="23933" checksum="B0C5EC51EAF4F74C" modified="2006-07-11" version="1">MSDAYKALATGGLSSSNPQERSEALDALASAGKTSTETLKAGLETARDLEKYGSATRAANLSLKAAAPDLGLKGRLKIAHNLSMKAFNHADAGDVGTAEKFEALKKASRSSTTDIAAKAHGDSNNKAQKRLNQGIKTGAEKTADSAFDAAIEKGAKAAGGKLAKFAGRFVPGANVAVAGFDIATAIATSNSKDASPGKKITAWTTAAGSVLAATNIPVVSQVGAAFSTVSDLVGSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBK9</accession>
    <name>Q1DBK9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trigger factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551823.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DBK9"/>
    <dbReference type="STRING" id="246197.MXAN_1713"/>
    <dbReference type="EnsemblBacteria" id="ABF90873">
        <property type="protein sequence ID" value="ABF90873"/>
        <property type="gene ID" value="MXAN_1713"/>
    </dbReference>
    <dbReference type="GeneID" id="41359152"/>
    <dbReference type="KEGG" id="mxa:MXAN_1713"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760139_0_0_7"/>
    <dbReference type="OMA" id="DHIQSER"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_C" evidence="6">
        <location>
            <begin position="196"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="364" mass="40585" checksum="E1B6D6F91647A449" modified="2006-07-11" version="1">MHSPPDKSNPGQPLSIGELQGMGLLNQAPGAMAFRNATSPRLPLLREAPSLEELRVKMPELGGISPEAILDRFATLCRVVAPRREREPGEAVDSGDDVLLDVVGFANGRLIPFSARAEWRTEATPDPLLPGFFEAVVRARVGESVAVDLVLPDDYAVESLRGVPARFDVKMKAAYQVTLLGESSPELFAALGRGGTLDEVMEYIAGELIAQRDAQYLWDFQDHVMREVARRTHVEVPRSLIDEEIRQRWAEAEYPILVSLGLPHERVREGLDGWLLDDSTRSELEYRLRLALGLRAIAERDHIQSERESAEELFNSLAERAQLSRVELGRLLQSDKNLGRRFDTLTMHTAVVSHILSKADVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBN4</accession>
    <name>Q1DBN4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1687"/>
    <dbReference type="EnsemblBacteria" id="ABF86595">
        <property type="protein sequence ID" value="ABF86595"/>
        <property type="gene ID" value="MXAN_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1687"/>
    <dbReference type="eggNOG" id="ENOG5030P5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831121_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="36640" checksum="BB28030A784E0004" modified="2006-07-11" version="1">MLAFVALWTSITLAADYFTVSNMVLQMQTESWPSVQGTITRSEVDAVRSNKATTYGLKVAYTYSVDGQQYEGSKARPSMWRSGDRGFAEELVARYPLGATLPVYYRPGQPSEAVLQTGMDGSQLFTLMLLMPFNLVMLWLGTLVVGAWKPEPPLLSTFFREDGSECVTLEGPWTATLVSLVLVGASLACVALAGLTVGLHAPLPVAVGAWGVVIVSGVLVGRWSHTRVKAGYYDLRLHPQERSLSLPPFSGRKHGLDVRWRDVRSLRVEPQAPTQKGGQVSRYHLTLELSTADGGVRQEAIAGFPRQEQAESLARWLRTRLEVGEVASEEQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX6</accession>
    <name>Q1DBX6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551706.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1595"/>
    <dbReference type="EnsemblBacteria" id="ABF91311">
        <property type="protein sequence ID" value="ABF91311"/>
        <property type="gene ID" value="MXAN_1595"/>
    </dbReference>
    <dbReference type="GeneID" id="41359040"/>
    <dbReference type="KEGG" id="mxa:MXAN_1595"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_1_7"/>
    <dbReference type="OMA" id="HYYSAQK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="315" mass="34419" checksum="58957A3B18EB4AAD" modified="2006-07-11" version="1">MRVLIPGISGGIARQLALHLHARGHQVAGIDTRPWAEAKEAGIQVYRGDVRKRAAEDVFRRWRPEAVVHMATVTAFTVPGKERGRINLDGTKAVFDHCAAHGVKQMLFVGRHTFYGAAPDSPLYHSEDEPPRALEAIPELADLVAADLYAATALWRLPKMTTAVLRLPYTLGAPGTGTLSSFLKGRRVPLVLGYDPLFHVLQEEDVVTALTLALEKQVRGLFNVAGPPPIPLSVIVRETGRRAVPLPAPLLSMLLGRAGLPRLSMGALDHLRFPIVVDNRRFLDATGFEYRHSVADSLRIFRESSPILPAGGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCA1</accession>
    <name>Q1DCA1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551581.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1465"/>
    <dbReference type="EnsemblBacteria" id="ABF90265">
        <property type="protein sequence ID" value="ABF90265"/>
        <property type="gene ID" value="MXAN_1465"/>
    </dbReference>
    <dbReference type="GeneID" id="41358911"/>
    <dbReference type="KEGG" id="mxa:MXAN_1465"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069346_0_0_7"/>
    <dbReference type="OMA" id="RPWPPDP"/>
    <dbReference type="OrthoDB" id="667331at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="37509" checksum="B6E72369B8942F6B" modified="2006-07-11" version="1">MDTATDLVELFALQPRVSLEDYASPAAFAARHRALAAKVDALRARDASGQPRYPALAVWPESVGAPLLFLGHMHRVRQSTSLQGALKRVRLSEAWGVWNAWSDFRPPSLTECIYAARAPLVHRTLWNTFSGIARDFGLWVVAGSALLPAGRRGEGSPDFEPFSARTYNTSYTFSPEGNCVAAARKANLVPSWEDGLHLSPGRPEDLAVLQTPFGKLATLIGYDGFAQPHTRDEPWFAPCAQYLDAMRVDVLAHPAIHAGPWARSAQGERWRHEGLPAQLRTLRNVRYVVSAQQVGSLLGGTFEAASHILERTASGDVRVLAQAQTTQEEDVVHAIVPTAAHGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCE6</accession>
    <name>Q1DCE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551537.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1420"/>
    <dbReference type="EnsemblBacteria" id="ABF87043">
        <property type="protein sequence ID" value="ABF87043"/>
        <property type="gene ID" value="MXAN_1420"/>
    </dbReference>
    <dbReference type="GeneID" id="41358866"/>
    <dbReference type="KEGG" id="mxa:MXAN_1420"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042757_0_0_7"/>
    <dbReference type="OMA" id="FFLHDVD"/>
    <dbReference type="OrthoDB" id="290240at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="60756" checksum="CBD0D25050F88943" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCP9</accession>
    <name>Q1DCP9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551434.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1317"/>
    <dbReference type="EnsemblBacteria" id="ABF91014">
        <property type="protein sequence ID" value="ABF91014"/>
        <property type="gene ID" value="MXAN_1317"/>
    </dbReference>
    <dbReference type="GeneID" id="41358763"/>
    <dbReference type="KEGG" id="mxa:MXAN_1317"/>
    <dbReference type="eggNOG" id="ENOG503304P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243891_0_0_7"/>
    <dbReference type="OMA" id="AWDIAFH"/>
    <dbReference type="OrthoDB" id="1118154at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12105">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025921">
        <property type="entry name" value="HmuY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14064">
        <property type="entry name" value="HmuY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188142" evidence="2">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23083" checksum="43917C1E1A3A668F" modified="2006-07-11" version="1">MSRFSSHSSFLGRAAAALLLAGSLSACGDDLELPSENPPTDGSHVNHVANDDGSYTTTVNATSSADWIGLDLDKGAQVSASDDTVWDLAFNRFNVRTRGGVSGTGNVAVAVLLETDFAAVTRAPADGYVADSEDGPDRGEDPDSAFQQGDGWYVYDMTTHALTARRNVYVVRSDAGDYFKVAMQSYYDDAGTPGMLSFRWAKVPGPASSGSAVTQPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT2</accession>
    <name>Q1DCT2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-isopropylmalate synthase/homocitrate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1284"/>
    <dbReference type="EnsemblBacteria" id="ABF89693">
        <property type="protein sequence ID" value="ABF89693"/>
        <property type="gene ID" value="MXAN_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1284"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_7"/>
    <dbReference type="OMA" id="CALARCN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="421" mass="45911" checksum="38487DE6E7581404" modified="2006-07-11" version="1">MRDPARTVSHSEFIHDWNGRGAAPSPAFPVEINDETLRDGMQATAVTSPTVEEKRGLLELMQHIGVSAVSLGMPAAGPWALEEVVTLARHIREEALRLEPNCAARTLHSDIVPIVEAVQRAGQPIVVHTFIGSSPLRQCAEAWDLDFILRSSTAAIDFAVRQGLEVAFITEDTTRSTPETLELLFRAAVEHGASRLVLCDTVGHATPAGTRALVRWTRDLVERLGSPVKVEWHGHNDRGLALINALVALEAGATRVHGCGLGIGERTGNAPVELLLLNLKLLGWIDQDLTRLVDYVLTLAQVCRVPIPRNYPLVGEDAFRTATGVHSAAIIKALERGDDWLADHIYSSVPAGEFGRRQQLELGPMSGMSGVRYWLMVRGLQENEQLCEEILRRAKSAASTLTEEEVWSIVQAHGGQGRSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT3</accession>
    <name>Q1DCT3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551400.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1283"/>
    <dbReference type="EnsemblBacteria" id="ABF89148">
        <property type="protein sequence ID" value="ABF89148"/>
        <property type="gene ID" value="MXAN_1283"/>
    </dbReference>
    <dbReference type="GeneID" id="41358728"/>
    <dbReference type="KEGG" id="mxa:MXAN_1283"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_7"/>
    <dbReference type="OMA" id="KKGDPWP"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="3"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="38312" checksum="B0B38E2D8C2BCDCC" modified="2006-07-11" version="1">MARIAVIPGDGIGIEVTREVMRILQVLDAEMRLGLSLEAFDFGAERFLRTGVGLPPGQMDVFRTEFDAILLGAMGDPRVPDNAHAREILLGLRFGLDLYVNFRPCSPLAERLSPLKGKGPQEIDMTIFRENTEGIYGAIGGSFKRGTLDEVAIAEEIHTRKGVERIIRAAFKWASAHGKRHVALGDKSNAIAAHGLWLRTFREVAAEYPQIEARHYYVDALALQMVTRPESLQVIVTTNLFGDILTDLGAALSGGLGVAPSANLNPDSTPLFEPVHGSAPELTGKGLANPAAMVLSAALMLEHLGQAGAARRLSTAVQQTVAEGQCTRDVGGTLSTTEAADAILDRMLQGLRRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD20</accession>
    <name>Q1DD20_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551313.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1194"/>
    <dbReference type="EnsemblBacteria" id="ABF86892">
        <property type="protein sequence ID" value="ABF86892"/>
        <property type="gene ID" value="MXAN_1194"/>
    </dbReference>
    <dbReference type="GeneID" id="41358644"/>
    <dbReference type="KEGG" id="mxa:MXAN_1194"/>
    <dbReference type="eggNOG" id="COG2162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049918_1_0_7"/>
    <dbReference type="OMA" id="FCKSLCT"/>
    <dbReference type="OrthoDB" id="1687886at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="28322" checksum="02A3829397BDCC99" modified="2006-07-11" version="1">MFDVARYLERIGVGAEQSLTRLHRAHLEAVPFENLDIHLKRPIRLDMNALFEKVVVQRRGGFCYELNGLFARLLTALGHRVTLLSAGVATAPDGSAYGPEFDHLALQVEDEQGRWLADVGFGECFTEPLRLDTHDVQVRSGRAYRLSPEGNNLILWSEKPSGWEAEYRLSLVPRQLADFEGMCRYHQTSPDSIFTQRRLCTRATPEGRITAKEGTLVLTRSGVRTEQPLPDEDALRRALVEHFGVILPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDG8</accession>
    <name>Q1DDG8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1044"/>
    <dbReference type="EnsemblBacteria" id="ABF92959">
        <property type="protein sequence ID" value="ABF92959"/>
        <property type="gene ID" value="MXAN_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1044"/>
    <dbReference type="eggNOG" id="ENOG5033CEF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670536_0_0_7"/>
    <dbReference type="OMA" id="HRQHARQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="39986" checksum="58505B57D510F565" modified="2006-07-11" version="1">MMPDGRAPSRASPGGSMPPGASALHALLRAWPDAPVRAAPEGAEADGLVHTAVGHGLVGFVAHAVERAGWALPEPASASLRREALGNAARALRVKMLLLRSLDALATVGQVPVLLKGVWAGAAAVSGPVAASHHGRGPAGGTRGCGRRGPGAGPRGALGAAGRRRPARGRGLSPLGAGRAGGAGGAALPRARGMGRGAGGRRAAGAGGDGRGGWPGGAVATARGRGRLPGVAREQPRVAAVGVALRLEAAGAGGYAAGLADGGGAGTRHGLPTCGLVCVGRGAAAPGGAGAGRGAGAAGSASLAASARTAFFLRRAAAGGVAAGWPDRVDGGEAAAGATDGLRGAIWRPASTERRAGEAAPSRLSWVRGMPPPQPARPSHRQHARQRLHANLPHEGDATLPAVRDPRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH8</accession>
    <name>Q1DDH8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551155.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1034"/>
    <dbReference type="EnsemblBacteria" id="ABF85908">
        <property type="protein sequence ID" value="ABF85908"/>
        <property type="gene ID" value="MXAN_1034"/>
    </dbReference>
    <dbReference type="GeneID" id="41358488"/>
    <dbReference type="KEGG" id="mxa:MXAN_1034"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1280816_0_0_7"/>
    <dbReference type="OMA" id="VYDFELR"/>
    <dbReference type="OrthoDB" id="969989at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="25314" checksum="F7BB3E4477D2D40C" modified="2006-07-11" version="1">MRPGGNIFQFLKREVLVGEHEVLHRTLKEALVGTCDSVLDIGCGSRSPLHSFSNLLPHTVGVDGHPTSIERSRAAGIHREYHCMDLMEAGQRFGPKSFDAVVALDVIEHFDKPGGFRLLEMMESLARKRVIIFTPNGFLPQDEWDNNVHQVHRSGWEVYDFELRGYHVTGMSGWKPLRGDYALPRIRPFRLGSRLSILTEPFATRWPRHAFQLLAIRDMEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDK7</accession>
    <name>Q1DDK7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551126.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1005"/>
    <dbReference type="EnsemblBacteria" id="ABF89981">
        <property type="protein sequence ID" value="ABF89981"/>
        <property type="gene ID" value="MXAN_1005"/>
    </dbReference>
    <dbReference type="GeneID" id="41358460"/>
    <dbReference type="KEGG" id="mxa:MXAN_1005"/>
    <dbReference type="eggNOG" id="COG5555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266861_0_0_7"/>
    <dbReference type="OMA" id="YRTGTQN"/>
    <dbReference type="OrthoDB" id="13091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="8"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1245" mass="126935" checksum="113D439CD3406F6A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDL2</accession>
    <name>Q1DDL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1000"/>
    <dbReference type="EnsemblBacteria" id="ABF91248">
        <property type="protein sequence ID" value="ABF91248"/>
        <property type="gene ID" value="MXAN_1000"/>
    </dbReference>
    <dbReference type="GeneID" id="41358455"/>
    <dbReference type="KEGG" id="mxa:MXAN_1000"/>
    <dbReference type="eggNOG" id="COG2322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104065_0_0_7"/>
    <dbReference type="OMA" id="HRKIARW"/>
    <dbReference type="OrthoDB" id="1623896at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="20515" checksum="AAB936F5F45A4113" modified="2006-07-11" version="1">MSNAAPAALPPRVSDRAFFIFTAVVSALALAFIGWILLVRGGGPVEGVNLRFLPAVNAGLNATAAALLIGGWVAIKRGARQVHQYLMVSAFTASALFLVCYLSYHFVHGDTRYVGDWRGLYLCILASHVLLSMPVVPMALVAFYFTWRKDFVRHRKVTRWLAPIWVYVSATGVVVYFMLRGSAPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE00</accession>
    <name>Q1DE00_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppa</name>
        <name evidence="6" type="ORF">MXAN_0862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
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        <property type="protein sequence ID" value="ABF87482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550983.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0862"/>
    <dbReference type="EnsemblBacteria" id="ABF87482">
        <property type="protein sequence ID" value="ABF87482"/>
        <property type="gene ID" value="MXAN_0862"/>
    </dbReference>
    <dbReference type="GeneID" id="41358321"/>
    <dbReference type="KEGG" id="mxa:MXAN_0862"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_1_7"/>
    <dbReference type="OMA" id="YDWGFIP"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="19794" checksum="6B4E2DF06CCC2208" modified="2006-07-11" version="1">MVTDLTRLPLRGKQGAFHVIVESPRGSTLKLKYDTALKAFSLSRPLPRGLSYPFDWGFIPSTQGPDGDPLDAMVYWDDASFPGVVLPCHALGVLQVEQNTGDGGRERNDRILAVPITPSRAGHLTDYQQLPQREREELEHFFLAAVRFEDKDARILGWEGPEGVERMLRQHGRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE9</accession>
    <name>Q1DEE9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0706"/>
    <dbReference type="EnsemblBacteria" id="ABF91886">
        <property type="protein sequence ID" value="ABF91886"/>
        <property type="gene ID" value="MXAN_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0706"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025061_0_0_7"/>
    <dbReference type="OMA" id="QECGANA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="306"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="59135" checksum="B7B4611C0A354F76" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP8</accession>
    <name>Q1DEP8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550738.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0607"/>
    <dbReference type="EnsemblBacteria" id="ABF86444">
        <property type="protein sequence ID" value="ABF86444"/>
        <property type="gene ID" value="MXAN_0607"/>
    </dbReference>
    <dbReference type="GeneID" id="41358085"/>
    <dbReference type="KEGG" id="mxa:MXAN_0607"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_7"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="471" mass="50961" checksum="BEE34F1AAC7839BE" modified="2006-07-11" version="1">MAISTIDPATGKTLRTFTPLSAEELEAKLQTAADTFRTYRETTFADRVTWLRRAADLLEAEADRYGRIMTQEMGKPIDAAKAEAKKCATACRYYVDKGESLLRDRLVDMGTGRAFVRYQPLGPVLAIMPWNFPFWQVVRFAAPALMAGNVGLLKHAHNVPQCALALEELFLQAGFPRGAFQTLLIETADVHRVIEDRRVRAVTLTGSEGAGRAVGAAAGKAIKKVVLELGGSDPFIVMPSADMEKAVETAVSARLINNGQSCIAAKRFIVADAIYPEFERRFVERMKRVTVGDPMDAKTDLGPLATRGILDGLHAQVEASVKAGARLLLGGKPLEGPGNFYPATVLAEPPPQAPAFHDELFGPVATLLRARDVDHALELANATPFGLGASVWTQDEAEQRRFIDGIDAGMVFVNALVASDARLPFGGVKHSGHGRELADVGIHEFVNIKSVRIAAAEETKQQPPPRGTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DES6</accession>
    <name>Q1DES6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550710.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0579"/>
    <dbReference type="EnsemblBacteria" id="ABF87671">
        <property type="protein sequence ID" value="ABF87671"/>
        <property type="gene ID" value="MXAN_0579"/>
    </dbReference>
    <dbReference type="GeneID" id="41358059"/>
    <dbReference type="KEGG" id="mxa:MXAN_0579"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067698_2_0_7"/>
    <dbReference type="OMA" id="NPEWGVR"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="PTHR20974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="22260" checksum="D80CA83FDA69AE3C" modified="2006-07-11" version="1">MKRHAPATERNREPLLAVLREVLPASGRVLEVASGTGQHAAWFARALPHLVWQPTDVDAESLESIEAWRTAEGPPNLLPPRQLDASAASWPETAADVILNVNMIHIAPWTACQGLMRGAGRVLPPGGLLVLYGPYFVEGRETAPSNLEFDASLRARNPAWGVRSLEAVTAEAALHGLERERVVDMPSNNLTVVFRKPRPQVSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFB6</accession>
    <name>Q1DFB6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550521.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0385"/>
    <dbReference type="EnsemblBacteria" id="ABF90827">
        <property type="protein sequence ID" value="ABF90827"/>
        <property type="gene ID" value="MXAN_0385"/>
    </dbReference>
    <dbReference type="GeneID" id="41357881"/>
    <dbReference type="KEGG" id="mxa:MXAN_0385"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_7"/>
    <dbReference type="OMA" id="VDPRSYM"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="470" mass="51082" checksum="122B72CCFC15019E" modified="2006-07-11" version="1">MDPITPPLALGQKHVVVLGAGFAGLTAAKALARHSALYVTVLDQRNHHLFQPLLYQVATSGLSPADIAVPIRSQFARKPNVSVHLGRVTWVNLKERWVGGEGDVRLRYDYLVIACGAQHSYFGKSEWEDFAPGLKTLEQATELRRRILSAFEQAENERDAERQRALLSFVVVGAGPTGVELAGAIADISRTVLVRDFRRIKPSRARVFLVEAGPRILPSFSEKLGVRAHRDLAALGVEVRTEARVTAVDAEGVMLGSERLASRTVVWAAGVQAEYLTRGLGVPLDRAGRVQVAADLTLPGHPEVFAAGDVAHVELDGKLVPGVAPAAMQMGRAVARNVLADLRGRPRTPFRYKDKGAMATIGKHRAIAETGRARLTGFVAWVAWLFIHVWYLVGFKNRFGVFVTWVWSYLFSTRGARLITEREWRLSPKVASERAPHAGKVTAGDPTAPTSDARPPDGTTTTAAAALVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG8</accession>
    <name>Q1DFG8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550469.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0331"/>
    <dbReference type="EnsemblBacteria" id="ABF88274">
        <property type="protein sequence ID" value="ABF88274"/>
        <property type="gene ID" value="MXAN_0331"/>
    </dbReference>
    <dbReference type="GeneID" id="41357829"/>
    <dbReference type="KEGG" id="mxa:MXAN_0331"/>
    <dbReference type="eggNOG" id="COG5383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053061_1_1_7"/>
    <dbReference type="OMA" id="VAKHFEH"/>
    <dbReference type="OrthoDB" id="714422at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1338" evidence="1">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="27604" checksum="B876B7BCE734D8F1" modified="2006-07-11" version="1">MTTDSAHRLLDLLWERYAAEVPYARTFVQLSGGRFRNDHVALRSLARPGGGIALFSQSFIRLGWKAAGAYTFPDAHLSAIYLSHPAGLPRIFISELKQEELSPRARELLARLPEDPAPPEDVDALAAWFGSPPPPDEAALLELEKESQYGAWLLAFGRKVNHFTGSVDDVEAWQKRMREAGVPMKADIEGAPGTSLRQTATQAAPLPVLLEGGGSRSWPYAYFEIAQRTPDFDGFLGPQARALFDMTKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN3</accession>
    <name>Q1DFN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550404.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0259"/>
    <dbReference type="EnsemblBacteria" id="ABF93003">
        <property type="protein sequence ID" value="ABF93003"/>
        <property type="gene ID" value="MXAN_0259"/>
    </dbReference>
    <dbReference type="GeneID" id="41357759"/>
    <dbReference type="KEGG" id="mxa:MXAN_0259"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="MNGWEFA"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="12995" checksum="A4DAB7CC2B6189B6" modified="2006-07-11" version="1">MSRPLLVVDDDADLREALEEVLRDAGYTVLGASNGKHALEVLGAATELPGLVLLDMMMPVMDGGGFARAMRQVSAWRDIPVLVFSASANARQVADEIGACGHLRKPVDVDTLLDAVSRHLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX9</accession>
    <name>Q1DFX9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ni_hydr_CYTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0161"/>
    <dbReference type="EnsemblBacteria" id="ABF86553">
        <property type="protein sequence ID" value="ABF86553"/>
        <property type="gene ID" value="MXAN_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0161"/>
    <dbReference type="eggNOG" id="COG4117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075520_1_0_7"/>
    <dbReference type="OMA" id="WHFFFAW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="3">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="24637" checksum="5937F626C22760CE" modified="2006-07-11" version="1">MQAPERRRPQPWLIRVTHWLNVPLLLIMAASGLQILVAYPMLGPQGRPYGWYPYQGIPPPEWMRLGNWLAGARHWHFAFAWFLILNGVAYVLYLALSGEWRRRLFLPRRDTRNALDTLAFYLRVRKHAPAQGLYNGLQRLAYTGTLALGLLAVLSGLVLYKPVQFGALTSLLGGYDAARAIHLVILALLALFTVGHITLVLLHPRSLAEMVTGGRKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY1</accession>
    <name>Q1DFY1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550306.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0159"/>
    <dbReference type="EnsemblBacteria" id="ABF89784">
        <property type="protein sequence ID" value="ABF89784"/>
        <property type="gene ID" value="MXAN_0159"/>
    </dbReference>
    <dbReference type="GeneID" id="41357662"/>
    <dbReference type="KEGG" id="mxa:MXAN_0159"/>
    <dbReference type="HOGENOM" id="CLU_1775451_0_0_7"/>
    <dbReference type="OMA" id="MSFEYDA"/>
    <dbReference type="OrthoDB" id="1715705at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="16275" checksum="045D8B04513C79FA" modified="2006-07-11" version="1">MAWNMSFEYDALNDVVTAYFTDCVLVSEADVLRWRKEVEEHLSKYPPKVDLLINLDGLVVKFTAGRVFGKERREVLERYTHRSYRFGGDEMTRMFVLTSGAINGAAVNHYATRDEALAALQAEREALRKRGFSPFGGGFAGSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY2</accession>
    <name>Q1DFY2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550305.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0158"/>
    <dbReference type="ESTHER" id="myxxd-q1dfy2">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87570">
        <property type="protein sequence ID" value="ABF87570"/>
        <property type="gene ID" value="MXAN_0158"/>
    </dbReference>
    <dbReference type="GeneID" id="41357661"/>
    <dbReference type="KEGG" id="mxa:MXAN_0158"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_7"/>
    <dbReference type="OMA" id="VHGWFAD"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="27302" checksum="BBB0086836E0D40D" modified="2006-07-11" version="1">MPTTSAKDGTSLHYRVVGEGPRTVILVHGWMVSGAVWDALVERLDLTGLRLVIPDMRGSGQSGRPDGGFSLESLAHDVLAVADAVDARRFTLVGHSMGGQLVKWVAAEVPARVEGLVLLNTVPAAGLPLPPDAAGLFRTSADSREKKQTILGLACKQLSPEALEALVKDSMGVSPAAIEHVFDAWTAGGFADKLASITAPTLVLATDDAFLPAAFLREAVVSRIRGARLSYLPGPGHYPQVERPAETAALVSAFLAGSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG64</accession>
    <name>Q1DG64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing enzyme family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550223.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0076"/>
    <dbReference type="EnsemblBacteria" id="ABF93018">
        <property type="protein sequence ID" value="ABF93018"/>
        <property type="gene ID" value="MXAN_0076"/>
    </dbReference>
    <dbReference type="GeneID" id="41357583"/>
    <dbReference type="KEGG" id="mxa:MXAN_0076"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_2_7"/>
    <dbReference type="OMA" id="AIVNAWN"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="16580" checksum="09E8B9749CE6B1C8" modified="2006-07-11" version="1">MPVSVVEGDLLDQPVEAIVNAWNRNIIPWWLLLPQGVSGAIKRRGGVGPFREVARAGPMPLGSAVVTSAGRLPFKAIIHVAGIDMLWRASERSIQDSVRNALAKAREQGFRSVAFPVIGAGSGSFDEARALELMRQVLDVEAGALDVSVVRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL4</accession>
    <name>Q1CVL4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7454"/>
    <dbReference type="EnsemblBacteria" id="ABF92401">
        <property type="protein sequence ID" value="ABF92401"/>
        <property type="gene ID" value="MXAN_7454"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7454"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377404_0_0_7"/>
    <dbReference type="OMA" id="WMATVAY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23738" checksum="E4BEA702B1D48055" modified="2006-07-11" version="1">MVSSIFPAPDVGHFVDPVGPSRRGPLSDDTSAETGPWLARFHAGDARVLNACYRDHFDTVYRAAVRVLPAVDAETVVHDVFLRLVSDEAARRSFQGGSLAGWLHTLSHNLAVDRVRRQRRESDALAQLAVESSASEEPTPPEPGLDASFLLERFRQESLPPKWAPVFEARFVLQLSQREAAAALRMRRTTLAYQELRVRQLLKKFLLTPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVQ5</accession>
    <name>Q1CVQ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mobA</name>
        <name evidence="6" type="ORF">MXAN_7412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557323.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7412"/>
    <dbReference type="EnsemblBacteria" id="ABF87181">
        <property type="protein sequence ID" value="ABF87181"/>
        <property type="gene ID" value="MXAN_7412"/>
    </dbReference>
    <dbReference type="GeneID" id="41364568"/>
    <dbReference type="KEGG" id="mxa:MXAN_7412"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_2_1_7"/>
    <dbReference type="OMA" id="HENGYIE"/>
    <dbReference type="OrthoDB" id="2019898at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22175" checksum="719AE74BF8008900" modified="2006-07-11" version="1">MSMERIRTDFPEVTLAILAGGQGRRLSGVPKGLLEVEGRTVLERLLALAPCFEDVLLVANVPGPYARFGLRTVADVVPGKGAPGGVHAALVAARTPWVVAVACDMPFITTEVLRVLLGARDDGVDAVCFEARGRLEPLLAAYRSALAPAWETTLATDPSMRELLSGVRTRLLSEAVLHAVDPSLRSLANVNTPEDLARYGVALPSWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVY4</accession>
    <name>Q1CVY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557245.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7326"/>
    <dbReference type="EnsemblBacteria" id="ABF85921">
        <property type="protein sequence ID" value="ABF85921"/>
        <property type="gene ID" value="MXAN_7326"/>
    </dbReference>
    <dbReference type="GeneID" id="41364489"/>
    <dbReference type="KEGG" id="mxa:MXAN_7326"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_2_7"/>
    <dbReference type="OMA" id="RIDHGLP"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="143"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="22905" checksum="E4AFD99F311C70FF" modified="2006-07-11" version="1">MALLSAMKMVLAGAPPSDTDRERTLLRRARTGDPAAFRWLFERHAAGVWRFLKDLLRDEAAADEATQETFVRAHARLGALRDEDRLGAWLLGIARHVYLESLRHRGAHVDMDDEVHGSQVEAMLPTPTPEDLLLDRELEGLLAGALGTLREDRRAALLLRIDHGLPYEEISAVMGWSLQKVKNEIHRARLQLREHLAAHVGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW42</accession>
    <name>Q1CW42_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557187.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89287">
        <property type="protein sequence ID" value="ABF89287"/>
        <property type="gene ID" value="MXAN_7268"/>
    </dbReference>
    <dbReference type="GeneID" id="41364433"/>
    <dbReference type="KEGG" id="mxa:MXAN_7268"/>
    <dbReference type="HOGENOM" id="CLU_905609_0_0_7"/>
    <dbReference type="OMA" id="VAVVQWP"/>
    <dbReference type="OrthoDB" id="1335330at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011754">
        <property type="entry name" value="Mxa_paralog_2268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09544">
        <property type="entry name" value="DUF2381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02268">
        <property type="entry name" value="TIGR02268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188112" evidence="2">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="33095" checksum="C06F979FC6C9B6E9" modified="2006-07-11" version="1">MFPPGSLAMTAVVLLLGTAALAQTPDTKRWRRIERAMVLSASAGEPVQRLRLAPGVVTTVLLDSDAVLEGELPEALHGLFTRLDVTETHLLLQPAVAMPARGVPPLVLRFTDAAAPQRLVLELTTEANVVDSVIDVRRHPATVTQLEAELVALRERNALLEARLATARRQVPHPGLAGAILSGAIGITGVLGTWMDTPASEAELKVRQLDSYRSGSWVALAVNLENPPGEAPWQPGIARLTSLDSNGRPTGEPMELPLLLQEPRLLPGQSAVAVVQWPAPTRPPPAYALELWDTGRRRGVRWARLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH1</accession>
    <name>Q1CWH1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557058.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7139"/>
    <dbReference type="EnsemblBacteria" id="ABF92190">
        <property type="protein sequence ID" value="ABF92190"/>
        <property type="gene ID" value="MXAN_7139"/>
    </dbReference>
    <dbReference type="GeneID" id="41364313"/>
    <dbReference type="KEGG" id="mxa:MXAN_7139"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025328_0_0_7"/>
    <dbReference type="OMA" id="DMATPNT"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187994" evidence="2">
        <location>
            <begin position="30"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="5">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="165"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="365"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="635" mass="66387" checksum="21649953CAFB9739" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI8</accession>
    <name>Q1CWI8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557041.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7122"/>
    <dbReference type="MEROPS" id="S01.221"/>
    <dbReference type="EnsemblBacteria" id="ABF89983">
        <property type="protein sequence ID" value="ABF89983"/>
        <property type="gene ID" value="MXAN_7122"/>
    </dbReference>
    <dbReference type="GeneID" id="41364296"/>
    <dbReference type="KEGG" id="mxa:MXAN_7122"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661936_0_0_7"/>
    <dbReference type="OrthoDB" id="2024037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006993339" description="Serine protease" evidence="3">
        <location>
            <begin position="18"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="180"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="415" mass="44456" checksum="2FC50E8B08A3876A" modified="2006-07-11" version="1">MLRGIRRSMFCALGLMAAACGGDGSRAQEAPPVQVVPEAWLGEAAGAELPHLEALGDVRMLKDVNAEALFREASARQPAGSTRAAAEAPVRPTTERAFIGIDVKNNKAYRLRTDTANLERVAEELARRGLNGASRGTLDDAARLEPVNGDEALTSGTVSGQTWSNGVDTRIRMGLTDGYATNSWPYRTIGHLSAGCSGALVGRRVVVTAAHCVVSAYSGWNPIFNTFTARRDGATAPWGVQDAIWYWVPEGYINGSCNSVASCNRYDVAIMVLEDDFPNGHPGWMGHWNASTDTLKTWSSFMRGYPGCGHVAAPASCTARTLYGDTQQCKTSNAYSPDADGWHQEIEIGCDGSPGQSGSPIYSYDAPVSGPVVVGQYNQYYCDATGCAGNAFPNRMGHLTPSWNNSISYFKSLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR8</accession>
    <name>Q1CWR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556961.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7042"/>
    <dbReference type="EnsemblBacteria" id="ABF86228">
        <property type="protein sequence ID" value="ABF86228"/>
        <property type="gene ID" value="MXAN_7042"/>
    </dbReference>
    <dbReference type="GeneID" id="41364217"/>
    <dbReference type="KEGG" id="mxa:MXAN_7042"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680979_0_0_7"/>
    <dbReference type="OMA" id="VDFQHYL"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="308"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="46545" checksum="6B79A927A90D65DF" modified="2006-07-11" version="1">MWKTPASRGRSPPFMGSATHGAWSGTWRAQGVGPGVPGGVHGMARSTVEPGHGDELPASTGTRPFWEAVAQGTVDVAVRIYEALAASQRDVVLEESSRASAFARATLVSVLRRARDFAGAARVLEVDGAAADVAQLHEQAGALLLAAEAWLRAGEPARAAAAFERGGALERALSLYESLQAREAMARCLTRLRRPMEAAAVYRELGNPHAELESLRAVSPDIAVARREAVLRMSALLDAQGESWRALVLLADALQAPELRGDIALQAEHSRLLRHLNLNGGPSVEPARAPPLPPPPPDGYEYLKAIPLFGELSLVDMKDLYQLARPLQFAQGATVLEKGAPGSGLLVLLEGTVDVLAGPEPGARLLNTLGPGAFIGEVSLILDGDTSAQVCARTDVRALRVTRVDFQHYLDTHEAAALRILRLFTEKLAERVRALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX55</accession>
    <name>Q1CX55_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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    <sequence length="565" mass="59298" checksum="97E5EBB95FB03FBD" modified="2006-07-11" version="1"> </sequence>
</entry>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
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            <dbReference type="EMBL" id="ABF87282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="63" mass="6998" checksum="D2AB833957F42EDE" modified="2006-07-11" version="1">MVSRTVTPTVPPCVDSALTALGEERMEPIAMLATWALRRREAVKQAHAAYDAREEPPAPREPR</sequence>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Barbazuk W.B."/>
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                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            <dbReference type="PubMed" id="17015832"/>
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    <sequence length="387" mass="41715" checksum="95D488390293CDDF" modified="2006-07-11" version="1">MRASLTLLPALVVLALSASACRKSQAQGTASPQDCILVEKGWGADGTVPFNVEVVARGLETPWGIAWLPGGDALVTERPGRIRLLKDGVLQPRPVATVPVADAAEGGLLGIAAHPNFANNRQFYIYVTTDAGGTEENRIERWTLSEDHTTATHERVIFGGIASAKYHDGGRLRFGSDGMLYAGTGDARDPDRSQNANDPAGKLLRLTPEGAVPQDNPIPGSPAFLTGIRNLQAFDWRDASTLYIADHGPSGETLRRGHDEVSVARRGDNLGWPGIYSCETREGQITPSITYKDAMPPGGAAIYTGTAIPEWKGSLLIGTLGSRHLQRVEFAPDSSRVTRHEVYLRNTYGRLREVIMGPDGHLYVTTSNCDGRGDCGPDKDVILRLKR</sequence>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
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    </reference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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    </evidence>
    <sequence length="721" mass="73930" checksum="F6C3FA85B1A954E6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ77</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF90338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABF90338">
        <property type="protein sequence ID" value="ABF90338"/>
        <property type="gene ID" value="MXAN_6165"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_626596_0_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="503" mass="53865" checksum="3899A699FED8F37F" modified="2006-07-11" version="1">MVAARSPGSLAGATVPSGLRAHGSGDAPSRPRADDRARLDRVRFCGGDSNVLLVRPRPSRSRSRHMHRLLPLIVLFLMACGDKPGKPPPAEPGPSNAPIQGSLTVHSRLWEDIGDPSQLIGIYVLLGDGSRFRQPLGQDGVARFVDPDIQGPQDVTLLAVSTEKTFADTYLALEQPEVWLQQYTKEDTGGETGQATLKGRITGRTSVIQDVIVASADQQGHGNSTRAAIDGSFEIDISGSGVMPVHLFAMEYVNSTRRFGLKSNITLQAGQTLDDVEIALDRAEDQFQQVNVENIEPYGTEALVTMDYKLGTMYLFRSMATGAPPLQLPSMLLTPPFDLLRVVTTVIVGSDGAAGVTSASATVLTEGGSSSVVTIPPPLQLTSIPLGTMEAPAVARTEGFTLAWSVVPTAQVVHAYLNAQSSDHQLVWRLTAPSNRTSFTPFELPAELSPVTRLPPGLASLSMSAKNNGADRAYADLFNQYESPIQQGGTWSLSRQGFVRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZT6</accession>
    <name>Q1CZT6_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF90928">
        <property type="protein sequence ID" value="ABF90928"/>
        <property type="gene ID" value="MXAN_5950"/>
    </dbReference>
    <dbReference type="GeneID" id="41363189"/>
    <dbReference type="KEGG" id="mxa:MXAN_5950"/>
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    </dbReference>
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    <dbReference type="OMA" id="ARYTPLY"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
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    </dbReference>
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        <property type="entry name" value="HD"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="431" mass="48558" checksum="9E8824D1B048260A" modified="2006-07-11" version="1">MRIRDPIHGTIAVSDPEKAVIDSRHYQRLRYVRQLGFGDLAFPGATHTRHIHSLGAMHVASRVFGAVAARSSLPEDVRERFCAAVRLAVLCHDLGHMPLSHASERIAPKRSLLRLPSWLDGTAEGELATHEDYTAKILLDSSLTPIIEKHFGGMGITPMAAVALVSGAKPPKDPGFTHQGVDWTPLLRAIVSGELDADRMDYLLRDSFYTGVNYGRYDMDWIVSNLNPAMKDGRAYLALSRAAAFAFEDFLLSRYHMFVSVYLHHTSVNFDYMLRRYYEESPGEFEIPSDPEEFLLCDDSALWYTLRRSKNPWAQRISQRQGYKLLAQFTERDTGYDLDVLRSALVSHKFDHYVVESQNVLSKYTSGPSGRGPSLYIIDASTGRLTEVARYTPLYQRYSGAVRLVRLYVRPDQADKAHALMGRVLGQAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY5</accession>
    <name>Q1CZY5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89964">
        <property type="protein sequence ID" value="ABF89964"/>
        <property type="gene ID" value="MXAN_5901"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5901"/>
    <dbReference type="HOGENOM" id="CLU_2423866_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="9103" checksum="190C9409D4F1CC4A" modified="2006-07-11" version="1">MVGTEILRERCGSGPPGCGGLGEDGVPSGGGARREQGARASRNDGAHQPSRVDGLDGSPGSDGHQPNLEGESPPGIDIRHMAFSDVIGANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D086</accession>
    <name>Q1D086_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial pre-peptidase C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5800"/>
    <dbReference type="EnsemblBacteria" id="ABF92938">
        <property type="protein sequence ID" value="ABF92938"/>
        <property type="gene ID" value="MXAN_5800"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296791_0_0_7"/>
    <dbReference type="OMA" id="GNCDVPV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187951" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1016" mass="103550" checksum="0B3A19DBEF99E382" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0U7</accession>
    <name>Q1D0U7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555541.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87083">
        <property type="protein sequence ID" value="ABF87083"/>
        <property type="gene ID" value="MXAN_5587"/>
    </dbReference>
    <dbReference type="GeneID" id="41362833"/>
    <dbReference type="KEGG" id="mxa:MXAN_5587"/>
    <dbReference type="eggNOG" id="ENOG5031AZD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635716_0_0_7"/>
    <dbReference type="OrthoDB" id="814381at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188081" evidence="1">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="403" mass="45034" checksum="12F94A395F0F1A7F" modified="2006-07-11" version="1">MLAPAVSLACALLLAQPGNEAPVLQPPTTPLPAQAWHAPTVCLRLPPTNNVPSGEWRAQCDDTAQACRVSPLRELDAEGVETDRLQARVTTCSIAFDEETAERVKGYRMEPARAAAPPGWYRDERGRVMQFNFDLNRRVWLGGAWAPLWHDGQVQGRMRADFGIAVEAPSHRGKRLHRLRFLETELHLGVPSLDLTAARYDFSVERDDPLFRVTTFFGKPRRHDLHLNLGLWMETLRVEELERGGEVGRFLTWGTLHATVDLWHSKDLVSYVRVRAGPSFERDYANGFNTFVPGAALEADLTLDQDGFHHLRLGVEAEKVLLAPAVVGRPLRPERLRLQAGYEVIILAINDQPLSLLVDGRGMKRGDIAGVPEQWEWSASAGLRFSLWAPARRSAPMATSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D123</accession>
    <name>Q1D123_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555465.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5507"/>
    <dbReference type="EnsemblBacteria" id="ABF88815">
        <property type="protein sequence ID" value="ABF88815"/>
        <property type="gene ID" value="MXAN_5507"/>
    </dbReference>
    <dbReference type="GeneID" id="41362761"/>
    <dbReference type="KEGG" id="mxa:MXAN_5507"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318275_0_0_7"/>
    <dbReference type="OMA" id="RHIEGRF"/>
    <dbReference type="OrthoDB" id="61100at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="806"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="975" mass="106003" checksum="5C0B8AB00807D4AA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1A8</accession>
    <name>Q1D1A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555380.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90299">
        <property type="protein sequence ID" value="ABF90299"/>
        <property type="gene ID" value="MXAN_5418"/>
    </dbReference>
    <dbReference type="GeneID" id="41362680"/>
    <dbReference type="KEGG" id="mxa:MXAN_5418"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082381_1_0_7"/>
    <dbReference type="OMA" id="TLPGGWC"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="23542" checksum="D16C6819534B4D61" modified="2006-07-11" version="1">MTEPNWLNWTRELQAIAQTGLAFARDPYDRERYEMLRALASQIMAEHTTAPAERIESLFEGESGYATPKVDVRAAVFDEQGRVLMVREISDGGAWTLPGGWADVNLTPAENVIKEVREESGFEVRVRKLAAVWDRNRQGHPPAVFSCCKFFFICELVGGTAATSVETSEVGWFREDELPDDMSLARVLPGQVRRMFMHARDAALPTDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1M4</accession>
    <name>Q1D1M4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5298"/>
    <dbReference type="EnsemblBacteria" id="ABF86028">
        <property type="protein sequence ID" value="ABF86028"/>
        <property type="gene ID" value="MXAN_5298"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5298"/>
    <dbReference type="HOGENOM" id="CLU_3236411_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="43" mass="4585" checksum="1FE883FB2E7852E6" modified="2006-07-11" version="1">MLSVQPPDIANTPNVNVRIHRMGTSSTGEPGCQCKTGAEARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U1</accession>
    <name>Q1D1U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">MXAN_5230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555197.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5230"/>
    <dbReference type="EnsemblBacteria" id="ABF92827">
        <property type="protein sequence ID" value="ABF92827"/>
        <property type="gene ID" value="MXAN_5230"/>
    </dbReference>
    <dbReference type="GeneID" id="41362511"/>
    <dbReference type="KEGG" id="mxa:MXAN_5230"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_7"/>
    <dbReference type="OMA" id="VCADEAP"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="45816" checksum="32686D6C4B5A99F1" modified="2006-07-11" version="1">MTFASLGLSDALTRAVAGLGYDEPTPVQRATIPVVLRGGDVWASAKTGSGKTAAFLLPILEALRARPGGSVRPVRAFILVPTRELAAQIVDSIQRYGQHLKKPLKTCLAVGGVSANPQMLALRGGADIVVATPGRALDLVHQNALRLDQVETLVLDEADRLFSLGFADELNSLLALLPTRRQNLLFSATFPPAVRKFAEQLLHEPTRIDVDDGELPSTEFILQRALQVDVPRRTMLLRHLLETHAWSHVLTFVASRYTADHVALKLNRAGIVATSLHGELSQGARTRALADFKAKRVRVLVATDVAARGLDIAQLPAVVNYDLPRSTADYVHRIGRTGRAGDKGVAISFVSAGTEAHFRLIEKRHQLDLPREQVPGFEPTEEVSTTTPPRDPNGGVKGRRKSKKDKLREAAAAAATRPPKQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D207</accession>
    <name>Q1D207_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555134.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5163"/>
    <dbReference type="EnsemblBacteria" id="ABF91723">
        <property type="protein sequence ID" value="ABF91723"/>
        <property type="gene ID" value="MXAN_5163"/>
    </dbReference>
    <dbReference type="GeneID" id="41362446"/>
    <dbReference type="KEGG" id="mxa:MXAN_5163"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_2_0_7"/>
    <dbReference type="OMA" id="ICYTIID"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023293">
        <property type="entry name" value="dGTP_triP_hydro_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027432">
        <property type="entry name" value="dGTP_triphosphohydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="59"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="472" mass="52433" checksum="978E3919D9C8F9CD" modified="2006-07-11" version="1">MGSEKKPVEEPAPVLSDMDALLQDERTDYDRDYDRIVFSAEFRCLHDKTQVFPLSTSDYTRTRLTHSIEASCVGRSLGNLAGRGLRARDVMVNPSHLGTIVAAACLAHDIGNPPFGHSGEAAIQHWVSQRLARPGAEVDGRKSPFETVEQWQDLEAFEGNAQGFRILNRLQSRERRGGLRYTAATLGAMSKYPRASVLPGGRERDKGRVSEKKFGYFQDDEALALEAYRAVGLVEREAGVFSRHPLAFLVEAADDICYAVIDLEDSAKLGLIPIKDACELLDAVLPKLVKGPVRPPPSHPETRLAQARARAIGELIQASVKVFLENVEAMEDGKWETPLASARDDVAKPLKAIRNLTRRYGYESERVLQIESAGFKTLGGLLDMFAMAVVTDTPNREEKKLRQLLPLDLFQRPEHVRDMAEEPASRDEAITEAVARLSKYQRLLCVTDYISGMTDGFAVELFQRLSGIKLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D270</accession>
    <name>Q1D270_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555073.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5099"/>
    <dbReference type="EnsemblBacteria" id="ABF89468">
        <property type="protein sequence ID" value="ABF89468"/>
        <property type="gene ID" value="MXAN_5099"/>
    </dbReference>
    <dbReference type="GeneID" id="41362383"/>
    <dbReference type="KEGG" id="mxa:MXAN_5099"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_2_0_7"/>
    <dbReference type="OMA" id="EKWVLHI"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="138" mass="15267" checksum="3BA30D1CEA56B4CD" modified="2006-07-11" version="1">MSANKRPGPLARKMAKLAVERGNLYVPSCPSRGVLDHVTSRWGVLVLIALLEGTRRFSELRRRVAGVSEKMLSQTLQALEQDGFVLREVHPVIPPHVDYSLTPLGEEVAARVEALADWIEDSMPRIAAARAVYTPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2C5</accession>
    <name>Q1D2C5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555019.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5043"/>
    <dbReference type="EnsemblBacteria" id="ABF91124">
        <property type="protein sequence ID" value="ABF91124"/>
        <property type="gene ID" value="MXAN_5043"/>
    </dbReference>
    <dbReference type="GeneID" id="41362328"/>
    <dbReference type="KEGG" id="mxa:MXAN_5043"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009287_0_0_7"/>
    <dbReference type="OMA" id="RIELCNE"/>
    <dbReference type="OrthoDB" id="907030at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043543">
        <property type="entry name" value="PAPPA/PAPPA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130">
        <property type="entry name" value="PTHR46130"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13948">
        <property type="entry name" value="DUF4215"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188167" evidence="4">
        <location>
            <begin position="24"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1118" mass="113199" checksum="156F273C78A1149E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F5</accession>
    <name>Q1D2F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90057">
        <property type="protein sequence ID" value="ABF90057"/>
        <property type="gene ID" value="MXAN_5013"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5013"/>
    <dbReference type="HOGENOM" id="CLU_509794_0_0_7"/>
    <dbReference type="OMA" id="NDASTHM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="558" mass="59612" checksum="8E77D5CEB1416642" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2J0</accession>
    <name>Q1D2J0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554955.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4977"/>
    <dbReference type="EnsemblBacteria" id="ABF89337">
        <property type="protein sequence ID" value="ABF89337"/>
        <property type="gene ID" value="MXAN_4977"/>
    </dbReference>
    <dbReference type="GeneID" id="41362262"/>
    <dbReference type="KEGG" id="mxa:MXAN_4977"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="NGNRTHT"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="149"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="49463" checksum="FA07FE3B03901146" modified="2006-07-11" version="1">MSAPHPLLLVDDDAAFRKVYGGLLRDAGYEVVEAADRPSARAAFDARDFPLVLLDLMLPPDGSVSAGLEGLAALLSAKPGTKVIVVSGAGDTRHTLEAVRLGAYDFLTKPVDPDVLLVVVQRALARVTLERQVETLRSSLTRAAGGVSLVGQSASFLAATSLAERVAASELPVLVTGENGTGKELLARTVHLKSRRHDGPFVPINCGALPESLLESALFGHVKGSFTGATKDHRGLFAEADGGTLFLDELGDMSPSLQVKVLRALETGDILPVGADRPVQVDVRLISATHQDLGRMLQEGAFREDLYWRVKGVEIRLPPLRERSADLPLLAKHFLNQCAHLCPDGRARLLSDAAAEALLAHAWPGNLRELRHEMQRATVLAGERREIQPEDLSFTGSERLHATRAPGTTTLAQKVEALERREIEEALRRLNGNRTHTAEALGLSRQGLLKKLERFGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2J1</accession>
    <name>Q1D2J1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554954.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4976"/>
    <dbReference type="EnsemblBacteria" id="ABF92534">
        <property type="protein sequence ID" value="ABF92534"/>
        <property type="gene ID" value="MXAN_4976"/>
    </dbReference>
    <dbReference type="GeneID" id="41362261"/>
    <dbReference type="KEGG" id="mxa:MXAN_4976"/>
    <dbReference type="HOGENOM" id="CLU_1155439_0_0_7"/>
    <dbReference type="OMA" id="GWRVADT"/>
    <dbReference type="OrthoDB" id="1200805at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188056" evidence="1">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="24934" checksum="E93A08E3E51B51DD" modified="2006-07-11" version="1">MMRPGCFGPLVSALLLVSLESAAQAPAPAPADETPRVTTSDTALLRGTSEDPLGAVLAPVTLPDGATALYGFVGAPEIGVGFRQGISGFELEARARLQWFQLSASLELAVRRKVLEQGILSLAPTLGLGVVLNSGATYMDDRNYSGVLFRVSPGLVAGWRVADTVSVLGLLDVPVDIGLSNGQSRRIQALGGGGVEVYLGSNLSALAAGQLGVESFQERSGESHTRLGYSVRLGLGVRLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2S2</accession>
    <name>CH10_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">MXAN_4894</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002640434.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D2S2"/>
    <dbReference type="SMR" id="Q1D2S2"/>
    <dbReference type="STRING" id="246197.MXAN_4894"/>
    <dbReference type="EnsemblBacteria" id="ABF89063">
        <property type="protein sequence ID" value="ABF89063"/>
        <property type="gene ID" value="MXAN_4894"/>
    </dbReference>
    <dbReference type="GeneID" id="41362184"/>
    <dbReference type="KEGG" id="mxa:MXAN_4894"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_7"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025308" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <sequence length="96" mass="10650" checksum="6A4408E6E3F45EA0" modified="2006-07-11" version="1">MKIRPLQDRLIVKRVAEENKTKGGLFIPDTAKEKPLEGKVIAVGNGKVQEDGKVRPLDIKAGDTILFSKYAGTEIKLDGEEHLILREEDVLGVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D330</accession>
    <name>Q1D330_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4781"/>
    <dbReference type="EnsemblBacteria" id="ABF89968">
        <property type="protein sequence ID" value="ABF89968"/>
        <property type="gene ID" value="MXAN_4781"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4781"/>
    <dbReference type="eggNOG" id="COG4272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140339_2_0_7"/>
    <dbReference type="OMA" id="FFRHPDY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="15955" checksum="FA621BED1AB36B1A" modified="2006-07-11" version="1">MSEAPKLEPRSLEAVTAAVQDGEDASLLHPELLISDLLRYGVAASLALVTLGTVVTFFRHPDYLVSSEALLRLTSPHPVPHTLGDVVAGALAARGQAFVMAGLLVMMAVPVMRVALSLLIFRQQKDRLYVGITATVLAMLVLSFLLGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D358</accession>
    <name>Q1D358_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheR</name>
        <name evidence="8" type="ORF">MXAN_4753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4753"/>
    <dbReference type="EnsemblBacteria" id="ABF90193">
        <property type="protein sequence ID" value="ABF90193"/>
        <property type="gene ID" value="MXAN_4753"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4753"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_1_7"/>
    <dbReference type="OMA" id="GKMDVIF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="33863" checksum="16C3E87C46D3AE15" modified="2006-07-11" version="1">MARFDDGRPEMSAEEFRLLRDHVYSHCGILVHEDMKFVMERRLWPRLELLGLPDYGAYHRYLRYDANRHAELEAAVESLTTHETYFFREPTQLKAFTDELLPVVGQRNARLRRLRVWSAGCSSGEEAYTLAMLLKDSRRFDDWDVEVLGTDISRRVLAMARRAEYGPSALRATSPELLERHFVSLGNSRVRVRDEVRAWVSFGHHNLLDEVGSQLVPRMDVVFCRNVLIYFDLAARRKFLRIVRDRLVPGGYLLLGHSENLLNLGSDFEFVHLRGDLVYRRPELDEGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3I3</accession>
    <name>Q1D3I3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-antigen ABC exporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ORF">MXAN_4622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554617.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4622"/>
    <dbReference type="TCDB" id="3.A.1.103.4">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91603">
        <property type="protein sequence ID" value="ABF91603"/>
        <property type="gene ID" value="MXAN_4622"/>
    </dbReference>
    <dbReference type="GeneID" id="41361922"/>
    <dbReference type="KEGG" id="mxa:MXAN_4622"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_1_7"/>
    <dbReference type="OMA" id="ICPKSIL"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="37"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="69"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="47617" checksum="FE4D443198459109" modified="2006-07-11" version="1">MPESMDAIILKDVVKSFRKRTIRGEYTTFKSELLRWLRGKRQSRDASLITALRGINLTIPKGKTVGIIGRNGSGKSTLLKLITGIYTPTSGDLQINGRISALLDLGAGFHPDFSGRENILINGIILGMTRAEVRARMDEIIAFSELGEFIDEPVRTYSSGMYMRLAFAVATHVDPDILIIDEILAVGDEHFSKKSLAKMMDFKRQGKTIVLVTHELGTVERWCDLAAWIDGGYVRRVGKPSEVTAEYREAISLAEAQSAAFTPPALTEGGGALPQVPSESLPAEGPVRIHRVQLLDARGESLEVLSPEEGLEVRADFSVEGPCEDVDFHVRLQAADGRTLYETSTRSEAVVLSRMPNPGVLRFVVERLGALGGDYSLVVSARASKGESSGRCAFRVVSATEEEGVFRPPHRWLVEPGANSQAGVPFEPGTSPRVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D436</accession>
    <name>Q1D436_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnosyl O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rhamnosyl O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554415.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4416"/>
    <dbReference type="EnsemblBacteria" id="ABF89459">
        <property type="protein sequence ID" value="ABF89459"/>
        <property type="gene ID" value="MXAN_4416"/>
    </dbReference>
    <dbReference type="GeneID" id="41361729"/>
    <dbReference type="KEGG" id="mxa:MXAN_4416"/>
    <dbReference type="eggNOG" id="COG3510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063868_0_0_7"/>
    <dbReference type="OMA" id="IIQMPAD"/>
    <dbReference type="OrthoDB" id="1831745at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007072">
        <property type="entry name" value="Rhamnosyl_O-MeTrfase_CmcI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04989">
        <property type="entry name" value="CmcI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="24044" checksum="E3BBE4261D3A0A1A" modified="2006-07-11" version="1">MKQIIDDFHALYFGALVTREYHGGGERWMGVPIRKVPHDLWIYQEILHETRPDLIIETGTMFGGSALYFAHLCDLLGHGQVISIDLDQRESVPRHHRIEYMQGSSVAPEILERVRGRIAPGTRTMVVLDSDHSAEHVLQELRLYSPLVSPGHYLIVEDTNIGHPLHTFQVERGPMEAIEAFLPTAPDFERDSSREKLLFTSNPGGFLKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D447</accession>
    <name>Q1D447_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554404.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4404"/>
    <dbReference type="EnsemblBacteria" id="ABF92666">
        <property type="protein sequence ID" value="ABF92666"/>
        <property type="gene ID" value="MXAN_4404"/>
    </dbReference>
    <dbReference type="GeneID" id="41361717"/>
    <dbReference type="KEGG" id="mxa:MXAN_4404"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_7"/>
    <dbReference type="OMA" id="WFALTFW"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="442" mass="45682" checksum="A44FDE037DC256A8" modified="2006-07-11" version="1">MTAAPSFPMKSAVVIWLGQVLSLLGSGLTSFALGVWTYKTTGDVTQYALVMLSATLPAILLGPVAGALVDRWNRRWVLVLSDAAAGLSSLVLALLLFNDLLQPWHAYVTTAVVSTASAFQQPAFGVLVSTVVPPQHLGRANGLVQVGLAFSQLVAPMLSATLMELIELKGILLIDATTLVLGALPLLLARIPREHLVSSSGEERVPLLEAIRAGGAYLRATPGLLALIGFLAASNFLTGTVEVLVTPLVLSFADVRTLGALTTAGGVGMLAGSLVISAWGGPKRLMNGLLGFQLTCGLALICVGLATSVPVLAGVAFAFFFGLPIINGSSQTLLQRIVPLALRGRVFAFTSTITGAMLPLAYTIAGPLADHAFEPAMASGGKLVPLLGAFVGEGPGRGIALMFLIAGVLAVLMTLLATLYRPLRELDVPPQDAPSAEPAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4K5</accession>
    <name>Q1D4K5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Y8</accession>
    <name>Q1D4Y8_MYXXD</name>
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        <submittedName>
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    </gene>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4107"/>
    <dbReference type="EnsemblBacteria" id="ABF91078">
        <property type="protein sequence ID" value="ABF91078"/>
        <property type="gene ID" value="MXAN_4107"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_4107"/>
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    <dbReference type="OrthoDB" id="95925at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188140" evidence="1">
        <location>
            <begin position="22"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="554" mass="58717" checksum="E71758D7EE1F4867" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D501</accession>
    <name>Q1D501_MYXXD</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_4094"/>
    </dbReference>
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    <dbReference type="OMA" id="NCPAVEG"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="ABF92874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="101" mass="10322" checksum="47605D450B225DBE" modified="2006-07-11" version="1">MEVPTGEVLDIARSGENLTSRLAGVPVRGTITTQGTFLMTGTGVPSANRTDTLTLTGSYLAPLTDGGTASINGVLTGSYVRASDTGGQRCNVNSPFSATRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5F1</accession>
    <name>Q1D5F1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[Acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fabD</name>
        <name evidence="5" type="ORF">MXAN_3942</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3942"/>
    <dbReference type="EnsemblBacteria" id="ABF91606">
        <property type="protein sequence ID" value="ABF91606"/>
        <property type="gene ID" value="MXAN_3942"/>
    </dbReference>
    <dbReference type="GeneID" id="41361274"/>
    <dbReference type="KEGG" id="mxa:MXAN_3942"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_412620_0_0_7"/>
    <dbReference type="OMA" id="QMGRELY"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="PKS_AT" evidence="4">
        <location>
            <begin position="18"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="4">
        <location>
            <begin position="367"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="657" mass="71808" checksum="4429E4338EFA0F8A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5F3</accession>
    <name>Q1D5F3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">MXAN_3940</name>
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    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
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    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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        <property type="protein sequence ID" value="ABF86745"/>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_3940"/>
    <dbReference type="eggNOG" id="COG1024">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="29232" checksum="C5F28442AD0A96E7" modified="2006-07-11" version="1">MQAASPPHRDYQTLRVRFEAQTCFLQLHRPDADNTISRTLIDECQQVLTLCEEHATTVVLEGLPHVFCMGADFRAIHDRVDDGRREQGNAEQLYRLWLQLATGPYVTVAHVQGKANAGGLGFVAACDIVLAKAEVQFSLSELLFGLFPACVMPFLARRIGIQRAHYLTLMTRPIDAAQALSWGLADAVDADSEKLLRLHLRRLRCLSKPAVTQYKKYASELGGQLLAAMPRAISANEAMFSDRATLEAIHRYVETGRLPWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5G7</accession>
    <name>Q1D5G7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553936.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3926"/>
    <dbReference type="EnsemblBacteria" id="ABF89626">
        <property type="protein sequence ID" value="ABF89626"/>
        <property type="gene ID" value="MXAN_3926"/>
    </dbReference>
    <dbReference type="GeneID" id="41361257"/>
    <dbReference type="KEGG" id="mxa:MXAN_3926"/>
    <dbReference type="eggNOG" id="ENOG50332HJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946033_0_0_7"/>
    <dbReference type="OMA" id="WTEYLFA"/>
    <dbReference type="OrthoDB" id="2110857at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="31529" checksum="1F5B6B18FCD3522D" modified="2006-07-11" version="1">METVLYSLTSVLLRSGNSVFDRLSYGLRRQSILVLNFANNFVPFLLLAALTPLLPMTDRAGWALYGNARLALFAVSVQGVAFAFSYGFRHLTVARVNIASRIGDVLIPLALMLSGRTVHWTEYLFALAVSGCSLLAAGGGSDSRRALWLPAFFITVAVLVQSLCGELFFQGQPSGVASNLEVSTALMFWRSAACLVLLLLFGARGTLGAQLSELVVDGRARTNLLVRALFTVGNQVAFVMALAAGNRVVAWPILNSVTLFSLVFANAFIQEAPARREVFAVVAIVALAVLKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V9</accession>
    <name>Q1D5V9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553795.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3782"/>
    <dbReference type="EnsemblBacteria" id="ABF91758">
        <property type="protein sequence ID" value="ABF91758"/>
        <property type="gene ID" value="MXAN_3782"/>
    </dbReference>
    <dbReference type="GeneID" id="41361114"/>
    <dbReference type="KEGG" id="mxa:MXAN_3782"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_16_0_7"/>
    <dbReference type="OMA" id="QKGERLC"/>
    <dbReference type="OrthoDB" id="1456354at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="16113" checksum="E5AFF89E2478E74F" modified="2006-07-11" version="1">MALVPATTLKACPLFKGFTDTGIQIFAGVAVTRAFPKGTVLFAEGKTGESLLIVGEGTVRLSGKSAGGEDVSLGEVGSGEPLGELALVQKGERLCTATAVTDVSALEIRAADFQKLLATKPQACVKLLMGIVAHFGQKARDNRDMLRTLIGKAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Y3</accession>
    <name>Q1D5Y3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553771.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3758"/>
    <dbReference type="EnsemblBacteria" id="ABF89442">
        <property type="protein sequence ID" value="ABF89442"/>
        <property type="gene ID" value="MXAN_3758"/>
    </dbReference>
    <dbReference type="GeneID" id="41361090"/>
    <dbReference type="KEGG" id="mxa:MXAN_3758"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107533_0_0_7"/>
    <dbReference type="OMA" id="WMAKGIA"/>
    <dbReference type="OrthoDB" id="1825736at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13065" checksum="8C7DEF28EB5F5FFC" modified="2006-07-11" version="1">MFAAKKGKWMAKGIARSELYRKWLAHKLINDLPRVARNRWDDFEPDDVLRHVGLTTYKPARAGLGGLGIFLLGVAAGGVAALLLAPKTGTELRTTVKDKATAYMNKQNVNMGQERTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D639</accession>
    <name>Q1D639_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553715.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3697"/>
    <dbReference type="EnsemblBacteria" id="ABF86905">
        <property type="protein sequence ID" value="ABF86905"/>
        <property type="gene ID" value="MXAN_3697"/>
    </dbReference>
    <dbReference type="GeneID" id="41361032"/>
    <dbReference type="KEGG" id="mxa:MXAN_3697"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_1_1_7"/>
    <dbReference type="OMA" id="PWHISFR"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="25990" checksum="966BB76A492262A0" modified="2006-07-11" version="1">MLIDMHAHSHLSKGCELDPRAVLERAALFGLDGVAFTETNTQDGCDELFEIGAKSKLKVFVGLELVTDRGQYLCFFPKPELAPEPVQMWGSNREKPWSAAECLPKVKALGAAIVAARPYDRDSQNPAMDFIRSLGVLSAVEGYNARVKQTSNDLAVEAAAALKLPCVGGSDARGSLDEVGRGATLFKRPVQTQAELVAELQKGDFWPVMAGDLPRLTRPGEAQAARKSGGGGRGGGGKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D646</accession>
    <name>Q1D646_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553708.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3690"/>
    <dbReference type="EnsemblBacteria" id="ABF89314">
        <property type="protein sequence ID" value="ABF89314"/>
        <property type="gene ID" value="MXAN_3690"/>
    </dbReference>
    <dbReference type="GeneID" id="41361025"/>
    <dbReference type="KEGG" id="mxa:MXAN_3690"/>
    <dbReference type="HOGENOM" id="CLU_865235_0_0_7"/>
    <dbReference type="OMA" id="CGASHSH"/>
    <dbReference type="OrthoDB" id="946621at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188307" evidence="2">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="34762" checksum="EBDE4191687163FB" modified="2006-07-11" version="1">MRRPSWKLSSWALMGTFAAGCGASHSHVTWSEDAPHPKEEVFVARPPPEPPAPSPTSDPKAFAARYANPSVCEAAARRLQGASRDEAWDGLKACIEHTPFTQLNALLGRAWAQDLRVRPEGAKLIARVVAQRGGSVTGELRYLQEKQIPIFSLASAMDRPDTYKGRYVLLRAQVADQRSEGERPTVWLVEQALSSVQTDEVVGYGERIDSVTTYSGDLAGQSVLTGPGRIGGSVSTSERSGRNTTRRFVENISDETGREALGRLASADPFLETRRDYVILARFDGVRLTSGGAETDDEAPRIPVLTIVSYHAPQALVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D680</accession>
    <name>Q1D680_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3656"/>
    <dbReference type="EnsemblBacteria" id="ABF90529">
        <property type="protein sequence ID" value="ABF90529"/>
        <property type="gene ID" value="MXAN_3656"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3656"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280035_0_0_7"/>
    <dbReference type="OMA" id="GWQEVTF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025141">
        <property type="entry name" value="DUF4082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13313">
        <property type="entry name" value="DUF4082"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4082" evidence="1">
        <location>
            <begin position="74"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="1">
        <location>
            <begin position="236"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="1">
        <location>
            <begin position="409"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1154" mass="120930" checksum="ED9A58D8E88C1342" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D2</accession>
    <name>Q1D6D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3603"/>
    <dbReference type="EnsemblBacteria" id="ABF90121">
        <property type="protein sequence ID" value="ABF90121"/>
        <property type="gene ID" value="MXAN_3603"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3603"/>
    <dbReference type="eggNOG" id="ENOG502Z9WJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069764_1_0_7"/>
    <dbReference type="OMA" id="LRFWHVR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025534">
        <property type="entry name" value="DUF4420"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14390">
        <property type="entry name" value="DUF4420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="37997" checksum="3F78C1DFD2141C03" modified="2006-07-11" version="1">MGTTIWESDVKSVEEAWRLISEEPKLQAGLVARRLYPESRLEIYAGLDRPSDVPLVCIHVRPAALRMAGERLSSAGFVLLREINPHPSPNSVRLSLWLAAPPYRDVFGVLAQDVVDSVAKAVGQRNAVSTFVERLRRWQEFLERHGPEGLGAHAQRGLYGELWCLRHQALRLMGAECAILAWTGPDRSNQDFQFASCAVEVKTTASSPHHHVAISNIRQLDETHVPALLLLHVALEIRHDSGETLVGMVASLRDLLRPSGQPLSLFEEKLRSWGYLDVHAVRYGEAAYVVRSHDFYRVMGCFPRLTEADIPDGVGDVRYSVALSACAAYRLSPDAAAALIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6G4</accession>
    <name>Q1D6G4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553595.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3569"/>
    <dbReference type="EnsemblBacteria" id="ABF90477">
        <property type="protein sequence ID" value="ABF90477"/>
        <property type="gene ID" value="MXAN_3569"/>
    </dbReference>
    <dbReference type="GeneID" id="41360914"/>
    <dbReference type="KEGG" id="mxa:MXAN_3569"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_12_0_7"/>
    <dbReference type="OMA" id="IYIDYFY"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="99"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="35599" checksum="CF9D12D3A39075C2" modified="2006-07-11" version="1">MVYGFWVSRSLQIMAELELADTIGDTPKTVEELAEASGTHAPTLRRLLRLLSGLGVLVKDESTQRWALTELGGMLRKDNPGSVYGSLRAHGHILSWQAWGDLVTALKTGKPTVEKFMGDTFFNYMTTHPDVAAIFNGSMAAYQTLNAPAVVNGYDFSSARSIVDVGGGTGMLLTHILKANPGVRGTVFEMPHVAVEARERIAEQGLSPRCDVVAGDFFECIVPEGKDVYILSQILHDWDDEQSLRILKCIRAAMRPDSRLLIVETVLPGDNVPHFGNLYDLAMLVLVGGRERTGPEYTALLEKAGLRLFNVFPTTMPPSVVEAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D710</accession>
    <name>Q1D710_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553399.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3366"/>
    <dbReference type="EnsemblBacteria" id="ABF87416">
        <property type="protein sequence ID" value="ABF87416"/>
        <property type="gene ID" value="MXAN_3366"/>
    </dbReference>
    <dbReference type="GeneID" id="41360714"/>
    <dbReference type="KEGG" id="mxa:MXAN_3366"/>
    <dbReference type="eggNOG" id="COG2370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043645_3_0_7"/>
    <dbReference type="OMA" id="YWMVERA"/>
    <dbReference type="OrthoDB" id="760572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032809">
        <property type="entry name" value="Put_HupE_UreJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13795">
        <property type="entry name" value="HupE_UreJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188230" evidence="2">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="37878" checksum="CA95776E2046C8A9" modified="2006-07-11" version="1">MTWVSPRAMLACLLLAAGAAAAHDADILYIEAHRARAEAPEVRQILTMTPETLALLLADADGGSLLTRHGLDARRDAIATDIWDAMPLASGGLPCVRTAHATAPRQSFVELSATFTCPPGGMRQRFRVLTRLPPEYRVILGSVREGEVPGAVFADATRPEVDVPEGGRGTPLLSRFAGWVGLGVRHIFEGVDHLAFLLAVLLVGGGWRRVLLLVTSFTVAHSLTLGAAALGWVVLDGVQARWVEAAIAASIIYVAVENLVLREHRHRVLVTFLFGLIHGFGFAGVLAGYGLGESVVTALLGFNVGVELGQAVVVAVLLPVLRMVQRRPALHTRAVRGLSIGILAAGGYWMVERALG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D770</accession>
    <name>RL22_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">MXAN_3304</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002633603.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D770"/>
    <dbReference type="SMR" id="Q1D770"/>
    <dbReference type="STRING" id="246197.MXAN_3304"/>
    <dbReference type="EnsemblBacteria" id="ABF89495">
        <property type="protein sequence ID" value="ABF89495"/>
        <property type="gene ID" value="MXAN_3304"/>
    </dbReference>
    <dbReference type="GeneID" id="41360657"/>
    <dbReference type="KEGG" id="mxa:MXAN_3304"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_7"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000052613" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="114" mass="12590" checksum="DADC26EA8C46233D" modified="2006-07-11" version="1">MESTAHLRFLRMSPRKISTVAELIRGKPVEAALNILKFTKRAAAKPVEKLIKSAVANATDKSKGQVDVDTLYVKTISVDQGPTQRRFMPRAMGRATPIKKKTAHVHVVLAEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D2</accession>
    <name>Q1D7D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553287.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3242"/>
    <dbReference type="EnsemblBacteria" id="ABF87905">
        <property type="protein sequence ID" value="ABF87905"/>
        <property type="gene ID" value="MXAN_3242"/>
    </dbReference>
    <dbReference type="GeneID" id="41360595"/>
    <dbReference type="KEGG" id="mxa:MXAN_3242"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_4_1_7"/>
    <dbReference type="OMA" id="CKHHATE"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="375" mass="40239" checksum="BAD923A5342C1A64" modified="2006-07-11" version="1">MRTWMCWVFLACWALGVPALGVTVKEVPRLAANAWSVDTTRTLTPQTLAEVDQLGNALVRDGQGQLAVVVVDTTGRQPPRAFALELFNRWGLGTAGRDDGALLFIALEDRAAEIILGDGVDGPNEQARSDAIMANDVVPAFKRGSPDDAVLEGARGLHQLIVTSELNQPRNAQEAASAWDPRLAESAWSEDSAVTIGSEGPSEPEGDLNVPALAGGAGFVGAVGVAGRALLRRRPRRCQKCRNPRARLDEDADDAHLAPGQVREEQLGSVDYDVWWCEPCQDAVVERYGTLFTRHVRCTKCRYVTANKTSRTIRSATYSSGGEIEVTVRCTHCHHTATSRHSTPKLTRSTSSSSSSRSSSSSGGRSSGGGSSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7I7</accession>
    <name>Q1D7I7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553232.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3183"/>
    <dbReference type="EnsemblBacteria" id="ABF90072">
        <property type="protein sequence ID" value="ABF90072"/>
        <property type="gene ID" value="MXAN_3183"/>
    </dbReference>
    <dbReference type="GeneID" id="41360538"/>
    <dbReference type="KEGG" id="mxa:MXAN_3183"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_147_1_7"/>
    <dbReference type="OMA" id="DVEHIFV"/>
    <dbReference type="OrthoDB" id="1058607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="384" mass="41221" checksum="56151B263ADDE944" modified="2006-07-11" version="1">MSKAIEFKIPRGAILFSAGGVGYEYREDLGPAHHGMSLFVARLRAASGAPRGKVLLKAVPAPSETDGARVMRARAKLDEQVRLAAFLKHPAILKVHGLHKVEGYWYVSTEHPDGHSLNELLTLVGESQRWFSPLFVLYVGAQVAAALEHAHAAKDEQGRPLNIVHRAVDVEHIFVNWDGTVQLADFGLALSDLPGRVASSARGPLGDHFYSSPEMLLGGSVDARADLFTLGVVLLELATGKNLLFCPDDITPDVMASLPTKKRRRVARAVKRATLAGAPPLVADAIWRAATLTVADVDAMTEGLPQGLRVTLNRLLRVAPRERYQSAGELAADLTAWLGGTFAKADAAAELKSRPAQAEAALDSMATLPPRGRGKRKPDNVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J2</accession>
    <name>Q1D7J2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88685">
        <property type="protein sequence ID" value="ABF88685"/>
        <property type="gene ID" value="MXAN_3178"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3178"/>
    <dbReference type="HOGENOM" id="CLU_2991982_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="57" mass="5986" checksum="68198CB8582EB8AC" modified="2006-07-11" version="1">MGQRTSPLAHPKPKDPRNVNNALTKIATAQAAAGATCSKSRSSGRRRASRATQPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D821</accession>
    <name>Q1D821_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2993"/>
    <dbReference type="EnsemblBacteria" id="ABF89196">
        <property type="protein sequence ID" value="ABF89196"/>
        <property type="gene ID" value="MXAN_2993"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2993"/>
    <dbReference type="eggNOG" id="COG3330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336753_0_0_7"/>
    <dbReference type="OMA" id="GASDQQY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032585">
        <property type="entry name" value="DUF4912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16258">
        <property type="entry name" value="DUF4912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="784" mass="83841" checksum="F671E9D4675C648A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D854</accession>
    <name>Q1D854_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">MXAN_2960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D854"/>
    <dbReference type="STRING" id="246197.MXAN_2960"/>
    <dbReference type="TCDB" id="2.A.64.1.2">
        <property type="family name" value="the twin arginine targeting (tat) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92235">
        <property type="protein sequence ID" value="ABF92235"/>
        <property type="gene ID" value="MXAN_2960"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2960"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_5_4_7"/>
    <dbReference type="OMA" id="KTPSHQG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="92" mass="9461" checksum="912A13B3E3F0A142" modified="2006-07-11" version="1">MLLASSRRSRVMGLKGMEILLIMGVLLLLFGASRLPQLGSSLGSAIRNFKRGFGGEGEDAAAPGDKKGSGTLSSSTGVQNDVTKSQTPSGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D855</accession>
    <name>Q1D855_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553015.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2959"/>
    <dbReference type="EnsemblBacteria" id="ABF86270">
        <property type="protein sequence ID" value="ABF86270"/>
        <property type="gene ID" value="MXAN_2959"/>
    </dbReference>
    <dbReference type="GeneID" id="41360322"/>
    <dbReference type="KEGG" id="mxa:MXAN_2959"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_7"/>
    <dbReference type="OMA" id="PRIWTKF"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="620" mass="67304" checksum="8BA9937436D2FD67" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D6</accession>
    <name>Q1D8D6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552937.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2876"/>
    <dbReference type="EnsemblBacteria" id="ABF87969">
        <property type="protein sequence ID" value="ABF87969"/>
        <property type="gene ID" value="MXAN_2876"/>
    </dbReference>
    <dbReference type="GeneID" id="41360245"/>
    <dbReference type="KEGG" id="mxa:MXAN_2876"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007964_0_0_7"/>
    <dbReference type="OMA" id="EDDNHYF"/>
    <dbReference type="OrthoDB" id="14159at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188484" description="PepSY domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1201" mass="125779" checksum="D42C85160ED616A3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8V6</accession>
    <name>Q1D8V6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">purN</name>
        <name evidence="4" type="ORF">MXAN_2700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552768.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2700"/>
    <dbReference type="EnsemblBacteria" id="ABF92901">
        <property type="protein sequence ID" value="ABF92901"/>
        <property type="gene ID" value="MXAN_2700"/>
    </dbReference>
    <dbReference type="GeneID" id="41360078"/>
    <dbReference type="KEGG" id="mxa:MXAN_2700"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_1_7"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="23687" checksum="7E9783ABDB984B1B" modified="2006-07-11" version="1">MSGQRVRLGVLVSGSGSNLQALLDACAREDFPAEVACVVSNVSTAFALERARKAGVTAKVVDHKAHATKEGFEKALLDTLRAANVEWVCLAGFMRLLSADFLGHYAGRVLNIHPSLLPAFPGLHAQRQALERGVKVAGCTVHFVDAGTDTGPIIAQVAVPVLPDDDEKALSSRILAEEHRLYPLAVRLAVTGKVTLDAARTRVEARATVGELALRNPGATVDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D5</accession>
    <name>Q1D9D5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tldD</name>
        <name evidence="6" type="ORF">MXAN_2519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552590.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2519"/>
    <dbReference type="EnsemblBacteria" id="ABF86974">
        <property type="protein sequence ID" value="ABF86974"/>
        <property type="gene ID" value="MXAN_2519"/>
    </dbReference>
    <dbReference type="GeneID" id="41359896"/>
    <dbReference type="KEGG" id="mxa:MXAN_2519"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_7"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="139"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="256"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="493" mass="52239" checksum="B647774776368E68" modified="2006-07-11" version="1">MPRASAPSKRALSLKLAPPVARRPTPVALLPQPLVERLLAVAMERGGDFAEVYVERTLTTAVRLEESRIKSAQTGLVQGVGVRVISGGKVGYAFSDDWDESALLRAASTAVMIAQGGGAERSFPVRRAAVPSHYHVSPPLMDVEVSLKTGLLMRADKAARAFDARVKQVNGGYVDQTRRIAVANTHGRYTEDTQDLCRISVMVVAQGTGGERRTGMYGGGGRVPFSHWDTFSPEDVAREAARQAVATLGAVDCVAGPQTVVLAPGWSGILLHEAVGHGLEADFIRKGTSLFAGKLGEKVASDLVTIIDDGTVSSGRGSINIDDEGNPGERKVLIENGVLKGYLYDSLNAQLMGQRSTGSGRRESFKHLPMPRMTNTFLAPGDHAPEDILKEVKRGLYCATFGGGQVDITNGNFVFEVSEAYQIEDGKLGRPVKNATLIGVGPEALKNVSRVGCDPMPDPGMGICGKNGQSMPVGVGLPTVRIDNITVGGTKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9K6</accession>
    <name>Q1D9K6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FliP/MopC/SpaP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2447"/>
    <dbReference type="EnsemblBacteria" id="ABF92172">
        <property type="protein sequence ID" value="ABF92172"/>
        <property type="gene ID" value="MXAN_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2447"/>
    <dbReference type="eggNOG" id="COG4790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042028_2_0_7"/>
    <dbReference type="OMA" id="TEPFREF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005773">
        <property type="entry name" value="YopR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01102">
        <property type="entry name" value="yscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="25198" checksum="9947516A1F9DF6AF" modified="2006-07-11" version="1">MVNEAVNSDSFASRPLILILALAAMGLVPFALMMATSFVKISVVLSIVRSALGTQQIPPTQVITGLAIILTVYIMAPVGQQMYRAAGLDIWAKGPGVFSSETVGSMLGAANKSKEPLREWLIKKVTTKDRALFFNLAKKMRKGEDRDAVESNDFMVIIPAFVVSELKEAFQIGFLLFVPFIVIDMVVANILLALGMHMLSPTTISMPFKLLLFVLVDGWYLIAKGLVVGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9U2</accession>
    <name>Q1D9U2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552436.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88078">
        <property type="protein sequence ID" value="ABF88078"/>
        <property type="gene ID" value="MXAN_2361"/>
    </dbReference>
    <dbReference type="GeneID" id="41359746"/>
    <dbReference type="KEGG" id="mxa:MXAN_2361"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_2_7"/>
    <dbReference type="OMA" id="CHGVTEN"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="68"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="31364" checksum="A44A44F9F12E3ADC" modified="2006-07-11" version="1">MALAPLCVLLAAAGYLVVNGHRIGQGLLHPSPIPVTRPPAEPALSPLEDVAFTTSDGVPLKGWYVPSRNRAAVVLVHGFADNRAQLLFEARTLAGAGYGVLLFDLRAHGESGGDTVTWGDRERRDVTAALDFISRRPDVDPGRLGLFGFSMGGTTSLLVASEDARVKAVAAAGAYPALEADIYAGYGRWGAMSAEPVLWTLRRAGVTVDAVRPIDGMCRLGGRPLLLVNGDVDPDAPAKLQASLFQAACEPKSLWVVEGAGHGQYARVAPEEYARRLLQHFGAALQALPQASSGGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9U9</accession>
    <name>Q1D9U9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552429.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2354"/>
    <dbReference type="EnsemblBacteria" id="ABF91079">
        <property type="protein sequence ID" value="ABF91079"/>
        <property type="gene ID" value="MXAN_2354"/>
    </dbReference>
    <dbReference type="GeneID" id="41359738"/>
    <dbReference type="KEGG" id="mxa:MXAN_2354"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527758_0_0_7"/>
    <dbReference type="OMA" id="WYWREGM"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="191"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="517" mass="56775" checksum="A8DB8B5695986705" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z2</accession>
    <name>Q1D9Z2_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552386.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2311"/>
    <dbReference type="EnsemblBacteria" id="ABF91653">
        <property type="protein sequence ID" value="ABF91653"/>
        <property type="gene ID" value="MXAN_2311"/>
    </dbReference>
    <dbReference type="GeneID" id="41359698"/>
    <dbReference type="KEGG" id="mxa:MXAN_2311"/>
    <dbReference type="HOGENOM" id="CLU_1287721_0_0_7"/>
    <dbReference type="OMA" id="NNGSAWD"/>
    <dbReference type="OrthoDB" id="2094056at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188047" evidence="1">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="21605" checksum="0B2B19E723965883" modified="2006-07-11" version="1">MFRIAMVVALALSTFVGCGGDDDNPDGTPQKVQCDASNCAGCCFNNVCQTGTSTSACGKAGATCRACGTAQVCKADQTCGVDPEGVWRVQPVSAQIATSNNGSAWDADSSPPDVFVEMACPGGTSVFISDVVQSYTPAWTTAGCTARASQLMAEQWAFRLWDEDLASDDTITDVLGMRFTEQHFAAGTVTIGASGGMTSLTVQLQKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA00</accession>
    <name>Q1DA00_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2303"/>
    <dbReference type="EnsemblBacteria" id="ABF91559">
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        <property type="gene ID" value="MXAN_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2303"/>
    <dbReference type="HOGENOM" id="CLU_920785_0_0_7"/>
    <dbReference type="OMA" id="IALAPWE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="34591" checksum="0239575A630E781A" modified="2006-07-11" version="1">MRYSGRMTSSPPPPPGAVAFVDRWRELFDARDWSGLRAHEHPDFPEAGPPRQNDSFIRGLGTSGFRVTSATLKPFVQPRWSIFRTQRLHPQPTYWCDLVLKNAKGHETEAFIALAPWEGTEGAFRASYYVAIPPKKKVAPLDLGKERQRVAKFLAKAVKDFSRVQDARPLQRLELQYSTDNGTLNVSFDLDPAAEPGRGDAMTHFGFAELLVPRWADVKDHKPSLVGLDGAKLAAREDGTWGTPEAHAKLEEHLGKMLVATLLELRDSSQFEALRASATAELGVEEYEGHFGWPDYEERGRENRIASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA03</accession>
    <name>Q1DA03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552375.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2299"/>
    <dbReference type="EnsemblBacteria" id="ABF91195">
        <property type="protein sequence ID" value="ABF91195"/>
        <property type="gene ID" value="MXAN_2299"/>
    </dbReference>
    <dbReference type="GeneID" id="41359686"/>
    <dbReference type="KEGG" id="mxa:MXAN_2299"/>
    <dbReference type="eggNOG" id="COG5337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039171_0_0_7"/>
    <dbReference type="OMA" id="DWWIFNT"/>
    <dbReference type="OrthoDB" id="688261at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="579" mass="63440" checksum="704557D879717E78" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA58</accession>
    <name>Q1DA58_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552320.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2244"/>
    <dbReference type="EnsemblBacteria" id="ABF92314">
        <property type="protein sequence ID" value="ABF92314"/>
        <property type="gene ID" value="MXAN_2244"/>
    </dbReference>
    <dbReference type="GeneID" id="41359632"/>
    <dbReference type="KEGG" id="mxa:MXAN_2244"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_394235_0_0_7"/>
    <dbReference type="OMA" id="RYRWGDS"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="451"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="729" mass="77876" checksum="4B17F5D5E7978FB5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAA9</accession>
    <name>Q1DAA9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552269.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2191"/>
    <dbReference type="EnsemblBacteria" id="ABF86630">
        <property type="protein sequence ID" value="ABF86630"/>
        <property type="gene ID" value="MXAN_2191"/>
    </dbReference>
    <dbReference type="GeneID" id="41359582"/>
    <dbReference type="KEGG" id="mxa:MXAN_2191"/>
    <dbReference type="HOGENOM" id="CLU_1085141_0_0_7"/>
    <dbReference type="OMA" id="ELDYWDD"/>
    <dbReference type="OrthoDB" id="1378130at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="27677" checksum="41F2875087E40EB6" modified="2006-07-11" version="1">MRVLSSMAAIPRVLAMMFCLFGAQALASYATVLDGTVLLSADNTSRYLVAGGARFFIPSTQWSLYSSANLVVMSQSSIDAITQIPRDGTLAREKGQIAIYVFVGGMPWWIPNPTELDFWDDWKTINEIPSYWEAPFQDYSIQQVLLRERTGTQIYIWTTGLKIPITNASDLAYYGGESNVKTVPLGTLANHSDSEPYCGAILRERSSSTSYYLGYSAGLMRRYATTSAPHAVVPDGALSSFPVTTSGPYCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAC0</accession>
    <name>Q1DAC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase, coenzyme F420-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552258.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2180"/>
    <dbReference type="EnsemblBacteria" id="ABF86937">
        <property type="protein sequence ID" value="ABF86937"/>
        <property type="gene ID" value="MXAN_2180"/>
    </dbReference>
    <dbReference type="GeneID" id="41359573"/>
    <dbReference type="KEGG" id="mxa:MXAN_2180"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_0_2_7"/>
    <dbReference type="OMA" id="YYWERDG"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="24129" checksum="5B87B95485A701B8" modified="2006-07-11" version="1">MNIGIIGAGSIGATLARHLNALGHEISLANSRGVEGVTTIAASVGAKPVTVRDAAHAGPIVIVTIPQKAITDLPPGLFDDVPADVVVVDTGNYYPEFRDGHIGAIDAGQTDSEWVSAQLKRPVVKAFNNIQAGSLDTKGLPRGAPGRIALPVSGDDPRARQQILQLVDALGFDAIDAGPLSESWRQQPGTAVYCTDLDAEKLPKALAAADATKVAEVRRQNDLSVKAMFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAD8</accession>
    <name>Q1DAD8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552240.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2162"/>
    <dbReference type="EnsemblBacteria" id="ABF87555">
        <property type="protein sequence ID" value="ABF87555"/>
        <property type="gene ID" value="MXAN_2162"/>
    </dbReference>
    <dbReference type="GeneID" id="41359558"/>
    <dbReference type="KEGG" id="mxa:MXAN_2162"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715372_0_0_7"/>
    <dbReference type="OMA" id="ISAQMGH"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="386" mass="40479" checksum="4075F4047607989A" modified="2006-07-11" version="1">MKLDKPENLFAAIEQCDVFAVEDLLAKGADPDEVDLDGYQATPLAYACSHGDEAAVRALLDAKAAPDAAAFQPPLVAATAHGFAALVSLLVKAGADVNAGDETGASALWTAAANGFADIARCLVEAGADREQADNDGKLPSIVALENGHVALSNYLSDPASYPATHSFWRGSKKAARQAAEARRAQVVDRATGKDVRGAAAAEPEWTFSGGIARSPWATQDFPSVAAAGNLELVGRMLDAGLDPDWTQFKGNPTALMLAARSGELGAVDLLLARRAKVNHRTDKGLTALHMALFKPSARVHGPIIRSLLAAGADPNVPDDEGQRPLQRALAHAMPTLVQALIEAGADPFIRDRAGRMPADWAPTDGKHADAIRELLETARKGRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI6</accession>
    <name>Q1DAI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88764">
        <property type="protein sequence ID" value="ABF88764"/>
        <property type="gene ID" value="MXAN_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2110"/>
    <dbReference type="HOGENOM" id="CLU_2343774_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="97" mass="10060" checksum="E625B0674064B759" modified="2006-07-11" version="1">MYPQGGSISLSTGREHRSGGPVSGPPRPLRSSPHPQLGLYPAYTLEELVQGAPELVALPRHGQHLIATLHGALKAPDAVPPGNPLLPGARRLAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAJ4</accession>
    <name>Q1DAJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS66 family, truncated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2101"/>
    <dbReference type="EnsemblBacteria" id="ABF91039">
        <property type="protein sequence ID" value="ABF91039"/>
        <property type="gene ID" value="MXAN_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2101"/>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023034_5_2_7"/>
    <dbReference type="OMA" id="RHGQNER"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="2">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="12978" checksum="0AA9B41C0F14745D" modified="2006-07-11" version="1">MSSSRHHTTTLTLTRFVENERLPLDNNRSESALRKAALGRKNFLFVGHEAAGENLAGLYALVATCEANQVNPEEYLADVLLRVQTHPNSRIGELLPHEWKRRRVAEPPNAALQPSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAM2</accession>
    <name>RS15_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">MXAN_2072</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552156.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAM2"/>
    <dbReference type="SMR" id="Q1DAM2"/>
    <dbReference type="STRING" id="246197.MXAN_2072"/>
    <dbReference type="EnsemblBacteria" id="ABF91487">
        <property type="protein sequence ID" value="ABF91487"/>
        <property type="gene ID" value="MXAN_2072"/>
    </dbReference>
    <dbReference type="GeneID" id="41359480"/>
    <dbReference type="KEGG" id="mxa:MXAN_2072"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_7"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000255508" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="89" mass="10463" checksum="256E90A4CE84E720" modified="2006-07-11" version="1">MSLHQERKSELVSKFRTHESDTGSPEVQVALLSERITMLTEHFKTHKKDHHSRRGLLKLVGQRRRLLDYLKSKDVARYKKLIDGLGIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAX3</accession>
    <name>Q1DAX3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552055.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1965"/>
    <dbReference type="EnsemblBacteria" id="ABF87632">
        <property type="protein sequence ID" value="ABF87632"/>
        <property type="gene ID" value="MXAN_1965"/>
    </dbReference>
    <dbReference type="GeneID" id="41359376"/>
    <dbReference type="KEGG" id="mxa:MXAN_1965"/>
    <dbReference type="HOGENOM" id="CLU_936614_0_0_7"/>
    <dbReference type="OMA" id="EAWVMAG"/>
    <dbReference type="OrthoDB" id="1052317at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188371" evidence="1">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="32930" checksum="9E6F0C69CAA1A349" modified="2006-07-11" version="1">MRPGPLTSSLLLLLLATACSHKAPLSVSPSEPRPASVRLDFQPPVDRVLTETQRSVRSVERRGDTLREEVELTTQTRFTPSEGGWLLAQAVPRSRLTRNGQEVPTGVADVLARFTLQAWLAADGTFVKLVAPEAAQEALRQVAPSGTEAGVLERFFEPEALETRARREWEVKFAGLFQRNLVEGQQSWVVDLVPVGDSQVAYVLERTVQGTRDTPLGDAVVLGLRCLDAVPEDAPDALWEAWVMAGRPELTPGVSCEGEQLVGRGRFMPVSRQLTVRATVAGEAWTVTTESRAEGLQEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB57</accession>
    <name>Q1DB57_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage terminase, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551972.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1870"/>
    <dbReference type="EnsemblBacteria" id="ABF89678">
        <property type="protein sequence ID" value="ABF89678"/>
        <property type="gene ID" value="MXAN_1870"/>
    </dbReference>
    <dbReference type="GeneID" id="59387919"/>
    <dbReference type="KEGG" id="mxa:MXAN_1870"/>
    <dbReference type="eggNOG" id="COG4373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1494707_0_0_7"/>
    <dbReference type="OMA" id="FAEQEAH"/>
    <dbReference type="OrthoDB" id="1297392at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="21105" checksum="4AC6A84ED6E9CA6F" modified="2006-07-11" version="1">MAQDASDVPVPQGRLVAGFDVGRTRDRSELAVFEEVEGRFTCRLLKSFEGVPFAEQEAHLRRILSVLPVARLSVDRSGIGMNLAENLARDFPQVVEENFTNEAKERWATDFKILLQRRDVTLPRQRELVGQIHSIKRRVLPSGKVSFDAERTNRGHADKFWAVALACQRERGPERRGGTEIGVRVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB65</accession>
    <name>Q1DB65_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-like element pbsx protein xkdg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xkdG</name>
        <name evidence="2" type="ORF">MXAN_1862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551964.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1862"/>
    <dbReference type="EnsemblBacteria" id="ABF88252">
        <property type="protein sequence ID" value="ABF88252"/>
        <property type="gene ID" value="MXAN_1862"/>
    </dbReference>
    <dbReference type="GeneID" id="41359278"/>
    <dbReference type="KEGG" id="mxa:MXAN_1862"/>
    <dbReference type="eggNOG" id="COG4653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093819_0_0_7"/>
    <dbReference type="OrthoDB" id="556774at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024455">
        <property type="entry name" value="Phage_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05065">
        <property type="entry name" value="Phage_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01554">
        <property type="entry name" value="major_cap_HK97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="30889" checksum="1CF444CC2DB4F7E3" modified="2006-07-11" version="1">MSRLDNSTLLAKADLALADLTAGGGILQPAQAQKFMRLLIKQSVLLQQCTVVPMAAPKQQFSKLKFGSRILRPGQEATAVPAAQRVKPDLSQVELDAKLFKGEVRLSDEVLEDSIERGELRQTLMEMMADAISRDMEEILVNGDTASADPFLATMDGVLKQATSNVVDAAGAPISKDVLGDLLKSLPSEHLRDKSSMGFLLPASTRTWTTAARWRRGPRLSATSSSRATRLSSTRASRCGRFLSGRRTSARRMTARPSSCATPRISTSASGGRFGSSRRATSPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI4</accession>
    <name>Q1DBI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1739"/>
    <dbReference type="EnsemblBacteria" id="ABF91093">
        <property type="protein sequence ID" value="ABF91093"/>
        <property type="gene ID" value="MXAN_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1739"/>
    <dbReference type="eggNOG" id="ENOG502Z7QK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075514_0_0_7"/>
    <dbReference type="OMA" id="HDGLMDF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="31430" checksum="5CF502F3DD924555" modified="2006-07-11" version="1">MAPRGAPTHGAVEQAMGGASGLRDGTVDSPRVSRVSTRWRSPVLTVVLLSLLAVPPVEVEVFVPLCDNALIQCGRPPAGAPRALETNLYWGAMYGAERFLSRAPGFKMVSREPGPEGAAVLRELVLERTAAKGERPVRLRLRAYAGDAIDTALEDFLRAAAGASRADLLVWAGHDRLMDREPPRVDAPPGATPRPVVVLACMSEQYFGPVLKTLGASPIALTRTLMAPEAYLLEALASTVARHGPTEPKAMRTALVEAYARYQRISLRSAGSVFSKLPPSEVALPGAVAPASRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBV3</accession>
    <name>Q1DBV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551729.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88018">
        <property type="protein sequence ID" value="ABF88018"/>
        <property type="gene ID" value="MXAN_1618"/>
    </dbReference>
    <dbReference type="GeneID" id="41359062"/>
    <dbReference type="KEGG" id="mxa:MXAN_1618"/>
    <dbReference type="HOGENOM" id="CLU_201283_0_0_7"/>
    <dbReference type="OMA" id="KEMARAQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="60" mass="6954" checksum="BCB44B03CB679D7C" modified="2006-07-11" version="1">MQGRSTKRQKEQARKQHQQEKNAKREERKKVKSERGPRQPGEVDPDIADIIPGPQPPLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBW5</accession>
    <name>Q1DBW5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551717.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1606"/>
    <dbReference type="EnsemblBacteria" id="ABF89147">
        <property type="protein sequence ID" value="ABF89147"/>
        <property type="gene ID" value="MXAN_1606"/>
    </dbReference>
    <dbReference type="GeneID" id="41359051"/>
    <dbReference type="KEGG" id="mxa:MXAN_1606"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081285_1_0_7"/>
    <dbReference type="OMA" id="HIDEKMS"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188118" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="29886" checksum="61BFDBCD8E4C9020" modified="2006-07-11" version="1">MMNARRPLSVLLLGWTLLLPAVALAEAEPKLAPDALLRHIDEKMSFTSDYKGVIRLYETRKDGAKRAMEVHVYRREADNDLLFLSTKPRHLAGMGTLRIGRNLWDYEATTGSWRRNTQRTNLLNTFTCEADFDRSRLAEDYAGKDEGDDTVNGVAYRKLLLTAKNDQVTFPLMRIWVDPQNNIVKKVGYTASGRTLRTDIVRSYQRIKDPLSGKHVLHYKEVLETEEQEGTQMVVRYDEVVLAPLDANIFTKAWLESRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX2</accession>
    <name>Q1DBX2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551710.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1599"/>
    <dbReference type="EnsemblBacteria" id="ABF91928">
        <property type="protein sequence ID" value="ABF91928"/>
        <property type="gene ID" value="MXAN_1599"/>
    </dbReference>
    <dbReference type="GeneID" id="41359044"/>
    <dbReference type="KEGG" id="mxa:MXAN_1599"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549592_0_0_7"/>
    <dbReference type="OMA" id="ATMAYWE"/>
    <dbReference type="OrthoDB" id="530544at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="320"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="54305" checksum="92539ACB79F7037D" modified="2006-07-11" version="1">MSQPVSAPSPAFVQQLNFHARDASNEAAALQAAFALGLFGHLPETGSGEPVSLETLAKRVGGTWRGTRSVVEPLVALGFVHLEEGRGYSLRASTVAFLRDEAFTTRLKEARRWWHPLALLSQAVRGGGPVEWGGESWDVLGWYRALFLSPAPSIPSAEARDFHDRFARNPARTLALVTAAELDVLVKLVRGPVPLEVLAREVGASAEALEVLLGALAAMGIVQAQETGWGFTEAAGRALDAQSLPYFQRALPATMAYWEALGHLDEAVREQRFRLDLRDPETARRIYQENASRISSIFASHLRLSRQAATLVRSMRPLAQARVLDVGTGSGVWGAAFGLADPTTHVTYLDSPHVLDAVRPHLAKLKLEARSELWAGDCLSVDYGESRYDVILLPQIIPALPPSELPSFFARLARALRPGGLLLISGYLLTDRRDGPLDALYFALRRYVTNEGDVLSLPEFRALLGPVGLTDARGFDMPIQQVVIAHRGDVAWPDVAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC77</accession>
    <name>Q1DC77_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91020">
        <property type="protein sequence ID" value="ABF91020"/>
        <property type="gene ID" value="MXAN_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1494"/>
    <dbReference type="HOGENOM" id="CLU_3218986_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4630" checksum="A486675BF39A960C" modified="2006-07-11" version="1">MRAGIVAEHDARHAAEVPEGLRQPLQPVLLTLGLLGGASVTTQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC90</accession>
    <name>RIMO_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="1">S12 MTTase</shortName>
            <shortName evidence="1">S12 methylthiotransferase</shortName>
            <ecNumber evidence="1">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimO</name>
        <name type="ordered locus">MXAN_1476</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551592.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DC90"/>
    <dbReference type="SMR" id="Q1DC90"/>
    <dbReference type="STRING" id="246197.MXAN_1476"/>
    <dbReference type="EnsemblBacteria" id="ABF89771">
        <property type="protein sequence ID" value="ABF89771"/>
        <property type="gene ID" value="MXAN_1476"/>
    </dbReference>
    <dbReference type="GeneID" id="41358922"/>
    <dbReference type="KEGG" id="mxa:MXAN_1476"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_7"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000374899" description="Ribosomal protein S12 methylthiotransferase RimO">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="476" mass="53340" checksum="EE789B6C873F9B66" modified="2006-07-11" version="1">METTTPKSLYMMTLGCPKNRVDSEVMLGTLRHRGYTLVQEASDAQVIVVNTCAFIGPAKQESVDSILEMAELKKSGACKTLVVTGCLSQRYGEELSKEMPEVDHFLGTSAYAQIGDLLAAEASPRQVIPDPDYIHDANTPRINSMPKYTAYLKISEGCDNACAFCIIPTLRGGQRSRPIDDIVAEAKQLADSGVQELNLVAQDLTAYGHDLPGRPKLHDLLKALVQVDVKWIRLHYAYPRIFPDELIEVMASEPKIARYLDMPVQHVSDKLLLSMKRGRNSEFLKGLLTKLRERVPGLVMRTSLIVGLPGETEEDFEMLKEFVKTQRFERLGVFQYSDEEGTAAYDLPDKVPQKLIERRWREVMAIQKRINREQNKKLVGKRLEVLVEGPAPETEHLLVGRHQGQAPDIDGMVYINDGLAYPGEIVTVEVTEAHDYDLVARVVERPDPKQREHTARDAHPAPLPVAAMQRPAPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC99</accession>
    <name>Q1DC99_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pkn1</name>
        <name evidence="9" type="ORF">MXAN_1467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1467"/>
    <dbReference type="EnsemblBacteria" id="ABF86229">
        <property type="protein sequence ID" value="ABF86229"/>
        <property type="gene ID" value="MXAN_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1467"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009977_0_0_7"/>
    <dbReference type="OMA" id="QRFHAEA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="59"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="630"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="693" mass="74287" checksum="FD532EABF38A7CE6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW8</accession>
    <name>Q1DCW8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551365.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1246"/>
    <dbReference type="EnsemblBacteria" id="ABF86429">
        <property type="protein sequence ID" value="ABF86429"/>
        <property type="gene ID" value="MXAN_1246"/>
    </dbReference>
    <dbReference type="GeneID" id="41358694"/>
    <dbReference type="KEGG" id="mxa:MXAN_1246"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101758_1_0_7"/>
    <dbReference type="OMA" id="WHLDVQY"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21797" checksum="2E2190C7953491C6" modified="2006-07-11" version="1">MESEVSSATSLQALLERHVPEDVKEREDLERMRHFARSLARPFSREQLEAHFTGSAVVVDPEGARVVLLHHRKLQRWLQPGGHADVTDAGHMEATALREAREETGCRVSLHPAAPQPLDVDIHTIPARRDEPEHHHLDVRFLVVAENPDALVHDPAESFGVRWLTWDEAMTHADEVPLRRMLAKARRVVASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD17</accession>
    <name>Q1DD17_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_1197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551316.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1197"/>
    <dbReference type="EnsemblBacteria" id="ABF89934">
        <property type="protein sequence ID" value="ABF89934"/>
        <property type="gene ID" value="MXAN_1197"/>
    </dbReference>
    <dbReference type="GeneID" id="41358647"/>
    <dbReference type="KEGG" id="mxa:MXAN_1197"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_3_7"/>
    <dbReference type="OMA" id="EGMHRFT"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188498" description="Aminopeptidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="50"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="263"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="12">
        <location>
            <begin position="561"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF89934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="901" mass="98794" checksum="3A3ED4563C039019" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE8</accession>
    <name>Q1DDE8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="6" type="ORF">MXAN_1065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551185.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1065"/>
    <dbReference type="EnsemblBacteria" id="ABF89106">
        <property type="protein sequence ID" value="ABF89106"/>
        <property type="gene ID" value="MXAN_1065"/>
    </dbReference>
    <dbReference type="GeneID" id="41358517"/>
    <dbReference type="KEGG" id="mxa:MXAN_1065"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_7"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="5">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="25084" checksum="C8DFBA830E8F4286" modified="2006-07-11" version="1">MQFNITFRQFGASDSLKEYAREKVERVNRLLDRAGEAHVVLSLERHLHHADITIHSGAWVLRGRDKSDDMYASIDLAMDKIERQLRRYRDKLKSHHGRERVHHRHDLVEQLRVRHAVFELPDVDALTSLAEASASEDAPKPAVVPAQPAAPSQAAREVRATHLTVKPLTVDDAVMQMNLMNNDFYVFHNVESESLCIVYRRKDGQYGLIEPHAPAIAATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDJ9</accession>
    <name>Q1DDJ9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">MXAN_1013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551134.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1013"/>
    <dbReference type="EnsemblBacteria" id="ABF91585">
        <property type="protein sequence ID" value="ABF91585"/>
        <property type="gene ID" value="MXAN_1013"/>
    </dbReference>
    <dbReference type="GeneID" id="41358468"/>
    <dbReference type="KEGG" id="mxa:MXAN_1013"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_7"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="657"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="839"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131192" checksum="4E25503382F01EB1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDL1</accession>
    <name>Q1DDL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551122.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1001"/>
    <dbReference type="EnsemblBacteria" id="ABF90327">
        <property type="protein sequence ID" value="ABF90327"/>
        <property type="gene ID" value="MXAN_1001"/>
    </dbReference>
    <dbReference type="GeneID" id="41358456"/>
    <dbReference type="KEGG" id="mxa:MXAN_1001"/>
    <dbReference type="eggNOG" id="ENOG5030TBK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404817_0_0_7"/>
    <dbReference type="OMA" id="YEAFLCK"/>
    <dbReference type="OrthoDB" id="94457at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188516" evidence="1">
        <location>
            <begin position="24"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="674" mass="74355" checksum="1CA73EE9A95DBF45" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDU3</accession>
    <name>Q1DDU3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="3">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="3">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nbaC</name>
        <name evidence="4" type="ORF">MXAN_0919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-HAO family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551040.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0919"/>
    <dbReference type="EnsemblBacteria" id="ABF88686">
        <property type="protein sequence ID" value="ABF88686"/>
        <property type="gene ID" value="MXAN_0919"/>
    </dbReference>
    <dbReference type="GeneID" id="41358378"/>
    <dbReference type="KEGG" id="mxa:MXAN_0919"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_7"/>
    <dbReference type="OMA" id="NARKDYH"/>
    <dbReference type="OrthoDB" id="1591291at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="PTHR15497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="19959" checksum="A1BBF440A01DE9E5" modified="2006-07-11" version="1">MGRLTPINFKKWIDEHRHLLKPPVGNQQVWEDREFMVTVVGGPNARTDFHINEGEEFFYQLEGTMNLRVIDEGQVQDIPIHEGEIFLLPPNVPHSPQRPAGTVGLVLERRRQPKELDGFMWLCPQCGEKLYEEFVHVTNLVTQLPPIFEHFYGNPDNCTCKKCGTKVVKGGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX8</accession>
    <name>Q1DDX8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551005.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0884"/>
    <dbReference type="ESTHER" id="myxxd-q1ddx8">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86418">
        <property type="protein sequence ID" value="ABF86418"/>
        <property type="gene ID" value="MXAN_0884"/>
    </dbReference>
    <dbReference type="GeneID" id="41358343"/>
    <dbReference type="KEGG" id="mxa:MXAN_0884"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575963_0_0_7"/>
    <dbReference type="OMA" id="YTFPPAR"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188185" evidence="2">
        <location>
            <begin position="17"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="474" mass="51711" checksum="5EFF9149AEBF0128" modified="2006-07-11" version="1">MRRLLAAVFCAAVVLAACEDDSPPPPTPPPPSTETYPDAGTRPDAGTQEPWACQRSTTVHNAPMRLLTRLQLEMSRATSSAQRTEAIDRFVAEVEEQGGRPLVSDVKAGHPRVAFFVRGEAGRDTFVAGDFNGWSATATPLVQVRDTDLYVAEVEVPRTGPQPYKLVKDGDFIADPGARHVAWDDFNRHDVGRFNSLIYPELQDAAKGRLTAWYGVPATVLGDARDVFVYTPAEYDGPECPSLPVMYLHDGNESLTRESFAEAADSHYAARPADSAVLVFVALPDQSVRLAQYTFPPARAPGWPTPRGDDYLAFIRDDLMPRVEASYRVKTGPQETGIAGASLGGLISVYAGFQMPEKFGFVGSQSGTLFWPHDGVVDRDDGNAMIVRASQEPVVPVRFYVDHGSPVAGCTRDGEEGGDDCQSNLEFVEALRGRGYGVAHWNEPGAEHDWAFWKRRLPKLLCNFRNAAPAVCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDZ4</accession>
    <name>Q1DDZ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550989.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0868"/>
    <dbReference type="EnsemblBacteria" id="ABF91577">
        <property type="protein sequence ID" value="ABF91577"/>
        <property type="gene ID" value="MXAN_0868"/>
    </dbReference>
    <dbReference type="GeneID" id="41358327"/>
    <dbReference type="KEGG" id="mxa:MXAN_0868"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675995_0_0_7"/>
    <dbReference type="OMA" id="GRAANMY"/>
    <dbReference type="OrthoDB" id="1255164at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="377" mass="40830" checksum="03278BFE1D68C12C" modified="2006-07-11" version="1">MATRRGKLSAVSRRAQLIFMLLVSGLLHVALFVALSGSEPNDRQRRVEPRAVEMEVVYQDVTPPPEPPAPEPRQPPPDEAPPRPPSKKEDPPRHAERPRPTTTEAPDASEEPPPEVAPTGSGEPPPALAQDVPRDVPQPQQRPNLESQGLLGGGMLRGGPPSTGRTLRPGEGPDSKALAARQAEEARVRVDGWAQDAAATARASSGATHPYFAKLREGFAKQLVNPPPPDLKVLGSRMKREQVDAIARFGKTGTPIAAEPRDHRLEQRNRMQAAVEAGRAANMYMVDVTTPVLALAAIVEVWQARDGKLLDLKVLEGSGDPKFDSWAVSQLRDALASAEAPKPGGGLGIRDDGMRSRWRLEEYLGNPRVQIHLMGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE67</accession>
    <name>Q1DE67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550916.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0793"/>
    <dbReference type="EnsemblBacteria" id="ABF86158">
        <property type="protein sequence ID" value="ABF86158"/>
        <property type="gene ID" value="MXAN_0793"/>
    </dbReference>
    <dbReference type="GeneID" id="41358259"/>
    <dbReference type="KEGG" id="mxa:MXAN_0793"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535176_0_0_7"/>
    <dbReference type="OMA" id="CAAWLGC"/>
    <dbReference type="OrthoDB" id="840601at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="57944" checksum="9C5B4C28005D23B2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE68</accession>
    <name>Q1DE68_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550915.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0792"/>
    <dbReference type="EnsemblBacteria" id="ABF87146">
        <property type="protein sequence ID" value="ABF87146"/>
        <property type="gene ID" value="MXAN_0792"/>
    </dbReference>
    <dbReference type="GeneID" id="41358258"/>
    <dbReference type="KEGG" id="mxa:MXAN_0792"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_7"/>
    <dbReference type="OMA" id="WAFPAPE"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188645" evidence="2">
        <location>
            <begin position="24"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="69"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="212"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="486" mass="51138" checksum="46C01F26926E87BB" modified="2006-07-11" version="1">MSAPLSWKAAFTTLLLSSVPAAAQGSAAAPKPATAAPAQQGVTLPKATTVTLKNGAKLQLVERKELPLVSFSAWVRGGALGDPAGKEGLAALTGELLQKGAGGRDARQFAEAVDGVGGELQVAANLEALVISGQFMSRDTGLMVELLTDMLTRPRFDAKELEKVRARKASEIAAAKDGDPRMLIGAYFQAFHFAGHPYGTPVNGSEASLPGLSREDVLAYAKNHLGADRLVLSVVGDFDAKALAKKLESSLGGWARAATPAPTVPATAASKGRRVLLVDKPDATQTYFWIGNTGISRDDPDRASVRVAETVFGGRFTSLLNTELRVKSGLSYGANSVFIRHTRPGPVIIASYTKTESTGRAIDLALETLAGYRKSGMDDAMLASAKSYVLGQFPPTLETGTQVAGKLSELAFYGLDASDVDGFASAVSATTREGVHGIIQRKLPAPEDLTFVLIGKASDIREAARKYGTVTEMKISDKHFAPPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE85</accession>
    <name>Q1DE85_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550898.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0772"/>
    <dbReference type="EnsemblBacteria" id="ABF87744">
        <property type="protein sequence ID" value="ABF87744"/>
        <property type="gene ID" value="MXAN_0772"/>
    </dbReference>
    <dbReference type="GeneID" id="41358241"/>
    <dbReference type="KEGG" id="mxa:MXAN_0772"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="TMATHVA"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="352" mass="37129" checksum="58A6788FF3DC9F67" modified="2006-07-11" version="1">MPLLSLDDVTLRYSSSGTAAVDRLSLAVEPGEVLALLGPSGCGKTTTLRLVAGFERPNSGTVTLDGRTLASPGAFVPSEQRSVGMVFQDYALFPHLSVVENVAFGLTAMPRQEARARASNMLKLFGLEGFESRMPHALSGGQQQRVALARALAPGPRVLLLDEPFSSLDSALRASTRMEVRRVLKSLGATVMLVTHDQQEAMAFADRLAVMRAGQVEQVGTPEAVYATPRTAFVAYFLGGTNLLPGVGFGNGARTLLGILPVTGAPAKGNVLLSLRPEAMRLVPDTDGVALGGALRAEVLAREFQGPSAEFTVACNGLELTVRGAPDLPLRAGDRARLEVVGRAMVLEDIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEG9</accession>
    <name>Q1DEG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferric siderophore ABC transporter permease protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ferric siderophore ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0686</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK 1622</strain>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DK 1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550816.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0686"/>
    <dbReference type="EnsemblBacteria" id="ABF87822">
        <property type="protein sequence ID" value="ABF87822"/>
        <property type="gene ID" value="MXAN_0686"/>
    </dbReference>
    <dbReference type="GeneID" id="41358161"/>
    <dbReference type="KEGG" id="mxa:MXAN_0686"/>
    <dbReference type="eggNOG" id="COG4606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_3_0_7"/>
    <dbReference type="OMA" id="WFAGSFT"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLH55575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="33773" checksum="E4244A02A16087DA" modified="2006-07-11" version="1">MKRAFAAAAVLVTLAVVSLLIGASDVSWRALFAPEPDERALQVLVISRLPRLFAVMLAGTSLGVAGLIMQMIARNRFVEPTTAGTAESASLGLLTATLLAPGLPVLGKMMVATVFALAGTALFLLVLRRIPLRSALIVPVVGLILGGIIDSATTFFAYRYDLLQTVNAWTTGDFSTVLRGRYELLWVTLGLTCAAYTAADRFTVAGMGETFTTNLGLNYPRIVALGLVIVALVTAMVVVTVGMIPFLGLIVPNLVSMVMGDNARRSIPWVAVSGAAFVLLCDIVGRVVRHPYEIPGGTIAGVIGSVLFLYLLLKRGARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL3</accession>
    <name>Q1DEL3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0642"/>
    <dbReference type="EnsemblBacteria" id="ABF87145">
        <property type="protein sequence ID" value="ABF87145"/>
        <property type="gene ID" value="MXAN_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0642"/>
    <dbReference type="HOGENOM" id="CLU_2369908_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="95" mass="10763" checksum="5EE3869F7D61D387" modified="2006-07-11" version="1">MWVSSIGQEAGGSAWIRTLPALAWRLLYRKAEDAPRGRMTMTTDTPAWTRDNEGWLVRVKVGGRIQEVRCTTESQARYFATVLAMNPPKPSKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL9</accession>
    <name>Q1DEL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550767.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0636"/>
    <dbReference type="EnsemblBacteria" id="ABF89666">
        <property type="protein sequence ID" value="ABF89666"/>
        <property type="gene ID" value="MXAN_0636"/>
    </dbReference>
    <dbReference type="GeneID" id="41358114"/>
    <dbReference type="KEGG" id="mxa:MXAN_0636"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032789_0_0_7"/>
    <dbReference type="OMA" id="AFDANVP"/>
    <dbReference type="OrthoDB" id="1223599at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="404" mass="43887" checksum="620F699D6441B40D" modified="2006-07-11" version="1">MKKAFEQNVSRAKPRLRLGALTGLVDPVEPTPPEPEAEATPEPVAEAPDLSAEVRARIERARTPRPSAAQAMDAALREPDDAPVYEEPPPEPEAVADVPVTYGAPPEAEALLDTEPHAGPVTFAAPPPALHFDAVSPPPEAHPMTQASAPVSMPHVTATVAEPVARVEAPPTEVEVQRPAPPREDGQDSSARRERLKARLKAVRENPRPEPLPATVAEAGQRAVERITHLQAELVKVKALNLSLTQDLEVSRRQAEKATEEARLRMDEARRLSSEMEGRVKLLADLERELSALEGERDEALLSLQETRQALQAAAKEREALEEEVARGKQSLVDSLAEEERLAGELESAKDESTSLHRAVEALQGERDVLAQQVASLTAERAELLEARKALESVHRALSQATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFF6</accession>
    <name>Q1DFF6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550481.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0343"/>
    <dbReference type="EnsemblBacteria" id="ABF86968">
        <property type="protein sequence ID" value="ABF86968"/>
        <property type="gene ID" value="MXAN_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="41357841"/>
    <dbReference type="KEGG" id="mxa:MXAN_0343"/>
    <dbReference type="eggNOG" id="ENOG5030BHA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112879_0_0_7"/>
    <dbReference type="OMA" id="PAYHEGI"/>
    <dbReference type="OrthoDB" id="1255131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="198" mass="21226" checksum="AD6AAD7EB55FA1AC" modified="2006-07-11" version="1">MRRRTMPSNKAELEARLAAVHPGDSVRGLFFKSVLSLVQQQAGLAALETVRQGALGAAYTDLLTYPARDFLTLLYRAADALEPLLGPEDAVFHACGEKDVTRFSTGPGMLIFGIISRGDPQKLFAGAQMGYGAAVSYGSRDYVPTGPTSGTLHMRRDMLPPAYHEGILTGALKVLGLQGTARATPRGIDSADYDIQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK4</accession>
    <name>Q1DFK4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550433.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0289"/>
    <dbReference type="EnsemblBacteria" id="ABF91045">
        <property type="protein sequence ID" value="ABF91045"/>
        <property type="gene ID" value="MXAN_0289"/>
    </dbReference>
    <dbReference type="GeneID" id="41357788"/>
    <dbReference type="KEGG" id="mxa:MXAN_0289"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014657_1_1_7"/>
    <dbReference type="OMA" id="FNQIYGP"/>
    <dbReference type="OrthoDB" id="1055204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02953">
        <property type="entry name" value="DsbDgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035671">
        <property type="entry name" value="DsbD_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="5">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="774" mass="79379" checksum="88FD045EC08473C4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT0</accession>
    <name>Q1DFT0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550357.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0211"/>
    <dbReference type="EnsemblBacteria" id="ABF92986">
        <property type="protein sequence ID" value="ABF92986"/>
        <property type="gene ID" value="MXAN_0211"/>
    </dbReference>
    <dbReference type="GeneID" id="41357713"/>
    <dbReference type="KEGG" id="mxa:MXAN_0211"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="QGIRVCT"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="248" mass="26263" checksum="9627CAAE79EBC92F" modified="2006-07-11" version="1">MQLKDLKIIVTGGAQGMGAHFAQRLHEAGAQVAVGDVAEERLAALPAGIHRRKLDVSSEEDIVSFVNWAQGAMGGLNGLINNAGILRDALLVKKDRTTGEVKKLSTADWNAVIGVNLTGATLMVREVVAKVAESGQKGGVVVNMSSIARHGNRGQSNYVSAKAALAANTVTWSREFSPFGVRVGAVAPGMIETPMTQGMNQKARDALVSNIPVGRIGVPEDIWLAVKFILECDYFNGRTIDVDGGLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFV5</accession>
    <name>Q1DFV5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550332.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0185"/>
    <dbReference type="EnsemblBacteria" id="ABF90673">
        <property type="protein sequence ID" value="ABF90673"/>
        <property type="gene ID" value="MXAN_0185"/>
    </dbReference>
    <dbReference type="GeneID" id="41357688"/>
    <dbReference type="KEGG" id="mxa:MXAN_0185"/>
    <dbReference type="eggNOG" id="COG4946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043792_0_0_7"/>
    <dbReference type="OMA" id="CGIEAPY"/>
    <dbReference type="OrthoDB" id="697026at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030916">
        <property type="entry name" value="ELWxxDGT_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04534">
        <property type="entry name" value="ELWxxDGT_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="ABF90673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="540" mass="57864" checksum="94641060823BE3AF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG74</accession>
    <name>Q1DG74_MYXXD</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87454">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_173997_0_0_7"/>
    <dbReference type="OrthoDB" id="1857259at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="110" mass="11932" checksum="8D12EAF4E92BDB02" modified="2006-07-11" version="1">MGFLGGIFLAVALQAGPVEKEQAQTPVEVAAPVFNPSACAKKRVDPCGCHHVYGIRHCHPNRKGDHCEAPVKAEVEAPRKSRDASKKADTQARTREPEKMQLDPSKSVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVP8</accession>
    <name>Q1CVP8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7419"/>
    <dbReference type="EnsemblBacteria" id="ABF90421">
        <property type="protein sequence ID" value="ABF90421"/>
        <property type="gene ID" value="MXAN_7419"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7419"/>
    <dbReference type="HOGENOM" id="CLU_210986_0_0_7"/>
    <dbReference type="OMA" id="ARDPHPM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187953" evidence="2">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="58" mass="6454" checksum="EA1E2C5FB07B6DB0" modified="2006-07-11" version="1">MAKLILMSVLILTIALPAKAARDPHPMRGLKKAILWFVLFNAAYTYGVLVWVPRLGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVQ2</accession>
    <name>Q1CVQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bacterial sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_7415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557326.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7415"/>
    <dbReference type="TCDB" id="9.B.18.1.6">
        <property type="family name" value="the xanthan glycosyl transferase, gumd (gumd) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90739">
        <property type="protein sequence ID" value="ABF90739"/>
        <property type="gene ID" value="MXAN_7415"/>
    </dbReference>
    <dbReference type="GeneID" id="41364571"/>
    <dbReference type="KEGG" id="mxa:MXAN_7415"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_7"/>
    <dbReference type="OMA" id="RPGLTCI"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="301"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="494" mass="53925" checksum="0548E65ED1BCA0BA" modified="2006-07-11" version="1">MDTMSGATASAAVVGAPGSANAQGQVIEEVQGPPKLAPGSAAKLNLTVDLVLLSSVLVGSAWLSGQLSAESGWKVSGLVLAAWVVWIVTGTALCLYDSRFAERSKLDHVALVSVTTLAVVTVLTLGSVAVPTVVTSPVVGPLLFIFWPVTLLLRLFVFRPVASQERPMDAVLIVGTGAMGRYTGEDLANRGRRQILGYVRFHDDNGSVGELPGPVMGSVDDLEHILRNTAVDEVYIAGNTLKQGESMQAAIKLAERFGVPFALPAHSFRLDRARPVERRAVADGFLHFAAVSPKPHQMAMKRLFDICVSAAALWALLPLLGMVALAVKFTSKGPIFFKQLRVGQNGKPFYMLKFRSMVVNAEELKEKLAALNEQTGPVFKMKHDPRITGIGRFIRKFSIDELPQFINVLRGEMSIVGPRPPVPTEVAKYETWQRRRLSVRPGLTCIWQVSGRNQISFEEWMYLDMQYIDHWSLTSDLRLLLQTVPVVLTGRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW1</accession>
    <name>Q1CVW1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557267.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87973">
        <property type="protein sequence ID" value="ABF87973"/>
        <property type="gene ID" value="MXAN_7354"/>
    </dbReference>
    <dbReference type="GeneID" id="41364515"/>
    <dbReference type="KEGG" id="mxa:MXAN_7354"/>
    <dbReference type="HOGENOM" id="CLU_1382821_0_0_7"/>
    <dbReference type="OMA" id="RWHDKER"/>
    <dbReference type="OrthoDB" id="1779499at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="18523" checksum="2CBED8023C4BA8ED" modified="2006-07-11" version="1">MSEQGYPVTVAVRRPDGRVEQVRVGTAFKSGEGFTLTLGEMSIGGTPDAAAPAARRSAPASSGGGGGGDGMVFPNYGRSKGGPIVGASMGDLEFYANGARRTLNDASKSRWHDKERQLLAAIEAEIARQRGGDEGGGSDGGYGSQGGYGNQGGYGGSRGGGGFGGGSYGGDDIPPPNDDDNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW85</accession>
    <name>Q1CW85_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557144.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7225"/>
    <dbReference type="EnsemblBacteria" id="ABF87601">
        <property type="protein sequence ID" value="ABF87601"/>
        <property type="gene ID" value="MXAN_7225"/>
    </dbReference>
    <dbReference type="GeneID" id="41364394"/>
    <dbReference type="KEGG" id="mxa:MXAN_7225"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="PLECYHE"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="337" mass="36460" checksum="3D5EA57E34067BED" modified="2006-07-11" version="1">MATVSLEDVRKVYRGGVAAVKGVSLDIADGEFISLVGPSGCGKSTTLNLIAGLEEMSGGTLRIDGAVVNDMSPRERDIAMVFQSYALYPHLDVARNLAFPLKVAGVAKADIDARVREVASLLGLEGLLSRKPKELSGGQRQRVALGRALVRRPKVFLFDEPLSNLDAALRTQMRGEIKKLHEQLKATFVYVTHDQAEAMTLSDRVVVMNQGEVQQVAPPRELYDAPANLFVAGFFGAPRINLVKPRTLGLPDADVVLGLRPEHLEVGQGTPPPEALEGHVYLVESMGAESWVTVDVAGERMVARAAGDFRVPTGAPVWLRYDAAKLRRFDAKSGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW99</accession>
    <name>Q1CW99_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557130.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92324">
        <property type="protein sequence ID" value="ABF92324"/>
        <property type="gene ID" value="MXAN_7211"/>
    </dbReference>
    <dbReference type="GeneID" id="41364381"/>
    <dbReference type="KEGG" id="mxa:MXAN_7211"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1729418_0_0_7"/>
    <dbReference type="OMA" id="CERHRGT"/>
    <dbReference type="OrthoDB" id="1456205at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="17114" checksum="B51609FF866DD5B8" modified="2006-07-11" version="1">MSIQKQERTPSWTGLGVGTDRKSFLDAISSQIPDYEADKAAEAVFCALSERLSGSWVAHLREQLSPDVRELLRGCHRHRGEAPAKLDRDDFYLMVANHLNAEPENVRLVLHGVFSALHAQITEGEAKKLEQQLPAWLQGTWAAARMHVDRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG3</accession>
    <name>Q1CWG3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557066.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7147"/>
    <dbReference type="EnsemblBacteria" id="ABF92255">
        <property type="protein sequence ID" value="ABF92255"/>
        <property type="gene ID" value="MXAN_7147"/>
    </dbReference>
    <dbReference type="GeneID" id="41364321"/>
    <dbReference type="KEGG" id="mxa:MXAN_7147"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_16_2_7"/>
    <dbReference type="OMA" id="SVWLDTV"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="414" mass="45057" checksum="984AD218193B503D" modified="2006-07-11" version="1">MDIPKAKKPRRKPWVLAIGGACVLLLVTVGLSRLRPAAPTVERASVWLDTVKRGPMVRQVKGAGTLVPEYIRWLTADTAGRVERIHVRPGATVTADTLLLELSNPDVQLQALEAERQLASVEADLIQVRMELETQRLAQEAMVAALINESAEAGRRSDANEALHQKAHIGDLEMQQAREKAAELSRRLELERKKLQVVASSMKEQLTAQQGQVERLKAVARFRRAQVESMKVLAGEDGVLQDLPLELGQWVTPGVLLAKVVKPERLKAELRIAETQARDIQPGLKALVDTRNGVVEGQVARVAPAASQGTVRVEVSLPAELPRGARPDLTVEGTVELERLGDVLSVGRPAGAQPNATMALFRLMPGSDEAVRVPVQLGRGSVNAVEVLQGLQEGDQVVLSDMAAWDAVERVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC0</accession>
    <name>Q1CXC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556761.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6836"/>
    <dbReference type="EnsemblBacteria" id="ABF90755">
        <property type="protein sequence ID" value="ABF90755"/>
        <property type="gene ID" value="MXAN_6836"/>
    </dbReference>
    <dbReference type="GeneID" id="41364025"/>
    <dbReference type="KEGG" id="mxa:MXAN_6836"/>
    <dbReference type="eggNOG" id="ENOG5032JVP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224141_0_0_7"/>
    <dbReference type="OMA" id="WHAQVEA"/>
    <dbReference type="OrthoDB" id="1701980at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="27249" checksum="C83555CF90E7E4CF" modified="2006-07-11" version="1">MHVIHDVTLSRAFLEWGPGWDGRALSCREGGRVIVSRLIWSMGFAGLALACAVANWLHRPVELPYQAAEPEASTPLAQAPTPRPRSVAPGPSTPVAPAQPDARPITRPTSASEAERSARSRRTPPAQRLRLVTALRGTHPSPEARRDAVLAELTASGESHEPWTAQARAALAKWHAQVEADVLPVQAEPPRCFAAGCVARVTFPDSDSFQESFRRTADLRLGEGTTHMQLPPERRASGEVVAAWLVLRPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM8</accession>
    <name>Q1CXM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556653.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6728"/>
    <dbReference type="EnsemblBacteria" id="ABF88951">
        <property type="protein sequence ID" value="ABF88951"/>
        <property type="gene ID" value="MXAN_6728"/>
    </dbReference>
    <dbReference type="GeneID" id="41363921"/>
    <dbReference type="KEGG" id="mxa:MXAN_6728"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_7"/>
    <dbReference type="OMA" id="VDWRIRE"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="31403" checksum="B82F4CC021C539A2" modified="2006-07-11" version="1">MKAVVLKSYGDVDALAVQDMPEPKVGPGEVKVRVTAAGINPVDWKIRRGDMKAMMPLQFPTILGRDVAGEVMEVGPGVSDFKPGDRVMGVVNAGYAEKVVAPVESWAKVPESMDLKDAAALPLVTLTGVQLMEEAVNPKKGDTVLVIGALGAVGRAAVFAAKARGAKVLAGVRGSQKAEAQKLGVDGVFALDVADEFSKLPMLDAVADTVGGQVVARVLEKVKPGGTLGSVLGEPPEAKGRQITVRAILSHPDSRRLTQLGQAVAKGDLVIPVSKRFPLEQVKEAQKLAEQGGVGKVLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXN2</accession>
    <name>Q1CXN2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556649.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6724"/>
    <dbReference type="EnsemblBacteria" id="ABF86607">
        <property type="protein sequence ID" value="ABF86607"/>
        <property type="gene ID" value="MXAN_6724"/>
    </dbReference>
    <dbReference type="GeneID" id="41363917"/>
    <dbReference type="KEGG" id="mxa:MXAN_6724"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_5_1_7"/>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="32171" checksum="E8AC1768B79EBFE9" modified="2006-07-11" version="1">MLVVNTRSRSGREAFETARETLVARGVSIVECHALSRADRLDAVVERMVARGTRRLIVGGGDGTLSRAVVRLLGRDVTLGVLPLGTGNDFARSLGIPPDIEAACDVIAQGYTARVDVGLANGRPFLNAASLGLATGIAKRLTKRLKQRAGKLAYPVAAAAEMKDLRPFHIRLKADDQELALDVLQLVVGNGLYHGAGNMVAPDARLDDRRLDIYAIAAPSAASGHEGTGLGQLQDIATLMRVALSLRSGEHVEHPAVTALRAARLYVEAAPVQEVNADGELVGKTPMRFEVAPAALRVYAPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXU1</accession>
    <name>Q1CXU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative branched chain amino acid ABC transporter, periplasmic amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556590.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6665"/>
    <dbReference type="EnsemblBacteria" id="ABF89059">
        <property type="protein sequence ID" value="ABF89059"/>
        <property type="gene ID" value="MXAN_6665"/>
    </dbReference>
    <dbReference type="GeneID" id="41363863"/>
    <dbReference type="KEGG" id="mxa:MXAN_6665"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_7"/>
    <dbReference type="OMA" id="DGWDSEK"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188020" evidence="4">
        <location>
            <begin position="19"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="5">
        <location>
            <begin position="52"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="42109" checksum="B3E5CE8D1F079232" modified="2006-07-11" version="1">MRRLAPMLLAALAVMVAACEKKTQPAPSGEGGTQAAQGQGAAPGGAPVDANTILLGQVGSLTGGQATFGISTRNGIELALKEANAAGGVKGKKLSIRVYDNQSKPEEAAQAATRLITQDKVALILGDVASSNSLAMAEKAQAAGVPMITPSSTNPTVTDKGDYIFRVCFIDPFQGFVMAKFARENLKLNTVAVLQDNKSAYSIGLADVFTRKFTEMGGKVTAVESYSQGDTDYRAQLTAIRKSQPEGIYVPGYYSEVGIIARQAREVGLKVPLMGGDGWDSEKLFELGGSAIEGSYFSNHYSPDNPDPRVQKFIADYKAAYGAVPDALAALGYDSARVAVDALERAKDLSGPSVRDAIAQTKDFPGVAGTVTLDAQRNAVKSAVVLKVEDGKTQYVTTINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXV6</accession>
    <name>Q1CXV6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556575.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6650"/>
    <dbReference type="EnsemblBacteria" id="ABF91980">
        <property type="protein sequence ID" value="ABF91980"/>
        <property type="gene ID" value="MXAN_6650"/>
    </dbReference>
    <dbReference type="GeneID" id="41363846"/>
    <dbReference type="KEGG" id="mxa:MXAN_6650"/>
    <dbReference type="eggNOG" id="ENOG5030IDZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473697_0_0_7"/>
    <dbReference type="OMA" id="WKGYFTE"/>
    <dbReference type="OrthoDB" id="1412753at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="20798" checksum="879C9F4B415B0B18" modified="2006-07-11" version="1">MEVKGVAFLARQQLMVQTHGEAAWKAFLTDFAKKEPFFSKPVMPVSRMPADAFLRLNDELLARFYNNNPSAYWQFGVKSAEYALGQGQLKAMFSQGDFRRFLLFTPGIWKGYFTEGDLNVLPGQDHTDLHITHVPRPHPYFELSVMGFASGGLAYLGAQNLKHQVLKGFTRNDNEVLYRFNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW7</accession>
    <name>Q1CXW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chalcone/stilbene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556564.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6639"/>
    <dbReference type="EnsemblBacteria" id="ABF87000">
        <property type="protein sequence ID" value="ABF87000"/>
        <property type="gene ID" value="MXAN_6639"/>
    </dbReference>
    <dbReference type="GeneID" id="41363836"/>
    <dbReference type="KEGG" id="mxa:MXAN_6639"/>
    <dbReference type="eggNOG" id="COG3424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_0_1_7"/>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="4">
        <location>
            <begin position="222"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="360" mass="38986" checksum="F8E99DF3327BC157" modified="2006-07-11" version="1">MLSASGQDRSPSIRAVGRALPPHYASQEELIAAFRELWATRHFNLERLEDLHRAVQVGGRHLALPLEAYPPLLTFQQRNDAWIRSATELGETVVRKALDAAELTPGEVDHVFFVTVTGIATPSIDARLANRMRFREDFKRTPLFGLGCVAGAAGVARAADYLRGFPEHTAVVIAVELCSLTLQREDLSIPNIIASGLFGDGAACAVLRGAAAPGARGPRVVASRSVFYPDTERIMGWDVVDTGFKVVLSAKVPGLVKDHIRGNVDGFLAQHGLKRGDIRHWVAHTGGPKVLEAFEEALELAPSALERSWASLREVGNLSSASVLFVLGETLESVRAQPGEWGVMMAMGPGFGAEMVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX9</accession>
    <name>Q1CXX9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6626"/>
    <dbReference type="EnsemblBacteria" id="ABF86435">
        <property type="protein sequence ID" value="ABF86435"/>
        <property type="gene ID" value="MXAN_6626"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6626"/>
    <dbReference type="eggNOG" id="COG2215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304251_0_0_7"/>
    <dbReference type="OMA" id="HCAAMAT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="25392" checksum="8C196B38F1EDB447" modified="2006-07-11" version="1">MTADSRRVIILMKGRFSSPAGLPIEARLGCRVVQPILLAFLLGLSQGMLHAVGPDHCAAMATLGTLGGGRRRAAIATAVRFALGHAVMLGGIAALCILAGVGLSETFERWAEIFGGAVLVALAVAALLFPSSLDHGHPHLPGHTQEPHQHVHTVSTTAGALMAVSGVRSLLLALPPLLVGGSMSAAAWMYLPGFALGILIGMGVVGLIFAEGIARLNAQITRWVQRVVAVGSGALGLFWIGSRLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY9</accession>
    <name>Q1CXY9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556542.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6616"/>
    <dbReference type="EnsemblBacteria" id="ABF89032">
        <property type="protein sequence ID" value="ABF89032"/>
        <property type="gene ID" value="MXAN_6616"/>
    </dbReference>
    <dbReference type="GeneID" id="41363814"/>
    <dbReference type="KEGG" id="mxa:MXAN_6616"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052008_1_0_7"/>
    <dbReference type="OMA" id="AVFHGRI"/>
    <dbReference type="OrthoDB" id="546910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021147">
        <property type="entry name" value="DUF697"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05128">
        <property type="entry name" value="DUF697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="38574" checksum="DBE2959350A2AB84" modified="2006-07-11" version="1">MDIHLAEEIRKQVEEAFRKRGRVNIVIAGRSGVGKSTLVNAVFHGRIADTGQGRPVTKETREYTKDDIPVSILDTRGLELGAFQETLKLLEELVAARAKDADATRHLHCAWLCISEDSRRVEDGDVKAVEMLARHMPVVVVVTKARSDQGFRAEVQKLLPMARNVMRVRALQETDDEGHTLQPKGLVELVELTMELVPEAQRNAFAAAQRVSISQKRKRAHGIVASAAAAAGLIGAVPIPFADAALLVPTQVGMLAGVSSVFGLPLTEAFLSTLVGAGITGLGATFTGQSIVSGLLKLVPGPGTVIGALISATTATALTTLFGEAYVAVLSKLMEKRCGELPTEEEVIQAFREEMSLRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYB2</accession>
    <name>Q1CYB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556419.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6489"/>
    <dbReference type="EnsemblBacteria" id="ABF86101">
        <property type="protein sequence ID" value="ABF86101"/>
        <property type="gene ID" value="MXAN_6489"/>
    </dbReference>
    <dbReference type="GeneID" id="41363696"/>
    <dbReference type="KEGG" id="mxa:MXAN_6489"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794166_0_0_7"/>
    <dbReference type="OMA" id="YSHKGMR"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="11"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="39581" checksum="C378B447D1A28EE9" modified="2006-07-11" version="1">MEPTPKVIRHFHPVLSARALGTRPVRVEVAGRAYALFRDGTGQPAALADACPHRFAPLSKGTVRADGRLQCPYHGWRFDAEGRGSNPSQPELRHCDARSFQVVERYGYLWLAERDTPLSAMPDMGDEGYVFGGAFSTHFAAPLHVSLDNFSEDEHTPYVHTRLGWDDPNAGRVEFEARNLEDRTEVHYRAPQRPAPIMTVLGVRDGDFFQNDWVTRFDPVRSQYTIRWVAPDGSPRPFITRANIFFVPETARTTRLHVFSFLRTEQRLLRPLLPVAARAAMALTWWEVRDDARFITTVADTPYSHKGMRLDRFDAPLVHQRRLMERIYYGAGPKMTGAVVPLSREAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYS2</accession>
    <name>Q1CYS2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556259.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6326"/>
    <dbReference type="EnsemblBacteria" id="ABF86490">
        <property type="protein sequence ID" value="ABF86490"/>
        <property type="gene ID" value="MXAN_6326"/>
    </dbReference>
    <dbReference type="GeneID" id="41363542"/>
    <dbReference type="KEGG" id="mxa:MXAN_6326"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_5_1_7"/>
    <dbReference type="OMA" id="GMLIQIE"/>
    <dbReference type="OrthoDB" id="1069752at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20076" checksum="B9C2703A9D60FF9B" modified="2006-07-11" version="1">MNDDDLPGRLARNIRSLRETRGATQAQLSRLAGVPRATWAHLESGAANPTLSVLHRVAAALQVSLEELIAKPRASARHYPRATLPVRTRGGGMLRKLLPDPLPGMEFDRVELPPQVRITGVPHTPGTREYLACESGELVLVASGERFHLQPGDVVVFRGDQKHSYENPGARTAVGYSVVLLAPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYX5</accession>
    <name>Q1CYX5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase HEAT-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556209.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6269"/>
    <dbReference type="EnsemblBacteria" id="ABF90197">
        <property type="protein sequence ID" value="ABF90197"/>
        <property type="gene ID" value="MXAN_6269"/>
    </dbReference>
    <dbReference type="GeneID" id="41363491"/>
    <dbReference type="KEGG" id="mxa:MXAN_6269"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453304_0_0_7"/>
    <dbReference type="OrthoDB" id="1534002at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="579" mass="61459" checksum="073BECD60A775B52" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZK6</accession>
    <name>Q1CZK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative response regulator/chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555981.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6032"/>
    <dbReference type="EnsemblBacteria" id="ABF86894">
        <property type="protein sequence ID" value="ABF86894"/>
        <property type="gene ID" value="MXAN_6032"/>
    </dbReference>
    <dbReference type="GeneID" id="41363270"/>
    <dbReference type="KEGG" id="mxa:MXAN_6032"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965856_0_0_7"/>
    <dbReference type="OMA" id="YTIHTAS"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="3">
        <location>
            <begin position="129"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="288" mass="31114" checksum="C4231858FE944210" modified="2006-07-11" version="1">MSLPSLLLVDDSDAILALERAILSGHYTIHTASNGREALEKVGRLRPAAVLLDLSMPEMDGDEVLQRMKADPATADIPVIIISSEKSRAEACLGLGAETFLAKPFRADELLQTVGEAMTSAWQRARTGSLLVLRVTVGELEFAIPLDAVREVLLHPATRPLPTGPAYLREYVEVRGAALCVLDVARRLGVEHKLTRVERMLVVIEAEGVSLALAVDTVKDPEEYAAADIDRRERVGGADHGPLREGLIGMLRSGGRSLPILDPRVFIARGLLRELPAMLEAAEAGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZL9</accession>
    <name>Q1CZL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal large subunit pseudouridine synthase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rluA</name>
        <name evidence="4" type="ORF">MXAN_6019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555968.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6019"/>
    <dbReference type="EnsemblBacteria" id="ABF87152">
        <property type="protein sequence ID" value="ABF87152"/>
        <property type="gene ID" value="MXAN_6019"/>
    </dbReference>
    <dbReference type="GeneID" id="41363257"/>
    <dbReference type="KEGG" id="mxa:MXAN_6019"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037416_0_0_7"/>
    <dbReference type="OMA" id="MAEFWWG"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="3">
        <location>
            <begin position="363"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="559" mass="61957" checksum="B72EF2F06F2F5EAE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZM1</accession>
    <name>Q1CZM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555966.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6017"/>
    <dbReference type="EnsemblBacteria" id="ABF88789">
        <property type="protein sequence ID" value="ABF88789"/>
        <property type="gene ID" value="MXAN_6017"/>
    </dbReference>
    <dbReference type="GeneID" id="41363255"/>
    <dbReference type="KEGG" id="mxa:MXAN_6017"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_5_7"/>
    <dbReference type="OMA" id="FICNHLS"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="27334" checksum="9CA80634D0FE2A0E" modified="2006-07-11" version="1">MLRILFFLMSKLPEGARQQMVRALMNGVWDTLANEKVLGRENIPDQPCLFLCNHLSNADGFTLDRAFRPRKVVFLAGVKLKSTVMTRLASETMETIAIKPNSPDIEAMRRALDTLKAGKSVLIFPEGARSRTGTLTQAKKGLSLIAKRAGVPVVPVALQGTEKLMPINDSDMGGERLFKADVFVRFGPPFRVEALEAEVAGAEDPRQALVDAMMRRVAELLPPEYRGFYADTSAPAAPAPDLERPSAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZX2</accession>
    <name>Q1CZX2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555865.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5914"/>
    <dbReference type="EnsemblBacteria" id="ABF90611">
        <property type="protein sequence ID" value="ABF90611"/>
        <property type="gene ID" value="MXAN_5914"/>
    </dbReference>
    <dbReference type="GeneID" id="41363152"/>
    <dbReference type="KEGG" id="mxa:MXAN_5914"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115757_0_0_7"/>
    <dbReference type="OMA" id="PEWLGAN"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="21782" checksum="F3E295AF5D0FB7E7" modified="2006-07-11" version="1">MARKTPQWEGRIVRVLVCTERKSFVTKELPEARVSFEGLEGDRHAGLTRAADVRTPWFPKGTPIRNTRQFSLVSSEELAQVAETLGIPRVLASWLGANLEVAGVPRLTHLPPGTRLFFPEDTTLVVEGENEPCIGPGRVIEAHHPDVQKLASRFVKAAWQRRGLVAWVERPGIIRAGDTVKVVLPRPVTYVLPSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D055</accession>
    <name>Q1D055_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgP</name>
        <name evidence="12" type="ORF">MXAN_5831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555782.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5831"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91196">
        <property type="protein sequence ID" value="ABF91196"/>
        <property type="gene ID" value="MXAN_5831"/>
    </dbReference>
    <dbReference type="GeneID" id="41363071"/>
    <dbReference type="KEGG" id="mxa:MXAN_5831"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_7"/>
    <dbReference type="OMA" id="KHKRTFT"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="834" mass="94772" checksum="AC437B013979EEA8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D089</accession>
    <name>Q1D089_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase HEAT repeat-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555748.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5797"/>
    <dbReference type="EnsemblBacteria" id="ABF90049">
        <property type="protein sequence ID" value="ABF90049"/>
        <property type="gene ID" value="MXAN_5797"/>
    </dbReference>
    <dbReference type="GeneID" id="41363040"/>
    <dbReference type="KEGG" id="mxa:MXAN_5797"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1142055_0_0_7"/>
    <dbReference type="OMA" id="RPPRFYV"/>
    <dbReference type="OrthoDB" id="1435274at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188090" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="26310" checksum="17A2D45FB8E17AA1" modified="2006-07-11" version="1">MQLLSSALVLLLLAPCAALAQGDSRIAFLGKQLQKSKDPRSRSQAALVLGATEDPEAVPLLCNGLKDESELVRAAAAKGLAKLLEPGGLDCLQAHKADADASVQAAVSDAVGALKEYQSRPPRFYVHLEAVKDRTGKLPADLVKATEARLRSRLMRSGAQLAPAKETKAAAKGTLKKLRVRGYRITPELHATDGGGLRVALVCLTYPDLSLMGQVEVNAAGAQPGDLLKALVPRAVEEAAETFEWSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C6</accession>
    <name>Q1D0C6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555711.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5760"/>
    <dbReference type="TCDB" id="2.A.1.49.7">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91689">
        <property type="protein sequence ID" value="ABF91689"/>
        <property type="gene ID" value="MXAN_5760"/>
    </dbReference>
    <dbReference type="GeneID" id="41363003"/>
    <dbReference type="KEGG" id="mxa:MXAN_5760"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_7"/>
    <dbReference type="OMA" id="DQMVMSP"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="422" mass="43738" checksum="50506112F83F2394" modified="2006-07-11" version="1">MNAQSAASPAASAVPASNAGYALLILTLINLVNYLDRYIVAVALPDIQKEFGINDTQSGLLGTMFIVVFMLASPLGGFLGDRYPRRLLVVGGVVLWSLATGASGLATSFGALLLARAVIGIGEAGYGAVAPSIISDLYPRTQRTRMLAFFYIAIPVGAAAGYGLGGWLTQAYSWHVAFFAGGVPGLILGAMAFFMPEPQRGAMDGPDAQAKLPFMVGLKGLARNSAFWAVTAGYTLMTFSIGGLGFWMPTYLVRERGLAQDSSGFIFGAITAVAGLLGTVAGGWLGDKLDRKREGGGLWMSGIGLMLAAPCMYLAVSLKAVGPTFAAIALAQFLIFLNSGPINAAIVNCVPPAFRAFAMGLNVLCIHLLGDAISPTLIGTIADASSLHTAIAVNALPVLLGGFALLLGARLFREAVPLARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0M6</accession>
    <name>Q1D0M6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative batE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555612.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5659"/>
    <dbReference type="EnsemblBacteria" id="ABF92475">
        <property type="protein sequence ID" value="ABF92475"/>
        <property type="gene ID" value="MXAN_5659"/>
    </dbReference>
    <dbReference type="GeneID" id="41362904"/>
    <dbReference type="KEGG" id="mxa:MXAN_5659"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080147_0_0_7"/>
    <dbReference type="OMA" id="APSIYYY"/>
    <dbReference type="OrthoDB" id="1776664at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25136" checksum="40F05524DE93E1AE" modified="2006-07-11" version="1">MSGYYTPEEAQDIFLKANEAYAQEDYAAAKEGYEKLLANGQGGPDVLYNLGTTHLAQGDVGRAVLALEQARKEGGQAPDLEANLSVARARQVDKVVGATAEDAFLPRVAAATDGPVVAWTFLGTWVAAFVLVLLWRLLGRGRRTAVGVLAVLLFAVAVPSGLLVATHAYVGASVHEAVVLAPTLVARELPQPGARSIFEVHAGLKVRLLEETGRFVRIRLPNGLEGWAEREGVAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V5</accession>
    <name>Q1D0V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lysyl-tRNA synthetase-related protein GenX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5579"/>
    <dbReference type="EnsemblBacteria" id="ABF87474">
        <property type="protein sequence ID" value="ABF87474"/>
        <property type="gene ID" value="MXAN_5579"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5579"/>
    <dbReference type="eggNOG" id="COG2269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_1_0_7"/>
    <dbReference type="OMA" id="EWYRPGF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004525">
        <property type="entry name" value="EpmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00462">
        <property type="entry name" value="genX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="346" mass="38305" checksum="FFF029815B5C5164" modified="2006-07-11" version="1">MHVAPHVTCALPMPNLSQWRAARGRQSLYSALRRFFAAHGYLEVETPLLIPTPGMEPHINAFEAGFIPETDVGSARTLYLHSSPEYAMKRLLADGAGPLFQLCKVFRNGEVSPTHNPEFTMLEFYRPHADYHAIMDDLEGALAEAGRGATEGEPGADPLFFTRTPYERLTVRDAVLRATGVDIRQHSDGPSLKRAAEAAGVRTGNAETFDDVFFHLFLQKVETGLGHERPTFLIEYPASMAALSRLKPGDAVVAERVELYAKGLELANGFSELTDPVEQRARLTEEQELRRQLGRAVYPLDERFLDAVGRMPPSAGIAVGLDRILMLLLGVQRISDVLLFPAHEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Y4</accession>
    <name>Q1D0Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5550"/>
    <dbReference type="EnsemblBacteria" id="ABF87928">
        <property type="protein sequence ID" value="ABF87928"/>
        <property type="gene ID" value="MXAN_5550"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5550"/>
    <dbReference type="eggNOG" id="COG4757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2207188_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="11492" checksum="EEF975B6BF61E75C" modified="2006-07-11" version="1">MTGSGGRGMPAHPEPHHGEPTSLRASDGFSLGASRFAATAPLVDASSSRARPARRGFETLTFDYRGIGRPSSSPTRAAAMRWGAYNMLDLNNVRPVDAPRRRRPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D125</accession>
    <name>Q1D125_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555463.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5505"/>
    <dbReference type="EnsemblBacteria" id="ABF87160">
        <property type="protein sequence ID" value="ABF87160"/>
        <property type="gene ID" value="MXAN_5505"/>
    </dbReference>
    <dbReference type="GeneID" id="41362759"/>
    <dbReference type="KEGG" id="mxa:MXAN_5505"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198743_0_0_7"/>
    <dbReference type="OMA" id="CRFISKP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="25387" checksum="CCCE8D72A2CED60C" modified="2006-07-11" version="1">MDAFKVLVVDDEQPIARALQRLLKREGFEVQIAFNGNEALERLEGFSPDIVLTDFRMPGMTGSELLQRLKRSHPLALRLIISGYADFKSVVASVNEGEICRFISKPWDDAELVTYLKGLLRHRETMACLYAPFRQAPDGVNAEVGMSAASMVLKVQVADPSFPADQAVALIERFAGLLADDRLKVVGGLLERYGGRLSFMADVGGPQRLRLEVPMPTLETVNALRPGASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1A3</accession>
    <name>Q1D1A3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555385.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5423"/>
    <dbReference type="EnsemblBacteria" id="ABF89817">
        <property type="protein sequence ID" value="ABF89817"/>
        <property type="gene ID" value="MXAN_5423"/>
    </dbReference>
    <dbReference type="GeneID" id="41362685"/>
    <dbReference type="KEGG" id="mxa:MXAN_5423"/>
    <dbReference type="eggNOG" id="COG1926">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_7"/>
    <dbReference type="OMA" id="VIVIQRI"/>
    <dbReference type="OrthoDB" id="756161at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="229" mass="24448" checksum="40337E4792B420FC" modified="2006-07-11" version="1">MSFEDRVDAGRRLAQLLRERGYTGEGTLVLALPRGGVPVAFEVATALGAPLDVWVVRKVGVPGYEELGLGAVAEGGVAFVNRRLMDEVGVTEEDMQGLVRQKTDEVKVRVARFRQGIEAPRIEGQRIILVDDGIATGGTVRAAIQALRMHRPGSIILAVPVAASQTLAELAPLADDVVCVLSTPSLYAIGQWYADFQQVPDEAVATLLAQARLTLGHDRHAPPGDTAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1G3</accession>
    <name>Q1D1G3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5360"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87230">
        <property type="protein sequence ID" value="ABF87230"/>
        <property type="gene ID" value="MXAN_5360"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5360"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_5_1_7"/>
    <dbReference type="OMA" id="TQIDHDY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="114"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="588" mass="65424" checksum="61CC56E94CD05663" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D216</accession>
    <name>Q1D216_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase, truncated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555125.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91304">
        <property type="protein sequence ID" value="ABF91304"/>
        <property type="gene ID" value="MXAN_5154"/>
    </dbReference>
    <dbReference type="GeneID" id="41364896"/>
    <dbReference type="KEGG" id="mxa:MXAN_5154"/>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2181030_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="12484" checksum="F7C138D3D605C58A" modified="2006-07-11" version="1">MAWQPRRPSAEQQQERVARELRVSEAAISKWAARLRSGGLRALRARRHPGQPSRLTPTQWQQVATILRAGTLVAGFPTERWMLRRVAQVIMVRGYAAGTYNLTLTYRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D223</accession>
    <name>Q1D223_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cheA3</name>
        <name evidence="10" type="ORF">MXAN_5147</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555118.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5147"/>
    <dbReference type="EnsemblBacteria" id="ABF90293">
        <property type="protein sequence ID" value="ABF90293"/>
        <property type="gene ID" value="MXAN_5147"/>
    </dbReference>
    <dbReference type="GeneID" id="41362430"/>
    <dbReference type="KEGG" id="mxa:MXAN_5147"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_2_1_7"/>
    <dbReference type="OMA" id="LREPLMH"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="321"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="525"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="680"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="798" mass="84758" checksum="782B77F7F2C7EF97" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D2</accession>
    <name>Q1D2D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555012.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5036"/>
    <dbReference type="EnsemblBacteria" id="ABF87781">
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        <property type="gene ID" value="MXAN_5036"/>
    </dbReference>
    <dbReference type="GeneID" id="41362321"/>
    <dbReference type="KEGG" id="mxa:MXAN_5036"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620855_0_0_7"/>
    <dbReference type="OMA" id="MAQAHRM"/>
    <dbReference type="OrthoDB" id="781431at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="441" mass="48253" checksum="E1A9F4E7C768CD39" modified="2006-07-11" version="1">MHRLFRIRPWTLALLPLLACKEPEVAAAENQAKRAQAALTEARGHLSSGQANAALAALSRAATAAPDNPEPHLLMAQAHRMAGNEGAAILALKQAASMLPGSDPTIQRQLADIYLQQGLTKDALAALITMRDAGNLPDADVLRLARIQAREGMIDAAFKTLENILRENPDDAEAKSVEAEVLWLKGDELLAANLMDRLLNQDPALASARLLRARYFLVSGFPDLAESDLNAVKGADAERPEVVTLRARVLLALGRAADAEEALRGLVEAQPQNADALAWLAETVRVQGRRADAQSLVDQALQLNPRLARAQYVRGRSLEEQGDRRGAEEAYRFALSAEPRFAPVHARMWRIHLNADRITDAETSLELLLSMSEATIEEKAQLAALYARMQTKVTQGLKLIDEALKREPENPDYLRTQKALNALLPKPKKKSSGPIIIRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2I0</accession>
    <name>Q1D2I0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554965.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4987"/>
    <dbReference type="EnsemblBacteria" id="ABF90061">
        <property type="protein sequence ID" value="ABF90061"/>
        <property type="gene ID" value="MXAN_4987"/>
    </dbReference>
    <dbReference type="GeneID" id="41362271"/>
    <dbReference type="KEGG" id="mxa:MXAN_4987"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_4_7"/>
    <dbReference type="OMA" id="YRAWLCR"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="22211" checksum="086500BBC34871ED" modified="2006-07-11" version="1">MSGQRIATVIRIPVAYSTDVHPDGFEEFAHRVRPMLLALARRLCGQGGIDPEDLVQEALTRGLLHHGALAAQPEPVYRAWLCRAMTNHFLDQCRKRRSELLEQDRPELRLVREGVAAPEPEAMEVWEHISAKDFKAAIAQLSNPRVREAYSLHASGLRYRAIALRMGVPEGTVGSWLYQARKELKALLLPLTGSDGGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2N0</accession>
    <name>Q1D2N0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EGF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554915.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4937"/>
    <dbReference type="EnsemblBacteria" id="ABF86707">
        <property type="protein sequence ID" value="ABF86707"/>
        <property type="gene ID" value="MXAN_4937"/>
    </dbReference>
    <dbReference type="GeneID" id="41362221"/>
    <dbReference type="KEGG" id="mxa:MXAN_4937"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796520_0_0_7"/>
    <dbReference type="OMA" id="ECANGTA"/>
    <dbReference type="OrthoDB" id="1080840at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="EGF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13948">
        <property type="entry name" value="DUF4215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="41206" checksum="24D5621D933007A1" modified="2006-07-11" version="1">MLSNGTRVLDSKCVPLKLKMEFMRSLLWRLSGVTVLTSDRHPQVEADWSKTMKVSRVAPMWRMLSAALAFGMMSACGSELEDESVVSEEAPVGGESSSDSASAMAGDRYANAVVQSGVIAVLNPNNAVGAPDGNAATFLGLLGGSMVLDMGLGEEGTGPLRVYYQGLSLAVIAQVEFLRGDMSIISTGQANLLDLGLGTHSTLVPFSSSTPYRYVRLRGGVASLYGLDAVEDTGGGASAVCGDGRINNGEQCDDGNRVSSDGCSSTCRVEPGYTCNGMQPSVCTDVNECTNGTAQCSVNAICTNTPGSYTCTCRPGYWGNGWTCSDIDECSNGTAACNPSQVCVNTPGGYECVGGSCPAPRVQCGAQCVDVSSDVNNCGACGVVCPAAKTCSSGVCVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2S8</accession>
    <name>Q1D2S8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pgm</name>
        <name evidence="14" type="ORF">MXAN_4888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554870.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4888"/>
    <dbReference type="EnsemblBacteria" id="ABF87505">
        <property type="protein sequence ID" value="ABF87505"/>
        <property type="gene ID" value="MXAN_4888"/>
    </dbReference>
    <dbReference type="GeneID" id="41362179"/>
    <dbReference type="KEGG" id="mxa:MXAN_4888"/>
    <dbReference type="eggNOG" id="COG0033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_8_1_7"/>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="11">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="12">
        <location>
            <begin position="208"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="13">
        <location>
            <begin position="319"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="10">
        <location>
            <begin position="474"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="58652" checksum="4A1AF7B0596D15E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D320</accession>
    <name>PSTB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate import ATP-binding protein PstB</fullName>
            <ecNumber evidence="1">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ABC phosphate transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstB</name>
        <name type="ordered locus">MXAN_4791</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D320"/>
    <dbReference type="SMR" id="Q1D320"/>
    <dbReference type="STRING" id="246197.MXAN_4791"/>
    <dbReference type="EnsemblBacteria" id="ABF87523">
        <property type="protein sequence ID" value="ABF87523"/>
        <property type="gene ID" value="MXAN_4791"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4791"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000272481" description="Phosphate import ATP-binding protein PstB">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="247" mass="27295" checksum="665EB88D10756E52" modified="2006-07-11" version="1">MEARELSLRYGPKTAIHKVSLAILDRRVTALIGPSGCGKSTFLRSLNRMNDLISGTTHSGTILLDGTDIHDRGVDVVDLRRRVGMVFQKSNPFPKSIFENVAYGLRVGGMKDKAELATRVEKSLRGAALWDEVKDRLDESALGLSGGQQQRLCIARAMAVEPEVLLMDEPASALDPIATAKIEELIHELKSTYTIAIVTHNMQQAARVSDRTAFFYMGELVECGPTEQIFTNPREKRTEDYVTGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D327</accession>
    <name>Q1D327_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inorganic anion transporter, sulfate permease (SulP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554771.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4784"/>
    <dbReference type="EnsemblBacteria" id="ABF89758">
        <property type="protein sequence ID" value="ABF89758"/>
        <property type="gene ID" value="MXAN_4784"/>
    </dbReference>
    <dbReference type="GeneID" id="41362083"/>
    <dbReference type="KEGG" id="mxa:MXAN_4784"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_11_2_7"/>
    <dbReference type="OMA" id="GCWFRVT"/>
    <dbReference type="OrthoDB" id="751256at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="7">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="515" mass="52331" checksum="4E85DE097BEA25F4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D328</accession>
    <name>Q1D328_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cynT</name>
        <name evidence="6" type="ORF">MXAN_4783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554770.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4783"/>
    <dbReference type="EnsemblBacteria" id="ABF88656">
        <property type="protein sequence ID" value="ABF88656"/>
        <property type="gene ID" value="MXAN_4783"/>
    </dbReference>
    <dbReference type="GeneID" id="41362082"/>
    <dbReference type="KEGG" id="mxa:MXAN_4783"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_5_3_7"/>
    <dbReference type="OMA" id="WHYIIET"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00884">
        <property type="entry name" value="beta_CA_cladeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045066">
        <property type="entry name" value="Beta_CA_cladeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="26811" checksum="40B6EFDD0B00FC71" modified="2006-07-11" version="1">MRKLIRGLLDFQLNARSSYREKFALLAQEQKPDCLFIACADSRVVPNLLVSMDPGDLFVVRNVGNMVAPSDSKGQSTGDQSEAAALEFSLRSLPVEDIVVCGHSNCGAMKAVLAGGVGPENPNLKSWLEHGKAALQRMDANPTLGEGRSDYDRLSQNNVLLQLEHISTYPLVKERLDAGTLRLHGWWFDIATAQVHAWRPLLGRFIPMDELVGEALLRELGTDTHAPGALANGNGAQRMSVVARAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3E7</accession>
    <name>Q1D3E7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus biogenesis protein, TadE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554652.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4660"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90306">
        <property type="protein sequence ID" value="ABF90306"/>
        <property type="gene ID" value="MXAN_4660"/>
    </dbReference>
    <dbReference type="GeneID" id="41361960"/>
    <dbReference type="KEGG" id="mxa:MXAN_4660"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090593_0_0_7"/>
    <dbReference type="OMA" id="NNERMHD"/>
    <dbReference type="OrthoDB" id="479585at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="37242" checksum="42DA039F72612FBF" modified="2006-07-11" version="1">MGQEAQEPRAQGASRRQSGQAAVEAAMIMPLAVFMTLGIIQLTMMQHAKLMTEYAAYQAARAGIVWNGNNERMHDAAIVALLPTMGRTDDIVELGKTFVLHQLYDSGMRMLNFGGGRVPRTVNGSNLFGVIRVDTVSPAYFTPIDSMWKLRSGYNWQELDFDGADSFPEVPSLENHIRKFFNLPEPDDAELVFRKSTRLTIRLRYWYQLRVPFANSIIFYSWFASNAGMALRGAIDRGTVDPRANMMNRRGNLNPLLAGARGIEHEMGYDSVYPLEMTVLWMLANGSIPIVSNLAGKRYFMPLTATYSMRMQSNFHRKWIMHLNPDWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K9</accession>
    <name>Q1D3K9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554591.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4596"/>
    <dbReference type="EnsemblBacteria" id="ABF86893">
        <property type="protein sequence ID" value="ABF86893"/>
        <property type="gene ID" value="MXAN_4596"/>
    </dbReference>
    <dbReference type="GeneID" id="41361896"/>
    <dbReference type="KEGG" id="mxa:MXAN_4596"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_2_7"/>
    <dbReference type="OMA" id="HHICWDD"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2048" mass="226431" checksum="F089893291CE3588" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L1</accession>
    <name>Q1D3L1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554589.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4594"/>
    <dbReference type="EnsemblBacteria" id="ABF87295">
        <property type="protein sequence ID" value="ABF87295"/>
        <property type="gene ID" value="MXAN_4594"/>
    </dbReference>
    <dbReference type="GeneID" id="41361894"/>
    <dbReference type="KEGG" id="mxa:MXAN_4594"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841093_0_0_7"/>
    <dbReference type="OrthoDB" id="1775566at2"/>
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        <location>
            <begin position="178"/>
            <end position="344"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF87295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="38656" checksum="4D52F48CAE6D6DA4" modified="2006-07-11" version="1">MDCPRKTGQARTMNLVPFANEHLEAAASLLALRHRAHRATLPLLPGEPESATEARRILEALRQRPRTSGFAALQNGRLIGFALGTLRIDTTWGRSAWLFAPGHALAPGTSPEVYRDLYAALAAQWVQEGCFVHAALVPAHDRPALEAWYGAGFGHEQVHSLRSLDPVDLRPGVLDSPLRLRRAGMDDLDRLLEMAGLISEHQRASPVFAPYLPEFSKDWPQDYTELIEGEADRIWLAEQDGRLLGFAIFSPAEQPPDEVLTPPKSVTFTVGVTREDVRCRGVGRALFARGVEEAGRMGFRACVTDWRATNLTASRAWPRMGFSPALYRLTRRIDERVAWARGARSTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3N3</accession>
    <name>Q1D3N3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4572"/>
    <dbReference type="EnsemblBacteria" id="ABF89466">
        <property type="protein sequence ID" value="ABF89466"/>
        <property type="gene ID" value="MXAN_4572"/>
    </dbReference>
    <dbReference type="GeneID" id="41361873"/>
    <dbReference type="KEGG" id="mxa:MXAN_4572"/>
    <dbReference type="HOGENOM" id="CLU_1561264_0_0_7"/>
    <dbReference type="OMA" id="AETQACD"/>
    <dbReference type="OrthoDB" id="1719531at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187848" evidence="2">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17252" checksum="690842DB94CEF776" modified="2006-07-11" version="1">MWTMRGWKVTLLCGWLAAPVALAETAMLDGVPREARAARGAELLPSESMFPDAGPGEVDGPVLRYAEPLSCPAAPEGRVWVAETQACDDAGCESLTTVWAGSWTVEDAGLEVRCETDRVVLAAGEWRMVLTPGAGGGLEVSELTPPEPESLSAARPSETPASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3P8</accession>
    <name>Q1D3P8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine kinase family protein</fullName>
            <ecNumber evidence="4">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554552.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4557"/>
    <dbReference type="EnsemblBacteria" id="ABF90050">
        <property type="protein sequence ID" value="ABF90050"/>
        <property type="gene ID" value="MXAN_4557"/>
    </dbReference>
    <dbReference type="GeneID" id="41361858"/>
    <dbReference type="KEGG" id="mxa:MXAN_4557"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288009_0_0_7"/>
    <dbReference type="OMA" id="AYILMEY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="395"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="891"/>
        </location>
    </feature>
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        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1056" mass="111709" checksum="A880519601E35CC2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T9</accession>
    <name>Q1D3T9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4516"/>
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    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4516"/>
    <dbReference type="HOGENOM" id="CLU_2735824_0_0_7"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="71" mass="7804" checksum="66AF6AD34C1CFD98" modified="2006-07-11" version="1">MSLEMNRALIFRAKRHEALASSVQLSLESTPSRCAPSSRRRRSWPCAPSNSDRPARAQGGSVYLSGGTDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U1</accession>
    <name>Q1D3U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554509.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4514"/>
    <dbReference type="EnsemblBacteria" id="ABF90019">
        <property type="protein sequence ID" value="ABF90019"/>
        <property type="gene ID" value="MXAN_4514"/>
    </dbReference>
    <dbReference type="GeneID" id="41361821"/>
    <dbReference type="KEGG" id="mxa:MXAN_4514"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_1_0_7"/>
    <dbReference type="OMA" id="DWQIGKP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014577">
        <property type="entry name" value="UCP033093_metalloPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033093">
        <property type="entry name" value="UCP_ML1119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="375" mass="40175" checksum="D350883FE6046896" modified="2006-07-11" version="1">MVRILHSADWQMGLRARHVAHVAEDVRKARLEAASNVISAANRSKVDAVVLAGDIFEHNVVEDRVVHAVIKVLAGSLAPVYVLPGNHDALTPDAVFRRASWNQRPDHITVLDGNAAVPIPHTDAVLLPAPLRQKKGMKDPTAGWEMASGLDVIRIGVAHGSLRIEGKHAADDFPIALDAAVRAGLDYLALGHWHGQYVHDGRTAYSGAHETTKFGEVGSGQALLVELSSRGAVPRLEPIATGALTWRTVELDLSQGHEPEVARARELVAQLARPERALLRIHTTGFSSEDASSGLEAFREELQGGGLLHVCIEREDIPRAKAEGRLADIAGSSSLVSSLLDGLNKPAAVGPGATPEPVRTAARQLLSELVMEVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3X1</accession>
    <name>Q1D3X1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554479.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4483"/>
    <dbReference type="EnsemblBacteria" id="ABF91270">
        <property type="protein sequence ID" value="ABF91270"/>
        <property type="gene ID" value="MXAN_4483"/>
    </dbReference>
    <dbReference type="GeneID" id="41361793"/>
    <dbReference type="KEGG" id="mxa:MXAN_4483"/>
    <dbReference type="HOGENOM" id="CLU_078790_0_0_7"/>
    <dbReference type="OMA" id="QCHEENA"/>
    <dbReference type="OrthoDB" id="1095639at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011754">
        <property type="entry name" value="Mxa_paralog_2268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09544">
        <property type="entry name" value="DUF2381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02268">
        <property type="entry name" value="TIGR02268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188202" evidence="2">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="33377" checksum="29950CD5D99B7CF5" modified="2006-07-11" version="1">MPASPIAFFVVLVLASGAATAQPSPTVSGLGVRRVEISAEPSSAVPPPEVQISPRMSTSFEFDSALDPAKVVLEGEERFSLVDLGRSTLRLVPSEQLLPGERLLLTVRFQDGSVPLDAAFVLVAHPARGERIVEVWRQARTAESYQQEAKEARAETQQCHEENARMRAEQREPSGIAGLLANGVIQKEEGVAAKLLRVNEEVRQHPGNALWAHRAWSYRAPVRVAVAVEFENPDAANPWTAEGASLVSKPGTSLKILTVWQKAPISRYPFGRVVVEAEATPDAAQGPFTLKLWGPGGLRAITLSGVTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3X8</accession>
    <name>Q1D3X8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88479">
        <property type="protein sequence ID" value="ABF88479"/>
        <property type="gene ID" value="MXAN_4477"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4477"/>
    <dbReference type="HOGENOM" id="CLU_1446225_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="20689" checksum="4F4C100BC25E8CE1" modified="2006-07-11" version="1">MLPRQAPPSLIDLSRRRSPDLFVRQEREQQLVVGGERTPAGRWWLGEERCADLSCSVLMSIWGVGNPRTERLGDFEAVGVIQHGRPAVGETFGQLAHKYVANKACDLLALLRLAKQSAQYLHCCNVILSKLFGQQVQRDGRTRLGKGGERIVAVLADPLIQACLHVALPGTLVAHRPLQRVKFIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Y4</accession>
    <name>Q1D3Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554466.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D3Y4"/>
    <dbReference type="STRING" id="246197.MXAN_4468"/>
    <dbReference type="EnsemblBacteria" id="ABF88882">
        <property type="protein sequence ID" value="ABF88882"/>
        <property type="gene ID" value="MXAN_4468"/>
    </dbReference>
    <dbReference type="GeneID" id="41361778"/>
    <dbReference type="KEGG" id="mxa:MXAN_4468"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="KPLDMGQ"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14124" checksum="039D7A2BBE872C2A" modified="2006-07-11" version="1">MARPGAALSPVNILVVDDDLELCTMLSRFLEMHGFTVYSASDALQALDVLERNQVSMVITDYVMPHMDGIQFTEMLKADPRFQSVPVLLMTGSEDGSVTDRGLRKGVALTLHKPLDMGQLLTLVRFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D480</accession>
    <name>Q1D480_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554371.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4370"/>
    <dbReference type="EnsemblBacteria" id="ABF92526">
        <property type="protein sequence ID" value="ABF92526"/>
        <property type="gene ID" value="MXAN_4370"/>
    </dbReference>
    <dbReference type="GeneID" id="41361681"/>
    <dbReference type="KEGG" id="mxa:MXAN_4370"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="26953" checksum="86C562E3DA28731F" modified="2006-07-11" version="1">MDTELQGRGVLVTGGAGGIGTALVHTFAEEGAKVAVHHHSSTEKAQALARDVGGAALRADLTVEADVDALVPAAVAALGRLDVLVCNAGVWPAPDEPVWEMSLARWRRTLAENLDSVFLCCRAFLRHVATTKTGNIVIISSTAGLFGEAGHADYAAAKGALASGFLKSLKNELGRIAPLGRVNVVCPGWTAVDRSRDKLAQPGFVERVTRTMPLRKVAQPVDVARAVVSLASDRISGHVTGEVVTVAGGMEGRVLHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D483</accession>
    <name>Q1D483_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554368.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89291">
        <property type="protein sequence ID" value="ABF89291"/>
        <property type="gene ID" value="MXAN_4367"/>
    </dbReference>
    <dbReference type="GeneID" id="41361678"/>
    <dbReference type="KEGG" id="mxa:MXAN_4367"/>
    <dbReference type="HOGENOM" id="CLU_933269_0_0_7"/>
    <dbReference type="OMA" id="REDGWYS"/>
    <dbReference type="OrthoDB" id="1650405at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="35663" checksum="1154524D1CCFC082" modified="2006-07-11" version="1">MGAWRRMGGPAFSDEVLMRVFPLLAVAVLFFGCGARSGRVKPEGPESTVAVPDDAELRRVQTRAKYLFDAERAAIFATDRLLIQDALDRSRMEWFFTLPREDGWYSLFGTLDDAGTFTPAYAFKAPRDDAEQMASLPLNELPGDFSPVARAVKTSMLATVEAFERGSINPVVFVEEDGDLTVYVLQGTRDPMRFYLGGDIRFRYSPDGRTQREAVRLHQSVFAISLEPGPEGELYQGSAHSHVLFGGPLETELATLMLYPELGALTVIHAASRIAYFLTPDGAIRVLSEVPERQRTLRPDGTFGPLDMEEEAAPPPPSGQVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4I7</accession>
    <name>Q1D4I7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554264.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4261"/>
    <dbReference type="EnsemblBacteria" id="ABF90998">
        <property type="protein sequence ID" value="ABF90998"/>
        <property type="gene ID" value="MXAN_4261"/>
    </dbReference>
    <dbReference type="GeneID" id="41361576"/>
    <dbReference type="KEGG" id="mxa:MXAN_4261"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="CATHQNL"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="145"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="452" mass="49854" checksum="14C4E7117E18FD78" modified="2006-07-11" version="1">MSVEGRILVVDDHVDMGLMLREPLTDAGYVVDLATGGEAAIRMARAQAYDAVLCDLRMEGVDGLDVLEAVRALDSDIPVLMMTAFGGVESAVEAMKRGAYHYFTKPFRLDEVLLFLERALKERRLQVENRALRRAAAERSGLGALVGRSAAMRNLYELIDRVAYAQAAVLLRGPSGTGKELVARALHFQGPRASGPFVAVNCTALPHDLLESELFGHLKGAFTGATHARRGLFVEADGGTLFLDEIGDMPLELQARLLRVLEDGEVRAVGADGSRTVDVRIVAATHQDLDARVREGRFRADLFYRLNVVTLLLPPLAERREDIPLLVEHFTARARARNPRSRMQSLSPEAVAALATLPWPGNVRELENLIERLAVMVASEVVGLEELRPHLPPEAPEVQPLVMAQHALWPLRRLEAEYIAWMVTRCGGNKTRAAEVLGIDVSTIHRRERERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4P6</accession>
    <name>Q1D4P6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554205.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4202"/>
    <dbReference type="EnsemblBacteria" id="ABF86076">
        <property type="protein sequence ID" value="ABF86076"/>
        <property type="gene ID" value="MXAN_4202"/>
    </dbReference>
    <dbReference type="GeneID" id="41361519"/>
    <dbReference type="KEGG" id="mxa:MXAN_4202"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1523569_0_0_7"/>
    <dbReference type="OMA" id="PLHGFES"/>
    <dbReference type="OrthoDB" id="1657308at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="20247" checksum="1ED3171525BD2976" modified="2006-07-11" version="1">MPWVGRVRHLLVVEDATRLARAIEEALRSRVERCTHAASLAAARQVLQCDAPDAVILDVSLPDGDSIELLAPLCELEPLPHVIAISGTATAEQAFQLAQEGVRAFLPKPLDLARLESVWLETLARPPDLVTALRASAGRVPLHGFESLVRDTLVDEALAKSEGSVRGAAKLLRISRQLLQHILGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S2</accession>
    <name>Q1D4S2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554179.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4176"/>
    <dbReference type="TCDB" id="1.B.17.2.9">
        <property type="family name" value="the outer membrane factor (omf) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88538">
        <property type="protein sequence ID" value="ABF88538"/>
        <property type="gene ID" value="MXAN_4176"/>
    </dbReference>
    <dbReference type="GeneID" id="41361494"/>
    <dbReference type="KEGG" id="mxa:MXAN_4176"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616639_0_0_7"/>
    <dbReference type="OMA" id="QNEFKAR"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="48921" checksum="A58C688491A375C9" modified="2006-07-11" version="1">MNAFVIAVALAAAPSDSGTPITLDQARAEGRQNVAAIQAMLDVAIADEDVNLSRSVLLPQLSLDASAGKIWFGRRQEFTTVPDPANPGSFIRNAVETPSTSTQNYDLGLSLTQVIYDRARWKQLEQSGVVRDAQKGQAREEADTSELEAIRRFFTLYRTQATLQVLKATVERSEQQVERAQALFHAGRTGKNEEITATVNLGTDRINYTAMLGQLVNDQSQLAVWLARPGTEVLTAQDPGVLTTEPPPAPSVNEALASARAYRPLLRTLELRIRAAELKQSIARSEYLPRLMAQGLYNRGGPDASLVFTEPRLQNRFTAAVGLSWDLFTGLSTGASSRRAEADIRKAQLTLEQTAREIEGEVRAAHRTLEAQLEAARLAAQNVEVATQGLEMQEARFRAGAGSTLEVRDAQLSLTRAELALLENRIDVEIARYSLQRAMGALSPGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D663</accession>
    <name>Q1D663_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3673"/>
    <dbReference type="EnsemblBacteria" id="ABF89535">
        <property type="protein sequence ID" value="ABF89535"/>
        <property type="gene ID" value="MXAN_3673"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3673"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1893957_0_0_7"/>
    <dbReference type="OMA" id="CEHGVQK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14603" checksum="2C48E77DDADDB2F3" modified="2006-07-11" version="1">MCLARAVAGRARTSSRCAQALSDLPAHLRAGHHRRGHAPRQERLIMHSLRTLSVVLSLFAAPVLADESKPAQQPQTAGSEKPRCEHGVQKSLCARCNPKLAPVFKAKGDWCPEHARPESQCVLCNPELSKKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D665</accession>
    <name>Q1D665_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553689.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3671"/>
    <dbReference type="TCDB" id="2.A.6.1.10">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88339">
        <property type="protein sequence ID" value="ABF88339"/>
        <property type="gene ID" value="MXAN_3671"/>
    </dbReference>
    <dbReference type="GeneID" id="41361006"/>
    <dbReference type="KEGG" id="mxa:MXAN_3671"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="QVMMLKG"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111740" checksum="8547110BA2349017" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6I7</accession>
    <name>NDK_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name type="ordered locus">MXAN_3543</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553572.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6I7"/>
    <dbReference type="SMR" id="Q1D6I7"/>
    <dbReference type="STRING" id="246197.MXAN_3543"/>
    <dbReference type="EnsemblBacteria" id="ABF90253">
        <property type="protein sequence ID" value="ABF90253"/>
        <property type="gene ID" value="MXAN_3543"/>
    </dbReference>
    <dbReference type="GeneID" id="41360888"/>
    <dbReference type="KEGG" id="mxa:MXAN_3543"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_8_1_7"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000267790" description="Nucleoside diphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <sequence length="145" mass="16135" checksum="29EA957F3E473FBA" modified="2006-07-11" version="1">MAIERTLSIIKPDGLEKGVIGKIISRFEEKGLKPVAIRLQHLSQAQAEGFYAVHKARPFFKDLVQFMISGPVVLMVLEGENAVLANRDIMGATNPAQAAEGTIRKDFATSIDKNTVHGSDSLENAKIEIAYFFRETEIHSYPYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6T7</accession>
    <name>Q1D6T7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553472.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3439"/>
    <dbReference type="EnsemblBacteria" id="ABF91668">
        <property type="protein sequence ID" value="ABF91668"/>
        <property type="gene ID" value="MXAN_3439"/>
    </dbReference>
    <dbReference type="GeneID" id="41360787"/>
    <dbReference type="KEGG" id="mxa:MXAN_3439"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_7"/>
    <dbReference type="OMA" id="DWAFDHL"/>
    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="191" mass="21286" checksum="74940785098E871E" modified="2006-07-11" version="1">MPNTKALEMSHLASNGPVLETQRLILRPPLAEDLDGFAALSADPESARFIGGVQPRAMAWRTLCVMAGSWSLQGFAMFSVLEKSTGAWVGRVGPWQPEGWPGTEIGWGLLREYWGRGYATEATAATMDWAFDHLGWTDVIHCIVPENTPSQQVALRLGSRVLGQAHLPPPHDMLRVDRWGQSRDEWRARRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D759</accession>
    <name>RL18_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">MXAN_3315</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF88209" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88209.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026114014.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D759"/>
    <dbReference type="SMR" id="Q1D759"/>
    <dbReference type="STRING" id="246197.MXAN_3315"/>
    <dbReference type="EnsemblBacteria" id="ABF88209">
        <property type="protein sequence ID" value="ABF88209"/>
        <property type="gene ID" value="MXAN_3315"/>
    </dbReference>
    <dbReference type="GeneID" id="41360668"/>
    <dbReference type="KEGG" id="mxa:MXAN_3315"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_7"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251333" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="118" mass="12987" checksum="2EA3F4CC23319B59" modified="2006-10-03" version="2">MPTKIEARLKRKNRIRKKLSGTTERPRLTVYKSLKHIYAQVVDDTTGKTLAFASSLSKDLKGQDEGDKKADAKRVGALIAQKCKAANVEAVVFDRNGFPYHGRIAAVADAAREAGLKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D778</accession>
    <name>RS7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">MXAN_3296</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553340.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D778"/>
    <dbReference type="SMR" id="Q1D778"/>
    <dbReference type="STRING" id="246197.MXAN_3296"/>
    <dbReference type="EnsemblBacteria" id="ABF92834">
        <property type="protein sequence ID" value="ABF92834"/>
        <property type="gene ID" value="MXAN_3296"/>
    </dbReference>
    <dbReference type="GeneID" id="41360649"/>
    <dbReference type="KEGG" id="mxa:MXAN_3296"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_7"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000014241" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17958" checksum="187523FFC527EE19" modified="2006-07-11" version="1">MPRRRVVAKRKILPDPKFQDRLVTKFVNDLMRKGKKSIAEGVCYGAFALIEERAKEDPLKTFKKALDNVKPVLEVKSRRVGGATYQVPVEVRQDRRVALGMRWIITYSKARGEKTMQEKLAGEIMDAANNRGNAVKKREDTHKMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A8</accession>
    <name>Q1D7A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553311.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3266"/>
    <dbReference type="EnsemblBacteria" id="ABF89335">
        <property type="protein sequence ID" value="ABF89335"/>
        <property type="gene ID" value="MXAN_3266"/>
    </dbReference>
    <dbReference type="GeneID" id="41360618"/>
    <dbReference type="KEGG" id="mxa:MXAN_3266"/>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860042_0_0_7"/>
    <dbReference type="OMA" id="DMRVRRE"/>
    <dbReference type="OrthoDB" id="2047341at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="37113" checksum="BBFCB7B1A84D996C" modified="2006-07-11" version="1">MSSTPAAAALRPLAMGEMIDRAATFWRSHLKPLFLLSFGFTLVNYIATKATLVIGQRLAPLLYTGDAESRAQLDPAVMLPQASITIALWMSLFLFLVWMYWLATLAASRYVLTSQLGEPVRPADALRRSFSRLGTLTGVYLLSLGWSALVTMALMLPGLILAIIGIAVGVASGSNTLAVVLGVVGTLLASLGLLAAALWYMLRFLLVPPVLAMEDLGAWETFRRSGQLLSGRVEPGFMGRVMVRAMILFTVVSLILISVQLVSGLPSWLVMMPYGSPFDPGTMARTPQLLLVPVELLQTVAQSFFTPINFVFCALFYLDMRVRREALDLEHQLNTMTPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E4</accession>
    <name>Q1D7E4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3230"/>
    <dbReference type="EnsemblBacteria" id="ABF91712">
        <property type="protein sequence ID" value="ABF91712"/>
        <property type="gene ID" value="MXAN_3230"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3230"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_1_7"/>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="34145" checksum="3A292AECF548B693" modified="2006-07-11" version="1">MDRPTRIVAIGGGTGLPMVLRGLARRATPKAREPGIDITAVVAMSDDGGSSGRLRRQHGALPPGDIRNCLVALAGGKNALKDVFQFRFGGARGLAGHAVGNLLIAALAELKGDFMEAVRMSGELLGARGHVLPSTLASVQLVAQMHDDTEVVGERNICRAHGRVRRVTLSPRSPPPTEGLLEAIYTADLIAIGPGSLYSSVLPNLLVDGVAQALKETRALKVMVANLMTQPGETDGMSCLDHVQAVTDHVGPVLDAVLVNGTLPTEEATRRYARRGSFVVSANPRDLIGAGVVPVHADLLKAGSRIRHDSRKVAACLLKMARSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D838</accession>
    <name>Q1D838_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">tyrS</name>
        <name evidence="11" type="ORF">MXAN_2976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553032.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2976"/>
    <dbReference type="EnsemblBacteria" id="ABF91128">
        <property type="protein sequence ID" value="ABF91128"/>
        <property type="gene ID" value="MXAN_2976"/>
    </dbReference>
    <dbReference type="GeneID" id="41360339"/>
    <dbReference type="KEGG" id="mxa:MXAN_2976"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_5_0_7"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="359"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="420" mass="46656" checksum="28C5BAFB8C2B6212" modified="2006-07-11" version="1">MNPDALRKATPEEQFEEVTRGTVDLHVPEDLKKKLQYSYDTGKPLVIKAGFDPSRPDLHLGHSLLLTRMRRFQEFGHTVVFLIGDFTGLIGDPTGRNATRPALTRDEVKANAETYKKQVFKVLDESKTQVRFNSSWLDSLGTEGMIRLASRYSVQRMLERDDFKKRFRGEVSISIHEFLYPLLQGYDSVVLKADVELGATDQLFNLLVGRQLMKEEGMAPQVIMTGPILEGLNAKAVDGKIVGDKMSKSLDNYVGIDEPADTIFGKLMSITDDLMWRYYELLSAKTRAELAEMRAQVESGALHPKAVKVGFAQEMTARFQGEEAGKKAAEDFEKRFAKKELSTDELPLVEVSLGGAEKLPVTKLLPESKLVASATEARKLMAQGGVRVNGEKVQDVKAELGAGEYTVQVGKLKAARVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D864</accession>
    <name>Q1D864_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cation ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553006.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2949"/>
    <dbReference type="EnsemblBacteria" id="ABF86966">
        <property type="protein sequence ID" value="ABF86966"/>
        <property type="gene ID" value="MXAN_2949"/>
    </dbReference>
    <dbReference type="GeneID" id="41360312"/>
    <dbReference type="KEGG" id="mxa:MXAN_2949"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_7"/>
    <dbReference type="OMA" id="IAVLHDF"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="270" mass="29412" checksum="D8AEF9276D935D7D" modified="2006-07-11" version="1">MKTVEPTNGAHAVPATFAPGDALLTCEKLVIGYDSKAILPPIDLTIRRGQFVAVVGRNGSGKSTWFRTLLGMQPPVSGTISRASAQVRSAYVPQTSAIDSLLPLRAGELTAWGRLRGWSFLWPFARKADRQAVQSALETAGAKAFASRPYRELSEGQKQRTLLARLVATEADLVLLDEPTAAMDAVAEHETMQRLCTLSRERGLGVVVVCHDLEVAAEHADVLVFVDRETSAFVVGDARTVFCHPAFRRQYGDEYCQRAPLGPHRGNDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8S6</accession>
    <name>Q1D8S6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoC</name>
        <name evidence="4" type="ORF">MXAN_2730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2730"/>
    <dbReference type="EnsemblBacteria" id="ABF88304">
        <property type="protein sequence ID" value="ABF88304"/>
        <property type="gene ID" value="MXAN_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2730"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_2_7"/>
    <dbReference type="OMA" id="KDIFRGP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="3">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="18140" checksum="266D355B6BA359B2" modified="2006-07-11" version="1">MDRTGGAWAVIHADSLPKVAAFLKNDPELEFKLFGSIDAVDRLHLAENDPRFEVVYFLYSLKRHEHVRLKVRVSEANPVVPTLVPLFRGANWWERLTFDFYGIRFDGHPDLRRILLYDEFEGHPLRKDYALRDRQPLIPERPIKDIFRGPGTSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D902</accession>
    <name>Q1D902_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trx</name>
        <name evidence="7" type="ORF">MXAN_2652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552722.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2652"/>
    <dbReference type="EnsemblBacteria" id="ABF91755">
        <property type="protein sequence ID" value="ABF91755"/>
        <property type="gene ID" value="MXAN_2652"/>
    </dbReference>
    <dbReference type="GeneID" id="41360028"/>
    <dbReference type="KEGG" id="mxa:MXAN_2652"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_7"/>
    <dbReference type="OMA" id="KIKICKF"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="110" mass="11989" checksum="DF3C94565DB1C17E" modified="2006-07-11" version="1">MAGADVTNIGDGDFKQQVLDSQEPVLVDFWATWCAPCRAIAPSIEALASQYKGQVKFAKLNIDENQDTPQEYGIRSIPTLLLFKGGRVVEQIVGAVPKARIEEAVKKALT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V4</accession>
    <name>PUR4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <shortName evidence="1">FGAMS</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase</fullName>
            <shortName evidence="1">FGAR amidotransferase</shortName>
            <shortName evidence="1">FGAR-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purL</name>
        <name type="ordered locus">MXAN_2349</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF92728" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92728.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D9V4"/>
    <dbReference type="SMR" id="Q1D9V4"/>
    <dbReference type="STRING" id="246197.MXAN_2349"/>
    <dbReference type="MEROPS" id="C56.972"/>
    <dbReference type="EnsemblBacteria" id="ABF92728">
        <property type="protein sequence ID" value="ABF92728"/>
        <property type="gene ID" value="MXAN_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2349"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_7"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264581" description="Phosphoribosylformylglycinamidine synthase">
        <location>
            <begin position="1"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="1139"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="1264"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="1266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="720"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1299" mass="139228" checksum="F9410F740D48DF96" modified="2006-12-12" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V5</accession>
    <name>Q1D9V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552423.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2348"/>
    <dbReference type="EnsemblBacteria" id="ABF92140">
        <property type="protein sequence ID" value="ABF92140"/>
        <property type="gene ID" value="MXAN_2348"/>
    </dbReference>
    <dbReference type="GeneID" id="41359732"/>
    <dbReference type="KEGG" id="mxa:MXAN_2348"/>
    <dbReference type="eggNOG" id="COG3687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051636_0_1_7"/>
    <dbReference type="OMA" id="IRFENML"/>
    <dbReference type="OrthoDB" id="1601417at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="284" mass="32542" checksum="E830E7D0EA3D1AFB" modified="2006-07-11" version="1">MVSPHDPGRIRPRPHLQFPFDASFPRIWHRNGPGTTHLWNGLNMLFPQGERFFVRSVNHYMPQLADTPALHAQVKAFFAQEGKHAREHQDYIELLESQGYDIRRFMRRYESFLWGVIDAKFPPSLRLSITAALEHYTALMGENTLTLGVFADGHPAMRNLIEWHAAEEIEHKAVAFDVLRKVAPGYGLRVLGMVLGVLSLFALWFAATVTLLRQERGLGWTGLLRELWRAHRKDPVLFQVLGRGLRQYLRPSFHPLDNDNLELARAHLATLEAPPPEVPEREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA20</accession>
    <name>Q1DA20_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552358.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2282"/>
    <dbReference type="EnsemblBacteria" id="ABF88067">
        <property type="protein sequence ID" value="ABF88067"/>
        <property type="gene ID" value="MXAN_2282"/>
    </dbReference>
    <dbReference type="GeneID" id="41359669"/>
    <dbReference type="KEGG" id="mxa:MXAN_2282"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_7"/>
    <dbReference type="OMA" id="RDLMFAR"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="35865" checksum="8B3B312F5619BFD6" modified="2006-07-11" version="1">MKAYELKQTGSADAWVQVERPEPTPGHGQALVRIRAVSLNYRDLYIALGRYPGPRPASLIPVSDGAGEVVAVGPGVSRVTPGDRVAPTFFQTWTDGPASPEKTRNALGGSVNGVLAEYVVVDAEGLVLLPDHLSFEEGATLPCAAVTAWNALVAEGRLQPGQTVLAQGTGGVSIFALQLAKALGARVLITSSQDAKLKHARTLGADGTINYKTHPDWEEQVLALTGGQGVDHVLEVAGEETFPHSVRATKPGGHISLIGMLSGGFAKPDPALVEPKKLDVQRTYVGSRAMFEDMNRLLIQHRLEPVIDRSFPFEQAREALRYMESGAHFGKIVIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAD3</accession>
    <name>Q1DAD3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2167"/>
    <dbReference type="EnsemblBacteria" id="ABF90214">
        <property type="protein sequence ID" value="ABF90214"/>
        <property type="gene ID" value="MXAN_2167"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2167"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641898_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="161" mass="17185" checksum="EE78DA26534243E3" modified="2006-07-11" version="1">MKRRDPASDLGSCGLPNPPAPGQPEKGLQLCASWFAPAMPLGGRPRVFSSLARLALPLVLLVGLTAVAQPQEALRGLEMKRRRVVLSEATSGKPVNTLLTVARARGCYFSEAFTLYMGAEVAATLAYAHQRTDDAGISLGIVTRDVNCVYRTMVSTDSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR2</accession>
    <name>Q1DAR2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltrans_SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552116.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2032"/>
    <dbReference type="EnsemblBacteria" id="ABF87593">
        <property type="protein sequence ID" value="ABF87593"/>
        <property type="gene ID" value="MXAN_2032"/>
    </dbReference>
    <dbReference type="GeneID" id="41359442"/>
    <dbReference type="KEGG" id="mxa:MXAN_2032"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_1_1_7"/>
    <dbReference type="OMA" id="LMKWAKR"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="38387" checksum="45B05E093BF12C7B" modified="2006-07-11" version="1">MRGAAVVWTEGRLGMADTQGTHGSHDATGPEGMFANRLRKGDKRFRKWARTQGLTAFRVYDRDIPEYPYAIDVYGDRVHVVEYPRRRAIASGAADTQREEVLAAVTQVLAVPSERVFVKTHTPQPWGRSQYGRVGQDSGRIVVEEQGLKFWVNLGDYLDTGLFMDHRNTRARVREEARGKRFLNLFAYTGAFTVYAAAGGAASTMTVDLSNTYLDWAEDNLDLNGLADARHTLVRADAKAWVEAQADAPERYDLVVCDPPSFSTSKKMSGSFNVQRDHPRLLAAIRALLAPGGVLYFSTNFLGFQLEPKATRGMEVEEITPRSIPEDFQRKEIHRCWRMVAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT1</accession>
    <name>TIG_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">MXAN_2013</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552097.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAT1"/>
    <dbReference type="SMR" id="Q1DAT1"/>
    <dbReference type="STRING" id="246197.MXAN_2013"/>
    <dbReference type="EnsemblBacteria" id="ABF92960">
        <property type="protein sequence ID" value="ABF92960"/>
        <property type="gene ID" value="MXAN_2013"/>
    </dbReference>
    <dbReference type="GeneID" id="41359423"/>
    <dbReference type="KEGG" id="mxa:MXAN_2013"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_2_7"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000256579" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="425" mass="48091" checksum="07485D58A7FE764B" modified="2006-07-11" version="1">MKVQVEELSPIEKKLSIEVDNARVAEELSRAYSNLGRQVRLPGFRQGKVPRRILEQRFRDQVEDEVIQRVVQSAYVEAIREHNVEVVATPQVTNSGLKPNTPFTFEARVEVKPKVEAKDYVELPLTKSDTAVTDEQVNEQLERMRQSMARLEPVTDRDTAASGDYVTVDFDATVDGQPFAGSKAEGITVQVQPGELVESKIAALEGVKVGESKDIDYAFPQEYRVEEVRGKTARFHITLKGVQKEIVPELNDDFAKQSGVAQSIDELRTKLREDMEKARKSQVEGEEREALMKALLERNTFDVPRAMVERAMDSMLRGALQQLQRSGVDPRQLNLDFNRLREDMREKALQEVKGTLLFESIAQKEGIQASDADVDARIEQLANEAGQPVAVVQKYFKGADERLGLSLRLREEKTIEFLRSRAKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB70</accession>
    <name>Q1DB70_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551959.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1857"/>
    <dbReference type="EnsemblBacteria" id="ABF87271">
        <property type="protein sequence ID" value="ABF87271"/>
        <property type="gene ID" value="MXAN_1857"/>
    </dbReference>
    <dbReference type="GeneID" id="41359273"/>
    <dbReference type="KEGG" id="mxa:MXAN_1857"/>
    <dbReference type="HOGENOM" id="CLU_1325186_0_0_7"/>
    <dbReference type="OMA" id="CNLELHY"/>
    <dbReference type="OrthoDB" id="1249103at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="24072" checksum="6F4552F91CF064DC" modified="2006-07-11" version="1">MKGYLQSLPGVGGLFQRDIQPAEVWAFWKYMQERLRTKTANKADSLEMQLAAEALQRMGILDRQRFLEKYATTVGRTLYVPFEVGVPKGGWDLWAQVVVCVHEHQHVVQHDEEGPSYELAYLTSSAARARYEAEAYTCNLELHYWRYGTLPAVRPMAEGLKHYGCQPEDVEVAAHTLALTSVSVRHGAVVSEATHVALEWLNSHVPHLRAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB76</accession>
    <name>Q1DB76_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical phage tail region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551953.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1851"/>
    <dbReference type="EnsemblBacteria" id="ABF87809">
        <property type="protein sequence ID" value="ABF87809"/>
        <property type="gene ID" value="MXAN_1851"/>
    </dbReference>
    <dbReference type="GeneID" id="41359268"/>
    <dbReference type="KEGG" id="mxa:MXAN_1851"/>
    <dbReference type="eggNOG" id="ENOG502Z9BU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_2_0_7"/>
    <dbReference type="OMA" id="VANVQYF"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="17331" checksum="0AA7CC2FE40BBB26" modified="2006-07-11" version="1">MAIIGQPRSFHKRFKFLCEADGLGHSGFQKCSELSVEVANVQYFEGGSLIPNKSPGRLTFSDVTLERGATQDHQLFDWFQDVVHTTSGLGLPDSLYKRNLDIVQQDRDGTTLRRWSLSRAWPVKFVAGEWDNESDENVIESVTLTYDSFELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB77</accession>
    <name>Q1DB77_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551952.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1850"/>
    <dbReference type="EnsemblBacteria" id="ABF88396">
        <property type="protein sequence ID" value="ABF88396"/>
        <property type="gene ID" value="MXAN_1850"/>
    </dbReference>
    <dbReference type="GeneID" id="41359267"/>
    <dbReference type="KEGG" id="mxa:MXAN_1850"/>
    <dbReference type="eggNOG" id="ENOG502ZB1B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081083_0_0_7"/>
    <dbReference type="OMA" id="RARIDWE"/>
    <dbReference type="OrthoDB" id="1226510at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="29039" checksum="D437D7650236939E" modified="2006-07-11" version="1">MADIISCPSGLTGRIRGMRVREERVLADRKLAKSGGQVDELLSACWEEMQEAGPYAFADGKVDWGQVLQGDRFYALLQVRVLTYGPEYAFAVPCQSAACRARIDWELDLTQLPVRVLSDASRASFVAGNRFETTLPDAGTRVRFKLLTGEDERRLPQLQRAAPEKLLSSVLAYRILDVDGVDARDKRRFLEDLSLRDADFLVDEFDAVDCGVDTTLEVECAQCFMRQEVELPFDRGFFLPGTQRTARRRERTTSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB97</accession>
    <name>Q1DB97_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89137">
        <property type="protein sequence ID" value="ABF89137"/>
        <property type="gene ID" value="MXAN_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1830"/>
    <dbReference type="HOGENOM" id="CLU_2826620_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="66" mass="7099" checksum="1A14789ABBCBBE9D" modified="2006-07-11" version="1">MDSSFFVFGAVVRGMVVFSFPGRGYTSAIHKGGPAALMRWCPAGRGVGGERRRYLLRGLLAALRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG7</accession>
    <name>Q1DBG7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551865.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1756"/>
    <dbReference type="EnsemblBacteria" id="ABF88271">
        <property type="protein sequence ID" value="ABF88271"/>
        <property type="gene ID" value="MXAN_1756"/>
    </dbReference>
    <dbReference type="GeneID" id="41359185"/>
    <dbReference type="KEGG" id="mxa:MXAN_1756"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_7"/>
    <dbReference type="OMA" id="DAAKPHG"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="34"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="38819" checksum="F08BD28374AB385E" modified="2006-07-11" version="1">MRASTTSAPASSAQSANQAYTLRSRKLGHLVVSELGFGCMSNSPGHYGPGVDRPQSIRVIRDAYDRGIRFFDTAEVYGPYVNEELVAEALGPVRNHVVIATKFGFKIDGTNGLDSRPERIRRVVEESLKRLKTDRIDLYYQHRVDLTVPIEDVAGTVKDLIQQGKVLHFGLSEPSARTIRRAHAVQPLAAIQTEYSLMERSVEDNGVLQACEELGIGFVPWGPLGQGFLPGKLPLDAQARFDAKTDLRKTFPRFSREVMQANQSILDFLKAFGEKKGATRAQIALAWLAAQKPWIVPIPGTTNLDHSRENLSSLNVNLTPEDLREIEAAFANITVHGGRMDAKQMDQIGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBN0</accession>
    <name>Q1DBN0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1691"/>
    <dbReference type="ESTHER" id="myxxd-q1dbn0">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89149">
        <property type="protein sequence ID" value="ABF89149"/>
        <property type="gene ID" value="MXAN_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1691"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_7"/>
    <dbReference type="OMA" id="GHEPWSE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="44"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="38022" checksum="18370A68615D1BD8" modified="2006-07-11" version="1">MEKLLAARGETLEVPPGQRADAPSWQVSPDVRLHHVAVGDGRDVVVVHGGPGLPPAKPWRAAAMTGDSLRWHFFDQRGCGASSRPFTHAPPGGTWQTLQTVEARLGLAAQLADLERIRRLLGKERLTLVGHSFGALVAALYAAEWPERVEALVLVAPAPLVTMPAGDGDLFTQVRARLDEAGQRELAAWMKHTFDFPARLKDDEARLAEHFAAFGPLYVQAMRREHPDAKLPGSGAAGGFLSLGLYLSLGRHHDWSDWLRRVRARTLVIHGAQDLQPRSATARVVEALPHARLVELAGSGHFPFEEQPELFAATVRAFLSEELPGPDSSPTSMRRSAPHPSPCARRTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBN5</accession>
    <name>Q1DBN5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551797.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1686"/>
    <dbReference type="EnsemblBacteria" id="ABF86201">
        <property type="protein sequence ID" value="ABF86201"/>
        <property type="gene ID" value="MXAN_1686"/>
    </dbReference>
    <dbReference type="GeneID" id="41359124"/>
    <dbReference type="KEGG" id="mxa:MXAN_1686"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056890_1_1_7"/>
    <dbReference type="OMA" id="MWLDEAN"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="32806" checksum="F8A54984F83781FF" modified="2006-07-11" version="1">MFCLRPYRDVADLNTMARLVAQAWAERGPHVECAMGDLTWRLLRNAQVRPREDIALWERAPGQLAGFAWAYNNGDVDLFVHPLVHADAFAEDVRPWVRARHERTTQPTTVWALESNGPLLAALQRRGWRRTTGGCYLHLAQPLPAVPSPPSSLPAGYRVRAVRGPEEVAARALVHRRGFGSERVTTEVYARLMEAPGYQPALDLVAEAPDGSLAACALGWLDEANAVGEFEPVACAPENRRRGLVRALLHEGLRRMHTLGAKQAIVYAFADNPASLALYQSAGFTVVDRNLGHTLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ0</accession>
    <name>Q1DBQ0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">MXAN_1671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551782.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88961">
        <property type="protein sequence ID" value="ABF88961"/>
        <property type="gene ID" value="MXAN_1671"/>
    </dbReference>
    <dbReference type="GeneID" id="41359110"/>
    <dbReference type="KEGG" id="mxa:MXAN_1671"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_7"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="692" mass="69714" checksum="33CABC325B131D51" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC45</accession>
    <name>Q1DC45_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1526"/>
    <dbReference type="EnsemblBacteria" id="ABF90488">
        <property type="protein sequence ID" value="ABF90488"/>
        <property type="gene ID" value="MXAN_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1526"/>
    <dbReference type="HOGENOM" id="CLU_3009544_0_0_7"/>
    <dbReference type="OMA" id="WGHRSEP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="56" mass="5930" checksum="3EADB9C186C89DFA" modified="2006-07-11" version="1">MAASASEAGPSFLARLVLVLLGCAFLGAAWVWSHRAEPWAARLVDNALRTVGVPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC63</accession>
    <name>Q1DC63_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1508"/>
    <dbReference type="EnsemblBacteria" id="ABF86172">
        <property type="protein sequence ID" value="ABF86172"/>
        <property type="gene ID" value="MXAN_1508"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_1508"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462958_0_0_7"/>
    <dbReference type="OMA" id="AEICEWI"/>
    <dbReference type="OrthoDB" id="133307at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="396"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="589" mass="64886" checksum="1ADEA19536872771" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ1</accession>
    <name>Q1DCJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1375"/>
    <dbReference type="ESTHER" id="myxxd-q1dcj1">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91144">
        <property type="protein sequence ID" value="ABF91144"/>
        <property type="gene ID" value="MXAN_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1375"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_7"/>
    <dbReference type="OMA" id="EGGGHYL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="164"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="29164" checksum="8FCDCD3AAD4CBA02" modified="2006-07-11" version="1">MIDGGAMPIAELNGQGIYFEDSGGNGRPIILGHGFLMDHRMFDAQVAALAPEFRVIRWDARGFGQTRWDGKPFTPWDSAADCVALLDHLGIERAVVGGMSQGGYSALRVALKHPERVRALVLLSTRGTNDDAPTRAAYQQSADIWETQGPIDPLVQGLAQAIIGDTRYFDTWLPRWRQIPGGHFANAIRSLIDRDDISGRLTEIRCPAIVFHGLEDHGMPPVHGEHLHQTLPGSVRFVPVPGAAHAANMTHPEAVNPALLEFLRAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCR3</accession>
    <name>Q1DCR3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4150 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551420.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1303"/>
    <dbReference type="EnsemblBacteria" id="ABF86728">
        <property type="protein sequence ID" value="ABF86728"/>
        <property type="gene ID" value="MXAN_1303"/>
    </dbReference>
    <dbReference type="GeneID" id="41358750"/>
    <dbReference type="KEGG" id="mxa:MXAN_1303"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130931_0_0_7"/>
    <dbReference type="OMA" id="VGVNKMS"/>
    <dbReference type="OrthoDB" id="2045896at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025425">
        <property type="entry name" value="Tox_PAAR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13665">
        <property type="entry name" value="DUF4150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4150" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="15833" checksum="B9EB4FFE248A497E" modified="2006-07-11" version="1">MANTVGVNKMSVVTKDSNGVSVAFPDVCKTPSPAGPIPLPYPNVARSADTAQGSKTVAVEGNPLCVKDSNFSTSTGDEAGTAGGGVVSGKTQGKAEFVNFSFDVQVEGKNVARALDLMLHNDKNTPPFPLMQPPVMAAGQGSGKCNCLVCEKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT9</accession>
    <name>Q1DCT9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551394.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1277"/>
    <dbReference type="EnsemblBacteria" id="ABF89315">
        <property type="protein sequence ID" value="ABF89315"/>
        <property type="gene ID" value="MXAN_1277"/>
    </dbReference>
    <dbReference type="GeneID" id="41358723"/>
    <dbReference type="KEGG" id="mxa:MXAN_1277"/>
    <dbReference type="eggNOG" id="ENOG503385A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569737_0_0_7"/>
    <dbReference type="OMA" id="TDHEDRT"/>
    <dbReference type="OrthoDB" id="878103at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188388" evidence="2">
        <location>
            <begin position="22"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="474" mass="53521" checksum="70513E3E6126C5CA" modified="2006-07-11" version="1">MTMARLLLVSLLVLCACTTLRGRADSLAQKGMFVEAAAIYDDLIRQSPYDQELLLAREGLRSRALAQLLSNAREARLEGDDEEAEAWLLRFLNHRTAWNAKLNGGLESSLHEEVDGTRRHLQRLVGNPARQGHALTAEQALRRKQPLLAHRELALISRDMEWLVLQSGKTSCQRLRDTSTDDSPHWRELVFRYCGHWREYAPRPATAPELFGPPSWTGTVEGLDEAQQAQLEARLTQAFESSPWFAPGGSARPVFSLEGRFVTQRDSHPVELTAPWTESVPYTDHEDRTETIEEPYEAEEEYTDSKGKTKTRKVTKYTKHTHTYSVPVTRYRDVPRKFEYHALRLSQAHHVTVASSVVLDARRGPFTVTLQDQLSESGHEHDVTFKEGNVRPQRPNFTLAEAWLEAKVEALRVAFSRRLAEHWRESYCSTPSLTLDEAARCARAGIAVPIQASRVLSDILGADATQVPALFALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD11</accession>
    <name>Q1DD11_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">POLAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551322.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1203"/>
    <dbReference type="EnsemblBacteria" id="ABF86326">
        <property type="protein sequence ID" value="ABF86326"/>
        <property type="gene ID" value="MXAN_1203"/>
    </dbReference>
    <dbReference type="GeneID" id="41358653"/>
    <dbReference type="KEGG" id="mxa:MXAN_1203"/>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026629_0_0_7"/>
    <dbReference type="OMA" id="VYNARAK"/>
    <dbReference type="OrthoDB" id="126790at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="3">
        <location>
            <begin position="357"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="669" mass="73393" checksum="344D416D607D9079" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD23</accession>
    <name>Q1DD23_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502ZAJW">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="402" mass="43799" checksum="1EAAB27AA3076B31" modified="2006-07-11" version="1">MWARCRVPGAETLVGFMAPMPRLLAPSQGWLFSPGVDLSVFAGSALVSVAFVLAAPWLGVADGTPLWAWLLFVVCVDVAHVWSTLFRTYLDPDELRTRPGLYLGAPLAAYMAGVVAHLVSPGTFWTLFAYVALSHFVRQQYGWVALYGRKARVSVLERRLDAAAVYAATLGPVVWWHANLPRGFWWFVPGDFLSGLPSWVGTVGLGLHAGVLFAWAGFQVARVVRGEGVQAGKVLLVVATWVAWFGGIVVARDDFTFTVMNVVLHGVPYFALLFRYARGRLDEGGYGAGAALLRAGLPGFLLFLVALALAEEFLWDQVVWREHGALFGESDMTLPPDVLSLVVPLLALPQATHYVLDAFVWKPGRQPALLSRLGWTPMATRHEGPTSGMKPVSTMAIPARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD26</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">MXAN_1188</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1188"/>
    <dbReference type="EnsemblBacteria" id="ABF87814">
        <property type="protein sequence ID" value="ABF87814"/>
        <property type="gene ID" value="MXAN_1188"/>
    </dbReference>
    <dbReference type="GeneID" id="41358638"/>
    <dbReference type="KEGG" id="mxa:MXAN_1188"/>
    <dbReference type="eggNOG" id="COG4775">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355914_0_0_7"/>
    <dbReference type="OMA" id="DVAWRTD"/>
    <dbReference type="OrthoDB" id="327324at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188159" evidence="2">
        <location>
            <begin position="23"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="815" mass="90197" checksum="9A346C31E859C816" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE7</accession>
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        <submittedName>
            <fullName evidence="2">PTS system, IIA component</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1066"/>
    <dbReference type="EnsemblBacteria" id="ABF90808">
        <property type="protein sequence ID" value="ABF90808"/>
        <property type="gene ID" value="MXAN_1066"/>
    </dbReference>
    <dbReference type="GeneID" id="41358518"/>
    <dbReference type="KEGG" id="mxa:MXAN_1066"/>
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    <dbReference type="OMA" id="GIDYNSM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16483" checksum="32D9CC838213D866" modified="2006-07-11" version="1">MRIAEFLSPQAVIADMQSRTKPEVLRELSATLVRAHPLLTADRLVEVLREREKLGSTGIGEGVAIPHGKLPGMGQLQAAFGVSHAGVDFEAIDGKPTHLFFALVAPENSAGVHLKALARISRLFKNPRFRAAILEAPTAADIHALIVQEDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDI8</accession>
    <name>Q1DDI8_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1024"/>
    <dbReference type="EnsemblBacteria" id="ABF92900">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2863104_0_0_7"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="64" mass="6958" checksum="9CFB0313FB829ABF" modified="2006-07-11" version="1">MDGGHPGDRGRMDNPAGTRHARRGPQACGCRSAECRQAVESLWRRQGDVTWMEPVSTRPAAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL4</accession>
    <name>Q1DEL4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TspO/MBR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0641"/>
    <dbReference type="EnsemblBacteria" id="ABF87387">
        <property type="protein sequence ID" value="ABF87387"/>
        <property type="gene ID" value="MXAN_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0641"/>
    <dbReference type="eggNOG" id="COG3476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091805_2_1_7"/>
    <dbReference type="OMA" id="GLNLIWM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20964" checksum="33716269966BFD88" modified="2006-07-11" version="1">MLRQGRTRMDWTLEPTTRNMPDPVRRTALNPTLRKESVVALGVFGALTLGAAALGARVSSADTRWYRRLHKPSFQPPPKVFGPVWTVLYGLIALSGWRVWTAPAGAARSQALAWWGIQMGCNAAWSWLFFGRHQPRRALADNLALLASVTAYVAVTKDVDRPAAWMVVPYLGWVGFANVLNAEIVRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEM3</accession>
    <name>Q1DEM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0632"/>
    <dbReference type="EnsemblBacteria" id="ABF91529">
        <property type="protein sequence ID" value="ABF91529"/>
        <property type="gene ID" value="MXAN_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0632"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930090_0_0_7"/>
    <dbReference type="OMA" id="FWNYAVL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="36245" checksum="BBD36259B47D9052" modified="2006-07-11" version="1">MARGVKQPLLGGRTECFMTPARPPPPSADLPQLAVHALWWGWFPAFILSWDALPWVGRLAMCLLGWAICFWNYAVLHNHMHVSIARPPLAHWVVSRSLGMACGFPYRGYFIHHFNHHRYDDGPGDWGRRRPGERVFRYCLRSALTPWLWPYETLGQVWQWAKKKNQRLELAVDFLVVDGALLALIVWKPALGLALWGVLLVTQFCIHWLNLAAHFETDSEQKDALGTTSYSAFYNRWFFNAGYHQAHHLKPQVPWYELPALTEELARTSRLRPELTTGLSPINPLWVARVVKRYSAKPCDRQTESKITAGTPTAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFE5</accession>
    <name>Q1DFE5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pilus biogenesis protein, TadE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0354"/>
    <dbReference type="EnsemblBacteria" id="ABF89735">
        <property type="protein sequence ID" value="ABF89735"/>
        <property type="gene ID" value="MXAN_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0354"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090593_0_0_7"/>
    <dbReference type="OMA" id="CERMTHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="34758" checksum="160B93ACCD4A2A34" modified="2006-07-11" version="1">MDAVTRLFHARKARLSQSRVLLFAMQGTPRQVDVCPIWTEFPEHAPAMNSMRPSGRRESGQAMVESALTLPLMVFLILGTLQLFLMLQGRLLAEYAAFRATRVGSVNHGDCQAMTHAAILALMPSYYSFLGGAGGSPGQKLANAFAARRDNQYNGATGRANRVSMPDGNHTGAIVWIIRDSPLATAVPNEDALFDQFDNPAGIVRLETRLVYWFPLKIPFANWVIARLTMARWGWRDYTNQNPLMQTQRARWTQGPPSMGLEGLIREEALRRMNSEQYVIPIHASASLRMLTPVQRRFFQTQNCAPAPEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG2</accession>
    <name>Q1DFG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protozoan/cyanobacterial globin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0337"/>
    <dbReference type="EnsemblBacteria" id="ABF90973">
        <property type="protein sequence ID" value="ABF90973"/>
        <property type="gene ID" value="MXAN_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0337"/>
    <dbReference type="eggNOG" id="COG2346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103526_3_0_7"/>
    <dbReference type="OMA" id="IGNAERD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015671">
        <property type="term" value="P:oxygen transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="15050" checksum="EFCB29788F81D33C" modified="2006-07-11" version="1">MPSPDDLPYHRLGGTDAAMALAEAFYDAMDAHEPELARLHELDAEGRVNRGTRERFGLFLAGWLGGPQDYTERHGHPRLRMRHGHLSIGVAMRDAWVRSMQRAMDARGISGGLRRFLDARFAHVADFLRNVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN9</accession>
    <name>Q1DFN9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0253"/>
    <dbReference type="EnsemblBacteria" id="ABF87951">
        <property type="protein sequence ID" value="ABF87951"/>
        <property type="gene ID" value="MXAN_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0253"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OMA" id="EDDACEG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188260" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="24506" checksum="FC0E4174BEF42329" modified="2006-07-11" version="1">MGSKRALVAWLLALVFTGCGHTAQKSQHAWEQVPHGEGESCTRVDRCVTWVCAGATQCGLYVCEDAGRLLAKGGGTIAPPAAPGAGPHRRWGNVQKLPGGNGPVFVFDWHNAPQSEHRAPRLPSGPDWVRHHLFPQAEHLAKWFARSPRALNVHDFTLVIARDTHQRIHSGTRGGAWNQEWTDFARRYPGASQQQVWEHLGKLVQKYDLIGPIVPYYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR0</accession>
    <name>Q1DFR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550377.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0231"/>
    <dbReference type="EnsemblBacteria" id="ABF90993">
        <property type="protein sequence ID" value="ABF90993"/>
        <property type="gene ID" value="MXAN_0231"/>
    </dbReference>
    <dbReference type="GeneID" id="41357731"/>
    <dbReference type="KEGG" id="mxa:MXAN_0231"/>
    <dbReference type="HOGENOM" id="CLU_1184013_0_0_7"/>
    <dbReference type="OMA" id="FWAARYG"/>
    <dbReference type="OrthoDB" id="1223377at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="26244" checksum="52B7D9DC2B4A6DCF" modified="2006-07-11" version="1">MESVSKSVEARADRLATASQEALYQDPFWAARYGLERAQRFGDEDARFHVRYLVQSLDEHLPSVLEGYARWLRTLLVSRGMCSRHLDRHFAALAAALEAEGWGPGSEPHDYVGAARQALRYQEGPARLLEEEAPELARAATARLTLYIIPEDQPRLEEELQLQLSYVADALAAGKPDLLGDHVRWYAGFWPRRGFGLLAFPSVLGMLKSVLGSRHPEARTLLSEAGVSWEETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR8</accession>
    <name>Q1DFR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550369.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0223"/>
    <dbReference type="EnsemblBacteria" id="ABF92086">
        <property type="protein sequence ID" value="ABF92086"/>
        <property type="gene ID" value="MXAN_0223"/>
    </dbReference>
    <dbReference type="GeneID" id="41357724"/>
    <dbReference type="KEGG" id="mxa:MXAN_0223"/>
    <dbReference type="HOGENOM" id="CLU_1169664_0_0_7"/>
    <dbReference type="OMA" id="LTWARIT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23145" checksum="8E0B7AE0CE289A22" modified="2006-07-11" version="1">MCVTPGTQKVVTNMLAHHNTQLVALSPAPSTLAEGATPPWPPPPLRVQPKPPAHYQGTTNTIIIGIGLPLLGAYALYENERAVAMVGFIGGLVAWIFAALRFSQEGKARQHNQAEHAEHVRRAILTWARITDSAIVEQVPDSDGRSTHYLLDLHVTPWHPSHPAPRKVPLRLRVPVAHGPHVVPGAYLGVLSDPEAAWVVPQSLLTLQGAQLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG77</accession>
    <name>Q1DG77_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550212.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0063"/>
    <dbReference type="EnsemblBacteria" id="ABF89589">
        <property type="protein sequence ID" value="ABF89589"/>
        <property type="gene ID" value="MXAN_0063"/>
    </dbReference>
    <dbReference type="GeneID" id="41357572"/>
    <dbReference type="KEGG" id="mxa:MXAN_0063"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852129_0_0_7"/>
    <dbReference type="OMA" id="HTSIDMR"/>
    <dbReference type="OrthoDB" id="1495965at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="216"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="34668" checksum="6F8C49CA5E5ADB62" modified="2006-07-11" version="1">MGPSGGRYSGRPWSLSPMSSPSPAARMPPAASREAELARAESELSTLEGRLHEQLAQATAEASALATRLEQTRQALTRAHQAPGADPMLGEQASRLQLAVAPALDVEAPRIRALEARQAALLARRQAGSEMQSLLRAHQEQAAQVARAVTEAEAVLKRQAEAAKARQEAASRAQHEAAKARQAELARAAAAARAQGHAPLPAAAARPATPPENDARRNGRVRMHTSIDMRSDSNFFTGFSLDLSEGGVFIATVDAVPRGTQVELDFTLPGGRPMKVTGVVRWVREANSRTPELMPGVGVQFTGLPAEVASAISSFITTRDPMFFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA9</accession>
    <name>Q1DGA9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550180.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0031"/>
    <dbReference type="EnsemblBacteria" id="ABF88733">
        <property type="protein sequence ID" value="ABF88733"/>
        <property type="gene ID" value="MXAN_0031"/>
    </dbReference>
    <dbReference type="GeneID" id="41357540"/>
    <dbReference type="KEGG" id="mxa:MXAN_0031"/>
    <dbReference type="HOGENOM" id="CLU_1617229_0_0_7"/>
    <dbReference type="OMA" id="RMRFSHG"/>
    <dbReference type="OrthoDB" id="1997613at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188599" evidence="2">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20564" checksum="A498C99C1EDC94F9" modified="2006-07-11" version="1">MLDTKNVMRITCLVLLGALGGCTQASSGDATSTVRWGNGGRWAAGAMTDAVVGAPVGATVSAVVGTTTLAAGAYCEASPAACSEVPRSVLSLSPTMLPGARWMLAAEHTKGKRSSTWDKHTKTRSGGKEKKDDRMRFSHGADDSNKEKKEEAKRKKEEEKRQKEEARLKKEEERIKREEDRRKKESAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGC5</accession>
    <name>Q1DGC5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HipA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550164.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0015"/>
    <dbReference type="EnsemblBacteria" id="ABF92663">
        <property type="protein sequence ID" value="ABF92663"/>
        <property type="gene ID" value="MXAN_0015"/>
    </dbReference>
    <dbReference type="GeneID" id="41357522"/>
    <dbReference type="KEGG" id="mxa:MXAN_0015"/>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050829_0_0_7"/>
    <dbReference type="OMA" id="MRPQGYL"/>
    <dbReference type="OrthoDB" id="1293681at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HipA_C" evidence="2">
        <location>
            <begin position="200"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="436" mass="48297" checksum="6D7C759554C0D290" modified="2006-07-11" version="1">MATLEQLLAVLGRQVEVKGSELATQLRVSRPTVSRLLASAGPSVCRMGQGPATRYARTRSIAPLGEQVRMYRVDETGRPHEAGVLHPLWNGGCWIAREDGVGERFAGLPPFAADMSPQGYLGRGFTSRHLELGLPPRITDWTEDHQLIALALRGDDCVGNHIIGAASLDRFLASPLRPVTEAQYPELARSSMSSEAGSFAGGDQPKFTAYAERRHVLVKFAANDDGAAAQRWRELLVCEGLALEVVRNAGIPAAASRSIRVEGYQFLEVERFDRVGERGRKALLSLKAIDNEYLGHEGKGSTWTSAARYLLQSQYISEEDVRRIRWLDTFGQLTGNTDRHFGNLSFFEDGPKRFRLAPAYDMLPMMFAPVGTSIIDRTFEPRPPTSETLDVWADAAQHALAYWSRLEQTPELSDTFRGHCARCRDSLAALMQRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH4</accession>
    <name>Q1CVH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557398.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7496"/>
    <dbReference type="ESTHER" id="myxxd-q1cvh4">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90481">
        <property type="protein sequence ID" value="ABF90481"/>
        <property type="gene ID" value="MXAN_7496"/>
    </dbReference>
    <dbReference type="GeneID" id="41364629"/>
    <dbReference type="KEGG" id="mxa:MXAN_7496"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_7"/>
    <dbReference type="OMA" id="HTHESVM"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="28486" checksum="48C0CECC0E4A3840" modified="2006-07-11" version="1">MTSTSRTVQGPTGQLAVTDTGNGGLPIVFVHSNASRREQWAAQQAHLKQRSVSFDLRGMGDSGLDAQGRYGAEDMANDIHAVATALDLERFVLVGHSFGGYVAAEYARGWPERLAGLVIVDAAGTMPPLPPEQLQGFHEGTRPESYRAFMDAWFTPILQNAKPHTHESVMRWLHATPREVVVGALESMLTFNSDRVLERYKGPLHTLVVDAFIQPNAYHLLYPGTPHTVFSGVSHWLMMDAPERFNAALDAFLATLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVK1</accession>
    <name>Q1CVK1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557375.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87510">
        <property type="protein sequence ID" value="ABF87510"/>
        <property type="gene ID" value="MXAN_7468"/>
    </dbReference>
    <dbReference type="GeneID" id="41364614"/>
    <dbReference type="KEGG" id="mxa:MXAN_7468"/>
    <dbReference type="HOGENOM" id="CLU_1545978_0_0_7"/>
    <dbReference type="OMA" id="WEFQAAV"/>
    <dbReference type="OrthoDB" id="1719690at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="18673" checksum="56CBA08D4F31543C" modified="2006-07-11" version="1">MARRRYTPWSATNGLLFGMAAGVVLALAEVVLAVASGDNPMHPVRMSAGVLLGPSAFTAAVSDSTALLLGMGVHLMISAVVGLFYSVLDAFLPPDGRSRWEFQAAVGMLYGIFVWLVNFQFIGRGSYPWFLDVPQFPQIVVHAFFLGLPLASLFTAAERRRLLLDAAESTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVP1</accession>
    <name>Q1CVP1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7426"/>
    <dbReference type="EnsemblBacteria" id="ABF86347">
        <property type="protein sequence ID" value="ABF86347"/>
        <property type="gene ID" value="MXAN_7426"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7426"/>
    <dbReference type="eggNOG" id="ENOG5033FW3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166124_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="138" mass="15780" checksum="30AD746F9015403C" modified="2006-07-11" version="1">MGVRSKGRRMLHREGRLFIWWVDAADGPEKVLHVIADDKRFHVQYPLEQPAEEGVLAVHGREFPGLPDAGSGWIRVRVPTWDSTAVGPGFVRRLIDWALTPDKPLLRVDWRGKPKEGDDAPSIDLPDIIQRPLHRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW82</accession>
    <name>Q1CW82_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557147.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7229"/>
    <dbReference type="EnsemblBacteria" id="ABF92589">
        <property type="protein sequence ID" value="ABF92589"/>
        <property type="gene ID" value="MXAN_7229"/>
    </dbReference>
    <dbReference type="GeneID" id="41364397"/>
    <dbReference type="KEGG" id="mxa:MXAN_7229"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020205_0_0_7"/>
    <dbReference type="OMA" id="SPIALFR"/>
    <dbReference type="OrthoDB" id="456222at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187701" evidence="1">
        <location>
            <begin position="24"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="744" mass="82492" checksum="AEC75B44725F903F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG4</accession>
    <name>Q1CWG4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_7146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7146"/>
    <dbReference type="EnsemblBacteria" id="ABF91651">
        <property type="protein sequence ID" value="ABF91651"/>
        <property type="gene ID" value="MXAN_7146"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7146"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="INIMGLA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="421"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="715"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="809" mass="85606" checksum="BCA3E13F77D6D5ED" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ6</accession>
    <name>Q1CWJ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7114"/>
    <dbReference type="EnsemblBacteria" id="ABF88682">
        <property type="protein sequence ID" value="ABF88682"/>
        <property type="gene ID" value="MXAN_7114"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7114"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_0_0_7"/>
    <dbReference type="OMA" id="TGIMYNT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188128" evidence="1">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="36372" checksum="E46B3525564F38B8" modified="2006-07-11" version="1">MLLRAAGVATALVLLAACRIESAAPSAGPTLAREGTPSGDVWVYTSMYRHVLDALEPLLKARLPDVRVHWYQAGSEKVASRLEAERAAGAIRADLLATSDPFLYERLAREGALLRYASPNVLRVPRALVDLDARYAALRLSTMVLVHRQGGPPPPTSFAALAEGPWTGRVAIGDPLTSGTAFTWAVFCDAKYGASFFPGLRQRGAIVAGGNAAVLQKVESGEADAGVLLLENALAAQARGSPIQVVWPTDGAVVIPGPAALFATTPNPVAAKAVVDVLLSPEGQRIIVEKGDMHAVDPRLAGPRGEAGVSELLERARPWTPELLERGLTQGGAVKERFRQAFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWP3</accession>
    <name>Q1CWP3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative NADH dehydrogenase/NAD(P)H nitroreductase MXAN_7067</fullName>
            <ecNumber evidence="5">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitroreductase family. HadB/RutE subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556986.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7067"/>
    <dbReference type="EnsemblBacteria" id="ABF88192">
        <property type="protein sequence ID" value="ABF88192"/>
        <property type="gene ID" value="MXAN_7067"/>
    </dbReference>
    <dbReference type="GeneID" id="41364242"/>
    <dbReference type="KEGG" id="mxa:MXAN_7067"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084441_0_0_7"/>
    <dbReference type="OMA" id="LMVVNIG"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01204">
        <property type="entry name" value="Oxidoreductase_RutE_HadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 5" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="22129" checksum="CE4F28633D19F3B7" modified="2006-07-11" version="1">MATQQAGLDANALNQLFLDARTHNAWLDKPVADDVLQQLYALTRMAPTAANSQPVRIVFVKSREAKERLKPTLSPGNVDKTMNAPVTAIIAYDTAFYEKFPQLFPLRDMKAGFLAMPAEAREKTAYMNSSLQGGYFILAARALGLDCGPMAGFDNAKVDAAFFPEGKWKSNFLINLGYGDAEKLFPRNPRLDFSEACRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX56</accession>
    <name>Q1CX56_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556823.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6903"/>
    <dbReference type="EnsemblBacteria" id="ABF90167">
        <property type="protein sequence ID" value="ABF90167"/>
        <property type="gene ID" value="MXAN_6903"/>
    </dbReference>
    <dbReference type="GeneID" id="41364086"/>
    <dbReference type="KEGG" id="mxa:MXAN_6903"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933265_0_0_7"/>
    <dbReference type="OMA" id="REPAFHG"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="32510" checksum="02B59053463A64DA" modified="2006-07-11" version="1">MDLFLMSPPGRTWALRGRSNFRSREAPPVDARQARREWLALARDIEARGGTVVALPSPSELLTGMPYAAECGQVVARQGAAPLFVLPRVMSAHRQAEREHWAPLARSLGMEVVDPGVGIWEAHGDVATFDGVTLLFWGGRTTLDGLEAAARYFPGEVLRIQVREPAFHGNMAVLPLPAVDRLMVCPDVMAPESHALLRERFGEHRLLLVTEAEIRRYATNGLPVGRDVLAPSVVPDSVRERLEALGLRVVSLTMRELCEKGGGSSRCLVSRAEVDAATLNIPDAFRLSAIARDIDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX68</accession>
    <name>Q1CX68_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556813.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6890"/>
    <dbReference type="EnsemblBacteria" id="ABF88784">
        <property type="protein sequence ID" value="ABF88784"/>
        <property type="gene ID" value="MXAN_6890"/>
    </dbReference>
    <dbReference type="GeneID" id="41364076"/>
    <dbReference type="KEGG" id="mxa:MXAN_6890"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705619_0_0_7"/>
    <dbReference type="OMA" id="GIFYQRP"/>
    <dbReference type="OrthoDB" id="1130828at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="36"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="41993" checksum="37EADB89B00FEFA8" modified="2006-07-11" version="1">MNKTSSIQAALARAAEAAAEAPRSVPAEDHVWRRRLVIGDPQADLDQVLAILAHHGLLTGEGWLRSDVQLISVGDHFDWGKPAERESAAASGLALVAWLAAHPATQAVMLLGNHDLARVGELAGFTDARFAEAQAEADRIYQGGATDEAAEQAFLARWPEVPSAELVARDFGNFRAVQRTWVEHLLRVKRFRVAHAAAPDLLVLHAGVTQEDLDVTRLPPAQREDANQVAAALNAALDAAVAGWTRGPLVIPGLHHPGDAAHGEGTGIFFQRPSLLPEDAERVRGTPRRRFDPRRLPTGLTQVVGHTRDKRSRAMLGMPPTGARDGVLRHLITDGTRVDYAHGAPHPPAPGTAMLVFTDGAMRECQAPDYELFDLDTRAAATAPRPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXH4</accession>
    <name>Q1CXH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6782"/>
    <dbReference type="KEGG" id="mxa:MXAN_6782"/>
    <dbReference type="eggNOG" id="ENOG50319EE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_5_0_7"/>
    <dbReference type="OMA" id="ITYCTAX"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="103" mass="10950" checksum="2E647E6DCF069FD0" modified="2008-02-26" version="2">MVVARTKLGSWGAHAVCPAHVRRMAMADPKVTITYCTAUGYRPRAARAAAALKDELDVEAELLPGPSGSYEVAVDGKVVIRKASLAFPTDHEVVDAVAKVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ0</accession>
    <name>Q1CXQ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT</name>
        <name evidence="3" type="ORF">MXAN_6706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556631.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6706"/>
    <dbReference type="EnsemblBacteria" id="ABF92131">
        <property type="protein sequence ID" value="ABF92131"/>
        <property type="gene ID" value="MXAN_6706"/>
    </dbReference>
    <dbReference type="GeneID" id="41363899"/>
    <dbReference type="KEGG" id="mxa:MXAN_6706"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="QVTHREV"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="125"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="40316" checksum="1A62D9E91CA03927" modified="2006-07-11" version="1">MTTPRLAVLFDVLLEQKGSDLHLGIGYPPMGRIRGELVPLREQPLTAAEMQALLFEICSPEQQRQIVEDLDLDFAYSYGTKARFRANYFNKMTGLAAVFRTIPSKVLSLEDLKTPEVVRKLSERRSGLVLVTGPTGSGKSTTLAAMINHINKTRPAHVLTIEDPVEFVHESMRAQVTHREVGPHASSFATAIRSAGREDPNVILIGELRTNETMKLALQLASFGVLVFATVHTNSAPATIDRIINAFPADEQQQVRGMLAESLAGIVAQQLIKTADGKGRVAALEILVGGPAIASMIREGKVFQIASKMQAGQGQGMQTLDMHLERLVKDDVITPEAALEKAQDKENLAKIISRLKPDWQVPESLKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXR1</accession>
    <name>Q1CXR1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DifB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">difB</name>
        <name evidence="2" type="ORF">MXAN_6695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556620.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CXR1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6695"/>
    <dbReference type="EnsemblBacteria" id="ABF86902">
        <property type="protein sequence ID" value="ABF86902"/>
        <property type="gene ID" value="MXAN_6695"/>
    </dbReference>
    <dbReference type="GeneID" id="41363888"/>
    <dbReference type="KEGG" id="mxa:MXAN_6695"/>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132653_0_0_7"/>
    <dbReference type="OMA" id="AQWIHES"/>
    <dbReference type="OrthoDB" id="1817663at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="24861" checksum="47DBEAA7A6E402ED" modified="2006-07-11" version="1">MSQTPSDNVDAKLKAAEDHLREVMLALPEVTEEFPWGHRTAKVKGKMFAILVLDNDGLGVTTKLPESNEAALTLPFTAPTGYGLGKSGWVSSHFKPGSEVPIGLLAQWIHESFRAVAPQKVLKALMAPGAAQAPKAKPAARKAKSAARKAKPAAKPAAPARTSAAAKPGAGAGKGGAAKRGVAAGRAVARTSAAGKKPASGKAAVGGKKSVAKPASAREGPTRRAGAKQTSTAKRGAAGSSRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY91</accession>
    <name>Q1CY91_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556440.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6509"/>
    <dbReference type="EnsemblBacteria" id="ABF86475">
        <property type="protein sequence ID" value="ABF86475"/>
        <property type="gene ID" value="MXAN_6509"/>
    </dbReference>
    <dbReference type="GeneID" id="41363717"/>
    <dbReference type="KEGG" id="mxa:MXAN_6509"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052514_0_0_7"/>
    <dbReference type="OMA" id="GIDFMRV"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188036" evidence="1">
        <location>
            <begin position="29"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="37587" checksum="21C34DC2B89797A1" modified="2006-07-11" version="1">MVRGARNEGGRLFGALSRLMAMPLHALAADALPSWNEGPVKQAIIDFVARATTKGGAGFVPPEARIATFDNDGTLWPEQPLVQGAFMLKPLRSRVKEDPSLAKRQPFKAILEGDLSELSTMDKSKLMKVLGVTHAGMTEEAFIRKVRAFFQHARHPRWSVPYNQLAYAPMLELLRYLRANGFQTWLASAGGIDFMRVISEDTYGIPPQQVIGSHLKKTFDDAHAPSVLRREARVAHVNDKAGKPVGIDEHIGRRPVFAAGNVRSGGDIQMLQYTRKRPRPGFALLIHHDDAAREFAYEEKDGASLKAAREGGWAVVSMRRDWRRIFDETRARTGNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ90</accession>
    <name>Q1CZ90_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6152"/>
    <dbReference type="EnsemblBacteria" id="ABF92685">
        <property type="protein sequence ID" value="ABF92685"/>
        <property type="gene ID" value="MXAN_6152"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6152"/>
    <dbReference type="eggNOG" id="ENOG5031DA6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798823_0_0_7"/>
    <dbReference type="OMA" id="KFERPTM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="42467" checksum="3E049CA37B3B1B2F" modified="2006-07-11" version="1">MSSPPRLEALGRRDARRSSPIGPGGHDSASGQLRPSAAMGAALEVSSGLSVPTQLRRGDRDNPYDFVHFKFERPTMGFDIRKTFNSARANVQKVAKDVQKTVEDNKGLIKGATAVATQSAKAFGYGKDAFQQIKNIKNGAEGLLTGANRAFVSNPTYAAGEFKGLTKLGAGMKAAARYAGIPGAVMSGATAVKDIRQAIRTGSKDDIITATRSSLDATKAGLSAATGGIVGGKVMGGVLGGTVFKDKLEAGKKAVDAFKKALPNASDDVLKAVKDTATKGIFEGGTAKGVGRAVKSAAAETAKATSTLAQGLTGSGTRQAAKAALKTAGKEAGEAALKQGAKAAAGTAAKALGRFAPGVNVAIAAVDVANAGATLMDKNASTGKKVTSVITAVGSVAAATNIPIVSQVGAAVSTVSSIVGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZD0</accession>
    <name>Q1CZD0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6108"/>
    <dbReference type="EnsemblBacteria" id="ABF86610">
        <property type="protein sequence ID" value="ABF86610"/>
        <property type="gene ID" value="MXAN_6108"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6108"/>
    <dbReference type="HOGENOM" id="CLU_1336315_0_0_7"/>
    <dbReference type="OMA" id="CFDARSV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="22555" checksum="28AACE329F373394" modified="2006-07-11" version="1">MRPRAEDGVQVLHVSSSLVGVTGTRRETVVGAIPSRPVTFFRGSSPGAGLGATLDTRGDWMNPRGWGVVPIRMPVLRYAFTLNAVRELGRLAPDIARARAEAALDTSLLHIREACTAALGMEFDTLMCFDARSVVRLFSHAEQARILARLVDERARTLARLGRFQEALEDTVYAGQLLACSRQRFGLPKDARAAETLEREVPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZP0</accession>
    <name>Q1CZP0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555947.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5998"/>
    <dbReference type="EnsemblBacteria" id="ABF88595">
        <property type="protein sequence ID" value="ABF88595"/>
        <property type="gene ID" value="MXAN_5998"/>
    </dbReference>
    <dbReference type="GeneID" id="41363237"/>
    <dbReference type="KEGG" id="mxa:MXAN_5998"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663475_0_0_7"/>
    <dbReference type="OMA" id="WGDDYGT"/>
    <dbReference type="OrthoDB" id="1573721at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188029" evidence="1">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="39483" checksum="23BFD70563417076" modified="2006-07-11" version="1">MNRIQRVVMTGLFAGVLGGAPASWAGAAKTQFPVVFAHGMGGFDDLLGYDYWGNDFGTFVGEACESRFDTNCNSDLDPGQRAFVAQVAAFQSSEVRGLDLADDIEGFMATTGVSKVSIIGHSQGGIDARKAARVLRERRGATSVAVLASVSSPHRGSPVAKYILDQKPGVTSVIAALARYYGDSVYAPGNDAYAAAKQLVFNDYSSSDGVVTGMKAFNEKYPVSSNYAERYVSLITAQFGGNVNPALYLLKEFLFDIDGNGYCVGDGDNDGAAGCGDGVRNEADDDGMVGINSQQMGRRLRYHDAFFGFDSVTDDASIPTLNDLNAPSRLQSTSMSSVVPQDHVDVVGVGPDAFDEPEFYAALIHYISLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D074</accession>
    <name>Q1D074_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555763.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5812"/>
    <dbReference type="EnsemblBacteria" id="ABF88531">
        <property type="protein sequence ID" value="ABF88531"/>
        <property type="gene ID" value="MXAN_5812"/>
    </dbReference>
    <dbReference type="GeneID" id="41363053"/>
    <dbReference type="KEGG" id="mxa:MXAN_5812"/>
    <dbReference type="eggNOG" id="ENOG5033BYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026103_0_0_7"/>
    <dbReference type="OMA" id="AWRADLY"/>
    <dbReference type="OrthoDB" id="1259237at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="28705" checksum="946718B684A911A9" modified="2006-07-11" version="1">MPTQEDARTVARFIHALSGGSEVRRKAAARELAWRDPLDSNELVGHLIALSRAGWGPASCALSDFMAALEQEAEHIPHVASLRRLAHVQSLDTVADLFAQGPAKLEMDPDAAARADANAFSQSLGHLKQQARLTRDPDTLSRLATVSNPTVLRNVLINPRLTEELVVRIAARRPARPEPLIEIWKSPRWSVRHAIRRALVFNPYLPPETGAKIVPLLNTADLRELVSNAALHPALRAQATRLLAEGNGTGPAAASLIPGRRGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0L4</accession>
    <name>Q1D0L4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555624.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5671"/>
    <dbReference type="EnsemblBacteria" id="ABF88941">
        <property type="protein sequence ID" value="ABF88941"/>
        <property type="gene ID" value="MXAN_5671"/>
    </dbReference>
    <dbReference type="GeneID" id="41362915"/>
    <dbReference type="KEGG" id="mxa:MXAN_5671"/>
    <dbReference type="HOGENOM" id="CLU_873839_0_0_7"/>
    <dbReference type="OMA" id="QFMGRAS"/>
    <dbReference type="OrthoDB" id="895067at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="33563" checksum="D39861D9A2BE5D88" modified="2006-07-11" version="1">MSLSIAKSILCNGFSGNTRGCGPTDRYQAAYQSMDPSKAAQTVLKHFDAIEGVGMNASGKGAGDNNIGTSELKRVADPNSGFPPDVRAAAKWMLDHPIALRSLDQGASKAHGGNNEVHLSKADLQARAGNASDSGAPHRPGFPQRPPLFGSGFGGGFGGGCGGGLGGPGGLPNPHRPNLPPRLDLCGPQSRPPFGAGRHEPMDVYKAAQTLKDHFHFAEGVGMNASGKGAGDNNIGMSELKRVADPRSGAPKELREAAQFLINHPTALRSVDQGASKSKSSKEVHISLQDLESFTAKAPRRETQSNRLDLAQFMGRASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D140</accession>
    <name>Q1D140_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5490"/>
    <dbReference type="EnsemblBacteria" id="ABF93162">
        <property type="protein sequence ID" value="ABF93162"/>
        <property type="gene ID" value="MXAN_5490"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5490"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035227_1_1_7"/>
    <dbReference type="OMA" id="IWILKLD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="43623" checksum="06156ECDEE95F8A2" modified="2006-07-11" version="1">MHQSGGPQDELAQAVTTSGDAVYTAGYTSGQLGAEPSAGGQDAYVSKYDASGALLWTRQLGTSANDRALAVSADESGNVYVAGYTWGSFSFYENAGGTDLFVAKYDAKGAFQWVRQFGTATDDYATGIAATRLASHDVVFVSGYSLGRFDGSAPQGNYDVVVAKFDTGGNPYWLRQFGSARSDVALGVAVSPNEDVYVTGYTYGSFDGVTNPGNTVDLFLAKYSVLGEPQWIRQLGSSHDEFGTGVAVADDGGVYVSGYTSGALEGSTRLGSYDAVLVKYDTQGNWHWTRQIGTATTDYAQSVAVGKEGRVYLAGFTSGAMGGEPLLGSTDMFLATYDSRGTWLDFRQVGSTSADRGQGVATAEDGSVYLVGYTLGQTSSFPSAGGYDAVLYRFLDGAALPDEPGPWGPRGDSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D182</accession>
    <name>Q1D182_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1 repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5448"/>
    <dbReference type="EnsemblBacteria" id="ABF86034">
        <property type="protein sequence ID" value="ABF86034"/>
        <property type="gene ID" value="MXAN_5448"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5448"/>
    <dbReference type="eggNOG" id="COG5184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410399_0_0_7"/>
    <dbReference type="OMA" id="GRWHTCA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="669" mass="67432" checksum="BC403A3E226E71AA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D196</accession>
    <name>Q1D196_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Development-specific protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tps</name>
        <name evidence="4" type="ORF">MXAN_5432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555392.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D196"/>
    <dbReference type="STRING" id="246197.MXAN_5432"/>
    <dbReference type="EnsemblBacteria" id="ABF88997">
        <property type="protein sequence ID" value="ABF88997"/>
        <property type="gene ID" value="MXAN_5432"/>
    </dbReference>
    <dbReference type="GeneID" id="41362693"/>
    <dbReference type="KEGG" id="mxa:MXAN_5432"/>
    <dbReference type="eggNOG" id="COG4833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530926_0_0_7"/>
    <dbReference type="OrthoDB" id="129696at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="19236" checksum="9514FE18D373F9B7" modified="2006-07-11" version="1">MANITVFYNEDFGGKQVDLKPDEYKRDKLEALGIENNTISSVKVPPGVKAILYKNDDFTGDQIEVVANAEELGPLNNNVSSIKVMSVPVQPRARFFYKEQFDGKEVDLPPGQYTQAELERYGIDNNTISSVKPEGLKVVLFKNDNFSAGDTLSVTSNAPSLGAMNNNTSSIRITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1E9</accession>
    <name>Q1D1E9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555339.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5374"/>
    <dbReference type="CAZy" id="CBM20">
        <property type="family name" value="Carbohydrate-Binding Module Family 20"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87661">
        <property type="protein sequence ID" value="ABF87661"/>
        <property type="gene ID" value="MXAN_5374"/>
    </dbReference>
    <dbReference type="GeneID" id="41362642"/>
    <dbReference type="KEGG" id="mxa:MXAN_5374"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355572_0_0_7"/>
    <dbReference type="OMA" id="WARYNDD"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187803" description="Alpha-amylase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="5">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="6">
        <location>
            <begin position="685"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="789" mass="85407" checksum="F7061EF6D7F09909" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R1</accession>
    <name>Q1D1R1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91309">
        <property type="protein sequence ID" value="ABF91309"/>
        <property type="gene ID" value="MXAN_5260"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5260"/>
    <dbReference type="HOGENOM" id="CLU_613689_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="48340" checksum="1E60973AE00A4BAA" modified="2006-07-11" version="1">MGAKALVRCPGPLAIPTIRSPYLSTQSPERSNLRPSSELRSASRSARAALLLAAVMHLATASTAFAAPSVANKSPAKVDIQTVEVKMKSITKKFERSDWKDPNTLDEIAKLLDDVETRIARIKEKDKDWDTSSFETFFSESTAKWKKASEEVNAAHGEMQLDLERRARFTTIGDRHGAAIQAGLMALDGQVRGALGHVREDMGAILALPALAKECEDRQYPTIQKYYEDEGRAKQPKVVCELAGNHQKIAETYVSLAAKARLEDQLKVDQEALTALEQDGALSNVWLARFKNPAAHAKQVASEFAELTASASVTIGADHFKPLEVQAKKFKEVLAAAVRVDRFPKVWSTNDAKLNGSVSGQVKSFGGTLVKLRTSGTTMVEKNDLGIPLAQSTRGAALVRVASDGGFCRLYDDVGFSGTYKGGGAYAPLSYSSGIEDEFKVTVCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F0</accession>
    <name>Q1D2F0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mvaD</name>
        <name evidence="5" type="ORF">MXAN_5018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.33" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5018"/>
    <dbReference type="EnsemblBacteria" id="ABF91726">
        <property type="protein sequence ID" value="ABF91726"/>
        <property type="gene ID" value="MXAN_5018"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5018"/>
    <dbReference type="eggNOG" id="COG3407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_0_0_7"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MDD_C" evidence="4">
        <location>
            <begin position="182"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="35601" checksum="D927D9C9A3208DC2" modified="2006-07-11" version="1">MSLPMKATALAHPNIALVKYWGKRDDALILPHQSSLSLTLSPLSVTTTVEFGAASDQVELNGHTAKGSERDRVLRLLELVRAQAKADLGPAKVVSRGDFPMAAGLASSAAGFAALAVAGRAAAGLPSEPRAASILARMGSGSACRSVQGGFCEWQRGERPDGEDSFAVQRFDAAHWPDVRMVVAILDRGEKEVKSRDGMKLTVDTSPYYPAWVKDAEVEVVQVREHIARRDLQALGELCERNAWRMHATSFAANPPLSYMSPGTLALILHLKEQRKKGIPVWFTLDAGPNPVLLTDAAHEVAAEALARACGALDVIRCVPGGDAELKAEHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2I8</accession>
    <name>Q1D2I8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4979"/>
    <dbReference type="EnsemblBacteria" id="ABF90555">
        <property type="protein sequence ID" value="ABF90555"/>
        <property type="gene ID" value="MXAN_4979"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_355597_0_0_7"/>
    <dbReference type="OMA" id="APAMESI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="1">
        <location>
            <begin position="68"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="1">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="1">
        <location>
            <begin position="536"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="886" mass="92459" checksum="1151392416012E63" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2V8</accession>
    <name>Q1D2V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4856"/>
    <dbReference type="EnsemblBacteria" id="ABF90726">
        <property type="protein sequence ID" value="ABF90726"/>
        <property type="gene ID" value="MXAN_4856"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4856"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608100_0_0_7"/>
    <dbReference type="OMA" id="ARTEWAH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188172" evidence="3">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="48920" checksum="73866A5D3F2D4D38" modified="2006-07-11" version="1">MHYRRRFFSLLFVFSTATACINVPEVEPLPNGPEADAGTQPDAGSEEPRTLTLLNTLPAGGSTQVPIDTQFVLTFSSPIEEDSLNVTIQPQVTLARTEWAHQGATAIVHPAAALAENTTYTVTVNAENGAGQSLTGTRSFTFTTTGPAPDTTAPTLLNTTPGQAAIGVARDTVIEVLFSEPMDKNSVQAAFAITSPAGLNSGSFSWNEAETVMTYTSPASAAYGATIAWQISTFAKDKNGNALQDLAKQEFRIVRQATMTMPLIYSASGTITAGSSVRHYRSYNTYELERIGDNGAQQGSRLFLAFKLDTLPLDTIRINRATVRWWLSLRLGNPFEKLGPLLLEPVDVGESLPQSHAEETENPVLTAAYTARPLAPGFTIAEADTGTPGQFDVTSYVTTNWSRRDEANYRSQFRIRFTSETDNDRDTDELRSSPTTHPTLADLEVIYEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D377</accession>
    <name>Q1D377_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ORF">MXAN_4734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4734"/>
    <dbReference type="EnsemblBacteria" id="ABF88223">
        <property type="protein sequence ID" value="ABF88223"/>
        <property type="gene ID" value="MXAN_4734"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4734"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3422991_0_0_7"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="5">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="373" mass="41287" checksum="CC0D5C0BE4DB1D21" modified="2006-07-11" version="1">MANDSMEKINGLRERVLALRGHLDLDRKRSRIALIERDSTLPTFWDDNTKAQALLKEKSTLEASVGAYDKVMRGLDDAQVLFELAVEANDEATTQEAEGSLTGLEGDVAKLELARMLSGEQDRSSCFMDINAGAGGTDSMDWAAMLLRMYTRYCENKGWKVEINDEVPGEEAGFKNVSLRIEGDFAYGYLKAEVGVHRLVRISPFDANARRQTAFASVDVYPEVDDTIQIDIPEKDIDLKFIRGGGAGGQKVNKTSSTAQLRHLPTGIIITCQTERSQSANKDMAFKILRGRLYELEMKKREAARDAAEAQKKDISFGSQIRSYVLAPYRMVKDLRTGIETGNVDAVLDGDLEEFVTSQLLGVKNPNRSAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D4</accession>
    <name>Q1D3D4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002636736.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4673"/>
    <dbReference type="EnsemblBacteria" id="ABF86590">
        <property type="protein sequence ID" value="ABF86590"/>
        <property type="gene ID" value="MXAN_4673"/>
    </dbReference>
    <dbReference type="GeneID" id="41361973"/>
    <dbReference type="KEGG" id="mxa:MXAN_4673"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116276_1_0_7"/>
    <dbReference type="OMA" id="MITTRAE"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="149" mass="16552" checksum="C21460DC4D43BEE8" modified="2006-07-11" version="1">MLDKNAIGRASPPTLNEVEKGAIRRFAEAIGDYNPIYYDEEYARASGYPTIIAPPTFPASFHSAADLRELLGVGIKSLLHAEQGFDYERPIFAGDRIYVSTRVSDVFERPGMSGKMDIAVIEDEGRDEEGNLVFRARRTLVVRAAKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3G0</accession>
    <name>Q1D3G0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ORF">MXAN_4647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4647"/>
    <dbReference type="EnsemblBacteria" id="ABF87551">
        <property type="protein sequence ID" value="ABF87551"/>
        <property type="gene ID" value="MXAN_4647"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4647"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_2_0_7"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="130"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="54939" checksum="4B43FF31437F0078" modified="2006-07-11" version="1">MVLSVGELTRQLKQTLESRFARVIVRGEVTGFRGPNARGHWYFSLKDAGAAIDTKVWASMAARLRFALRDGMEVIAEGSVDLYEPQGRYSLIVQRLEPVGEGALALAFEQLKERLAQEGLIGPGRVRPPRPLPYLPRRIGVVTSRTGAALQDFLRVLHSRNPRQSVLVADARVQGEGSAVEVARAIERLARTDVDVIVVTRGGGSVEDLWTFNEERVARAIFASPVPVVSAIGHEIDFTISDFVADLRAPTPSAAAERLAPVLADLELTLATQAGRLRRAMERRVLELREEQGQLASRLEDPRRAINHQRLHLSEQVESMMRVLRPAVRGHREELRSLTERLQRARPQARLGEQRAHLLKLAMRLSEAVRAGVATRHGALATARLGLERASPAAQVSRERARLAAHRARLLALQQGALADAQKRFQRLEGRLDAMSPLKVMSRGYSVVFRQRDGAVVRTGADVQVGERLGLKLASNGAKSLGGCEEIEATVTAVKGPVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3N9</accession>
    <name>Q1D3N9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554561.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4566"/>
    <dbReference type="EnsemblBacteria" id="ABF87513">
        <property type="protein sequence ID" value="ABF87513"/>
        <property type="gene ID" value="MXAN_4566"/>
    </dbReference>
    <dbReference type="GeneID" id="41361867"/>
    <dbReference type="KEGG" id="mxa:MXAN_4566"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692521_0_0_7"/>
    <dbReference type="OMA" id="DQQTVHW"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="18558" checksum="F846126D0EF326B5" modified="2006-07-11" version="1">MSQPIFRTATPVAGADAPAFRIRRARRGDAEAMASLLKELGYPQGTDQQTVHWVVSHPEIEIFVAGDPQDRPVGMVSFSHRPQLRLRGRVGTIDELVVTETWRRRGVGRALIRQILERCKVLSAKQLQLVSPMTTTPETRNFYTACGFTEIDSGVFRHVDTESQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U8</accession>
    <name>Q1D3U8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554502.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4506"/>
    <dbReference type="EnsemblBacteria" id="ABF89998">
        <property type="protein sequence ID" value="ABF89998"/>
        <property type="gene ID" value="MXAN_4506"/>
    </dbReference>
    <dbReference type="GeneID" id="41361813"/>
    <dbReference type="KEGG" id="mxa:MXAN_4506"/>
    <dbReference type="eggNOG" id="ENOG5031K6D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899167_0_0_7"/>
    <dbReference type="OMA" id="NAWRGSR"/>
    <dbReference type="OrthoDB" id="1499517at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="34402" checksum="65C4B7B93CFB73EF" modified="2006-07-11" version="1">MMTMSPPNDALLDAETRDRLHYDTGVLLDAGDFTAEQTYHRGRLTRALAYLHGVGTVAGLKVSHHEGAEPEHEELRVSAGLALDPFGRLVEVPTDACLKLDRWYWQEPLEMADFGVFTPAEYRLSPDAAGFPPTGVVADLFLRFLQCERGKTPAFAAGPFDAMDAVVASRIRDGYELRLVPRSTAYPPPEVPKSPFPDPVDEPDPVQRRIKLRQAVFNAWRGSREQELAKLWSDTFIPASLLTDPTQPDLKMRDPAWVFLARVVIGATGVEDVRGTEVRPTRQGNVYVDNDLRPFSLSTAALARWMGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z9</accession>
    <name>Q1D3Z9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90378">
        <property type="protein sequence ID" value="ABF90378"/>
        <property type="gene ID" value="MXAN_4453"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4453"/>
    <dbReference type="HOGENOM" id="CLU_210281_0_0_7"/>
    <dbReference type="OMA" id="MLDAYVI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="58" mass="6988" checksum="313F5B2B7703D864" modified="2006-07-11" version="1">MLDAFIIEEIKRRERRREEHDRPVVELPLPVPDDRPRRRTETEDDKPQRGVVVIDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D485</accession>
    <name>Q1D485_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, outer membrane receptor (OMR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554366.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4365"/>
    <dbReference type="TCDB" id="1.B.14.1.23">
        <property type="family name" value="the outer membrane receptor (omr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92532">
        <property type="protein sequence ID" value="ABF92532"/>
        <property type="gene ID" value="MXAN_4365"/>
    </dbReference>
    <dbReference type="GeneID" id="41361676"/>
    <dbReference type="KEGG" id="mxa:MXAN_4365"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312561_0_0_7"/>
    <dbReference type="OMA" id="GFHRTAI"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188349" evidence="6">
        <location>
            <begin position="24"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="262"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="497"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="938" mass="101389" checksum="8FC559F3E5360D9B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D546</accession>
    <name>Q1D546_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554056.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4049"/>
    <dbReference type="EnsemblBacteria" id="ABF91254">
        <property type="protein sequence ID" value="ABF91254"/>
        <property type="gene ID" value="MXAN_4049"/>
    </dbReference>
    <dbReference type="GeneID" id="41361379"/>
    <dbReference type="KEGG" id="mxa:MXAN_4049"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433379_0_0_7"/>
    <dbReference type="OMA" id="YAHGVCM"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="48"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="324"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="492"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="689" mass="75152" checksum="1ED0F2C002C7E58F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5D8</accession>
    <name>Q1D5D8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3955"/>
    <dbReference type="EnsemblBacteria" id="ABF89395">
        <property type="protein sequence ID" value="ABF89395"/>
        <property type="gene ID" value="MXAN_3955"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3955"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360461_0_0_7"/>
    <dbReference type="OMA" id="HYYFVME"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="148"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="727" mass="78314" checksum="FEF5837807BA0A52" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5H0</accession>
    <name>Q1D5H0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553933.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3923"/>
    <dbReference type="EnsemblBacteria" id="ABF87457">
        <property type="protein sequence ID" value="ABF87457"/>
        <property type="gene ID" value="MXAN_3923"/>
    </dbReference>
    <dbReference type="GeneID" id="41361254"/>
    <dbReference type="KEGG" id="mxa:MXAN_3923"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="WVQTPEY"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114504" checksum="1C9DCC8443F07226" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5P4</accession>
    <name>Q1D5P4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553859.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3847"/>
    <dbReference type="TCDB" id="2.A.37.3.1">
        <property type="family name" value="the monovalent cation:proton antiporter-2 (cpa2) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90592">
        <property type="protein sequence ID" value="ABF90592"/>
        <property type="gene ID" value="MXAN_3847"/>
    </dbReference>
    <dbReference type="GeneID" id="41361180"/>
    <dbReference type="KEGG" id="mxa:MXAN_3847"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031031_2_0_7"/>
    <dbReference type="OMA" id="FRHNPMV"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="39"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="432" mass="44436" checksum="865ED298814ECA77" modified="2006-07-11" version="1">MTGAVIRLLLLMVLLAIISRAQVLRADSGTPVMLAAGALLLCGLFAGKVAKGLGLPRLTGYLLVGVAVGPYALGFIPNAGVKGLELVKGLAVSLIALVAGTELRLGLIRRVGARVALLCAAVCGVTFLVCFGATFALKPLLPFLADMTVPQALAVSALLSTVVVSFSPTVTIAIVQETSARGAFTEFLMALVIIGDLLVMVAFALAAGLTKASFGGGLDVTELLGGVGWELFGSVVVGLVLAVGMLVYMRGVKQELPLFLVGLCFAAAEGGTRLHLSPLLVSLAAGALIANLDEHAGERIHNAIQQAGLPVFALFFAAAGAGLKLDSLLTVGPAAMLLVALRGVAIWLSCRRFAPADDPRLKRYLWMGLISQAGVTFGLAALVSRTFPTFGPQVEVLIVAMITAHELVGPVLTRRALAASGEIRADDAQGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X3</accession>
    <name>Q1D5X3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PQQ enzyme repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553781.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3768"/>
    <dbReference type="EnsemblBacteria" id="ABF88867">
        <property type="protein sequence ID" value="ABF88867"/>
        <property type="gene ID" value="MXAN_3768"/>
    </dbReference>
    <dbReference type="GeneID" id="41361100"/>
    <dbReference type="KEGG" id="mxa:MXAN_3768"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713350_0_0_7"/>
    <dbReference type="OMA" id="TEKWRFK"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="40971" checksum="1B1C5144FF6394AA" modified="2006-07-11" version="1">MTMRLVSWKRWLGGAVAAGLLGGCGGVRYYGNPELPRPPSNTPLEYFSVNWWAPLAPPQTLEYGPRETATPAYDAVSRTTVALTRDGFARGVGPDGQVKWKYKTGSRFNAGARVVDGVAYVPGGDGVLYALDAASGEEKWKYVAGEALATVPVVANGLVLVASESDTLFAVKIADGQWAWQYRRDPPTGFTVRGASRPLVREGVAYVGFSDGFVVALSVDDGGVTWERSLSGAGSEFLDVDSSPVMDAAGQLYVASYKSGIFALESESGDLVWNTAVAGMTSLLVSGQVLFAAGDGRVDAYLAETGRLLWSHPLGERAAFAPVFAQGMLLVPTSSSLLFLEPKTGRSRVSWNPGSGITAPPFAAGRQVFVLSNNGYLYSLNMNGIDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X5</accession>
    <name>DER_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">MXAN_3766</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553779.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D5X5"/>
    <dbReference type="SMR" id="Q1D5X5"/>
    <dbReference type="STRING" id="246197.MXAN_3766"/>
    <dbReference type="EnsemblBacteria" id="ABF88752">
        <property type="protein sequence ID" value="ABF88752"/>
        <property type="gene ID" value="MXAN_3766"/>
    </dbReference>
    <dbReference type="GeneID" id="41361098"/>
    <dbReference type="KEGG" id="mxa:MXAN_3766"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_7"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_1000099141" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="183"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="359"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="236"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <sequence length="459" mass="50814" checksum="E1F050CA27C89436" modified="2006-07-11" version="1">MKPLVAIVGRPNVGKSTLFNRLVGRRIALVQDEPGVTRDRHYADAEWEGRQFTFIDTGGFVPGDEDQLLQQVREQAQLAVDECDVIVFVTDARAGLTAADEAVANYLRKSGKPVVLAANKLDNTSGQMQALAGEFYRLGLGDVQALSAEHGLGMQELFDSVVARLPPKEEGEDAEAPPDDGIIRLAIIGRPNVGKSTLVNAILKEKRVVASDVAGTTRDPVDSELTYKDRKLLLTDTAGIRRKKSIAQRVEQFSVVAALKVMERSDVAVLLMDATEPAVDQDAKLAGLAEERGRALVIVVNKWDLVGADQRRQETYRESLKHSLKFVGYAPILFTSALTGSKVEKVVDVATELADQFRFRAPTPQLNRLLDHMVDNHPAPIVRGKPLRMYYIAQVAAAPPTFTITVNHPDGVPDMYKRYITNQLRKTFDLRVPIRLIFKGRPGQAKREARKRPQRQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z2</accession>
    <name>Q1D5Z2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553762.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3749"/>
    <dbReference type="TCDB" id="2.A.6.7.4">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86312">
        <property type="protein sequence ID" value="ABF86312"/>
        <property type="gene ID" value="MXAN_3749"/>
    </dbReference>
    <dbReference type="GeneID" id="41361082"/>
    <dbReference type="KEGG" id="mxa:MXAN_3749"/>
    <dbReference type="eggNOG" id="COG4258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009099_1_1_7"/>
    <dbReference type="OMA" id="AFKIYYV"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="310"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="885" mass="95489" checksum="6B55E83DE45AA3E3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D653</accession>
    <name>Q1D653_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltokinase</fullName>
            <ecNumber evidence="3">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553701.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3683"/>
    <dbReference type="EnsemblBacteria" id="ABF87990">
        <property type="protein sequence ID" value="ABF87990"/>
        <property type="gene ID" value="MXAN_3683"/>
    </dbReference>
    <dbReference type="GeneID" id="41361018"/>
    <dbReference type="KEGG" id="mxa:MXAN_3683"/>
    <dbReference type="eggNOG" id="COG3281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029675_0_0_7"/>
    <dbReference type="OMA" id="TAFCDGY"/>
    <dbReference type="OrthoDB" id="268166at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="7">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="6">
        <location>
            <begin position="122"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="49641" checksum="9CEAA239C4E68C36" modified="2006-07-11" version="1">MTTLDLTKLPDYLKHQRWFSGKAWPIKHVTVMDHAAVESGGCSFSLAVVEVIYELGSPERYLLPVHPSTEGVRDALESDECLRGLFDLIRTGGQVASASGRVQGEWIGGQDGLLALPASPEVRRLQVEQSNTSVVLGEKVILKIIRKLEAGVNPEHEVGRFLATKTSFRATPTLLGALHLEGAAGATLAVAHRFVPDATDGWKYTLDRLRQERAVGPRFQSEMRDLGTRLGELHLAFASATEEDPAFTPEPLLQEDLQRWSASIVGELGVTLADASRQNPELENRREDLIEHAKRLAQVPPSGQKIRIHGDLHLGQVLRANNQWIIFDFEGEPARSFTARREKYSALRDVAGMIRSFDYAEATVALEGGTPHERISTMRDAFVEGYRQVTRGAPFLPSDEDTFDVMLRAFELEKLLYEVRYEMQNRPDWVRIPLQALLRMEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D664</accession>
    <name>Q1D664_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cation efflux system protein czcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553690.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3672"/>
    <dbReference type="TCDB" id="2.A.6.1.10">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87768">
        <property type="protein sequence ID" value="ABF87768"/>
        <property type="gene ID" value="MXAN_3672"/>
    </dbReference>
    <dbReference type="GeneID" id="41361007"/>
    <dbReference type="KEGG" id="mxa:MXAN_3672"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_3_7"/>
    <dbReference type="OMA" id="AGDYCRE"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188428" evidence="3">
        <location>
            <begin position="27"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="196"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="520" mass="54821" checksum="A76E9EBC233CDC34" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D693</accession>
    <name>Q1D693_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthase MxcG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3643"/>
    <dbReference type="EnsemblBacteria" id="ABF87167">
        <property type="protein sequence ID" value="ABF87167"/>
        <property type="gene ID" value="MXAN_3643"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3643"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_7"/>
    <dbReference type="OMA" id="AFEWVER"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="970"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1454" mass="156561" checksum="FB5D26E4A520E6E8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D8</accession>
    <name>IHFA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integration host factor subunit alpha</fullName>
            <shortName evidence="1">IHF-alpha</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ihfA</name>
        <name evidence="1" type="synonym">himA</name>
        <name type="ordered locus">MXAN_3596</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002639669.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6D8"/>
    <dbReference type="SMR" id="Q1D6D8"/>
    <dbReference type="STRING" id="246197.MXAN_3596"/>
    <dbReference type="EnsemblBacteria" id="ABF88874">
        <property type="protein sequence ID" value="ABF88874"/>
        <property type="gene ID" value="MXAN_3596"/>
    </dbReference>
    <dbReference type="GeneID" id="41360942"/>
    <dbReference type="KEGG" id="mxa:MXAN_3596"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_1_3_7"/>
    <dbReference type="OMA" id="IYVRGFG"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00380">
        <property type="entry name" value="IHF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00987">
        <property type="entry name" value="himA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000277746" description="Integration host factor subunit alpha">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="129" mass="14300" checksum="9AE2D1D64E05C0CE" modified="2006-07-11" version="1">MTKADIIEGVYEKVGFSKKESAEIVELVFDTLKETLERGDKIKISGFGNFQVRQKKARVGRNPQTGKEIEISARRVLTFRPSQVLKSALNGEAPPEDHAEIDAREEAAADAAEARGEDFDEEGMEDMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6G9</accession>
    <name>Q1D6G9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M36 (Fungalysin) family</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553590.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3564"/>
    <dbReference type="EnsemblBacteria" id="ABF88441">
        <property type="protein sequence ID" value="ABF88441"/>
        <property type="gene ID" value="MXAN_3564"/>
    </dbReference>
    <dbReference type="GeneID" id="41360909"/>
    <dbReference type="KEGG" id="mxa:MXAN_3564"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002091_0_0_7"/>
    <dbReference type="OMA" id="GFNNANM"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1756"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="1400"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1780" mass="185184" checksum="5B3C2F028819A0B0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Y0</accession>
    <name>Q1D6Y0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553429.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3396"/>
    <dbReference type="EnsemblBacteria" id="ABF90443">
        <property type="protein sequence ID" value="ABF90443"/>
        <property type="gene ID" value="MXAN_3396"/>
    </dbReference>
    <dbReference type="GeneID" id="41360743"/>
    <dbReference type="KEGG" id="mxa:MXAN_3396"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_6_3_7"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17669" checksum="54F52FF429CAB5E4" modified="2006-07-11" version="1">METSSLQEVVAPEGICYGCGTKNPHGLHIQSYWDEDGIHVVARHTPDARYSGWPELVYGGLIAMLVDCHSNWTAMAYHYRAEGRSPGSSPAIECVTGSLGVKFIKPTPMGVPLTLRARVEGEVGRKSRVLCEVFAGETLTAVGDSIFVRVDTAQLKAAAHGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D755</accession>
    <name>Q1D755_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ORF">MXAN_3319</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553355.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3319"/>
    <dbReference type="EnsemblBacteria" id="ABF86645">
        <property type="protein sequence ID" value="ABF86645"/>
        <property type="gene ID" value="MXAN_3319"/>
    </dbReference>
    <dbReference type="GeneID" id="41360672"/>
    <dbReference type="KEGG" id="mxa:MXAN_3319"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_7"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF86645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="48710" checksum="63D5D4439AD30539" modified="2006-07-11" version="1">MALNAFANVFRIAELRSRLAYTLALLAVYRIGIFINTPGVDRSAMNAFMDAQKQSGGLVSLFNLFSGGALEQMSIFGLGIMPYVSASIIMQLLAVVVPSLERLQKEGAGGRQKINQYTRYGTIALSVVQGIGISRWLASLGRSDGGQSGFNQVVVPDDSVWFTFMTVVSLTAGTAFIMWLGERITERGIGNGISLIIFAGIVAGLLPGAKQLLDLTRQDVISMAEVLALVVFMLIIIAAVVYVERGMRRIPIQYAKRMAGRRMFAGQATYFPMKVNTSGVIPPIFAGAVLSFPATLGTWFPFLQGFQRAIEGNLWIYNGLFVVMVIFFAYFYTALTFRPDDVADNIKKQGGYIPGIRPGRQTAEFIERVLNRLTFGGAIYLSIVCVIPSVISGLLGVRFTFGGTALLIVVGVALDTVQQIEGHLISRNYEGFAGPRGPRIRGRVRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D784</accession>
    <name>Q1D784_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3290"/>
    <dbReference type="EnsemblBacteria" id="ABF90560">
        <property type="protein sequence ID" value="ABF90560"/>
        <property type="gene ID" value="MXAN_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3290"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_469070_0_0_7"/>
    <dbReference type="OMA" id="PCPEVFV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="169"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="403"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="530" mass="57469" checksum="55F6957B854366F3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F2</accession>
    <name>Q1D7F2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553267.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3222"/>
    <dbReference type="EnsemblBacteria" id="ABF86332">
        <property type="protein sequence ID" value="ABF86332"/>
        <property type="gene ID" value="MXAN_3222"/>
    </dbReference>
    <dbReference type="GeneID" id="41360576"/>
    <dbReference type="KEGG" id="mxa:MXAN_3222"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_4_1_7"/>
    <dbReference type="OMA" id="LLWCNAR"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16453" checksum="840862C93FBF1FAD" modified="2006-07-11" version="1">MSATDIRKIPAQDTRGLRHAILRPNQPPEMAVYPGDDDADTLHLGVYTEGRLVGVASLYREPPPDALRATTAWRLRGMAVDATLRGHGHGAALLKACMEHAARQGGSQVWCNARMTASGFYRAQGFAQRGEPFDLPGIGPHHLMWRNLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7K7</accession>
    <name>Q1D7K7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3163"/>
    <dbReference type="EnsemblBacteria" id="ABF90826">
        <property type="protein sequence ID" value="ABF90826"/>
        <property type="gene ID" value="MXAN_3163"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3163"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609468_0_0_7"/>
    <dbReference type="OMA" id="HVTYANE"/>
    <dbReference type="OrthoDB" id="692376at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188240" evidence="2">
        <location>
            <begin position="24"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="330"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="449" mass="48233" checksum="F90F81DAADC22409" modified="2006-07-11" version="1">MAAISVQVPLLVFMALLATSARAAEPSAVEQRAREDLDRQLQEMVKTPPPEIVISFEGLPGAGTSRGYKLVEADFLVNGQPLAIPGLDKLNGPGLHRLAVLTVEEGSYTLVSHVTYANESWNLFSEESGFLWKLTASVTVQVQRGLRARVRVLPAINPTAPDPRLKLKLSHDVKAEMTAAMADVAIPDVPDAGAPVAAVAQAPAKPTPPPVTAPISPTPPVATPVKTVEAPEQGPVAPAKLLLKVLAGKRPAAATVYVKSATGAPQRVMVDRKARKPVEVMLPPGEYRLDVLSQGYLAQTRKVTLSREAVPTVSFTLAKAPVSKSQKVRLKKEVVELPRMPRFAEKQAAPRNGTTAGLALLMDMFVRDEKLRLRIEGHTDNRERPAAAARKTLSEARAAAVAKALVDAGLDASRIETVGLGDTRPKAPNLLPRGRELNRRVEFVLVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L9</accession>
    <name>Q1D7L9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553201.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3151"/>
    <dbReference type="EnsemblBacteria" id="ABF92845">
        <property type="protein sequence ID" value="ABF92845"/>
        <property type="gene ID" value="MXAN_3151"/>
    </dbReference>
    <dbReference type="GeneID" id="41360510"/>
    <dbReference type="KEGG" id="mxa:MXAN_3151"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_16_2_7"/>
    <dbReference type="OMA" id="RFQAMQV"/>
    <dbReference type="OrthoDB" id="1661500at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="32673" checksum="B91F22F04AB7A8DD" modified="2006-07-11" version="1">MKRAHLDEIFAFMAVVDAGSFVSGGRAIGLTRSAAGKALARLESRLGVRLLNRTTRHLSLTDDGRVFHEHCQQVLAALDDAEASVGDHTGTPRGVLRITVPDAFGRLHVLPVLKKYLQTWPDVQVEVSFTDRVADIIEEGYDLAVRINVTSTDTRLVSRLVAQHRVFVCAAPSYLAARGEPQTLEELATHDCLLFSSRARRQRWRLRPKGGAYVTVEGQSRLRLDSGEAIRDAAVAGLGIAFLPSFLVDEDLARGRLKALLPSCETEVVRIMAFYPSKRHLPAKVRRFIDLLVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7S5</accession>
    <name>Q1D7S5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3095"/>
    <dbReference type="EnsemblBacteria" id="ABF88467">
        <property type="protein sequence ID" value="ABF88467"/>
        <property type="gene ID" value="MXAN_3095"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3095"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="GSNTYQP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="142"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="449" mass="49989" checksum="465EE228783DB735" modified="2006-07-11" version="1">MEVEGGRDTPLHVTLPYEHARRGYDASTVRRFRLTVAEGPNMGTTWESTGDTCSVGSHPLNDFAVEDSTVSRFHCEVRIGPRGPQVKDLDSLNGVIVDGVQVVEGVLRSGSLLRLGRVVLRFDFSAENNRLPLSENSRFGTLVGASVAMRGCFAMMERAAGRDVTVLLEGETGTGKSQAALAIHQASPRRDAPFLIVDCGAIPAHLLESELFGHEKGAFTGAVQRRAGVFEEADGGTVFLDEIGELPAELQPKLLRVLENREIRRVGSNTYQPVNVRLLAATHRDLRAEVNAGRFRSDLFFRLAVLRLLLPPLRQRPEDLPMLVEGILDLLGADRERTGALRTQDFLARLRHAAWPGNVRELRNYLERCLVFEEAVELSEEEAHRSGPPEVDPSQPYADQRRHVVDDFERRYLRALLEKHQGKVAQAAVTAGMDRVHLYRLLRRHGIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7S8</accession>
    <name>Q1D7S8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553142.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3092"/>
    <dbReference type="EnsemblBacteria" id="ABF88757">
        <property type="protein sequence ID" value="ABF88757"/>
        <property type="gene ID" value="MXAN_3092"/>
    </dbReference>
    <dbReference type="GeneID" id="41360453"/>
    <dbReference type="KEGG" id="mxa:MXAN_3092"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006681_0_0_7"/>
    <dbReference type="OMA" id="ATARDWM"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1274" mass="135947" checksum="C5F27E6016969D22" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D828</accession>
    <name>Q1D828_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553042.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2986"/>
    <dbReference type="EnsemblBacteria" id="ABF92280">
        <property type="protein sequence ID" value="ABF92280"/>
        <property type="gene ID" value="MXAN_2986"/>
    </dbReference>
    <dbReference type="GeneID" id="41360348"/>
    <dbReference type="KEGG" id="mxa:MXAN_2986"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029703_1_0_7"/>
    <dbReference type="OMA" id="WIVPLER"/>
    <dbReference type="OrthoDB" id="970174at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="49977" checksum="4AF4CB3B14A5078B" modified="2006-07-11" version="1">MAPPAGYDYDDNPFKLENPSILDIAPPEPKSVEDTGLKMGILSDIALKYLYYAGTGTGMGIADEMRLPWPGVIEHVVDFLATEKLVDLRGGKGFGRASVEFILSEKGREYARDALTRTTYVGPAPVPIEQYNALITSQTEETPVVSQEELVMALSHLTVPAELMDKLGPAVNSGRSLFLYGSPGNGKTSLAEAVSHMFGGEVFVPHCLEIGNQIIQVHDRLIHTPVSLEVGRDASGRRQTFEMDNRWLVCRRPSVVVGGELTLAMLDLIYSESTRFYEAPFQVKANGGMLLIDDFGRQKVHPTDLLNRWIVPLEKRVDFLTLHTGKKFEIPFDQLLVFSTNLDPKELVDEAFLRRIKYKIEVGNPDEEAYREIFSRVCEAAGIPYVDQAVTYLIEHYYKPRSMELRSCHPRDLVSLIRDAARYRQIPPALSKDLLDQACEVFLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D848</accession>
    <name>Q1D848_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, Mar family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553022.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2966"/>
    <dbReference type="EnsemblBacteria" id="ABF86271">
        <property type="protein sequence ID" value="ABF86271"/>
        <property type="gene ID" value="MXAN_2966"/>
    </dbReference>
    <dbReference type="GeneID" id="41360329"/>
    <dbReference type="KEGG" id="mxa:MXAN_2966"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_7"/>
    <dbReference type="OMA" id="LTPTQMH"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="21850" checksum="DCAFD72FA2EDAF1E" modified="2006-07-11" version="1">MRRPDDKPAALANRRGDPGAEGQDPPEDGGSEESHGLMEEDVETSTPESRRLHELLIEFSRYRSLKNPLAGICEDLQLTPTQMHALSWLGNDGPVQVGVLALRVGITRKTITGVVDRLESMGLVERTRDVEDRRAVVVRLTEQGSSVFARIDRGMDASLRRVLSLMSPEDRDAVFGILERMLARLTAEAESASGDSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G8</accession>
    <name>Q1D8G8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552905.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2844"/>
    <dbReference type="EnsemblBacteria" id="ABF90951">
        <property type="protein sequence ID" value="ABF90951"/>
        <property type="gene ID" value="MXAN_2844"/>
    </dbReference>
    <dbReference type="GeneID" id="41360215"/>
    <dbReference type="KEGG" id="mxa:MXAN_2844"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_7"/>
    <dbReference type="OMA" id="RRCFELM"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="477" mass="51307" checksum="5AA38CD9890AE0D0" modified="2006-07-11" version="1">MLAERYPYYLANRPRQPNAELAVTHKYSGEVVTHVAVADAAAVEEAIAAAVRAAEPMRKLAPYARQAVLEHCVRRFRERAEELALALCIEAGKPLRDARGEVDRLIDTFKAAAEEAVRGGGEVLNLEVSKRAAGYRGFTQRVPVGPCSFITPFNFPLNLVAHKVAPAIAAGCPFILKPSDRTPVSALIMAEILAETELPEGAFSVLPVRLEDIGPLIEDDRLKLLSFTGSEKVGWELKARAGRKKVVLELGGNAACVVDEAPGAPLDFIADRVAQGAFFQAGQSCISVQRVLVHASLYDALREKLVERAKALRPGHPSDEATTLGPMIDEPAARRLEGWIQQAVQRGARVLAGGGRRGSVLDATVLEGVPEDASLSSEEAFGPVVLLQPFDSFDEALAQVNSGRFGLQAGLFTQDLSRAMKAWDELEVGGVVVGDVPSFRVDTMPYGGVKGSGIGREGVKYAIEDMTELRLLVLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P7</accession>
    <name>Q1D8P7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">moaB</name>
        <name evidence="7" type="ORF">MXAN_2759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552826.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2759"/>
    <dbReference type="EnsemblBacteria" id="ABF90954">
        <property type="protein sequence ID" value="ABF90954"/>
        <property type="gene ID" value="MXAN_2759"/>
    </dbReference>
    <dbReference type="GeneID" id="41360136"/>
    <dbReference type="KEGG" id="mxa:MXAN_2759"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_2_3_7"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="OrthoDB" id="1528139at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="6">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="16471" checksum="44AA8794CC241ABD" modified="2006-07-11" version="1">MHVSTFIVTCSDSRDAARDESGQVLREGLEAAGHGIAGTLVVKDDPEAIRGALDAAREAGARAVLFTGGTGIGRRDCTVETLRPLFEKELPGFGELFRMLSYRQVGSAAMMSRATAGTYQGMILFALPGSPKAVRLALEALILPELGHAVRELSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8U6</accession>
    <name>Q1D8U6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552777.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2710"/>
    <dbReference type="EnsemblBacteria" id="ABF88501">
        <property type="protein sequence ID" value="ABF88501"/>
        <property type="gene ID" value="MXAN_2710"/>
    </dbReference>
    <dbReference type="GeneID" id="41360088"/>
    <dbReference type="KEGG" id="mxa:MXAN_2710"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531906_0_0_7"/>
    <dbReference type="OMA" id="ERILWTG"/>
    <dbReference type="OrthoDB" id="344428at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="56881" checksum="6278BE5EA5A92555" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8V1</accession>
    <name>Q1D8V1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrofolate synthase/folylpolyglutamate synthase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Folylpolyglutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">folC</name>
        <name evidence="17" type="ORF">MXAN_2705</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51912"/>
            <dbReference type="Rhea" id="RHEA-COMP:13257"/>
            <dbReference type="Rhea" id="RHEA-COMP:13258"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:136572"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13088"/>
            <dbReference type="Rhea" id="RHEA-COMP:14300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:134413"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552773.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2705"/>
    <dbReference type="EnsemblBacteria" id="ABF88017">
        <property type="protein sequence ID" value="ABF88017"/>
        <property type="gene ID" value="MXAN_2705"/>
    </dbReference>
    <dbReference type="GeneID" id="41360083"/>
    <dbReference type="KEGG" id="mxa:MXAN_2705"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_7"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="267"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00002714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABF88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="43558" checksum="FB9A9C69F5ABA995" modified="2006-07-11" version="1">MERVQEALAALGHPERRYPALHVAGTNGKGSTCAMTAASLHAAGHRVGLYTSPHLVRVNERIRVDSEDISDADFGLRILEVLERYPSAVSSPMTYFEFGTVVALWHFAQVRVDVAVLETGLGGRLDATTAASPVVTAITPVSFDHMEYLGDTLAAIAGEKAGILKPGVPCVVARQAPEALEAILRKAEQVGAPVRLEGRDFTGERQPDGGLSYRGATWSLDGLSVALRGPHQRQNAAVALACLEALQERGVTAPPEAARAGLASACWPGRLEEVGQQPILLLDGAHNPAGVEVLLASLKDLYPGRRLHLVFGVVGDKDRGPMMRALLPECASVQLTPLETPRSLAPEAYLAEARALCADVTAWPDADAALAAARKRAAANDLVLCTGSLFLVGMMKARMYRNLGAMHQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D920</accession>
    <name>Q1D920_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552704.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2634"/>
    <dbReference type="EnsemblBacteria" id="ABF90920">
        <property type="protein sequence ID" value="ABF90920"/>
        <property type="gene ID" value="MXAN_2634"/>
    </dbReference>
    <dbReference type="GeneID" id="41360010"/>
    <dbReference type="KEGG" id="mxa:MXAN_2634"/>
    <dbReference type="eggNOG" id="COG2952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1552085_0_0_7"/>
    <dbReference type="OMA" id="YVINQMI"/>
    <dbReference type="OrthoDB" id="1293591at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="20162" checksum="702E9C4AE2A953F3" modified="2006-07-11" version="1">MRLYPKVIPIISREAVQQLMQDGDIEVEPMRVADAEMDLSAIMREYLANEERVNQATREALERRGYDYSKFNQVKREMADVRGFKMGDEGIEYVINQMIEFLLISRNVEEVYSADNGLRQKIFAVMKRHLDVDDEIDKEARSRLKHLQEGTSAFDIEYNKTVEQIRRARGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D922</accession>
    <name>Q1D922_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14 15">UvrABC system protein B</fullName>
            <shortName evidence="14">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 21" type="primary">uvrB</name>
        <name evidence="21" type="ORF">MXAN_2632</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 14 15">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552702.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2632"/>
    <dbReference type="EnsemblBacteria" id="ABF88613">
        <property type="protein sequence ID" value="ABF88613"/>
        <property type="gene ID" value="MXAN_2632"/>
    </dbReference>
    <dbReference type="GeneID" id="41360008"/>
    <dbReference type="KEGG" id="mxa:MXAN_2632"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_7"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="25"/>
            <end position="151"/>
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            <begin position="430"/>
            <end position="596"/>
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        </location>
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        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS51194"/>
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        <source>
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            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="704" mass="79216" checksum="1DCE0F3611601D56" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D951</accession>
    <name>Q1D951_MYXXD</name>
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        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">MXAN_2603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
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            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
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        <property type="reaction ID" value="UER00327"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:NAD biosynthetic process"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="34755" checksum="93805DB16A55865E" modified="2006-07-11" version="1">MRAEVDYAKEIQEFKRSMNAVILAHYYQESEVQDLADFVGDSLALAQAAASTKADVIVFCGVHFMAETAKILNPSRQVLLPDLKAGCSLSDRCPPGAFKAFKDKHPNAFVVSYVNSSAAVKAMSDVICTSSNAVKIVNQVPKDRQILFAPDQHLGRYVMKQTGRDMVLWPGSCIVHEIFSEKKLVQLKVEYPEAEVVAHPECEQAVLRHADFIGSTKAILDYAVRSPKQQFIVVTEAGIIHQMKRAAPNKTFIPAPPDNGCACNECPYMRLNTLEKLWRCMKERTPELTMPEDLRERARAPLQRMLDWSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D2</accession>
    <name>Q1D9D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_2522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2522"/>
    <dbReference type="EnsemblBacteria" id="ABF89420">
        <property type="protein sequence ID" value="ABF89420"/>
        <property type="gene ID" value="MXAN_2522"/>
    </dbReference>
    <dbReference type="GeneID" id="41359899"/>
    <dbReference type="KEGG" id="mxa:MXAN_2522"/>
    <dbReference type="eggNOG" id="ENOG50302A9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626066_0_0_7"/>
    <dbReference type="OMA" id="AVLYFWP"/>
    <dbReference type="OrthoDB" id="1571401at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="170" mass="18941" checksum="F6BBDFD21A9EA9FA" modified="2006-07-11" version="1">MRGAMVNVTRSQVVGGVLALLAAGAVLYFWPRQQLTVEEAIRRQVVVMTRAAEAKDVGGVMEHVSERFRSNGQGGWSKKDVRGILTAQVLRGQWVRVFVTNLEVREVSPSEGEFQARFIFGRSQAEKVEHLAADSVLNAYLIEGAFEKEEDGEWRVVRARPESISPTDLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9P5</accession>
    <name>EFG1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 1</fullName>
            <shortName evidence="1">EF-G 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA1</name>
        <name type="ordered locus">MXAN_2408</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552483.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D9P5"/>
    <dbReference type="SMR" id="Q1D9P5"/>
    <dbReference type="STRING" id="246197.MXAN_2408"/>
    <dbReference type="PRIDE" id="Q1D9P5"/>
    <dbReference type="EnsemblBacteria" id="ABF92388">
        <property type="protein sequence ID" value="ABF92388"/>
        <property type="gene ID" value="MXAN_2408"/>
    </dbReference>
    <dbReference type="GeneID" id="41359792"/>
    <dbReference type="KEGG" id="mxa:MXAN_2408"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_7"/>
    <dbReference type="OMA" id="FRVHRDE"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045044">
        <property type="entry name" value="EFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="PTHR43636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263473" description="Elongation factor G 1">
        <location>
            <begin position="1"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="8"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="704" mass="78038" checksum="25AB0AC117341209" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Q3</accession>
    <name>Q1D9Q3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552475.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2400"/>
    <dbReference type="EnsemblBacteria" id="ABF85998">
        <property type="protein sequence ID" value="ABF85998"/>
        <property type="gene ID" value="MXAN_2400"/>
    </dbReference>
    <dbReference type="GeneID" id="41359784"/>
    <dbReference type="KEGG" id="mxa:MXAN_2400"/>
    <dbReference type="HOGENOM" id="CLU_078790_0_0_7"/>
    <dbReference type="OMA" id="ELWDEGR"/>
    <dbReference type="OrthoDB" id="1095639at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011754">
        <property type="entry name" value="Mxa_paralog_2268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09544">
        <property type="entry name" value="DUF2381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02268">
        <property type="entry name" value="TIGR02268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188317" evidence="2">
        <location>
            <begin position="24"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="33829" checksum="06E32B91CD4F38AF" modified="2006-07-11" version="1">MTGSPTFIVLAWGLLWATLAESAAVEAPAGAAVVRRIDVQAGGLATPPEVRISPGLSTTLFFDARIRPEQLALEGRERFQRFGVTEDHLVLVPSPTFREGERLRLEVRFHDGAVPDRAVLDLVVDATRPERQVEIYRHARSAASYRQEVEELRAGMLRLERQVQQLQRSRTGGEYTRESLVADILDESTVMFRHWAPRKVTGDFVVRRASLVRLSPGWAALRLSLLPSEAGKGWMAAGAALTDAQGNRMRTLPPWQEGPLDAAGSSPIIIVLEEPEAADFGRYTLELWDEGRKRTLKLEGFQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y1</accession>
    <name>Q1D9Y1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MJ1316 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552397.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2322"/>
    <dbReference type="EnsemblBacteria" id="ABF86065">
        <property type="protein sequence ID" value="ABF86065"/>
        <property type="gene ID" value="MXAN_2322"/>
    </dbReference>
    <dbReference type="GeneID" id="41359709"/>
    <dbReference type="KEGG" id="mxa:MXAN_2322"/>
    <dbReference type="eggNOG" id="COG1531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2509198_0_0_7"/>
    <dbReference type="OMA" id="YDAHGET"/>
    <dbReference type="OrthoDB" id="162178at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="100" mass="11873" checksum="322124C1209274C2" modified="2006-07-11" version="1">MRTCASPLPASRESAMSDERFTTSREVYHRIQWDPRFDPREFTIGYDAHGETREEMPFAAFVPDGEIPWHRVWYFKRGHQVVWDREQRLDLLNSPQPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y9</accession>
    <name>Q1D9Y9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552389.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2314"/>
    <dbReference type="EnsemblBacteria" id="ABF87110">
        <property type="protein sequence ID" value="ABF87110"/>
        <property type="gene ID" value="MXAN_2314"/>
    </dbReference>
    <dbReference type="GeneID" id="41359701"/>
    <dbReference type="KEGG" id="mxa:MXAN_2314"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_7"/>
    <dbReference type="OMA" id="IINGPRD"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="337" mass="35331" checksum="42915B6FB306A33F" modified="2006-07-11" version="1">MRAYEIQAGFGLDKLVQVERPDPTPGPMQVRVRVKATSLNSRDLMMVEGRYNPRQKLPLIPNSDAAGVVDAVGPGVTRVKPGDRVMSLFSQAWSAGEPTRAAQVSTLGGPLDGALADTVLLHEDGAVPTPAYLSDEEAATLPCAAVTAWSALVTHGALKAGDTVLLQGTGGVSIFALQIARLLGARIIITSSSDAKLARARTLGAHEGINYGTTPDWDKAARALTGGVGVDHVVEVGGAGTFEKSLRAVRPGGTVSVIGVLSGGAGTVPLTPILMQNLRVQGIFVGHRQSFDALNRAFALHTVRPVVDRVFEFSEARAAFEHLKRGAHFGKVVVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA64</accession>
    <name>Q1DA64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, isochorismatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552314.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2238"/>
    <dbReference type="EnsemblBacteria" id="ABF90503">
        <property type="protein sequence ID" value="ABF90503"/>
        <property type="gene ID" value="MXAN_2238"/>
    </dbReference>
    <dbReference type="GeneID" id="41359626"/>
    <dbReference type="KEGG" id="mxa:MXAN_2238"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_1_0_7"/>
    <dbReference type="OMA" id="QFSYDRT"/>
    <dbReference type="OrthoDB" id="1860541at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="23437" checksum="B092BA907A78BE1F" modified="2006-07-11" version="1">MASEPIRDPVKDQLLTPKNSAFVVIDYQPVQVNSIASMDRQLLVNNIVGAAKAAVVYGLPIVHSTVNVKTGLNKPPIPQLRKVLEKFPTYDRTTINSWEDVEFRSAIEATGRKKLILTALWTEACLTFPALDALKAGYEIYVVADAVGGTSVAAHEAGLRRIEQAGGKIISVPQLFCELQRDWSRKETVPAFMDLFIQTGGTAGIQFSYDWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAA8</accession>
    <name>Q1DAA8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2193"/>
    <dbReference type="EnsemblBacteria" id="ABF89275">
        <property type="protein sequence ID" value="ABF89275"/>
        <property type="gene ID" value="MXAN_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2193"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545987_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="18672" checksum="58F5080FBE431FD4" modified="2006-07-11" version="1">MPAGDVSRRLLHLEHGQHVARRALEPGDGRPHVAAWGGFDSRMRTRVVSNLIMGACTVALGVVPHLGVYLAAMGIFGVALPLYNTPATVMLQERVEPAYLGRVFSVMTMLSTALMPLSMLLFGPLAEAVSIEPLLQITGVLVIFLGLLAPLHRRLMSFGEPKRPPVESQDLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAS2</accession>
    <name>Y2022_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0301 protein MXAN_2022</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_2022</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552106.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAS2"/>
    <dbReference type="SMR" id="Q1DAS2"/>
    <dbReference type="STRING" id="246197.MXAN_2022"/>
    <dbReference type="EnsemblBacteria" id="ABF91720">
        <property type="protein sequence ID" value="ABF91720"/>
        <property type="gene ID" value="MXAN_2022"/>
    </dbReference>
    <dbReference type="GeneID" id="41359432"/>
    <dbReference type="KEGG" id="mxa:MXAN_2022"/>
    <dbReference type="eggNOG" id="COG1678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057596_2_1_7"/>
    <dbReference type="OMA" id="IYWGGDF"/>
    <dbReference type="OrthoDB" id="1736059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258843" description="UPF0301 protein MXAN_2022">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <sequence length="181" mass="19512" checksum="8D556440507ADD65" modified="2006-07-11" version="1">MKNLAPGLLLAMPQLGDPNFYRSVVLMLEHSESGSMGLVINRGAPLTLGELARGQNLGIAAGRKEHSVYLGGPVEPQRGFVLHDDTEQREKHSVLPGLFLSVTLDALGPLLTNPNPRLRFCLGYAGWGPRQLESEIAAGSWLFTEATAEAVLGHEPSKLWDTTLRGMGVDPAMLVMGRGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB12</accession>
    <name>Q1DB12_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552017.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1917"/>
    <dbReference type="EnsemblBacteria" id="ABF87126">
        <property type="protein sequence ID" value="ABF87126"/>
        <property type="gene ID" value="MXAN_1917"/>
    </dbReference>
    <dbReference type="GeneID" id="41359331"/>
    <dbReference type="KEGG" id="mxa:MXAN_1917"/>
    <dbReference type="eggNOG" id="ENOG5030SQF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1487527_0_0_7"/>
    <dbReference type="OMA" id="CIGQLAF"/>
    <dbReference type="OrthoDB" id="1456371at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188092" evidence="2">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="21627" checksum="3FAC5CE2206C5904" modified="2006-07-11" version="1">MTPPTPASTLCGIVSRMRNVGMLAVLAAGMATAQSPSPAAPPAPPAATAALEKASDVPDSAKLVRSTQALSGMREVLRSVLGKVEEARRTKDVVKLNCANEKLTQIKGLLRISEQADVSLQEAVSRQESSSSEHEFTKVMIARQKVGQLRSEAEECIGQLAFRTDENLFVEVEEPNNLPGGDPTRPPTPDIVLVRPPPASPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB32</accession>
    <name>Q1DB32_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551997.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1896"/>
    <dbReference type="EnsemblBacteria" id="ABF91479">
        <property type="protein sequence ID" value="ABF91479"/>
        <property type="gene ID" value="MXAN_1896"/>
    </dbReference>
    <dbReference type="GeneID" id="41359311"/>
    <dbReference type="KEGG" id="mxa:MXAN_1896"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_0_0_7"/>
    <dbReference type="OMA" id="YRPPEAW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="662" mass="70534" checksum="0831D593125E1ECB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB90</accession>
    <name>Q1DB90_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1837"/>
    <dbReference type="EnsemblBacteria" id="ABF86272">
        <property type="protein sequence ID" value="ABF86272"/>
        <property type="gene ID" value="MXAN_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1837"/>
    <dbReference type="HOGENOM" id="CLU_1925322_0_0_7"/>
    <dbReference type="OMA" id="GVKYART"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14286" checksum="D96D074658240F58" modified="2006-07-11" version="1">MTPMALTAFTSRLGLGQGRIRPQRATPASGEYLFVLGDEEPGRRFELAPGDFVEVTQPVDVTGVHLVRTALRLRVPAGVPAGLAWEASLVVDGVKYARTLGRPGRERLVGDMAANVSKLSGVHTVGVRLELVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD8</accession>
    <name>Q1DBD8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1787"/>
    <dbReference type="EnsemblBacteria" id="ABF89554">
        <property type="protein sequence ID" value="ABF89554"/>
        <property type="gene ID" value="MXAN_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1787"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2274336_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="12368" checksum="94A5E2F72FE34D50" modified="2006-07-11" version="1">METRRANRSAHFIEQWARLAQWLKLWPWCRREHQCPRGNLVADADEMAQPLLRKTYCCPWQTSYAERVIGSIRRELLDHVVILNEAHARRLLREYKRYYNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE3</accession>
    <name>Q1DBE3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1782"/>
    <dbReference type="EnsemblBacteria" id="ABF87847">
        <property type="protein sequence ID" value="ABF87847"/>
        <property type="gene ID" value="MXAN_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1782"/>
    <dbReference type="eggNOG" id="COG2105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2826619_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="66" mass="7884" checksum="7D5390EE35003475" modified="2006-07-11" version="1">MYEVDALMLAALDRLESHPRFYRRTPITLDDVGRVEAYLFPKERLAGRPIIESGCWRRYLKERKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF6</accession>
    <name>Q1DBF6_MYXXD</name>
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        <submittedName>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="246197.MXAN_1767"/>
    <dbReference type="EnsemblBacteria" id="ABF89378">
        <property type="protein sequence ID" value="ABF89378"/>
        <property type="gene ID" value="MXAN_1767"/>
    </dbReference>
    <dbReference type="GeneID" id="41359193"/>
    <dbReference type="KEGG" id="mxa:MXAN_1767"/>
    <dbReference type="HOGENOM" id="CLU_2899466_0_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="62" mass="6704" checksum="45713F197739FB25" modified="2006-07-11" version="1">MVIARAKYRDADAADTAEPTSVTAPLPPQLLPRALATPSLLAHILSDKFCDGLPFHRQECMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBK5</accession>
    <name>Q1DBK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF86850">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="19541" checksum="AE53A6AE78850C87" modified="2006-07-11" version="1">MARRLPRPSRSEERNLHMPPPPIRRDPPKPPPVKPSPATLQPPKSKRAPATQKPVPAATQPPQDSFKPTSPGTTPPRLQMGPYVPGHEPKNDKPQTQPAPAAPKKEEQDSKGLENWETYPKPLDTTVTARQQLQDGKDRVQTWKDNRSAGHGLAKTMKEGVKDNFAKSIEGGKNPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBM0</accession>
    <name>Q1DBM0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1702"/>
    <dbReference type="EnsemblBacteria" id="ABF89015">
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    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1702"/>
    <dbReference type="eggNOG" id="ENOG502Z8K2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823426_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="38287" checksum="FDE009CEF2D34265" modified="2006-07-11" version="1">MGETSGRTYNQNHAPRRYMRGHRRVSVYTSWSYPGEANRNPAEMDNRFSTMTEVRRALWPHYESPQWADPLRFQQGVAGSLELFFWAWVKFQRVIEEVTGHRVPMFQRVDQAGFPLPLDERVLADADTLLVFGLDHNVTGQVAAPEEIEAVRAFLEREGTCLVIGPHHDVGHSPDLEERALEYAHHGDALVPRQQRFGGYARSLMKGLGIPVENRWGLRPAVVEGTNRSVPLTVMEDLDTRGWLSGVQNFNFHMHLPHYAVTTEDSHSLRVLAKQPIDLTRPHPFTNEGNTEFNALVWMPPGDGRAGDVLVADSTIFSTLFGADESLVRFWKNLATAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC24</accession>
    <name>Q1DC24_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551658.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1547"/>
    <dbReference type="EnsemblBacteria" id="ABF92734">
        <property type="protein sequence ID" value="ABF92734"/>
        <property type="gene ID" value="MXAN_1547"/>
    </dbReference>
    <dbReference type="GeneID" id="41358991"/>
    <dbReference type="KEGG" id="mxa:MXAN_1547"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="HHADRVW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="33360" checksum="F0072E7A9EA1626E" modified="2006-07-11" version="1">MIQVEGLTKYYGEHAAIRELAFTISQGEVIGFLGLNGAGKSTTLKVLGCVLMPTSGRVVIDGHDVVSNAHEVRQRIGYLPDVPPLYDEMTVGEYLTYVAQLRGVTSRDTASRVGEAEEKTGLRDVHGELISTLSHGYRQRVGVAQALVHKPALLILDEPTSGLDPRQIVEMRDVIRGLKGAHTVLVSSHILPEISQTCDRLLIIHKGMLVAQGTEEELAAKMGGRGTIELEVRGDKARAVEVLQRFGSVEVDRASDGLVALTVRASPDQRPQVAQAVVGAGLELLRLDQGAGQLESIFLRLTHGQEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC82</accession>
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        <submittedName>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92707">
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        <property type="gene ID" value="MXAN_1484"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012992_0_0_7"/>
    <dbReference type="OMA" id="FIFETEP"/>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
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        <property type="entry name" value="Clp_ATPase_C"/>
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    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="72"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="340"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PCRF" evidence="6">
        <location>
            <begin position="734"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="685"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="966" mass="105947" checksum="13763573A8B0BA76" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCH5</accession>
    <name>Q1DCH5_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">S1 RNA binding domain protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1391"/>
    <dbReference type="EnsemblBacteria" id="ABF90621">
        <property type="protein sequence ID" value="ABF90621"/>
        <property type="gene ID" value="MXAN_1391"/>
    </dbReference>
    <dbReference type="GeneID" id="41358838"/>
    <dbReference type="KEGG" id="mxa:MXAN_1391"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_7"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="643"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="783" mass="84768" checksum="7B9F351EA0FE54C4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK8</accession>
    <name>Q1DCK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551475.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1358"/>
    <dbReference type="EnsemblBacteria" id="ABF88717">
        <property type="protein sequence ID" value="ABF88717"/>
        <property type="gene ID" value="MXAN_1358"/>
    </dbReference>
    <dbReference type="GeneID" id="41358804"/>
    <dbReference type="KEGG" id="mxa:MXAN_1358"/>
    <dbReference type="HOGENOM" id="CLU_120930_0_0_7"/>
    <dbReference type="OMA" id="KGSASAW"/>
    <dbReference type="OrthoDB" id="1726469at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21000" checksum="5A7D76D6B0E4F492" modified="2006-07-11" version="1">MIWVIAAPFRGSGSDVDRPACPDAARPKRRAEPPKGLTMSGITLVRNVVAGLAMFVGFTSMAAPAPVRAEPLYFAVEVRRDGRLVAQPKLLGETGRTLRAERRRPGAPLPDYRLVLTPKAEGQSFLLQLDLLLPEAKGHSELALLHGQERKLQLGRVPGELEVSLLLMKVDSPEFRALMQLGESGGKSLSTSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCU5</accession>
    <name>Q1DCU5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-Q tRNA(Asp) synthetase</fullName>
            <shortName evidence="5">Glu-Q-RSs</shortName>
            <ecNumber evidence="5">6.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gluQ</name>
        <name evidence="8" type="ORF">MXAN_1271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551388.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1271"/>
    <dbReference type="EnsemblBacteria" id="ABF88167">
        <property type="protein sequence ID" value="ABF88167"/>
        <property type="gene ID" value="MXAN_1271"/>
    </dbReference>
    <dbReference type="GeneID" id="41358717"/>
    <dbReference type="KEGG" id="mxa:MXAN_1271"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_0_0_7"/>
    <dbReference type="OMA" id="DADTERC"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01428">
        <property type="entry name" value="Glu_Q_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022380">
        <property type="entry name" value="Glu-Q_tRNA(Asp)_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03838">
        <property type="entry name" value="queuosine_YadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="5">
        <location>
            <begin position="243"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="315" mass="34824" checksum="AA6105A36BE0ADEA" modified="2006-07-11" version="1">MSQVRGRFAPSPTGRMHLGNIRSALLGWLQARAAHGRFLLRIEDLDRARCKPQYVDDLLRDMEWLGLDWDEQPVFQSQRDGLYRDAQARLEQAGRVYPCFCTRAEIARAASAPHGLSDEGPRYPGTCAHLTREQISERARTRPPAYRFRAVPGEVRFVDGLQGSYSQDVDAVVGDFVVRRNDGVASYQLAVVVDDAATDITHVLRGDDLLSSTPRQLQLYAALSLRAPDFLHVPLVLGEDGKRLAKREGAFALAELRERGVAPERVLGLLASWSGWGDGGPLTLAELVHSFRPERLPRTPIVAGEAALREALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCV3</accession>
    <name>Q1DCV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551380.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1263"/>
    <dbReference type="EnsemblBacteria" id="ABF91895">
        <property type="protein sequence ID" value="ABF91895"/>
        <property type="gene ID" value="MXAN_1263"/>
    </dbReference>
    <dbReference type="GeneID" id="41358709"/>
    <dbReference type="KEGG" id="mxa:MXAN_1263"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015306_0_0_7"/>
    <dbReference type="OMA" id="WYQQYVG"/>
    <dbReference type="OrthoDB" id="1459011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188494" evidence="4">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="29403" checksum="5DBEDE3CB3EBC019" modified="2006-07-11" version="1">MRLAFVLSVILALAPPVAFAQRGKNAAALIKDGERLYQGGKYREAADALKKAHEAQPHPRLIYNIAISLENAGELREAVTWYQQYVGATDGTDPTLLKRSARSIDRLRVLIEKEDQVAAASNAERQRLQDEADTARRQAEEEQLAARRAEEESRRQQEAELQRALTSYKRQRIGAFAAAGVGAAGVVAGVLFGMQARDAREQFDGATRVETKEEFADKTRSRALLADVGFGVGLAGVITAIVLYPKDGPPVAGEVRVTMAPKGAGAGMAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD34</accession>
    <name>Q1DD34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1179"/>
    <dbReference type="EnsemblBacteria" id="ABF89272">
        <property type="protein sequence ID" value="ABF89272"/>
        <property type="gene ID" value="MXAN_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1179"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786895_0_0_7"/>
    <dbReference type="OMA" id="KGGVECT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="403" mass="43805" checksum="DED86A3738CCC1FB" modified="2006-07-11" version="1">MSSSKSAASAAASLRLPGTQPLASTSHSCPVVSFEILPSSGVLSRALPRVWLHVTPWSTQRLIGARLGLPSTLPSKMTPSQTDAPHAPSTPAAAPSAITRLARTLRGLPPAERWWGPGCAGMAGWLKRAAQSLPPEDLTPRFHALLARVRQGLPVLPQEAQRHQYVLVRGMLGDELPGYLLDNVQRLERRGLSVREAAVDTEGLLANNVAVLREVLRDAEYFGRSVVMVGHSKGGVECTATLALYPELRHVVRAVVTLQAPYGGSSIAHDLATTPQLRRLIDFAFPLLFHGVSRSVEELSYPQRQAFIQQHPYPADIPTVSLATSRLSRTSTLYPLQRYLHERYGYQSDGMVTAVDAEVPGARVVRLHDMDHAEAALRGLPGLVRYHPGDLTEVMVALALEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDJ8</accession>
    <name>Q1DDJ8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sdeK</name>
        <name evidence="7" type="ORF">MXAN_1014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574809">
            <id>Q1DDJ8</id>
        </interactant>
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
            <label>MXAN_2606</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1DDJ8">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1014"/>
    <dbReference type="EnsemblBacteria" id="ABF87906">
        <property type="protein sequence ID" value="ABF87906"/>
        <property type="gene ID" value="MXAN_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1014"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="FECVSAN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="148"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="283"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="55682" checksum="CC77A688B984B124" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDU5</accession>
    <name>KYNU_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kynureninase</fullName>
            <ecNumber evidence="1">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynU</name>
        <name type="ordered locus">MXAN_0917</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the kynureninase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551038.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDU5"/>
    <dbReference type="SMR" id="Q1DDU5"/>
    <dbReference type="STRING" id="246197.MXAN_0917"/>
    <dbReference type="EnsemblBacteria" id="ABF87345">
        <property type="protein sequence ID" value="ABF87345"/>
        <property type="gene ID" value="MXAN_0917"/>
    </dbReference>
    <dbReference type="GeneID" id="41358376"/>
    <dbReference type="KEGG" id="mxa:MXAN_0917"/>
    <dbReference type="eggNOG" id="COG3844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_4_0_7"/>
    <dbReference type="OMA" id="TFPTDGY"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061981">
        <property type="term" value="F:3-hydroxykynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
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        <property type="entry name" value="SSF53383"/>
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        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
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        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
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        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <sequence length="426" mass="47760" checksum="9F8B6DCA33680072" modified="2006-07-11" version="1">MTTPYLFEDSESFARKLDAEDALRGYRDAFHFPPGPDGKPVVYLAGNSLGLQPRNAARYIQEELEDWARLGVEGHHHGRHPWLHYHELVTEHAARLVGAKPLEVVVMNTLSVNLHLMMVSFYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGYDAREAVLELKPREGEETLRTEDILETIERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCFVGFDLAHGAGNLRLSLHDDGPDFAVWCSYKYLNAGPGALGGVFVHERHAHTKDLPRFEGWWGHDKQTRFQMGPTFSALPGAEGWQLSNPPIFQLAALRASLELFDQAGMAALRAKSERLTGYLEFLLDRLPEGFVRITTPRDVKQRGAQLSLRFRGEPQGLLKRLGDAGIICDFRKPDIIRAAPAPLYNSFTDVYRFVKTLEGHARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE12</accession>
    <name>Q1DE12_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0849"/>
    <dbReference type="EnsemblBacteria" id="ABF88074">
        <property type="protein sequence ID" value="ABF88074"/>
        <property type="gene ID" value="MXAN_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0849"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773198_0_0_7"/>
    <dbReference type="OMA" id="GFISFPC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="40676" checksum="A17B822E53259D9F" modified="2006-07-11" version="1">MSAWGARLSIAGRGPCVAGDRRTDGARQSRPRCSLSVAGNGTARRSMVSNAHGELSLAPPAGAVGAAAPQRVLKRWMVVGLRPVFALAGVGTLALLVHKAGPRELGAVLSGAAPWLPWVVLLELGRQCMDGLATRRAYGPGAGRVPWRVLARAQLIGTAVSSMAPAGRAAAEATKAALLSPYMGGGTATAAAATSQAASLAAGGFISFPCALASYMLTGMSLFTMLMLAHGGLLVLVSVGVRACMRAKRPGAWLVCRFSRWALHAEQFKASARCGSLLPWSPMLAFLCSRLFQVAQYGVLTYAVGIDTSLVQAFFAQGLYLCALAVGSLVPGQVGVSDGAFALAAGVLDTTAARAMSVALLGHLVQLLFVLVGALIPLVWRIRAPLPVAPAPACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE86</accession>
    <name>Q1DE86_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF87332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF87332">
        <property type="protein sequence ID" value="ABF87332"/>
        <property type="gene ID" value="MXAN_0771"/>
    </dbReference>
    <dbReference type="GeneID" id="41358240"/>
    <dbReference type="KEGG" id="mxa:MXAN_0771"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="FTFDPIY"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="321"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="521" mass="54335" checksum="98DE62285E308530" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB8</accession>
    <name>Q1DEB8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550865.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0739"/>
    <dbReference type="EnsemblBacteria" id="ABF87739">
        <property type="protein sequence ID" value="ABF87739"/>
        <property type="gene ID" value="MXAN_0739"/>
    </dbReference>
    <dbReference type="GeneID" id="41358210"/>
    <dbReference type="KEGG" id="mxa:MXAN_0739"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506067_0_0_7"/>
    <dbReference type="OMA" id="HMVAMAG"/>
    <dbReference type="OrthoDB" id="296539at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="512" mass="55034" checksum="BFCAED69EC3185B7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE5</accession>
    <name>Q1DEE5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550838.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0710"/>
    <dbReference type="EnsemblBacteria" id="ABF86889">
        <property type="protein sequence ID" value="ABF86889"/>
        <property type="gene ID" value="MXAN_0710"/>
    </dbReference>
    <dbReference type="GeneID" id="41358183"/>
    <dbReference type="KEGG" id="mxa:MXAN_0710"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="ADWRMPV"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13643" checksum="227493B795202D5F" modified="2006-07-11" version="1">METVLVVDDEQGILEALADLLREEGYRVLTASHGREALERMAELRPDLVLTDWMMPVLDGPALIERIRAEPAYKDVSLMGMSAVDVSALRHRYPGMPFLQKPFDIHALMRQVRKALDGKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF6</accession>
    <name>Q1DEF6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0699"/>
    <dbReference type="EnsemblBacteria" id="ABF88456">
        <property type="protein sequence ID" value="ABF88456"/>
        <property type="gene ID" value="MXAN_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0699"/>
    <dbReference type="eggNOG" id="COG3662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039076_1_0_7"/>
    <dbReference type="OMA" id="LGRHMGI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="entry name" value="PTHR36124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="104"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="41080" checksum="D36B9E3BC8FBC90F" modified="2006-07-11" version="1">MRAAPWSGARDGRRRKGANPGASVSNHAGKDPTRRQRARQALSGLDSAFAFTEERWMNRFALRDLTDRLDAQTQHEDIVRILATREFPWDVEQALSFALFRTYAVPSIGVLLHDTDEFTQRTQKRYDDTVLILDTILEHGMASQEGRSAFRRMNQMHGAYDISNDDMRYVLSTFVVMPVRWIADFGWRPFTPHEVTGWTNYYRAVGRHMGIQDIPETYEAFTSLMDGYEATHFAFDARSKAVADATLELLTTFPPTNLAPKRLVTLFARTLMEDALLDAFHYPHPSSLSRKVFRLALKARGTFVRYALSPKKEPAYARQRANIRSYPDGYAVESLGTFPRTCPVKHGAAAEGSPQRAPSKGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEN0</accession>
    <name>Q1DEN0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550756.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0625"/>
    <dbReference type="EnsemblBacteria" id="ABF90482">
        <property type="protein sequence ID" value="ABF90482"/>
        <property type="gene ID" value="MXAN_0625"/>
    </dbReference>
    <dbReference type="GeneID" id="41358103"/>
    <dbReference type="KEGG" id="mxa:MXAN_0625"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_7"/>
    <dbReference type="OMA" id="GKWTNCG"/>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="16"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="479" mass="52664" checksum="AF0C5E4BA75B6672" modified="2006-07-11" version="1">MRVVKLEEARMPDGVQEAFDRLHAHRWEVARRGMKERLARLEQFKTLLVARREALAEALHADFRKPRAEVEATEVLPVLMELASIQKHLKTWMKPRKVSTPLLLTGTSSLVQYEPRGVVLVMAPWNYPFHLLVSPLVAAVAAGNAVLCKPSEKTPNTARFIAELVKDVFPPEEVAVVEGGPEVGEALLRLPFDHIFFTGGARVGRRVMEAAAKHLASVTLELGGKSPVIVDETADVAAAAERVVWGKFLNGGQTCIAPDHVWVHASKEEALLEAMKEALERFYGRTEEARRASLDLCRMVDDSAFTRVRQLMDRTVEAGARVVVGGGVGAESRYIAPTVLADVTPDTPIMAEEIFGPVLPVLRFESLDEVVSHVREDGKPLALYVFSNDEATVERLLRETRAGGTCINTVVLHNVNPNLPFGGVGASGVGAYHGETGFRTFSHERAVLRQGRTSLVHLFFPPFTGKAQKLARLAGRLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ8</accession>
    <name>Q1DEQ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycine betaine/L-proline ABC transporter, permease and substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0597</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0597"/>
    <dbReference type="EnsemblBacteria" id="ABF89594">
        <property type="protein sequence ID" value="ABF89594"/>
        <property type="gene ID" value="MXAN_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0597"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577198_0_0_7"/>
    <dbReference type="OMA" id="FPRYDAV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13607">
        <property type="entry name" value="PBP2_AfProX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041894">
        <property type="entry name" value="PBP2_ProX-like"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="297"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="498" mass="53066" checksum="D1CFE171321012E7" modified="2006-07-11" version="1">MLLLVGACGGASSSGDGVPQVRVGSKKFTESVILGEAVTQLARSTGARVTHRRELGGTAVLWEALRRGELDVYPEYTGTLRQELLSGRHLPDDAALRAALAESGLRMSEPLGFNNTYALGMKEAEAERLGIRRISDLRAHPSLRFGFSNEFMDRADGWPALRDSYRLPQRDVRGLDHDLAYRGMESGSLQLTDLYSTDAEIEAYGLRVLEDDLRHFPAYDAVLLYRDDLEARAPEALAAMLRLEGHVSEADMVKLNALARLERVSEGRVASGFLATALGVTSEVRGDGLASRVWKRTREHLFLVGVSLLAAMALAVPLGVLAARRPRLGRGVLGLTGVIQTVPSLALLVVMIPLLGIGSRPAIAALFLYSLLPIVRNTAAGLAGIPPEVRESAEALGLPALARLWRIELPMAAPSILAGIQTAAVINVGTATLGALVGAGGYGQPILTGIRLDDVRLILEGAIPAAALALLASGLFDAVERVVVPRGLRLGTAVRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEY1</accession>
    <name>Q1DEY1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Big_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0523"/>
    <dbReference type="EnsemblBacteria" id="ABF92036">
        <property type="protein sequence ID" value="ABF92036"/>
        <property type="gene ID" value="MXAN_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0523"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430733_0_0_7"/>
    <dbReference type="OMA" id="ETHWVES"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="140"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="626" mass="67235" checksum="E61AACC0404748A0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF19</accession>
    <name>Q1DF19_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90466">
        <property type="protein sequence ID" value="ABF90466"/>
        <property type="gene ID" value="MXAN_0484"/>
    </dbReference>
    <dbReference type="GeneID" id="41357976"/>
    <dbReference type="KEGG" id="mxa:MXAN_0484"/>
    <dbReference type="HOGENOM" id="CLU_091669_0_0_7"/>
    <dbReference type="OMA" id="RIRCIDD"/>
    <dbReference type="OrthoDB" id="1574482at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="21025" checksum="090A78E6CC5D29B3" modified="2006-07-11" version="1">MPKRYFRLKEDMQAENWDLGDPLDEKGQEVDDPYLFAAGQPVRVAGRLTIPVDAPGRRLDFGTAGIGAAPIVHVRVATLFAELAPDDVQLIPVDIQGHPDQYLILVATKRIRCIDDEACEEVRYWKPEHGQPERIGDYKSVMGLRIDASKVGAAKVFRTEGWDIALIVSEDIKKALERAKATGAKFTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFD7</accession>
    <name>Q1DFD7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pilus biogenesis operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0362"/>
    <dbReference type="EnsemblBacteria" id="ABF86485">
        <property type="protein sequence ID" value="ABF86485"/>
        <property type="gene ID" value="MXAN_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0362"/>
    <dbReference type="eggNOG" id="COG3419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253163_0_0_7"/>
    <dbReference type="OMA" id="VWGVNET"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025193">
        <property type="entry name" value="DUF4114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13448">
        <property type="entry name" value="DUF4114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188480" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4114" evidence="2">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1419" mass="154653" checksum="EB03FD0BA4038B14" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK9</accession>
    <name>Q1DFK9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550428.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0284"/>
    <dbReference type="EnsemblBacteria" id="ABF87016">
        <property type="protein sequence ID" value="ABF87016"/>
        <property type="gene ID" value="MXAN_0284"/>
    </dbReference>
    <dbReference type="GeneID" id="41357784"/>
    <dbReference type="KEGG" id="mxa:MXAN_0284"/>
    <dbReference type="eggNOG" id="ENOG5031TXN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112468_0_0_7"/>
    <dbReference type="OMA" id="VMGLIQE"/>
    <dbReference type="OrthoDB" id="1728259at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045506">
        <property type="entry name" value="DUF6484"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20093">
        <property type="entry name" value="DUF6484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6484" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="18090" checksum="F20505F79C5CD346" modified="2006-07-11" version="1">MSESPDSKSLASGAQSQEPILGSRAGSLVGFDASGAVLVDFPGNTSGPVAARLAVVVEPKALQAAVAQRQKAVLLFENGDARLPFVMGLIQEPSATPLLDALLESPPPEAALRPTEAHVDGKRVVIEGQDEVVLKCGEASITLRRNGKVIVKGTYLESRASGTHRIKGGTVEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB1</accession>
    <name>Q1DGB1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550178.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0029"/>
    <dbReference type="EnsemblBacteria" id="ABF88713">
        <property type="protein sequence ID" value="ABF88713"/>
        <property type="gene ID" value="MXAN_0029"/>
    </dbReference>
    <dbReference type="GeneID" id="41357538"/>
    <dbReference type="KEGG" id="mxa:MXAN_0029"/>
    <dbReference type="eggNOG" id="COG5581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023735_0_0_7"/>
    <dbReference type="OMA" id="RGYEPTQ"/>
    <dbReference type="OrthoDB" id="71760at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="693" mass="77335" checksum="DA6B5E327E32CA2D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-03-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>P24220</accession>
    <accession>Q1CZX6</accession>
    <name>PYRF_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber>4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>OMP decarboxylase</fullName>
            <shortName>OMPDCase</shortName>
            <shortName>OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pyrF</name>
        <name type="synonym">uraA</name>
        <name type="ordered locus">MXAN_5910</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="819" last="824">
            <title>The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family.</title>
            <authorList>
                <person name="Kimsey H.H."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="1730672"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23"/>
    <dbReference type="EMBL" id="M79324">
        <property type="protein sequence ID" value="AAA25401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B41768">
        <property type="entry name" value="B41768"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555861.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P24220"/>
    <dbReference type="SMR" id="P24220"/>
    <dbReference type="STRING" id="246197.MXAN_5910"/>
    <dbReference type="EnsemblBacteria" id="ABF86406">
        <property type="protein sequence ID" value="ABF86406"/>
        <property type="gene ID" value="MXAN_5910"/>
    </dbReference>
    <dbReference type="GeneID" id="41363148"/>
    <dbReference type="KEGG" id="mxa:MXAN_5910"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060704_0_0_7"/>
    <dbReference type="OMA" id="QSAFFER"/>
    <dbReference type="OrthoDB" id="1181405at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000134632" description="Orotidine 5'-phosphate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="288" mass="30468" checksum="341E002170214DF9" modified="1992-03-01" version="1">MTTPQPFAHRFSQLAEQRSPFCLGIDPSRDLLTRWGLPDNARGLRDFCERVADAAGSSVAVVKPQSAFFERHGPEGLQVLQELMRRFKSVGTLTLLDVKRGDIGSTMEAYAETVFGEGSAYEADAATFTAYLGLGALLKTLERARASGAAAFLVVRSSNPEGTSLQMSRGEDGRTVAEALADGLRAFNEKPGQDAAPVAGAVMGATLPDSDRGVIERLGGALLLTPGIGAQGAGFDDLKRLFAGREAQVIPTATRSVLEAGPDTAALRQALERHLAPARAFRATARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH2</accession>
    <name>Q1CVH2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptide peptidase SppA, 67K type</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sppA</name>
        <name evidence="6" type="ORF">MXAN_7498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557400.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7498"/>
    <dbReference type="EnsemblBacteria" id="ABF91611">
        <property type="protein sequence ID" value="ABF91611"/>
        <property type="gene ID" value="MXAN_7498"/>
    </dbReference>
    <dbReference type="GeneID" id="41364632"/>
    <dbReference type="KEGG" id="mxa:MXAN_7498"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008856_1_0_7"/>
    <dbReference type="OMA" id="DPKGQYL"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="197"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="448"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="680" mass="72824" checksum="C09FC1313D4CEFBA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH6</accession>
    <name>MNMG_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">MXAN_7494</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557396.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CVH6"/>
    <dbReference type="SMR" id="Q1CVH6"/>
    <dbReference type="STRING" id="246197.MXAN_7494"/>
    <dbReference type="EnsemblBacteria" id="ABF88025">
        <property type="protein sequence ID" value="ABF88025"/>
        <property type="gene ID" value="MXAN_7494"/>
    </dbReference>
    <dbReference type="GeneID" id="41364627"/>
    <dbReference type="KEGG" id="mxa:MXAN_7494"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_7"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000345303" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="615" mass="66133" checksum="EDDAE87E73286E26" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW63</accession>
    <name>Q1CW63_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557166.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7247"/>
    <dbReference type="EnsemblBacteria" id="ABF92920">
        <property type="protein sequence ID" value="ABF92920"/>
        <property type="gene ID" value="MXAN_7247"/>
    </dbReference>
    <dbReference type="GeneID" id="41364413"/>
    <dbReference type="KEGG" id="mxa:MXAN_7247"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056998_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="29037" checksum="E40B5B7D1287AA1B" modified="2006-07-11" version="1">MRDGLEVAVSRVLKASTESSHRLGMENQQVLGQLERSVESVVERFQQVLAGMDASTQRLVQSASHSAEHIHQQAGTQSILLSQQVEALRSAANVDMNSFQSRSEEFSKVMGTTQDGLRQLTEQLRNTASQLASATRGAGETHDKAKGAAVQLEQVSRQLIETAKEFNQVTQGRREVVKVEENLLNAQRQAIERIQPVLNGLTRSYEESVEKQAQALSGQWTKVMQDLRGVVEKTSGELAQGVDDLSETVQELSKALKTQVRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWA1</accession>
    <name>Q1CWA1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S8A (Subtilisin) subfamily</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7209"/>
    <dbReference type="EnsemblBacteria" id="ABF87220">
        <property type="protein sequence ID" value="ABF87220"/>
        <property type="gene ID" value="MXAN_7209"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7209"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_3_7"/>
    <dbReference type="OMA" id="YPAGMAT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="168"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="499"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="571" mass="59579" checksum="DD076166987A2EE0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWZ5</accession>
    <name>Q1CWZ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556884.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6963"/>
    <dbReference type="EnsemblBacteria" id="ABF85986">
        <property type="protein sequence ID" value="ABF85986"/>
        <property type="gene ID" value="MXAN_6963"/>
    </dbReference>
    <dbReference type="GeneID" id="41364141"/>
    <dbReference type="KEGG" id="mxa:MXAN_6963"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_4_7"/>
    <dbReference type="OMA" id="DEEYGVE"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="148" mass="15755" checksum="78A0A998904B0D6F" modified="2006-07-11" version="1">MSVLHVVFKVDGAEYVLPAADVLQMESFTGATPVPGAAPHVAGLVQVRGRVIPVVDARLRFGLPPVERTLDSRVVVAQLGSRVVGLVVDSAREVLKLDPQQLKPPPPLVVEGARGFVKAVAQVGPRLVMLIDFPRVIGEETLDGDGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX09</accession>
    <name>Q1CX09_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556870.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6949"/>
    <dbReference type="EnsemblBacteria" id="ABF87567">
        <property type="protein sequence ID" value="ABF87567"/>
        <property type="gene ID" value="MXAN_6949"/>
    </dbReference>
    <dbReference type="GeneID" id="41364127"/>
    <dbReference type="KEGG" id="mxa:MXAN_6949"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_4_0_7"/>
    <dbReference type="OMA" id="FHESPTS"/>
    <dbReference type="OrthoDB" id="1654578at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="21157" checksum="8CF5BE17D6671749" modified="2006-07-11" version="1">MPDVDWEATRARLARLADLVKEQGTLSPEEATALLEARARALSREPRPQVDPGTLREVVRFKAAGQRYALESRFVLEVVRAPELVTLPGAPPALRGLTLMHGEVLPVVELAPLFGRAPSDAAGPVLVVGVGRAELGVRTEEVEEVTVLAGSELLAPPTSLNDDAGHLVSAADREGTLVLEGEALLGDSRLMFDMSGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX26</accession>
    <name>Q1CX26_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556853.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6933"/>
    <dbReference type="EnsemblBacteria" id="ABF89580">
        <property type="protein sequence ID" value="ABF89580"/>
        <property type="gene ID" value="MXAN_6933"/>
    </dbReference>
    <dbReference type="GeneID" id="41364114"/>
    <dbReference type="KEGG" id="mxa:MXAN_6933"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077145_0_0_7"/>
    <dbReference type="OMA" id="PRNSWVV"/>
    <dbReference type="OrthoDB" id="2040599at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="34301" checksum="292B88856B47D1A7" modified="2006-07-11" version="1">MALVAARPTLMHDLMPFEPYDIDPNDPRAPPQETWDALSSEERQRIVDSLPSEFPVSEANPPEGDFHFEAKTRAREVLGSFFSRIGRKVYLGSELPVYYPGESMFAPDVMAVVDVEPHARMRWVVSAEGKGLDFALEVHVAGERRKDLERNVERFARLGIREYFVFDRGRLRLSGWRLDEGRRVYRPILPQHGLYPSEVLGLDLQVDDERLRFYLGGAALPEAPELIARLEHMVERVEASRAELVQQLAEESRLRAEESRLRAEESRLLELETQRREDAERQLAEARAEIARLRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX62</accession>
    <name>Q1CX62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89053">
        <property type="protein sequence ID" value="ABF89053"/>
        <property type="gene ID" value="MXAN_6897"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6897"/>
    <dbReference type="HOGENOM" id="CLU_1675990_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="157" mass="17089" checksum="29BAEC08B0C7DB90" modified="2006-07-11" version="1">MPGLRRPRSHSIVFAEQCSTPRQSPLSEQAVEQVLVAVSQVPPQGQWASAKHSTQEVPSQTVPGSHVTAHAPEFSHVRVVGLHTPLPQSPSSVQPTQVLPCAVPLERQKGVSPSQAPQRGPQCLSVVQDAHSPLRQNWPSPHSKSLRHWTQTSPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA1</accession>
    <name>Q1CXA1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MXAN_6855</name>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        </reaction>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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            <end position="58"/>
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            <end position="125"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="287"/>
            <end position="307"/>
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    </feature>
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        </location>
    </feature>
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            <end position="445"/>
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            <end position="675"/>
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        <location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXP3</accession>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXS7</accession>
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            <fullName evidence="2">DUF6531 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="ABF90977"/>
        <property type="gene ID" value="MXAN_6679"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_225642_0_0_7"/>
    <dbReference type="OMA" id="LPAWDFV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="880"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2963"/>
            <end position="3009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2973"/>
            <end position="3000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="3146" mass="340369" checksum="9E283A35BF1C2C9D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXU9</accession>
    <name>Q1CXU9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556582.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6657"/>
    <dbReference type="EnsemblBacteria" id="ABF91328">
        <property type="protein sequence ID" value="ABF91328"/>
        <property type="gene ID" value="MXAN_6657"/>
    </dbReference>
    <dbReference type="GeneID" id="41363855"/>
    <dbReference type="KEGG" id="mxa:MXAN_6657"/>
    <dbReference type="eggNOG" id="COG3863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104117_0_0_7"/>
    <dbReference type="OMA" id="CSELIWK"/>
    <dbReference type="OrthoDB" id="1342393at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188161" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="22887" checksum="328A62ED911CF32D" modified="2006-07-11" version="1">MRWMVMLMVWFGAHNAVAAPHEGLEARLQTGDIVLHTSRSSQSQAIQKATQSPLSHVGMVEVTEQGAWVVEAVQPVQRIRFSKWKARGAKGGILVLRPRELSDAQRQQAVAAAKAHLGKPYDWLFGWGDDAMYCSELVRKAYAQGAGLEYGKMERLDSLRVKGLEQQLRERYGKRVPLDLELVTPASIAADVRLEVVHSDFPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY00</accession>
    <name>Q1CY00_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6605"/>
    <dbReference type="EnsemblBacteria" id="ABF89791">
        <property type="protein sequence ID" value="ABF89791"/>
        <property type="gene ID" value="MXAN_6605"/>
    </dbReference>
    <dbReference type="GeneID" id="41363803"/>
    <dbReference type="KEGG" id="mxa:MXAN_6605"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277050_0_0_7"/>
    <dbReference type="OMA" id="HISANEY"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="5">
        <location>
            <begin position="37"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1146" mass="120158" checksum="47F0301E7755418D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY92</accession>
    <name>Q1CY92_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556439.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6508"/>
    <dbReference type="EnsemblBacteria" id="ABF89587">
        <property type="protein sequence ID" value="ABF89587"/>
        <property type="gene ID" value="MXAN_6508"/>
    </dbReference>
    <dbReference type="GeneID" id="41363716"/>
    <dbReference type="KEGG" id="mxa:MXAN_6508"/>
    <dbReference type="eggNOG" id="COG2966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637489_0_0_7"/>
    <dbReference type="OMA" id="PMTVIMP"/>
    <dbReference type="OrthoDB" id="667657at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="44813" checksum="5F018327B9F0128B" modified="2006-07-11" version="1">MKREHGLGTGGDEEAASRFLLDLARALHLAYQPSLLVESRVRRAARAWGLSTEVFTVQSLAMTQVVAPRRSPADFARLPFNPHWNLGRAARLLQLTDDIAAGGVGLPEARARLDRIVAERSPYPKWLVLLAYGVYGAAAAARVGGAWWEMFAALLVGAIAGVIHFGTLVSQRVDLQKSFLAAFLGTLVAFGLRFVLPPFDVVQALFGGAVLLVPAMVVTLGSLELASESVEAGMTRLVYGLLRFLMIGVGIVAATTLWGFLLPVPEYSDVHVLSPWVTFLLLAVGGVALAVCMAGRRRDLVGIVGGVLIAYGTQAGMKAVLGEQGSPMVAAFVLGVAGLLYGRGGLRMPMTVIMPGLLQLAPGFMGTQAIIALLGMGRPGAEDARPFDVLMVALQLVLGLVFATLVVPPRIPVDGDDTAPSGSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYT1</accession>
    <name>Q1CYT1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6317"/>
    <dbReference type="EnsemblBacteria" id="ABF88719">
        <property type="protein sequence ID" value="ABF88719"/>
        <property type="gene ID" value="MXAN_6317"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6317"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="EFVWARQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="42722" checksum="8C156EE60BE08D37" modified="2006-07-11" version="1">MLGPGPEARGHILPSTLCACFDSLRAVPPAAKPVRHRKIGAYRVLGELGRGGMALVYRGLHEMLQREVAIKELLPDGQRDRETLSRFRREALALAAFRHQNIVTLYDMVEKGESLFMVMELVDGPTLHTLIKEGPLPADVTGVIAARIASALDHAHFRHIIHRDLKPANVMLTKSGEVKLMDFGIAKDVGMEALTQQGMAVGTPSYMSPEQVTGVPVDGRTDIFSLGVLLYEALSGARPFHGKTAGEVFAKIRDGKYTPLSKVAPNVPAPLVRIIQRAMEVKPEDRFPDAAAMRRELDVFLAQEVQVSHAALLVAFLRHRQKLTETEAQQLMRPHELDAAVEVFDTGRSRQGGKLRWALAAAIALMTAAGTGLYFTQAQWAPLVEQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ02</accession>
    <name>Q1CZ02_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89982">
        <property type="protein sequence ID" value="ABF89982"/>
        <property type="gene ID" value="MXAN_6242"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6242"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355943_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="788" mass="86159" checksum="1A887118BB914567" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ51</accession>
    <name>Q1CZ51_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556135.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6191"/>
    <dbReference type="EnsemblBacteria" id="ABF92163">
        <property type="protein sequence ID" value="ABF92163"/>
        <property type="gene ID" value="MXAN_6191"/>
    </dbReference>
    <dbReference type="GeneID" id="41363420"/>
    <dbReference type="KEGG" id="mxa:MXAN_6191"/>
    <dbReference type="HOGENOM" id="CLU_2955758_0_0_7"/>
    <dbReference type="OMA" id="GSWRNIY"/>
    <dbReference type="OrthoDB" id="2063261at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="59" mass="6462" checksum="BFFD690EE0F2CE5F" modified="2006-07-11" version="1">MSTAPHLNPSEPSAEVPAPRPELDDAPPLLGSWRNIYILVLGTFVLFLALGWVLTEVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ70</accession>
    <name>Q1CZ70_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92720">
        <property type="protein sequence ID" value="ABF92720"/>
        <property type="gene ID" value="MXAN_6172"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6172"/>
    <dbReference type="HOGENOM" id="CLU_1401178_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21332" checksum="D44DE1909EDD1254" modified="2006-07-11" version="1">MTPREDDMKAMTRYLVLFSMLAVGCGDSSDGDGDSALKCDAIGWCTSWESDQAPVTDAPALKGGSVPEGLYRLERGSEDARALLFKGKSVLKVGGSWGNILGTWKVDGNHLVITTASSCYGTREDAFNETFRYAFAVKGDTLYLHEDEFEDMPIMAWRKVDSLCQENASFNCKVSNCTCKYVANSSFDTSERCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ76</accession>
    <name>Q1CZ76_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556110.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6166"/>
    <dbReference type="EnsemblBacteria" id="ABF86771">
        <property type="protein sequence ID" value="ABF86771"/>
        <property type="gene ID" value="MXAN_6166"/>
    </dbReference>
    <dbReference type="GeneID" id="41363396"/>
    <dbReference type="KEGG" id="mxa:MXAN_6166"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_3_0_7"/>
    <dbReference type="OMA" id="DALQPCG"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="31779" checksum="6A0C58D329DAE83B" modified="2006-07-11" version="1">MPLHIQTPYIRSQVASRRLGKDVLFKLEAMQPSGSFKLRGVGAVCDARRAAGSRRFVSSSGGNAGIAVAYAGRELGVPVLVVVPESTSARARDLIRLEGAELIVHGASWAEANMFAQSVLSPHDAFVHPFDEPELWQGHSTMIDEMAAAGPKPDAVVLAVGGGGLLCGVLEGLARNGWGDVPVVAAETQGADCYARSIAQGRPVELPAITSVATSLGAKRPCDAAVEWATRHTVENIVVSDAAAVAASLRFLDEHRILVEPACGAALAALDAASTVLAAASRIAVIVCGGVTATVEYLQALSSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB7</accession>
    <name>Q1CZB7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556070.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6121"/>
    <dbReference type="EnsemblBacteria" id="ABF90395">
        <property type="protein sequence ID" value="ABF90395"/>
        <property type="gene ID" value="MXAN_6121"/>
    </dbReference>
    <dbReference type="GeneID" id="41363355"/>
    <dbReference type="KEGG" id="mxa:MXAN_6121"/>
    <dbReference type="eggNOG" id="ENOG5030IHG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025691_0_0_7"/>
    <dbReference type="OMA" id="FALDDWS"/>
    <dbReference type="OrthoDB" id="1101714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="34494" checksum="4424721F0E69BC90" modified="2006-07-11" version="1">MIGIHDGRHRSGEPADRVPSAHARPRGPVRIPEPMRLKQSFLLPLAVLSLGVLPACSDDGDDPPPGNDAGTDAGTHAGADSGTDAGDDNPGPSTEPGTCPSNALLCELFDSGNDTNGWSASAENSSLQVDSTRTRNGPGALHVLTEDGHDERQRPGKAIAQWQKSIPAFETRLFVRAHVYMRSLPGVFGQMGTFFVLSNFGADFGGFELQVMQDSGFALDDWSFREGQGWNRQPEPVRLGMEAGRWVCLEWEVRRDSPSSTHGNTRVYVDGTLAHDFTNIGMRAFNNFSVGYGFVHPLGASGSETWIDNVVVSTQRVGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB8</accession>
    <name>Q1CZB8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2263 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556069.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6120"/>
    <dbReference type="EnsemblBacteria" id="ABF86196">
        <property type="protein sequence ID" value="ABF86196"/>
        <property type="gene ID" value="MXAN_6120"/>
    </dbReference>
    <dbReference type="GeneID" id="41363354"/>
    <dbReference type="KEGG" id="mxa:MXAN_6120"/>
    <dbReference type="eggNOG" id="COG4295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_4_1_7"/>
    <dbReference type="OMA" id="AHRDPFY"/>
    <dbReference type="OrthoDB" id="1481953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29023" checksum="874D29D6CADC1619" modified="2006-07-11" version="1">MSLKGIGQETVDIIERGQYLAPSGQCVQLGEAVERAVSGTELYRPGDFSRLSFPTAANPSAPRIEVTAEKTGAAARRLVEAGASHVAALNFASAKNPGGGFLGGAKAQEEDLARCSALYTCLLTQREYYDVNRAEPSPLYTDHLIYSPDVPFFRDEGLTLLEQPFHVSILTAPAPNAGVAQSRDRGMGGRIRKVLDERALKVLRVAAHHGHRTLVLGAWGCGVFRNNPVEVAEAFALGLGSLPGAFDRVVFAVYERGGDGPNLRAFQARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D041</accession>
    <name>Q1D041_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555796.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5845"/>
    <dbReference type="EnsemblBacteria" id="ABF87914">
        <property type="protein sequence ID" value="ABF87914"/>
        <property type="gene ID" value="MXAN_5845"/>
    </dbReference>
    <dbReference type="GeneID" id="41363083"/>
    <dbReference type="KEGG" id="mxa:MXAN_5845"/>
    <dbReference type="eggNOG" id="COG3678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782837_0_0_7"/>
    <dbReference type="OMA" id="WRGHGHD"/>
    <dbReference type="OrthoDB" id="1822070at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025961">
        <property type="entry name" value="Metal_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13801">
        <property type="entry name" value="Metal_resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="170" mass="19027" checksum="AADD4739445BBA44" modified="2006-07-11" version="1">MPTVAARGGDFTWSRPRSTQEKAMMKRFAVVGSAMLAVALLSGFALRGGPRWGKDPERVKQLVTWKLDDKLDTLDATESQRQSIHAVKDRLFSDGVQLMQEHRAVREEAFQQLASDTPDRQKLHALVDARIEAMRAFAHQATDAALEVHGTLTPQQRKALAEQFREHVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0E7</accession>
    <name>Q1D0E7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88179">
        <property type="protein sequence ID" value="ABF88179"/>
        <property type="gene ID" value="MXAN_5739"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5739"/>
    <dbReference type="HOGENOM" id="CLU_128161_0_0_7"/>
    <dbReference type="OMA" id="PCPVTFP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187958" evidence="2">
        <location>
            <begin position="32"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="19203" checksum="1FC2DBA919341E9D" modified="2006-07-11" version="1">MGEYPHPMHRALPTLALHLSVLSLTACSAKAPPRTEPVPPPPPAVKIPASCEQNQGGEYHHAGNPAFRYYGDDDGSTLSLAVVRAHDSAAVDAPDAGSPSIVLRRTPAGFVGETRATGFSGAGTPCPVTFPTEVVRCTDAGLTLRSAASTSIDEDCRTAPSGAPSVRLEQVLLRGPPDAGTSPDAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0F9</accession>
    <name>Q1D0F9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555678.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5726"/>
    <dbReference type="EnsemblBacteria" id="ABF93077">
        <property type="protein sequence ID" value="ABF93077"/>
        <property type="gene ID" value="MXAN_5726"/>
    </dbReference>
    <dbReference type="GeneID" id="41362970"/>
    <dbReference type="KEGG" id="mxa:MXAN_5726"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077411_1_0_7"/>
    <dbReference type="OMA" id="PIHCDIH"/>
    <dbReference type="OrthoDB" id="1869568at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="29525" checksum="6076CCD8EDE759BD" modified="2006-07-11" version="1">MALAAMLHLKQLHAPVRPERVLRPSFVIVLCALTPACKESASPPPATTTSPAIAPAATNTKWGVIEGRVRLTGTPPAPARQPTIGTVVSVCGEETEERTLVVGSEGALAHTVVSLRDGHALPASARAAPEPVLDQKQCVYDPPVLAARTGSTLVIRNSDPLVHNVRAASGTNRAFFNVAMPLEGMMVKRRLPAEPGEVPIHCDIHPWMRARVRTFSHGYFATSGADGRFQLEVPEGTHTLVLWHERLPEQARTVTVRAGERVQVDAEWPVADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K2</accession>
    <name>Q1D0K2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555636.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5683"/>
    <dbReference type="EnsemblBacteria" id="ABF87717">
        <property type="protein sequence ID" value="ABF87717"/>
        <property type="gene ID" value="MXAN_5683"/>
    </dbReference>
    <dbReference type="GeneID" id="41362928"/>
    <dbReference type="KEGG" id="mxa:MXAN_5683"/>
    <dbReference type="eggNOG" id="COG3014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035715_3_0_7"/>
    <dbReference type="OMA" id="NDAFIDY"/>
    <dbReference type="OrthoDB" id="1203790at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="418" mass="45576" checksum="4AD44CF5D160E7B1" modified="2006-07-11" version="1">MSIHSRSPVRLSGWGALALASVLLLSSGCAGDYVARTRGVRSAYQQGDYSRALSSLEAAAKEGPEQDRLLVLMDKGMVLHAAGQWAESNAVLEEAERLSEQIDSVSVSEEAKTLVTNERQRTYRGEDFEKLMISVLQALNYAELGDDEAAMVEVRQVNERLEKMIAEEKKPYEQLAIARYLGGVIREDQRDWDSAYIDYAKAYEIAPREDALAEPLLRLAKKVGRDDMYAELLAKYPDVPHAPLAPDEGQLVVVVEAGLSPEKQRGSRDPGGGGDLIEVPTYRNRGLAPPVSVALEGQSQQAVTVTSLADVAVVHLNDRIGRMLAKQLAGVAVKAGVAAGVGALTKSDELGVLTFLVLNAMNAPDLRSWLSLPAEFQVARFRVPAGNHTVRVTSWGQVTEHPVEVKPGRVELLVLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N3</accession>
    <name>Q1D0N3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type III secretion lipoprotein, YscJ/FliF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_5651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YscJ lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555605.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5651"/>
    <dbReference type="EnsemblBacteria" id="ABF88690">
        <property type="protein sequence ID" value="ABF88690"/>
        <property type="gene ID" value="MXAN_5651"/>
    </dbReference>
    <dbReference type="GeneID" id="41362897"/>
    <dbReference type="KEGG" id="mxa:MXAN_5651"/>
    <dbReference type="eggNOG" id="COG4669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073268_0_1_7"/>
    <dbReference type="OMA" id="GRIQQMV"/>
    <dbReference type="OrthoDB" id="858412at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003282">
        <property type="entry name" value="T3SS_HrcJ/YscJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01338">
        <property type="entry name" value="TYPE3OMKPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="8 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="11">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF88690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="28637" checksum="6DF3B6181EF50B09" modified="2006-07-11" version="1">MRLHFRRAFFLVLLVSVTACRERIQHGLDERQANELQSVLVERGLDARKVPEAGKKPTWSIEVADEHASDAVRILSELGLPRPKEEVGCDVFGGGGLVRTPVEESVCRVRVMERSLEKTLQSVEGVLLARVHLVVPAPPRVGQAPGPSKASAMLRVAPGNAARVRQSSETLKVLLAGGVEGLSPEAVSLLVDEVSTRVEAPTEVGVSPLTRLRALLAVLGLMVTGLSVALVLVTLRMRHYRDRTPTPSAPPGPARPVLSPGPARKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q3</accession>
    <name>Q1D0Q3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555585.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5631"/>
    <dbReference type="EnsemblBacteria" id="ABF87171">
        <property type="protein sequence ID" value="ABF87171"/>
        <property type="gene ID" value="MXAN_5631"/>
    </dbReference>
    <dbReference type="GeneID" id="41362877"/>
    <dbReference type="KEGG" id="mxa:MXAN_5631"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_4_1_7"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="OrthoDB" id="1242215at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="27143" checksum="FE96644D8E243A80" modified="2006-07-11" version="1">MRQPTAVKNVLLLKAGEAAEAVRVSVGDYDRWFLQAIGLSGYRFDIVLAHRDAPLPTRADGYDAVMMTGSPLSVTALEPWMKRAADFMVEAGERGTPVLGVCFGQQLLAHAYGGRVSRNPQGRETGSVEVTLTEAGKQDPLFDGVPERFIAQATHEDIVSHLPDGAQVLAGNANTAAQALAFRPTVRGVQFYPEASVDTLRAVIEARWEGLERDSVARGAAPGEYVRQLLAGLTPSPAGRRILLNFLERFT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T2</accession>
    <name>MURB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="1">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murB</name>
        <name type="ordered locus">MXAN_5602</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555556.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0T2"/>
    <dbReference type="SMR" id="Q1D0T2"/>
    <dbReference type="STRING" id="246197.MXAN_5602"/>
    <dbReference type="EnsemblBacteria" id="ABF91276">
        <property type="protein sequence ID" value="ABF91276"/>
        <property type="gene ID" value="MXAN_5602"/>
    </dbReference>
    <dbReference type="GeneID" id="41362848"/>
    <dbReference type="KEGG" id="mxa:MXAN_5602"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_7"/>
    <dbReference type="OMA" id="KMNAGMK"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000332478" description="UDP-N-acetylenolpyruvoylglucosamine reductase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <sequence length="310" mass="31972" checksum="43F3A68B85D037BE" modified="2006-07-11" version="1">MVEAGVKTALAARVESLGGCEVKAGEPLAPLTSVRAGGAAEALVRPRSPDALVALLKLAREEGVPVSILGGGANTLVGDGGVPGLTLKLPGDLFPEVADVGPEEGRLTLGAGAAIVRLINVMRAHALVGAEFLAGIPGTLGGAVSMNAGTKNGEAFRVIEAVEVATADGVGWLTKAQVPYSYRHSELPPGGVVTRVRFALRKGDVVASKAVMDADLGYRKRTQPLSQPNFGSVFTNPPGDHAGRLIELAGLKGYSLGRAQVSTLHANWIVNLGGATARDVLGLVTLMQQRVLEQSGVDMKPEVKRLGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B4</accession>
    <name>Q1D1B4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555374.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5412"/>
    <dbReference type="EnsemblBacteria" id="ABF89638">
        <property type="protein sequence ID" value="ABF89638"/>
        <property type="gene ID" value="MXAN_5412"/>
    </dbReference>
    <dbReference type="GeneID" id="41362675"/>
    <dbReference type="KEGG" id="mxa:MXAN_5412"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440007_0_0_7"/>
    <dbReference type="OMA" id="HPFDSHP"/>
    <dbReference type="OrthoDB" id="130065at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="269"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="619" mass="68613" checksum="48EDCAA7A7E09868" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1K0</accession>
    <name>Q1D1K0_MYXXD</name>
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        <submittedName>
            <fullName evidence="4">Heat shock protein 70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92794">
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        <property type="gene ID" value="MXAN_5323"/>
    </dbReference>
    <dbReference type="GeneID" id="41362592"/>
    <dbReference type="KEGG" id="mxa:MXAN_5323"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013948_0_0_7"/>
    <dbReference type="OMA" id="QAAFYDW"/>
    <dbReference type="OrthoDB" id="155921at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="925" mass="100311" checksum="0443CD856880B5EA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V1</accession>
    <name>Q1D1V1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HhH-GPD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92367">
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        <property type="gene ID" value="MXAN_5220"/>
    </dbReference>
    <dbReference type="GeneID" id="41362502"/>
    <dbReference type="KEGG" id="mxa:MXAN_5220"/>
    <dbReference type="eggNOG" id="COG0122">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546081_0_0_7"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlkA_N"/>
    </dbReference>
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        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
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        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlkA_N" evidence="2">
        <location>
            <begin position="184"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="315"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="54792" checksum="EBF96F78E3CBCD4A" modified="2006-07-11" version="1">MRGAKSWQGLQLYTVGHSTRTLDELIALLRPFGVSTVVDIRTIPRSRHNPQFESEALRSALRRHHLRYVHLPALGGLRHARGDSPNTGWRNASFRGYADYMLTDAFESGLAELRELVAEGTVALMCAEAVPWRCHRSLVADALTVRGAQVEHITSRTRSTPHRMTDFAHVDGTRLTYPAGLGSSLDTRAPFHLEATVRVLQRRPTNLVDVWEGGRYLRALTVSDGFVLVEVSNQGTVDEPQVRFRVLDGDDSRGAHAEISRVLRRGLGLDVDPEPLDRLLQSERKLGPIVRALRGMRPPRFPSLFETFANVIPFQQVSLDAGVAVVRRLVARFGRFLPHEGQVRYAFPTAAALAEARLDAIRSCGLSARKAEALRAAAAAIQAGDVTEAMLSQMSSAEAMRMLTGLHGIGPWSAALVLLRGLGRLDVFPEGDVGVIRGLSGLMHVEPGPALERLIRRFGEQRGYLYFCSLGSALLARGLIHAADAGPRRSLLIAPESHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y0</accession>
    <name>Q1D1Y0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555161.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5190"/>
    <dbReference type="EnsemblBacteria" id="ABF88529">
        <property type="protein sequence ID" value="ABF88529"/>
        <property type="gene ID" value="MXAN_5190"/>
    </dbReference>
    <dbReference type="GeneID" id="41362472"/>
    <dbReference type="KEGG" id="mxa:MXAN_5190"/>
    <dbReference type="eggNOG" id="ENOG50336V8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1756889_0_0_7"/>
    <dbReference type="OMA" id="CGSEYQD"/>
    <dbReference type="OrthoDB" id="1598686at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="2">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="17417" checksum="5F0A0B49ABCBB701" modified="2006-07-11" version="1">MKYCARCGSEYQDGVNACADCPGNPLLVSAEEMRSRGLPLPHELDTRIFVRAGSAEDPFTAEVYAQLLQDANIPVLVRAGRSGVVDKLTTGNVLPWWEIHVPADQQVRAATLIEQERLRELATNDEAAAAAEAEERETESPAAEAKERETESPATPPPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y7</accession>
    <name>Q1D1Y7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555154.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5183"/>
    <dbReference type="EnsemblBacteria" id="ABF92858">
        <property type="protein sequence ID" value="ABF92858"/>
        <property type="gene ID" value="MXAN_5183"/>
    </dbReference>
    <dbReference type="GeneID" id="41362465"/>
    <dbReference type="KEGG" id="mxa:MXAN_5183"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599680_0_0_7"/>
    <dbReference type="OMA" id="FPELPWA"/>
    <dbReference type="OrthoDB" id="739702at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188138" evidence="1">
        <location>
            <begin position="21"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="456" mass="48386" checksum="245D7B716E876B49" modified="2006-07-11" version="1">MRLRSTLACLALLASASAQAAGRPRYGGELRVAHGGPPEVAEPALADTPLEATLLGLLSPPVCRATRDGGFEPALARELSRPTPQSLRITLPGPASATALARAWMRLASHDGASPYRALFHPLRGEARQVTPQGATLELTLAYPWPDLERALCHPALAPPASANALGPFTAAGRGALEAQTAWPQGRPYLDRLLLTSTDQRGLSRLWSSRQVQVELGVASETDTTAGDPLYATFLAFSPRRLPPDFRQAVESAIDREDLTRLFVQAPAQPMPHLLPPVMLDAPARSRPSAPSARPARTVTLRYDASVEDQRAVAERIQVKLHERGYTVALEALPRAALRARWAQGDFELMLHALLLPPIPGPALAVVLDAGGRKDLLGVELPAIGALASTAARDARARERALALAASVPLVPLYVQGLGMRFAPDVGGVMMDAQGLPSLDGLHVLPPEGTAMGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D202</accession>
    <name>Q1D202_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_5168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555139.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5168"/>
    <dbReference type="EnsemblBacteria" id="ABF91808">
        <property type="protein sequence ID" value="ABF91808"/>
        <property type="gene ID" value="MXAN_5168"/>
    </dbReference>
    <dbReference type="GeneID" id="41362451"/>
    <dbReference type="KEGG" id="mxa:MXAN_5168"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="EMPSNSH"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="301"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="484"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="712"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="807" mass="86167" checksum="B351C771616A40C2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D245</accession>
    <name>Q1D245_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator MrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mrpB</name>
        <name evidence="9" type="ORF">MXAN_5124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555098.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5124"/>
    <dbReference type="EnsemblBacteria" id="ABF87660">
        <property type="protein sequence ID" value="ABF87660"/>
        <property type="gene ID" value="MXAN_5124"/>
    </dbReference>
    <dbReference type="GeneID" id="41362408"/>
    <dbReference type="KEGG" id="mxa:MXAN_5124"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="IGINCSA"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
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        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="148"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="488" mass="54109" checksum="8A48E17D2B0699EA" modified="2006-07-11" version="1">METLLIVDDDVSLLETLKMHFEEIEQDGQPRYQVATATSAAAGLRAAQEAMPSVVILDMMLPDRTGLEIIEEMKGLCGDARIILVTAYHDMETTIRAMKAGAFDYIHKPFPDPAALDLVVERALEYRQLSRRADEVHRENAAARLGDIVGTSPLMQQLVKEIGKVTGSHATVLITGESGTGKELIARVIHNYSYDEPRPFIGINCSAIVDTLLESELFGHEKGAFTGATAGKPGKFELAEDGTVFLDEIGDMSLMLQAKLLRVLQEREFERVGGVKRIKLRARVIAATHRALVEEVEAGRFREDLYQRLKVITLQIPPLRERREDIPPLVKHLLERINEKVHKRVTRVPGEVMERLTRLPWRGNVRELENVLTRAVVLAPGDVLRGDDLPALESPLPSPEPGRATSAHHTASAMFAAPAEDDASLIPTLEEAERQLIARAMTVTKGHKGRTCQILGISRPTLERKLQKYGLAQSQSPQVHTFPVKDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R3</accession>
    <name>Q1D2R3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_4903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554884.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4903"/>
    <dbReference type="EnsemblBacteria" id="ABF92704">
        <property type="protein sequence ID" value="ABF92704"/>
        <property type="gene ID" value="MXAN_4903"/>
    </dbReference>
    <dbReference type="GeneID" id="41362192"/>
    <dbReference type="KEGG" id="mxa:MXAN_4903"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_7"/>
    <dbReference type="OMA" id="YLTMEDV"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="289"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF92704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="463" mass="50007" checksum="ED41B880F2270459" modified="2006-07-11" version="1">MGNEWLFLGLAILLVFANGFFVATEFAIVKIRATRLQALVDEGAPGAPTAMKMVEKLDAYLSATQFGITLASLGLGWLGEPAFARLLEPVLVQLVPEGAATTLAHSAAVVIGFSIITFLHIVLGELAPKSLAIQRPEDTTLAVALPMRVFYVLFYPAIVLLNGLAAWVLRVFGLQSVGEAHEAHSEDELLVILHSSAQAGAITTARAELLERALEMAQKTARQVMVPRNQVKFLDVEEPLEKCIADARAAGHTWLPVCRGNLDEVEGVVNAKDLFFLLSRGELRSLAQVQRPVLFIPEGATLEQLLAEFRRRRRQTALVVDEHGGTSGLVTIADVVAEVVGDVAELGRRMDEVRALPGGRFELPGTAQLDDLEERLDVNFDLDEDEEGEVTTIAGYLMTRLGRVPVKGDTLRLDMWRIVVDAVEGPRVVRVTVEPQARTASARTVSDGSAGAGEPPSGASNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D333</accession>
    <name>Q1D333_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoR1</name>
        <name evidence="6" type="ORF">MXAN_4778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554765.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D333">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4778"/>
    <dbReference type="EnsemblBacteria" id="ABF92948">
        <property type="protein sequence ID" value="ABF92948"/>
        <property type="gene ID" value="MXAN_4778"/>
    </dbReference>
    <dbReference type="GeneID" id="41362077"/>
    <dbReference type="KEGG" id="mxa:MXAN_4778"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_7"/>
    <dbReference type="OMA" id="GWGGQAW"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="109"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="230"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="454" mass="48537" checksum="C63A1A90AC7063CD" modified="2006-07-11" version="1">MPLRATLLPLLLPAVVVATLVALLDGPKEVFAAALVALAGSLMSLGVSRGTMQRQLDLLARHTRERAEGGASTAAPGVPERLDEVAGLEGAIDSLHAQLSARNAALTQEARTLTAVLDGMTEGVWVTDAEGTVVRHNDALRPLLASTNSPLTGQRPLALIRNEALHDAVMRACRESASSHLELTLDGHFPRTLSIRVTPLAKDLPGSAAVFHDVTELRRLEKVRKDFVANVSHELRTPITAIRGYAETLQGGALNDPVMAPKMVEIIHRQSERLSELVEDLLELSRLESREVSLKLARVTLADAAARAADTVRPKAGGKGQVVSLHVPQDLLAVGDPRAVEQVLLNLLDNAVKYTPAGGRVDVYGEYEQGRCVVRVKDTGVGIEAKHQSRIFERFYRVDKGRSRDMGGTGLGLAIVKHLLQAMDGEVKVESEPNGGSTFTIFLPLAASSSAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B4</accession>
    <name>Q1D3B4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">tgt</name>
        <name evidence="7" type="ORF">MXAN_4693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4693"/>
    <dbReference type="EnsemblBacteria" id="ABF88712">
        <property type="protein sequence ID" value="ABF88712"/>
        <property type="gene ID" value="MXAN_4693"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4693"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_7"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="6">
        <location>
            <begin position="15"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="247"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="378" mass="42154" checksum="F4B69E80E535E399" modified="2006-07-11" version="1">MVRFELLHEDTSGTKARRGRLHTPHGPVETPIFMPVGTVGSVKGVGPDDLLTLDAQIILGNTYHLMLRPGEALVGEMGGLHRFVSWNRPMLTDSGGFQVFSLSEKRKITEEGAAFQSHLDGSRHFLTPERSIDIQETLGADVIMAFDECPPSTENRAYLEASLARTTRWLHRCVKAWSRERSSLFGIVQGGLHEDLRKRHAEEVCAVDLPGYALGGYSVGEAPEAMHDGVAYSAPLLPRDKPRYLMGVGTPVDLVTCVEHGVDMFDCVLPTRCARNGLLFTSEGKVVIRNAAYARDNRPVDPACSCYTCRNFSRAYLRHLFAAQELLAMRLNTIHNLHYFLGLMAEVRRAVAEDRFATFAREFRARAKAQEAERTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B8</accession>
    <name>Q1D3B8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90071">
        <property type="protein sequence ID" value="ABF90071"/>
        <property type="gene ID" value="MXAN_4689"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4689"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098624_0_0_7"/>
    <dbReference type="OMA" id="VEFNRGA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188320" evidence="1">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="21391" checksum="03D30E384B28B40E" modified="2006-07-11" version="1">MRSSMHPRGTRAATLALAFATLGTAGSAAAQERRDGKRGDLNVFLRGGVGDYTGGLGDLTSTGPAWGVTLNIQPTTFLGFEVGYEGSRNGLTDSRLLEQPSLVRQGGSALVKVSPPFLTTVRPFVGAGLGVSHMNVRGPVEDLYQSDTMPEVPLAAGVEFNRGALTAGIRTTYRVLLSEGWADRAVEDTHGGLLDASLTLGARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3F5</accession>
    <name>Q1D3F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Flp pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554644.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D3F5"/>
    <dbReference type="STRING" id="246197.MXAN_4652"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88090">
        <property type="protein sequence ID" value="ABF88090"/>
        <property type="gene ID" value="MXAN_4652"/>
    </dbReference>
    <dbReference type="GeneID" id="41361952"/>
    <dbReference type="KEGG" id="mxa:MXAN_4652"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057068_3_1_7"/>
    <dbReference type="OMA" id="FFAKQWM"/>
    <dbReference type="OrthoDB" id="2060643at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29461" checksum="8640A1ED47A90AF8" modified="2006-07-11" version="1">MLKGKTPLVVALVLGLLAGVIAYSAIKKKEADVRRGWNLVPVVVAAQDVPEGTVITFEMISQRSVPEQFVTSSVVRPDSASYIVNQKVLVALQAGDPLLWSQFETTKAAERLSSKVQKKARALTIEAKHTTSVGGWIRPNDHVDVIGTFRDPQTDENVAVTLLQNVIVVATGKITGTTNVNLIPENQREYNNISLMVLPEEAEILVLAVELGQLTLSLRNEDDVDLIEERGRATISTLLSGERTRVLEQKRREIIQIIKGGAERAAGAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3F7</accession>
    <name>Q1D3F7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion system protein F domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554642.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4650"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85939">
        <property type="protein sequence ID" value="ABF85939"/>
        <property type="gene ID" value="MXAN_4650"/>
    </dbReference>
    <dbReference type="GeneID" id="41361950"/>
    <dbReference type="KEGG" id="mxa:MXAN_4650"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056917_4_0_7"/>
    <dbReference type="OMA" id="ITLRQMD"/>
    <dbReference type="OrthoDB" id="1559784at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="156"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF85939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="32688" checksum="6430EE04CFA5B1AA" modified="2006-07-11" version="1">MDDVLTPILIGSSALLFAGAVGFLGLGLYQTMLERFLSEVRDESTGGMKGFGSVAIRRLGAMNRRFMWPGYEAKARRNLIKAGEPQAYKPEDIMALQEVSAVVGLIMGLILLNGFGVSLVWAPLFLLFGMYYPLMWLNDQVKKRHLLISRALPYSLDLLTLSVEAGLDFTAALAKVVEKGKPGPLREELQLVLKQLKMGKTREEGLKSMIVRVDLPPLTTFVTALIQADKMGTSLGKVLRIQSTQMRIDRTQRAEKLAGEAPVKMLFPLIACIFPTVFMVLFGPIVFQFMFGNVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T4</accession>
    <name>Q1D3T4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554516.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4521"/>
    <dbReference type="EnsemblBacteria" id="ABF86036">
        <property type="protein sequence ID" value="ABF86036"/>
        <property type="gene ID" value="MXAN_4521"/>
    </dbReference>
    <dbReference type="GeneID" id="41361824"/>
    <dbReference type="KEGG" id="mxa:MXAN_4521"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959178_0_0_7"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="32970" checksum="3AC586BECB842EDB" modified="2006-07-11" version="1">MYLPQRDTASYRQFYYFLMAEVSKHSQRVYEHLKKTSFLENTIVVLTSDHGEMLGAHGGMMQKWYNAYQETLHVPCVISNPRLFPEPRKTEVVTSHVDLVPTLLGLAGIDADAARRELARDHSEAQLLVGRDLSGLVLGRESERHEPIYFMTDDNVESGLQMTNNLTGQAFAGVIQPKHIETVVTRLPELTGDTPWKYSCYSDNPRFFVGAAGNTDEVATARFIPREYECYDLTEDPLETRNRCSAVAAQPLSQDIRDALDKVLKEQWEKKRLLPQNLNRNAPTKGPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T6</accession>
    <name>Q1D3T6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4519"/>
    <dbReference type="EnsemblBacteria" id="ABF85867">
        <property type="protein sequence ID" value="ABF85867"/>
        <property type="gene ID" value="MXAN_4519"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4519"/>
    <dbReference type="HOGENOM" id="CLU_3120175_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="50" mass="5727" checksum="767F7BC55CF83CFE" modified="2006-07-11" version="1">MDARLIQQAIAHHGWLSPHWRVRTPEDSVTPAVSSTPFYTPEDRARALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3V5</accession>
    <name>Q1D3V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4499"/>
    <dbReference type="EnsemblBacteria" id="ABF89858">
        <property type="protein sequence ID" value="ABF89858"/>
        <property type="gene ID" value="MXAN_4499"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4499"/>
    <dbReference type="HOGENOM" id="CLU_2991976_0_0_7"/>
    <dbReference type="OMA" id="MSIVFDE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="57" mass="5999" checksum="210DA11C804C976A" modified="2006-07-11" version="1">MSIVFDEVQGSVVSGSTPDASQRPAAEPALTPPPVDPTSIARAIRLITQRKARLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3X9</accession>
    <name>Q1D3X9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase, DEAD/DEAH box family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554471.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4475"/>
    <dbReference type="EnsemblBacteria" id="ABF88218">
        <property type="protein sequence ID" value="ABF88218"/>
        <property type="gene ID" value="MXAN_4475"/>
    </dbReference>
    <dbReference type="GeneID" id="41361785"/>
    <dbReference type="KEGG" id="mxa:MXAN_4475"/>
    <dbReference type="eggNOG" id="COG1204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003747_0_0_7"/>
    <dbReference type="OMA" id="YEVQIQR"/>
    <dbReference type="OrthoDB" id="448903at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="283"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="580"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132750" checksum="B29C71403AC9461D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D401</accession>
    <name>ENO_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">MXAN_4451</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554450.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D401"/>
    <dbReference type="SMR" id="Q1D401"/>
    <dbReference type="STRING" id="246197.MXAN_4451"/>
    <dbReference type="EnsemblBacteria" id="ABF90869">
        <property type="protein sequence ID" value="ABF90869"/>
        <property type="gene ID" value="MXAN_4451"/>
    </dbReference>
    <dbReference type="GeneID" id="41361763"/>
    <dbReference type="KEGG" id="mxa:MXAN_4451"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_7"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000267061" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="432" mass="46144" checksum="25B1B5092CA3CE69" modified="2006-07-11" version="1">MTEISQILAREVLDSRGNPTVEAEVQLAGGARGRAAVPSGASTGEHEAIELRDGDKHRYLGKGVQKAVKNVVDVLAPALVGMDAADQFAVDQRMLELDGTATKGKLGANAILAVSMAAARAAADAHGLPLYRYVGGVQARTLPVPLMNILNGGAHADTRVDVQEFMVVPAGASSFAEGLRWGAEVFHALKKILKGRKLATGVGDEGGYAPDLPANEEALKLIMEAIDQAGFKAGEQLFLALDVAASEFFDKGSKKYKLKGEGKEYDSTGLLEYYRGLSERYPIISIEDGMAEDDWEGWKKLTDALGSRMQLVGDDLFVTNVERLGRGIETGTANSILVKVNQIGTLTETFDAVRMAHRAGYTSVMSHRSGETEDTTIADLAVALDCGQIKTGSASRSDRVAKYNQLLRIEGELGAAARYAGKSVFRALNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F2</accession>
    <name>Q1D4F2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554299.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4296"/>
    <dbReference type="EnsemblBacteria" id="ABF90173">
        <property type="protein sequence ID" value="ABF90173"/>
        <property type="gene ID" value="MXAN_4296"/>
    </dbReference>
    <dbReference type="GeneID" id="41361607"/>
    <dbReference type="KEGG" id="mxa:MXAN_4296"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_13_7"/>
    <dbReference type="OMA" id="WELTYGE"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1435" mass="158442" checksum="E4A39E7FDF077D2C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4I6</accession>
    <name>Q1D4I6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4262</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554265.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4262"/>
    <dbReference type="EnsemblBacteria" id="ABF89018">
        <property type="protein sequence ID" value="ABF89018"/>
        <property type="gene ID" value="MXAN_4262"/>
    </dbReference>
    <dbReference type="GeneID" id="41361577"/>
    <dbReference type="KEGG" id="mxa:MXAN_4262"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391157_0_0_7"/>
    <dbReference type="OMA" id="MVAHVVR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="480"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="702" mass="76411" checksum="6C0574769F9A8A91" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S6</accession>
    <name>Q1D4S6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_4172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554175.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4172"/>
    <dbReference type="EnsemblBacteria" id="ABF90023">
        <property type="protein sequence ID" value="ABF90023"/>
        <property type="gene ID" value="MXAN_4172"/>
    </dbReference>
    <dbReference type="GeneID" id="41361490"/>
    <dbReference type="KEGG" id="mxa:MXAN_4172"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_7"/>
    <dbReference type="OMA" id="ATVITMM"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="316"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="44297" checksum="270DE00844ADC975" modified="2006-07-11" version="1">MRAFLDNLRLALGTFLGNPLRSLLTLLGIVIGVATVITMMGLIEGLRVKVNNDLGRMGAHTFQVTKWPAGGFGRINWAKFAKRKDFEMPDSRAIEESCPSVGTVVPTDDEGGQKLATASSETRPSVRVFGTPANYPLVSGVSVQAGRYFNEVEALDGRYVALLGTDVSDALFPGMNPVGHEVRIKGRPFRVIGLLQKRGSMLGMFSLDNQVMIPLSVFHQLYGKKRSLDISVQAKSPELFSKAQDEVASLMRRRRDVPANMPNDFELHTNESVTASFNQLSQVITIAGVGVCLLSLVVGGIGILNIMLVSVMERTREIGVRKALGARKRRILGQFATEAVLLSLMGGALGLGLGFGLVFLGNWMMGFPMQVPPWAVGLALFMSCGVGLLFGIYPAARAAKLDPVEAMRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4T3</accession>
    <name>Q1D4T3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_4165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D4T3">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4165"/>
    <dbReference type="EnsemblBacteria" id="ABF89770">
        <property type="protein sequence ID" value="ABF89770"/>
        <property type="gene ID" value="MXAN_4165"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4165"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_19_7"/>
    <dbReference type="OMA" id="RWNDVYL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="249"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="311"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="56462" checksum="2CFAA6475F58D946" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A1</accession>
    <name>Q1D5A1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3992"/>
    <dbReference type="EnsemblBacteria" id="ABF91637">
        <property type="protein sequence ID" value="ABF91637"/>
        <property type="gene ID" value="MXAN_3992"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3992"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643771_0_0_7"/>
    <dbReference type="OMA" id="QKTDILF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="46733" checksum="9016835AC034929E" modified="2006-07-11" version="1">MIAPLASDAAPRRGAQLFERPPMKLRPFAHLLLLPSLLWTSCRSPVDEPGSNLPGKCESESPVIAPQKTDILFVIDNSGSMEEEQNAIATELPAFLEALKEGSGVSQDFRVGVITTSVYRLAMFQGQTTLREYAKESGRLQRVPDAAGNPTDERFIDGTDPYVLEKFRRLVIQGTDGSGQETPFEAVRLAVTEPLVSTPGAENGNAGFLRDGARLLVAVVTDEEDCSTIQRPPPVWVSDDTSIDNCSEQSHLLTPVEEYFATFQQLRDSTGASRQVLWATIGPVALSDKRAELIRDATPDGVFVRNVDCPTSYGPGHRQRAMAEAFDQGLDNLDSICRDNYRDTLLRIAELATVAQSIEVVNLPDPRLVQVELTRANDEVERCSVAAGDLRYEASTEAYPARLFFQSSCLRRADDKKVEVKVLCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P6</accession>
    <name>Q1D6P6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553513.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3482"/>
    <dbReference type="EnsemblBacteria" id="ABF88879">
        <property type="protein sequence ID" value="ABF88879"/>
        <property type="gene ID" value="MXAN_3482"/>
    </dbReference>
    <dbReference type="GeneID" id="41360829"/>
    <dbReference type="KEGG" id="mxa:MXAN_3482"/>
    <dbReference type="HOGENOM" id="CLU_729226_0_0_7"/>
    <dbReference type="OMA" id="VRRFRDY"/>
    <dbReference type="OrthoDB" id="1248845at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188438" evidence="1">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="41508" checksum="E170E0838DBBBFBD" modified="2006-07-11" version="1">MRMTVTCGALLSLAARLALAQPAPPPAGELTSPSREDRAAGYCDFVRGVGSAEAALELAPELFGAFGVVNAGEASSGAGTTPLGEPTPRVTAGLMYDLVGIYRGRAIHKRAEADCRRQRAMVVLESAIRQGSGLGEQAALEARARVLEEALPHAEALLTSLRNDMKQGLVTLEELNAVQVRLDGLRQLSSNTQIARERLAARPRVQEGQRLESVLNELRAADDQLEAYHGALRSSRAWRVSVRGGYDKLIDVDQDLPLFGQLTLSYNLGHLWLGSANARAREGRRRATLDDVSGVPQRVNELVAELRTVHRTEEGRLREVSTLVSDLEAQLQSMDALQTREIRRFRGYLMMELTRLRAEQAYLRAHVESLQSFLGARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7B8</accession>
    <name>Q1D7B8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ccmC</name>
        <name evidence="10" type="ORF">MXAN_3256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553301.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3256"/>
    <dbReference type="EnsemblBacteria" id="ABF86608">
        <property type="protein sequence ID" value="ABF86608"/>
        <property type="gene ID" value="MXAN_3256"/>
    </dbReference>
    <dbReference type="GeneID" id="41360608"/>
    <dbReference type="KEGG" id="mxa:MXAN_3256"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066538_1_0_7"/>
    <dbReference type="OMA" id="FHVPMWF"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="9">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="26360" checksum="0D8998D294844903" modified="2006-07-11" version="1">MGKFIKWGLPALALVVLAAGWWLGLEWAPPDREMGDVQRIMYVHVPLQWVAMVAMAINFVVAISYLMKASWKLDAAAEASAEIGLVLGTAGMITGAIWGRPTWGVYWSWDPRLTSQAIMLVTYTGYLVLRRFVEDPEKRATWSSVVAIIGAINLPIVWFSVRWWRSLHQVQSTPKTVDPEMTLALRVSAFGMLFLTLWFLVLRYRQALAEREAEVALPDALPSDLAAAGGANSTRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D1</accession>
    <name>Q1D7D1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553288.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3243"/>
    <dbReference type="EnsemblBacteria" id="ABF86467">
        <property type="protein sequence ID" value="ABF86467"/>
        <property type="gene ID" value="MXAN_3243"/>
    </dbReference>
    <dbReference type="GeneID" id="41360596"/>
    <dbReference type="KEGG" id="mxa:MXAN_3243"/>
    <dbReference type="eggNOG" id="ENOG5033M8B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007709_0_0_7"/>
    <dbReference type="OMA" id="QWHENEQ"/>
    <dbReference type="OrthoDB" id="946623at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="30325" checksum="4E14A5D3161CBA00" modified="2006-07-11" version="1">MTMEPMRRIRTSTLTTDDNGRLSYEGAGFSGLAYRVEDDGVVRELLAVSEGSVSGTSDDWLPQLEGARLDRACLELADAYGPLLWRGAPVDGIVYTFNRQGLCLVEEAYASGQPADTARREWYPSGAPKADMRNGDGWAWFEDGRVRARATPEQTLLNLPVRDDGSLSGIVLHDPSLLDVTSVKPMAFSNEFLLTGRGVDDRLLQTLRDETGLGTVLRLHLIDTAVTPASVEVLASLKSLNELWLRRNRALGPGQVEALRARRPDGVVHYEEDPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L0</accession>
    <name>Q1D7L0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase, M13 (Neprilysin) family</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553209.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3160"/>
    <dbReference type="EnsemblBacteria" id="ABF87582">
        <property type="protein sequence ID" value="ABF87582"/>
        <property type="gene ID" value="MXAN_3160"/>
    </dbReference>
    <dbReference type="GeneID" id="41360519"/>
    <dbReference type="KEGG" id="mxa:MXAN_3160"/>
    <dbReference type="eggNOG" id="COG3590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_7_2_7"/>
    <dbReference type="OMA" id="FGWAQVW"/>
    <dbReference type="OrthoDB" id="305005at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="9">
        <location>
            <begin position="69"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M13" evidence="8">
        <location>
            <begin position="499"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="703" mass="78409" checksum="6B0296E4F61FB436" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7N7</accession>
    <name>Q1D7N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553183.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3133"/>
    <dbReference type="EnsemblBacteria" id="ABF89552">
        <property type="protein sequence ID" value="ABF89552"/>
        <property type="gene ID" value="MXAN_3133"/>
    </dbReference>
    <dbReference type="GeneID" id="41360494"/>
    <dbReference type="KEGG" id="mxa:MXAN_3133"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081828_0_0_7"/>
    <dbReference type="OMA" id="FAGTSRM"/>
    <dbReference type="OrthoDB" id="1783234at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="24125" checksum="676792CEE8209DD5" modified="2006-07-11" version="1">MAEPTPGLTAAGEGRLSGRAIMGWAAFSGLLLASILVPFAWFGDSLEAASGHFLATQPPSWQVALLLGGLLAGDAVLPVPSSLVGTAAGGLLGFWGGAATSWLGMMAGCVVGYCLGARAGTAALRRMAGDAELGRLTRAAERMGPWFLLAFRAVPVLAETSVLFAGTSRMRPRTFLTVSALANLGVSVTYAALGASAARMESFLLLFAGMVLLPGLALAWMRRRTPPHPDPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Z6</accession>
    <name>Q1D7Z6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC_dehydrat_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553074.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3018"/>
    <dbReference type="EnsemblBacteria" id="ABF92766">
        <property type="protein sequence ID" value="ABF92766"/>
        <property type="gene ID" value="MXAN_3018"/>
    </dbReference>
    <dbReference type="GeneID" id="41360379"/>
    <dbReference type="KEGG" id="mxa:MXAN_3018"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116276_0_0_7"/>
    <dbReference type="OMA" id="WTAIIRN"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="17158" checksum="A04F6F038EA49CDD" modified="2006-07-11" version="1">MALDKQFIGREYGPYHYTLGEEKMREFTLAVGGAKPGAGTPGEPPAHVSPLLYDAQAAKAGPHGGLIAFPSFAVVFAIRPFSAAIADPALNINMQMLVHGEQDLEFLDVMRPGDVMTTTGRIADLYERARMGFVIVTSESRNQHGTLVVKGTWTAIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8E3</accession>
    <name>Q1D8E3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552930.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2869"/>
    <dbReference type="EnsemblBacteria" id="ABF88008">
        <property type="protein sequence ID" value="ABF88008"/>
        <property type="gene ID" value="MXAN_2869"/>
    </dbReference>
    <dbReference type="GeneID" id="41360238"/>
    <dbReference type="KEGG" id="mxa:MXAN_2869"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110628_0_0_7"/>
    <dbReference type="OMA" id="RATIVCI"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22621" checksum="97EB4DC148609D9D" modified="2006-07-11" version="1">MGTKEQEARERILRATIVCIGRDGLDATGIREIAREAQVNSAAISYYFRSKEKLVALALEQTLDQAFGNVLEDFDRLRLEGLGIREAFETLLEDLMSNSLRYPYIAHAHFHDALAHQRYDSSAIQRFNAFLAELAGRLAPGAPHLPENRLRMALTQVWASLSLLSMMPRLFDQFILLDFGTLDTRRAWVQQASRLLFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I7</accession>
    <name>Q1D8I7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase, IS3 family, internal deletion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2821"/>
    <dbReference type="EnsemblBacteria" id="ABF87677">
        <property type="protein sequence ID" value="ABF87677"/>
        <property type="gene ID" value="MXAN_2821"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2821"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184025_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="24736" checksum="B2D5F22791275206" modified="2006-07-11" version="1">MQRQAVGAGAHDGHLARAPCHDVPAPCPPTHRGHACSSARPQDGADGRGTAGGHPRRAGGGALPGRGAPQGVGSAACPGRAHLEGARPAAHARSGAAGTRPHPPAAGAAQPRRLDYHRQARCHVGADATCTVTTLEGQATVFIAVNHGTAECVGIHAAKVGSRFEALEPIRQGIKARFGRKEQLPWAHAFATVEELRLALLEWAYQYNEHWLLERHDFLSPSQARRELRLKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P5</accession>
    <name>Q1D8P5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552828.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2761"/>
    <dbReference type="EnsemblBacteria" id="ABF90464">
        <property type="protein sequence ID" value="ABF90464"/>
        <property type="gene ID" value="MXAN_2761"/>
    </dbReference>
    <dbReference type="GeneID" id="41360138"/>
    <dbReference type="KEGG" id="mxa:MXAN_2761"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134465_0_0_7"/>
    <dbReference type="OMA" id="MRARDKA"/>
    <dbReference type="OrthoDB" id="1981315at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="118" mass="12572" checksum="0848F2D9375106E6" modified="2006-07-11" version="1">MRTVDEWKAALRAALKEAMRTRSPQASAVLRELLAAIDNAEAPDMRVAPTAVGDVFAGSAGGLGHGEVPRLALTPEAVQAVIDRELQERRDAVALYEKLGKQDEASAVKAQLDVLLAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D921</accession>
    <name>UVRC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">MXAN_2633</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552703.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D921"/>
    <dbReference type="SMR" id="Q1D921"/>
    <dbReference type="STRING" id="246197.MXAN_2633"/>
    <dbReference type="EnsemblBacteria" id="ABF90670">
        <property type="protein sequence ID" value="ABF90670"/>
        <property type="gene ID" value="MXAN_2633"/>
    </dbReference>
    <dbReference type="GeneID" id="41360009"/>
    <dbReference type="KEGG" id="mxa:MXAN_2633"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_7"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000264916" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="646" mass="73432" checksum="7DA98D15EBA3C7B1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D994</accession>
    <name>Q1D994_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Semialdehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552630.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2560"/>
    <dbReference type="EnsemblBacteria" id="ABF90333">
        <property type="protein sequence ID" value="ABF90333"/>
        <property type="gene ID" value="MXAN_2560"/>
    </dbReference>
    <dbReference type="GeneID" id="41359938"/>
    <dbReference type="KEGG" id="mxa:MXAN_2560"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_7"/>
    <dbReference type="OMA" id="YPMPMLV"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="36024" checksum="650447C72A40B3C4" modified="2006-07-11" version="1">MRDDLTIGVVGATGVVGREVLAALYAQDVPAEQVRVFGSERSKGMEVEYGEDSLEVEQATPDAFRGVKLVLLATPAEASRTLAPAAQAAGAWVVDASSAFRGDGNVPMVLPGFNTDVLGAGFTFKGRIVCLPGAVTTAAVHVVEPLRKAFGVARAQVTALMAASSAGVRGVAELEKQTADLLSGREPEPHAFPHRVGFNLVPQVGGFMVNSPWTEEEGGWTLEAARLFSSKGDVPVIAGTAVQVPTFYGHGLTLNVQLKKAGPVEQVRAALKTSGALKVLDVPGERVYPMPMLVTSDPAVHVGRVRAFPQAPEWVTLFASVDNASRGAALNLVEAGLRLAERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D997</accession>
    <name>Q1D997_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase, M50A (S2P protease) subfamily</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_2557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2557"/>
    <dbReference type="EnsemblBacteria" id="ABF85942">
        <property type="protein sequence ID" value="ABF85942"/>
        <property type="gene ID" value="MXAN_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2557"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_0_0_7"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="299"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF85942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="555" mass="59247" checksum="F714059A8BBAEDB0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B3</accession>
    <name>Q1D9B3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D9B3"/>
    <dbReference type="STRING" id="246197.MXAN_2541"/>
    <dbReference type="EnsemblBacteria" id="ABF87056">
        <property type="protein sequence ID" value="ABF87056"/>
        <property type="gene ID" value="MXAN_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2541"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_469820_0_0_7"/>
    <dbReference type="OMA" id="YYENCRY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188384" evidence="2">
        <location>
            <begin position="25"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="673" mass="75995" checksum="02C63C2FDD4DD387" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9C1</accession>
    <name>Q1D9C1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552603.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2533"/>
    <dbReference type="EnsemblBacteria" id="ABF86817">
        <property type="protein sequence ID" value="ABF86817"/>
        <property type="gene ID" value="MXAN_2533"/>
    </dbReference>
    <dbReference type="GeneID" id="41359911"/>
    <dbReference type="KEGG" id="mxa:MXAN_2533"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_3_0_7"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="16869" checksum="C8DA190E989E1A50" modified="2006-07-11" version="1">MKTNSARLLDSLGVKYALRDYDVDLEDLSAESVAAKVGMPAEQVFKTLVARGDRTGVLMAVVPGNAELDLKALARLSGDRKVDTVPLKELQPLTGFIRGGCTAIGGKKDYPVYVDETMELFDAIAVSAGVRGTQLVLAPADYLRVTKAKTGPISRDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D0</accession>
    <name>Q1D9D0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine kinase</fullName>
            <shortName evidence="3">HK</shortName>
            <shortName evidence="3">HSK</shortName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thrB</name>
        <name evidence="5" type="ORF">MXAN_2524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudomonas-type ThrB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552595.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2524"/>
    <dbReference type="EnsemblBacteria" id="ABF92040">
        <property type="protein sequence ID" value="ABF92040"/>
        <property type="gene ID" value="MXAN_2524"/>
    </dbReference>
    <dbReference type="GeneID" id="41359901"/>
    <dbReference type="KEGG" id="mxa:MXAN_2524"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053300_0_0_7"/>
    <dbReference type="OMA" id="FDFEMAC"/>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05153">
        <property type="entry name" value="HomoserineK_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00301">
        <property type="entry name" value="Homoser_kinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005280">
        <property type="entry name" value="Homoserine_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="4">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="36018" checksum="22B614F59DF6D053" modified="2006-07-11" version="1">MAVHTALPREAFERVAEAFGLGAVREVTPIPQGSINTNHRVETQSGRYFVRHTTVRSADDLRFESALLAHLAAYHFPGPVQVTTRDGATFLELEGGRVSVFRWLPGEELRHPALTADHLERLGAELGKLHRDTQSFSGSRENPYGPETVSGWLEALVAHPDAELAAVARELQRDMETSRAARQGLEPRGVIHADLFMDNVKWLGDRVGAFFDFEMACREDYGLDVAITLNAWCFDGGQYLPELCRAFIRGYVDVRPLSAVERTNLFGHALYGAVRFTASRIRDYHLSPLPADKLVRKDYRTYLNRARALNAMGPEGFAALLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Q5</accession>
    <name>Q1D9Q5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552473.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2398"/>
    <dbReference type="EnsemblBacteria" id="ABF88813">
        <property type="protein sequence ID" value="ABF88813"/>
        <property type="gene ID" value="MXAN_2398"/>
    </dbReference>
    <dbReference type="GeneID" id="41359782"/>
    <dbReference type="KEGG" id="mxa:MXAN_2398"/>
    <dbReference type="eggNOG" id="COG3482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045640_0_0_7"/>
    <dbReference type="OMA" id="SVWHHEL"/>
    <dbReference type="OrthoDB" id="1249101at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="41497" checksum="450D0FA8C651389E" modified="2006-07-11" version="1">MKRRADKLVVFLGPSLPEAEAKRLAPCTVLPPARQGDVWRAQRLRPRAIALVDGVFEAQPSVWHHELLAALEAGVAVFGGGSMGALRAAELAPHGVVGVGRIFEWYRDGDVVDDSEVALLHADGEHGWRPLTVPLVNVRHAAACAAQARVLTRDAARALVDAGQSVFYQERTWARVLEAVAPRWSASTRAAWDAWFPHGAEDLKRQDALACLRTAAEWVASGAPAPHGAPREPSSLVRRRRLVDDVTATQAGAVSSGQVLDVLRASPNAPALAEAGLRRALLAGWARTLGLGVSDAEVAEEEARWWQAQRVPVSRREAHLARLGLDAVGLRRLCGELALERLVLAHSARLLPDGPSWDEALAAEARLSGAWADAAEAVDPTERVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W2</accession>
    <name>Q1D9W2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89669">
        <property type="protein sequence ID" value="ABF89669"/>
        <property type="gene ID" value="MXAN_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2341"/>
    <dbReference type="HOGENOM" id="CLU_1218696_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="24410" checksum="6E956F463A1BF131" modified="2006-07-11" version="1">MHPRGTRSVKGALQTTEPLMRPLLRGNQLHPHEASILAMHLVRVALVVGKAMVLALLQRLDGGLLAQDVRTALDQLGEGAPHARALHGLTTHLQDALANLLDPVLVVVLAILQRVTGQSVRDVPDRLAIGLHGGDFAAQERVERLDVLVGARHRWPPWVTGESGLPQKVMPAAAWATRARLPAPFQGLRGRSSDGAVSRPPDGRASGRPPGWPSTAYRIKEDGLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y5</accession>
    <name>Q1D9Y5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glutathione reductase</fullName>
            <shortName evidence="11">GRase</shortName>
            <ecNumber evidence="11">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">gor</name>
        <name evidence="15" type="ORF">MXAN_2318</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Maintains high levels of reduced glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552393.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2318"/>
    <dbReference type="EnsemblBacteria" id="ABF89146">
        <property type="protein sequence ID" value="ABF89146"/>
        <property type="gene ID" value="MXAN_2318"/>
    </dbReference>
    <dbReference type="GeneID" id="41359705"/>
    <dbReference type="KEGG" id="mxa:MXAN_2318"/>
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    <sequence length="472" mass="50765" checksum="5E87797F9EBE5DF4" modified="2006-07-11" version="1">MARYDFDLFTIGGGSGGVAASRRAGAHGAGVALCEDRDVGGTCVHRGCVPKKLLVYGAHFREEFQDAEGYGWTVQEPLFTWSKLLAAKDKELDRLRGVYARLLRDSGVTLLEGRGRVVDPHTVEVAGKLYTAERILIATGSRPYLPPDITGIEHAITSDEALSFPELPRRLAVVGAGYIGVELAGVFHGLGSKVTMLIRGASVLGGFDDDVRSFLTDEMRKKGIELMTDTFIRDIEKRAEGGVSLLTGGGETVEADAVLFATGRVPNSGGLGLEEVGVTLDARGAVVVDAWSRTSVESIYAVGDITDRINLTPVAISEGRALAETLFNDNPTQMDHTNVPSAVFSQPPVASVGLTEQEARERHGKLDIYVTSFRPMKHTLSGRNERTMMKVVVERESNRVLGCHMVGTDAPEIIQGLAVAVKCGVTKKQLDATVGIHPTAAEEFVTLRDKRPDPDERLAAELGRDAAASTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAA1</accession>
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        <submittedName>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="288" mass="31615" checksum="200CADD469D426B1" modified="2006-07-11" version="1">MNPADAFDPLRPRLLRIAYRMLGIVAEAEDVVQEAYLRWHQTDRAAVRDAEAVLVRTVTRLCLDVLKSARVRREEYVGTWLPEPIVDAVEGDDLTLPLMMALERLSPLERAAFLLHDVFGMDFEEVAKAMGRAPAACRQLASRARAHVREARPRFPVSEAQGSELASAFYAASRSGDMGALQALLAQDVVVYSDGGGKVKAALNPIYGQEKTVRFFEGLLRITGVNASQLVHEGFIDGLPAFVTLEKDGTLQTTALDIEDGRVATIYVTRNPDKLQGIRGLVGDKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAW0</accession>
    <name>Q1DAW0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552068.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1978"/>
    <dbReference type="EnsemblBacteria" id="ABF87168">
        <property type="protein sequence ID" value="ABF87168"/>
        <property type="gene ID" value="MXAN_1978"/>
    </dbReference>
    <dbReference type="GeneID" id="41359389"/>
    <dbReference type="KEGG" id="mxa:MXAN_1978"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066805_0_0_7"/>
    <dbReference type="OMA" id="WSKSRHE"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="327" mass="37851" checksum="7CAB2A90FB8DC20F" modified="2006-07-11" version="1">MRAFMRRPPLSNDFSWSKSRHEKFSECLRAYYLYYYRSWGGWEASAPKDVRELYVLKKLGNRYTWAGSVVHESIKDVLLDWRAGREVDPAAVEARTRKLMQDDFRHSRSKNYWSQKYRKQFTGLVEHEYAEAVPDEAWKQNWETVRSALSWFFSSRWKDLAHSLKPEQWLEVDAGFDFAHFTLDGLKVFAIPDFAFVDADGTPVVVDWKTGKSRDGYDEQVLGYALYVAQRYRFPVEKVRASLVYLNEGKEQDVAVDPEAMASFHRHFEQSVAKMRSLLKDAATNTPLDASAFPPTESLTSCARCVFRRPCGREGAAPEAPQPQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB41</accession>
    <name>Q1DB41_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551988.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1886"/>
    <dbReference type="EnsemblBacteria" id="ABF89282">
        <property type="protein sequence ID" value="ABF89282"/>
        <property type="gene ID" value="MXAN_1886"/>
    </dbReference>
    <dbReference type="GeneID" id="41359302"/>
    <dbReference type="KEGG" id="mxa:MXAN_1886"/>
    <dbReference type="HOGENOM" id="CLU_2863098_0_0_7"/>
    <dbReference type="OMA" id="MGQRFYE"/>
    <dbReference type="OrthoDB" id="2051468at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="67" mass="7375" checksum="80067A20A2EBD830" modified="2006-07-11" version="1">MSGPAFFQTYMGQRFYETTMPQLVRQLGRLNDNVERLVAVAEQLAGQKEASSAEPARPTTTAGTEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBC1</accession>
    <name>Q1DBC1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1806"/>
    <dbReference type="EnsemblBacteria" id="ABF88602">
        <property type="protein sequence ID" value="ABF88602"/>
        <property type="gene ID" value="MXAN_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1806"/>
    <dbReference type="eggNOG" id="COG5483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962065_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="33627" checksum="61E75CB27887E09A" modified="2006-07-11" version="1">MLFSRQRQLLQLLDALGGTAGKLDFQKLLFLYCQEQPTNAPYDFVPYKFGAFSFTSYADCRKLVAHGLIEDDDGWRLTDAGRKVIGRTPDLQLSAFARSHRLRGDELVVDTYRRYPFFATRSEIAERVLKGDEAALARIEVVRAARSNSALHTIGYEGHSVESYLNELLQNGITILCDVRRNPISRKYGFSKNTLARICENVGIRYEHLPELGIASEQRQGLDTQADYDALFDDYERTWLPKQGTVLEKIRTWVGEKERVALTCYEHAPNQCHRHCVAEALEDKFGKDYNAKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR2</accession>
    <name>Q1DBR2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551770.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1659"/>
    <dbReference type="EnsemblBacteria" id="ABF87495">
        <property type="protein sequence ID" value="ABF87495"/>
        <property type="gene ID" value="MXAN_1659"/>
    </dbReference>
    <dbReference type="GeneID" id="41359100"/>
    <dbReference type="KEGG" id="mxa:MXAN_1659"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_7"/>
    <dbReference type="OMA" id="VFNHSRI"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13383" checksum="DE361C519A5FBAF3" modified="2006-07-11" version="1">MPPERINRGDVFWVEPDDSRGPVPSYSHPHVVVQDDVFNHSRITTVVVCALTSNLHRASEPGNVLLEVGEGNLPKQSVVVVSQVSSVDKARLGERIGALSDARVEQILAGLRFQQVSFFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBW2</accession>
    <name>Q1DBW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1609"/>
    <dbReference type="EnsemblBacteria" id="ABF89688">
        <property type="protein sequence ID" value="ABF89688"/>
        <property type="gene ID" value="MXAN_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1609"/>
    <dbReference type="HOGENOM" id="CLU_2936766_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="56" mass="5901" checksum="BC85E6DBF1DA81A9" modified="2006-07-11" version="1">MAPEETLSAAPAHSEPATSEAAHSEVSAAPEKLDEIEEIDFLLEEIESKIAPLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC72</accession>
    <name>Q1DC72_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551610.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1499"/>
    <dbReference type="EnsemblBacteria" id="ABF86005">
        <property type="protein sequence ID" value="ABF86005"/>
        <property type="gene ID" value="MXAN_1499"/>
    </dbReference>
    <dbReference type="GeneID" id="41358945"/>
    <dbReference type="KEGG" id="mxa:MXAN_1499"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302694_0_0_7"/>
    <dbReference type="OMA" id="QATCEGG"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="20361" checksum="E64FEFCE8CDDA457" modified="2006-07-11" version="1">MRILFCGVGAIGSTAAVLCRNLEASLVFVDFDRVESKNLLAQAYVKPSVGKNKAEALKLQLLNLHGVKAESHGVRLTRDNAEALCGGAGLLVDCMDNQHSRQVLIDYARRTGKPLVHGAVNADGTFGLVRWDERFTPDAEDAQGQATCEGGAHLPLLGLLSATLARAIQDFVKHGTRRDSLVNLSSVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCE3</accession>
    <name>Q1DCE3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551540.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1423"/>
    <dbReference type="EnsemblBacteria" id="ABF86086">
        <property type="protein sequence ID" value="ABF86086"/>
        <property type="gene ID" value="MXAN_1423"/>
    </dbReference>
    <dbReference type="GeneID" id="41358869"/>
    <dbReference type="KEGG" id="mxa:MXAN_1423"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000985_0_0_7"/>
    <dbReference type="OMA" id="ETRVISW"/>
    <dbReference type="OrthoDB" id="791691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1491" mass="157375" checksum="A884492E33A34708" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCH8</accession>
    <name>Q1DCH8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">recA</name>
        <name evidence="13" type="ORF">MXAN_1388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551505.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1388"/>
    <dbReference type="EnsemblBacteria" id="ABF88681">
        <property type="protein sequence ID" value="ABF88681"/>
        <property type="gene ID" value="MXAN_1388"/>
    </dbReference>
    <dbReference type="GeneID" id="41358835"/>
    <dbReference type="KEGG" id="mxa:MXAN_1388"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_7"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0000269"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="12">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="69"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="39007" checksum="3B7DE3B680D2F86F" modified="2006-07-11" version="1">MAVNQEKEKAIELAMSAVERQFGKGSIMRLGNDEPMMRDVQAIPTGSISLDIALGVGGVPKGRIIEIFGPESSGKTTLCLHIVAEAQKRGGICGYVDAEHALDVGYARKLGVRTDDLLLSQPDTGEQALEIAEMLVRSGAIDVLVVDSVAALVPKAELEGEMGDAHMGVQARLMSQALRKLTGTIAKSQTCVIFINQIRMKIGVMFGNPETTTGGNALKFYASQRLDIRRIGAIKNGDNVVGSRTRVKVVKNKVAPPFKEVEFDIMYGTGISREGDLIDLASNENIVEKSGSWFSFNGERIGQGRENVKEYLREHPEIAKDIEGRVLEKYGIGKSGAPVAAAPDESAPAEGGSEKRGRVKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD03</accession>
    <name>Q1DD03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551330.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1211"/>
    <dbReference type="EnsemblBacteria" id="ABF88715">
        <property type="protein sequence ID" value="ABF88715"/>
        <property type="gene ID" value="MXAN_1211"/>
    </dbReference>
    <dbReference type="GeneID" id="41358660"/>
    <dbReference type="KEGG" id="mxa:MXAN_1211"/>
    <dbReference type="eggNOG" id="ENOG5033BX1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118598_0_0_7"/>
    <dbReference type="OMA" id="RKHPERW"/>
    <dbReference type="OrthoDB" id="1736012at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17566" checksum="65E4CD15C151BAB5" modified="2006-07-11" version="1">MARPTKLTPELQQQICEHLRSGLFRRAAAGLVGVDEQTVSRWFHRGASEARGLYREFFVAVNRAEAEFMQGATETLQAAATTNPKHVQWLLSRRFPELYGRRDNVEAKSPEDQAADTAALRELLIDRLGKFLPDELPASVPAEAAPSEQFEDKGASDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDF6</accession>
    <name>ASTB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-succinylarginine dihydrolase</fullName>
            <ecNumber evidence="1">3.5.3.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">astB</name>
        <name type="ordered locus">MXAN_1056</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19533"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58241"/>
            <dbReference type="ChEBI" id="CHEBI:58514"/>
            <dbReference type="EC" id="3.5.3.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinylarginine dihydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551177.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDF6"/>
    <dbReference type="SMR" id="Q1DDF6"/>
    <dbReference type="STRING" id="246197.MXAN_1056"/>
    <dbReference type="EnsemblBacteria" id="ABF87851">
        <property type="protein sequence ID" value="ABF87851"/>
        <property type="gene ID" value="MXAN_1056"/>
    </dbReference>
    <dbReference type="GeneID" id="41358509"/>
    <dbReference type="KEGG" id="mxa:MXAN_1056"/>
    <dbReference type="eggNOG" id="COG3724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053835_0_0_7"/>
    <dbReference type="OMA" id="TLNDWVD"/>
    <dbReference type="OrthoDB" id="567590at2"/>
    <dbReference type="UniPathway" id="UPA00185">
        <property type="reaction ID" value="UER00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009015">
        <property type="term" value="F:N-succinylarginine dihydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:arginine catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019545">
        <property type="term" value="P:arginine catabolic process to succinate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01172">
        <property type="entry name" value="AstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037031">
        <property type="entry name" value="AstB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007079">
        <property type="entry name" value="SuccinylArg_d-Hdrlase_AstB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04996">
        <property type="entry name" value="AstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03241">
        <property type="entry name" value="arg_catab_astB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000262358" description="N-succinylarginine dihydrolase">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="440" mass="48058" checksum="F52B6766873B98DA" modified="2006-07-11" version="1">MREYNFDGLVGPTHNYGGLSPGNLASQSHVGEPSHPRDAALQGLEKMRFVSALGVGQAVLPPQPRPSLHALRALGFTGSDEEVITRAAREAEHLLRLTSSASSMWTANAATVAPSADTADGRVHLTPANLSQMYHRAIEAETTHSVLRAIFSNEKYFAVHAPLPGSGHFADEGAANHTRLATPGHAGVHLLAWGRSAWQDVQGPSRFPARQTLEASQALARLHQLDAKSVLFPQQHPEGIDAGAFHTDVLAVGNERFLMLHELAFVDHAGLLAVLREKLGQDFRAVVATKAELPAKDAVKAYPFNSQVLTLPDGTMAIVAPIESRETPAARQFLERVVAEDTPVKAVHYLDVRQSMNNGGGPACLRQRVWLTDEERGAIKADVFYTPALHDSLAGWVRRHYREVLRPKDLQDPQLARETMTALDELTRILNLGSVYDFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDI7</accession>
    <name>Q1DDI7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Capsular exopolysaccharide family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_1025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1025"/>
    <dbReference type="EnsemblBacteria" id="ABF90823">
        <property type="protein sequence ID" value="ABF90823"/>
        <property type="gene ID" value="MXAN_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1025"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_2_1_7"/>
    <dbReference type="OMA" id="VYGPKHP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wzz" evidence="9">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="10">
        <location>
            <begin position="366"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CbiA" evidence="8">
        <location>
            <begin position="512"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="710" mass="78360" checksum="D63F46ADF837EBFC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS8</accession>
    <name>Q1DDS8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551055.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0934"/>
    <dbReference type="MEROPS" id="S01.453"/>
    <dbReference type="EnsemblBacteria" id="ABF90756">
        <property type="protein sequence ID" value="ABF90756"/>
        <property type="gene ID" value="MXAN_0934"/>
    </dbReference>
    <dbReference type="GeneID" id="41358393"/>
    <dbReference type="KEGG" id="mxa:MXAN_0934"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_7"/>
    <dbReference type="OMA" id="HAGPYDD"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010603849" description="Periplasmic serine endoprotease DegP-like" evidence="6">
        <location>
            <begin position="35"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="300"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="402"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="50499" checksum="012DCAE1F38B9CDD" modified="2006-07-11" version="1">MACSLPSRRFLSALVLLPAATLGACGQAIGTASAASPAPTAQVAAAVPAQAAPPIQKALFNPAVAGSQGGITSLAPLVDAVKGAVVNVEVRARPRRSAAMQRLPPGMAERFGLPPGFGGEGNGPARQGAGSGFIIDASGIVLTNNHVVEDADQVRVKLDDGRAFDAEVMGRDPLTDVALLKLKGAPGNLPAVPLGDSDALRVGDAVMAIGNPFGLASSVSAGILSARARDIQAGPYDEFLQTDAAINPGNSGGPLFNMQGEVVGMNTAIVGGATGIGFAVPSKLIQALLPQLKETGVVRRGWLGLAVQDLTPDLARALGLEAMKGAVVAGVNRGSPGERAGLREEDVITSVNGKPVESAGGLTRAVALLQPDSRVKVNLLRGGKAQSLDVTLGTRPAQNGEQEVLPRNASASAPRRLGVQLSDARDGGAQVVAVEPGSPAERGGLVPGMVLVQVGDQKIASVSDAAQALTAAKPGAALLLRVRMPGSESTLLRAVEVPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX5</accession>
    <name>Q1DDX5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551008.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0887"/>
    <dbReference type="EnsemblBacteria" id="ABF92076">
        <property type="protein sequence ID" value="ABF92076"/>
        <property type="gene ID" value="MXAN_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="41358346"/>
    <dbReference type="KEGG" id="mxa:MXAN_0887"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_3_7"/>
    <dbReference type="OMA" id="NQQGYAG"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="24912" checksum="65E3A07C3DF4C996" modified="2006-07-11" version="1">MAREPAQRELKQERAARTRMDILEAAIHLFARRGFLATTMADLSRAIRMTPGALYWHFPTKEDLLLAAIEELHQRCLRAFQLPGDDRELPAREQFQAICERTHLLLREHREYGIFFAMLAAEAADSNDQVAEAIRDKLALYATTLERLIRHGQQMGEFRQDVDALAAAHSLLGGLLGMLVHQNLFRASVDYDPLYRAVMRIHLAGLVQATGFDCVNASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY1</accession>
    <name>Q1DDY1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551002.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0881"/>
    <dbReference type="EnsemblBacteria" id="ABF91616">
        <property type="protein sequence ID" value="ABF91616"/>
        <property type="gene ID" value="MXAN_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="41358340"/>
    <dbReference type="KEGG" id="mxa:MXAN_0881"/>
    <dbReference type="HOGENOM" id="CLU_1265808_0_0_7"/>
    <dbReference type="OMA" id="YTCTETA"/>
    <dbReference type="OrthoDB" id="2060224at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021655">
        <property type="entry name" value="Put_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11617">
        <property type="entry name" value="Cu-binding_MopE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188531" evidence="1">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="27730" checksum="B9B29B050A252DD2" modified="2006-07-11" version="1">MKTFESRLRVWCGLLLVAGAVGCTVNFPDDVPYTCTETADCGGDGYVCTSLPDNGPRYCCLPDPTEVCNGLDDDCDGLVDNLETACYTGPEGTLDVGLCHAGESICTRDASIACVGQVLPGTEICNGLDDDCDGTADEDFDLKTDPGHCGACNNDCSFLQDCVNGECVRRQELDCANGQDDDGDGFPDCQDRADCDGKSCGPECVCEGGSKTEVSCTNGEDDDGDGLVDCADRADCPTETQCGPLRSDRENDYPRCQVNGVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE20</accession>
    <name>Q1DE20_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550963.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0841"/>
    <dbReference type="EnsemblBacteria" id="ABF89879">
        <property type="protein sequence ID" value="ABF89879"/>
        <property type="gene ID" value="MXAN_0841"/>
    </dbReference>
    <dbReference type="GeneID" id="41358302"/>
    <dbReference type="KEGG" id="mxa:MXAN_0841"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_7"/>
    <dbReference type="OMA" id="NHASMIV"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="73"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="434" mass="47436" checksum="31BB980F24D234F3" modified="2006-07-11" version="1">MDPTRNAFPEKNRNLAVGSARLQEVQKAVHYYVDNHHCDVIGRVFHGMPGREARVSFSPTRRDVRLNAEGPRDVLHFGSYNYSGLNGHPRVVAAAEAALRRYGTTVSGVRLLNGTCELHLELERALAEFLGFEDCVTYSSGYAANLSVLSALCAEGDVVLSDMLNHQSIIDGLKLSGADIRTYRHKSLRSIESTLKKLPYEQRKFIITDGVFSMDGDVADLPGIVALAESYNAFILVDDAHATAAMGPNGRGTPAYFGLQSQVDVLTGSLSKGLPGIGGFAAGSKATIDLLRFGSNGYIFSASLPPPIAAGLLEGIRILQEQPELQERLHHNENYLRAGIRSMGLDCMNSESPIIPILMPAYEKTFELTRLLHLEGIYVNPVGYPAVSKNRTRLRINVSANLTQADLDRFLDALDRCSRKLNLQDAPPLQQTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB0</accession>
    <name>Q1DEB0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550873.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0747"/>
    <dbReference type="EnsemblBacteria" id="ABF88927">
        <property type="protein sequence ID" value="ABF88927"/>
        <property type="gene ID" value="MXAN_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="41358217"/>
    <dbReference type="KEGG" id="mxa:MXAN_0747"/>
    <dbReference type="HOGENOM" id="CLU_1934484_0_0_7"/>
    <dbReference type="OMA" id="TRTWYRG"/>
    <dbReference type="OrthoDB" id="1919041at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13195" checksum="BC6103C55BFFC29E" modified="2006-07-11" version="1">MRPREPHSLNALLLVPALALAALACVAVSARQGTLATAATLTLLLLPVVFRLWTRTWYRGLVLRGVGVFLMGMHVPLLLAGVLAYGRIGCNGGGCPKLYLLGVLVSPIAGVLASVIYWLVGRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL2</accession>
    <name>Q1DEL2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0643"/>
    <dbReference type="EnsemblBacteria" id="ABF85915">
        <property type="protein sequence ID" value="ABF85915"/>
        <property type="gene ID" value="MXAN_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0643"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025061_0_0_7"/>
    <dbReference type="OMA" id="HVRFAPC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF85915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="569" mass="63084" checksum="128B0A5B20726844" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="755" mass="83558" checksum="82038FD6B1B2F62B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF21</accession>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="130" mass="14577" checksum="BB52E2FC54157EAD" modified="2006-07-11" version="1">MGARWRRAAQVGWLAFALCGAAAVVRASTAELPPRERTLNAAERKLVGRAAASQEPEWRRKSRQSFPGDRWSQDDDFGASERQWALDEARRRRVPVTDVLGAIDEELHGQPVLPPRKATASPCKPRPFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF46</accession>
    <name>Q1DF46_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Putative sigma 54 modulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550590.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0457"/>
    <dbReference type="EnsemblBacteria" id="ABF90070">
        <property type="protein sequence ID" value="ABF90070"/>
        <property type="gene ID" value="MXAN_0457"/>
    </dbReference>
    <dbReference type="GeneID" id="41357950"/>
    <dbReference type="KEGG" id="mxa:MXAN_0457"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112793_1_1_7"/>
    <dbReference type="OMA" id="YRGMETS"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="12640" checksum="687544F970C2F765" modified="2006-07-11" version="1">MNRALQITYRGMETSEALSEHIRDHAGKLEQFYDGIVGCHVVVEEPHRHKQHGRHFHVRVDVSVPGRNIVASRDPQARTGHEDAYQAVTEAFDAARRQLQHYADALNTHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFB9</accession>
    <name>Q1DFB9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92488">
        <property type="protein sequence ID" value="ABF92488"/>
        <property type="gene ID" value="MXAN_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0380"/>
    <dbReference type="HOGENOM" id="CLU_3155200_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="48" mass="4890" checksum="AC25B64C907577BE" modified="2006-07-11" version="1">MQTTNLTSPMNPDTLNDTVIGIGVLAPVALLPAPVLPGLPIGGRWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ4</accession>
    <name>Q1DFJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0299"/>
    <dbReference type="EnsemblBacteria" id="ABF86112">
        <property type="protein sequence ID" value="ABF86112"/>
        <property type="gene ID" value="MXAN_0299"/>
    </dbReference>
    <dbReference type="GeneID" id="41357798"/>
    <dbReference type="KEGG" id="mxa:MXAN_0299"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_976000_0_0_7"/>
    <dbReference type="OMA" id="HAVDAVW"/>
    <dbReference type="OrthoDB" id="1355932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="30062" checksum="4B7AE415963D048D" modified="2006-07-11" version="1">MSDCMRDWDVWRLVLPGVSPLEVWNLPVMGRELWELLGAPRVDADRRAGVPEPALAGRLGPALAVALSTLVKRHAVDAVWLSGGLVCLEGFGAMLSSVSTALPCPVYVAEHPLFAPALAGLRLLAPLAPAHPVALDVGQTGIKCVSPTAAPRIFERDAALLPRYFIGMARPPDRRHVKAAVAFIASALRVFSARLPDALCLALPCPLDASLVPGGCTYGWEGHESLVADILQAAMGNEGRGTALVLNDAELATEAARGDSRLANHSRVLCLTLGFGPGGALLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM1</accession>
    <name>Q1DFM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550416.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0271"/>
    <dbReference type="EnsemblBacteria" id="ABF90893">
        <property type="protein sequence ID" value="ABF90893"/>
        <property type="gene ID" value="MXAN_0271"/>
    </dbReference>
    <dbReference type="GeneID" id="41357771"/>
    <dbReference type="KEGG" id="mxa:MXAN_0271"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034925_0_0_7"/>
    <dbReference type="OMA" id="KYARIEF"/>
    <dbReference type="OrthoDB" id="468923at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188685" evidence="2">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="459" mass="47901" checksum="84DA37F2AE6ADD05" modified="2006-07-11" version="1">MKRLFASLLTLSALSLTSACGDDDNTPNNPNPPPTDTTENVSANITQDTTWKAGVTYTLKNYIFVESGTLTIEPGTRILGDQGSALIITRNAKIHAVGTAQAPIVFTSSRPVGSREPGNWGGVVLLGKGRINVAGGENTVEGFFASGNNPLTQYGGGANPNDAHDCGKLNYARIEFAGFELSEDNELNGLTVAGCGSDTDLDYIQVHMGADDGVEFFGGSANLKHAVVTQADDDSLDYDLGYNGKIQFFIAQQNAVVGNFGIEASGNKNDNAATPRSAPEIWNATFIGSGRPSGTSPAQSGMVFNTGAGGKLNNVIVAHFADLAVDVSGTASAALWNAATPELYLRNTFFWNNRGDKVSIPAAPNPTVDAGGNITNPDVSNFNEPERVLASALNNRVVDPQLTDATHLTAPNFMPVAGSPALNPDSAATPPAGFDTSARFVGAVGTTNWLAGWTAFPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFU7</accession>
    <name>Q1DFU7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0194"/>
    <dbReference type="EnsemblBacteria" id="ABF89436">
        <property type="protein sequence ID" value="ABF89436"/>
        <property type="gene ID" value="MXAN_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0194"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031866_1_0_7"/>
    <dbReference type="OMA" id="METQEAY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="422" mass="45727" checksum="866A481F827D18A8" modified="2006-07-11" version="1">MTSKPEDGALNMAGKLSGAYVQTGPSEAFAWMELKARPAETGQRVPVSLALVLDRSGSMNGQKLADARRAATELVQRLKPEDRLAFIDYGTDVRVQPSRRMTEEAREELLTLISGLQDDGSTNISGALDAAANALRPHMREYRVSRAILLSDGQPTTGIVSEPGLLDQVRQLRRDGITVSALGVGRDYQETLMRGMAEQGGGFSGFIDDSARLAEVFSRELDQATSTVARMVELRLDVPPEVQDVEVMGMASFREGNVLKVPLYDMASAQTVRVMAKLTLNTSRTAGALALLNARVHYVDVARDLPTETALQLTAEVTSDLDRVREYLDKEVRVHAVRAMGTQHMVAAAEEMKRGNKAKASSLLDNARTIFGTSADALSGELADVRRSQAALAGASSAEEAQAESRNLLKKSIKNFGQNNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG28</accession>
    <name>Q1DG28_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550259.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0112"/>
    <dbReference type="EnsemblBacteria" id="ABF86038">
        <property type="protein sequence ID" value="ABF86038"/>
        <property type="gene ID" value="MXAN_0112"/>
    </dbReference>
    <dbReference type="GeneID" id="41357617"/>
    <dbReference type="KEGG" id="mxa:MXAN_0112"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102964_1_1_7"/>
    <dbReference type="OMA" id="RTPERDW"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="19325" checksum="26758B578E0BCE27" modified="2006-07-11" version="1">MDTRHVVERALVREARPEDDAVVGELLVDAFLTQYAKKLPEVVYGDERKRELRDVASRRKAATVLVAELDGQVVGTVALFKPGAPGSEAWLPNAADLRGLATAVSHHGTGLAQPLLDAAEARAREWGVDAVCLHVRRGAEGVGRMYQRRGFVREPVGDLDLPTVFLEGYVLRFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG51</accession>
    <name>Q1DG51_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550236.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0089"/>
    <dbReference type="EnsemblBacteria" id="ABF88395">
        <property type="protein sequence ID" value="ABF88395"/>
        <property type="gene ID" value="MXAN_0089"/>
    </dbReference>
    <dbReference type="GeneID" id="41357596"/>
    <dbReference type="KEGG" id="mxa:MXAN_0089"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_4_7"/>
    <dbReference type="OMA" id="KWVPPFA"/>
    <dbReference type="OrthoDB" id="1383885at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23990" checksum="15D9A7443D8C2F19" modified="2006-07-11" version="1">MMTVSAFKWVPPFAQGLVRDLRVRWALEEAGLPYQVKLIDNTVQASPDYRKLQPFGQVPVLEEDGLVLFESGAIVLHIANKCEALLPADSAGRARAVTWLFAALNSIEIVIQPLAEVDLFFAQEEWAKLRRPGVVESLKERLGELAAHLGEREYLEDCFTAGDLMMATVLRILRHTDVLDGFPTLKAYKERCEARPAFQRALAAQMAPFQQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG60</accession>
    <name>Q1DG60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0080"/>
    <dbReference type="EnsemblBacteria" id="ABF91640">
        <property type="protein sequence ID" value="ABF91640"/>
        <property type="gene ID" value="MXAN_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0080"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012617_2_1_7"/>
    <dbReference type="OMA" id="YAQAYLG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="576" mass="61183" checksum="BF3C91FF2A13E1C0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGC9</accession>
    <name>Q1DGC9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CapA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550160.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0010"/>
    <dbReference type="EnsemblBacteria" id="ABF88172">
        <property type="protein sequence ID" value="ABF88172"/>
        <property type="gene ID" value="MXAN_0010"/>
    </dbReference>
    <dbReference type="GeneID" id="41357518"/>
    <dbReference type="KEGG" id="mxa:MXAN_0010"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031776_0_0_7"/>
    <dbReference type="OMA" id="CYAFRSP"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="56377" checksum="90058DD5B9FB0AD1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVR0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92895">
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        <property type="gene ID" value="MXAN_7407"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_7407"/>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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            <dbReference type="EMBL" id="ABF92895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="207" mass="21633" checksum="56F96056A19682CA" modified="2006-07-11" version="1">MARSGRRAPGHVHRAYATEGRLMKANNWKNLAAVAGVMVSVSAGAQESSGSFGSEGQFVISTDASASLGYSTQGSGIGYIFLEPGADYFLKKNLSVGSGLQVRALFGSGDTIAAFGLNARVGYNIPLSDRVSVWPKGQVSLYIGDDILPFANSALPANVTVILEGYAPFLFHVTPHFFVGGGPRLAFGLGDDVEVNFSVASTIGGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW18</accession>
    <name>Q1CW18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">MXAN_7292</name>
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    <organism evidence="1 2">
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92953">
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        <property type="gene ID" value="MXAN_7292"/>
    </dbReference>
    <dbReference type="GeneID" id="41364455"/>
    <dbReference type="KEGG" id="mxa:MXAN_7292"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969182_0_0_7"/>
    <dbReference type="OMA" id="IMIDSPF"/>
    <dbReference type="OrthoDB" id="1058440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="34974" checksum="E1242238C7653107" modified="2006-07-11" version="1">MECLEITKWPLQRLRGWACQPLPVGSLPFMTSVFDLILRRLEQGHPEQLLLLLFGGQTPAFVRMADSSLPQSERRADTVMVVEAGGARFAVDVEIQAQADPHFAARLLDYTVRIHHREKLPVLPVAIYLVPEAEGAPPPYGFECSGLRVLTFDFQVVRLWEVDYLQPALRAATALLPLSVLESRAGPERIAWAESRIRQAPSLSTEERLDLLVVLGTLASRRFGQDRLSQHLRNIMIDSPFWEEQRAKERARAWSQVLRAFVEARGLPHPADVSERLEQLDASSLEALVTKAVTDPDTAATELRAVLTAPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW91</accession>
    <name>Q1CW91_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7219"/>
    <dbReference type="EnsemblBacteria" id="ABF88817">
        <property type="protein sequence ID" value="ABF88817"/>
        <property type="gene ID" value="MXAN_7219"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7219"/>
    <dbReference type="HOGENOM" id="CLU_386766_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="714" mass="78200" checksum="4213639FF2E19834" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD1</accession>
    <name>Q1CWD1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7179</name>
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    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="41364352"/>
    <dbReference type="KEGG" id="mxa:MXAN_7179"/>
    <dbReference type="eggNOG" id="COG4276">
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    <dbReference type="OMA" id="NNVRDMA"/>
    <dbReference type="OrthoDB" id="2023883at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187851" evidence="2">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="21324" checksum="CB7A5C607B81CE03" modified="2006-07-11" version="1">MKTPRRAAPLAALLALGGLGACASRQQAPTAAAKPEAPRAAEPVVRSTEGGFSVAIPGPVSEERRSQETDVGAVTLHTFIAVRPEVDTAYYVSYTDFPAAAVSQADPRDVVARASHGALEALGATGLSARPLVLSGFPGWEVEGVSGPRHLRGRFFLVGPRLYQQLLLHPEGKPPQDADRFFESFQLDPQVAAMLTGERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWT0</accession>
    <name>Q1CWT0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556949.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7030"/>
    <dbReference type="EnsemblBacteria" id="ABF85852">
        <property type="protein sequence ID" value="ABF85852"/>
        <property type="gene ID" value="MXAN_7030"/>
    </dbReference>
    <dbReference type="GeneID" id="41364206"/>
    <dbReference type="KEGG" id="mxa:MXAN_7030"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2012810_0_0_7"/>
    <dbReference type="OMA" id="EAMQRNE"/>
    <dbReference type="OrthoDB" id="2058268at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="123" mass="13346" checksum="F30695E6F1AD0DE9" modified="2006-07-11" version="1">MEAMQRNESAPPRRAWLPWGLLVSAVLLATTGAWAGSRSISALVERNDALTREAAESEARVAELQALREAMSRRLRTLEQQHHAAYAAAVTATAACTTALQPPPAPGKPEPRRLAKAKKQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">MXAN_6940</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_6940"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="33083" checksum="644FBD58444AFBCD" modified="2006-07-11" version="1">MAHEHRQPRQPLPGLLAARLEAGRVQVGELRRGPSMQPRHPLLQRRQPHAQRPQERRRPSQQRGGLIERPRTLLRSAPRQDGAGRDDCVQRRPIQHHRRRILVQPAPVQPRQHGLQRGGHLGTRAQQGPVSPRRAGRGFAQERAQRLQRLGFEQLGFLDVPPALQPLQQRAEGHQHLHVHPRLERAMGGHAIANLEAVRPERGHRPAVPLTRLGQPGIPRRGDARLRQHLPHTQAQCRQHQATHREWDEEGHASQLCQLRPRPARRMRAPLPRLPGERATGWRGAHPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX31</accession>
    <name>Q1CX31_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_6928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6928"/>
    <dbReference type="EnsemblBacteria" id="ABF90414">
        <property type="protein sequence ID" value="ABF90414"/>
        <property type="gene ID" value="MXAN_6928"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6928"/>
    <dbReference type="HOGENOM" id="CLU_2421909_0_0_7"/>
    <dbReference type="OMA" id="PDEIHEF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="105" mass="12214" checksum="D6661A869A1AC4A6" modified="2006-07-11" version="1">MRRRQPTHRAFRGEAMRFKKLGAEDVGESTSRRHMNPDTGEDEINISDQDLAATPPLEEEPDFRDILPDEIHEFRRGDEEEEPLELTAQPGYRIRPIDFDKLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXH1</accession>
    <name>Q1CXH1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6785"/>
    <dbReference type="EnsemblBacteria" id="ABF90545">
        <property type="protein sequence ID" value="ABF90545"/>
        <property type="gene ID" value="MXAN_6785"/>
    </dbReference>
    <dbReference type="GeneID" id="41363975"/>
    <dbReference type="KEGG" id="mxa:MXAN_6785"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020579_0_0_7"/>
    <dbReference type="OMA" id="FIIGPHT"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="600"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="699" mass="73078" checksum="908F013C1DF0154E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM3</accession>
    <name>Q1CXM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556658.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6733"/>
    <dbReference type="EnsemblBacteria" id="ABF86843">
        <property type="protein sequence ID" value="ABF86843"/>
        <property type="gene ID" value="MXAN_6733"/>
    </dbReference>
    <dbReference type="GeneID" id="41363925"/>
    <dbReference type="KEGG" id="mxa:MXAN_6733"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_45_5_7"/>
    <dbReference type="OrthoDB" id="1984516at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="106" mass="11019" checksum="5A3DA14212E14BC9" modified="2006-07-11" version="1">MQSILPLRPEQDVNPRDDSGATALFLAAWKGLSASVSALLGRGANPDLADEGGNTPLHTAARNGHAEVIELLLTGGADARLRNAAGESAADRARQQGHTKLAERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXT6</accession>
    <name>Q1CXT6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556595.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6670"/>
    <dbReference type="EnsemblBacteria" id="ABF85853">
        <property type="protein sequence ID" value="ABF85853"/>
        <property type="gene ID" value="MXAN_6670"/>
    </dbReference>
    <dbReference type="GeneID" id="41363868"/>
    <dbReference type="KEGG" id="mxa:MXAN_6670"/>
    <dbReference type="eggNOG" id="ENOG50316YI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2511107_0_0_7"/>
    <dbReference type="OMA" id="MDPVEAT"/>
    <dbReference type="OrthoDB" id="1936556at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="98" mass="10943" checksum="D9D7411AE8C52CDA" modified="2006-07-11" version="1">MDVTEGIVISLITAMVVGVPLFGLTLRFSLKPLVEAFIRLKETQHGGMEVRLLRERIAHLERVLEAHGLMDDHLSLSLRPGAPERLPAVAPLKDRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ9</accession>
    <name>Q1CXZ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556532.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6606"/>
    <dbReference type="EnsemblBacteria" id="ABF92359">
        <property type="protein sequence ID" value="ABF92359"/>
        <property type="gene ID" value="MXAN_6606"/>
    </dbReference>
    <dbReference type="GeneID" id="41363804"/>
    <dbReference type="KEGG" id="mxa:MXAN_6606"/>
    <dbReference type="eggNOG" id="ENOG5031CRD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051342_1_0_7"/>
    <dbReference type="OMA" id="AYWHVVR"/>
    <dbReference type="OrthoDB" id="1115456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="380" mass="41670" checksum="8389C7A28309699F" modified="2006-07-11" version="1">MSAIPLAVPGPARAGWLVDRRHDLISTGGGLGVSLALVGLHVWGGVSSLLLWWAWVLALDGPHLFATVSRTYLDAREWQTRRRLLLGSLAWFTAGPASFGLSALLGTKLPFALFMTAAALWAYWHVVRQHYGIMVLYQRKSGESLPLDRRFDSVTLYTGLLAPFVAFAVSHPGARKQLGLLGPPTWEPVVAGACFATVLALVVLYAGRQVQRHRAGLKVNGPKLLMMGAAMGLSAVVFWPPFAARMDFIMFAVAVTAFHNVQYHGVVWFYHRNRYHAAGVDPAPFGWAPKVSQRFVIYAVCGVIFTLLYRGLGCGFGAHPGCGGFDLKVPLGAGLTLRNLMECFIWGFALHHYYLDQKIWRVSRDTGLNRDLKLGTSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY42</accession>
    <name>Q1CY42_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556489.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6559"/>
    <dbReference type="EnsemblBacteria" id="ABF89355">
        <property type="protein sequence ID" value="ABF89355"/>
        <property type="gene ID" value="MXAN_6559"/>
    </dbReference>
    <dbReference type="GeneID" id="41363764"/>
    <dbReference type="KEGG" id="mxa:MXAN_6559"/>
    <dbReference type="eggNOG" id="ENOG502ZAX0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738538_0_0_7"/>
    <dbReference type="OMA" id="NGRWFWL"/>
    <dbReference type="OrthoDB" id="1594721at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="17724" checksum="4D51E51AA6585715" modified="2006-07-11" version="1">MQMPALLEEVSRVHHARPPATPAQIAAFEQSVGWRLDPDLRAFYLHCDGADLFGTVDPAFSFFPLAEIRRARVTMRKKDTDKAGPSSWYALCDVRDSNYILLDVSHQLDGRYPIRDGYNEAFPDPAYCRQIARSFSEFLAGALRSNGRWFWLPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYE4</accession>
    <name>Q1CYE4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556387.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6456"/>
    <dbReference type="EnsemblBacteria" id="ABF92748">
        <property type="protein sequence ID" value="ABF92748"/>
        <property type="gene ID" value="MXAN_6456"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_6456"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="MGAKRYL"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
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        <property type="entry name" value="SBP_5"/>
    </dbReference>
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        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR30290"/>
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    </dbReference>
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        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="196"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115143" checksum="11042D9FAA2D580E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF3</accession>
    <name>Q1CYF3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6446"/>
    <dbReference type="EnsemblBacteria" id="ABF90875">
        <property type="protein sequence ID" value="ABF90875"/>
        <property type="gene ID" value="MXAN_6446"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6446"/>
    <dbReference type="eggNOG" id="ENOG502ZZV4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172516_0_0_7"/>
    <dbReference type="OMA" id="ACRELPT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="12604" checksum="2798103A5E97475A" modified="2006-07-11" version="1">MEGVRGLVGCKTELRFRQKDPPELLELQLEPRGQLHPDCYPPELPPPCDVCGRFKLTLPDEPILDAASLPTDRDVFRVGNFATVMVGTERFKEAVQRLELEGITFRELPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU1</accession>
    <name>Q1CYU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Voltage-gated chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556240.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6307"/>
    <dbReference type="EnsemblBacteria" id="ABF87393">
        <property type="protein sequence ID" value="ABF87393"/>
        <property type="gene ID" value="MXAN_6307"/>
    </dbReference>
    <dbReference type="GeneID" id="41363523"/>
    <dbReference type="KEGG" id="mxa:MXAN_6307"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_5_1_7"/>
    <dbReference type="OMA" id="PLTGMMM"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="605"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="677" mass="70581" checksum="2A1074AA5E5F01A5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE2</accession>
    <name>Q1CZE2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556045.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6096"/>
    <dbReference type="EnsemblBacteria" id="ABF91473">
        <property type="protein sequence ID" value="ABF91473"/>
        <property type="gene ID" value="MXAN_6096"/>
    </dbReference>
    <dbReference type="GeneID" id="41363330"/>
    <dbReference type="KEGG" id="mxa:MXAN_6096"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168237_0_0_7"/>
    <dbReference type="OMA" id="PDWVCGE"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="115" mass="12779" checksum="6FE15A409E5AF633" modified="2006-07-11" version="1">MSAPHSKPVECTRCGACCVAPDIAALDKPLGLRCPHLQEDNLCGVYEERPAICRDYQADEVCTLIEAPTLEERVEKYLSLFGLQAEARALREQGCASMRMARRLDTLRRPDGAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZS7</accession>
    <name>Q1CZS7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555910.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5959"/>
    <dbReference type="EnsemblBacteria" id="ABF86133">
        <property type="protein sequence ID" value="ABF86133"/>
        <property type="gene ID" value="MXAN_5959"/>
    </dbReference>
    <dbReference type="GeneID" id="41363198"/>
    <dbReference type="KEGG" id="mxa:MXAN_5959"/>
    <dbReference type="eggNOG" id="COG5379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844197_0_0_7"/>
    <dbReference type="OMA" id="FDFNPRQ"/>
    <dbReference type="OrthoDB" id="1448461at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="36744" checksum="0A92B91334673789" modified="2006-07-11" version="1">MEPGLVSTPPLRLKFAVVREDAALELALVERTRARAVLTVASGGCTLLTLARRHPALELVGFDFNPRQLAHVREKAEGLGRLPLARYSVDAEDAAALNQRGEFEGLFRTLRRFIEEFVAPAHELAAFFAPATTASQRREACARWFASPYWPVAFELALAAPLLNTMFGPAATQHAEPGSYPGYFQAVFERGLQREDAPRNPFLQHVLLGRYLREDAPEYLRAEGPLALTLVQGSLPDVPRLDRFDVISLSNIFDWSEDALVAEWAGVLAREARPGCAVLIRQLNNRRDLRGFFQPAFEFDDALGAELLARDRSLFYERIEVGFRVPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW8</accession>
    <name>Q1CZW8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555869.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5918"/>
    <dbReference type="EnsemblBacteria" id="ABF92309">
        <property type="protein sequence ID" value="ABF92309"/>
        <property type="gene ID" value="MXAN_5918"/>
    </dbReference>
    <dbReference type="GeneID" id="41363156"/>
    <dbReference type="KEGG" id="mxa:MXAN_5918"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127630_0_0_7"/>
    <dbReference type="OMA" id="HAQGEKR"/>
    <dbReference type="OrthoDB" id="1795990at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="23373" checksum="B741EFBED33DB8CF" modified="2006-07-11" version="1">MPGTHTNRWRCRTASARSPRASGANKRRPRVKWEEAAMDAAQEGSMAPRPGWWSRHWRWVLPLGCLGLLASCIGLGVLATYLGFSSLGQSDAHQEAVAIASGDALVQRALGTPIESGLPRRSSVQSRNGVSRAQFSLPLEGPDGKGTLHAQGEKRGDGPWQFSHLIVALSDGTLIDLLRAEPPKRPELPLPAEPPYADEAPEPGEVAPRDAGRDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ0</accession>
    <name>Q1CZZ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555847.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5896"/>
    <dbReference type="EnsemblBacteria" id="ABF86178">
        <property type="protein sequence ID" value="ABF86178"/>
        <property type="gene ID" value="MXAN_5896"/>
    </dbReference>
    <dbReference type="GeneID" id="41363135"/>
    <dbReference type="KEGG" id="mxa:MXAN_5896"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_7"/>
    <dbReference type="OMA" id="ICPGIIE"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="29936" checksum="742CD7D94C8AAA65" modified="2006-07-11" version="1">MATQRIFITGGASGLGKAIAVRFARAGWKVCIGDVNDTRGEEALKELSALAPQAHYLRCDVRREEDLREALDWLTAQWGGVDVVINNAGVAQAGAIEDVSIDDWQWIIDINLLGVVRGCKVFTPAFKKQGHGHIVNVASMAGLLDVPLMSSYNATKAAVVSLSETLHNELAEYGIGVSVVCPSFFKTNLGDSLRTTDPRLGATMARLLERSAITADDIANDVFDAVAERGFYVLPHADGRRTWALKRLLPRELYSWMLRRNTRGMRPGSQPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D068</accession>
    <name>Q1D068_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">agmR</name>
        <name evidence="2" type="ORF">MXAN_5818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555769.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5818"/>
    <dbReference type="EnsemblBacteria" id="ABF92732">
        <property type="protein sequence ID" value="ABF92732"/>
        <property type="gene ID" value="MXAN_5818"/>
    </dbReference>
    <dbReference type="GeneID" id="41363058"/>
    <dbReference type="KEGG" id="mxa:MXAN_5818"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044079_0_0_7"/>
    <dbReference type="OMA" id="DAMMLDM"/>
    <dbReference type="OrthoDB" id="1347467at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="40829" checksum="3FF94341D54A2D91" modified="2006-07-11" version="1">MSTTALSPALAGKRVLICVGSGGVGKTTAAAALALRASVDGRSSLVCTIDPARRLANSLGLTALGNAETRVPATALEPLGVQPRASLYAMMLDMKQTWDELITRVAPPEQRERILSNRFYQSLSTALAGSQEYISMEKLWELRRSSNYELIVLDTPPTAHALDFLDAPNRVLDFLDNDAAKWLLTPALKAGKLGMSLFNRGGYVMRGLAKFTGTEMLQELSNFMLAISSLNEGFRERARGVRQLLEDPNTGFVLVTSPHPERMDEAIHFHKMLKQHRMEVVSLVVNRVHPMPTEALWADAATLTPSRRAKVEETLREQQILAEQDRTGIDQLQAACPGVPIVQVPRFAMDVHDISALWRTGRYLVGDETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C3</accession>
    <name>Q1D0C3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane protein, OMP85 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555714.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5763"/>
    <dbReference type="EnsemblBacteria" id="ABF90663">
        <property type="protein sequence ID" value="ABF90663"/>
        <property type="gene ID" value="MXAN_5763"/>
    </dbReference>
    <dbReference type="GeneID" id="41363006"/>
    <dbReference type="KEGG" id="mxa:MXAN_5763"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276687_0_0_7"/>
    <dbReference type="OMA" id="TQFHFSI"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="538"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1031" mass="111627" checksum="AFC8D177E90A5237" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H4</accession>
    <name>Q1D0H4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein, BMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555663.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5711"/>
    <dbReference type="EnsemblBacteria" id="ABF88487">
        <property type="protein sequence ID" value="ABF88487"/>
        <property type="gene ID" value="MXAN_5711"/>
    </dbReference>
    <dbReference type="GeneID" id="41362956"/>
    <dbReference type="KEGG" id="mxa:MXAN_5711"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_7"/>
    <dbReference type="OMA" id="DASQEWY"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="46"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="41583" checksum="489FC21AF819E23E" modified="2006-07-11" version="1">MMLRLHVLALTALLCACSKQKEEAPPSGAQTPAAGKTEKKALPVGLVIDVGGRGDHSFNDAALRGLELWAAGKRYEGGKYVDATPDEVRQSLPPHLSSDAASFKALAIQPIVLQSKAQEDYVPNLQLLVDQGARLTVGNGYMLANAVRTSAQENPKAQFLLIDSQVLDAQGKAMKLPNVRTVLFKEQEGSFLVGALAGLVTKTNKVGFVGGIEVPLIQRFEVGYRAGVKTTNAQASQALMSVYTGSFNNMAAGKQVAQDLISKGADVLFHAAGADGIGVIQAVKEARAAGKSVYAIGVDSDQSHVAPDAILTSMMKYSDLAVYQAAKDLVDGTFSAGEQVLGLKENGVGMAEVRVDFPGKAEALQKVEALRQRIISGTIQVPAVPADLASFQAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0W7</accession>
    <name>Q1D0W7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555521.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5567"/>
    <dbReference type="EnsemblBacteria" id="ABF87022">
        <property type="protein sequence ID" value="ABF87022"/>
        <property type="gene ID" value="MXAN_5567"/>
    </dbReference>
    <dbReference type="GeneID" id="41362814"/>
    <dbReference type="KEGG" id="mxa:MXAN_5567"/>
    <dbReference type="HOGENOM" id="CLU_1592809_0_0_7"/>
    <dbReference type="OMA" id="MEQYART"/>
    <dbReference type="OrthoDB" id="1681695at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="18822" checksum="35EEF8A3B27A5D1A" modified="2006-07-11" version="1">MRYELLLQTMTPGSPYEAARVDALLSERGVVARPDGVRRWSFKNGDVDIGELREGGQVVATELRVPLSDRPDLMREAVEAAAALASEAGVRLVDPQLGRSLTGNDDAGVLEQYVRTARYAGEVAGVPEAMGAGSYALETEGSRGFQLSTRMVLIAIGIFVVLYLVVDTLVGQLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0X5</accession>
    <name>Q1D0X5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nitrate reductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555513.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5559"/>
    <dbReference type="EnsemblBacteria" id="ABF89143">
        <property type="protein sequence ID" value="ABF89143"/>
        <property type="gene ID" value="MXAN_5559"/>
    </dbReference>
    <dbReference type="GeneID" id="41362807"/>
    <dbReference type="KEGG" id="mxa:MXAN_5559"/>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1353463_0_0_7"/>
    <dbReference type="OMA" id="RWGSAWY"/>
    <dbReference type="OrthoDB" id="1873056at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="8">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="21638" checksum="8A07F29D5E0AADCE" modified="2006-07-11" version="1">MSEALFSAIPYVAAGAAVAGVARRLMARAPASAPSAPTPWTLSGRAVLAGGVIVAFIHLLGLVAPRAMQAFNASPGRLFTLEAVGLIGALLLAWGLVGLTLRRAREGQWSTAALLGLLFAQSCSGLYLAVALRWGSAWYVHVVVPYLRSVLAFQPDASLLAQAPFIVQFHTLFGMVVLALALFIRARPEPITAPLLVTPREETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D107</accession>
    <name>Q1D107_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lipase activator protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipase foldase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipase helper protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Lipase modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lipB</name>
        <name evidence="8" type="synonym">lifO</name>
        <name evidence="10" type="ORF">MXAN_5523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in the folding of the extracellular lipase during its passage through the periplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lipase chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555481.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5523"/>
    <dbReference type="EnsemblBacteria" id="ABF91953">
        <property type="protein sequence ID" value="ABF91953"/>
        <property type="gene ID" value="MXAN_5523"/>
    </dbReference>
    <dbReference type="GeneID" id="41362776"/>
    <dbReference type="KEGG" id="mxa:MXAN_5523"/>
    <dbReference type="eggNOG" id="COG5380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064928_0_0_7"/>
    <dbReference type="OMA" id="QQYIDYK"/>
    <dbReference type="OrthoDB" id="1337848at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00790">
        <property type="entry name" value="Lipase_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004961">
        <property type="entry name" value="Lipase_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03280">
        <property type="entry name" value="Lipase_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="350" mass="38204" checksum="D63AB5B8A0A1C8D2" modified="2006-07-11" version="1">MKNRAVIPVAALCALLGAGVFSWWKARATPTPPGPAVAAVSPPMPSAPRVGTPAPQRAVPTASPTDTTSAAPTLPPMPGSLQDTEEDGLAQVDASGHLVVSADLRRLFDYYLSAMGEEGLPVIRERILASLRAKNLPAAAMEEAVRVLDDYLAYRDAARTFAANQRGAELDVGARLQSLRELRREHLGPWAEGLFGDEERVDAVSVERMKLQQDTTLSPEARERRIAALDEQLPAEYRASRDEALRPLRQQAVERELVESGASAEDLRQHRLATVGAEATERLEAMDREEAEWKRRLAEFRSRREALGQSEPNPAARQAAVQRLLFDSFTPEERLRVEALDAIDAAAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D188</accession>
    <name>Q1D188_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_5442</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5442"/>
    <dbReference type="EnsemblBacteria" id="ABF91018">
        <property type="protein sequence ID" value="ABF91018"/>
        <property type="gene ID" value="MXAN_5442"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5442"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008590_3_0_7"/>
    <dbReference type="OMA" id="TFDAENM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FTP" evidence="12">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="10">
        <location>
            <begin position="317"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="11">
        <location>
            <begin position="398"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF91018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="567" mass="60343" checksum="44C00FA3B05297F7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D192</accession>
    <name>Q1D192_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5436"/>
    <dbReference type="EnsemblBacteria" id="ABF85845">
        <property type="protein sequence ID" value="ABF85845"/>
        <property type="gene ID" value="MXAN_5436"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5436"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_21_2_7"/>
    <dbReference type="OMA" id="RIMREDN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="26495" checksum="91B9B4D27D205949" modified="2006-07-11" version="1">MSETVRTQQFSAQGDPGRNDEPAPAPWTPEMWWKGCPMSASDASYYAWASRPESAREAKDDSLTKVVATVHEASRRRYGSPRVFQELKARGSRLSRKRVARLMRQKRLRARPRRRFVKTTDSAHPHPIAPNVLARDFFADKPNSKWVGDITYVWTAEGWLYLAVVLDLFSRKVVGWAMSDPIDRQLVLAALSMALLNRPAQDLHHSDRGSQGGFNGSSQHSTLRSCDGEQQESTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1E0</accession>
    <name>Q1D1E0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90816">
        <property type="protein sequence ID" value="ABF90816"/>
        <property type="gene ID" value="MXAN_5386"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5386"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_0_0_7"/>
    <dbReference type="OMA" id="HQPPISL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="115"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="41762" checksum="EAA8B9D0D6B883A0" modified="2006-07-11" version="1">MQGWATNRTWSCDREGRSMQVLGSKAQGARLERMKASPRFKDGMFHNTSLVTQGLKKGTAVSTMKEFICGGQRRVPTGVLPIVNPLEQWLLPVQGGLRATWLGHSTVLLEVDGKRVLTDPVWGERISPLPFTGPKRFHPAPVTIGQLPPLHAVVISHDHYDHLDYPTILQLIPLGVPFVTSLGVGAHLEAWGVPPERITELDWWESAEVGGLTFTAAPSQHFSGRSVADRNRTAWSSIVVRGPHHAVFFSGDTGLTQEYVEIRQRLGPFDLIMLEVGAWDPAWGDIHLGPENALQAHDLLGGGAFLPVHWGTFNLAIHSWDEPAETLVKLAPTNAPLIMPRLGQPIEPLQVQSIDPWWREVDQTETEPAPAEAVTEPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I8</accession>
    <name>Q1D1I8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555300.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5335"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86198">
        <property type="protein sequence ID" value="ABF86198"/>
        <property type="gene ID" value="MXAN_5335"/>
    </dbReference>
    <dbReference type="GeneID" id="41362604"/>
    <dbReference type="KEGG" id="mxa:MXAN_5335"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_7"/>
    <dbReference type="OMA" id="MVNTDAV"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="30681" checksum="D88756FC1CDEAD05" modified="2006-07-11" version="1">MHAPFVSVVIPAYNEGQRLPRFVAELTRVFLERSAPPVEFVVVDDGSAPEHAELQRASVEAAQARLATEGARHQFTYVAAPRNQGKGSAIRLGWRHASAGVTWLAFLDADGAINAEEFHRLVALSASEMARNVDLLAGSRILMAGRRVVRNLHRHLQGRIFATLTDANFKLHFYDTQCGVKFVRADILRPLLDVLQEQRWLLDVELLVLLKRQGARFLEVPIDWEDFGGSKVIPGLDAARMFWGLLQLRRRLEHVSLPTHRDALPEGEPHAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D213</accession>
    <name>Q1D213_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555128.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5157"/>
    <dbReference type="TCDB" id="2.A.78.2.3">
        <property type="family name" value="the branched chain amino acid exporter (liv-e) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87446">
        <property type="protein sequence ID" value="ABF87446"/>
        <property type="gene ID" value="MXAN_5157"/>
    </dbReference>
    <dbReference type="GeneID" id="41362439"/>
    <dbReference type="KEGG" id="mxa:MXAN_5157"/>
    <dbReference type="eggNOG" id="ENOG5032T1U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159912_0_0_7"/>
    <dbReference type="OMA" id="WRRAPFV"/>
    <dbReference type="OrthoDB" id="1965661at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="10299" checksum="0499E2331FE15080" modified="2006-07-11" version="1">MTLLPILVLAAGTYAFRLAGPLLSQRMQVSARVQGLLSLSAIALLTALVATATLTSNGGFSGWARPAGVLAGAVLAWRRLPFVVVVVGAAGVTALLRMAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D281</accession>
    <name>Q1D281_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555062.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5088"/>
    <dbReference type="EnsemblBacteria" id="ABF87812">
        <property type="protein sequence ID" value="ABF87812"/>
        <property type="gene ID" value="MXAN_5088"/>
    </dbReference>
    <dbReference type="GeneID" id="41362372"/>
    <dbReference type="KEGG" id="mxa:MXAN_5088"/>
    <dbReference type="eggNOG" id="ENOG5031DA5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162623_0_0_7"/>
    <dbReference type="OMA" id="YERHLQG"/>
    <dbReference type="OrthoDB" id="2045790at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13482" checksum="B5FA863A4D85C899" modified="2006-07-11" version="1">MADSADPKYLDKRTAERYVRSGQLDEAEYERHLQGLPDVAEKSVPVETLMLDDADDFDDEEDDFEDEGDDTSDDSDEAETSAAAESTDGDTAEADDAESDDEAESDDEAATASNETSDDEGPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D294</accession>
    <name>Q1D294_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="2">RPPK</shortName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="2">P-Rib-PP synthase</shortName>
            <shortName evidence="2">PRPP synthase</shortName>
            <shortName evidence="2">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">prs</name>
        <name evidence="4" type="ORF">MXAN_5075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555049.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5075"/>
    <dbReference type="EnsemblBacteria" id="ABF90710">
        <property type="protein sequence ID" value="ABF90710"/>
        <property type="gene ID" value="MXAN_5075"/>
    </dbReference>
    <dbReference type="GeneID" id="41362359"/>
    <dbReference type="KEGG" id="mxa:MXAN_5075"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_7"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="34277" checksum="4B19BB36A37A99CD" modified="2006-07-11" version="1">MQPRDFKVFAGNSNPGLAHRICEYLKRPLGKAEVGRFSDGEIHVEIGENVRGHDVFILQSTCPPANDHLMELLIMCDALKRASAGSITAVIPYYGYARQDRKVAPRTPITAKLIADLLESAGAGRVVSMDMHAGQIQGFFNIPSDHLYGSPVFLEDLRKRFPESQELVIVSPDAGGVERARAYSKRLNTGLAIIDKRRPRPNASEVMNLIGDVSGKDAVLVDDMVDTAGTLAQAAAALKAKGARRVVAYAVHPILSGPAIQRIQDSVLEEVVFTDTVPLSPAAQACSKIRLLTTERLFGEAIARIHRADSLSSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L2</accession>
    <name>Q1D2L2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554933.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4955"/>
    <dbReference type="EnsemblBacteria" id="ABF86002">
        <property type="protein sequence ID" value="ABF86002"/>
        <property type="gene ID" value="MXAN_4955"/>
    </dbReference>
    <dbReference type="GeneID" id="41362240"/>
    <dbReference type="KEGG" id="mxa:MXAN_4955"/>
    <dbReference type="eggNOG" id="COG3220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064263_0_0_7"/>
    <dbReference type="OMA" id="EWDTDVP"/>
    <dbReference type="OrthoDB" id="1602134at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="281" mass="31421" checksum="31135095529B3979" modified="2006-07-11" version="1">MVTYAQRHGLKPLGAGIGLRRRFYAELPRTERTLDWVEIIPENFLSLGGRSQRALDACAERWPVLPHGVGLNIGGPDALDDDYVRGLAALVKRVDAPFFSDHLCFSRLDGVYLHDLLPLPFSEAAVEHVVPRVREVMDRVGRPFLLENPSYYARMPGGTLREADFLRRVVEQADCGLLLDVNNVYVNARNHGYDARAFVDALPLERVVQIHLAGHTCYPDVIVDTHGDRVCDDVWSLYRYVLARTGPVATLVEWDQDLPSLDAVLDEADIARASLREVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M2</accession>
    <name>Q1D2M2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554923.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87245">
        <property type="protein sequence ID" value="ABF87245"/>
        <property type="gene ID" value="MXAN_4945"/>
    </dbReference>
    <dbReference type="GeneID" id="41362230"/>
    <dbReference type="KEGG" id="mxa:MXAN_4945"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_0_0_7"/>
    <dbReference type="OMA" id="GNTDCYQ"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="46"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="38887" checksum="04FAD76A0B0185CA" modified="2006-07-11" version="1">MKARPIDNPPNPWASTAVEYLDEIPPSKLEVFEDHSRQVLSHNDSPDVGFSWSVNPYRGCLHACAYCYARPTHQYLDMGAGTDFETKLVVKPRAPELLREAFEKPSWKGETVVFSGVTDCYQPLEASLRLTRGCLEVCAEYRNPVGIITKGVLVERDLDVLQRLARDARLWVSISLPFHNAELARAMEPYAASPMRRLLTIRRLTEAGIDVAVSVAPIIPGLNDEDIHRVLAAAREAGATRAHHILVRLPGPVKDVFAERLRAKLPLRAERVLHRIRETRGGELNDSRFKHRMRGGGLYAETIHRLFHTAARKVGIRASYITEDAPDTFRRPERKPPPTPQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D329</accession>
    <name>Q1D329_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554769.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4782"/>
    <dbReference type="EnsemblBacteria" id="ABF87353">
        <property type="protein sequence ID" value="ABF87353"/>
        <property type="gene ID" value="MXAN_4782"/>
    </dbReference>
    <dbReference type="GeneID" id="41362081"/>
    <dbReference type="KEGG" id="mxa:MXAN_4782"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_2_7"/>
    <dbReference type="OMA" id="WYEPTLN"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="29166" checksum="0F641E2A77E8ACC9" modified="2006-07-11" version="1">MTPFLFMLVVLGFSVGAGLLGSLLGIGGGLILIPVLTLLLKVDIQYAVGASIVSVIATSSGAAAAYVRDRMANTRVAMFLELATTAGALSGAFMSGLVGGRGVYLVFGGVMAWSALVMLRRMRASAETPVPADALADRLALHGSYWDESQGREVSYRVTRPLTGLGLMYVAGTVSGMLGIGSGALKVPAMDLAMRLPLKVSTATSNFMIGVTAAASAGVYFARGNIDPFIAGPVCVGVTLGAWLGSRHLMARVNSTWLRALFVGVLLWVAFEMLRKGWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D348</accession>
    <name>Q1D348_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha subunit</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ORF">MXAN_4763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554750.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4763"/>
    <dbReference type="EnsemblBacteria" id="ABF87108">
        <property type="protein sequence ID" value="ABF87108"/>
        <property type="gene ID" value="MXAN_4763"/>
    </dbReference>
    <dbReference type="GeneID" id="41362062"/>
    <dbReference type="KEGG" id="mxa:MXAN_4763"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_7"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="23185" checksum="B24425E70C9DB362" modified="2006-07-11" version="1">MFTGLIQDLGRVERVIPGGMTDLWIHTSLGAAAFELGESIAVNGACLTVVERTGDSFRVQAAPETLRRTTLGSVKPGDQVNLERALALGDRLGGHLVSGHVDAVSEVLETYPEGGSWVMGFRLPEELAPYFIEKGSVAIDGISLTVNTVEADRFRVQLIPETQERTTLKARGVGSKVNLEADQIGKYVARLFALQRGQGAPGGRGGLTAAAIAAAGFGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3G5</accession>
    <name>Q1D3G5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554634.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4642"/>
    <dbReference type="EnsemblBacteria" id="ABF86784">
        <property type="protein sequence ID" value="ABF86784"/>
        <property type="gene ID" value="MXAN_4642"/>
    </dbReference>
    <dbReference type="GeneID" id="41361942"/>
    <dbReference type="KEGG" id="mxa:MXAN_4642"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_7"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="26324" checksum="92D8E9ACBF4F6DF2" modified="2006-07-11" version="1">MKPRKERLDVLVVERGLAESRTKAQALILAGQVVVGDQRVDKPGTLIPQEAELRLKGEVLPYVSRGGLKLKGAIDRFGLDVRGKVAADIGASTGGFTDCLLQHGATRVHAIDVGYGQLHEKLRTDPRVRSRERVNARYLTEEDLPETVGVVVIDVSFISLTQVLPSVLTYLAPGGLLVALVKPQFEVGPDRVGKGGVVRDVAARQDAIDTVTAFVREQGLEVLGLMDSTVPGPAGNVEALLVASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D432</accession>
    <name>Q1D432_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554419.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4420"/>
    <dbReference type="EnsemblBacteria" id="ABF87658">
        <property type="protein sequence ID" value="ABF87658"/>
        <property type="gene ID" value="MXAN_4420"/>
    </dbReference>
    <dbReference type="GeneID" id="41361733"/>
    <dbReference type="KEGG" id="mxa:MXAN_4420"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1904558_0_0_7"/>
    <dbReference type="OMA" id="GWVAGGN"/>
    <dbReference type="OrthoDB" id="2035522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13327" checksum="C67B7304BED2F450" modified="2006-07-11" version="1">MSLPTRDLARAFRFYRQGLGFALMAGTEGDAMPEPVHFRLNAGVSLMLIPTGGFGWVAGGNRVAEPGVSECILGLSLETEAQVDALIARAREAGAEVPAPPGKQPWGYSGTFKDPDGHVWMLDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4J0</accession>
    <name>Q1D4J0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asp_Arg_Hydrox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4258"/>
    <dbReference type="EnsemblBacteria" id="ABF93023">
        <property type="protein sequence ID" value="ABF93023"/>
        <property type="gene ID" value="MXAN_4258"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4258"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2936773_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="1">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="60" mass="7077" checksum="D10898F994D494C4" modified="2006-07-11" version="1">MAFFLGGERVVLQPGECWYLDFNRPHRVDNPSDTDRVHRVLDCDVNDWLRDVFTRAVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q6</accession>
    <name>Q1D4Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554195.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4192"/>
    <dbReference type="EnsemblBacteria" id="ABF92179">
        <property type="protein sequence ID" value="ABF92179"/>
        <property type="gene ID" value="MXAN_4192"/>
    </dbReference>
    <dbReference type="GeneID" id="41361509"/>
    <dbReference type="KEGG" id="mxa:MXAN_4192"/>
    <dbReference type="eggNOG" id="COG2977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082087_0_0_7"/>
    <dbReference type="OMA" id="FANFAQY"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="28355" checksum="EABF9B2EB27F0E41" modified="2006-07-11" version="1">MTGSDHHDPLGLESSATVSLGMVRHGVPVPAVLACVHQESAAAINDAQLALLHPNERVRLEGFRADSRRLGFFLGRYAAKRALGGLGIQVPMHAVEIAPGVFEHPVVKGAGGDSPVVSLSHARSVAAAVACGPEHIVGVDVEQLSPERTDVFESVMPQRELAMVRHAPGGGELAANVIWTMKEALSKALRCGLTAPFEVLEVDAFEGHVAGGYGCLFRNFAQYRARAWVLGGYVLAVVSPKHSLLHVTPADLERIRQVFGRDVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D524</accession>
    <name>Q1D524_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554078.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D524">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4071"/>
    <dbReference type="EnsemblBacteria" id="ABF88517">
        <property type="protein sequence ID" value="ABF88517"/>
        <property type="gene ID" value="MXAN_4071"/>
    </dbReference>
    <dbReference type="GeneID" id="41361401"/>
    <dbReference type="KEGG" id="mxa:MXAN_4071"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642077_0_0_7"/>
    <dbReference type="OMA" id="VAFQDRP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="237"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="47952" checksum="2AC6737BDBD1702E" modified="2006-07-11" version="1">MDSQLALSEETPANDLRARVRKVLERRKLTDSVSAEQAAASWEQDRFVARARALFYARMMFLTLGLLILAVPAWSGYFGLTGPFSFVGYFAMLLYSVANLLVIDHPKAGRWVTYITLCLDVTISVVLIAKPHVGGGLQSPLLATQLLFTTLFAILFPKPLAILPPLLALPITTRLDLLLNRSVTAVELLTLLWYLALNFIIVYVLVYLNEREAAAHREVVSLQGDLKELAVVEERNRMAREIHDGLGASLSSMIIQSEYILNLAREEGLREEIRELKLTAEESIEELRRSLRMMREDFELAQGLEDYAKTFRERTGLDIRFERTGLQRKLDPDVQLALFRILQESLSNAVKHAEAKGVQVRLDFSEDRVNLVVRDDGKGFDPSRTPRGHYGLLNMRERAMKLGGQLIVDSSPGAGAQVAFSLPCRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D534</accession>
    <name>Q1D534_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554068.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4061"/>
    <dbReference type="EnsemblBacteria" id="ABF92593">
        <property type="protein sequence ID" value="ABF92593"/>
        <property type="gene ID" value="MXAN_4061"/>
    </dbReference>
    <dbReference type="GeneID" id="41361391"/>
    <dbReference type="KEGG" id="mxa:MXAN_4061"/>
    <dbReference type="HOGENOM" id="CLU_896334_0_0_7"/>
    <dbReference type="OMA" id="SWHIERT"/>
    <dbReference type="OrthoDB" id="1900845at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188245" evidence="1">
        <location>
            <begin position="20"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="34132" checksum="F91411383C07CFE9" modified="2006-07-11" version="1">MQKLSLAACALAMLIAACGESSSTGPYTPIRATEGVMRLPLVSTAPNGVQYRLVGATFVITGTESLTITDTSPDTLKVPLVPGTYSIQLEGDWHVERVGTPSEIVPVQLISPNPMAFSLAERDMREIRFLFKLPADGNANVGITVDEGGWITGTMRFTDHSPRDPPSEYAELVGQEVPFTISFEFAYLSRNYWRGLSVATNELVVQFGGPYSALLHDHIARYLSGDTARFELNRGESNLIYFDNFTTMGMSTTGNTPYHLQMTGRHLFRGVLDSEQIPVSQPFPFTAEVTLQRYDTSEGMLRGVATGTGTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D572</accession>
    <name>Q1D572_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554031.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4022"/>
    <dbReference type="EnsemblBacteria" id="ABF91146">
        <property type="protein sequence ID" value="ABF91146"/>
        <property type="gene ID" value="MXAN_4022"/>
    </dbReference>
    <dbReference type="GeneID" id="41361353"/>
    <dbReference type="KEGG" id="mxa:MXAN_4022"/>
    <dbReference type="HOGENOM" id="CLU_507904_0_0_7"/>
    <dbReference type="OMA" id="VPGWPRP"/>
    <dbReference type="OrthoDB" id="837583at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="56912" checksum="F05C72CC5A483B73" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D576</accession>
    <name>Q1D576_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554027.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4017"/>
    <dbReference type="EnsemblBacteria" id="ABF85881">
        <property type="protein sequence ID" value="ABF85881"/>
        <property type="gene ID" value="MXAN_4017"/>
    </dbReference>
    <dbReference type="GeneID" id="41361349"/>
    <dbReference type="KEGG" id="mxa:MXAN_4017"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019252_0_0_7"/>
    <dbReference type="OMA" id="HIGRYRI"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="643" mass="69409" checksum="D61816322BF5C7FF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5B9</accession>
    <name>Q1D5B9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553984.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3974"/>
    <dbReference type="EnsemblBacteria" id="ABF87556">
        <property type="protein sequence ID" value="ABF87556"/>
        <property type="gene ID" value="MXAN_3974"/>
    </dbReference>
    <dbReference type="GeneID" id="41361306"/>
    <dbReference type="KEGG" id="mxa:MXAN_3974"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024627_0_0_7"/>
    <dbReference type="OMA" id="HGIVTGF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="326"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="464"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="700" mass="76315" checksum="496CBBC1071284E7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5F9</accession>
    <name>Q1D5F9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfaD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3934"/>
    <dbReference type="EnsemblBacteria" id="ABF87992">
        <property type="protein sequence ID" value="ABF87992"/>
        <property type="gene ID" value="MXAN_3934"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3934"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040029_0_0_7"/>
    <dbReference type="OMA" id="NNPKRKM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04742">
        <property type="entry name" value="NPD_FabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014179">
        <property type="entry name" value="PfaD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02814">
        <property type="entry name" value="pfaD_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="51"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="53251" checksum="3ACE164302B547BD" modified="2006-07-11" version="1">MSERASDCLRGLTLHAHFMNTPTLNAGLTITAQSLGSSTFRRRFGLAYSYVSGAMYRGIASAPLVARMGKAGFMGFFGTGGCSVEEIGRAIDEIQSQLTKGEPFGMNLLASHGESSLELETVKLYLARGVRNVEAAAFTQATPSLVFYRVKGLRQDAQGRVVCDNRIMAKLSRPEVAEVFMSPPPRRLVEQLLRDAMITPEQAAMAERVPLSHDICVEADSGGHTDGAIPTIILPTLLRLRDRLVSRYGYEEPICMGQAGGIGTPEAAAAAFIMGADFILTGSINQCTVESGMSSDAKLLLQEMGVQDTDYAPAGDMFEMGAKVQVLKKGVFFPARANKLYALYTHYDSVDDIPEKVRKQLESSFFKKSLSQVWEDTKVYLRRKGQQATIDKAEAHPKQKLALIFRWYFAYSTRLAFAGTGEDRVNYQVHTGPALGAFNQWVKGTELESFSNRHADVIAMKLMTEAAEYLNRQYPRLAGQEGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5M5</accession>
    <name>Q1D5M5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctaD</name>
        <name evidence="10" type="ORF">MXAN_3868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553878.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3868"/>
    <dbReference type="EnsemblBacteria" id="ABF92413">
        <property type="protein sequence ID" value="ABF92413"/>
        <property type="gene ID" value="MXAN_3868"/>
    </dbReference>
    <dbReference type="GeneID" id="41361201"/>
    <dbReference type="KEGG" id="mxa:MXAN_3868"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_7"/>
    <dbReference type="OMA" id="NPWGSEG"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="60093" checksum="7004356B797FBB2D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5M8</accession>
    <name>Q1D5M8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553875.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3865"/>
    <dbReference type="EnsemblBacteria" id="ABF91514">
        <property type="protein sequence ID" value="ABF91514"/>
        <property type="gene ID" value="MXAN_3865"/>
    </dbReference>
    <dbReference type="GeneID" id="41361198"/>
    <dbReference type="KEGG" id="mxa:MXAN_3865"/>
    <dbReference type="HOGENOM" id="CLU_1459837_0_0_7"/>
    <dbReference type="OMA" id="HLAFGAC"/>
    <dbReference type="OrthoDB" id="2066483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="19163" checksum="AA0B6B387C031FC3" modified="2006-07-11" version="1">MDRTRQRELQAKHADAVAHWSLVRDVLIAGGLVGTLGAWVMAALALLLGSITQGDLWYAPRLVGGVVFRDAPAGTAAVVLGFALHFATAGGLATAFAMLVPRGGSALTAVMLGLLAGLTLQAVMPVLVVPWAAPPLERAGPPIAAFLLLHLVFGACLGVLTPVRKALLLLDAKRRGVRALPVPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V6</accession>
    <name>Q1D5V6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553798.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3785"/>
    <dbReference type="EnsemblBacteria" id="ABF92773">
        <property type="protein sequence ID" value="ABF92773"/>
        <property type="gene ID" value="MXAN_3785"/>
    </dbReference>
    <dbReference type="GeneID" id="41361117"/>
    <dbReference type="KEGG" id="mxa:MXAN_3785"/>
    <dbReference type="HOGENOM" id="CLU_1560366_0_0_7"/>
    <dbReference type="OMA" id="LHTRLTH"/>
    <dbReference type="OrthoDB" id="1783374at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="18479" checksum="D083BB2586BED2DC" modified="2006-07-11" version="1">MSSFLFDDNGFQDVPNRESSTDLTAADDRTLRWAAPPLDAAMLDALVCYQQTYLAQASGQGTETLAKAHTEALAASGLDPKTAEQGSALLRAFGGRRWAVRKLQDKLGQLQGGAADELQGRIQDELAKQERETNALARRYGEDALVLLRAREAELVDLHTRLTHLLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D679</accession>
    <name>Q1D679_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553675.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90154">
        <property type="protein sequence ID" value="ABF90154"/>
        <property type="gene ID" value="MXAN_3657"/>
    </dbReference>
    <dbReference type="GeneID" id="41360993"/>
    <dbReference type="KEGG" id="mxa:MXAN_3657"/>
    <dbReference type="HOGENOM" id="CLU_1174414_0_0_7"/>
    <dbReference type="OrthoDB" id="2112996at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25797" checksum="1F22618B0B4E5805" modified="2006-07-11" version="1">MFHFLATRVVQLDEIKVRFEAANEAETFGWFVEHFERIQDRAQQQNQPAVEIHLATGLVRADTLAPASPWILVVDGDLEVASDIDLSTQPYDISLFVVLGSVHSKNLRFSGSACCYVTKSVELAGGCFGDHGDEAAELHTIRLKARVLMLDGNTGVNAQHLDAVVFASKGWGLPRHFTDDDVTADFFVAEALDEDGGIDEGAVWELMTSGKDPFQPGALAALSARRVDAETRLKPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D769</accession>
    <name>RS3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">MXAN_3305</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002633602.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D769"/>
    <dbReference type="SMR" id="Q1D769"/>
    <dbReference type="STRING" id="246197.MXAN_3305"/>
    <dbReference type="EnsemblBacteria" id="ABF91094">
        <property type="protein sequence ID" value="ABF91094"/>
        <property type="gene ID" value="MXAN_3305"/>
    </dbReference>
    <dbReference type="GeneID" id="41360658"/>
    <dbReference type="KEGG" id="mxa:MXAN_3305"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_7"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000293837" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <sequence length="220" mass="24801" checksum="A08B50ECDB7F5FB1" modified="2006-07-11" version="1">MGQKVHPIGFRLGVIKTWDSKWFEHKNYAQWLHEDIRIREFVKKSLNHAGVSKVEIERAANKVKVNVHTARPGIVIGKRGAGIETVKKDLQQFTKNEVFLNIVEVRKAETDAQLVAENIATQLERRIAFRRAMKKALQTAMKFGAKGIRVACSGRLGGAEMARYEWYREGRVPLHTLRADIDYGFAEAKTTYGKIGCKVWVCKGEVLPGKGGQAPMPSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7I3</accession>
    <name>Q1D7I3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553236.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3189"/>
    <dbReference type="EnsemblBacteria" id="ABF87618">
        <property type="protein sequence ID" value="ABF87618"/>
        <property type="gene ID" value="MXAN_3189"/>
    </dbReference>
    <dbReference type="GeneID" id="41360544"/>
    <dbReference type="KEGG" id="mxa:MXAN_3189"/>
    <dbReference type="eggNOG" id="COG2921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161438_1_2_7"/>
    <dbReference type="OMA" id="IEYPSVY"/>
    <dbReference type="OrthoDB" id="2028648at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007454">
        <property type="entry name" value="UPF0250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38036">
        <property type="entry name" value="PTHR38036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04359">
        <property type="entry name" value="DUF493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="SSF117991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="101" mass="11376" checksum="AE1781797AA45E70" modified="2006-07-11" version="1">MTKEDAGSPPAGEGEKTPLIEYPSVYTFKVMGAQGAGFVEHVRELFKRFLGTELSPDSIREQPSSKGKYVSLSVSVYLLSEEQRRAIYDGLHKDERVIYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J8</accession>
    <name>Q1D7J8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hflC</name>
        <name evidence="4" type="ORF">MXAN_3172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553221.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3172"/>
    <dbReference type="MEROPS" id="I87.001"/>
    <dbReference type="EnsemblBacteria" id="ABF92370">
        <property type="protein sequence ID" value="ABF92370"/>
        <property type="gene ID" value="MXAN_3172"/>
    </dbReference>
    <dbReference type="GeneID" id="41360530"/>
    <dbReference type="KEGG" id="mxa:MXAN_3172"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059167_1_1_7"/>
    <dbReference type="OMA" id="DFFAFYR"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01932">
        <property type="entry name" value="hflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="313" mass="36152" checksum="97E2F3BE32520BA5" modified="2006-07-11" version="1">MSRLVIPLGVLAVLAVVLGFSATYTLSEHEQAVITRFGEPKGASVVDPGLHFKMPFVDTVNRFDKRWLDWRGDPNQIPTKDKKYIWVDTFGRWRIVDPLRFFQRLRDERNAQSRLDDIIDGETRNTIASFALIEAVRSTNRPFEDDEYTAETERAESLEQVAQGRDKLTRQIRLRAAEIVKEFGVELVDVQIRRINYVDEVQVKVFERMISERKRIAERSRSEGMGRAAEVRGQRERDLKEIRSAAYRKAQDVTGAADAEATKIYAEAFGRDPEFYQFMRTLEAYPDVVDSSTSLFLGGESEFYRYLRSSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L8</accession>
    <name>Q1D7L8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553202.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3152"/>
    <dbReference type="EnsemblBacteria" id="ABF91792">
        <property type="protein sequence ID" value="ABF91792"/>
        <property type="gene ID" value="MXAN_3152"/>
    </dbReference>
    <dbReference type="GeneID" id="41360511"/>
    <dbReference type="KEGG" id="mxa:MXAN_3152"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_2_7"/>
    <dbReference type="OMA" id="QVAWDAD"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14259" checksum="84BEBF946E1DF49E" modified="2006-07-11" version="1">MPVTLMNPEGMMKPDVYRKVAVATGSRQVHIAGQVAYDADGQLVARGDLAGQVAQAYRNVAIALAAAGATFNDVVRLTIYVVDWKHERMPDFLAGIEQVSKELNIVPAPASLIGVSVLFEPGVLVEIEATAVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Q6</accession>
    <name>Q1D7Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553164.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3114"/>
    <dbReference type="EnsemblBacteria" id="ABF88281">
        <property type="protein sequence ID" value="ABF88281"/>
        <property type="gene ID" value="MXAN_3114"/>
    </dbReference>
    <dbReference type="GeneID" id="41360475"/>
    <dbReference type="KEGG" id="mxa:MXAN_3114"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1554350_0_0_7"/>
    <dbReference type="OMA" id="CHRWVSS"/>
    <dbReference type="OrthoDB" id="1328930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="19179" checksum="B844B32D8481314C" modified="2006-07-11" version="1">MNAAAANWQTLENVDVECTHCGIRMTQQPGTRVRYFRCSGCHRWVSSVYSDVFRADAKVRTHPVKDTGAQDEQFIEVKDRLDRWLSALEEQDPYRLLGVSPLDSADTVRARYHALAMEQHPDRGGSAEKMRELNAAYERILRHRQRKRQEALSAGAPVASASVLPARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D891</accession>
    <name>Q1D891_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552981.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2921"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88741">
        <property type="protein sequence ID" value="ABF88741"/>
        <property type="gene ID" value="MXAN_2921"/>
    </dbReference>
    <dbReference type="GeneID" id="41360289"/>
    <dbReference type="KEGG" id="mxa:MXAN_2921"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041001_0_0_7"/>
    <dbReference type="OMA" id="QLHICYC"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="15"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="42169" checksum="91F561C2205D3C8A" modified="2006-07-11" version="1">MKVALVHDWLVTHRGGERVLDALCEVLPDADIYTLIHKPGSQSPAIESRRIFTSFLQHIPGIHARYRHFLPLMPKAIESLQLQGKYDLVLSSSHCVAKGLRTPRGTPHLSYVHAPMRYMWDLFDDYFGPGRTGLPVRAAAHAVRPWLRRWDRRTAAGVDRFIANSRHIATKVQRFWGREASVIHPPVSLERFAQVPLEGGGQGGYFLWLGAFAPYKRLDVALEAFRSLDAQLWVVGAGQEAARLSAGSLPENIRFLGNVLDASLPALYRDARALIFTPEEDFGITPLESQAAGRPVIAYGKGGALETVTARTGMFFSEQTPESLAAAVRRFDEWEAGFRPEAARAQAERFGRAHFQSAILREIHAVLGEVLPDSPGPAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D2</accession>
    <name>Q1D8D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sphingosine-1-phosphate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552941.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2880"/>
    <dbReference type="EnsemblBacteria" id="ABF88876">
        <property type="protein sequence ID" value="ABF88876"/>
        <property type="gene ID" value="MXAN_2880"/>
    </dbReference>
    <dbReference type="GeneID" id="41360249"/>
    <dbReference type="KEGG" id="mxa:MXAN_2880"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028929_1_0_7"/>
    <dbReference type="OMA" id="FKDHQFT"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="509" mass="55540" checksum="221A9675267FC184" modified="2006-07-11" version="1">MALPDLKALSLLNHVPPRLLSAAERYLKAVPGVKGLLNRETGSLLSELESGLKPYRGKMQSFDHLPPTGRSREDVLRELQALESQEEYRWREGRVSGGVYNGDAEHIAFLNRVYALHSQSNPLHADLWPSATKFEAEVVAMTASMLGADVANAGQPEEARICGAMSSGGTESIMLAMKTYRDWARETKGITRPEMVAPASAHPAFDKAAHYFGIKMVRVPVGPDYRADVAAMRKAINRNTIVLIGSAPGFPHGVIDPIEALSEIARKKRIGFHTDACLGGFVLPFAMKLGYDVPPFDFRLPGVTSMSVDTHKFGYAAKGSSVVLYRGTELRSHQYFTATDWPGGIYFSPTFSGSRPGALIASAWAALVSTGEQGYLDATRSILETAAAIKKGIRDIPELHVLGDPLFVIAFGSESVDIFQVMERMSEHGWNLNGLHKPSAVHLCVTLRHTQPGVAEQFLVDLRDAVDYVKSHPSAKGTMAPVYGMAASVPFRGLVSDLLKKYMDLLYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8H1</accession>
    <name>Q1D8H1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552902.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2841"/>
    <dbReference type="EnsemblBacteria" id="ABF86236">
        <property type="protein sequence ID" value="ABF86236"/>
        <property type="gene ID" value="MXAN_2841"/>
    </dbReference>
    <dbReference type="GeneID" id="41360212"/>
    <dbReference type="KEGG" id="mxa:MXAN_2841"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_7"/>
    <dbReference type="OMA" id="HHAEPFG"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="48"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="514" mass="56024" checksum="3FA76804E1A26D7F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P8</accession>
    <name>Q1D8P8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552825.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2758"/>
    <dbReference type="EnsemblBacteria" id="ABF92990">
        <property type="protein sequence ID" value="ABF92990"/>
        <property type="gene ID" value="MXAN_2758"/>
    </dbReference>
    <dbReference type="GeneID" id="41360135"/>
    <dbReference type="KEGG" id="mxa:MXAN_2758"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_3_7"/>
    <dbReference type="OMA" id="CPCHEVG"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="105" mass="11481" checksum="965BB0062D25E277" modified="2006-07-11" version="1">MTKIKLGPADFAEREMRGYEVGKRNVCIAKIHGRYKGLDDWCNHAGCLLSGGRIEDNMVVCPCHEVGFDMDTGRNATSPGVCDDQPTVQVAVEDGSLVIDWPDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9J1</accession>
    <name>Q1D9J1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552534.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92272">
        <property type="protein sequence ID" value="ABF92272"/>
        <property type="gene ID" value="MXAN_2462"/>
    </dbReference>
    <dbReference type="GeneID" id="41359845"/>
    <dbReference type="KEGG" id="mxa:MXAN_2462"/>
    <dbReference type="eggNOG" id="ENOG5032Y4V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082101_0_0_7"/>
    <dbReference type="OMA" id="GQAATTW"/>
    <dbReference type="OrthoDB" id="1355931at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="31132" checksum="C9B2653CED39C49F" modified="2006-07-11" version="1">MHRAPSRGFIPLSCPAVLEGRGRPHETWENTMRLKNALSRGLPLMLLGASLACSACSDGGTSGPGPSGEREKNVVKGKATDTAGKPLAGVEVVADNQVLYDSNVVGVTGTDGTYRLELGQAATTWNASARLKRDFNGRSYTFELHPSNATPFAGNEGAVRDFSWKLTGAKPEGGAYGSGVYFNLTDYVDPADPDQALQREHVELTLTPVGSLVDGSAGTPVTARGTNTPDGFGFPDLPLGRYTVTGRYAPPGQAVRPLLVRVQDQGTYAESVTADFQPVMEGLYRLDVELKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9S1</accession>
    <name>Q1D9S1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_2382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552457.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2382"/>
    <dbReference type="EnsemblBacteria" id="ABF92391">
        <property type="protein sequence ID" value="ABF92391"/>
        <property type="gene ID" value="MXAN_2382"/>
    </dbReference>
    <dbReference type="GeneID" id="41359767"/>
    <dbReference type="KEGG" id="mxa:MXAN_2382"/>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_7"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF92391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="48431" checksum="527581A23CCD8C51" modified="2006-07-11" version="1">MAAGPDGVSLGRPMSPIDTDALAGDLLEYIDASPTPYHAVRESARRLTQAGYRQLDEREPWAPEPGARVFITRGDTSIAAFHLGTQPVDRAGFRLVGSHTDSPNLRVKPNAAVTKNGYQQLGVEIYGGVLLHTWTDRDLSLAGRVMVMVEGRPQRHLVDFRRPLLRVPNLAIHLNRGVNSDGLKLNAQEHMVPVLGLERAGVAELHGLLLEELAKGGVKAQAGDILGYDLCLYDLQPSIRSGAHGEFLHAPRLDNLASCHASLSALLSSSEPREATSGVILFDHEEVGSRSAQGAASPFLRTLLERLTLAHSDGKPDAFHRAIAHSFLVSADMAHAIHPNYPSLHEPKHQPHMGAGPVIKSNVNQSYATDGESWAFFTALCREAGVTPQHFVTRTDLGCGSTIGPISAGQLGIRTVDVGNPMLSMHSIREMACATDVAQMVAVLSRLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9S9</accession>
    <name>Q1D9S9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552449.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2374"/>
    <dbReference type="EnsemblBacteria" id="ABF91040">
        <property type="protein sequence ID" value="ABF91040"/>
        <property type="gene ID" value="MXAN_2374"/>
    </dbReference>
    <dbReference type="GeneID" id="41359759"/>
    <dbReference type="KEGG" id="mxa:MXAN_2374"/>
    <dbReference type="eggNOG" id="COG4297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084522_1_0_7"/>
    <dbReference type="OMA" id="WRYTMYS"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188406" description="Cupin_2 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="3">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="22031" checksum="B0CEAB1362A8D54A" modified="2006-07-11" version="1">MTRLQRRLLRGALATTFLLGAPGMTQTTLQPSTSKVQQAASPERLLFKDDGMTPNSRLPTLVYRGVTLEGDKASALETLFSANGWPARWRYTVYDFHHYHSNAHEVLGVAAGTARLKLGGESGQEVTVQAGDVLVLPAGTGHRRLEASRDFLVVGGYPGGTGDYDLQRPEKATHDASVQRIAQVPLPGADPVTGKQGVLSSAWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9T4</accession>
    <name>Q1D9T4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3'(2'),5'-bisphosphate nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552444.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2369"/>
    <dbReference type="EnsemblBacteria" id="ABF90326">
        <property type="protein sequence ID" value="ABF90326"/>
        <property type="gene ID" value="MXAN_2369"/>
    </dbReference>
    <dbReference type="GeneID" id="41359754"/>
    <dbReference type="KEGG" id="mxa:MXAN_2369"/>
    <dbReference type="eggNOG" id="COG1218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_3_0_7"/>
    <dbReference type="OMA" id="IYNRPDP"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="29618" checksum="F2511C495968561A" modified="2006-07-11" version="1">MHPLDAELDIARRVARQAGAILLEVYATPFAVHDKAGGMGPVTEADERANAFIVEALRDAFPSDGVVAEESDNTSGASRFERCWFVDPMDGTQEFVNRNGEFAIHIGLAIAGKATLGVVYRPVGDTLYWGVVGQGGFVEHAKGRRALRVSDTAEPSALRLVVSRSHRSRLTDAVVRRLGITHEQACGSVGLKCGLLAEAACDLYLHVSDKSYRWDNCAPEAVLRAAGGILTDLGGTPYAYDGSELQNRRGLLACNAAAFEHVAPVVAGFAREAGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAF1</accession>
    <name>Q1DAF1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87770">
        <property type="protein sequence ID" value="ABF87770"/>
        <property type="gene ID" value="MXAN_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2149"/>
    <dbReference type="HOGENOM" id="CLU_3366018_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="35" mass="3854" checksum="27EE71D637C73F88" modified="2006-07-11" version="1">MHVSRLAHIAESPFGKAFKRSVGVTPGAFRQREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAH0</accession>
    <name>Q1DAH0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2129"/>
    <dbReference type="EnsemblBacteria" id="ABF87428">
        <property type="protein sequence ID" value="ABF87428"/>
        <property type="gene ID" value="MXAN_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2129"/>
    <dbReference type="HOGENOM" id="CLU_1883514_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030916">
        <property type="entry name" value="ELWxxDGT_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04534">
        <property type="entry name" value="ELWxxDGT_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14243" checksum="279139C023549156" modified="2006-07-11" version="1">MSARLSFLAPLTLLTLHGCDAAPSDSAPLRTQSAELAPATGPVTLVTDLNVTSLARQLSLSDQFTRMGGSVYFSATGTGVGQELWRTDGTPQGTTLVRDIIPGPWGHRPLPAHGVEGAAVLRRLPAVGWHHALRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ9</accession>
    <name>RECR_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">MXAN_1930</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552029.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAZ9"/>
    <dbReference type="SMR" id="Q1DAZ9"/>
    <dbReference type="STRING" id="246197.MXAN_1930"/>
    <dbReference type="EnsemblBacteria" id="ABF87659">
        <property type="protein sequence ID" value="ABF87659"/>
        <property type="gene ID" value="MXAN_1930"/>
    </dbReference>
    <dbReference type="GeneID" id="41359344"/>
    <dbReference type="KEGG" id="mxa:MXAN_1930"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_7"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000322919" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="197" mass="22047" checksum="87852B9CD7C6A74C" modified="2006-07-11" version="1">MTPDPLNRLVAQLAKLPGIGEKTAQRLAFHILRAPGEYAAELSQAIREVKEKVHLCVRCFSLTDAETCNFCRDARRDERVLCVVETFADLMALERTREFKGRYHVLHGVLSPLEGVGPDQLRIRELLERLNDSRVEELILATNPDVEGEATALYLTRLLKPMGLRVTRIAQGLPMGGDLEFADQATLAKALSARRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF7</accession>
    <name>Q1DBF7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RibD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551875.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1766"/>
    <dbReference type="EnsemblBacteria" id="ABF90252">
        <property type="protein sequence ID" value="ABF90252"/>
        <property type="gene ID" value="MXAN_1766"/>
    </dbReference>
    <dbReference type="GeneID" id="41359192"/>
    <dbReference type="KEGG" id="mxa:MXAN_1766"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_7"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20608" checksum="BBCB3AC529966D50" modified="2006-07-11" version="1">MGLLTFSINVTLDGCVDHQEGIADNETHAFFTRLMDEGGAMLWGRVTYEMMESYWPAVARGDEEAPPAMREWAVNLEAKPKYVVSSTRKDFPWTNSHHIAGDLRTGVQKLKDATPAGVLLGSGKLATELDRLDLIDEYKFLVHPRIAGHGPTLYQSGLPSTRRLELLSAKPLRSGAVAMHYRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ7</accession>
    <name>Q1DBJ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1725"/>
    <dbReference type="EnsemblBacteria" id="ABF90605">
        <property type="protein sequence ID" value="ABF90605"/>
        <property type="gene ID" value="MXAN_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1725"/>
    <dbReference type="HOGENOM" id="CLU_2539039_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="83" mass="9322" checksum="F7CF0A95A902E864" modified="2006-07-11" version="1">MALRLARASVLIRIHAHDGGLHPVSRGVARTRSEVLSEELDFDCAEREAACRFKARYRLRNGTSEAEVIDAAFLGLRRREVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX9</accession>
    <name>Q1DBX9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1592"/>
    <dbReference type="EnsemblBacteria" id="ABF91321">
        <property type="protein sequence ID" value="ABF91321"/>
        <property type="gene ID" value="MXAN_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1592"/>
    <dbReference type="eggNOG" id="ENOG503228V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767112_0_0_7"/>
    <dbReference type="OMA" id="FISHVWK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="347" mass="38091" checksum="01110537FF2D9A1D" modified="2006-07-11" version="1">MPPAGVSSAGRKHRMGSADHRLSGIALSWLMTRSERRGTRKELEDALRPFVEHQLSRAEWKLRFEALMEALLGGGTVAVRGRSGLELTPKGRTEVLRFLQLDQPPRGLTWKRLKATHLVARSLDLRPSKAVLARMKGADGVRAAALQRQHGLDTEEGLTLAQTRDRLLWRQLGVETDRPFTLGAVQAHLLGKMLDAKTMDPRKGVEQLAARAAGAPRVDAEAVRLSLMRRWAVAQDADASEDAPADRASTSPDAPPSPAAFAERVLSVARALPTGRFGENKVFISHVWKALQPEWSTREAFDAALLEANRTRLLSLTRADLVSAMDPNDVADSEVRSFGASFHFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC37</accession>
    <name>Q1DC37_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen debranching enzyme GlgX</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgX</name>
        <name evidence="4" type="ORF">MXAN_1534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551645.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1534"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86431">
        <property type="protein sequence ID" value="ABF86431"/>
        <property type="gene ID" value="MXAN_1534"/>
    </dbReference>
    <dbReference type="GeneID" id="41358979"/>
    <dbReference type="KEGG" id="mxa:MXAN_1534"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_7"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="168"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="713" mass="80295" checksum="1460B7588C483153" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC70</accession>
    <name>Q1DC70_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aqualysin I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551612.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DC70"/>
    <dbReference type="STRING" id="246197.MXAN_1501"/>
    <dbReference type="MEROPS" id="S08.051"/>
    <dbReference type="EnsemblBacteria" id="ABF87445">
        <property type="protein sequence ID" value="ABF87445"/>
        <property type="gene ID" value="MXAN_1501"/>
    </dbReference>
    <dbReference type="GeneID" id="41358947"/>
    <dbReference type="KEGG" id="mxa:MXAN_1501"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_7"/>
    <dbReference type="OMA" id="SGQYSWI"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188126" evidence="6">
        <location>
            <begin position="23"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="159"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="46304" checksum="9221E09EDA03B716" modified="2006-07-11" version="1">MNRHTLKLFVSVGMMLLMGACASRQVPCKDRTASRPTMGQKQTGKFITVRKKIPGEYIVVLKSPAQSLEQVEVQQATTSLITAYGGTAFAMYENALRGFAAKMTEAQARAMANDPAVDYVQENGVVKIAESQQGPTWGIDRMDQRKLPLDKVYTFTATGQGVHIYILDTGVRFSHREFGGRASIGYDAIGDSMRGNDCNGHGTHVAGTAAGASYGLARNAIVHSVRVLGCDGSGATSGVIEGIDWVTRNHISPAVANMSLGSDEDPALDDAVRRSIAAGVTYVVAAGNEDNDACKHSPARAPEAITVAATDNKDKRATFSNWGDCVDVFAPGNKIKSSWHYGDRESREMSGTSMATPHVTGLAALFLEVNPTAKPETVANAVFTNATENTVSNPGWCSPNLMAYSGFITALPGLPVVQLKDFLPKPAVVSSSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK1</accession>
    <name>Q1DCK1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neisseria_PilC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551482.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1365"/>
    <dbReference type="EnsemblBacteria" id="ABF92220">
        <property type="protein sequence ID" value="ABF92220"/>
        <property type="gene ID" value="MXAN_1365"/>
    </dbReference>
    <dbReference type="GeneID" id="41358811"/>
    <dbReference type="KEGG" id="mxa:MXAN_1365"/>
    <dbReference type="eggNOG" id="COG3419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248975_0_0_7"/>
    <dbReference type="OMA" id="SPARVEC"/>
    <dbReference type="OrthoDB" id="165468at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008707">
        <property type="entry name" value="PilC_beta_prop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05567">
        <property type="entry name" value="Neisseria_PilC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188379" description="Neisseria_PilC domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="Neisseria_PilC" evidence="2">
        <location>
            <begin position="776"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1494" mass="160857" checksum="A9FDF427FE5F976A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL7</accession>
    <name>Q1DCL7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551466.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1DCL7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1349"/>
    <dbReference type="EnsemblBacteria" id="ABF90736">
        <property type="protein sequence ID" value="ABF90736"/>
        <property type="gene ID" value="MXAN_1349"/>
    </dbReference>
    <dbReference type="GeneID" id="41358795"/>
    <dbReference type="KEGG" id="mxa:MXAN_1349"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_7"/>
    <dbReference type="OMA" id="GHVVECS"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="25914" checksum="30C3377D7B218CBD" modified="2006-07-11" version="1">MSDKTRSILVVEDDLSILTGLSMNLRFEGYEVLQAQDGRTGLARALDESPDLVVLDVMLPELNGFEVLKELRQRGRDTPVVVLSAKGMETDKIVGLNLGADDYVVKPFGLQELLARIKAVLRRRYPSAGAGSPPPVTFGDVSVDMAARTVARARTPVELTAQEFKLLAHFLAHPGRTFTREELLSGAWGYHYEGSARTVDNFMRQLRLKFEPDPEAPRHFLTVRGLGYRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM0</accession>
    <name>Q1DCM0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551463.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86331">
        <property type="protein sequence ID" value="ABF86331"/>
        <property type="gene ID" value="MXAN_1346"/>
    </dbReference>
    <dbReference type="GeneID" id="41358792"/>
    <dbReference type="KEGG" id="mxa:MXAN_1346"/>
    <dbReference type="HOGENOM" id="CLU_1446216_0_0_7"/>
    <dbReference type="OMA" id="IVIDAGW"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21858" checksum="FEE4D3AB5D0B72E8" modified="2006-07-11" version="1">MTDARPKVKPVQGNRDELIDALRQRLAGSFRWASVGVALGTLAVLYGASSFQRALDSGRFRWPFSAQLPIWGSLLIVIGLAAFWLAPRYTRRLVRSVESDERTSLLMTVERKRVPGDDEHFLFVATLYSPEQQRVVLRNVHFLQGDKPLQYPYKEGVTQVPVQVYGKPGQAPIVIDAGWGFLLPANLTYPWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT5</accession>
    <name>Q1DCT5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1281"/>
    <dbReference type="EnsemblBacteria" id="ABF89112">
        <property type="protein sequence ID" value="ABF89112"/>
        <property type="gene ID" value="MXAN_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1281"/>
    <dbReference type="HOGENOM" id="CLU_2700913_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="7861" checksum="C0F689C1C08E27D8" modified="2006-07-11" version="1">MSGNDHSGRRSQQRPGSHVRLAVHASRSQEPPAMFALPSPVLVVAAIVLFPVVLAGSMLLDAFETELEERPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCU0</accession>
    <name>Q1DCU0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-cysteine ligase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551393.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1276"/>
    <dbReference type="EnsemblBacteria" id="ABF88581">
        <property type="protein sequence ID" value="ABF88581"/>
        <property type="gene ID" value="MXAN_1276"/>
    </dbReference>
    <dbReference type="GeneID" id="41358722"/>
    <dbReference type="KEGG" id="mxa:MXAN_1276"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029030_0_0_7"/>
    <dbReference type="OMA" id="RYHAMAN"/>
    <dbReference type="OrthoDB" id="367541at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="496" mass="54446" checksum="CBC09881883E7202" modified="2006-07-11" version="1">MGMAIHQEEFRPEDHERFSRRLAESLEALRALLARPGFGVGAPTVGAELELYLVDRLGFPLPVNRAVLARAEDPRVTLELDAFNLEVNLRPCPLAGRSFSALRQEVESAVSAVRRAASMLGARVAVIGILPTLREADLGSGALTSEPRYRAMSTAIRQRRSAPFHVSIRGEEEALSLTWKDVTLEGANTSLQYHLRVAPGDFARMYNAAQLATAPVLAAAGNSPLFLGRKLWDETRVALFRQAVDDRGEPGEGGFQPHARVSFGHGWVREGAYELFAEAVALHPPLLPVSGDEPLRERVAAGEVPDLEELRLHQSTVWSWNRAIYDPKAGGHLRIEFRALPAGPTLVDMMANGAFLLGLTLALAERVDALLPALPFVHAYGNFIRAARQGLDAELLWPSSTAPSPRPMAATELVKRLLPDAREGLVRAGVDAEEADTLLGILEQRVVLRRTGATWQRQMLARLESQMPRRDALAAMLERYLQRSESGAPVHTWPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCU2</accession>
    <name>Q1DCU2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1274"/>
    <dbReference type="EnsemblBacteria" id="ABF88808">
        <property type="protein sequence ID" value="ABF88808"/>
        <property type="gene ID" value="MXAN_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1274"/>
    <dbReference type="HOGENOM" id="CLU_1364989_0_0_7"/>
    <dbReference type="OMA" id="DERRWIH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="22500" checksum="1D311C91338BCD4F" modified="2006-07-11" version="1">MRRAHARMPATPRALRAKRTRHDAKVHPSGSRVTPRAVRRVGGGRPCRLRVVPLARDTAMGTFFPSASPGRWAMLSIQEHATVDEASSELLDFVLEPYNWLSLPRTGMDPAAWPGQNTLYQRRVGSLRICASVDVAATLDVFLHIAFRAPGLTPVKAADHLESFLKQRLPLTPNSEWQVEVDERRWIHFSRRYAGPHLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCV6</accession>
    <name>Q1DCV6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1260"/>
    <dbReference type="EnsemblBacteria" id="ABF90116">
        <property type="protein sequence ID" value="ABF90116"/>
        <property type="gene ID" value="MXAN_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1260"/>
    <dbReference type="eggNOG" id="ENOG5031IT5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166795_0_0_7"/>
    <dbReference type="OMA" id="QRGLSYF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13947" checksum="3060EF9F0DE36A3B" modified="2006-07-11" version="1">MLQVAQVFGTSGREMDVPFFPRENASRMADIIDLTFLADVRRFYKKLIDQRGLSYFLQKEGPRLFHIEPSKVELVLRTALRTRDPQLPRPHDKAIEHCRKEVRRDLIRRVANAMLQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCZ3</accession>
    <name>Q1DCZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551148.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1027"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89766">
        <property type="protein sequence ID" value="ABF89766"/>
        <property type="gene ID" value="MXAN_1027"/>
    </dbReference>
    <dbReference type="GeneID" id="41358481"/>
    <dbReference type="KEGG" id="mxa:MXAN_1027"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OMA" id="ICHAIWP"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="182"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="378" mass="41203" checksum="C79F38DB7BF2FAF4" modified="2006-07-11" version="1">MSHPLRVLHISSGNLYGGIETLLHTMARERNLRPSLSHAFALCFEGRLARELRDAGVEVHVLGPAKTGRPWSVWRARSVLRELLRGGRYDVVICHAIWPQALFGPVVRTAGVPLAFFQHDALTGQHWLERWARVTPPDLVLTNSRFAAGTLVSVYPQVPWRVTHCPLPMPPPALGASERARLRTELGASEGDAVIFHASRMQEGKGQRLLLEALGRLRAVPGWCVWFAGGAQRPDEEAYQEGLRAQAKHLGIEGRLRLLGQRSDVPRLLRAADIHCQPNSRPEAFGLVFVEALQAGLPVVTTPMGGALEIVDASCGVFVRPEPESLALALGRLIEDPQTRARLGAAGPARAAALCDAGGFLRGMEEALRALSEQEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY2</accession>
    <name>Q1DDY2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551001.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0880"/>
    <dbReference type="EnsemblBacteria" id="ABF90132">
        <property type="protein sequence ID" value="ABF90132"/>
        <property type="gene ID" value="MXAN_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="41358339"/>
    <dbReference type="KEGG" id="mxa:MXAN_0880"/>
    <dbReference type="HOGENOM" id="CLU_645323_0_0_7"/>
    <dbReference type="OMA" id="GWTLRTW"/>
    <dbReference type="OrthoDB" id="1130856at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="43985" checksum="4EB971AD4D34132F" modified="2006-07-11" version="1">MRGLGAPRAPHSVARSVAIQEGAMRIPVAPVTALLALVLLAAPSWAQEQGGLGLDLTSDAPAEQQGMDMGLDLRPSNPNADLLPRFALVGLYATERAGAQQASSWLEALARGALSSAMVAQASDLVETRERLAEGHDAAVRCAEAACFAEPAELLDADLLTTARLSLEDAGWTLRTWTYDRDLRVVHEDFVTGRNPRDEDFANEAAAMLSKRLTALARPRAMLTVNVNVPQAVVKVGERIVGVGSVEVRQAPGAVAVEVSADEYGTQTRTLDLMPGARETVDVMLEISGPAPDGPPDDSVVGVASSRKAPQKSLFKRPALYTVLVGLAAVGAGVVMGMAAKDVEKRGGDADGDGMFDVTRKERLDAQSQANLATALLVGGGAVTAGSVAWLVLVPARSAPASTSVAPGSGGGASTSLHIMVGGSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDZ9</accession>
    <name>SELO_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
            <ecNumber evidence="1">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selO</name>
        <name type="ordered locus">MXAN_0863</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:54289"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:54293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:58121"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EC" id="2.7.7.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550984.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDZ9"/>
    <dbReference type="SMR" id="Q1DDZ9"/>
    <dbReference type="STRING" id="246197.MXAN_0863"/>
    <dbReference type="EnsemblBacteria" id="ABF91154">
        <property type="protein sequence ID" value="ABF91154"/>
        <property type="gene ID" value="MXAN_0863"/>
    </dbReference>
    <dbReference type="GeneID" id="41358322"/>
    <dbReference type="KEGG" id="mxa:MXAN_0863"/>
    <dbReference type="eggNOG" id="COG0397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010245_4_1_7"/>
    <dbReference type="OMA" id="YGPYGWL"/>
    <dbReference type="OrthoDB" id="130048at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000271835" description="Protein adenylyltransferase SelO">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <sequence length="488" mass="53829" checksum="F2108B7306E255D4" modified="2006-07-11" version="1">MATLEQLRFDNTYARLPAGFGARVHPSPFPDAKLVSVNPAALKLLDLTPEEAQRPEFVAAMGGAKPLPGMEPFAMVYAGHQFGVYVPRLGDGRALLLGEVRDAAGAKWDLHLKGGGPTPFSRGGDGRAVLRSTIREYLCGEAMHGLGIPTTRGLGILGSQAPVYREAVETGAMLVRMAPSHVRFGTFEFFHYTEQTEHVATLADHVITEHFPQLAGQEGRYARFYTEVVERTARLIAQWQAVGFAHGVMNTDNMSILGLTLDYGPFGFLDDFEPGFICNHSDDRGRYAFDQQPRIGLWNLACLGEALLTLISEDEARAALATYQPAYNAHFMDRMRAKLGLRETRDEDRELVSDLFARMAEAHVDYTRFFRALGHFASADGADTRPVRDMFPAPEGFDAWAGRYRARLAAEGSVDAERHARMTRVNPKYVLRNWVAQEAISRAEAGDFSLVDRLLGVLSDPFAEHPDAEPYAAAPPTWGRHLAVSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE35</accession>
    <name>Q1DE35_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550948.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0825"/>
    <dbReference type="EnsemblBacteria" id="ABF86675">
        <property type="protein sequence ID" value="ABF86675"/>
        <property type="gene ID" value="MXAN_0825"/>
    </dbReference>
    <dbReference type="GeneID" id="41358290"/>
    <dbReference type="KEGG" id="mxa:MXAN_0825"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119548_1_0_7"/>
    <dbReference type="OMA" id="FKATSRH"/>
    <dbReference type="OrthoDB" id="1481875at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22861" checksum="A086502419323503" modified="2006-07-11" version="1">MPLHTLNALPDEVFRVPTVSLLLFVLASAPANTAPADSKAAITAVLDDWHQAAAAADEARYFGHFTDDAVYLGTDATERWTRDEFRAWAKPYFSKGKAWNFKATSRHIFLSKDGAVAWFDEALDTPNLGPSRGSGVLVKDAGTWKIAQYNLSIPIPNDVLPEVKRRIERELARSQKTPGKSSTWRAPPAKVPSPQTPPIKERAPAQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEK4</accession>
    <name>Q1DEK4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550782.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0651"/>
    <dbReference type="EnsemblBacteria" id="ABF88470">
        <property type="protein sequence ID" value="ABF88470"/>
        <property type="gene ID" value="MXAN_0651"/>
    </dbReference>
    <dbReference type="GeneID" id="41358126"/>
    <dbReference type="KEGG" id="mxa:MXAN_0651"/>
    <dbReference type="eggNOG" id="ENOG5032SI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138456_0_0_7"/>
    <dbReference type="OMA" id="AGVLVYC"/>
    <dbReference type="OrthoDB" id="1779307at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="138" mass="15341" checksum="296269666C211384" modified="2006-07-11" version="1">MPAPSSFDYAIIRVVPRVEREEFINAGVVLFCATQRFLGVRVEPDEARLKALWPDVDVDMIRGHLESFRRVCEGGKGSGPIGQLSQKERWHWVVAPRSTIIQTGPVHSGLCTEPQAALEHLLDTVVRMKRATPSPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEM4</accession>
    <name>Q1DEM4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0631"/>
    <dbReference type="EnsemblBacteria" id="ABF91976">
        <property type="protein sequence ID" value="ABF91976"/>
        <property type="gene ID" value="MXAN_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0631"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085475_0_0_7"/>
    <dbReference type="OMA" id="CASLQHF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="27696" checksum="D6A4B90C50588937" modified="2006-07-11" version="1">MRRLVQVLDVELSPAKPHASLVDARRLEAADPMAFAALVKYMQPREKDFSTSVLKQALVRPEGVVGAVVGGFYTLLSGAYPSRAFTAPDTALQWLGQPEAEAAALLAELNGLVAEATGQSPLLRELHQVMRGRLPEVNLSDVAREMGMSERTLQRRLKEASTSFQAELNAVQVRMAQSLLRESNMKLTAVAVEVGCASLQHFSSLFRKLVGESPSAWRDRQKQPQGDGTPPPAEALMEEVAGAPGKGPVAATSEVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEM8</accession>
    <name>Q1DEM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550758.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0627"/>
    <dbReference type="EnsemblBacteria" id="ABF93097">
        <property type="protein sequence ID" value="ABF93097"/>
        <property type="gene ID" value="MXAN_0627"/>
    </dbReference>
    <dbReference type="GeneID" id="41358105"/>
    <dbReference type="KEGG" id="mxa:MXAN_0627"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092792_0_0_7"/>
    <dbReference type="OMA" id="AVWTHAR"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="25156" checksum="B8E091893B19D863" modified="2006-07-11" version="1">MASTSAAKANRALPQRARKDEDKEARRQLILDEALALYQATSYAEVKMADVAGRAMLAKGTVFLYFPTKEALFLALLEDLLFAWFARLDGLLVEDSSAWTGPRLARTVAESLEGEEALTRLLARLQTVLEQNVTAEQLRPFKERLLAALLRAGTLVEQRLPFLHAGEGPRFFIHLHALVTGLRQMADVAPVAREVLEALPHLAPLRVDFTAELTTALTTLLRGLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP9</accession>
    <name>Q1DEP9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, small conductance mechanosensitive ion channel (MscS) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0606"/>
    <dbReference type="EnsemblBacteria" id="ABF92446">
        <property type="protein sequence ID" value="ABF92446"/>
        <property type="gene ID" value="MXAN_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0606"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036700_0_0_7"/>
    <dbReference type="OMA" id="VINYSRG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="565" mass="61795" checksum="0B400C04418CD500" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ1</accession>
    <name>Q1DEQ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550735.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0604"/>
    <dbReference type="EnsemblBacteria" id="ABF92617">
        <property type="protein sequence ID" value="ABF92617"/>
        <property type="gene ID" value="MXAN_0604"/>
    </dbReference>
    <dbReference type="GeneID" id="41358082"/>
    <dbReference type="KEGG" id="mxa:MXAN_0604"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825908_0_0_7"/>
    <dbReference type="OMA" id="EKQWRRE"/>
    <dbReference type="OrthoDB" id="1439250at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="40243" checksum="CC0EEE6F9B552EA7" modified="2006-07-11" version="1">MHMQQATNGALPLPEGACRRYRHLVPRGRSQPPVSPPSRIQHERLLRLEDALSEGRAREDAAVEAWVRRTGQMPPRKIRRKWEKQWRREAKRAARRAEREVLSNRSRNPARGAAYVTASITCVLIALAQPRRLWWLVFVALGFFLASLKHLERPRRDEGRARDAGVPEREPVGVSEGEADARVAKVDALCARLMEALGEGPAVLRELVHAPERTVEALRQGCHALVRRERELRALAPPAETQRLDAERDALAARVASEEDAVVRERLAGALAALESQRRQRAELAIAAARLEAEHMRLYYTLESLYAQVLRVRSADTVGEDIAGLGLRQSVEQLGAEVEAVAQALEEVHAAPGGGGRTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DET2</accession>
    <name>Q1DET2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550704.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0572"/>
    <dbReference type="EnsemblBacteria" id="ABF92333">
        <property type="protein sequence ID" value="ABF92333"/>
        <property type="gene ID" value="MXAN_0572"/>
    </dbReference>
    <dbReference type="GeneID" id="41358055"/>
    <dbReference type="KEGG" id="mxa:MXAN_0572"/>
    <dbReference type="HOGENOM" id="CLU_969185_0_0_7"/>
    <dbReference type="OMA" id="TTVYASM"/>
    <dbReference type="OrthoDB" id="1489236at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="29182" checksum="210BEEA296EE5535" modified="2006-07-11" version="1">MKKVLIGLGIGCGVFILAGIGLMLAGGIWAKNKFGGSIEAMQSIQAQEQELTQLNASNPFKAPPEGQVLPLDEPRLLAYLTVRESALPAFKAFEAKSKEFEAQHAGDGDEKPGFNAAVDAASLFMGLMADVRKAYIAGLKAQGMSPAEFQSITTTVYASMVADSLEQIGAAAEQGRKMMVTQLAEVDKRLADDSLADEERAQLEEARAQLQDTLDAIEEPGANEEQPLSEASKKAAAANVELLKKHKERVELMANVAFDGFVLGGAGADGQAAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFE4</accession>
    <name>Q1DFE4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pilus biogenesis operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550493.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0355"/>
    <dbReference type="EnsemblBacteria" id="ABF91767">
        <property type="protein sequence ID" value="ABF91767"/>
        <property type="gene ID" value="MXAN_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="41357853"/>
    <dbReference type="KEGG" id="mxa:MXAN_0355"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506067_0_0_7"/>
    <dbReference type="OMA" id="YWRATLV"/>
    <dbReference type="OrthoDB" id="1529839at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="58955" checksum="04514EC2322ACE79" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM8</accession>
    <name>Q1DFM8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">DNA gyrase subunit B</fullName>
            <ecNumber evidence="4 12">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">gyrB</name>
        <name evidence="15" type="ORF">MXAN_0264</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550409.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0264"/>
    <dbReference type="EnsemblBacteria" id="ABF87299">
        <property type="protein sequence ID" value="ABF87299"/>
        <property type="gene ID" value="MXAN_0264"/>
    </dbReference>
    <dbReference type="GeneID" id="41357764"/>
    <dbReference type="KEGG" id="mxa:MXAN_0264"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_0_1_7"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041423">
        <property type="entry name" value="GyrB_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18053">
        <property type="entry name" value="GyrB_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="430"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF87299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="815" mass="90411" checksum="DE7A41A6A6F25ACA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS6</accession>
    <name>Q1DFS6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 3-oxoacyl-(Acyl-carrier-protein) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0215"/>
    <dbReference type="EnsemblBacteria" id="ABF92307">
        <property type="protein sequence ID" value="ABF92307"/>
        <property type="gene ID" value="MXAN_0215"/>
    </dbReference>
    <dbReference type="GeneID" id="41357717"/>
    <dbReference type="KEGG" id="mxa:MXAN_0215"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_7"/>
    <dbReference type="OMA" id="CAFIFAD"/>
    <dbReference type="OrthoDB" id="872193at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
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        <property type="entry name" value="ACP_syn_III_C"/>
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        <property type="entry name" value="Thiolase-like"/>
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        <property type="entry name" value="ACP_syn_III"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53901"/>
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    </dbReference>
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    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="240"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="35783" checksum="396B37C0DBB6F4B4" modified="2006-07-11" version="1">MRYAQILSTGRYVPEKVLTNADVEKILGEKVDEWLQQNVGIRERHMMADDQATSDLCVGAARQALERAGTKPEELDLIIIATDTPDYLSPATASVVQAKLGAVNAGTYDLNCACAGWVTALDVGSKTIAADDSYQRILVVGAYGMSRYINWKDKKTATLFADGAGAVVLGAGDTPGFMGAKLLANGEYHDALGVYTGGTNRPATAESLELTGGKPAVQFVRKFPATFNTERWPMLLDQLLKRQNLKLDDVKQFVFTQLNLRTIEATMKILGQPMEKAHYTMDKWGYTGSACIPMTLDDAVVQGKVQRGDLVALCASGGGLAMASALYRWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG25</accession>
    <name>Q1DG25_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550262.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0115"/>
    <dbReference type="EnsemblBacteria" id="ABF92726">
        <property type="protein sequence ID" value="ABF92726"/>
        <property type="gene ID" value="MXAN_0115"/>
    </dbReference>
    <dbReference type="GeneID" id="41357620"/>
    <dbReference type="KEGG" id="mxa:MXAN_0115"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079079_0_0_7"/>
    <dbReference type="OMA" id="KMLAHEG"/>
    <dbReference type="OrthoDB" id="1190895at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="28048" checksum="A2951F77509965F8" modified="2006-07-11" version="1">MWAPPIPQGRPPMRVNLFQSIARLSETRTQQSVPPAASGPAQTQAPQQPSVPDVVARYLTDSFEAAGASEVIKQTKDSNCGAAVATLLSRTAGKDSASAAQKMDTLESRFTDGGGTTPEELAKMLAHEGLEVKKGTSNFDMPSVNEALARGQQVVVQLDTNRLATGVDSKIAGDSHWVVVDGMDDKGNYQVKDTNTGTKYSVSGQQIADSVGSAWELHQGGGMLVVGDPQSAMDEGTLVEKSSLHTSVLGNTDGGGSRARGSFGRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG33</accession>
    <name>Q1DG33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550254.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0107"/>
    <dbReference type="EnsemblBacteria" id="ABF91382">
        <property type="protein sequence ID" value="ABF91382"/>
        <property type="gene ID" value="MXAN_0107"/>
    </dbReference>
    <dbReference type="GeneID" id="41357612"/>
    <dbReference type="KEGG" id="mxa:MXAN_0107"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_7"/>
    <dbReference type="OMA" id="GIMNITF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="25"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="314"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="408" mass="43705" checksum="1CD60D9A522173DB" modified="2006-07-11" version="1">MSIRVDVWEGARIALFSLRSNRLRTVLTTVGIGVGVCTLLAIVGIIQGINRSFEDQLSSIGANTLQISKFPWTLNGDWWSYRNRKDLSADLVPPILNASEHVLAAAPLFFERVEGRFLDRKIGSVLLVGTTPDYATVGSFALERGRFLTHADVDNRAQVAVIGAELVRSLFPGVNPVGQRILFEGKPFRVVGTLEAKGTILGENQDLVVVVPSRTFLAHFGKKRSPNIAVALTSPEHAPAVVDKLTAVLRRERNTPPGLPDDFAINRPDQLASMYAQLTGALYGAAMGVGLITLLVGGIGIMNIMLVSVRERTREIGVRRALGARKRTIILQFLMEASCVSALGGTLGTVVGLGLARIVSLITPLAAAVEPLTVVAGVGFAAMVGLLFGIWPAARAANLDPVEALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG40</accession>
    <name>Q1DG40_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase, M28D (Aminopeptidase ES-62) subfamily</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550247.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0100"/>
    <dbReference type="EnsemblBacteria" id="ABF91586">
        <property type="protein sequence ID" value="ABF91586"/>
        <property type="gene ID" value="MXAN_0100"/>
    </dbReference>
    <dbReference type="GeneID" id="41357606"/>
    <dbReference type="KEGG" id="mxa:MXAN_0100"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033697_1_1_7"/>
    <dbReference type="OMA" id="LFMNEEN"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188529" evidence="8">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="9">
        <location>
            <begin position="275"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="52006" checksum="E610DD85263D5567" modified="2006-07-11" version="1">MPVATFILPASLALQLLSAAAPAAKSAPKAVPAKPTVTAKRAAPVYAQATAEKLIGPALTDGHAYARLAELTDGIGPRLSGSPGAEAAVQWALRSFKADGVKAWLEPVKVPHWVRGEASGEVLASERTRGHPLALLALGGSPPTAPEGLTAEVVEVTSLEQLESLGAAVKGKFVFFNHTMTVAADYGRFAGLRSRGPAAAAKHGAVGALVRSLATASLRTPHTGATNFPSEGPRIPAASVATEDADLLHRLLAGGPVRVKLMLGSSELPDADSSNVVAEIRGREKPQEIVLIGAHLDSWDVGTGAHDDGAGVVMVMEAARLIAKLPQAPRRTVRVVLFMNEENGLRGGRAYAEAHAAELPRHVGALEMDAGGGRPVSVSVRAGEGGQDLLRPWLPPLTALGVTQFSAREAGGADISPLMPARVPFFGVEVDSSRYFDVHHTEADTLDKVDPQDLARSTAAVAWMTYALAEMPGTLTRPEAPAPRGPAPVTVPAQQSKTSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG69</accession>
    <name>Q1DG69_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4142 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550218.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0071"/>
    <dbReference type="EnsemblBacteria" id="ABF86180">
        <property type="protein sequence ID" value="ABF86180"/>
        <property type="gene ID" value="MXAN_0071"/>
    </dbReference>
    <dbReference type="GeneID" id="41357578"/>
    <dbReference type="KEGG" id="mxa:MXAN_0071"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1146243_0_0_7"/>
    <dbReference type="OMA" id="HRKADEQ"/>
    <dbReference type="OrthoDB" id="1506515at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188694" description="DUF4142 domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27239" checksum="0511D9F55E70EFA8" modified="2006-07-11" version="1">MMSRSGHGRQAMKRWMGGVVAGALALGGGALAQQNGTDDTESMVRMGRPEAIDQGQAPEPFEEGTGGAGSQGTPPDARGVALLRQGLLPIPTDEKAFLDELHQANQQEVKLGRLAQRQGSSQGVKDYGARLVKDHGQADQRLMAYARKQNLTLAEPQADTDFARTMERAEEASMAKLQSLQGPAFDRAFLAAMVGDHDADIAKVMAGQQQFSGNAGLQALLGDTLPTLREHRQQAYRLLGQETPRQARRAPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG91</accession>
    <name>Q1DG91_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2018-06" db="PDB data bank">
            <title>Solution structure of MXAN_0049.</title>
            <authorList>
                <person name="Zhang Z."/>
                <person name="Chen C."/>
                <person name="Gong Y."/>
                <person name="Zhou X."/>
                <person name="Cui Q."/>
                <person name="Feng Y."/>
                <person name="Li Y."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR OF 2-194</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550198.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="6A4C">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=2-194"/>
    </dbReference>
    <dbReference type="PDBsum" id="6A4C"/>
    <dbReference type="SMR" id="Q1DG91"/>
    <dbReference type="STRING" id="246197.MXAN_0049"/>
    <dbReference type="EnsemblBacteria" id="ABF86786">
        <property type="protein sequence ID" value="ABF86786"/>
        <property type="gene ID" value="MXAN_0049"/>
    </dbReference>
    <dbReference type="GeneID" id="41357558"/>
    <dbReference type="KEGG" id="mxa:MXAN_0049"/>
    <dbReference type="eggNOG" id="ENOG5032AYW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120443_0_0_7"/>
    <dbReference type="OMA" id="FRCTKER"/>
    <dbReference type="OrthoDB" id="1931103at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="6A4C"/>
        </source>
    </evidence>
    <sequence length="194" mass="21857" checksum="99AF0720B011D4FC" modified="2006-07-11" version="1">MKYFVFKVMAEEAGYIEKLPNGSPTDWKFHEGISLAKDFPVGGEVSFSKNYPDNRNLYDFQPNIMSNLLVSGRARKLIESLGVTNAEWLPVAIKDHQGKVVGPDYAFLNLLGAEDAIDMERSEYEMDSLEKDQIGNIDALALDTSAIRPDAKMFRCTKERRLILIREDVHAAFEQAGLTGFKVYEAEGWDGLEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q59589</accession>
    <accession>Q1D0A3</accession>
    <name>PILA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Type IV major pilin protein PilA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pilA</name>
        <name type="ordered locus">MXAN_5783</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Microbiol." volume="18" first="547" last="558">
            <title>Genetic and functional evidence that type IV pili are required for social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="8748037"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1995.mmi_18030547.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF LYS-49 AND GLY-193</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1997" name="J. Bacteriol." volume="179" first="7748" last="7758">
            <title>Regulation of expression of the pilA gene in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9401034"/>
            <dbReference type="DOI" id="10.1128/jb.179.24.7748-7758.1997"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="2105" last="2112">
            <title>Regulating pilin expression reveals a threshold for S motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Jelsbak L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="15743959"/>
            <dbReference type="DOI" id="10.1128/JB.187.6.2105-2112.2005"/>
        </citation>
        <scope>EXPRESSION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="76" first="1500" last="1513">
            <title>PilA localization affects extracellular polysaccharide production and fruiting body formation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Yang Z."/>
                <person name="Lux R."/>
                <person name="Hu W."/>
                <person name="Hu C."/>
                <person name="Shi W."/>
            </authorList>
            <dbReference type="PubMed" id="20444090"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2010.07180.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-32 AND ASP-104</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Microbiology" volume="157" first="1920" last="1928">
            <title>Alanine 32 in PilA is important for PilA stability and type IV pili function in Myxococcus xanthus.</title>
            <authorList>
                <person name="Yang Z."/>
                <person name="Hu W."/>
                <person name="Chen K."/>
                <person name="Wang J."/>
                <person name="Lux R."/>
                <person name="Zhou Z.H."/>
                <person name="Shi W."/>
            </authorList>
            <dbReference type="PubMed" id="21493683"/>
            <dbReference type="DOI" id="10.1099/mic.0.049684-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF ALA-32</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2016" name="Mol. Microbiol." volume="102" first="37" last="53">
            <title>Type IV-pili dependent motility is co-regulated by PilSR and PilS2R2 two-component systems via distinct pathways in Myxococcus xanthus.</title>
            <authorList>
                <person name="Bretl D.J."/>
                <person name="Mueller S."/>
                <person name="Ladd K.M."/>
                <person name="Atkinson S.N."/>
                <person name="Kirby J.R."/>
            </authorList>
            <dbReference type="PubMed" id="27393239"/>
            <dbReference type="DOI" id="10.1111/mmi.13445"/>
        </citation>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2016" name="J. Bacteriol." volume="198" first="77" last="90">
            <title>Cyclic Di-GMP Regulates Type IV Pilus-Dependent Motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Skotnicka D."/>
                <person name="Petters T."/>
                <person name="Heering J."/>
                <person name="Hoppert M."/>
                <person name="Kaever V."/>
                <person name="Soegaard-Andersen L."/>
            </authorList>
            <dbReference type="PubMed" id="26124238"/>
            <dbReference type="DOI" id="10.1128/jb.00281-15"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 8 9">Major component of the type IV pili that are required for social gliding motility through cycles of extension and retraction. Extended pili are composed of thousands of copies of PilA and retract upon binding to extracellular polysaccharides and thereby pull the cell forward.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The two-component PilS2/PilR2 is required for proper assembly of T4P and regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Fimbrium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 6 9">By the two-component system PilR/PilS component PilR (PubMed:9401034). In the contrary, PilS is a negative regulator of pilA expression. In addition, an increased level of c-di-GMP correlates with reduced transcription of the pilA gene (PubMed:26124238). Expression of pilA seems to be negatively regulated by the accumulation of pilin at a cell end (PubMed:15743959, PubMed:9401034).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5">Deletion mutants show loss of observable pili.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Pilin assembly limits pilus production and S motility. This limitation could be linked to the high frequency of reversal of gliding direction observed in M.xanthus. Reversal implies loss of pili at the leading pole of the cell and commissioning of new pili assembly at the other pole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the N-Me-Phe pilin family.</text>
    </comment>
    <dbReference type="EMBL" id="L39904">
        <property type="protein sequence ID" value="AAB40882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S70530">
        <property type="entry name" value="S70530"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555734.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59589"/>
    <dbReference type="SMR" id="Q59589"/>
    <dbReference type="STRING" id="246197.MXAN_5783"/>
    <dbReference type="EnsemblBacteria" id="ABF90139">
        <property type="protein sequence ID" value="ABF90139"/>
        <property type="gene ID" value="MXAN_5783"/>
    </dbReference>
    <dbReference type="GeneID" id="41363026"/>
    <dbReference type="KEGG" id="mxa:MXAN_5783"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098626_0_0_7"/>
    <dbReference type="OMA" id="WVIAGFE"/>
    <dbReference type="OrthoDB" id="1942466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028188">
        <property type="entry name" value="Pilin_PilA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14245">
        <property type="entry name" value="Pilin_PilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0281">Fimbrium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="propeptide" id="PRO_0000246780" description="Leader sequence" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000246781" description="Type IV major pilin protein PilA">
        <location>
            <begin position="13"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-methylphenylalanine" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Deficient in S motility despite its ability to produce surface pili." evidence="5">
        <original>A</original>
        <variation>L</variation>
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Complete loss of detectable cell-surface PilA; when associated with N-104." evidence="4">
        <original>A</original>
        <variation>V</variation>
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Pilus-minus S phenotype." evidence="8">
        <original>K</original>
        <variation>E</variation>
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Complete loss of detectable cell-surface PilA; when associated with V-32." evidence="4">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Pilus-minus S phenotype." evidence="8">
        <original>G</original>
        <variation>D</variation>
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15743959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20444090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="21493683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="26124238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="27393239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="8748037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="9401034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <sequence length="220" mass="23388" checksum="20B7B699C74DE3DE" modified="1996-11-01" version="1" precursor="true">MRVSRFNPRNRGFTLIELMIVVAIIGILAAIAIPNFIKFQARSKQSEAKTNLKALYTAQKSFFSEKDRYSDFANEIGFAPERGNRYGYRVSAAAGDCEVRNAADLPVPAAGVPCISNDSFRFGANSAIDDPTPVVARFVPQGAAGWNTTLGVQPTIADCPNCNFFAGARGNADNEATFDDWVIAGFEGSGQVGPCSEAGNVASGTPYNTRNDVACDGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ4</accession>
    <name>Q1CVJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ParB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="2">
        <citation type="journal article" date="2021" name="Mol. Cell" volume="81" first="3992" last="4007.e10">
            <title>The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes.</title>
            <authorList>
                <person name="Osorio-Valeriano M."/>
                <person name="Altegoer F."/>
                <person name="Das C.K."/>
                <person name="Steinchen W."/>
                <person name="Panis G."/>
                <person name="Connolley L."/>
                <person name="Giacomelli G."/>
                <person name="Feddersen H."/>
                <person name="Corrales-Guerrero L."/>
                <person name="Giammarinaro P.I."/>
                <person name="Hanssmann J."/>
                <person name="Bramkamp M."/>
                <person name="Viollier P.H."/>
                <person name="Murray S."/>
                <person name="Schafer L.V."/>
                <person name="Bange G."/>
                <person name="Thanbichler M."/>
            </authorList>
            <dbReference type="PubMed" id="34562373"/>
            <dbReference type="DOI" id="10.1016/j.molcel.2021.09.004"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 37-231</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557382.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="7BNK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=35-246"/>
    </dbReference>
    <dbReference type="PDB" id="7BNR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=37-231"/>
    </dbReference>
    <dbReference type="PDB" id="7O0N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="A/B=35-246"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CVJ4"/>
    <dbReference type="STRING" id="246197.MXAN_7476"/>
    <dbReference type="EnsemblBacteria" id="ABF91197">
        <property type="protein sequence ID" value="ABF91197"/>
        <property type="gene ID" value="MXAN_7476"/>
    </dbReference>
    <dbReference type="GeneID" id="41364621"/>
    <dbReference type="KEGG" id="mxa:MXAN_7476"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_7"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9 10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="5">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7BNK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="7BNR"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="7O0N"/>
        </source>
    </evidence>
    <sequence length="296" mass="32656" checksum="72303BC4D1A1087C" modified="2006-07-11" version="1">MVKADMQKRALGRGLSALIPQAGATGAGKGEQAPKAGVLKLPIESIHRDKDQPRTYFDEEKLKELSESIKAQGVLQPILVRKDGDGYRIIAGERRWRASQAAGLKEVPAIVRDVTEVQAFELALVENLQRADLNPIEEAEGYKRLVDEFKLTQEQVSVRVGKERSTVANALRLLALPTDVKGMVADGSLSMGHARALLGVPRLPELQNLAKQVADKKLSVRDTERLVQQSRSSGKKDAGKAAPKQSPQVKALVEELQRRLGTKVRLTERSPGKGTIEVDFFSYDDLDRLLKLLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWC6</accession>
    <name>Q1CWC6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557103.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7184"/>
    <dbReference type="EnsemblBacteria" id="ABF90554">
        <property type="protein sequence ID" value="ABF90554"/>
        <property type="gene ID" value="MXAN_7184"/>
    </dbReference>
    <dbReference type="GeneID" id="41364357"/>
    <dbReference type="KEGG" id="mxa:MXAN_7184"/>
    <dbReference type="HOGENOM" id="CLU_1260321_0_0_7"/>
    <dbReference type="OMA" id="IKFKTEG"/>
    <dbReference type="OrthoDB" id="1623444at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187713" evidence="1">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="24619" checksum="84EE4592F8AFC85A" modified="2006-07-11" version="1">MMMGMGRFLLCCSLVALTGAAGCSKPGDAEVPRAVRAQEAAGAPVAAADVKGLEGKLKFKDDADRERFSLKPKDDGAKLVDGEERELARYKWKGASLKVSGPDDVALGYVVGSAGGALTVRDGEQRQVLFTLARQGPGWRLNDMKGTLLYSVWPEDDGARIQDGAGADVARVKVREGKVSLRDAQGRTLLATKSLLAAEAAACLAFEALELPLRMALLFHLQAPPSQELAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWE1</accession>
    <name>Q1CWE1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88886">
        <property type="protein sequence ID" value="ABF88886"/>
        <property type="gene ID" value="MXAN_7169"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7169"/>
    <dbReference type="eggNOG" id="COG2881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930092_0_0_7"/>
    <dbReference type="OMA" id="CHDRVPA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27191" checksum="B5C4D02D2D4B971B" modified="2006-07-11" version="1">MCAVHPELLSLHACGRCGSFACAQCLRKGPWDEPLCAACHDRVPADALPWDRRDELGTLRAYWQTCVAVMLRPSATFERARPEGSVGSSLGFVALSNLAASFTTALFYLALLFAIPREMMDGDNVSQSWFRLAGVGVFGVMMVLAPVIGMLVALINSALDHVVFRMDGTGQPFVVTLRANALSLSPYMMGLIPFCGMYGAPFWALGLRIYAYRSLHRTGWSTAAVAALAVPLLSCGLFFAAYAVIAVVGASIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH7</accession>
    <name>Q1CWH7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4150 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7133"/>
    <dbReference type="EnsemblBacteria" id="ABF92747">
        <property type="protein sequence ID" value="ABF92747"/>
        <property type="gene ID" value="MXAN_7133"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7133"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130931_0_0_7"/>
    <dbReference type="OMA" id="NTGVNKM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025425">
        <property type="entry name" value="Tox_PAAR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13665">
        <property type="entry name" value="DUF4150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4150" evidence="1">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="17269" checksum="39DF4F85EA54AB01" modified="2006-07-11" version="1">MAPPGYSVPLEVAGMAVNTGVNKMSVVTKDSGGVTVAFPDVCKTPSPAGPVPIPYPNVAQSSDTDKGTKKVSVAGNPVCVKDSNFKTSTGDEAGTAGGGVASSKTKGKAEFVNFSFDVKFEGKNVARAFDLMLHNDKNTPPFPVMQGPVIAMGKSDEAPKCAVCDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ4</accession>
    <name>Q1CWJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91765">
        <property type="protein sequence ID" value="ABF91765"/>
        <property type="gene ID" value="MXAN_7116"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7116"/>
    <dbReference type="HOGENOM" id="CLU_1883519_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14336" checksum="4905835BB02CCD23" modified="2006-07-11" version="1">MTESTLAAAFCRESLGFGATVLRGRVRNTMSLCVRKSAVASRKHAACGLAASCLSLELGWRLPERSHAMKKNGIAMLMALGVGLAAGFGMAFMPSTAEANAPEFTQSVCERNSDCDHFCGEGFGHCIRGMYCACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWW1</accession>
    <name>Q1CWW1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556918.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88541">
        <property type="protein sequence ID" value="ABF88541"/>
        <property type="gene ID" value="MXAN_6999"/>
    </dbReference>
    <dbReference type="GeneID" id="41364175"/>
    <dbReference type="KEGG" id="mxa:MXAN_6999"/>
    <dbReference type="HOGENOM" id="CLU_112879_0_0_7"/>
    <dbReference type="OMA" id="LAYDEPR"/>
    <dbReference type="OrthoDB" id="1255131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="26712" checksum="086B5B2B27B0F029" modified="2006-07-11" version="1">MGASIHPGAQHVWLRPDGAHFFWSPPAMELRLTSRLVREPAPPQPLGPDALRELRQRCALATPEDTARGMFFRGVLETVRRVGGSAMEQLCRQPLPEKRYIDFFSYPITQFLPLAFQAAGLLSEHCGGLAAAHRFMGQKAAHDFLESVAGRTLLMLAYDEPRLLLGQLPTGFLAAVSYGERRMVWTGPRSGRFVMKRDFMPTAYHEGVLHAALEAVGARDIGVQGRELGLLDTEYALSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX00</accession>
    <name>Q1CX00_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556879.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6958"/>
    <dbReference type="EnsemblBacteria" id="ABF92686">
        <property type="protein sequence ID" value="ABF92686"/>
        <property type="gene ID" value="MXAN_6958"/>
    </dbReference>
    <dbReference type="GeneID" id="41364136"/>
    <dbReference type="KEGG" id="mxa:MXAN_6958"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072360_0_0_7"/>
    <dbReference type="OMA" id="HVANHHR"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="324" mass="36794" checksum="9CE2EAB519DD447D" modified="2006-07-11" version="1">MAGMLRYAADRRTMLWCLAMPVVALSMYVAPGWIPYLCPLACYLALSAGVIAHNHNHCPTFRNRKLNEAMGMWLSLFYGYPTFVWIPTHNLNHHKFVNKAGDATITWRYSKKHNFLVAFLFPFVSTYWQQEPTKAFIDKARERNRPLYRQILTQYAVWGGTHAALLGLAMAMHGVAGGARIWAFAFLVPALFSLWTIMFFNYIQHVHTDPWSEHDHSRSFTGRLINFFLFNNGLHAVHHETPGLHWSLLPQAHAKIEAAMDPALKPVSFFAWCFRSYVVAPFLPRFGTAQVGRAPYEPPAGVALDVRFGDDLQAVDSGVNVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX11</accession>
    <name>Q1CX11_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis protein, CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556868.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6947"/>
    <dbReference type="EnsemblBacteria" id="ABF88743">
        <property type="protein sequence ID" value="ABF88743"/>
        <property type="gene ID" value="MXAN_6947"/>
    </dbReference>
    <dbReference type="GeneID" id="41364125"/>
    <dbReference type="KEGG" id="mxa:MXAN_6947"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_4_7"/>
    <dbReference type="OMA" id="VRMVEIT"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="17342" checksum="65E5A4D6B6D7AE73" modified="2006-07-11" version="1">MTPAPTEVLLFTLNGQRYGLPAPDVRELVRAARLTPLPRAPAVVEGLLDLRGELLPVLDLRLRFRHPPRPLSPMDHFIVASAGDRCVVLRVDRAEGLRVLTPDEWDATPRQLPGVGYVAGAVKLKDGLVLVHDLRTFLSEAEALELDAALAAPQEPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX52</accession>
    <name>Q1CX52_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556827.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6907"/>
    <dbReference type="EnsemblBacteria" id="ABF88317">
        <property type="protein sequence ID" value="ABF88317"/>
        <property type="gene ID" value="MXAN_6907"/>
    </dbReference>
    <dbReference type="GeneID" id="41364089"/>
    <dbReference type="KEGG" id="mxa:MXAN_6907"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033631_1_0_7"/>
    <dbReference type="OMA" id="HSSQHYN"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="34097" checksum="B208F5F84B5AFC90" modified="2006-07-11" version="1">MDAAHIPDLITPAIPVFTLTVIAEALWVKKQRDEGRPMVGHTWKDTIASISMGLGNVAINVLWKGVAFAGYLALYHLTPLRMGTGVLAWVLIFFADDLCYYAFHRVHHESRIFWASHVVHHSSQHYNLSTALRQTWTPPTSFVFWAPLALLGFHPVMIVVQQSVSLLYQYWIHTEAIGRLPRPLEWVLNTPSHHRVHHASNPRYLDKNYAGILIIWDRLFGTFEPEGEKPVYGLTKNLETFNPVRIAFHEFAAITRDAAKPGSLKQRLSYVFRNPAWKPDAPEAPQPPGVQPPPEAARPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA8</accession>
    <name>Q1CXA8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trx</name>
        <name evidence="5" type="ORF">MXAN_6848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556773.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6848"/>
    <dbReference type="EnsemblBacteria" id="ABF91679">
        <property type="protein sequence ID" value="ABF91679"/>
        <property type="gene ID" value="MXAN_6848"/>
    </dbReference>
    <dbReference type="GeneID" id="41364037"/>
    <dbReference type="KEGG" id="mxa:MXAN_6848"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_7"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13857" checksum="A1F6A26192C1AA59" modified="2006-07-11" version="1">MAAVEITKDNFKETVSKEGIVILDWWASWCGPCRAFAPIFEQTSNNHPDIVFGKIDTDAQQELSGAFEIRSIPTLMVFRDGILLFEQPGALPAAALEDLLKQVKALDMEQVRKEVAAKRGEPPQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXF1</accession>
    <name>RS4B_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4 B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD2</name>
        <name type="ordered locus">MXAN_6805</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556730.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CXF1"/>
    <dbReference type="SMR" id="Q1CXF1"/>
    <dbReference type="STRING" id="246197.MXAN_6805"/>
    <dbReference type="EnsemblBacteria" id="ABF88254">
        <property type="protein sequence ID" value="ABF88254"/>
        <property type="gene ID" value="MXAN_6805"/>
    </dbReference>
    <dbReference type="GeneID" id="41363994"/>
    <dbReference type="KEGG" id="mxa:MXAN_6805"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_1_7"/>
    <dbReference type="OMA" id="PVICDEQ"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000293322" description="30S ribosomal protein S4 B">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="210" mass="23839" checksum="1EA066F51258E6D3" modified="2006-07-11" version="1">MARDLGPRGKMCRRLGIPLSRITAKDPDKDPVLRRPYPPGQHGATARTSVSDFARRLREKQKLKLYYGLMEKQCRAVFQEASRAPGNTGTVLLQLLESRLDSLVLRAGLATSIRQARQFVRHGYLHVDGKRADIPSFRVKPGSEVRFHAAHQKLAVVQESFSRMKSRSVPAYVQVLGEGEGLRYVRLPEREEIPVDVNEPFIVEYYAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXG4</accession>
    <name>Q1CXG4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556717.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6792"/>
    <dbReference type="EnsemblBacteria" id="ABF89708">
        <property type="protein sequence ID" value="ABF89708"/>
        <property type="gene ID" value="MXAN_6792"/>
    </dbReference>
    <dbReference type="GeneID" id="41363982"/>
    <dbReference type="KEGG" id="mxa:MXAN_6792"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_16_0_7"/>
    <dbReference type="OMA" id="FFYERCL"/>
    <dbReference type="OrthoDB" id="1661500at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="33793" checksum="E6D4D35AD514459E" modified="2006-07-11" version="1">MRDRLGGVFAFVQAVEAGSFALAAERMGLSRSAVGKSIARLEERLETRLFQRTTRRQGLTEDGQAFYERCVRALAELEAAETALDSGRRAPTGRLRVSAPVMFGRHCAAPLLRELVLQHPGLELEIAFSDRMVDLVEEGYDLALRVAPLADHAGLTARRLGVQTMSVCAAPGYLKRHGRPKTLEDLGEHDAVVYGRNGVNKPWRFPDGQGGEQRIAVQARLRFDDVETIMDAAVQGAGLAWLPRWLIAEHLSSGRLVEVLETQRPYGNEIYAVWPQSKHLTSKVRAAIDLLVARIPERLADTHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI1</accession>
    <name>Q1CXI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556700.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6775"/>
    <dbReference type="EnsemblBacteria" id="ABF89298">
        <property type="protein sequence ID" value="ABF89298"/>
        <property type="gene ID" value="MXAN_6775"/>
    </dbReference>
    <dbReference type="GeneID" id="41363966"/>
    <dbReference type="KEGG" id="mxa:MXAN_6775"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517608_0_0_7"/>
    <dbReference type="OMA" id="HAFRETP"/>
    <dbReference type="OrthoDB" id="991736at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="572" mass="59466" checksum="22C1FCF1E458D578" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXK5</accession>
    <name>Q1CXK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556676.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88533">
        <property type="protein sequence ID" value="ABF88533"/>
        <property type="gene ID" value="MXAN_6751"/>
    </dbReference>
    <dbReference type="GeneID" id="41363941"/>
    <dbReference type="KEGG" id="mxa:MXAN_6751"/>
    <dbReference type="HOGENOM" id="CLU_599791_0_0_7"/>
    <dbReference type="OMA" id="RFRFGMF"/>
    <dbReference type="OrthoDB" id="440618at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="470" mass="49463" checksum="17A021453093E0E0" modified="2006-07-11" version="1">MTGAPLFALLALVSTQYDGSSTVEEVSSEEVSSTSRREGAPVSAARLDEPAPPGSAHTGGVGFGFSGQLEVGGLSLPSGPRGGGQDFFARIYPSLGLTHGETFVLRLGANLRLRVVDEAPTTTEDYSGGLRREDWDELSDLGQVVRMLRIGQEGRPFFLRVEPFSEETLGRGYLVGRYSNALAPDYHPAGGSLTFVKGAVRAEILASDVLAARIFAGEALLDIGRMASDDANRFDRYLIRLSAAHDAGRAGGTSPDLTLASVGGDVALYKGERLRAWALLGGGARFTRAYTPSFGGLLGVALEGQMASGTQVSVTVQGRKQGGRFRFGMFGPDYELGRFSGVGMSETPIADEVLPSGFAGYVELSVAKGNPNELLLLGSVAAQYFGFGRTDTDVSAGFELPGGRTRALGRVVLTGLGDRPRYSAGVELRQRIVNHVYAWGSGGTVHFPQPDGTLVRGVTAGAGVGVDFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW8</accession>
    <name>Q1CXW8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6638"/>
    <dbReference type="EnsemblBacteria" id="ABF90016">
        <property type="protein sequence ID" value="ABF90016"/>
        <property type="gene ID" value="MXAN_6638"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6638"/>
    <dbReference type="eggNOG" id="COG1755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102515_0_0_7"/>
    <dbReference type="OMA" id="LHHPNYV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="22920" checksum="317A167067CDDA3A" modified="2006-07-11" version="1">MGRDDGHGAGLRRGDGVAAMVTSTHALFLGFMAALVVERLVELVLSKRNAARAFARGGVETGQRHYRFMVVFHTLFLVACVAEVFLLRRGFPGAWGWAALAGAVLAQGLRYWAIATLGDRWNSRIIVVPGLAPVTGGPYRFLRHPNYVAVVLELACVPLIHGAWWTALVFSVGNAALLYVRIRAEEAALGEVYAQAFSHRPRFIPEVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY44</accession>
    <name>Q1CY44_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556487.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6557"/>
    <dbReference type="EnsemblBacteria" id="ABF87089">
        <property type="protein sequence ID" value="ABF87089"/>
        <property type="gene ID" value="MXAN_6557"/>
    </dbReference>
    <dbReference type="GeneID" id="41363762"/>
    <dbReference type="KEGG" id="mxa:MXAN_6557"/>
    <dbReference type="HOGENOM" id="CLU_1466722_0_0_7"/>
    <dbReference type="OMA" id="CYDPASF"/>
    <dbReference type="OrthoDB" id="1242755at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="20907" checksum="ADFB18CA32BAFD6C" modified="2006-07-11" version="1">MPSCLSNGGRMKTWLLLACAGVVTGCYDPASFVYGESLDGLTLQFHSPDVGIYPDQSVLDDPNNPFRSSTPGAETKWDIESRAGNVAAFYSWATLLAREPGGEAQFYVGNNLLAIYQNGEARQEDLPQVRLQAIRAYQTMLDSFPDAVTYDATGTYAYDLATPAYKGIVEMEGAVQGGWVLMSTAGGGDRAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYG2</accession>
    <name>Q1CYG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556369.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87154">
        <property type="protein sequence ID" value="ABF87154"/>
        <property type="gene ID" value="MXAN_6437"/>
    </dbReference>
    <dbReference type="GeneID" id="41363646"/>
    <dbReference type="KEGG" id="mxa:MXAN_6437"/>
    <dbReference type="HOGENOM" id="CLU_1842974_0_0_7"/>
    <dbReference type="OMA" id="FWRIRFG"/>
    <dbReference type="OrthoDB" id="1906781at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188043" evidence="2">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="14726" checksum="12868D1346D4660A" modified="2006-07-11" version="1">MPPIRFRIVPRFLLPGAILASMACATGPTGRPPAPPSSAAVQTELGARDVVQAGEEYARNNSLVLAEAGEAVEIRPNFWRIRFGLADRPGRVLEVEFDELARRVVNARELEVIPENPGDSALGGSGPVPAAGQPRGPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYH5</accession>
    <name>Q1CYH5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556356.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6424"/>
    <dbReference type="EnsemblBacteria" id="ABF91907">
        <property type="protein sequence ID" value="ABF91907"/>
        <property type="gene ID" value="MXAN_6424"/>
    </dbReference>
    <dbReference type="GeneID" id="41363634"/>
    <dbReference type="KEGG" id="mxa:MXAN_6424"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_11_2_7"/>
    <dbReference type="OMA" id="CYLETMP"/>
    <dbReference type="OrthoDB" id="1823496at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="18528" checksum="E96ED1C792665D83" modified="2006-07-11" version="1">MSTEELTLRRIESRDDAAVAGIIRTVMPEFGADGPGFAIHDPEVSAMSAAYARPRHVYFVVERAGRVIGGGGIAPLEGGDAGVCELRKMYFLPEARGLGQGERLLRRCLEFAREAGFQRCYLETLAGMQQAQKLYRRMGFEPLCAPMGSTGHFGCDHWYARDLSKPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYR9</accession>
    <name>Q1CYR9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556262.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6329"/>
    <dbReference type="EnsemblBacteria" id="ABF93052">
        <property type="protein sequence ID" value="ABF93052"/>
        <property type="gene ID" value="MXAN_6329"/>
    </dbReference>
    <dbReference type="GeneID" id="41363544"/>
    <dbReference type="KEGG" id="mxa:MXAN_6329"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643768_0_0_7"/>
    <dbReference type="OrthoDB" id="1105544at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="46057" checksum="1E0FF215E649F02A" modified="2006-07-11" version="1">MGNLSSSAEMVVRVPPVSAPLDLERVRRKVEAGEILSDAELALLRAEAQRGTGSALRLALAHALINAGAEREALPLLETLRRDFPRDLPVRLGLARALLGLERHGDAERLLTEVLAQSPGDPEVLKVLAVLGLRRGEADKARAYVADALARDPFDAEARLLKEELESVDLPPPSVPQEQVLRPEFTAALTAALGRARVAFRRQGKDLLVKLATGGVGRVDVGSLYAAYQESPGTQGLTAYADALAARLGGLSSGLSAEVAALEARLRPVLRPADFAARAVGALHRPGPAGLEVFYVLEDAEFVRYLPEAALAPAGLTPESADAAAWRNLASRLAPVRPVLVDQGEVRLAEAFSGLWAVAEGDGHDAARLLLPSQREELALLAGEGPLRVALGRRELVLVCRESDAAACEALARLMPSPDGIPGTFRLTEEGLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU2</accession>
    <name>Q1CYU2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556239.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6306"/>
    <dbReference type="EnsemblBacteria" id="ABF85851">
        <property type="protein sequence ID" value="ABF85851"/>
        <property type="gene ID" value="MXAN_6306"/>
    </dbReference>
    <dbReference type="GeneID" id="41363522"/>
    <dbReference type="KEGG" id="mxa:MXAN_6306"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_2_7"/>
    <dbReference type="OMA" id="IGYHRLY"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF85851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="40103" checksum="176DBDD85B637C8E" modified="2006-07-11" version="1">MQTPSPALPAADERLNWLSSIPFFAVHLMCLFVFAVGAKPVDVAVCVGLYVVRMWGITAGFHRYFSHRAFKTGRVFQFILAFVGSMSAQKGVLWWAAHHRHHHRYSDQAEDIHSPLQKGFWWSHAGWILSDKYNDTRMEGIKDFARFPELVWLNRFHLVPSVLLAVALYFIGGFSMLVWGFFVSTTLLWHGTFTINSLSHIFGKRRYKTTDTSRNNWLLALLTLGEGWHNNHHFHQNTANQGWFWWEVDLSYYSLKVLSWFKVVEGLRLPSEATKFAFQKYTDEERAALAAPTRFWGASGARAQFVATKAAGDAARAASDAAKAAGDKVREALTTAADHLPTSAPPPSAMLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU6</accession>
    <name>Q1CYU6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6302"/>
    <dbReference type="EnsemblBacteria" id="ABF86753">
        <property type="protein sequence ID" value="ABF86753"/>
        <property type="gene ID" value="MXAN_6302"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6302"/>
    <dbReference type="HOGENOM" id="CLU_1925330_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="14008" checksum="7C572503D7628B34" modified="2006-07-11" version="1">MPKNRPRTRCNTSPCVDTLACRPYHSLQALTPIKKSAGPRLTWGQPLNWRILMAAKKKTAAKSATKKAAKTAKATKAAKSAKKTTARKTAGKTATKKAAAKKTTRKAAKKAPARKRTTKAKTVAAPVTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ50</accession>
    <name>Q1CZ50_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6192"/>
    <dbReference type="EnsemblBacteria" id="ABF90080">
        <property type="protein sequence ID" value="ABF90080"/>
        <property type="gene ID" value="MXAN_6192"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6192"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347750_0_0_7"/>
    <dbReference type="OMA" id="HKSQGFG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="848" mass="92349" checksum="49A22362F097F56A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZI4</accession>
    <name>Q1CZI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6054"/>
    <dbReference type="EnsemblBacteria" id="ABF91974">
        <property type="protein sequence ID" value="ABF91974"/>
        <property type="gene ID" value="MXAN_6054"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6054"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2771573_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="69" mass="7297" checksum="BA25BE8EA6B2B7D0" modified="2006-07-11" version="1">MGQVRRMYGAEQWLTTARLCRACGGPAEGEASQGPTSAALANALFDATGARPRELPLIPERLAAALQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY6</accession>
    <name>Q1CZY6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5900"/>
    <dbReference type="EnsemblBacteria" id="ABF90610">
        <property type="protein sequence ID" value="ABF90610"/>
        <property type="gene ID" value="MXAN_5900"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5900"/>
    <dbReference type="eggNOG" id="COG4994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141608_2_0_7"/>
    <dbReference type="OMA" id="VRYTRTW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="15261" checksum="FC7621DDE2F1D07C" modified="2006-07-11" version="1">MQQPEAPPRTSPQTRSAMLPEEDFLAAEEALRRAMLSSDVAALDALLSDDLLFVSHTGRVLDKESDLESHRSGALRLTRVDFTDTHFRYLSAGAVVVVHAALSGEFQGTRFEGNFRYTRVWQVVDNAPQVVAAQCTAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D090</accession>
    <name>Q1D090_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555747.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5796"/>
    <dbReference type="EnsemblBacteria" id="ABF86696">
        <property type="protein sequence ID" value="ABF86696"/>
        <property type="gene ID" value="MXAN_5796"/>
    </dbReference>
    <dbReference type="GeneID" id="41363039"/>
    <dbReference type="KEGG" id="mxa:MXAN_5796"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132649_0_0_7"/>
    <dbReference type="OMA" id="ATRKMVQ"/>
    <dbReference type="OrthoDB" id="1482842at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="153"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="27349" checksum="01E5D75FFF352A54" modified="2006-07-11" version="1">MTTTTAPLTPAKRRWRNFLLETGFQLKLTAYIVSVTLVLSALLGVFLVRGAQALMRETATAVEARSRAAEVSRELSGATLSNELLTRMDDPTFEASFREKAGAIDAAYEAERAAIVAQRAELERQQKLTWWALGGFLVAFIAVVGLGTIVVTHKVAGPLFRIRRMVQEVHDGRLRPPQHGLRDGDDLQDLFDATRKMVQRLREQNEEDARTLANVLLAAERSGASPELIHELRALDARYRTRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H0</accession>
    <name>Q1D0H0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D0H0"/>
    <dbReference type="STRING" id="246197.MXAN_5715"/>
    <dbReference type="EnsemblBacteria" id="ABF89039">
        <property type="protein sequence ID" value="ABF89039"/>
        <property type="gene ID" value="MXAN_5715"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5715"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="QMRLHGQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="227"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="43564" checksum="AC346D2830F70FD7" modified="2006-07-11" version="1">MRLTWSPCRGGVMLETTETATYRPRVLAVDVESGGMERLCSILAPAGYDVLTASGLAAAAAAHQSADLVLLDVERPGTDGLATYRRLQDALGSPALPVLMLTPSADRETRREVLEAGVDDLLITEPLDPLELKVRIHTLLELKAHRERGGQRAEALQDPRVRWVEMERLARVGTLAADVAQNLGRVGEGLQRALEHVRTRALQGLPPDADELKKLGVAGEQMRLHGQHLLSLGTTNPKDIQRFDLRDLVPAVVERMRDAGRLGTAEVKVQLPDEAIAVVFNRRQLEQVLVELLANAVDAVEDVTDRPRRIHVGVELPDIFGDFGPRLYVKDTGIGIFEDELQAVFEPYYTTKAPEKGAGLGLTVARTLVEAMGGAVTVHSRVNLGSTFTVELPEQTSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0I4</accession>
    <name>Q1D0I4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555653.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5701"/>
    <dbReference type="EnsemblBacteria" id="ABF86003">
        <property type="protein sequence ID" value="ABF86003"/>
        <property type="gene ID" value="MXAN_5701"/>
    </dbReference>
    <dbReference type="GeneID" id="41362946"/>
    <dbReference type="KEGG" id="mxa:MXAN_5701"/>
    <dbReference type="eggNOG" id="ENOG50337NU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034098_0_0_7"/>
    <dbReference type="OMA" id="DLMRLTH"/>
    <dbReference type="OrthoDB" id="831948at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="29821" checksum="7F9AE19A4085096D" modified="2006-07-11" version="1">MAKSPNYIKAAFMMPANLVGLGTAAASAAMTGEPLPMLVALGLEGLYLGVMSSMKRFQRAVRANTLDDPEAARKALDALQADLAPSQREHYQQLVGLKEKILANYRKLPGGKVLEADSEPRLDALLTSFLRLISTLNQYRTYLNSSDREHLQREVAELEVDVAGETNPRLKDVKQNRVDILRKRLARFEQAGESREVVSHQLAGIEDLMRLTHEQSVAIRDPEVVNRQLTMLSAEAEATEESVRQMEQFLEFSEETRGPLPHGSRVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0S2</accession>
    <name>RSMH_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">MXAN_5612</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555566.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0S2"/>
    <dbReference type="SMR" id="Q1D0S2"/>
    <dbReference type="STRING" id="246197.MXAN_5612"/>
    <dbReference type="EnsemblBacteria" id="ABF86325">
        <property type="protein sequence ID" value="ABF86325"/>
        <property type="gene ID" value="MXAN_5612"/>
    </dbReference>
    <dbReference type="GeneID" id="41362858"/>
    <dbReference type="KEGG" id="mxa:MXAN_5612"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_7"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000318877" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="304" mass="32208" checksum="9B601649D0D81B6E" modified="2006-07-11" version="1">MTASDFQHQTVLLREAVDLLRPADGRVIIDGTLGGGGHSEALLASGATVVGVDRDPVALAAATARLGANPRFQGRAGNFAELPRVAADLLPVDGVLVDLGVSSPQLDVAERGFSFSKDGPLDMRMGPDGPTAAELIATTDERELVRILKDYGEEPFARPIARELKKALPTRTLEAAEVVKRAVPRKAWPNRIHVATRTFQALRMAVNGELEALDALLAAIPGLLKVGGRAAVIAFHSLEDRKVKEAFRALAGRCTCPPGLPVCVCSGVGDFALVTKKAVAASEAEVEANPRSRSAHLRVVEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D151</accession>
    <name>Q1D151_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555437.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5479"/>
    <dbReference type="EnsemblBacteria" id="ABF90244">
        <property type="protein sequence ID" value="ABF90244"/>
        <property type="gene ID" value="MXAN_5479"/>
    </dbReference>
    <dbReference type="GeneID" id="41362734"/>
    <dbReference type="KEGG" id="mxa:MXAN_5479"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_4_7"/>
    <dbReference type="OMA" id="NQGCTFM"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="20244" checksum="FCA1C504DDBBD868" modified="2006-07-11" version="1">MHGEKPFLPREVLIGTPESEVMFSNIRRAMRLTVELNKRTFDDAEEIRTLFSELTGRNVDSTFSLIPPFYTDHGVNIRVGRNVFINQCCTLMDIGGIDIADDVMIGPKVNIITSSHPLEPARRRASAVAKPIVLERNVWIAAAVTILPGVTVGENSVVGAGAVVTEDVAPNSFVAGVPAKLVRHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D152</accession>
    <name>Q1D152_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5478"/>
    <dbReference type="EnsemblBacteria" id="ABF85979">
        <property type="protein sequence ID" value="ABF85979"/>
        <property type="gene ID" value="MXAN_5478"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5478"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2494674_0_0_7"/>
    <dbReference type="OMA" id="DVIHPDQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9834" checksum="8BDDA35148A33155" modified="2006-07-11" version="1">MWDQIKARHSNWQNEVMVMLTVTHETPYGLYTVKSGDTLSKLAKDIYGDMKLYPKIFEANKDQLKDPDKIKVGQVLKLPPKSIANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D172</accession>
    <name>Q1D172_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5458"/>
    <dbReference type="EnsemblBacteria" id="ABF92133">
        <property type="protein sequence ID" value="ABF92133"/>
        <property type="gene ID" value="MXAN_5458"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5458"/>
    <dbReference type="HOGENOM" id="CLU_1711278_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="17168" checksum="52A8FE085869CB56" modified="2006-07-11" version="1">MRHSWEWKSQRPSPGGAWRRRKAASFRWFCAATSSRRRRSRTTRCRRATGSETEASSSHERIHAWRRCDSKSSPSDSASCTYTRTSSSEKMPRSTTLRTTGSSRSRVHPGSAAEGSARSAVTSCATRLSIAALRNELICDSRIRNNVETVPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1E4</accession>
    <name>Q1D1E4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555344.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5379"/>
    <dbReference type="EnsemblBacteria" id="ABF91343">
        <property type="protein sequence ID" value="ABF91343"/>
        <property type="gene ID" value="MXAN_5379"/>
    </dbReference>
    <dbReference type="GeneID" id="41362647"/>
    <dbReference type="KEGG" id="mxa:MXAN_5379"/>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_7"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30429" checksum="D114A619AB468313" modified="2006-07-11" version="1">MNRPSRMKMAAIHAGLTLLCMATLYPVLWVVKMALSPTDGLALTANPFPETVTLEHFRQVLSGTDAAGRWVFGRQLLASIVVAGATTLVGLTLAVSAAYALSRFRFPGKEGGMQALLVTQMFPATLMMVPIYSILQKLHLLDSLTGLVLVYATTALPFCIWNLKGYFDTLPRELEEAAVMDGASTFQVFVRVVLPLARPALAVTALFSFMTAWNEFILAATLLNDPSRFTLPVALQRFVGEHKVEWGKFAAGALIVSAPVMALFFALQKHLVGGLTAGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1J0</accession>
    <name>Q1D1J0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555298.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5333"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91263">
        <property type="protein sequence ID" value="ABF91263"/>
        <property type="gene ID" value="MXAN_5333"/>
    </dbReference>
    <dbReference type="GeneID" id="41362602"/>
    <dbReference type="KEGG" id="mxa:MXAN_5333"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372107_0_0_7"/>
    <dbReference type="OMA" id="VFHNISP"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="171"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="569"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="746" mass="82309" checksum="E6AE6E71DB77F004" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R7</accession>
    <name>Q1D1R7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proto-oncogene c-fos N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5254"/>
    <dbReference type="EnsemblBacteria" id="ABF88005">
        <property type="protein sequence ID" value="ABF88005"/>
        <property type="gene ID" value="MXAN_5254"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5254"/>
    <dbReference type="HOGENOM" id="CLU_2602348_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="79" mass="8382" checksum="10FB9DE6D151744D" modified="2006-07-11" version="1">MTRSAGYSPAGRSSFFTKPSTSVENARALACSSMSTPLSVTFIATSEWWDRPSLIGRKVAPRQPLPLGFPAPASRGPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V2</accession>
    <name>Q1D1V2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase, molybdopterin-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5219"/>
    <dbReference type="EnsemblBacteria" id="ABF91000">
        <property type="protein sequence ID" value="ABF91000"/>
        <property type="gene ID" value="MXAN_5219"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5219"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032973_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="5">
        <location>
            <begin position="116"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="4">
        <location>
            <begin position="434"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="67435" checksum="712D25265C377EFD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y2</accession>
    <name>Q1D1Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal subunit interface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfiA</name>
        <name evidence="2" type="ORF">MXAN_5188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555159.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5188"/>
    <dbReference type="EnsemblBacteria" id="ABF91441">
        <property type="protein sequence ID" value="ABF91441"/>
        <property type="gene ID" value="MXAN_5188"/>
    </dbReference>
    <dbReference type="GeneID" id="41362470"/>
    <dbReference type="KEGG" id="mxa:MXAN_5188"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142879_2_0_7"/>
    <dbReference type="OMA" id="GGVDKEC"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13207" checksum="F8D4293BA113D6CB" modified="2006-07-11" version="1">MKVLLRGVHLNLSDALKSYVDEHLVRHIERFADDEAAEIDISLVDTNGPKGGMDKECRVTVRLPGLSSVHVTETADSLFPAIDASRDRLETSLKRMLGKRRDVHTNGLPEDVAVDVPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y6</accession>
    <name>Q1D1Y6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5184"/>
    <dbReference type="EnsemblBacteria" id="ABF88477">
        <property type="protein sequence ID" value="ABF88477"/>
        <property type="gene ID" value="MXAN_5184"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5184"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019564_2_1_7"/>
    <dbReference type="OMA" id="WMGPRGL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="368"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="578" mass="62781" checksum="8E7FEECAEECEB1A3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E4</accession>
    <name>Q1D2E4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555000.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5024"/>
    <dbReference type="EnsemblBacteria" id="ABF86981">
        <property type="protein sequence ID" value="ABF86981"/>
        <property type="gene ID" value="MXAN_5024"/>
    </dbReference>
    <dbReference type="GeneID" id="41362309"/>
    <dbReference type="KEGG" id="mxa:MXAN_5024"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553021_0_0_7"/>
    <dbReference type="OMA" id="WGMAEAY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188164" evidence="2">
        <location>
            <begin position="19"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="493" mass="51454" checksum="A6B6263A2B256E48" modified="2006-07-11" version="1">MLKTVKHRSFLVRGAALALTLACMTGCGDDDEPTPTPDAGTNTDAGTDAGTNPTPDAGTGALDSDIAVVRFNEDGTHDTTFGAGGVTHVDFGTGRDGTRDSLWDVRVDGTDRIVLFGNKRADGTRVDTDRVVARLTATGALDTTFGSTETPNGFSVLNLSNLNDGMRYGFIQPDGKIMTSGYTSMPTGVGAQAANRIVLQRLNDNGKADDSFGWKGVVTSAPFQAQSETNPEWGMAEAYAAGMQSNGSYVTTGYGRSASSGKVDLVSFRYTSTGALDPTWGTGGAVVLDLVGDDDRGRNLVVLNDDRVLHVGSGSLGAQNIQALLLMQTQDGQPDTTFAPEGYKTFSLDRPEQAFFGVAKSSDGNWAAAVGYRAGGNQNADGILAIIPTNGSAEEVIIKATPISTTENDRFWSVAFDSTNRIYAAGFVTEGGDNGDNQMVVARFTTEGNLDTTFGTGGIAKINVATAGTEEAARGIAIQSDGKIVIGGPIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2G1</accession>
    <name>Q1D2G1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2Fe-2S cluster assembly ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554983.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5006"/>
    <dbReference type="EnsemblBacteria" id="ABF88536">
        <property type="protein sequence ID" value="ABF88536"/>
        <property type="gene ID" value="MXAN_5006"/>
    </dbReference>
    <dbReference type="GeneID" id="41362290"/>
    <dbReference type="KEGG" id="mxa:MXAN_5006"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_5_2_7"/>
    <dbReference type="OMA" id="SACGGVC"/>
    <dbReference type="OrthoDB" id="1837979at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13490" checksum="863D2B052E9DDDF0" modified="2006-07-11" version="1">MPKVTFKSPLAEVSADVPTGTTLLDAAEACGAQVGHSCGGVCGCSTCHIWVRKGLDSLSEQTDAEADRLDMGFDVRPYSRLSCQTELGAEDILVEITEESLTAFMDENPVLRRSLEAEGKWPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z3</accession>
    <name>Q1D2Z3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate ABC transporter, permease protein CysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW</name>
        <name evidence="11" type="ORF">MXAN_4819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4819"/>
    <dbReference type="EnsemblBacteria" id="ABF86761">
        <property type="protein sequence ID" value="ABF86761"/>
        <property type="gene ID" value="MXAN_4819"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4819"/>
    <dbReference type="eggNOG" id="COG4208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_7"/>
    <dbReference type="OMA" id="NEYNFVA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29764" checksum="B5B6780E7A5F2C9E" modified="2006-07-11" version="1">MRRSARSLSGPAFVRWGLIGAAVLLLGVFLIVPLVAVFTFAFQKGWEAYVAALTYPTALAAMRLTLLAAAIAVPFNLVFGLAASWLIARFQFRGRSLLMTLIDLPFSVSPVIAGLIFVLLFGRQGWLGPWLLDHDVRVIFAVPGIVLATVFVTFPFVAREVLPVMEAQGSDEEEAALTLGASGWRTFLTVTLPKVKWGVLYGVILCNARAMGEFGAVSVVSGHVRGVTTTLPLHAEILYNEYDLAGAFAVASLLTLLALVTLVVKKFVEWRSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3F8</accession>
    <name>Q1D3F8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554641.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4649"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92065">
        <property type="protein sequence ID" value="ABF92065"/>
        <property type="gene ID" value="MXAN_4649"/>
    </dbReference>
    <dbReference type="GeneID" id="41361949"/>
    <dbReference type="KEGG" id="mxa:MXAN_4649"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515712_0_0_7"/>
    <dbReference type="OMA" id="TWRVWNL"/>
    <dbReference type="OrthoDB" id="268932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="53048" checksum="869677B6F33ACF47" modified="2006-07-11" version="1">MPILLTITQGLQQGRELTFEAAEVNIGRTSENDLVLHDHGVSRRHARIVLRGDKYFVADMGSSNGTVLNGGLLSGEQQLRDGDKIGVGPVEFTFVWVPPEGDEDATRPIRRGDPVPALDPDATRPIRLNDPIPAESGIVLPEGHPTAQQPAVVPVRPGTAAVAKAEPGAGQTAAERARRRRELAGSQAGRLLLWWGQLSTPARLGVGAVGGGLVLALVGVLAVFFMPKGEGRASGVEPEDLGFEVISDSFGVGEGVTWENPEHKSFAFQFVTPTRAVAVVHYMASGISKEEVALVVNGVDVGWVPPDVNAVTERGLEQILPPSALKRGELNSIVFDNVRNPPGQDTWRVWNLRLEIIPVPELPQDELLAKARQYVVAGARFYESRDVGAENLFKAWQQYRFAWVTLEALDTKPDIYQDVRFQLGEVATELDHKCSQLMLDFQRSVQYRNARTARAALQEMGRRFPTAEHRCHNLGLQLAYEHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M8</accession>
    <name>Q1D3M8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554572.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4577"/>
    <dbReference type="EnsemblBacteria" id="ABF90012">
        <property type="protein sequence ID" value="ABF90012"/>
        <property type="gene ID" value="MXAN_4577"/>
    </dbReference>
    <dbReference type="GeneID" id="41361877"/>
    <dbReference type="KEGG" id="mxa:MXAN_4577"/>
    <dbReference type="eggNOG" id="ENOG5032KI9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102483_0_0_7"/>
    <dbReference type="OMA" id="TPACREH"/>
    <dbReference type="OrthoDB" id="1201001at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="22527" checksum="0A4586A9322AE2EC" modified="2006-07-11" version="1">MTPSEKLVFNQTVEALFVRALENRLTPACREHLRRAGLELDQKLERAYTLEQWKEFLRIAAGHVYGGVPAEAAYYSLGERFMDAYFGTFFGRALLGVVRLAGPRRMLLRAGMGFRAGNNFSVVEIVERSPTSVELRMNDVLADLPTFSAGLLARAVELCGGGRVVSIPEEFDGTAATFHIRWSEAPAEAALTATDDDSGASRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3S7</accession>
    <name>Q1D3S7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554523.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4528"/>
    <dbReference type="EnsemblBacteria" id="ABF89336">
        <property type="protein sequence ID" value="ABF89336"/>
        <property type="gene ID" value="MXAN_4528"/>
    </dbReference>
    <dbReference type="GeneID" id="41361830"/>
    <dbReference type="KEGG" id="mxa:MXAN_4528"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_2_7"/>
    <dbReference type="OMA" id="HRRFWRT"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1732"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1857" mass="198888" checksum="99F0A34C087CA75D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D419</accession>
    <name>Q1D419_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, S1C (Protease Do) subfamily</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554432.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4433"/>
    <dbReference type="EnsemblBacteria" id="ABF86091">
        <property type="protein sequence ID" value="ABF86091"/>
        <property type="gene ID" value="MXAN_4433"/>
    </dbReference>
    <dbReference type="GeneID" id="41361745"/>
    <dbReference type="KEGG" id="mxa:MXAN_4433"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_7"/>
    <dbReference type="OMA" id="EGKGPWP"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188204" evidence="3">
        <location>
            <begin position="24"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="262"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="47744" checksum="77F862AC096E2D4F" modified="2006-07-11" version="1">MKHAVMRWSLLVMALLTSGTANADMARRRDAIVEVVQKVSPAVVYIGTEQEVESRFRGRRSPLEEFFGGMGAEPERQRISGLGSGAIIDPSGIIVTNDHVIRGASAIHVILADGRSFDAEVIGSDAANDLAVLKVNAKEALPIAKLGTSSDLMIGETVVAIGSPFGLSKTVTAGVVSAVGRTFRADNRVYNDFVQTDAAINPGNSGGPLLNVDGEIIGINTAIFGGGAQGIGFAIPADKVRRIVDELTRFGKVRPAWVGIDTADLPVRVARQLGWDRAYGALVTAVEAGSPAAEAGVKRGDVVAELGGSRIQDAEDFDTRVRGYPARSAFPVVLFREGGLRTVQVTPVEFPARMVEGLAWERLGLRVKEIRGGLAVSGVRQGSAAADIGLEPGDIILRVNNQPVTTNDAFRESLLTARRGRSVLLLVRRGRYGYHVTLPFEREAGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D424</accession>
    <name>Q1D424_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase inhibitor YacG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yacG</name>
        <name evidence="3" type="ORF">MXAN_4428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GyrB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA gyrase inhibitor YacG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4428"/>
    <dbReference type="EnsemblBacteria" id="ABF92130">
        <property type="protein sequence ID" value="ABF92130"/>
        <property type="gene ID" value="MXAN_4428"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4428"/>
    <dbReference type="eggNOG" id="COG3024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2343775_0_0_7"/>
    <dbReference type="OMA" id="GNDEPTH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00649">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005584">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36150">
        <property type="entry name" value="PTHR36150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03884">
        <property type="entry name" value="YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="97" mass="10751" checksum="C7B6C30CD6A9E7EE" modified="2006-07-11" version="1">MAGASYGKASTKHPGSRERQRLSRTPSTMSTLTCPICQKPVPPRGENAAFPFCSKRCRAVDLGRWLGEEYRVPDRQADEQEDELPADSHPARQHGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4L0</accession>
    <name>Q1D4L0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90031">
        <property type="protein sequence ID" value="ABF90031"/>
        <property type="gene ID" value="MXAN_4238"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4238"/>
    <dbReference type="HOGENOM" id="CLU_3218989_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4703" checksum="810078460458CE70" modified="2006-07-11" version="1">MGCHEFLSQLARHHGTNAASRKKQSRGMRVEGALPAQASAEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4L7</accession>
    <name>Q1D4L7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine oxidase ThiO</fullName>
            <ecNumber evidence="3">1.4.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiO</name>
        <name evidence="3" type="ORF">MXAN_4231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.19" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554234.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4231"/>
    <dbReference type="EnsemblBacteria" id="ABF89810">
        <property type="protein sequence ID" value="ABF89810"/>
        <property type="gene ID" value="MXAN_4231"/>
    </dbReference>
    <dbReference type="GeneID" id="41361548"/>
    <dbReference type="KEGG" id="mxa:MXAN_4231"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_7"/>
    <dbReference type="OMA" id="CRRLEPM"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043799">
        <property type="term" value="F:glycine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="372" mass="39360" checksum="D35C59EE1371D576" modified="2006-07-11" version="1">MQVADVIIVGGGIMGCGIALRLRQAGVRVVVLERSIPGAEASSAAAGMLAPQMESDGPGAFLELCLRSRGLYPAFAAELRELSGVDVAYRPCGILKVAFNEASLHHLDATVAWQRGMGLRAELLDGAAARALEPRLSAKAVGAAHFPDDHQLDNRLLVRALTMAAARLGAEFRSGYVRGVVQEGGRAVGVDLDGELLRADAVVLAAGSWSALVHGAGVEARAVRPARGQMVQFQTRLPLLDRIVTSEKGYLVPRADGRVIAGSTMELVGFDKQVTAAGLARILDMALELCPELGSAPVTETWAGFRPWTEDKRPYLGEGPVPGLFLATGHFRNGILLAPITAKLVAQAVLGERPAVDLAPFRYDRSPAQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4P0</accession>
    <name>Q1D4P0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554211.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4208"/>
    <dbReference type="EnsemblBacteria" id="ABF87066">
        <property type="protein sequence ID" value="ABF87066"/>
        <property type="gene ID" value="MXAN_4208"/>
    </dbReference>
    <dbReference type="GeneID" id="41361525"/>
    <dbReference type="KEGG" id="mxa:MXAN_4208"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061007_0_0_7"/>
    <dbReference type="OMA" id="PNSANTY"/>
    <dbReference type="OrthoDB" id="1159210at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="28751" checksum="CE4E75465202FF0D" modified="2006-07-11" version="1">MKRLGKVGLLVGALTLGGAVVGCKAEDDTAKKQRIVGSDHLSKKEFKEAAAAYALSLQADPKQEKVWEKKAFAHMQMGQMNEAAEAVLKMGELKTTPAEKAEIYRTLASMYMTGGTTEDAEKYFNEALKLEPKDEASLGWIAEIYAQRGGARSMGAPIIKESLEKSLSYYDQVIAINPNSANTYLNKRVVMGRLMEFERQQKEMALSEAAENAKNKEVVAEATARADEHQKRMDEYQVQFAEMTKKFGEAQKAAKAAAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Y2</accession>
    <name>Q1D4Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4113"/>
    <dbReference type="EnsemblBacteria" id="ABF85884">
        <property type="protein sequence ID" value="ABF85884"/>
        <property type="gene ID" value="MXAN_4113"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4113"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045354_1_0_7"/>
    <dbReference type="OMA" id="PTWRLMS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030192">
        <property type="entry name" value="YbdG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30414">
        <property type="entry name" value="PTHR30414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="46928" checksum="216DE77DBDCBEDF8" modified="2006-07-11" version="1">MTILPWLSALQRQLEPWPMAWPVTVLAALLGVAWLANFVTKKILLRGLHHVIERLSGPEHDTRLALRAVERLSNVVPSVVIASGLSLVPGLPAALVVLLQGACHVWTVATLALAASHAFDASNAFYERRPDARNKPIKGYLQVAKIIVFVLAGLSIVATLAGVKLLHVLTGLGAATAVLMLIFQDTLLSLVASVQISGDGRVRIGDWIEMPSQNADGDVIDIALHTVTVQNWDKTITTIPTKKLISDSFKNWRGMRQSGGRRIKRSIYLDQHSVRFLDDALQPRIYQFALLDDYLASKREELGQWNAQVAAVHPEPVNARRLTNLGTFRAYVERYLRTHPRINQNMTLLVRQMAPTEHGLPLEIYCFTASTAWAEYEATQSDIFDHLLAILPEFGLRVFQQSSDAMFMGLQRAQDCATPVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D551</accession>
    <name>Q1D551_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554051.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4043"/>
    <dbReference type="EnsemblBacteria" id="ABF89947">
        <property type="protein sequence ID" value="ABF89947"/>
        <property type="gene ID" value="MXAN_4043"/>
    </dbReference>
    <dbReference type="GeneID" id="41361374"/>
    <dbReference type="KEGG" id="mxa:MXAN_4043"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132652_0_0_7"/>
    <dbReference type="OMA" id="VPTLMDS"/>
    <dbReference type="OrthoDB" id="1316028at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA" evidence="1">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26538" checksum="287563B25FB85F3A" modified="2006-07-11" version="1">MAPVGRRRGWNRENPEEFQLVTSTAMSNSAPSVEDAPQPVVGAARYLAVPTLMDSLLHDVRNPLNALAIHLEVLSEKLKVETGSVPPSQEKNLKAMRDQIQRVDGILKLFSDFVVFRGGVPGVADLSEATTRALGVLGHEGRKRRVQVQAAVEAGVQIRLQDTSELGFFLIQTLLRAFRRAENGGSIRVTVRGDETSAVLEVEDSAGACPEPLPEAVAALQLRCSQLGVDLHVRAGLCRLSFSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5H7</accession>
    <name>Q1D5H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mutator mutT protein</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutT</name>
        <name evidence="3" type="ORF">MXAN_3916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553926.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3916"/>
    <dbReference type="EnsemblBacteria" id="ABF90152">
        <property type="protein sequence ID" value="ABF90152"/>
        <property type="gene ID" value="MXAN_3916"/>
    </dbReference>
    <dbReference type="GeneID" id="41361247"/>
    <dbReference type="KEGG" id="mxa:MXAN_3916"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_11_2_7"/>
    <dbReference type="OMA" id="MPYTPIV"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003562">
        <property type="entry name" value="Mutator_MutX_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01402">
        <property type="entry name" value="MUTATORMUTX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="18300" checksum="1967173C1228DEC5" modified="2006-07-11" version="1">MPYTPIIGTLGYVMSPDGHRVLLVHRNARPDDAHYGKFNGLGGKMERDEDVAACMRREIREEAGIECTQMVLRGTISWPGFGKHGEDWLGFVFRIDRFEGTPLERNPEGSLSWVPVADIQGLNLWDGDRHFLPLVFDADPRPFHGVMPYSGGRALSWSFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z4</accession>
    <name>Q1D5Z4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553760.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3747"/>
    <dbReference type="EnsemblBacteria" id="ABF92629">
        <property type="protein sequence ID" value="ABF92629"/>
        <property type="gene ID" value="MXAN_3747"/>
    </dbReference>
    <dbReference type="GeneID" id="41361080"/>
    <dbReference type="KEGG" id="mxa:MXAN_3747"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053649_0_0_7"/>
    <dbReference type="OMA" id="AWEKNWG"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="213"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="43898" checksum="FA6E91247B2256D9" modified="2006-07-11" version="1">MALHAEPTHASSSMPSDVQVTPVRGEAERMQFIRLPYALYRSDPHWVPPLEMERRDFLDPKKNPFFEYGELELFLARRGPDVVGRIAAIRNPRHMEIHGTKEGFFGLFECVNDAGVARTLLESAATWLRLRGMDAMLGPANLSSNQDWGLLIDGFDTPPAVMMPHNPPYYAALLEACGLTKAKDLYAYELSSSAQPPEKVVRIAEKIRVRDGVVVRPVNMKDLDAEVKRIRDIYNSAWEKNWGFVPFTDAEFDHLAKELKTVVRPDLALMAEVQGEPVAFSLTVPDANQAIRAANGRLTTFGLPIGLVKLALASRRINRLRLIILGIKEGYRRRGLDAILYLDTLRTAKRLGYVGGEISWTLEDNHLVNRAIESMGAQRSKTYRVYTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D658</accession>
    <name>Q1D658_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553696.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3678"/>
    <dbReference type="EnsemblBacteria" id="ABF86792">
        <property type="protein sequence ID" value="ABF86792"/>
        <property type="gene ID" value="MXAN_3678"/>
    </dbReference>
    <dbReference type="GeneID" id="41361013"/>
    <dbReference type="KEGG" id="mxa:MXAN_3678"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_7"/>
    <dbReference type="OMA" id="NIVAVMS"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="35326" checksum="43613C9E6AF87BA6" modified="2006-07-11" version="1">MDLARELTDFLGAVEQRLGSTLVDGDAGPDVKGDTLMEAARHLCLGSGSKRARPMLARLFGGAVGVPAERLVDVAVAAELIHSASLLHDDVVDAGMFRRGRPTVNARWGNIVAVMSGDLILSTGLFQLSQLDARLTRSALSVVSEMTRAAIAEVEARGDLDLPLNRLRFIAEGKTGSLFGWCGNAAATLAEHPEAVERFDGFGRHLGVAFQIADDIRDILGTDVGKPRYADVHSRTPSMPILLAVAKDESLRRKLKDAWAFSAITPDRTKEIGAAIEATGAVDASMARMNVEIEAALDKLGHFAKEPAGAELVSWARKLSAGIAEQVQGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D694</accession>
    <name>Q1D694_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553660.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3642"/>
    <dbReference type="EnsemblBacteria" id="ABF85885">
        <property type="protein sequence ID" value="ABF85885"/>
        <property type="gene ID" value="MXAN_3642"/>
    </dbReference>
    <dbReference type="GeneID" id="41360979"/>
    <dbReference type="KEGG" id="mxa:MXAN_3642"/>
    <dbReference type="eggNOG" id="COG3200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026885_0_1_7"/>
    <dbReference type="OMA" id="KVMMQMA"/>
    <dbReference type="OrthoDB" id="1371606at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="49866" checksum="BB4F46689E3919AB" modified="2006-07-11" version="1">MTNPTWTPDSWRHKPVKYMPEDYPDAQALVQTEAELSRLPPLVFADETRQLTARLARVAEGKAILLQGGDCAESFKEFTTDNIRDTYRLLLQMAMVLTFAGNRPVVKVGRIAGQFAKPRSSPMETLGGVTLPSYRGDIINGMEFDAQARTPDPRRLLKAYHQSSATLNLLRAFAQRGYEELAEPQRWPQGGINRLLADRILESLSFMRALGVSPEPRSGSNAIDFFTSHEALLLNVEEAMTRAEPDGSGWYDSSAHMLWIGERTRQLDGGHVEFMRGIQNPIGIKCGPTMEPDEVLRLMDLLNPQGIPGRITLIGRFGADLVAERLPRLMAATRRDGRPVIWSIDPMHGNTHKAGNGYKTRSFDRILTEVCGFMDAAAAEGVHPGGLHLEMTGQNVTECLGGPQPVTEDDLSSRYHTHCDPRLNADQALQLAFLVAESMPSLRTHEARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6E8</accession>
    <name>Q1D6E8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553611.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3585"/>
    <dbReference type="EnsemblBacteria" id="ABF89080">
        <property type="protein sequence ID" value="ABF89080"/>
        <property type="gene ID" value="MXAN_3585"/>
    </dbReference>
    <dbReference type="GeneID" id="41360931"/>
    <dbReference type="KEGG" id="mxa:MXAN_3585"/>
    <dbReference type="HOGENOM" id="CLU_2166706_0_0_7"/>
    <dbReference type="OMA" id="RHRKMID"/>
    <dbReference type="OrthoDB" id="1684659at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="14782" checksum="FEA85131D1AF5446" modified="2006-07-11" version="1">MLHPRSNLLHHLTGGEEAMSDKRKNKRAPLDIYLNKYMGGVPYMSRAADISQEGLSLARLLEPQHEAKRIGLQFQLPGSEEIIYAEGEVVREWAELGAKRERSGVRFTLLTDRHRKMIDAYVDRHGNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z7</accession>
    <name>Q1D6Z7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ORF">MXAN_3379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553412.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3379"/>
    <dbReference type="EnsemblBacteria" id="ABF91578">
        <property type="protein sequence ID" value="ABF91578"/>
        <property type="gene ID" value="MXAN_3379"/>
    </dbReference>
    <dbReference type="GeneID" id="41360726"/>
    <dbReference type="KEGG" id="mxa:MXAN_3379"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_7"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="615" mass="68028" checksum="5CE09CE735889D6F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z8</accession>
    <name>Q1D6Z8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553411.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3378"/>
    <dbReference type="EnsemblBacteria" id="ABF90837">
        <property type="protein sequence ID" value="ABF90837"/>
        <property type="gene ID" value="MXAN_3378"/>
    </dbReference>
    <dbReference type="GeneID" id="41360725"/>
    <dbReference type="KEGG" id="mxa:MXAN_3378"/>
    <dbReference type="HOGENOM" id="CLU_1377403_0_0_7"/>
    <dbReference type="OMA" id="QNCFAGY"/>
    <dbReference type="OrthoDB" id="1236166at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188327" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="8"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="21353" checksum="B653CBFBDEB369D2" modified="2006-07-11" version="1">MKKSQLIAALALLSSPVLAATPPEGVAFEPRRGFFTETDIGVFFTVGGENVYSNAQTYLQLGVGYDLTEKLSLGAHFGLGSSAQNCFAGYLPGTETCALSDNFTMAFFNLSAAYHVRVMDRLFLTPKVVAGYTRLDPAPVDPDEGDPGRAVNAPNAGLGFGVEYATGMDHFSVGADLLARYIIGPNITSFAIFPKVKYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D711</accession>
    <name>Q1D711_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553398.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3365"/>
    <dbReference type="EnsemblBacteria" id="ABF88901">
        <property type="protein sequence ID" value="ABF88901"/>
        <property type="gene ID" value="MXAN_3365"/>
    </dbReference>
    <dbReference type="GeneID" id="41360713"/>
    <dbReference type="KEGG" id="mxa:MXAN_3365"/>
    <dbReference type="HOGENOM" id="CLU_1439656_0_0_7"/>
    <dbReference type="OMA" id="WANHVRY"/>
    <dbReference type="OrthoDB" id="1153033at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="21226" checksum="994851A22F19CB73" modified="2006-07-11" version="1">MRRGAPEVTGVELPRDSVGFTRRECPECQRPFKTRPGPMDSRAVLHKLLGFYPFENAHECVEGIPVWGCPYCGYRAEADAFLTPAQQGHLEAVARGWANHVRYEQLAHVARTLSVNPRPTFVAVEPEALPGPMEPEPDELLRVMPMLCCGEEVKVIWEWDQALHCFSCGARHDPMSGRQQVELRFVSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D762</accession>
    <name>RS14Z_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN1</name>
        <name type="ordered locus">MXAN_3312</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553348.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D762"/>
    <dbReference type="SMR" id="Q1D762"/>
    <dbReference type="STRING" id="246197.MXAN_3312"/>
    <dbReference type="EnsemblBacteria" id="ABF87653">
        <property type="protein sequence ID" value="ABF87653"/>
        <property type="gene ID" value="MXAN_3312"/>
    </dbReference>
    <dbReference type="GeneID" id="41360665"/>
    <dbReference type="KEGG" id="mxa:MXAN_3312"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_7"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000269124" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="7143" checksum="1B972546EEEF4370" modified="2006-07-11" version="1">MAKLSKIAQAKRKPKFSVRQYNRCPLCGRPRAFLRKFKMCRICLRNRALRGEVTGVTKSSW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D767</accession>
    <name>RL29_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmC</name>
        <name type="ordered locus">MXAN_3307</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D767"/>
    <dbReference type="SMR" id="Q1D767"/>
    <dbReference type="STRING" id="246197.MXAN_3307"/>
    <dbReference type="EnsemblBacteria" id="ABF89958">
        <property type="protein sequence ID" value="ABF89958"/>
        <property type="gene ID" value="MXAN_3307"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3307"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_7"/>
    <dbReference type="OMA" id="VQHRRDL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000079893" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="68" mass="7839" checksum="264EBBEFDD9FA6D2" modified="2006-07-11" version="1">MESEMATAKELKELSADDLKQRAAELRETLFQDQLKRRTGSLDNPAERTQHRRDLARVLTVLTQKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D787</accession>
    <name>Q1D787_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553332.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3287"/>
    <dbReference type="EnsemblBacteria" id="ABF91262">
        <property type="protein sequence ID" value="ABF91262"/>
        <property type="gene ID" value="MXAN_3287"/>
    </dbReference>
    <dbReference type="GeneID" id="41360640"/>
    <dbReference type="KEGG" id="mxa:MXAN_3287"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758018_0_0_7"/>
    <dbReference type="OMA" id="NALMFAW"/>
    <dbReference type="OrthoDB" id="864655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="367" mass="39241" checksum="3080A03B48638924" modified="2006-07-11" version="1">MVSAAFALGAFILVGGTVQLANPAFGIWFTELVVFLGLGWVMLRNAGWRPVLYTGLLPAPRAATVFGFLLGVANFFALVVPIQFLAQSVAPEWLTRMFDSSKLFADQTPLELAIILTGVSVAAPFCEEFFFRGIFQRGLTPPAPAPTTAPLVISAVVFSAFHLDPVGFLARTELGLLFGWLYLRTGSLWPAIGAHAANNLVSSVLFLSAKALGTDASEATSEATDPRLVLVLAAAGWAGMSALLAYARRQPGVWGPGARASDEEAQEPGPTPSLVRLMLPWVVGATVSLGLLVAVDSRGLALNFYDAQHPLPTLESPQAPALHAERKALSALRASARRGELPMEAYYEERERQIRAHRIQTGPGLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E8</accession>
    <name>Q1D7E8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553271.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3226"/>
    <dbReference type="EnsemblBacteria" id="ABF91131">
        <property type="protein sequence ID" value="ABF91131"/>
        <property type="gene ID" value="MXAN_3226"/>
    </dbReference>
    <dbReference type="GeneID" id="41360580"/>
    <dbReference type="KEGG" id="mxa:MXAN_3226"/>
    <dbReference type="HOGENOM" id="CLU_719459_0_0_7"/>
    <dbReference type="OMA" id="GLEYRYQ"/>
    <dbReference type="OrthoDB" id="533406at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="404" mass="44407" checksum="649F998D8CCD1CAF" modified="2006-07-11" version="1">MRDGDAVGVVDVGGGWRAGRRATVKGNWKKWLLAGLMFGAPAAQAATIWEPRLRLTAEERFDDDLRLGGGGTGQLMTKVTPRLGLEAKDARLTLDSFYAADLLMRHGSGRTTLDHRGGLEARHQMTRRLRLDTALRVFRVTDPSSLPRAGLARSTLPTFFTQATLGVTNRVAERLDVRAGYRFEAVRIIDVGQRAGYAHTPSIEGWYRATRRLGLGLEYRYQGFLYEGALSQSHGAALGLRYRLTRPTTFTVRAGPVRYLAPVAQQGGWVPRVNVELQREGEMFDLGVSMGHDLVGANGFTNALWADYASVMLARRFTQKFSLFGAASFFRNGQAPSLDWAVFRGAPRVSQGYAVSGGVEYRIDRRLSAQGAVDRIAQVGLADSASAVDLTRNVFAVRLVVTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7P8</accession>
    <name>Q1D7P8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative monooxygenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553172.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3122"/>
    <dbReference type="EnsemblBacteria" id="ABF87096">
        <property type="protein sequence ID" value="ABF87096"/>
        <property type="gene ID" value="MXAN_3122"/>
    </dbReference>
    <dbReference type="GeneID" id="41360483"/>
    <dbReference type="KEGG" id="mxa:MXAN_3122"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033694_0_0_7"/>
    <dbReference type="OMA" id="GYEVTLM"/>
    <dbReference type="OrthoDB" id="1077270at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smoa_sbd" evidence="2">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="440" mass="47729" checksum="F1F84E12F98DF845" modified="2006-07-11" version="1">MERIAIVGAGTAGLHLGLKLLSHGVPVTIYTEQEPSRLRVSRLLNTVAHHAPTRMRERILGVDHWSGPNADMFYIGIHVNGGPHPFSLRGRLDSPTIFVDYRQYQPRLAEDFVARGGKLEVLPVDLDVLERLAQQHALMVVATGRNGLTRLFPRVPALSPHTQPPRMLFAALLKGVRMQEPIGMNANLIPGQGEIFESQVVTADGRVPSVLIEALPGSELSRLSTQRYDEDPRAFEAMLMNFLRRFAPTTYERVDSASFGVRGPMDYLQGSFTPTVRQGWAPLSNGRFALAVGDTHVTNDPVAGQGANAGSASAFALAEHIVTALADNRPFDEVFCREAEAGSWAATAPATHWTNTLLQPPPPHVIDLLAAGSKDARVADAIATAFVTPELILSACASPENSAAFIARHRPMVREAAPPPSPLAWHPPPEEPKVTVSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Q2</accession>
    <name>Q1D7Q2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553168.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3118"/>
    <dbReference type="EnsemblBacteria" id="ABF91873">
        <property type="protein sequence ID" value="ABF91873"/>
        <property type="gene ID" value="MXAN_3118"/>
    </dbReference>
    <dbReference type="GeneID" id="41360479"/>
    <dbReference type="KEGG" id="mxa:MXAN_3118"/>
    <dbReference type="eggNOG" id="COG3251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181321_0_2_7"/>
    <dbReference type="OMA" id="QYSIWPH"/>
    <dbReference type="OrthoDB" id="2067093at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="71" mass="8418" checksum="897DA66C5B154F99" modified="2006-07-11" version="1">MTDEREDTTVYKVVVNHEEQYSIWPADRENALGWKDAGKQGLKAECLEYIKEVWTDMRPLSLRKKMEELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Y4</accession>
    <name>Q1D7Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3030"/>
    <dbReference type="EnsemblBacteria" id="ABF88445">
        <property type="protein sequence ID" value="ABF88445"/>
        <property type="gene ID" value="MXAN_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3030"/>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055978_0_1_7"/>
    <dbReference type="OMA" id="MIKSHVN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="23107" checksum="279B9169183D020C" modified="2006-07-11" version="1">MKDQEKKEAQEKAAAEVAKRKAAAPPPRATKAPKVREEDDASLFFSAMDGVQQLTHRGEAPAPNPRLPAIIDENAEALAQLSELVAGQGDFDFTGTDECIEGASPGIDRNLMRALRRGDFAIQGQLDLHGKTQSEARDALERFLGDSRRAKKRCVLVVHGRGLNSKDQIPVLKERLKGWLSEKRIGRMVLAFATARPQDGGTGAVYVLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D809</accession>
    <name>Q1D809_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553061.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3005"/>
    <dbReference type="EnsemblBacteria" id="ABF86827">
        <property type="protein sequence ID" value="ABF86827"/>
        <property type="gene ID" value="MXAN_3005"/>
    </dbReference>
    <dbReference type="GeneID" id="41360366"/>
    <dbReference type="KEGG" id="mxa:MXAN_3005"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531636_0_0_7"/>
    <dbReference type="OMA" id="TAMMDMM"/>
    <dbReference type="OrthoDB" id="1513227at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21308" checksum="615BC07461177E25" modified="2006-07-11" version="1">MADPTTSAVDTPDAEAVARLSYRRALARKKRKEREAAGEIKELNITAMMDMMTILLVFLLKSFASSSAAVTASEDVRPPVSSTRATPKDTVAVTITPRNVLVGEREVLRLQNGQFPADKLQGRLVLPLDAQLKKEVEKLKYIAARNPSAPFSGELSVIADKKIPYDMLLTVLYTAGQNELENYRFVVLQKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8J3</accession>
    <name>Q1D8J3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_2813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552880.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2813"/>
    <dbReference type="EnsemblBacteria" id="ABF91404">
        <property type="protein sequence ID" value="ABF91404"/>
        <property type="gene ID" value="MXAN_2813"/>
    </dbReference>
    <dbReference type="GeneID" id="41360189"/>
    <dbReference type="KEGG" id="mxa:MXAN_2813"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224144_0_0_7"/>
    <dbReference type="OMA" id="FGHAWAG"/>
    <dbReference type="OrthoDB" id="1489229at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14265">
        <property type="entry name" value="UDPK_IM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021206">
        <property type="entry name" value="MprA_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033717">
        <property type="entry name" value="UDPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03867">
        <property type="entry name" value="MprA_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01069">
        <property type="entry name" value="DAGK_PROKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="22997" checksum="A7E45D00AC9A07E2" modified="2006-07-11" version="1">MNAPPRPPSSFPPRHGSGLLASFGHAWAGLIHTVIYQRNMRVHLIAAVLVGLVGSGIPLGLAEKVTLIFCVLLIFFAEILNSALEHLVDLAVQQFDEKARLAKDAAAAGVLVLALGTVVIFAAILVHNWDTVRTSTDAIIRQVALGLPLTACILVLVLPQRRPAWVDVAAFTAGGVLMALQATQTASSVFSALTAGLLFVAGAAAYQRRREQRAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8J6</accession>
    <name>Q1D8J6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2810"/>
    <dbReference type="EnsemblBacteria" id="ABF92983">
        <property type="protein sequence ID" value="ABF92983"/>
        <property type="gene ID" value="MXAN_2810"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2810"/>
    <dbReference type="HOGENOM" id="CLU_2060005_0_0_7"/>
    <dbReference type="OMA" id="SSALWRK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="15358" checksum="FFFB3464B5B43A54" modified="2006-07-11" version="1">MDCASLSRLPPNCPDGRPGGGLMGYVVRTPEGELVYPSLLDVERAYVQGLVDAEDEVREETATTWRKAASIPVLARAKPARSGALQRGQVLRVAAVVLLSALALSLVFRDELRLRGIGIVLALVASSLLFQVTTKAFKRTPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R5</accession>
    <name>Q1D8R5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552808.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2741"/>
    <dbReference type="EnsemblBacteria" id="ABF88982">
        <property type="protein sequence ID" value="ABF88982"/>
        <property type="gene ID" value="MXAN_2741"/>
    </dbReference>
    <dbReference type="GeneID" id="41360119"/>
    <dbReference type="KEGG" id="mxa:MXAN_2741"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127596_1_0_7"/>
    <dbReference type="OMA" id="RYKVCAG"/>
    <dbReference type="OrthoDB" id="1856687at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="21474" checksum="17FBF91F700DEE41" modified="2006-07-11" version="1">MLRVGPFVFILPDCGARPGGHGMHAKRLGIYLNDHLAGSVGGLELAIRTEVENRGNLLGRYLATLVPELKEDQSTLLAVMDALALKRDGLKTRAAWAVEKVSRLKLNGTLVRYSPLSRLLELEGLCAATEGRLSLWRTLARVSVKDARLAVFPFESLVQRGEAQRSVLQRLRAQAADVAFAEEPQPFGTGEPLIAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R7</accession>
    <name>Q1D8R7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552806.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2739"/>
    <dbReference type="EnsemblBacteria" id="ABF87937">
        <property type="protein sequence ID" value="ABF87937"/>
        <property type="gene ID" value="MXAN_2739"/>
    </dbReference>
    <dbReference type="GeneID" id="41360116"/>
    <dbReference type="KEGG" id="mxa:MXAN_2739"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_1_0_7"/>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="29738" checksum="B03EB631FE3BB7BD" modified="2006-07-11" version="1">MIDLHSHTTASDGQYAPTELLARAAAAGVTVLAITDHDTVAGLAEAEVAARAHGVELVPGIEISAFIHGRECHILGHFLRPDDEDIARFADRLRLEREQRMEALLERMRQLGYPVRMEHVRAVAGDAQLGRPHLARVLVDRGWVVDVKEAFDRFLGMRGAAWVERFKLTGEDAIRLIRNAGGTATLAHPGSSRMERLEIRALAQAGLAGLEVLHEDHNPSVRQKYLSLAKELGLVPTAGSDFHGEAISADHRLGTASMPPELFARLKSRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8S0</accession>
    <name>Q1D8S0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552803.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D8S0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2736"/>
    <dbReference type="EnsemblBacteria" id="ABF90400">
        <property type="protein sequence ID" value="ABF90400"/>
        <property type="gene ID" value="MXAN_2736"/>
    </dbReference>
    <dbReference type="GeneID" id="41360113"/>
    <dbReference type="KEGG" id="mxa:MXAN_2736"/>
    <dbReference type="eggNOG" id="ENOG50334ZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183805_0_0_7"/>
    <dbReference type="OMA" id="EEIEFQI"/>
    <dbReference type="OrthoDB" id="2022191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="78" mass="9153" checksum="8719573665DB7AAC" modified="2006-07-11" version="1">MAQKKAKRANRDLEKTYPRKDFVAKLRRLADAIEEGKAFNIQVAGERLRIPADALFNIEHERGDGVDEVEFQLRWQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D973</accession>
    <name>Q1D973_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552651.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2581"/>
    <dbReference type="EnsemblBacteria" id="ABF88019">
        <property type="protein sequence ID" value="ABF88019"/>
        <property type="gene ID" value="MXAN_2581"/>
    </dbReference>
    <dbReference type="GeneID" id="41359959"/>
    <dbReference type="KEGG" id="mxa:MXAN_2581"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184018_0_0_7"/>
    <dbReference type="OMA" id="VMVKSCA"/>
    <dbReference type="OrthoDB" id="1397960at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="24976" checksum="84D7824787973800" modified="2006-07-11" version="1">MDASFSALFEGAKAELSALSVTAILPRMLAAALIGTLLSLRPWRLLMKRALPKVDMIQAQVLLCAAAAVITAVIGDSLAKAFGLVGLGGFVRFRSGLKDPRDAAILFLMIGLGMACGHGSLGLASVGTVFVMVLLFVLDCFNREEAHATAKQRLVLSAQSDDLVGAEATLRRVLGERNVMVKSCALDFDGRRLELEVEEPEPGSLAAALGRTEGAALRGLRWTAVNSRSAREERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9K3</accession>
    <name>Q1D9K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FlhB/HrpN/YscU/SpaS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552524.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2450"/>
    <dbReference type="EnsemblBacteria" id="ABF87691">
        <property type="protein sequence ID" value="ABF87691"/>
        <property type="gene ID" value="MXAN_2450"/>
    </dbReference>
    <dbReference type="GeneID" id="41359834"/>
    <dbReference type="KEGG" id="mxa:MXAN_2450"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_1_2_7"/>
    <dbReference type="OMA" id="DPHHKAK"/>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="359" mass="39973" checksum="14EBEF601FDEFCFF" modified="2006-07-11" version="1">MSDESGEKTEEPSQKKLDDSRKKGQVWKSKDLSGVGVLLVGLAAVKGSWDMLETELTSLFLFSFDHLTNPVDLSVATGQLLFLGLRAVVLVSLPVLAGGAIVGGLMEYLQVGTLFTMDPLIPKMEKLNPIQGMKNLFNKKAIVELLKNLIKISVTAYVVYGVVRDSMPMVAETLRQDTRGIMAIMGELVTRVATRVALLFVLFGVFDVWWQRKSFMKDMMMTKEEVKKEYKQSEGDPHHKAKRKEMHQEIMEGAQMEAVREADVIVTNPDHVAVALKYDREKDGAPRVLARGIDFKAERIKAIAREQDVPTLRNVPLAHALLRVEVGHEVPEELYDAVAEVLNFVYGLKSGQPAPEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9U8</accession>
    <name>Q1D9U8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552430.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91999">
        <property type="protein sequence ID" value="ABF91999"/>
        <property type="gene ID" value="MXAN_2355"/>
    </dbReference>
    <dbReference type="GeneID" id="41359739"/>
    <dbReference type="KEGG" id="mxa:MXAN_2355"/>
    <dbReference type="eggNOG" id="ENOG502ZBQY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070559_0_0_7"/>
    <dbReference type="OMA" id="HRWSASA"/>
    <dbReference type="OrthoDB" id="1339074at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="35594" checksum="F23CDF3BFFD87BCF" modified="2006-07-11" version="1">MEASSPQACPRCQSPRAAGPECPRCGIIYAKAEARAARQREEAPSVAPGEPPPLVDPAWLATPDLRPDVLPPETPAWDGDAEEAAFEHRLRTWAIPVALLVSYVALNGNFSAFAARLITMPFHELGHAMTAWFCGRSAFPTLWKTAIFGRSYVLALMLAAVLGAWAWWGWRRRQWLWVACGASLLALQAVGTLLLSPQTVDMLITFNGDGGMMVLGTVMMLTIYAPAGSYLHKQALRWGFLGLGALSLMDGLLTWWKSKKDFNAIPFGRMEGVGLSDASKLVGMPHNWGEHQLIGRYLTVATVCFAVVAGVYVVQFVRGRARLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W4</accession>
    <name>Q1D9W4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552414.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2339"/>
    <dbReference type="EnsemblBacteria" id="ABF85918">
        <property type="protein sequence ID" value="ABF85918"/>
        <property type="gene ID" value="MXAN_2339"/>
    </dbReference>
    <dbReference type="GeneID" id="41359725"/>
    <dbReference type="KEGG" id="mxa:MXAN_2339"/>
    <dbReference type="eggNOG" id="COG1648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_1_7"/>
    <dbReference type="OMA" id="STQIWKL"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF85918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="23979" checksum="D9A5603D3CBD46A9" modified="2006-07-11" version="1">MKHAMPSHPLDYPVCLRLEGRSVLLVGGGAIAEGRALAVLDAGARLRVIAPEATATLRRLAADGRLEWQPRSYKAGDVRGHHLVLAATDDVAVGRQVATEARDVGLWVNTADEPALCDFTLPSVGRRGPITVAVSSAGRAPALASHLRKTLTAQVTRHHIWLARLSGWLREHLPRGEGRQRLLKQVAVGDIGALLERGERKAAWARLRTELEHSKIPGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA62</accession>
    <name>Q1DA62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552316.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2240"/>
    <dbReference type="EnsemblBacteria" id="ABF89203">
        <property type="protein sequence ID" value="ABF89203"/>
        <property type="gene ID" value="MXAN_2240"/>
    </dbReference>
    <dbReference type="GeneID" id="41359628"/>
    <dbReference type="KEGG" id="mxa:MXAN_2240"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_7"/>
    <dbReference type="OMA" id="IEAGPFH"/>
    <dbReference type="OrthoDB" id="1752728at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="317" mass="32687" checksum="210542B201043D99" modified="2006-07-11" version="1">MKAAAIDRFGGPEVLGVKTVAVPVVGAGEVLIQVETAGVGSWDAAEREGEMELLKPRKSSFPYVLGTDGAGTIMAVGEGVTSRKVGDRVYGSGFLNDKGGFFAEYAVVKADDTALVPKGLSAEQAGVLAADGITALQGVQDALNVRQGMSLLVYGASGGVGHLAVQLARRLGARVLAVASGSDGVELVKRLGAEKAVDGRGGDDVAKAIRDFAPDGLDAALVLAGGEGRAPALQAVKKGGHIAYPNGVEPEPRAPEGVKLTAYNGESNADVLARLNRLIEAGPFHVEVFQVYRLDDAGRALEAARKHHLGKLALRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA80</accession>
    <name>Q1DA80_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2222"/>
    <dbReference type="EnsemblBacteria" id="ABF87492">
        <property type="protein sequence ID" value="ABF87492"/>
        <property type="gene ID" value="MXAN_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2222"/>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074086_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="35427" checksum="AA6569FAA3E8748F" modified="2006-07-11" version="1">MVRWAPVVNRVSALLARAKHGGSRGGTVPGHSFGDSRRPSCRRLTMTGRCGFPATGTGLAGSVEMCLSSLVLTWVLSLQASAAPSSPKPVTVMTYNVLYSAPEEDVQKSLDVIEKEAPDILCLRELTPRFARAFRKRLGKQFPHVRLVPRKGTWGVGIASRYRLLRTEHFPQTPHRMPALEADIRLGEHWVKVACVHLMAPGARHQRADDLLTSMEKNAVLRHRQAEALVRRYARWRGPVLVLGDMNEGRSGKAMKAFASAGFQHACDGPDAACGATWPGTASVLPSVVEIDHVLGRELRLSGAKVLRAGGSDHDAVRATLDFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAH7</accession>
    <name>Q1DAH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase orfB, IS3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2122"/>
    <dbReference type="EnsemblBacteria" id="ABF92987">
        <property type="protein sequence ID" value="ABF92987"/>
        <property type="gene ID" value="MXAN_2122"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2122"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_31_0_7"/>
    <dbReference type="OMA" id="RMTAQLN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="109"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="33027" checksum="B8E5BFC480BA1115" modified="2006-07-11" version="1">MVSAPVRRRQVRYAMGKGVSQRRACALLQVAGSSLGYASRKEAKDAALVAQLRDIARARPRFGYRRAWALLRREGPAVNVKRVHRLWRKEGLALSRRRPRKRLRLGQQRQPKPEGVNSVWAWDFVHDRCANGQKLKCLTVVDEHSRECLAIDVAGRISARRVIEVLSRLVAVHGPPKYLRSDNGPEFIAKALRRWLEANGIQTAYIAPGKPWQNGTNESFNGRFRDECLSAEWFSTRREAVVLIEAWRRDYNEKRPHSSLGYKTPAEVGARRAHAGPVASSLEHGISSAAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI9</accession>
    <name>Q1DAI9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552189.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2107"/>
    <dbReference type="EnsemblBacteria" id="ABF88560">
        <property type="protein sequence ID" value="ABF88560"/>
        <property type="gene ID" value="MXAN_2107"/>
    </dbReference>
    <dbReference type="GeneID" id="41359512"/>
    <dbReference type="KEGG" id="mxa:MXAN_2107"/>
    <dbReference type="eggNOG" id="ENOG502Z7NR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663614_0_0_7"/>
    <dbReference type="OMA" id="ESPVECW"/>
    <dbReference type="OrthoDB" id="2012490at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188080" evidence="2">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="414" mass="43741" checksum="70C2D47E4BEB2373" modified="2006-07-11" version="1">MPLPRLTLLSAVLLTGCATSPAANRTESKPAPAASAPAEPRTVREALAREITAPLPHKPVEAEGVLFRGKVLAAGTPELMKRPNGVTILTLPIGTSEPVTCLFYTSSIDAGAAVRSLLESLLDDVTVERVRATDVKSFTGSPAMYLEGDYSRGAAPAVQVGRIKVMVHADPVLPKTCFHNELGYTKTFLDVTESIATGLTSTAREQPVAPYYSDVQVMRLGDVPLGFQYTALFGAKAGGSILEVSTTMVRPGAPAQLQFQDTNITEQADISGVLVAKSYSKRVNDTVAANVRLRREQNGSYGVSGQVAAKEVQAQFGGELIGEVGLAARLREGLLKGQGDALEALLWVPPADASAPTKMVIRPREEAGARAATMELGPMSVKVELDAHGFPQRTEIPSGSATVVQERLSQTGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB86</accession>
    <name>Q1DB86_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551943.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1841"/>
    <dbReference type="EnsemblBacteria" id="ABF88216">
        <property type="protein sequence ID" value="ABF88216"/>
        <property type="gene ID" value="MXAN_1841"/>
    </dbReference>
    <dbReference type="GeneID" id="41359258"/>
    <dbReference type="KEGG" id="mxa:MXAN_1841"/>
    <dbReference type="eggNOG" id="ENOG5032YFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011688_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="31870" checksum="FFCB6EFBBA603F25" modified="2006-07-11" version="1">MAQLNRSASPMIRQTKHIDSSNSKPHWWEVGGKICFYDARGEVAQLHIQQLQEEAVRIVRQHPSGIRLMPLARGVHNLHPEAPFASIPPALHSMGRTTFTNAVSRPERGLYVPTRKSVPPVTIPADQEEEFLLPLAAFLEGDVEELTAAVPLGSQGLGDPWGLPDIVGVYRRCAGDSFSWTPEILAVEVRGTTEDLLSAYGQAAAHQLFATKTYLALPHTLSLRDRRELVARCQLHGLGLILFGPGPRDEYTVLIPARRCPPAPDEALRFSERLRAHDEEKFRTLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE8</accession>
    <name>Q1DBE8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551884.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1775"/>
    <dbReference type="EnsemblBacteria" id="ABF88091">
        <property type="protein sequence ID" value="ABF88091"/>
        <property type="gene ID" value="MXAN_1775"/>
    </dbReference>
    <dbReference type="GeneID" id="41359200"/>
    <dbReference type="KEGG" id="mxa:MXAN_1775"/>
    <dbReference type="eggNOG" id="ENOG5031B6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072761_0_0_7"/>
    <dbReference type="OMA" id="YFAWVIP"/>
    <dbReference type="OrthoDB" id="1884964at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="25262" checksum="041D916A1FA50325" modified="2006-07-11" version="1">MLPAPHTLRRWLLAVASLLTLLGAGVEVAYYALDARGLEPFVAFLSLSYERNLPTWYASALLLSCALVLACIGHMAGQGREQGWRHWRALAGAFAYISLDESVGLHEHLGGQLSLGGVLFFTWVVPGAVLVLLGGLAFLPFLAGLRPRRRRQFILAGVLYVGGALVMELPLGWWAEQHGNDNLVYALIDHVEEALELIGASLFLAALAEELGERVVLTVRKEEPHGPGPAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE9</accession>
    <name>Q1DBE9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551883.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1774"/>
    <dbReference type="EnsemblBacteria" id="ABF87663">
        <property type="protein sequence ID" value="ABF87663"/>
        <property type="gene ID" value="MXAN_1774"/>
    </dbReference>
    <dbReference type="GeneID" id="41359199"/>
    <dbReference type="KEGG" id="mxa:MXAN_1774"/>
    <dbReference type="eggNOG" id="ENOG5032ZYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813219_0_0_7"/>
    <dbReference type="OMA" id="CSIYTWG"/>
    <dbReference type="OrthoDB" id="1115456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="360" mass="40079" checksum="D748B3B478A869A4" modified="2006-07-11" version="1">MGLAQPLPAETQRPAESVRVSPPSSSRAPYIAGPLFDWAFFLLPPLLALGLGIVISGTPFSDTPVQRLGQEKTWAGLMVGSLIHAHLVAVFFRSHGNPAIFRLYPLRFILVPVLAWAAIRGSAVVAAGATVLATFWDVWHSGLQTFGLARIYDRNQGNPPEVGRQLDFWLNHLLYAGPILAGATMLDHFNSFESFDGVGMPWLASVPARMTATHRAWTLGVVAVGGMFLLFYIGATVRLLRQGHRPSFHKAFLLVTTGACSIYTWGFNSWGEAFFIMNLLHAIQYLALVWAMEGERLRERLRLKWRWLALALFLGTVLTYGVWAELLDASAESLWALTLVVSLMHFWYDGFIWSVARRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH5</accession>
    <name>Q1DBH5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551857.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1748"/>
    <dbReference type="EnsemblBacteria" id="ABF92308">
        <property type="protein sequence ID" value="ABF92308"/>
        <property type="gene ID" value="MXAN_1748"/>
    </dbReference>
    <dbReference type="GeneID" id="41359180"/>
    <dbReference type="KEGG" id="mxa:MXAN_1748"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_32_1_7"/>
    <dbReference type="OMA" id="VHFLYHR"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032962">
        <property type="entry name" value="HPA2/HPA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF42">
        <property type="entry name" value="PTHR10545:SF42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="18212" checksum="92C531C50977D42E" modified="2006-07-11" version="1">MSEKNHMIVRPVERGDFEQWLPYWKSYQEFYKVTLPEEVTQATWERFFDDREPMHSAVAVDGERIVGFVNYLFHRSTWAQNDFCYLEDLFVAPETRGRHAGKKLIEFVQERARAKACGRLYWHTQETNHTAQRLYDWIGEKPGVIEYRMSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH7</accession>
    <name>Q1DBH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551855.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1746"/>
    <dbReference type="EnsemblBacteria" id="ABF88431">
        <property type="protein sequence ID" value="ABF88431"/>
        <property type="gene ID" value="MXAN_1746"/>
    </dbReference>
    <dbReference type="GeneID" id="41359178"/>
    <dbReference type="KEGG" id="mxa:MXAN_1746"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_7"/>
    <dbReference type="OMA" id="RIGFMVM"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="498" mass="55099" checksum="3C2770F19B23E51A" modified="2006-07-11" version="1">MDSPRIKNDEGPVRRPWRFDFTLERDTSVSQQTQLTRALIHEIQRGRLPPGSMLPGSRTLADQLGVNRKVVVAAVDELVAQGWLETRPASGTRVAASLPRSAFADVELPTQRKSALLRRDTSLVSITDGLPDPRLAPQAELARAYARALRSLSRTAAGYGDAAGAPSLREVISSFVNQARGLSTTIDEIFLARGSQGALSLYALAMLERGDVVAVEVPGYAPAWRAFEFAGAKISHIPIDGEGLRTDVLEKTARRLSGKLKAVYVTPHHQYPTSVSMTPERRIKLLQLAEHFDFTIVEDDYDYEYHFEGEPLLPLHATGGSRRVVYIASLSKLLAPTVRLGYLVASEGCIRKLKETRELLERQGDVVLEHAIAELFEDGTLQRHARRARREYKARRDHLLSRLRATPALDECFDYSVPAGGLALWLTLRKGSIDSLVARAREEHLLMAPGSTYLPKGRLDAVRLGFAAHTPDELSRICDTLARCIPSRPGLRPNLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI5</accession>
    <name>Q1DBI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1738"/>
    <dbReference type="EnsemblBacteria" id="ABF92424">
        <property type="protein sequence ID" value="ABF92424"/>
        <property type="gene ID" value="MXAN_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1738"/>
    <dbReference type="HOGENOM" id="CLU_3101220_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="51" mass="5666" checksum="E43F8A482931585E" modified="2006-07-11" version="1">MASVNNEASTATCMRAVESHSEEAPAPPMNGRGQLHWVAGFTRRPRQDYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ9</accession>
    <name>Q1DBQ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1662"/>
    <dbReference type="EnsemblBacteria" id="ABF88519">
        <property type="protein sequence ID" value="ABF88519"/>
        <property type="gene ID" value="MXAN_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1662"/>
    <dbReference type="HOGENOM" id="CLU_3218987_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4690" checksum="BD4FE4B57AF73678" modified="2006-07-11" version="1">MSNVYLNFEASRFFEALALVLVLTLTHGAGACAIACLFFHGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR4</accession>
    <name>Q1DBR4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551768.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92273">
        <property type="protein sequence ID" value="ABF92273"/>
        <property type="gene ID" value="MXAN_1657"/>
    </dbReference>
    <dbReference type="GeneID" id="41359098"/>
    <dbReference type="KEGG" id="mxa:MXAN_1657"/>
    <dbReference type="HOGENOM" id="CLU_2106326_0_0_7"/>
    <dbReference type="OMA" id="NALMACC"/>
    <dbReference type="OrthoDB" id="1953894at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="115" mass="12667" checksum="3A9FDC6A92FDA3E2" modified="2006-07-11" version="1">MQGHVRAETMRNQMKSTLPLWMGALLAVGCGGPLPEESQEPQESIAIPEQYLEQADPSTEDGTVSALKACCFIRCSDKVWRGPYPNVVYGNCRNHGKYQCAKRGLGYAGADWKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBS9</accession>
    <name>Q1DBS9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1642"/>
    <dbReference type="EnsemblBacteria" id="ABF89992">
        <property type="protein sequence ID" value="ABF89992"/>
        <property type="gene ID" value="MXAN_1642"/>
    </dbReference>
    <dbReference type="GeneID" id="41359084"/>
    <dbReference type="KEGG" id="mxa:MXAN_1642"/>
    <dbReference type="HOGENOM" id="CLU_111102_0_0_7"/>
    <dbReference type="OMA" id="MKASSTM"/>
    <dbReference type="OrthoDB" id="1540401at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188116" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="181" mass="19057" checksum="D5DE8EBBE96972F5" modified="2006-07-11" version="1">MKKTMLSTCVCAALALTACGGGSDRLDSVQGEPPAPSGPVQTEDGQRFELRLRGSAAEGYDKLELPIGAVRVTANGAPLKVELVQDSADVARADHAHLVAYFYVPEGADRVRVTLQLEGLGGYARAEGSGFVDASVAPVTFEAPVHELALRGRAVVQLDVARSIMDMGSHRLLLPNGVVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBT8</accession>
    <name>Q1DBT8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551744.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1633"/>
    <dbReference type="EnsemblBacteria" id="ABF90552">
        <property type="protein sequence ID" value="ABF90552"/>
        <property type="gene ID" value="MXAN_1633"/>
    </dbReference>
    <dbReference type="GeneID" id="41359077"/>
    <dbReference type="KEGG" id="mxa:MXAN_1633"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_0_7"/>
    <dbReference type="OMA" id="IGYWIDT"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="22937" checksum="E0718828939209D9" modified="2006-07-11" version="1">MTPTPFGPAYTLQTARTLLRCWSPADAARALRAIDASLDHLRPWLDWARHYPISVEQQAAVLRRFRGSFDLGQDFTYAVFDRGGTEVLGGCGLHPRVGEGGREIGYWIAAQHAGQGLATEVAAALVRVAFELDGLRRVEIHCDPLNVPSAAVARKLGFTHEGTLRQRLQAADGSWRDVMLWTLLAEDYRASPAAASDLEAFDVLGQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC01</accession>
    <name>Q1DC01_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551681.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1570"/>
    <dbReference type="EnsemblBacteria" id="ABF90634">
        <property type="protein sequence ID" value="ABF90634"/>
        <property type="gene ID" value="MXAN_1570"/>
    </dbReference>
    <dbReference type="GeneID" id="41359015"/>
    <dbReference type="KEGG" id="mxa:MXAN_1570"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_7"/>
    <dbReference type="OMA" id="SDCEHPG"/>
    <dbReference type="OrthoDB" id="1474443at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="45"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="378" mass="41304" checksum="292FAA0B2BFE512A" modified="2006-07-11" version="1">MTRSLESYRDLFPVLKEQLYLNHAGVAPTSLRAAEAVRGWMEDIVHHGIKHERGWEAHCERVRGLAARLINAEPGEIAFVRNTSHGLGLVAEGLDWTPGDEVVVASSLEYPSNVYPWLHLKDRGVTVREIQTPEGGVTPEAVAAALTPSTRLVAVSSVQFATGYRTDLDAVGALCERAGVLFCVDGIQSVGCIPVDVKKSRIHFLSADSHKWMLGIAGIGFLYVAKDVLPRLRPVLVGWRSTTDAWNFNRSHFELRPDAGKLEEGSAAYTGIYALGAALELLHEVGVDAISARIRELLGQLETGLRGLGCDVGPAPEHRAGILTFLPPEGEARALGAWLAGREVALSVRRGRVRLSPHFYNLPEEMDRLVELVRTHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCR0</accession>
    <name>Q1DCR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1306"/>
    <dbReference type="EnsemblBacteria" id="ABF86149">
        <property type="protein sequence ID" value="ABF86149"/>
        <property type="gene ID" value="MXAN_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1306"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063022_1_0_7"/>
    <dbReference type="OMA" id="WEPAAVI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="406" mass="41701" checksum="93FC2417964D1CBA" modified="2006-07-11" version="1">MDTDPARGRGRREAPAASAFCPVAGGRLGRVGWGMKVFVEALGMASCLGPVIPACAAFRANLLRSSPSPDVDVAHAGDEAPRPVTICALPVATFGFSGVGRLVALACEVLKDVGTRVDLRGLGPETGVYLALPDPWERGLDLGEPDATEALRVEALGRRVLEASLRNMGLEWPGPRRFFGGGHVAFARALHAAQAALQNGGLRSCLVMGVDCLVEEPTLHALADGRRLKTPEQPVGLTPGEAGAALLLTTEGPAQRSTGAPQVMLHAVRLGEEPHPRGSDKPSDGRALAACAEAVLAAAGALRARPLLVSDHNGEEGKAREWGMVLLHLRALDASLGGLPAWYPSIGFGDVGAAMGAVSACVAVRGLQRGDAPSSVSLVFASADDSGRGAVLIGTTAAHPSRGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT8</accession>
    <name>Q1DCT8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551395.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92423">
        <property type="protein sequence ID" value="ABF92423"/>
        <property type="gene ID" value="MXAN_1278"/>
    </dbReference>
    <dbReference type="GeneID" id="41358724"/>
    <dbReference type="KEGG" id="mxa:MXAN_1278"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106219_0_0_7"/>
    <dbReference type="OMA" id="RRIIVYL"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188492" evidence="1">
        <location>
            <begin position="34"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29619" checksum="C0BC1FF50450835B" modified="2006-07-11" version="1">MHPTDVRCRSPRRNLAMWMASSLLLAACGGAEAEALADAESPGVASQSLVEPSSESADRRIIVYQTTSLQLIRMDNQGDSHLVAERTGAPEVSLDGSRVAYVKLPDGYREGDVVRSSELYVLNANSGRSVRVTQGFDDSEPVWTPDGRNVLFQSTRRSGVPSLWLVKENGKDLKQLTNAGTSQFSSAYIPNPALGGTVEWDADRRIIVYTTTSLRPGEDGEVRVITFDRNYDVATAYSLGTGFGPVWTERGTVVYSRNEGERVVSVEVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDA8</accession>
    <name>Q1DDA8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551225.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1105"/>
    <dbReference type="EnsemblBacteria" id="ABF90657">
        <property type="protein sequence ID" value="ABF90657"/>
        <property type="gene ID" value="MXAN_1105"/>
    </dbReference>
    <dbReference type="GeneID" id="41358557"/>
    <dbReference type="KEGG" id="mxa:MXAN_1105"/>
    <dbReference type="eggNOG" id="COG1534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_2_1_7"/>
    <dbReference type="OMA" id="FQVGKNG"/>
    <dbReference type="OrthoDB" id="2034603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10586" checksum="8B728528FB2057B3" modified="2006-07-11" version="1">MPLTGKQRRHLRALGHHLEPVVIVGQAGVTEGVIAAIEQALQDHELIKVKINEGPETRQEAAARIAEGAQAELAQLLGRTALVFKKRKKDSKFEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDD7</accession>
    <name>Q1DDD7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">SelB translation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">selB</name>
        <name evidence="7" type="ORF">MXAN_1076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551196.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1076"/>
    <dbReference type="EnsemblBacteria" id="ABF90845">
        <property type="protein sequence ID" value="ABF90845"/>
        <property type="gene ID" value="MXAN_1076"/>
    </dbReference>
    <dbReference type="GeneID" id="41358527"/>
    <dbReference type="KEGG" id="mxa:MXAN_1076"/>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023030_3_0_7"/>
    <dbReference type="OMA" id="WVDRAFT"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="638" mass="67779" checksum="E587190F4917BAC4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ2</accession>
    <name>Q1DEZ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550644.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0512"/>
    <dbReference type="EnsemblBacteria" id="ABF89649">
        <property type="protein sequence ID" value="ABF89649"/>
        <property type="gene ID" value="MXAN_0512"/>
    </dbReference>
    <dbReference type="GeneID" id="41357997"/>
    <dbReference type="KEGG" id="mxa:MXAN_0512"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093394_0_0_7"/>
    <dbReference type="OMA" id="VHMYHEI"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="2">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27210" checksum="78B1A2C0352DDECE" modified="2006-07-11" version="1">MSQHGGAILEGAPVAPPPPKRSPGMTFFRAHATPRRLARLLLCLVTAATGGCRSEGGEEKRPEPSRTPTEAPAAEQPADLHGLGGVEGVQASYDQSRQPARFIAALGITPGQRIADVGAGLGYFTQRLSEAVGPAGQVVATDINDEALKRLRARMSERKNVVVRKVEPDEPGLEPGAYDLILLSEVDHFLSDRVAYLTRLRLALTPNGRIAVTHLRAMRPPLVAAAQQAGYSIVSEYDGLPDHYLLFLQPASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFA1</accession>
    <name>Q1DFA1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550536.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0401"/>
    <dbReference type="EnsemblBacteria" id="ABF92586">
        <property type="protein sequence ID" value="ABF92586"/>
        <property type="gene ID" value="MXAN_0401"/>
    </dbReference>
    <dbReference type="GeneID" id="41357895"/>
    <dbReference type="KEGG" id="mxa:MXAN_0401"/>
    <dbReference type="HOGENOM" id="CLU_1883512_0_0_7"/>
    <dbReference type="OMA" id="YFALQWI"/>
    <dbReference type="OrthoDB" id="1962651at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="13673" checksum="A62A45B7ED7604FB" modified="2006-07-11" version="1">MTARGGGSGTDSFKSHAALAGGVAVVGLALAALMPQVVEDRVSAVWGVGLAAVTGAVALVLKRRAVRQDLNAALKVVGIIFGLRAVGVLAGLLGVVSRGMAAVPFIAGFFGVYFALQWIEVSYVMAASKESAGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT3</accession>
    <name>Q1DFT3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0208"/>
    <dbReference type="EnsemblBacteria" id="ABF89553">
        <property type="protein sequence ID" value="ABF89553"/>
        <property type="gene ID" value="MXAN_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0208"/>
    <dbReference type="HOGENOM" id="CLU_893788_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="33866" checksum="71074C0F88BC0A48" modified="2006-07-11" version="1">MSSDCLPLSPCRSATRVARCDVHCTRAQSARSGTARKTRDLRLSVERHEGCLSRLLDASPGVHPCNWRRSPHEVRAALLTWRWRDDGLESRKLVPLLPTQALPPGVPPAGHLQRSEGQPARQRRVAVCGRQTVRVPGLGPPQCPEPRGADSPPDAAVVVTGDASHPSVSGVTGQPVPPGFRERRRSLKSRPFRSGPGLAATGTGDALVSGSRLPPAPTARPRRWTPARLKKLKPRPGPTLRARHPLKGWAPSDNMIRAEHGLPLHQDSSGMRPGNNRSLRMFEQGPDNRNFFPRMSGQPPPIGKMLNDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT8</accession>
    <name>Q1DFT8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550349.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0203"/>
    <dbReference type="EnsemblBacteria" id="ABF88408">
        <property type="protein sequence ID" value="ABF88408"/>
        <property type="gene ID" value="MXAN_0203"/>
    </dbReference>
    <dbReference type="GeneID" id="41357706"/>
    <dbReference type="KEGG" id="mxa:MXAN_0203"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_7"/>
    <dbReference type="OMA" id="CYRMTGV"/>
    <dbReference type="OrthoDB" id="1335404at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="35132" checksum="5671FAFA9A1933A0" modified="2006-07-11" version="1">MDRSAREGLAQAVREHERFLWGLCYRMTGVSADAEDLVQETFVRALASPPARTEALRPWLTRVAVNLARDTLRRRKREGYVGPWLPSPLDTGEEELPPPGVEARLPGGGSTEGRYALLESVSFAFLLALEVLSPKQRAVLLLRDVFDYSVREVAEALNLRESNVKVVHHRARAAMAAYDRARCLPTREFQARARAALEGFLGALLTGDVAAAEALLASDVCALSDGGGQYRAARVPVLGQSRVLLLYRRLMEMRGAPSAVELRMLNGLPAVVAVFPPPQRDPQAGTQMVVRVELGADGRITQVHSILTDRKLAGLRMPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG94</accession>
    <name>Q1DG94_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0046"/>
    <dbReference type="EnsemblBacteria" id="ABF88597">
        <property type="protein sequence ID" value="ABF88597"/>
        <property type="gene ID" value="MXAN_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0046"/>
    <dbReference type="HOGENOM" id="CLU_120443_0_0_7"/>
    <dbReference type="OMA" id="KYESINT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23991" checksum="7F24342683433D14" modified="2006-07-11" version="1">MGRRGTLRSFRAQGDRYPMKYFVFKVQGIDAGFIDEYPRGSPADWQFDKGISLIKQFPVGGEVSFSKNYPDDRTVYDFQPNLMSDLLVSGRARKLIESLEVTNAEWLPVVVKNHQGAVVGPDYAFLNLQGAEDAIDMERSVYRMNAIAKDQIGRVKKLALKYDAISPQAKLFRCTMERRLILIREDVHAAFVQAGLTGFKVYVAEGWNGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGC4</accession>
    <name>Q1DGC4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase, PHB depolymerase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550165.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0016"/>
    <dbReference type="EnsemblBacteria" id="ABF86069">
        <property type="protein sequence ID" value="ABF86069"/>
        <property type="gene ID" value="MXAN_0016"/>
    </dbReference>
    <dbReference type="GeneID" id="41357523"/>
    <dbReference type="KEGG" id="mxa:MXAN_0016"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_0_0_7"/>
    <dbReference type="OMA" id="PDAMNKA"/>
    <dbReference type="OrthoDB" id="520196at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="65690" checksum="9E75C708A74376E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O30386</accession>
    <name>O30386_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PilI</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative efflux ABC transporter, permease protein PilI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pilI</name>
        <name evidence="8" type="ORF">MXAN_5780</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="1249" last="1261">
            <title>The pilH gene encodes an ABC transporter homologue required for type IV pilus biogenesis and social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Wu J."/>
                <person name="Cheng Y.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9767592"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01013.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="24" last="33">
            <title>The Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pilus biogenesis, social motility, and development.</title>
            <authorList>
                <person name="Wall D."/>
                <person name="Kolenbrander P.E."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9864308"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>New pil genes required for pilus assembly, S-motility, and Tgl stimulation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK 1622</strain>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="DQ242507">
        <property type="protein sequence ID" value="AAC36156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555731.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5780"/>
    <dbReference type="TCDB" id="3.A.1.132.12">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90122">
        <property type="protein sequence ID" value="ABF90122"/>
        <property type="gene ID" value="MXAN_5780"/>
    </dbReference>
    <dbReference type="GeneID" id="41363023"/>
    <dbReference type="KEGG" id="mxa:MXAN_5780"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070325_0_1_7"/>
    <dbReference type="OMA" id="NGFREAR"/>
    <dbReference type="OrthoDB" id="1983084at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC36156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="28048" checksum="7A789F264E3A2E99" modified="1998-01-01" version="1">MGAFAAMAWNGFREARRNRVTVLVAAFALLLLLATTLVTEVTVSTFDRVVTDFGLGVMSLLLVFLSVYLSSGLISREIERRTIFLMVSKPLSRTRFLLARLAGNMLTLGVLLVAMTLLFWVQLALHRSPITQPQLAALGGLYLELFVLTSAGFLMSTFASQLVSALVTTGLYFAGHLCSDIYNLGAASKVELIQWVSKATYYALPNLERLNFRPRATYGIEVTAVELGSATLYALGWGALFCVLAAIVFERRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU1</accession>
    <name>Q1CVU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557287.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7375"/>
    <dbReference type="EnsemblBacteria" id="ABF92706">
        <property type="protein sequence ID" value="ABF92706"/>
        <property type="gene ID" value="MXAN_7375"/>
    </dbReference>
    <dbReference type="GeneID" id="41364535"/>
    <dbReference type="KEGG" id="mxa:MXAN_7375"/>
    <dbReference type="eggNOG" id="ENOG5033H8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097823_0_0_7"/>
    <dbReference type="OMA" id="APRAHIR"/>
    <dbReference type="OrthoDB" id="1006710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="25992" checksum="EA077E70E8D348AA" modified="2006-07-11" version="1">MAEIRELPRVSVNKLGEYLVATPARRKRIIHDQKHPPEQQYLRYPEASHAITDFLCRGMDLSILREHQRRFACSVPQSEFEAQRLQLCSEALERFADLVPWLDLEETLISAVGAEPPVLEVAGVTISVRPEVVLQRMDRHGNARVGLMKLYFSKHQPLDERSGQYIGTLLQRFTEQHLCPLGPCDHRLIQVVDVFAGTVFTAPRAHIRRLSDVVLACEEIAERWSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU8</accession>
    <name>Q1CVU8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557280.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7368"/>
    <dbReference type="EnsemblBacteria" id="ABF86425">
        <property type="protein sequence ID" value="ABF86425"/>
        <property type="gene ID" value="MXAN_7368"/>
    </dbReference>
    <dbReference type="GeneID" id="41364528"/>
    <dbReference type="KEGG" id="mxa:MXAN_7368"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="RWIEMSA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="243"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="313"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="543" mass="60519" checksum="4A472526C5B2C602" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVX8</accession>
    <name>Q1CVX8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557251.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7332"/>
    <dbReference type="EnsemblBacteria" id="ABF88973">
        <property type="protein sequence ID" value="ABF88973"/>
        <property type="gene ID" value="MXAN_7332"/>
    </dbReference>
    <dbReference type="GeneID" id="41364495"/>
    <dbReference type="KEGG" id="mxa:MXAN_7332"/>
    <dbReference type="eggNOG" id="ENOG5030BGD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936585_0_0_7"/>
    <dbReference type="OMA" id="YVVTWVE"/>
    <dbReference type="OrthoDB" id="1099012at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188105" evidence="1">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="26723" checksum="D6C7CE03D0BEE807" modified="2006-07-11" version="1">MNRRHILTGALALAASATVLSGCGSEAERRTFPVEVTSTPMTGANERGWTVTVESAHLSVGPVRFFEGRALTARRFDWYTLIGGTAYAHPGHYSPGDALAEMLTTHTVDLLTGATLGDASAVTGEYGSMELTLTAPTQATDAQGVLSGQAMRVRGTARNAEGVERRFDALTSLPKPIQGVRFEKSLGMEAGRVRIAVKLGTWLGRIDFATATDLDADGVYTFPADSQAQNALVRGVEDTTAYVVTWVEGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ4</accession>
    <name>Q1CVZ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557235.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7316"/>
    <dbReference type="EnsemblBacteria" id="ABF90337">
        <property type="protein sequence ID" value="ABF90337"/>
        <property type="gene ID" value="MXAN_7316"/>
    </dbReference>
    <dbReference type="GeneID" id="41364479"/>
    <dbReference type="KEGG" id="mxa:MXAN_7316"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_7"/>
    <dbReference type="OMA" id="ARQYLSM"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="216" mass="23226" checksum="1973DDDA61AE4799" modified="2006-07-11" version="1">MSTSPRSRLRATAARLPPTAAAPPEGTRRRILETALQLFASRGYHDTSIRDLASALELRPSALYAHFAAKDHVLAELVRIGHEAHFEALETAFQGAKPTPADQVRALVHAHTRVHAEHPQLALVVNEEFYALSLELAAPAQALRDKANAMLIDAIQRGMAQGQFSPLHPQITAAAIVGMGSRIPHWFEPGGPIAVETLAKTHAELALRMLGSVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB4</accession>
    <name>Q1CWB4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEGA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557115.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7196"/>
    <dbReference type="EnsemblBacteria" id="ABF88371">
        <property type="protein sequence ID" value="ABF88371"/>
        <property type="gene ID" value="MXAN_7196"/>
    </dbReference>
    <dbReference type="GeneID" id="41364368"/>
    <dbReference type="KEGG" id="mxa:MXAN_7196"/>
    <dbReference type="eggNOG" id="ENOG5030TCP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515637_0_0_7"/>
    <dbReference type="OMA" id="PKWFAAT"/>
    <dbReference type="OrthoDB" id="413339at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="3">
        <location>
            <begin position="204"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="528" mass="55992" checksum="E776DD247210058D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF0</accession>
    <name>Q1CWF0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">MXAN_7160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557079.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7160"/>
    <dbReference type="EnsemblBacteria" id="ABF93060">
        <property type="protein sequence ID" value="ABF93060"/>
        <property type="gene ID" value="MXAN_7160"/>
    </dbReference>
    <dbReference type="GeneID" id="41364334"/>
    <dbReference type="KEGG" id="mxa:MXAN_7160"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_7"/>
    <dbReference type="OMA" id="HMTHFSD"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="280"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF93060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="409" mass="44019" checksum="32819678F000E814" modified="2006-07-11" version="1">MAASVVEVNVESIGSGPGDAVHSSWLELSASALRHNVAVFRALEGQGAPRALGVVLKGNAYGHGLAQVLPVVHGEVDLLYVIAPQDALKVREYERAQGLGPRQVLVLGAVAPDEAVVLAREGVDAVVADRGWADAAAVLRAAKLERPLRVHVHLDTGLGREGFTLEGLPTESRFLSESRDVLEVVGVLSHFANTEDVTEQGYALAQVDAFEKGLAFLSEQLAPARPLQRHIAASAATLVLPRARYEALRVGISLYGLWPSPETRLSARLVLGEVPVLKPVLSWRCRSQVVKWLSAGSYVGYGCTYRCPEPTRIAVLPVGYYDGYPRLVSGKAHVLVNGRRCPVLGRVMMNHLIVDVTRATSDERPVTATLMGRDGEESVPAESLAGWAQTIHYELVTRLGAHLKRTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF6</accession>
    <name>Q1CWF6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557073.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7154"/>
    <dbReference type="ESTHER" id="myxxd-q1cwf6">
        <property type="family name" value="DLH-S"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.B04"/>
    <dbReference type="EnsemblBacteria" id="ABF92432">
        <property type="protein sequence ID" value="ABF92432"/>
        <property type="gene ID" value="MXAN_7154"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7154"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_7"/>
    <dbReference type="OMA" id="LFEEPGK"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="93"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="230" mass="24260" checksum="E1F66961FE7748DA" modified="2006-07-11" version="1">MWQEGNTDPDIREVQVQVGDVVLGGSLGIPDGARGLVIFAHGSGSSRFSPRNRAVARALRAQGLATLLFDLLSEVEEVKDARTGELRFDIPFLARRLAAVTEWAQRQPALAVLRMGYFGSSTGAAAALVAAALHPDLIHAVVSRGGRPDLAGPVLPRVQAPTLLLVGGQDVGVLELNEASLARMEGLKGIHIIPGATHLFEEPGALEQVARQAAAWFLRFLGGVGAEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ9</accession>
    <name>Q1CWJ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557030.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CWJ9"/>
    <dbReference type="STRING" id="246197.MXAN_7111"/>
    <dbReference type="EnsemblBacteria" id="ABF92969">
        <property type="protein sequence ID" value="ABF92969"/>
        <property type="gene ID" value="MXAN_7111"/>
    </dbReference>
    <dbReference type="GeneID" id="41364285"/>
    <dbReference type="KEGG" id="mxa:MXAN_7111"/>
    <dbReference type="eggNOG" id="ENOG502Z7ZS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_1_0_7"/>
    <dbReference type="OMA" id="RRLNWTM"/>
    <dbReference type="OrthoDB" id="947955at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="DUF3445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="DUF3445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="313" mass="34805" checksum="3170A8AE0AE7EA3C" modified="2006-07-11" version="1">MLPYFPFEQDVFSMSLGVRALRPEETLIEVDAPRYADEVALKAALLTAGHAERFQGGPGTEELQWETLTVLLPAMARQSPEHFSLEVDGTRWCWHNRLLGTRTDFTPGDAASLPLAPLDWFGRQVQEDLLLLAGTHEGFPLVAGQLCFPSGWCLGDKLGRSLLAVHEPVPQFNAKLGPSTLKLMEGLKPGRPVTRCNWAISVTERLDLEPRTLPEWRHLFDGITPDNAGERCFLRLERQTLTRLPRTRAILFTIHTYVAPVASEVEAPGRRQRLARVLRTVPADTAAYKRITPVLAPLLGYLEAGEADAGWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXG2</accession>
    <name>Q1CXG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556719.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6794"/>
    <dbReference type="EnsemblBacteria" id="ABF90531">
        <property type="protein sequence ID" value="ABF90531"/>
        <property type="gene ID" value="MXAN_6794"/>
    </dbReference>
    <dbReference type="GeneID" id="41363984"/>
    <dbReference type="KEGG" id="mxa:MXAN_6794"/>
    <dbReference type="HOGENOM" id="CLU_902627_0_0_7"/>
    <dbReference type="OrthoDB" id="1602858at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="32992" checksum="4CCCF8FF9260D2E0" modified="2006-07-11" version="1">MSGITDAEFLQDAFIQEGVSPAPGVVIAACTVGDDEDAPKNRVGVRHDGEWLEFSLSNEAILSVDATPGGEAYVLGENGTVVRFDWKTPKTRDELRASRKLFTNGAVHDKGPLRRLRVLGGDVLCAGSVGQVYWLRDESFEPLPPLTVDGEAVTIEDLAGNSREDFIAVASDGYAAHFNGSTWQVLPLPIHTELTAICKLEQGYAICGKSGAVMTGSGDEWSDLTPFDGDRDYWGIASHQGTLYVAHLAGIDHASGQALRPLGLPKGAPLQFTVLRGASDGVWSFADHTIGRIHDGQWHTLTSGPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXK8</accession>
    <name>Q1CXK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6748"/>
    <dbReference type="EnsemblBacteria" id="ABF89238">
        <property type="protein sequence ID" value="ABF89238"/>
        <property type="gene ID" value="MXAN_6748"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6748"/>
    <dbReference type="HOGENOM" id="CLU_3397541_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="31" mass="3490" checksum="E38C77EB5353DFF5" modified="2006-07-11" version="1">MPLRVWAVLGPAGTDRTGKWLRELPGLDTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ1</accession>
    <name>Q1CXQ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556630.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6705"/>
    <dbReference type="EnsemblBacteria" id="ABF91346">
        <property type="protein sequence ID" value="ABF91346"/>
        <property type="gene ID" value="MXAN_6705"/>
    </dbReference>
    <dbReference type="GeneID" id="41363898"/>
    <dbReference type="KEGG" id="mxa:MXAN_6705"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032476_0_0_7"/>
    <dbReference type="OMA" id="IAKATHH"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="574" mass="60805" checksum="6BCD4E2C3F97E4BE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY87</accession>
    <name>Q1CY87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556444.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6513"/>
    <dbReference type="EnsemblBacteria" id="ABF86585">
        <property type="protein sequence ID" value="ABF86585"/>
        <property type="gene ID" value="MXAN_6513"/>
    </dbReference>
    <dbReference type="GeneID" id="41363721"/>
    <dbReference type="KEGG" id="mxa:MXAN_6513"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_7"/>
    <dbReference type="OMA" id="YYIWGAT"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="22002" checksum="C92EDAB6080C96EA" modified="2006-07-11" version="1">MSVEALFQTLESRLSSRPAREVHLPGWTLREASVLVPVFERDGVPHVLFTRRPATLRTHADQYSFPGGGRDPEDATPLHTALRETEEELGIDRRGVRVLGMLDEVPTISQYRVRPFVGVIPGDGKYRPSAEEVAFILEVPLSGLLDPSILRVEQKEIMGAERDLYFYTYGTHVIWGATARILRDFLNHVTQVPGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYE9</accession>
    <name>Q1CYE9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556382.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6450"/>
    <dbReference type="MEROPS" id="S12.A23"/>
    <dbReference type="EnsemblBacteria" id="ABF86572">
        <property type="protein sequence ID" value="ABF86572"/>
        <property type="gene ID" value="MXAN_6450"/>
    </dbReference>
    <dbReference type="GeneID" id="41363657"/>
    <dbReference type="KEGG" id="mxa:MXAN_6450"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030169_4_0_7"/>
    <dbReference type="OMA" id="IESMSAT"/>
    <dbReference type="OrthoDB" id="803444at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187987" evidence="1">
        <location>
            <begin position="23"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="57563" checksum="2382EB0F19A54B68" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI4</accession>
    <name>Q1CYI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ompa-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556347.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6415"/>
    <dbReference type="EnsemblBacteria" id="ABF92967">
        <property type="protein sequence ID" value="ABF92967"/>
        <property type="gene ID" value="MXAN_6415"/>
    </dbReference>
    <dbReference type="GeneID" id="41363625"/>
    <dbReference type="KEGG" id="mxa:MXAN_6415"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587704_0_0_7"/>
    <dbReference type="OMA" id="PSRKGYH"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="DUF3520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022156">
        <property type="entry name" value="Uncharacterised_YfbK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="DUF3520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12450">
        <property type="entry name" value="vWF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188046" evidence="1">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="vWF_A" evidence="2">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="48920" checksum="720FEF260B23EA12" modified="2006-07-11" version="1">MAPTMKPTPCNVFCVVLLLLSAPALAAGGLSGTVVRASDKSPIPEVRVTATSPALTEPRSTVTDAQGGFRFPQLADGVYSLRFEKESFQALSRTDITVKAGHEPRVDVALSAASQTRPSVLPPAPVDDDRERAPAWTLQHLPVLVPDGAWQTVYRASLGKPGSGVETRGFGVNPTIDTEESRTSEFPVAVDTSAYGVARDYLSRDVFPAEGAVRTEAFINSFDSGDEGEPYGPFLLYVEGFPSPSRKGYHVVRITVKAREPVREVGVQVEFNRKAVARYRLLGYEYLSPNPEPLDPGDETELFPLAAGQSVTAIHEVKVLGPSIAFGMLRVRYEQGNSSNWRRVQMMMPSSTLRSDYARAAPFTRLAYVASAFAEKLRGSFWTRALDWPRLLTLWEGIGEPLRTRKDVAQLGALIRKAQSLDTRKERFERLMPGGSSDFDDVPSLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYJ4</accession>
    <name>Q1CYJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6405"/>
    <dbReference type="EnsemblBacteria" id="ABF88457">
        <property type="protein sequence ID" value="ABF88457"/>
        <property type="gene ID" value="MXAN_6405"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6405"/>
    <dbReference type="eggNOG" id="ENOG5032MAT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674210_0_0_7"/>
    <dbReference type="OMA" id="FERAITQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="443" mass="48389" checksum="4F3D0DFF414D5BAD" modified="2006-07-11" version="1">MRSKRIAVFSPAGLPLFVGLLTGGLGTNAKAQAFQELLEQGSAGLQVLALDSERGLRENSLLNPGNRIARLPAGQTEVEGRLDLKLATDTFEVSLKPRARFEWRRFGETGPETRLDAWVNQGLVTLYPVQSLAVSLGRDVLMWGPSNFRSPSNPIYFENGRNNPMRELRGVDVAQATWSPTQALSLSLLHQFGDGRGDWQWEKEDGFKALSLLKVDYTAEASVVGLNASKRWAHERPHFGAFGQTTVGEALLLYAEGGLRQGTSALYPERLPNAVGGAFLPRHARDHRLIYSALAGGGYTLDSGHTVYLEYLSNNEGYRWADGARYFDIATRASSVLTLPSPDAALAGQTLGAALNNGLPLLGRHYLFMQVQNNPTDTGPTWQLRYSLNLVDGSGQASAYAEWNVWSRVALFALGVIHHGGPRTEFHSLLSQSILVGARGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYL0</accession>
    <name>Q1CYL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556321.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6389"/>
    <dbReference type="EnsemblBacteria" id="ABF87463">
        <property type="protein sequence ID" value="ABF87463"/>
        <property type="gene ID" value="MXAN_6389"/>
    </dbReference>
    <dbReference type="GeneID" id="41363600"/>
    <dbReference type="KEGG" id="mxa:MXAN_6389"/>
    <dbReference type="HOGENOM" id="CLU_194381_0_0_7"/>
    <dbReference type="OMA" id="CGRIACC"/>
    <dbReference type="OrthoDB" id="1953886at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027635">
        <property type="entry name" value="Lantibiotic2_lead_pep_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03898">
        <property type="entry name" value="lanti_MRSA_kill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="92" mass="9948" checksum="31EA6573A6C14F53" modified="2006-07-11" version="1">MAVPQQPKRSSTMSHSDKNHILRAWRNADYYDSLSDAERAALPASPASVMELEDATLAFITGGDAEATCPATPTPNELTCLYTNCGRIACCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYN0</accession>
    <name>Q1CYN0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556301.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6369"/>
    <dbReference type="EnsemblBacteria" id="ABF91336">
        <property type="protein sequence ID" value="ABF91336"/>
        <property type="gene ID" value="MXAN_6369"/>
    </dbReference>
    <dbReference type="GeneID" id="41363582"/>
    <dbReference type="KEGG" id="mxa:MXAN_6369"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164874_0_0_7"/>
    <dbReference type="OMA" id="LQECRGP"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="25946" checksum="2897E3869633B55D" modified="2006-07-11" version="1">MASRDGTRAGGAQETGKPPARPGGRREAHRREREQTLEDAALKLFLARGLDGVTIDDITQAAGVAKGTFYRYFDDKAALVDGLLEPVRRELLAGLETCGHSLAEARNVEAMFDAYRAVAAVIASALLQYPGVVRLYLQECRGPAVGARTKVAELARQVARHAVDITQKAHTSGLLRPIRPAVSGLAVVGAVERLLLAVLSEEDIGNPLELPDALTTLVLDGLRLPPEVRPGRRKLDGGPKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYP7</accession>
    <name>Q1CYP7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6352"/>
    <dbReference type="EnsemblBacteria" id="ABF91463">
        <property type="protein sequence ID" value="ABF91463"/>
        <property type="gene ID" value="MXAN_6352"/>
    </dbReference>
    <dbReference type="GeneID" id="41363566"/>
    <dbReference type="KEGG" id="mxa:MXAN_6352"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035903_0_0_7"/>
    <dbReference type="OMA" id="AGCYGNT"/>
    <dbReference type="OrthoDB" id="309160at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000126">
        <property type="entry name" value="V8_ser_AS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00673">
        <property type="entry name" value="V8_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006993340" description="Serine protease" evidence="3">
        <location>
            <begin position="31"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="56700" checksum="3463D8933DB58942" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV1</accession>
    <name>Q1CYV1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">MXAN_6297</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
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        <property type="protein sequence ID" value="ABF87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABF87952">
        <property type="protein sequence ID" value="ABF87952"/>
        <property type="gene ID" value="MXAN_6297"/>
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    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_7"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23602" checksum="E46AD21BD3186DD3" modified="2006-07-11" version="1">MSRRPVRISPSLLSCDFGRLAEEVRAIEAAGADWIHVDVMDGRFVPNITIGPVVVEAIKRVATKPLDVHLMIVEPERYVEAFVKAGADVLTVHVEASPHLHRTLQQIRNAGAKPAVVLNPGTPLSAIEEVLGDVDMVLLMSVNPGFGGQSFIESTVERVRRLRGMLDARGLKDVDIEVDGGINATTAKRVVEAGATVLVAGSYVFGSKDYAEAIRSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ18</accession>
    <name>Q1CZ18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556168.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6224"/>
    <dbReference type="EnsemblBacteria" id="ABF86891">
        <property type="protein sequence ID" value="ABF86891"/>
        <property type="gene ID" value="MXAN_6224"/>
    </dbReference>
    <dbReference type="GeneID" id="41363450"/>
    <dbReference type="KEGG" id="mxa:MXAN_6224"/>
    <dbReference type="eggNOG" id="COG4567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_6_7"/>
    <dbReference type="OMA" id="KTLEWEH"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19687" checksum="05C171C73ADDE206" modified="2006-07-11" version="1">MPPGEAPATVLVTDDDERFRERLVRAFVRHGFQAHGAASAHAALEAARALRPGYAVVDLRLPDGSGLELVRELKALDANTTVVVLTGYGSIATAVEAVRRGATHYLAKPADVDDILLAFAGATLPSGQEAALTHEVPSLARAEWEHIQRVLADCGGNISQAARLLRIQRRSLQRKLSKYPVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ46</accession>
    <name>Q1CZ46_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556140.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6196"/>
    <dbReference type="EnsemblBacteria" id="ABF92608">
        <property type="protein sequence ID" value="ABF92608"/>
        <property type="gene ID" value="MXAN_6196"/>
    </dbReference>
    <dbReference type="GeneID" id="41363425"/>
    <dbReference type="KEGG" id="mxa:MXAN_6196"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062228_0_0_7"/>
    <dbReference type="OMA" id="WDDSKVA"/>
    <dbReference type="OrthoDB" id="1533499at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021314">
        <property type="entry name" value="DUF2911"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11138">
        <property type="entry name" value="DUF2911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188188" evidence="1">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="30793" checksum="CE3C462056960232" modified="2006-07-11" version="1">MRTMKNQLLSCMASALMTLSAMPALAQLKLPASSPAAKVTQEVGVSEISVEYSSPAVKGRKVWGELVPNDKAWRSGANSATKITFSHPVTFGGKAVPAGSYAIVSLPSQKGWKVMLNTDLGLWRGGAPYDTSKDVASVSATTTEIPSRERLTYLFTDTTDNSTRLDLEWEKLRVSVPITVDTAAIAKANIEDAQKGIAGMHVSAASYVAEATKDYAAALKHADAAVAANGTWYNHWVRAGVLSQMGKYSEARKAAQTAWDLGQKDKNFFYRDQVSKALAEWKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZV6</accession>
    <name>Q1CZV6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variable surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555881.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5930"/>
    <dbReference type="EnsemblBacteria" id="ABF89449">
        <property type="protein sequence ID" value="ABF89449"/>
        <property type="gene ID" value="MXAN_5930"/>
    </dbReference>
    <dbReference type="GeneID" id="41363168"/>
    <dbReference type="KEGG" id="mxa:MXAN_5930"/>
    <dbReference type="HOGENOM" id="CLU_2602338_0_0_7"/>
    <dbReference type="OMA" id="VMCKVLA"/>
    <dbReference type="OrthoDB" id="2209674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032831">
        <property type="entry name" value="LPAM_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13627">
        <property type="entry name" value="LPAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187942" evidence="6">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="90" mass="8965" checksum="B915C2A5DC2069AF" modified="2006-07-11" version="1">MAGDAVLVMCKVLARLCVAASVSLMLAACGIKGPPRPPGPPPAPATQTQSPPPESERGPLEPSGPTLSPTPETGVETPLSPTESEDAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ7</accession>
    <name>Q1CZZ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2010-06" db="PDB data bank">
            <title>Crystal structure of a response regulator from Myxococcus xanthus.</title>
            <authorList>
                <person name="Palani K."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 18-139</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="3NHM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="A/B=18-139"/>
    </dbReference>
    <dbReference type="PDBsum" id="3NHM"/>
    <dbReference type="SMR" id="Q1CZZ7"/>
    <dbReference type="IntAct" id="Q1CZZ7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5889"/>
    <dbReference type="EnsemblBacteria" id="ABF88351">
        <property type="protein sequence ID" value="ABF88351"/>
        <property type="gene ID" value="MXAN_5889"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5889"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="VENSWTM"/>
    <dbReference type="EvolutionaryTrace" id="Q1CZZ7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3NHM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16336" checksum="454C7AB09BE4D251" modified="2006-07-11" version="1">MHRAPPGGCLPESRGVVKPKVLIVENSWTMRETLRLLLSGEFDCTTAADGASGLQQALAHPPDVLISDVNMDGMDGYALCGHFRSEPTLKHIPVIFVSGYAPRTEGPADQPVPDAYLVKPVKPPVLIAQLHALLARAEAVTPAAPTIQPAWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D022</accession>
    <name>Q1D022_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555815.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5864"/>
    <dbReference type="EnsemblBacteria" id="ABF88860">
        <property type="protein sequence ID" value="ABF88860"/>
        <property type="gene ID" value="MXAN_5864"/>
    </dbReference>
    <dbReference type="GeneID" id="41363103"/>
    <dbReference type="KEGG" id="mxa:MXAN_5864"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090584_0_0_7"/>
    <dbReference type="OMA" id="PKIHEHD"/>
    <dbReference type="OrthoDB" id="1335114at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025297">
        <property type="entry name" value="DUF4159"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13709">
        <property type="entry name" value="DUF4159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187758" evidence="1">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4159" evidence="2">
        <location>
            <begin position="41"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="28223" checksum="069A374E212597CF" modified="2006-07-11" version="1">MSARRLTRRNLLLGTAALAPLLARRAHAFGEKNRFIPAVARHKGRWDTRLSGLRRIAWELQRRTSVEVVPDARPFPLSSPDLFEYPFLYFGGEGEFPPLEEAEVANLRRYLTYGGFMLADANDASDGAGFDASFRREMARVLPQSPLAEVPSKHVVFKSFFLLDAAPGRVLNKPQLMGCNLGKRAAVLYSQNDLAGAWSRNESGDYEFDVSPGGEPQRELAVRLGINVCMYALCLDYKDDAVHLPLILNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0E1</accession>
    <name>Q1D0E1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555696.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5745"/>
    <dbReference type="ESTHER" id="myxxa-Q84FE8">
        <property type="family name" value="Carbon-carbon_bond_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91527">
        <property type="protein sequence ID" value="ABF91527"/>
        <property type="gene ID" value="MXAN_5745"/>
    </dbReference>
    <dbReference type="GeneID" id="41362988"/>
    <dbReference type="KEGG" id="mxa:MXAN_5745"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_7"/>
    <dbReference type="OMA" id="YAAMHPT"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="31158" checksum="D76385270076A806" modified="2006-07-11" version="1">MDLMGGMQKALRHMLVARGVESTTVQVGAQTVHHYALTGQGKGPPVVLVHGLGGSANGFGRTLFGMAKRFSRVYAPDLPGHGFSVEYCGGEVCVRNQFDVLRAYVEEVVKAPAFVVGNSLGGAMAVNLAAEYPEWVRALALVAPAGAQLPEAENTALLNSFVVKSPAEARAFTRRLFHRPPLPALLFAYELRHFYDTPTVRALTAEALATRACLEPEQVRNLAMPLLFLWGGSERLLPSETLKWYRAHLPAHAQVRVVDGFGHVPQLERPDELVSHLVRFADSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H9</accession>
    <name>Q1D0H9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Cytidine deaminase</fullName>
            <ecNumber evidence="6 9">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cdd</name>
        <name evidence="11" type="ORF">MXAN_5706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555658.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5706"/>
    <dbReference type="EnsemblBacteria" id="ABF87853">
        <property type="protein sequence ID" value="ABF87853"/>
        <property type="gene ID" value="MXAN_5706"/>
    </dbReference>
    <dbReference type="GeneID" id="41362951"/>
    <dbReference type="KEGG" id="mxa:MXAN_5706"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_0_1_7"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF87853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14320" checksum="D86A546581921E1F" modified="2006-07-11" version="1">MADEIPWERLFEEAARVRARAHVPYSRFPVGAAVLFADGAVVAGCNVENATYGLTVCAERNAFAAAVAQGHTQPVAVAIVVDTPEPCPPCGMCRQVMAEFGGQELPVRSRTPQGGEARYTLGGLLPHAFTKDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K3</accession>
    <name>Q1D0K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal cation transporter, zinc (Zn2+)-iron (Fe2+) permease (ZIP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555635.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5682"/>
    <dbReference type="EnsemblBacteria" id="ABF88935">
        <property type="protein sequence ID" value="ABF88935"/>
        <property type="gene ID" value="MXAN_5682"/>
    </dbReference>
    <dbReference type="GeneID" id="41362927"/>
    <dbReference type="KEGG" id="mxa:MXAN_5682"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_4_0_7"/>
    <dbReference type="OMA" id="HWHHCHR"/>
    <dbReference type="OrthoDB" id="1469769at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="27482" checksum="9955A2C8398E6D1E" modified="2006-07-11" version="1">MSPVLATVALYSLIIVLGALAGAVVVVLNDRPTHLVRFLAFAAGVMLGAAFFHMLPEAYLGGGWWAFALVPAGFAFLLVLERYLVAHAGEDISHGDTMAGTGHSVHPGHVLGLTAFLGLSTHTLFDGIALGSAVEEGVGGMALLAIVAHKVPSALSLASILKTEGRSKVSILSLSTLYGMMVPAGALLYFLFDAMLQFESLAAKALAFSAGTFLYIAVSDLLPHVHRHGKDQPGRNVLALFAGLLLMFLLARLMGHPEHPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K6</accession>
    <name>Q1D0K6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5679"/>
    <dbReference type="EnsemblBacteria" id="ABF92516">
        <property type="protein sequence ID" value="ABF92516"/>
        <property type="gene ID" value="MXAN_5679"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5679"/>
    <dbReference type="eggNOG" id="COG5398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057050_2_0_7"/>
    <dbReference type="OMA" id="ANRAFEY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="26951" checksum="A1D2B3D0DA8001D2" modified="2006-07-11" version="1">MEPQLPASPQQPQAATPAPLSVLLAEGTAKLAAQAERSLFIQSLFFDAWEGGIYGQYVRAQHYVSHLRQLHTLYAAFEAALPHVMGTTLTTALLLPELRLASALEADLTYFCGESRADTFACVETRLHAERIREVAEDAPHLLVAHAYARCVLDVFSGHRRARRITDAFELAEGQGTTFYGTVPEAGLAAFRVRFHSRIDGLELAEDETREVVQEARMAFRLHALVCDELARGATGIAAGPHADAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0P7</accession>
    <name>DNLJ_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">MXAN_5637</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555591.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0P7"/>
    <dbReference type="SMR" id="Q1D0P7"/>
    <dbReference type="STRING" id="246197.MXAN_5637"/>
    <dbReference type="EnsemblBacteria" id="ABF88435">
        <property type="protein sequence ID" value="ABF88435"/>
        <property type="gene ID" value="MXAN_5637"/>
    </dbReference>
    <dbReference type="GeneID" id="41362883"/>
    <dbReference type="KEGG" id="mxa:MXAN_5637"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_7"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313329" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="592"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="672" mass="74045" checksum="67E3D8F7D96A3D5D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0P9</accession>
    <name>Q1D0P9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87869">
        <property type="protein sequence ID" value="ABF87869"/>
        <property type="gene ID" value="MXAN_5635"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5635"/>
    <dbReference type="HOGENOM" id="CLU_2410178_0_0_7"/>
    <dbReference type="OMA" id="CGRCIPT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="92" mass="9140" checksum="D1EEC5BC632AA51C" modified="2006-07-11" version="1">MLGVTLGGGGVGCDGLEDLPLGDVPPVLSDKTCYTDDDCVADACCGLGTAVTHADEGPTCRAPCTSGCPEGSIDCGRCIPTCREARCAAACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R1</accession>
    <name>Q1D0R1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555577.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5623"/>
    <dbReference type="EnsemblBacteria" id="ABF88374">
        <property type="protein sequence ID" value="ABF88374"/>
        <property type="gene ID" value="MXAN_5623"/>
    </dbReference>
    <dbReference type="GeneID" id="41362869"/>
    <dbReference type="KEGG" id="mxa:MXAN_5623"/>
    <dbReference type="eggNOG" id="COG1913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568092_0_0_7"/>
    <dbReference type="OMA" id="WELHHCL"/>
    <dbReference type="OrthoDB" id="1265512at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="170" mass="19119" checksum="B0F4754F20B9193A" modified="2006-07-11" version="1">MIRVVTLDPFDDKQLAKFNRTLYTAFGVGSEHSDSVEVPAGMSEPLDAEKLIDEVKGIRSYKDDKVLLLTTRKLKDRELPSGVAPTAGFARQGKDRAILTIAPHKDLESAFKAVSRHALHQLGHLWELHHCLDPRCSMYPPWTPSFAQGEAIFCTFCREKSEQKIRLAKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0S7</accession>
    <name>MRAY_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">MXAN_5607</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555561.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0S7"/>
    <dbReference type="SMR" id="Q1D0S7"/>
    <dbReference type="STRING" id="246197.MXAN_5607"/>
    <dbReference type="EnsemblBacteria" id="ABF91493">
        <property type="protein sequence ID" value="ABF91493"/>
        <property type="gene ID" value="MXAN_5607"/>
    </dbReference>
    <dbReference type="GeneID" id="41362853"/>
    <dbReference type="KEGG" id="mxa:MXAN_5607"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_7"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000332539" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="392" mass="42590" checksum="246E143F57DE29B4" modified="2006-07-11" version="1">MLYLLYEVIQNSEAGRVLNFLRYPTFRIIAAGVFALLLGMLIGPKLIARLRLKQHGQSNVREDTPDSHQKKKGTPTMGGALILLCIAAGTLLFADLKSRAVWVMLLLTLGYGFIGFLDDWLKLSKRNSKGLAGRKKMVLQTFFFLVAVFGLLTTWTLPDGSFGPTLLINTKLTLPFIPTRWFNPDLGWFYVFFAWIVVVGTSNAVNLTDGLDGLAIVPTIVSAITFAVLCYVAGTTLSIADYEVVGGASKLVATPLYQYLGILQVPGGAELAVFCAAIVGAGISFLWFNTYPASVFMGDIGSLALGGALGGLAMLSKNEVVSAIIHGIFFAEILSVMIQVTSFKMTGKRVFKMAPVHHHFELKGMAEPKIIVRFWIVSILCGGVALLSLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0W3</accession>
    <name>Q1D0W3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555525.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5571"/>
    <dbReference type="EnsemblBacteria" id="ABF91218">
        <property type="protein sequence ID" value="ABF91218"/>
        <property type="gene ID" value="MXAN_5571"/>
    </dbReference>
    <dbReference type="GeneID" id="41362818"/>
    <dbReference type="KEGG" id="mxa:MXAN_5571"/>
    <dbReference type="HOGENOM" id="CLU_737368_0_0_7"/>
    <dbReference type="OMA" id="SPTHLAY"/>
    <dbReference type="OrthoDB" id="938517at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="383" mass="41634" checksum="A668573E951D6401" modified="2006-07-11" version="1">MEPNKDPFLLTPQLPAAAAPVRHPSPFPWNQVALVFPSPAPDSVSVLTLNDKLWRLELSGSEVRRVEVDDEYLEQVSGGELQGMQPPSPTHLAYLQSRSLVMYDLKWQLAKTWFMVERLEEVAIRGAWISHAPLVVAAELEDTTNYARTSRISFRLRTWRLEGEKRAKLGSLELGSVVGAVKWDAGAGLVAVQKPGVPLELYGPDLARPQPEHPLALALRKLTVDGLTLQSLRLHPSLPVALVALGRDVTPKREEGKEKPEDPGIWRVSWEGAPAVTVRLARYASGESVTLGSLSPEGDWLYYRVLNSAGRNPQLYVQQVGAAFKPPLALGAVPEKGAALLWTGGAPSLVMYDGTKDALVHWKLAGAAAPAKPPAAPPKPDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D189</accession>
    <name>Q1D189_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5441"/>
    <dbReference type="EnsemblBacteria" id="ABF86962">
        <property type="protein sequence ID" value="ABF86962"/>
        <property type="gene ID" value="MXAN_5441"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5441"/>
    <dbReference type="HOGENOM" id="CLU_1128119_0_0_7"/>
    <dbReference type="OMA" id="HESGASY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="30064" checksum="1B7B9F0B7055AD15" modified="2006-07-11" version="1">MQSNAQPHRKAFAGRWAAPAVALVILSAAALYTALMRGRPGTPPPDDGMPPRPGASSGALAGEPARITAKATVPTSAPPGRELRPLTRPLPGEAAPPPAPDTGIEETRRDAIQKAARSYREGRFNVFFREEAFIQELANHGVENVAALQDALADTRSLSALPDDTRFTEQRPETVLDRMAMIDLLHTLAPEDDSARAAMLALATSPIDPSLSDVAKKGLVGEKYDLFFKLAQIDRQAAVDAFGRLDNPKLRSLLREALLAGLHESGASYEEVQRLTRHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I1</accession>
    <name>PYRH_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="ordered locus">MXAN_5342</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555307.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D1I1"/>
    <dbReference type="SMR" id="Q1D1I1"/>
    <dbReference type="STRING" id="246197.MXAN_5342"/>
    <dbReference type="EnsemblBacteria" id="ABF91626">
        <property type="protein sequence ID" value="ABF91626"/>
        <property type="gene ID" value="MXAN_5342"/>
    </dbReference>
    <dbReference type="GeneID" id="41362611"/>
    <dbReference type="KEGG" id="mxa:MXAN_5342"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_7"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000323900" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="250" mass="27077" checksum="6535983952D13659" modified="2006-07-11" version="1">MSSDTKKPLPYQRILLKLSGEALMGEGKYGIHPPTLMGIAEEVIELAQAGVEVALVIGGGNIFRGVAGATEGMDRASADYMGMLATCINSMAMQDALEKKGLHTRVLSAIKMEQIAEPYIRRRAVRHLEKGRVVIFAAGTGNPYFTTDTAASLRAMEINAQVILKATKVDGVYSADPKKDPTARRYRSLTYMDVLKQNLNVMDSTAISLCMDNKLPIIVFDLTQRGNIRRAVLGEGDIGTLVGGSETVWA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I2</accession>
    <name>RRF_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">MXAN_5341</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555306.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D1I2"/>
    <dbReference type="SMR" id="Q1D1I2"/>
    <dbReference type="STRING" id="246197.MXAN_5341"/>
    <dbReference type="EnsemblBacteria" id="ABF90662">
        <property type="protein sequence ID" value="ABF90662"/>
        <property type="gene ID" value="MXAN_5341"/>
    </dbReference>
    <dbReference type="GeneID" id="41362610"/>
    <dbReference type="KEGG" id="mxa:MXAN_5341"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_7"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000074588" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="185" mass="20913" checksum="93798C476F16222E" modified="2006-07-11" version="1">MSGDVVAELKGRIDKSLEGLRTDLTRVRTGRASIAILEGVRVDYYGTPTPLSGVASVNAPEPRLITIKPWEKSVLKDIEKALREANLGINPMNDGEMIRLPFPPLTEERRKDIAKQVKTKGEEFKVTIRNLRRDANEVLKTQLKDKKITEDDHKRITEVVQKQTDAGITQVDEIVKKKEKEVMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I6</accession>
    <name>Q1D1I6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5337"/>
    <dbReference type="EnsemblBacteria" id="ABF88615">
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        <property type="gene ID" value="MXAN_5337"/>
    </dbReference>
    <dbReference type="GeneID" id="41362606"/>
    <dbReference type="KEGG" id="mxa:MXAN_5337"/>
    <dbReference type="HOGENOM" id="CLU_1213146_0_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187806" evidence="1">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="24331" checksum="6D4806CE8142EDEB" modified="2006-07-11" version="1">MRVRKVLWGLWVLVAFSACKKPEDASGPPAGVVGEQAPGAPDGVVEAGPYTVTKEKLDAYVGYQRRMLEVYGSLMKGLQNLGALVDAGTPEAMAAAREGLKVVEAKAKAEAEARREAQLSEADVNGIAEVVTAVVSQRQLGRTLQYEEELKKLEALQAKLPPEQQQGMAPQVASMRAQVEAFQTLADARRDYGDANIDVVLTREEDLIQNYQEMIRVFTGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1K3</accession>
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        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5319"/>
    <dbReference type="EnsemblBacteria" id="ABF88158">
        <property type="protein sequence ID" value="ABF88158"/>
        <property type="gene ID" value="MXAN_5319"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357429_0_0_7"/>
    <dbReference type="OMA" id="IRWGEHG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="688"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="761"/>
            <end position="794"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="841" mass="90666" checksum="3C3306B5C46CD359" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L3</accession>
    <name>Q1D1L3_MYXXD</name>
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        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_5309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5309"/>
    <dbReference type="EnsemblBacteria" id="ABF90721">
        <property type="protein sequence ID" value="ABF90721"/>
        <property type="gene ID" value="MXAN_5309"/>
    </dbReference>
    <dbReference type="GeneID" id="41362579"/>
    <dbReference type="KEGG" id="mxa:MXAN_5309"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170979_0_0_7"/>
    <dbReference type="OMA" id="MRLWENE"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="13322" checksum="DE2D5BAADD92C38F" modified="2006-07-11" version="1">MGDTSVKKVESRHSPKGEMGQKYLASGVRLSMRLWEDEPPGEPAPATARDYETVGFVLKGRAELHLEGQVILLNPGDSWLVPRGSSHTYKVLETFSAVEATSPPAAVHGRDEGKDAGTKPPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W3</accession>
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        <submittedName>
            <fullName evidence="1">SocA oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">socA</name>
        <name evidence="1" type="ORF">MXAN_5208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5208"/>
    <dbReference type="EnsemblBacteria" id="ABF87303">
        <property type="protein sequence ID" value="ABF87303"/>
        <property type="gene ID" value="MXAN_5208"/>
    </dbReference>
    <dbReference type="GeneID" id="41362490"/>
    <dbReference type="KEGG" id="mxa:MXAN_5208"/>
    <dbReference type="eggNOG" id="COG1028">
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    </dbReference>
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    <dbReference type="OMA" id="VGTLGKQ"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="248" mass="25262" checksum="F8539392F21BA888" modified="2006-07-11" version="1">MDMMAFSGKAALVTGGTRGIGAAIVRHLAKGGADVAFTYANSGDKAATLVGELKALGRRAVAIQADNGDPDAVRGAVDRAASELGRLDILVNNAGIFPSGPFEKVTLEELDRTLAIHVRGVFVASQAALAHMPQGGRIISIGSCFAQRVPYGGVTLYSMSKSALIGLTKGLAREVGERGITVNVIDPGSTDTDMNPATGPAVAAELALMSLKHYAQPEDIAATVGHLASASGRFITGTSIAVDGGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z8</accession>
    <name>Q1D2Z8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554800.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4814"/>
    <dbReference type="EnsemblBacteria" id="ABF92904">
        <property type="protein sequence ID" value="ABF92904"/>
        <property type="gene ID" value="MXAN_4814"/>
    </dbReference>
    <dbReference type="GeneID" id="41362113"/>
    <dbReference type="KEGG" id="mxa:MXAN_4814"/>
    <dbReference type="eggNOG" id="ENOG50319FX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069345_0_0_7"/>
    <dbReference type="OMA" id="RHARIMP"/>
    <dbReference type="OrthoDB" id="609834at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188178" evidence="2">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="364" mass="38853" checksum="5517135B068CA425" modified="2006-07-11" version="1">MKRTLQASAVALSLLAGCATVPKPSMCFAEAGPNARSFPTPDTWFALLLHGYDKDTGANPRPSVDCAGAPVWWQDPAADECVEAGPDSQALPPAEKLSEEDLVLETLQAGQRLVWVQTRRFTNGEALGPVALVESTEQGFRVEALGSLRAMAKHTKLRLEKVKGTPILVAEGDACTSGDEEVCRRHARIMPLRTNRFFSESVSNASRACLGAAWFPLSREMTFELPNGLRRKFELTSTLTFAEEGISVQEQVQVSDSDPAQPDVAPRLYRRAQDTRNLELAKNALVGNKASLWSRMVEQQVRIGARAVPEAPIWAMPAKKAPTDAAAPEAASKAQAPATTGAASPPAKAAAKKPAGSTATSSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D364</accession>
    <name>Q1D364_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SusD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554734.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4747"/>
    <dbReference type="EnsemblBacteria" id="ABF92711">
        <property type="protein sequence ID" value="ABF92711"/>
        <property type="gene ID" value="MXAN_4747"/>
    </dbReference>
    <dbReference type="GeneID" id="41362046"/>
    <dbReference type="KEGG" id="mxa:MXAN_4747"/>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619487_0_0_7"/>
    <dbReference type="OMA" id="EGHRWID"/>
    <dbReference type="OrthoDB" id="758760at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012944">
        <property type="entry name" value="SusD_RagB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07980">
        <property type="entry name" value="SusD_RagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SusD_RagB" evidence="5">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="48930" checksum="6C5B04B1E29CE11E" modified="2006-07-11" version="1">MTIQLTKKAFVGLFTVLGLSGCGSLDVPDLNNPSLDDFRERPTRPAVLTAATGLLLGHRAGVAAPNGYVAQLGIIGREAYVFDPADPRAVGELLGPTLDPGGPAFGGNHWTNPYLNIRNANALLDSLDQVPNTPDAEKEGLRGFAKTMQALDFLVVINTRDIEGAPIDVNLPIGQLAPIVGKEAVFERIAALLDEGHAHLGSAGESFPFQLSPGFAGFNTPTTFRQFNRALAARVAVYRGRYPEALTALSQSFLNQSASLDLGVYHSFGTNSGDTDNGLISVNVYAHPSIVTDAEFQENDTVDDRVVRKLTRLPEPRTAADGKLSTEWRFRIYPTNNSPVPIIRNEELILLRAEANIGDRNLGPAVDDLNFIRTTSGRLPPRLDIDENNALDELLKQKRYSLLFEGGHRWIDLRRYGRLDTLPRELDPDIEPHERFPIPAAEMNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B9</accession>
    <name>Q1D3B9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ</name>
        <name evidence="9" type="ORF">MXAN_4688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4688"/>
    <dbReference type="EnsemblBacteria" id="ABF90467">
        <property type="protein sequence ID" value="ABF90467"/>
        <property type="gene ID" value="MXAN_4688"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4688"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_7"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="327"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="462"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="573" mass="61739" checksum="C0D08C2ADA1BFA7B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L0</accession>
    <name>Q1D3L0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554590.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4595"/>
    <dbReference type="EnsemblBacteria" id="ABF88948">
        <property type="protein sequence ID" value="ABF88948"/>
        <property type="gene ID" value="MXAN_4595"/>
    </dbReference>
    <dbReference type="GeneID" id="41361895"/>
    <dbReference type="KEGG" id="mxa:MXAN_4595"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_7"/>
    <dbReference type="OMA" id="AVYNCYG"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121838" checksum="8352A8AB420BF09D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T5</accession>
    <name>Q1D3T5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4520"/>
    <dbReference type="EnsemblBacteria" id="ABF87512">
        <property type="protein sequence ID" value="ABF87512"/>
        <property type="gene ID" value="MXAN_4520"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4520"/>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459838_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20490" checksum="2A4E655F787FEEF9" modified="2006-07-11" version="1">MAQAGLMPDLHHVEGGPMPSMTCRVVTTQQELDDALRVRWVVFGGEMRLMAGQEFPTQREVNGFDKLSSTVHLVVYVEHGPVATVRILLPNPEVASATGGVLGVEMEHRLDLTGLVEPGQVVAEAARFCVHRQWRHSDAVVLLQAAFYAESRRRGVTTGLPGRIWRRTRRWMRASSSRPLPTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U5</accession>
    <name>Q1D3U5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4509"/>
    <dbReference type="EnsemblBacteria" id="ABF91047">
        <property type="protein sequence ID" value="ABF91047"/>
        <property type="gene ID" value="MXAN_4509"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4509"/>
    <dbReference type="eggNOG" id="COG3107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460664_0_0_7"/>
    <dbReference type="OMA" id="DINPGWV"/>
    <dbReference type="OrthoDB" id="2044431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="595" mass="63414" checksum="C2F25CBA42375066" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D429</accession>
    <name>Q1D429_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554422.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4423"/>
    <dbReference type="EnsemblBacteria" id="ABF88148">
        <property type="protein sequence ID" value="ABF88148"/>
        <property type="gene ID" value="MXAN_4423"/>
    </dbReference>
    <dbReference type="GeneID" id="41361736"/>
    <dbReference type="KEGG" id="mxa:MXAN_4423"/>
    <dbReference type="HOGENOM" id="CLU_2509210_0_0_7"/>
    <dbReference type="OMA" id="RIHQSEY"/>
    <dbReference type="OrthoDB" id="1981403at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="85" mass="9268" checksum="701FED7E502B0BD3" modified="2006-07-11" version="1">MQDGSASPLSPEAPSSPAATEVSVDVRGPDADIVSTHVLVPEEQVQKLRELARRTRIHQSEYLREAVDDLLGKYGRGEPKEEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H3</accession>
    <name>Q1D4H3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_cc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4275"/>
    <dbReference type="CAZy" id="GH128">
        <property type="family name" value="Glycoside Hydrolase Family 128"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88289">
        <property type="protein sequence ID" value="ABF88289"/>
        <property type="gene ID" value="MXAN_4275"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4275"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_6_2_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Unchr_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_cc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="22691" checksum="7ED5A09A117F169A" modified="2006-07-11" version="1">MGAARIESILRANPRIQYLLLLNEPNLTDQANMSPQAAAELWPRYERVAQNTGVKLVGPAMNWGTLSGYGDPVDWLDAFYSAYRAANGNRDPHIDYLGFHWYDYGLDYNLDRLTKYGKPFWVTEFANCHSQPDGAQIDSVAKQRVQMTEMVAVCERREDVFRYAWFTGRWTNDPCFASLLGAAGTLTELGEHYVSLPTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4W3</accession>
    <name>Q1D4W3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91971">
        <property type="protein sequence ID" value="ABF91971"/>
        <property type="gene ID" value="MXAN_4135"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4135"/>
    <dbReference type="HOGENOM" id="CLU_3254458_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="42" mass="4551" checksum="E204775C17E64C0C" modified="2006-07-11" version="1">MVFCRPAGPKESLRVIIEKLELSPHHRPRSRAGPSGAREGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Y0</accession>
    <name>Q1D4Y0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90508">
        <property type="protein sequence ID" value="ABF90508"/>
        <property type="gene ID" value="MXAN_4114"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4114"/>
    <dbReference type="HOGENOM" id="CLU_3366019_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="35" mass="3789" checksum="165BD0D8DD164C1C" modified="2006-07-11" version="1">MGERIREVGQGPDGAIWLLQDGKAGRLLKLTPKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D504</accession>
    <name>Q1D504_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554098.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D504"/>
    <dbReference type="STRING" id="246197.MXAN_4091"/>
    <dbReference type="EnsemblBacteria" id="ABF91290">
        <property type="protein sequence ID" value="ABF91290"/>
        <property type="gene ID" value="MXAN_4091"/>
    </dbReference>
    <dbReference type="GeneID" id="41361420"/>
    <dbReference type="KEGG" id="mxa:MXAN_4091"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1576814_0_0_7"/>
    <dbReference type="OMA" id="WAGWIHA"/>
    <dbReference type="OrthoDB" id="1992557at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="170" mass="18052" checksum="E446D38979EBF02D" modified="2006-07-11" version="1">MSEHVSPQELRRKWKLANAEPLEGGHRLEAYRALAQSCPAFVPNLLSLSRTLLAGRNEAADPEAAVSEAEQVLRSASDVSAGAPEPLLALGHFLVSVRQAPDEAERAFSSAASAAMALLEEAWAGWIHALGAQGQLEAALEVEERARSLFPSSKAISQAVAFARAQSGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D562</accession>
    <name>Q1D562_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4032"/>
    <dbReference type="EnsemblBacteria" id="ABF88979">
        <property type="protein sequence ID" value="ABF88979"/>
        <property type="gene ID" value="MXAN_4032"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4032"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507824_0_0_7"/>
    <dbReference type="OMA" id="GIEHSPG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188150" evidence="1">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="255"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="392"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="504" mass="53960" checksum="D887FF6A7C311BF8" modified="2006-07-11" version="1">MMALLPLIAVLAATPPASAGMERSAAQHVSREFERVGRRAPVEDPKLTTAARRLAHEALTEYTTGAPGLFTLTSAVSDAGAADPSPRALVIRAWVPQHAVETFLDRDDFNSERASHFGVGVSVLGKRAALVLLLVDRKAELQDFPRLIANGERSTMTLCGALVPPLRRAEVYVTQPNGGVSLMPVQNRGAGGGFCSRLAFATPGTYTVEVVGRADGGPEVAALFLVDQGEPRKHAASEDTAEPTTLEDARRAVYERINALRRAHALPELSPDAVLEQVAQDYSARMSKEGFFAHIAPDGSTLTKRLPAGARYVRAGENLGLAPGPLAAHFGIEHSPGHRRNVLDPGFRFMGVGVAFHTVNGRQEAVLTEVFTVAPPASPELADPQQEAYDALSRRRASRKLPPLTRNAALETLARAHARRALELDQPSAQPGEAPVHDRVFELLPDAGTASVDFFVVSDPTAIPESRSMADATNNRVGVGVVRGDSRRFGTNQYWVAVIYAAVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6I1</accession>
    <name>RL19_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name type="ordered locus">MXAN_3549</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553578.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6I1"/>
    <dbReference type="SMR" id="Q1D6I1"/>
    <dbReference type="STRING" id="246197.MXAN_3549"/>
    <dbReference type="PRIDE" id="Q1D6I1"/>
    <dbReference type="EnsemblBacteria" id="ABF91840">
        <property type="protein sequence ID" value="ABF91840"/>
        <property type="gene ID" value="MXAN_3549"/>
    </dbReference>
    <dbReference type="GeneID" id="41360894"/>
    <dbReference type="KEGG" id="mxa:MXAN_3549"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_7"/>
    <dbReference type="OMA" id="SPMIESV"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000252522" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="127" mass="14514" checksum="3CF650788754B07B" modified="2006-07-11" version="1">MRNAAIQHIEAKFLRQDVTVFNTGDSVRVHWKVKEGEKERVQAFEGIVIRKTKGNHRATFTVRKLSFGVGVERVFPLHSPRYEKIEVLSRGDVNRKRLFYLRALKGKAARVDVIEEPKPSKKAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L3</accession>
    <name>Q1D6L3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87413">
        <property type="protein sequence ID" value="ABF87413"/>
        <property type="gene ID" value="MXAN_3516"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3516"/>
    <dbReference type="HOGENOM" id="CLU_1466727_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="20139" checksum="6DCB48157708031C" modified="2006-07-11" version="1">MARLGVFTPLSYAPGHLSGGLRSRPGYPRLRGVLPGLEGRRTGSTTVVVVLVLVVVLLVVDVLVLVLIEVVVLRFVLVVFLVVVVEHVLQVFGLQRHGHGEPLVERGNLRAHLRERCDEVLREVGGRLGVAMRADDFFSPFDEVLSVQLEARLALLAGEVDAHGRARHTKHSNQLSTSETGGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L8</accession>
    <name>Q1D6L8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotase</fullName>
            <shortName evidence="6">DHOase</shortName>
            <ecNumber evidence="6">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrC</name>
        <name evidence="8" type="ORF">MXAN_3511</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553541.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3511"/>
    <dbReference type="EnsemblBacteria" id="ABF91460">
        <property type="protein sequence ID" value="ABF91460"/>
        <property type="gene ID" value="MXAN_3511"/>
    </dbReference>
    <dbReference type="GeneID" id="41360856"/>
    <dbReference type="KEGG" id="mxa:MXAN_3511"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_7"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="55"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="46552" checksum="2392CB20862368DF" modified="2006-07-11" version="1">MSSTVLFRRGRVIDPRNGVDGVRDVLVRDGKVVEVSVTLLPVPSSAEVVDATGKWVLPGFIDLHVHLREPGEEGKETVLTGCRAAVAGGFTAVVAMPNTKVVNDNAMVTELVLNRARAAGLCHVYPAGAITKGLKGEELAEMGELVSAGCVAITDDGRPVMNASLMRRTLQYATQFDVPVMVHEEDLTLSAGGAMHEGTTSTRLGLRGIPASAEVAMVARDLVLLEETKGRLHVAHVSCEGSVRLIREAKRSGLRVTCEVAPHHFILDDRAVGDYDTHAKMAPPLRADTDVQALREALVDGTVDAIATDHAPHGVLDKQVEFEKGINGIVGLETALGLTLELVHAGVLTANRAVELLTHGPAKAFGLPGGHLAPGAPADVTVVDPDAEWTVDAHQFHSRSRNTPFHGRKQKGRVIQTWVAGHKVFDKGQVGQSKESR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6M1</accession>
    <name>LEPA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">MXAN_3508</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553538.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6M1"/>
    <dbReference type="SMR" id="Q1D6M1"/>
    <dbReference type="STRING" id="246197.MXAN_3508"/>
    <dbReference type="EnsemblBacteria" id="ABF90468">
        <property type="protein sequence ID" value="ABF90468"/>
        <property type="gene ID" value="MXAN_3508"/>
    </dbReference>
    <dbReference type="GeneID" id="41360853"/>
    <dbReference type="KEGG" id="mxa:MXAN_3508"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_7"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000265678" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="603" mass="66910" checksum="20A7079470FD7BC2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6V9</accession>
    <name>Q1D6V9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3417"/>
    <dbReference type="EnsemblBacteria" id="ABF90780">
        <property type="protein sequence ID" value="ABF90780"/>
        <property type="gene ID" value="MXAN_3417"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3417"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009318_3_2_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="36131" checksum="A3A8BAC3F4C7E28E" modified="2006-07-11" version="1">MERMKPTLWMMPFLTALAMSGCADKDPNSFPVLEKDAVFVVNGGSNSLSVIDVERQEVTSTLRLKDMTYPHHISLSPDRSLLVVAVPGMDLSGGHGGGHGGHSMPGKLLLLDAKTGKTRATRQFDVMTHNGAFSPDGTEVWTALMAKPGAVVVLDSQTLEPKQTIDVGDMPAEVTFSQDGRYAFVANGDSNNVSVINAATKAVVKTVTVGANPVGAWPGNDGLMYVDNEDGKSLTGIDASTLDVARTYPLGFTPAMAATAPNGDLWVTDTDNGKVIFFAAGTTTRQGELATGAGAHGIAFSADGATSFITNQTAGTLSIVDVASRTVRKTLTVGTQPNGLVFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7C1</accession>
    <name>Q1D7C1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c-type biogenesis protein CcmF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ccmF</name>
        <name evidence="10" type="ORF">MXAN_3253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553298.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3253"/>
    <dbReference type="EnsemblBacteria" id="ABF88151">
        <property type="protein sequence ID" value="ABF88151"/>
        <property type="gene ID" value="MXAN_3253"/>
    </dbReference>
    <dbReference type="GeneID" id="41360605"/>
    <dbReference type="KEGG" id="mxa:MXAN_3253"/>
    <dbReference type="eggNOG" id="COG1138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015041_3_0_7"/>
    <dbReference type="OMA" id="LMMALWV"/>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003568">
        <property type="entry name" value="Cyt_c_biogenesis_CcmF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01411">
        <property type="entry name" value="CCMFBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
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                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Durkin A.S."/>
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        <location>
            <begin position="576"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="ABF86780.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D851</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553019.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2963"/>
    <dbReference type="EnsemblBacteria" id="ABF89154">
        <property type="protein sequence ID" value="ABF89154"/>
        <property type="gene ID" value="MXAN_2963"/>
    </dbReference>
    <dbReference type="GeneID" id="41360326"/>
    <dbReference type="KEGG" id="mxa:MXAN_2963"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_1_2_7"/>
    <dbReference type="OMA" id="FKPMDMG"/>
    <dbReference type="OrthoDB" id="1982614at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039543">
        <property type="entry name" value="POX18/UbiT/NSL-TP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="PTHR10094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="11669" checksum="547832BD52F8F7FD" modified="2006-07-11" version="1">MSAKDIIENQIPETLKAKPELAKEINAVIVFDVSGEGGGKWTLDATKSEGWVTEGAVDNAKMTISVSNDDFVKIREKKLNAQMAAMQGKLKFKPMDMGLAMKLAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8B8</accession>
    <name>Q1D8B8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAP NTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2894"/>
    <dbReference type="EnsemblBacteria" id="ABF89014">
        <property type="protein sequence ID" value="ABF89014"/>
        <property type="gene ID" value="MXAN_2894"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2894"/>
    <dbReference type="eggNOG" id="COG4928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321022_0_0_7"/>
    <dbReference type="OMA" id="VTHELHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="216"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="903" mass="101204" checksum="DBB37A77858A62D2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G3</accession>
    <name>Q1D8G3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R2K_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552910.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2849"/>
    <dbReference type="EnsemblBacteria" id="ABF88928">
        <property type="protein sequence ID" value="ABF88928"/>
        <property type="gene ID" value="MXAN_2849"/>
    </dbReference>
    <dbReference type="GeneID" id="41360220"/>
    <dbReference type="KEGG" id="mxa:MXAN_2849"/>
    <dbReference type="eggNOG" id="ENOG502Z879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040789_0_0_7"/>
    <dbReference type="OMA" id="EVNDGGV"/>
    <dbReference type="OrthoDB" id="845510at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025643">
        <property type="entry name" value="R2K_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14243">
        <property type="entry name" value="R2K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R2K_3" evidence="1">
        <location>
            <begin position="165"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="35349" checksum="F4862A0E47F99FE9" modified="2006-07-11" version="1">MSGLARARVGGAPHTPPPLMRGFWMPGSRRPSHAHAILFGRNPTQDDPFDVEADAAEALGVDTYQADLGALLSGNAEQALSTLPERGRLRLLYRGWMLTEEEYTGLDEAVSALGHRLTTTPEQYAAALYLPNWYPRLSRYTARSVWTEGMDAAEAWHAAQALGPQPWLVKDHVKSAKERWDEACFIPEGTTQARFEQICANLVDERGDRFERGLVVRKFLPFKTYGRTPAGPAHLEFRLFFGGGRLLAAEPYHEFDVDVPDFTGFEPLARRIDSPFITLDVAMLQDGGWAVVEVNDGGVSGLPPGLDPRTLFEALFAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K5</accession>
    <name>Q1D8K5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, delta subunit</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">holA</name>
        <name evidence="1" type="ORF">MXAN_2801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552868.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2801"/>
    <dbReference type="EnsemblBacteria" id="ABF90135">
        <property type="protein sequence ID" value="ABF90135"/>
        <property type="gene ID" value="MXAN_2801"/>
    </dbReference>
    <dbReference type="GeneID" id="41360177"/>
    <dbReference type="KEGG" id="mxa:MXAN_2801"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587479_0_0_7"/>
    <dbReference type="OMA" id="HAREEEF"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="47848" checksum="D919074584AF2FE4" modified="2006-07-11" version="1">MSASEMDDVLASVKGGKVAPVYLLVGEEFLVRKGADELVKLLVPDAAMGLNLAVLDAGSPREVAQELATLPLFPGRKVVLVRDPEFLAPKKGRGDALGKAREAWKAGKRKEGARRLLALAARAGWGVDQLDPSTPGAPSVEKWKDELNVELADVDVAFLKEAAAFCREERISAPEGDASALLDLIQKGVPAGHALVLAASDMDAKNPLVKLAHDKGYVVERKVAARHKDLDLTDIAKEFLAPFKKKLGPGALDELKERIGGNIRLLQSELEKLATYSEGPAIERADVAALVHHAREEEFFELSEALQKRDFGGALSYANDAMGQGTHALQLLGAVASIVRGLLESHEWLWRYAGGNPPRTAKDVEARVFPRLEAELKGSKRKMPNAWALTFSMKAAAGYERRELLGALVACAEADLALKSSANGRLVIERLLATVCVRQHGAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R8</accession>
    <name>Q1D8R8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552805.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2738"/>
    <dbReference type="EnsemblBacteria" id="ABF86925">
        <property type="protein sequence ID" value="ABF86925"/>
        <property type="gene ID" value="MXAN_2738"/>
    </dbReference>
    <dbReference type="GeneID" id="41360115"/>
    <dbReference type="KEGG" id="mxa:MXAN_2738"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009368_0_0_7"/>
    <dbReference type="OMA" id="ARMDEAN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="67"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113660" checksum="9D7ECF8B26D6A9AF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8X3</accession>
    <name>Q1D8X3_MYXXD</name>
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        <submittedName>
            <fullName evidence="7">Methyl accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mcp</name>
        <name evidence="7" type="ORF">MXAN_2683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552751.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2683"/>
    <dbReference type="EnsemblBacteria" id="ABF86464">
        <property type="protein sequence ID" value="ABF86464"/>
        <property type="gene ID" value="MXAN_2683"/>
    </dbReference>
    <dbReference type="GeneID" id="41360061"/>
    <dbReference type="KEGG" id="mxa:MXAN_2683"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="QQSAMAH"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="266"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="56517" checksum="DAB8859431C6E8D5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D968</accession>
    <name>Q1D968_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552656.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2586"/>
    <dbReference type="EnsemblBacteria" id="ABF92121">
        <property type="protein sequence ID" value="ABF92121"/>
        <property type="gene ID" value="MXAN_2586"/>
    </dbReference>
    <dbReference type="GeneID" id="41359964"/>
    <dbReference type="KEGG" id="mxa:MXAN_2586"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_151_5_7"/>
    <dbReference type="OMA" id="YEFGEAN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="762" mass="83120" checksum="04671C3F0B2A71BE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D987</accession>
    <name>Q1D987_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase, M50A (S2P protease) subfamily</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_2567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552637.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2567"/>
    <dbReference type="EnsemblBacteria" id="ABF91744">
        <property type="protein sequence ID" value="ABF91744"/>
        <property type="gene ID" value="MXAN_2567"/>
    </dbReference>
    <dbReference type="GeneID" id="41359945"/>
    <dbReference type="KEGG" id="mxa:MXAN_2567"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_4_0_7"/>
    <dbReference type="OMA" id="GPTQYNP"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="530" mass="52438" checksum="B0EDC3A16E560141" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9N0</accession>
    <name>Q1D9N0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552498.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2423"/>
    <dbReference type="EnsemblBacteria" id="ABF86307">
        <property type="protein sequence ID" value="ABF86307"/>
        <property type="gene ID" value="MXAN_2423"/>
    </dbReference>
    <dbReference type="GeneID" id="41359807"/>
    <dbReference type="KEGG" id="mxa:MXAN_2423"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037203_0_0_7"/>
    <dbReference type="OMA" id="LYVSNWS"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188031" evidence="1">
        <location>
            <begin position="19"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="487" mass="51375" checksum="1A30EB6DC75E45C6" modified="2006-07-11" version="1">MHGGMKRLLALTSTLALATACGNDNPSVPKAECQVEAIDVSACQLSSLSGVQPEGIWNLNINLNDGSGAAAAMRLSGGGSNTQMLMGLAATERQSTPESFFLASEFQGSNNVTMRFAVAGCSSSGPGQMSGIFRRCANGTADMKGTFEAIRLGRRAGEAEASGVELVSEVKLTEATATNVAVAHGHAYVTAGAKGLITFDLSDPSQPRQVRQYELSNDYYTDALVNGNTLYVASRRSGIAVFDITNPAVPVRLRSVPESVVEVNSLALDGNVLYAASPAPNAEVYVYDVATPAEPKQLRRYFVEGAEPRAGEVPLHVAAMGGRLYVSNWSFGMTVSDVTNPASPKLLGRFANGMSAATAVGMVGDRVYAFDAGEDWGAHLSVLDVSAPATVARTGEFRTRPEVSIRSVAFSGTKVYLAYGQDGLRIVDVSVPGSPQQVGYYNTWRETDAGHGVVFLEGLSKVHVPGDGFVYATDSSRGLLIFRETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9X2</accession>
    <name>Q1D9X2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">MXAN_2331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552406.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2331"/>
    <dbReference type="EnsemblBacteria" id="ABF91690">
        <property type="protein sequence ID" value="ABF91690"/>
        <property type="gene ID" value="MXAN_2331"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="11"/>
            <end position="287"/>
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        </location>
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        <location>
            <begin position="112"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="138"/>
        </location>
        <ligand>
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        <location>
            <position position="141"/>
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        </ligand>
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        <location>
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        </location>
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            <end position="257"/>
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        </ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="287" mass="30550" checksum="E87F9DC7A7B85044" modified="2006-07-11" version="1">MTAPHDALPVPSLAPSMEALVSLLTRRSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQHREFLTRPEVRARYWARSLMGWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSRVIELHGALAQVRCLACGAQEAREALQARLLSLNPGFSLEVLELRPDGDADLTSEQLSSFQVPACLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRFLVRASERRMPIAILNLGECRGVELADVHLEARAGDALPRLAAALARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y3</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ABF90762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="27621" checksum="B1DBC470C5054424" modified="2006-07-11" version="1">MLDEESRHRAHLVVSLSGAHAYGFPSPDSDLDLKSIHVAHTAALLTLQPVHVPTERLEVLEGVEVDYSSNELLPVLQGILQGNGNYLERVLGAIPLRVSPELESLRPLVRAVLSRKMYRHYNGFAQGQLREWEKSGFRSAKRLLYVLRTTLTGTHALRTGVVETDVTELLSQYGFVEAHALVEQKLRGEKSELPEALSARWRGEVSRAFEVLEAARADSVLPESPPDEAVAALEAWMLDLRRRRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA99</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">MXAN_2202</name>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ABF90702">
        <property type="protein sequence ID" value="ABF90702"/>
        <property type="gene ID" value="MXAN_2202"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2105309at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="516" mass="58297" checksum="19AEF58513445CB9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAS6</accession>
    <name>Q1DAS6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oligopeptide ABC transporter, periplasmic oligopeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2018"/>
    <dbReference type="EnsemblBacteria" id="ABF91388">
        <property type="protein sequence ID" value="ABF91388"/>
        <property type="gene ID" value="MXAN_2018"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2018"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="37"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="58594" checksum="AFA585E37B207DB3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAW8</accession>
    <name>Q1DAW8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DAW8"/>
    <dbReference type="STRING" id="246197.MXAN_1970"/>
    <dbReference type="EnsemblBacteria" id="ABF91632">
        <property type="protein sequence ID" value="ABF91632"/>
        <property type="gene ID" value="MXAN_1970"/>
    </dbReference>
    <dbReference type="GeneID" id="41359381"/>
    <dbReference type="KEGG" id="mxa:MXAN_1970"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063642_1_0_7"/>
    <dbReference type="OMA" id="SWAREAC"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
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        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF53335"/>
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    </dbReference>
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        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="33083" checksum="C080F01426EBDF68" modified="2006-07-11" version="1">MEELSQSFRVLGDPTRLRILRLVAEAPLNVTELVSLVGVAQSSVSHHLGKLKGLGLLREERHAGYSYYSLALEQADGRWPLIQMARQAEDAAGDSARLKDLLRAREDRQALNERLLEPGQSWFLWAGALASLLPPLEVADFGCGTGVLSVAIARWARRVWAIDQNADALEQARERAGREGLENIRFLREDLHRLSLASGSLDLVVISQSLHHVEEPQSVLSESARLLKPGGRLVLLELMPHEERWVLERLGHRHLGFAPESLEAALREAGFTSLTRETHARDGASPFRVFLLTGVKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY5</accession>
    <name>Q1DAY5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1950"/>
    <dbReference type="EnsemblBacteria" id="ABF90595">
        <property type="protein sequence ID" value="ABF90595"/>
        <property type="gene ID" value="MXAN_1950"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1950"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_7"/>
    <dbReference type="OMA" id="GNYKFLY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="226"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="6">
        <location>
            <begin position="593"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="692" mass="76187" checksum="6DF6DACA5C1CC4BB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ3</accession>
    <name>Q1DAZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MJ0042 family finger-like domain/tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552035.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1942"/>
    <dbReference type="EnsemblBacteria" id="ABF90540">
        <property type="protein sequence ID" value="ABF90540"/>
        <property type="gene ID" value="MXAN_1942"/>
    </dbReference>
    <dbReference type="GeneID" id="41359355"/>
    <dbReference type="KEGG" id="mxa:MXAN_1942"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256427_0_0_7"/>
    <dbReference type="OMA" id="NEPSNHE"/>
    <dbReference type="OrthoDB" id="39475at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1410"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1628" mass="170423" checksum="21AD96F128010D2B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB05</accession>
    <name>Q1DB05_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552024.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1924"/>
    <dbReference type="EnsemblBacteria" id="ABF89029">
        <property type="protein sequence ID" value="ABF89029"/>
        <property type="gene ID" value="MXAN_1924"/>
    </dbReference>
    <dbReference type="GeneID" id="41359338"/>
    <dbReference type="KEGG" id="mxa:MXAN_1924"/>
    <dbReference type="eggNOG" id="ENOG5030CQT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037130_0_0_7"/>
    <dbReference type="OMA" id="HKNEMGG"/>
    <dbReference type="OrthoDB" id="1432735at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188372" evidence="2">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25058" checksum="A8C70CF903DD8E41" modified="2006-07-11" version="1">MRVAATFPLLALLSAALCGPALAQEPAASAPPSAQTAATADEAFDTRVKTLEENVVDLKEKIYRSKARLLLLQETVLGGDVSTGARAVIIHKNEMGGSFELESVAYALDGAPVYTQVDEEGHTDLGKRELFEVFNGRIVPGQHQLAVRLVYRGNGYGVFSYLEGYKFKVQSSYTFSAEPGKTSTVHVVGYEQGGITTDLKDRPAVRYDVSVARESGRKAAPAAPPPVTRSTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL4</accession>
    <name>Q1DBL4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551818.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1708"/>
    <dbReference type="EnsemblBacteria" id="ABF87326">
        <property type="protein sequence ID" value="ABF87326"/>
        <property type="gene ID" value="MXAN_1708"/>
    </dbReference>
    <dbReference type="GeneID" id="41359146"/>
    <dbReference type="KEGG" id="mxa:MXAN_1708"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070791_0_0_7"/>
    <dbReference type="OMA" id="EECKPAP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="36274" checksum="D88B7002E2FA3DC9" modified="2006-07-11" version="1">MPGQRRRQRRLRRFLGRRWATSLFLFDCRGRHASTRAGRTHLGHASCPALQSHARKCPIQRRYPMGSVTAVGGSGAPKVDPAEAQRRAEEARQKAEAARLAAEARRKAATAARDNLTQAKHDAGAARRQKAAAEKTAAAARKAAERPGQTPAEAKKSKEDLAVAEKKLKEVTEASRMAAQKLQDAEEKAALAAKSAEEAMRKANAVAVEESKTPPYSQKDIDKVKPTKNELESAFEGTSRKAELEKLLGLTPPPPQEVIQTVGSGAAPGAPFDAMKTMDAQDVAHGPFGQTHMDSSTDAWFHQRQGSNTGVVPSDATRGNTVPIMPDGSAPSPVTSKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC47</accession>
    <name>GLGC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="1">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgC</name>
        <name type="ordered locus">MXAN_1524</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551635.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DC47"/>
    <dbReference type="SMR" id="Q1DC47"/>
    <dbReference type="STRING" id="246197.MXAN_1524"/>
    <dbReference type="EnsemblBacteria" id="ABF91687">
        <property type="protein sequence ID" value="ABF91687"/>
        <property type="gene ID" value="MXAN_1524"/>
    </dbReference>
    <dbReference type="GeneID" id="41358970"/>
    <dbReference type="KEGG" id="mxa:MXAN_1524"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_7"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000261881" description="Glucose-1-phosphate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <sequence length="409" mass="46095" checksum="5B624852E462D4F5" modified="2006-07-11" version="1">MSKVLAMILAGGAGTRLEPLTRERAKPAVPFGGRYRIIDFVLSNFANSGVYRMKVLTQYKSDSLNNHLSRAWRMTAFLGHYVEAVPAQMRTGLDWYKGSADAIYQNLNIITDEEPDYIFVFGADHVYRMDTRQMLDFHCTKKAACTVAAIPVPIEQGREFGIIDVGPDGRMRQFLEKPKDPPPMPGNPKMCLASMGNYLFSTDVLVQEVVRDAANEASAHDFGKSIISELYKRAPVYVYDFAQNEVPGQEAKERGYWRDVGNIDVYYQSNMDLVEVDPTFNLYNDRWPIHTQPNNYPPAKFVFADEQNHRVGHAMDTLVAEGCIISGGSVRRSVLSPKVRVNSYSEVEDSLLFENVTIGRRCRIRRAIIDKNVEIPPGMTIGFDPVEDRRRFHVTPGGVVVIPKGMKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC73</accession>
    <name>Q1DC73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1498"/>
    <dbReference type="EnsemblBacteria" id="ABF92493">
        <property type="protein sequence ID" value="ABF92493"/>
        <property type="gene ID" value="MXAN_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1498"/>
    <dbReference type="HOGENOM" id="CLU_1106224_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="27774" checksum="56FC6F7CD5B7CA7C" modified="2006-07-11" version="1">MLGGSMATGELLAVKLWNEWGRAIAASRGLTALDLSARVPLIRAKKAVTRVLVSLTSSPQGGLGAELQVRFEKKTPVELEFMGTTYVASKELVVAEGAGTQQGGRVKLASNALKLTLWATGMARIIPSVLEKSPFMGRADRYLRCGRIEQLAYGHDVELGPLREIDGNFTADADEFELLTRLGLTCTDEADSKSTILTHEEWMERRDEDYARMVHTPKIVWRDDDGGRIEPNSSLLNVKWGYRGPKLRTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC80</accession>
    <name>Q1DC80_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551602.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1486"/>
    <dbReference type="EnsemblBacteria" id="ABF87964">
        <property type="protein sequence ID" value="ABF87964"/>
        <property type="gene ID" value="MXAN_1486"/>
    </dbReference>
    <dbReference type="GeneID" id="41358932"/>
    <dbReference type="KEGG" id="mxa:MXAN_1486"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099824_3_0_7"/>
    <dbReference type="OMA" id="QDTWLNT"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="180" mass="21000" checksum="2A7EAF91F66E1674" modified="2006-07-11" version="1">METLVLSQSFEPVARVPWQRAVMLIVQGKVEVVEEYEDRVVRSVTVEIRMPSVIRFIRGLRRRPKGVKFSRENVYLRDHCRCQYCGIKVTRPEATYDHVLPRAQGGKTSWENIVIACVPCNQKKGNRTPEQARMALRTAPMKPKKVPEAMHLTFLFEKGMPMSWAKFLRDVAYWHVELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC2</accession>
    <name>Q1DCC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88199">
        <property type="protein sequence ID" value="ABF88199"/>
        <property type="gene ID" value="MXAN_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1444"/>
    <dbReference type="eggNOG" id="ENOG503408Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426603_0_0_7"/>
    <dbReference type="OMA" id="WYYADAG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="25871" checksum="F138451253EACA8E" modified="2006-07-11" version="1">MGDAMGAEAAVESGDVRQRRQVRIRRADIKRGQRMKVAFAVFRFCLYGMVGLSAEIFFYNLVRIAQHVPLLEALFRFQWRVDDRLGLNAIWDTPISTAYGQCSLWMFVIYGVACFFFIEPLYRWMLYQHTGLRAAVYGVVILLFEGFSGVMLERLTGYRIWYYADAGAILWQMTSLYILPIWMVTGLLAEFIYRELMDPDLLAALESPLPATPEETEASFQLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCD0</accession>
    <name>Q1DCD0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551552.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1436"/>
    <dbReference type="ESTHER" id="myxxd-q1dcd0">
        <property type="family name" value="Abhydr_predicted"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91027">
        <property type="protein sequence ID" value="ABF91027"/>
        <property type="gene ID" value="MXAN_1436"/>
    </dbReference>
    <dbReference type="GeneID" id="41358882"/>
    <dbReference type="KEGG" id="mxa:MXAN_1436"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020280_0_0_7"/>
    <dbReference type="OMA" id="NRRFWYS"/>
    <dbReference type="OrthoDB" id="891360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="67"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="43498" checksum="6B38F4B4BDA084DE" modified="2006-07-11" version="1">MDASRWVVWVLVAGVALVLWNVLWVVAVRRWYRPRAELPQVLRARCEDGWELVIHARRAAVRRFEEPVLLCHGLAANRFTFDFEPPYSVAHYLTEAGFDCFSVEWRGTGHSRRPPRGRRYTDFTIDDHILQDGPALLELALKETGAKCAFWLGHSLGGLVGYGVAQGPHGEKLAGLLALGAPVHFKSEPFLRTLISMGVRAAWPARFRQEWMSASLAPFLGYITLPLSDLLVNPEHIPPRIQRQVYANMMSSMSRKVLLQFQDWIEHDMFRSFDRTKDWRAGIAQLQLPLLVMGGSSDRLATPGNVESQFALATAPDRTLHIFGTDHGDKMNYGHGDLIFGTGAPSEVYPVIREWLERHASALPAAITDPAPAPVEEEPREPERSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS3</accession>
    <name>Q1DCS3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="8">1.3.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemG</name>
        <name evidence="8" type="ORF">MXAN_1293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551410.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DCS3"/>
    <dbReference type="STRING" id="246197.MXAN_1293"/>
    <dbReference type="EnsemblBacteria" id="ABF92067">
        <property type="protein sequence ID" value="ABF92067"/>
        <property type="gene ID" value="MXAN_1293"/>
    </dbReference>
    <dbReference type="GeneID" id="41358739"/>
    <dbReference type="KEGG" id="mxa:MXAN_1293"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_3_0_7"/>
    <dbReference type="OMA" id="WFDQWFG"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="471" mass="49388" checksum="2E9909D464F81515" modified="2006-07-11" version="1">MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQGPNSFLDREPATRALAAALNLEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILPLGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDVEQLSVAATFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAASLGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALAALVAGIAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRVLYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARPSFTRVFRWPLGIPQYNLGHLERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD86</accession>
    <name>Q1DD86_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_1127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551247.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1127"/>
    <dbReference type="EnsemblBacteria" id="ABF91739">
        <property type="protein sequence ID" value="ABF91739"/>
        <property type="gene ID" value="MXAN_1127"/>
    </dbReference>
    <dbReference type="GeneID" id="41358578"/>
    <dbReference type="KEGG" id="mxa:MXAN_1127"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024186_3_1_7"/>
    <dbReference type="OMA" id="TAWLRMD"/>
    <dbReference type="OrthoDB" id="279287at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="9">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="10">
        <location>
            <begin position="311"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="457" mass="49688" checksum="89CAE3253E0C5275" modified="2006-07-11" version="1">MAAQERMSSVDALWFHMEEPANLMMITAVLWFEGRLDFERLRTVVRERLVERYPRFRQRAVAGLVGLPQWEEVAELDLDWHLSRLDVPPPGDRAALESLVGEWMSTPLERSRPLWQFHVMSAADGRDVLLARLHHCLADGMALARVLLTLTDGAEAEMAAEAPEPTSRPSTGGLASWVRGARAVAGTARAVWRKGAELAAEPILVGDLLVQGARGAAAMGKLLVIPPDPRTSLRGPLGTQKRAAWSDPVPLERVKAVGRALGGTVNDVLLAAVAGALRRYLESLGEPPEDLHALVPVNLRPLDVPVPRELGNHFGVVFLRLPVQLGTPQRRLQELVRRMERLKRSPEAVLTFGALELLGYTPAALERWVVDTFGSKASLIATNVPGPRAAVSLAGSRLEGLTFWVPQTGHLGLGVSLFSYAGQVTVGVAADAGRVTDPHALIQAFHEELDALATERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE4</accession>
    <name>Q1DDE4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1069"/>
    <dbReference type="EnsemblBacteria" id="ABF87162">
        <property type="protein sequence ID" value="ABF87162"/>
        <property type="gene ID" value="MXAN_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1069"/>
    <dbReference type="HOGENOM" id="CLU_3397537_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="31" mass="3385" checksum="D9A9B86886117DB5" modified="2006-07-11" version="1">MPLCGTGQKTGKGEWLRESTSGRSLFQQAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDK2</accession>
    <name>Q1DDK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminoglutamate deiminase</fullName>
            <ecNumber evidence="2">3.5.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hutF</name>
        <name evidence="2" type="ORF">MXAN_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.3.13" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551131.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1010"/>
    <dbReference type="EnsemblBacteria" id="ABF90129">
        <property type="protein sequence ID" value="ABF90129"/>
        <property type="gene ID" value="MXAN_1010"/>
    </dbReference>
    <dbReference type="GeneID" id="41358465"/>
    <dbReference type="KEGG" id="mxa:MXAN_1010"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_3_1_7"/>
    <dbReference type="OMA" id="MCPTTER"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050416">
        <property type="term" value="F:formimidoylglutamate deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="462" mass="48984" checksum="C8B698D4E73C6D59" modified="2006-07-11" version="1">MSDITVYQPELLYTGGRFHEGRGLAVSADGRILAPECVPAGARTVALPGRALLPGLVNGHSHAFQRLIRGRTEYVASGREADDFWSWREAMYRAAESLSPEDLYVASRQAFVEMALAGITTVGEFHYVHHQSDGTPYADRNTLAHAVIRAARDVGLRICLLRVGYARAGFGVAANPRQRRFIDPDVETFLGSVEALAREVRADAAVSVGLAPHSVRAVPREWLAALASASVRSLPVHMHVAEQPKEIEACLAEHGRRPVELLADLGLLGPGFTAVHGVHLTDEEVSLLGRAEATVCACPSTERNLGDGIVPADALVTAGARISLGSDSQATVDLLDEARQLEGHLRLSRLRRAVLDPGGGAMDGLAARLLDMATVDGARSLGLATGALEAGAPADFFTVDLHHPSLVGALPASLLPAIVLGAEKAAVRDVVVGGREVVREGRHALAEESGRAFQVLSRALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDQ4</accession>
    <name>Q1DDQ4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">sbcD</name>
        <name evidence="10" type="ORF">MXAN_0958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551079.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0958"/>
    <dbReference type="EnsemblBacteria" id="ABF88398">
        <property type="protein sequence ID" value="ABF88398"/>
        <property type="gene ID" value="MXAN_0958"/>
    </dbReference>
    <dbReference type="GeneID" id="41358417"/>
    <dbReference type="KEGG" id="mxa:MXAN_0958"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038045_2_1_7"/>
    <dbReference type="OMA" id="TSGNHDS"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="283"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="414" mass="45132" checksum="5048A4C6F4411E8F" modified="2006-07-11" version="1">MRLLHTSDWHLGHTLYDVSRDAEHAAFLDWLLETLEAQSVDALLVAGDIFDTANPSAEAQAAWYQFVAKARRRMPRLDVVVIGGNHDSAARLDAPDPLFAALGVHVVGGLPRARGAMDQERLLVPLHDAKGRVGAWVAAVPYLRPADLPPVPGDMGDRLVEGVRSVYAEVLAAARRRRQAGQALVAMGHCYMTGTELSALSERKILGGNQHALPVDLFPDDVAYAALGHLHKAQRVGGREGVRYSGSPLPLSLSEAGYRHQVLLVELEGDALREVQSLPVPRTTDMVRVPSRDAAPLDAVLTQLEGLPAHDADTLEWRRPYLEVCVSLPRPEPALRQKVEKVLEGKAARLVKLTPAYTGTGGALAEVQPGLSLKERTPEDVFRARYARDFEEPPALALLEAFHTLLTDVQEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDQ9</accession>
    <name>Q1DDQ9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">zwf</name>
        <name evidence="10" type="ORF">MXAN_0953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551074.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0953"/>
    <dbReference type="EnsemblBacteria" id="ABF90188">
        <property type="protein sequence ID" value="ABF90188"/>
        <property type="gene ID" value="MXAN_0953"/>
    </dbReference>
    <dbReference type="GeneID" id="41358412"/>
    <dbReference type="KEGG" id="mxa:MXAN_0953"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_7"/>
    <dbReference type="OMA" id="PDEGIQM"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
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            <end position="219"/>
        </location>
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            <end position="511"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="binding site" evidence="5">
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            <position position="68"/>
        </location>
        <ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90188.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="514" mass="57591" checksum="FA2E54B77281EA46" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB1</accession>
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        </submittedName>
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    </gene>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="34"/>
        </location>
    </feature>
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            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    <sequence length="364" mass="36945" checksum="704A504F5FF80BB4" modified="2006-07-11" version="1">MLVPLRLRLAPGLAVALAVPITVFVWCFTLGPLLEGMAGVSHAFQAAGPFAALVAMALALEVPLLSLALVGSGMDRRVPLSAMLGLATLPWMLGLMGTEVLMDRVLASLPRLDTVEAGLVLATSTGEAMAPRLLGAWTSTALLLGLALGLALAHFGPTGFREPAGSRNRGLLLASGVSASLASVAMVGALEARHLLSFLTSLARMPDAERSELIATGLAATANLRALRWTCTGVLAVLGLTLMARRAGEDSHSPLGWSARLVPATAVAVLLVLDAHPVSSATEHAPVAIPAEHGESPSGSMPQPPSGDVSPAQPIKMNASIPNPTSNPRASTSSIVTPSPRRTTGGVTSSTTATAAGGTSKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
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            <end position="96"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="357" mass="39155" checksum="033CE099CBC6FA9E" modified="2006-07-11" version="1">MRHGGSVMADIADGEQVSVQGSGSKPYILKNTGGVYSCSCPAWRNQSVAIERRTCKHLRRVRGDAAEDARIGGDGSGAPAVPARPTRSTSASDDTKAPPLLLAQSWENDVDLTGWWMSEKLDGVRAYWDGKQFWSRLGNAFLAPEWFTAGLPDFPLDGELFGGRKRFQRTVSIVRRQDRSDDWKELAFVAFDAPGVEGTFEARLERCRQWMEEAKPAYAQWHAHARCDGTPHLRTELARVESLGGEGLMLRQPGSRYEAGRSHTLLKVKSFKDDEARVVGHVAGAGRHKGRLGALEVELRNGTRFSVGTGLSDAERASPPPVGAIITFRYQELSNDGVPRFPSYVGVRVDAAPFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEV6</accession>
    <name>Q1DEV6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550680.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0548"/>
    <dbReference type="EnsemblBacteria" id="ABF87956">
        <property type="protein sequence ID" value="ABF87956"/>
        <property type="gene ID" value="MXAN_0548"/>
    </dbReference>
    <dbReference type="GeneID" id="41358032"/>
    <dbReference type="KEGG" id="mxa:MXAN_0548"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_4_7"/>
    <dbReference type="OMA" id="NPHPEGK"/>
    <dbReference type="OrthoDB" id="1383885at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="21317" checksum="A9A6D2BB684C8C8E" modified="2006-07-11" version="1">MKLYFNPRSRAVIAKWMLDECGAQYEIVPIDFEKKENKSPEFLKINPAGKLPALVDGDTRLFESAAICLYLAEKFPDAQLAPKPGDKDWGRYLSLMVYSTSQLEPSMGDHLMKLPTGPARGWTDFETVLNVVEGELGQGPYLFGERFTAADVMVGSMFIWMRIFGSQTGRPALEAYIERLLARPKGMKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF84</accession>
    <name>Q1DF84_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550552.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0418"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85982">
        <property type="protein sequence ID" value="ABF85982"/>
        <property type="gene ID" value="MXAN_0418"/>
    </dbReference>
    <dbReference type="GeneID" id="41357912"/>
    <dbReference type="KEGG" id="mxa:MXAN_0418"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1179198_0_0_7"/>
    <dbReference type="OMA" id="NNVNCAN"/>
    <dbReference type="OrthoDB" id="1348181at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="30591" checksum="FCDFEDDABFABA958" modified="2006-07-11" version="1">MKCFSTHLPENSLESRGVPGAGLENQEARNSGSQAPRIGARRTCGALAPLQTPTEPPMSSSYRIKSGDTLSHLAQRYNTSVSALMKANPQIKNADLIYAGKSLNIPGSKDSFESGSAGRAGGATGGGGSSGGAQDVQGPSSSGPGVRGPKGSPFEIASQHLGKNAGSLKLEKNGVGADMEDWVPNNVNCANFVSAVLEQSGQISDSQHDNSVMGLMAKLDRDPKFKRIDLKDAKPGDVVSMKTNGGQHVVMFAGWKDGKPTFIGSNNVNSDGSQRVTISSMNYPIMAVHQYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK5</accession>
    <name>Q1DFK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550432.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0288"/>
    <dbReference type="EnsemblBacteria" id="ABF90600">
        <property type="protein sequence ID" value="ABF90600"/>
        <property type="gene ID" value="MXAN_0288"/>
    </dbReference>
    <dbReference type="GeneID" id="41357787"/>
    <dbReference type="KEGG" id="mxa:MXAN_0288"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615124_0_0_7"/>
    <dbReference type="OMA" id="RAPVAIN"/>
    <dbReference type="OrthoDB" id="401848at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="66"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="445" mass="47739" checksum="5718ABB073EAD565" modified="2006-07-11" version="1">MAHETSGIGGGPLPQIDSRHNASCDHGGVRMKQTAWAVERDAEHGREVLLLVTLEADADAPRAPVAINLALDRSASMRGVPLLAAVQAAQALVERASPRDYLGLLTFDAEPEQVLPMRAMDPNARAQLLKVLARLESGEGTALHEAVERASESARRVLVPGARPQVLMLTDGEPSVGPSQLAEFKTQGARIAESGVMLHALGLGRHYLPDILEALTSPSGTGFVHVDDPEGLPMAVGQLGAELFGEVVADARVHVLPTGFADVRCRHRYPSRVEGDAMSATLGAISQAFPRRVLFSGMLGDAEWNLGVSTSYSERGDTRRISVPVTRVLPDSDAGRFVRAVSAELDLVAGEAAAWKALGRRHQDAAERALEAADVALYKLARLGSAEVPAQRHVERLADLRRVIERRANKLPALVMRRAHSEVSRITMSRVGPAAPALLPWKTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFQ9</accession>
    <name>Q1DFQ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">B12 binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550378.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0232"/>
    <dbReference type="EnsemblBacteria" id="ABF90394">
        <property type="protein sequence ID" value="ABF90394"/>
        <property type="gene ID" value="MXAN_0232"/>
    </dbReference>
    <dbReference type="GeneID" id="41357732"/>
    <dbReference type="KEGG" id="mxa:MXAN_0232"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064060_1_1_7"/>
    <dbReference type="OMA" id="LWEEDAC"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="97"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="24127" checksum="5C0947CD74520192" modified="2006-07-11" version="1">MLTSHDSALTGLLNAYLAAQLAGNRREALRLLVDEGLLRDIPLQTLHLEVIQPAQYEIGRLWQENVISVAQEHLATAVSQLALAHLYRHLPRDPFNGKVVLVSCVQGELHEVGARMSSDFLEMAGFDVRFLGANVPPEHLARMTNELRPDLVALSVTMTYHLPALREAVAHVRKTLPDVPIAVGGLAFNWAPGLEEELGVNFFGKDARQFVASACRALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR9</accession>
    <name>Q1DFR9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF87627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0222"/>
    <dbReference type="EnsemblBacteria" id="ABF87627">
        <property type="protein sequence ID" value="ABF87627"/>
        <property type="gene ID" value="MXAN_0222"/>
    </dbReference>
    <dbReference type="GeneID" id="41357723"/>
    <dbReference type="KEGG" id="mxa:MXAN_0222"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_7"/>
    <dbReference type="OMA" id="VWYLLHK"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="37096" checksum="50DCFEEF43B7FFD2" modified="2006-07-11" version="1">MRARKVVIRKAGGYEQLHLEEVNQDSPGIGEVRVATEAIGVNYADCVIRMGLYASAKEYVGWPITPGFEFAGHVDAVGPGVEDLAPGARVFGVTRFGGYATHVTVPRHQVFTLPARLSMEQAAGFPTVFLTAYYALFELAHPRPGANVLVHSAAGGVGGALLQLGRIAGCRMVGVVGGTHKVETARAQGAEVVIDKSREDLWSVAKKAAPRGYDVVLDANGPSTLRDSYKHLASPGKLVIYGFHSMLPRTGGRPNYAKLAWDWLRTPRFDPLTLTNDNTSVLAFNLSYLFEQRAVLEESMAQLLGWLEEGKLVPPPVKSFPLDAVADAHRALESGGTVGKLVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFW4</accession>
    <name>Q1DFW4_MYXXD</name>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550323.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0176"/>
    <dbReference type="EnsemblBacteria" id="ABF92027">
        <property type="protein sequence ID" value="ABF92027"/>
        <property type="gene ID" value="MXAN_0176"/>
    </dbReference>
    <dbReference type="GeneID" id="41357679"/>
    <dbReference type="KEGG" id="mxa:MXAN_0176"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_7"/>
    <dbReference type="OMA" id="PSACIQF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="425"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="642" mass="69803" checksum="B9F0946876A8D2C3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFZ9</accession>
    <name>Q1DFZ9_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">SWIM zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0141"/>
    <dbReference type="EnsemblBacteria" id="ABF86122">
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        <property type="gene ID" value="MXAN_0141"/>
    </dbReference>
    <dbReference type="GeneID" id="41357644"/>
    <dbReference type="KEGG" id="mxa:MXAN_0141"/>
    <dbReference type="eggNOG" id="COG4715">
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    <dbReference type="OMA" id="HRELPYD"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="617" mass="67541" checksum="107897C906FBCEF0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVI5</accession>
    <name>Q1CVI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92810">
        <property type="protein sequence ID" value="ABF92810"/>
        <property type="gene ID" value="MXAN_7485"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7485"/>
    <dbReference type="HOGENOM" id="CLU_2012811_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="123" mass="14333" checksum="568A77C05E828D41" modified="2006-07-11" version="1">MLVRGCTKWVRLAHARCQPWFHVEQGRAKPRGRVERVRFIHARWPPRFHVVEEEVLVRGCAKWVRLAHARCLPWFHVEHGDTAQARGRAERVRLVHAENADVLARGCAERVRLAHARCPLPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVI6</accession>
    <name>Q1CVI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87321">
        <property type="protein sequence ID" value="ABF87321"/>
        <property type="gene ID" value="MXAN_7484"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7484"/>
    <dbReference type="HOGENOM" id="CLU_2718146_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="72" mass="8546" checksum="D56FFBA74F02E85C" modified="2006-07-11" version="1">MTKLLHDPRVRARALPTFHVELAMHRAHARVHATRSRSTWNKQRASHACETANASMNWEPKKWRTTWLHPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVP2</accession>
    <name>Q1CVP2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2379 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557336.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7425"/>
    <dbReference type="EnsemblBacteria" id="ABF90861">
        <property type="protein sequence ID" value="ABF90861"/>
        <property type="gene ID" value="MXAN_7425"/>
    </dbReference>
    <dbReference type="GeneID" id="41364580"/>
    <dbReference type="KEGG" id="mxa:MXAN_7425"/>
    <dbReference type="HOGENOM" id="CLU_161985_0_0_7"/>
    <dbReference type="OrthoDB" id="1942690at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011753">
        <property type="entry name" value="DUSAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09543">
        <property type="entry name" value="DUF2379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02267">
        <property type="entry name" value="TIGR02267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2379" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="14130" checksum="BD631F9773994678" modified="2006-07-11" version="1">MDDSPDWDPVRALAHGVLNQGIPLELTDDVRSLLRRTAREVAISDADTALQTQAGATELLREAMRRIKDGSWRLMRALHRMYQHKRAGDFDSARQEMREVLAEEVVPFYRDVAAGQLEDLDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVR4</accession>
    <name>Q1CVR4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557314.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7402"/>
    <dbReference type="EnsemblBacteria" id="ABF87730">
        <property type="protein sequence ID" value="ABF87730"/>
        <property type="gene ID" value="MXAN_7402"/>
    </dbReference>
    <dbReference type="GeneID" id="41364560"/>
    <dbReference type="KEGG" id="mxa:MXAN_7402"/>
    <dbReference type="eggNOG" id="COG5592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_6_2_7"/>
    <dbReference type="OMA" id="EERCLYP"/>
    <dbReference type="OrthoDB" id="1927478at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="21026" checksum="96DE9EBF11EBF0B5" modified="2006-07-11" version="1">MSARRHTQVVCFLVHAECSGMGSPFDILIDQHRELEERLERLASGVEPDELRGLTAELLALLRLHSRLEERCLYPVMAGVEGRESCREQTEDHLTMRELMAELEELPSGHPEWQARLLTLEDLAVAHFQEEENARLPQLMTALDSLSLGDLRRDLSATWDELLSRPQVSQVAGEAPLLESLYWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVY9</accession>
    <name>Q1CVY9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AfsR/DnrI/RedD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557240.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7321"/>
    <dbReference type="EnsemblBacteria" id="ABF86393">
        <property type="protein sequence ID" value="ABF86393"/>
        <property type="gene ID" value="MXAN_7321"/>
    </dbReference>
    <dbReference type="GeneID" id="41364484"/>
    <dbReference type="KEGG" id="mxa:MXAN_7321"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004435_1_1_7"/>
    <dbReference type="OMA" id="THARTFR"/>
    <dbReference type="OrthoDB" id="435185at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="690" mass="75928" checksum="8C4BC2A6A84FAA58" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW16</accession>
    <name>Q1CW16_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557213.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7294"/>
    <dbReference type="EnsemblBacteria" id="ABF88896">
        <property type="protein sequence ID" value="ABF88896"/>
        <property type="gene ID" value="MXAN_7294"/>
    </dbReference>
    <dbReference type="GeneID" id="41364457"/>
    <dbReference type="KEGG" id="mxa:MXAN_7294"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_7"/>
    <dbReference type="OMA" id="FMIVVTQ"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="32011" checksum="E6A36AFDFB00D828" modified="2006-07-11" version="1">MNPRGSLARERRQAYLLVAPAVLVLGGVALYPILAAVWLSLHRFILVFGERRFTGLENYAYLLGDSRFWAALGNTAYFTAVAVTVELLLAVPLALLLQKSFPGRGLLRASVLVPWAIPTVVSARLWAWMFNPEYGVINRLLPGQDINWLGAPGYALHAAILVDVWKTTPFVALLVLAGLQGISEDLYKAARVDGASPWRTFVSITLPLLKPALLLALLFRSLDAFRVFDAIYVLTEGGPANTTETLSIYAYKTLMRSGDFGYGSTLSVATFLCVVLLAAVWLRLLGREEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH8</accession>
    <name>Q1CWH8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7132"/>
    <dbReference type="EnsemblBacteria" id="ABF88439">
        <property type="protein sequence ID" value="ABF88439"/>
        <property type="gene ID" value="MXAN_7132"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7132"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045796_0_0_7"/>
    <dbReference type="OMA" id="YGKARSY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="35"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="38556" checksum="C514761DC18563C3" modified="2006-07-11" version="1">MAICPDRHEHFMGHPTIENETPFAFDMMGLADEDGRPLLLLVVKATYDFGTSGLKLAGEQLPVTWGGESWGKPGESSDKYEPESAFIKLATDVALIGHAYPPQKGATEALVALQVGPLKKAVRVVGERTWFKSMGHVAATKPLPFDKIPLTWERAFGGWDRTDTVKPAFEPRNPVGVGFRASPRHFEEGLKLPNLEDPATEPLRDFGQKVVPAGFGFTSPHWQPRARYGGTYDESWNKSRKPLLPKDFDRRFFNAAAPGLIAPGYLKGDEPVIIAGASPKGRLSFALPGQAAPIVTVALAGGEDATPPMHLDTVTLDTDEEKVTLLWRGHVALGEGLHDVRGLKVTAQGVTAPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWP7</accession>
    <name>Q1CWP7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7063"/>
    <dbReference type="EnsemblBacteria" id="ABF92501">
        <property type="protein sequence ID" value="ABF92501"/>
        <property type="gene ID" value="MXAN_7063"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7063"/>
    <dbReference type="HOGENOM" id="CLU_117657_1_1_7"/>
    <dbReference type="OMA" id="ESCPFFA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025361">
        <property type="entry name" value="DUF4265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14085">
        <property type="entry name" value="DUF4265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="110" mass="12191" checksum="A2F053EC64788484" modified="2006-07-11" version="1">MFQLDNVPFFAKGVACEDVVSAKDVDGELRFQKVVRPSGHATLRLIVHDEEDVPSVKELLEKHGCAVERSHVPGLISVDVPPTVPLDSLKPLLDEGEDEERWGYEEACLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWZ4</accession>
    <name>Q1CWZ4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6964"/>
    <dbReference type="EnsemblBacteria" id="ABF92123">
        <property type="protein sequence ID" value="ABF92123"/>
        <property type="gene ID" value="MXAN_6964"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6964"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_7"/>
    <dbReference type="OMA" id="WMETCLR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
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        <location>
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            <end position="111"/>
        </location>
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            <end position="526"/>
        </location>
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            <end position="666"/>
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    </feature>
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            <begin position="261"/>
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        </location>
    </feature>
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        <location>
            <position position="50"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="683" mass="71839" checksum="E351740E872FFA72" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Major facilitator family transporter</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_6841"/>
    <dbReference type="eggNOG" id="COG0477">
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="438" mass="46149" checksum="FBCE1BD70D5E7B3A" modified="2006-07-11" version="1">MSSLPASQDLPQRPLTRDDARTLTLAALGGALEFYDFIIFVFFTKVIGELFFPPDTPEWLRQLQAFGLFAAGYLARPLGGIVMAHFGDRAGRKRMFTLSVFMMSVPTLLIGLLPTYETAGYAAPLALLLLRAVQGAAVGGEVPGAWVFVSEHVPTRRVGLACGTLTAGLTFGILLGSLVATAVNSLLGPEQVNAYGWRAPFLIGGVFGFLAVFLRRWLAETPVFEELRRRKALVRELPLKAVLRGHGGTVVMSMLLTWVLTAGIVVVILMTPTLMQTLHAITATQALVASSVATLSLTFGCVAYGLLADRVGVGPSLGLGCALMLSATYALYLGASSPEALVPLSALAGFCVGVVGVVPTSIVRAFPAAVRFSGLSFSYNMAYAIFGGLTPLVVTLMMKASPLAPAHYVAAVSVMGVGIALHLLRAGRGAALHPATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXE9</accession>
    <name>Q1CXE9_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88528">
        <property type="protein sequence ID" value="ABF88528"/>
        <property type="gene ID" value="MXAN_6807"/>
    </dbReference>
    <dbReference type="GeneID" id="41363996"/>
    <dbReference type="KEGG" id="mxa:MXAN_6807"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="556" mass="59349" checksum="32AE07702CD1EE76" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXR9</accession>
    <name>Q1CXR9_MYXXD</name>
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        <submittedName>
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    </protein>
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    </gene>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
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        </location>
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        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6311" evidence="3">
        <location>
            <begin position="50"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="588" mass="63779" checksum="420BCE6E1BC52BAF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW3</accession>
    <name>Q1CXW3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdate ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">modC</name>
        <name evidence="6" type="ORF">MXAN_6643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.29" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556568.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6643"/>
    <dbReference type="EnsemblBacteria" id="ABF91211">
        <property type="protein sequence ID" value="ABF91211"/>
        <property type="gene ID" value="MXAN_6643"/>
    </dbReference>
    <dbReference type="GeneID" id="41363839"/>
    <dbReference type="KEGG" id="mxa:MXAN_6643"/>
    <dbReference type="eggNOG" id="COG4148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="QWLYAQI"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011868">
        <property type="entry name" value="ModC_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02142">
        <property type="entry name" value="modC_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="37829" checksum="61D6E73A35BB3369" modified="2006-07-11" version="1">MSLELDIRLPLARFTLEVGTRLDGASVAVMGRSGSGKTSLLEVLAGLRRGARGRVVLDGRVLLDSVARSDVPPEQRRMGYVPQDALLFPHLTAEQNVRYGVRPGRASRVDEAVEILELAPLLRRYPATLSGGEKQRVALARALATDPALLLLDEPLAALDVALKERVLPYLLRVRDEARVPMLYVTHQLGEARVLAREALLLDQGQVRAAGPAAEVLGAAARGLLAGEGDGEENILEGVLERPDDGGLRLRMQGGLSLWVPDSPALAPGTRAAYAVPAADILLSIQPLTGVSARNVMTGTVVNVESVATGEDAATVDVAGVRWVVWLTSASVRELGVVPGARVSLAVKTSACRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYB1</accession>
    <name>Q1CYB1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556420.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6490"/>
    <dbReference type="EnsemblBacteria" id="ABF88756">
        <property type="protein sequence ID" value="ABF88756"/>
        <property type="gene ID" value="MXAN_6490"/>
    </dbReference>
    <dbReference type="GeneID" id="41363697"/>
    <dbReference type="KEGG" id="mxa:MXAN_6490"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054137_1_2_7"/>
    <dbReference type="OMA" id="NVLQFVW"/>
    <dbReference type="OrthoDB" id="856351at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="2">
        <location>
            <begin position="145"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="37977" checksum="877E6657B7957481" modified="2006-07-11" version="1">MTLGVGSMRAQYKSTTIPAWNGLRVTRGELEGRAAPVPLGYAPAPVATSSAPRRRPHVFAVLLAVAALLGAGGALHVQGLLPARVPSPATPFSYHDYEKVLRHVRPDGDVDFASVGRERKTLDGFVDSLASFSPHNRPDVFPTPEDALAYWLNAYNALVLQQVVDGYPYLETVQQPLLGRFFWGRSWALGGERLTLWALHNRVLRREFADPRIHLALFQAARGGPRLDGSHFQPEFLDSQLNEAGRRFVGDRRNVRLERDTVYLTSLFEEYREDFLAALPEGRGGNVLQFVWAFLPDTCEERPGCDTRSDLDRACGPRLDQCRIAFMERDWTLPDAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYR8</accession>
    <name>Q1CYR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556263.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6330"/>
    <dbReference type="EnsemblBacteria" id="ABF90290">
        <property type="protein sequence ID" value="ABF90290"/>
        <property type="gene ID" value="MXAN_6330"/>
    </dbReference>
    <dbReference type="GeneID" id="41363545"/>
    <dbReference type="KEGG" id="mxa:MXAN_6330"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OrthoDB" id="1412466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187910" evidence="2">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="24872" checksum="F403D7664252790F" modified="2006-07-11" version="1">MRTLLSLWLLLLTAPWAGCASAPQASTQQAWNGAEEACATPDEDQCVSLLCMGDACGFYRCQDLDGAVEFARFPPARPPAAVAAPGRGPRRNRGGGQHLPRGAVMVFPNWNGAPERFFSAPPRLTPGRWEKHHIFPQAEDLARWFERQGVKIHDYTMPIPRHVHQRIHRGGEGGGEWNRAWREFKDANEGATPTEIFRHAGELIHRFELMGGPIQPYYSRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ35</accession>
    <name>Q1CZ35_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86470">
        <property type="protein sequence ID" value="ABF86470"/>
        <property type="gene ID" value="MXAN_6207"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6207"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060321_0_0_7"/>
    <dbReference type="OMA" id="SNHMLDT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="35175" checksum="0FB44CCE3961B78B" modified="2006-07-11" version="1">MRRWGEHPSPTGQEALVSPIDRSRSAVTPTTVKAPTAAPKNSLVGGVVDAIKGGIADVPRFIEMGKDVFQAAHVNELKRIFGGDAKPDRMNDGKFVGAKGQTFPPGTPLKEIPGVTPLDNPNPSKTILYVNGIMTPTSGQLSEMQAIAETADAKVVGIHNATQGLVADLAQCVADKLDKGHNPAVDALADTLYSELKAGREVHLMGYSQGGLITARALDDVAKRLRIEDGMSQAQVEKTLGKLSVETFGAASTRYVDGPKYVHYVNNADPVPTLTGLGGSVDPTAFLKDAGKGAVVHRFTDGNANPISNHMLDTLYMKHRVDFDQARAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZF4</accession>
    <name>Q1CZF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556033.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6084"/>
    <dbReference type="EnsemblBacteria" id="ABF89236">
        <property type="protein sequence ID" value="ABF89236"/>
        <property type="gene ID" value="MXAN_6084"/>
    </dbReference>
    <dbReference type="GeneID" id="41363320"/>
    <dbReference type="KEGG" id="mxa:MXAN_6084"/>
    <dbReference type="HOGENOM" id="CLU_1756890_0_0_7"/>
    <dbReference type="OMA" id="SYGWVDR"/>
    <dbReference type="OrthoDB" id="1684669at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="16594" checksum="6552982813C9EEBB" modified="2006-07-11" version="1">MKKTQVELESRVIVGAHGVAAEEDHLVMGKVVGVGVGALAIFAVGIVWAYTIQVRTMADIQPEGPPPRPAAMGQYEVGIVNQRLFEQDWHAVDKISGQDQALRAGWGNEPGVKQHPGIDDAMKTVIEQKRNPPPAPTPTPTPETTPGQTPPAPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZF8</accession>
    <name>Q1CZF8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoredutase membrane subunit, NrfD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556029.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6080"/>
    <dbReference type="EnsemblBacteria" id="ABF92509">
        <property type="protein sequence ID" value="ABF92509"/>
        <property type="gene ID" value="MXAN_6080"/>
    </dbReference>
    <dbReference type="GeneID" id="41363316"/>
    <dbReference type="KEGG" id="mxa:MXAN_6080"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_7"/>
    <dbReference type="OMA" id="WWVGIGH"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="479" mass="53860" checksum="A2B6720CA66F87C6" modified="2006-07-11" version="1">MAETASTTYHDPLEPRPLVAPHHDDATLNETLLDHVWRKPGKGWFMLFGLSLSALGLLVIGVTYTLARGIGVWGNNQPVGWAFDIINFVWWVGIGHAGTLISAILLLFQQKWRTSINRFAEAMTLFAVMCAGLFPLLHTGRPWFAFWLFPYPSTLGAWPQFRSPLVWDVFAISTYLTVSALFWFVGLIPDLAALRDSSKTKLQRTIYGLFALGWRGSGRHWHNYKIAYLLLAGLSTPLVVSVHTIVSFDFAVSLLPGWHATIFPPYFVAGAVFSGFAMVITLIIPARKYLGLRDVITDRHLENMNKVILATGLLVSYGYLMEHFVAWYSQNQYELWTFYVNRATGPYAGVYWLMIACNVITPNIFWFKKCRTNIAIMWVASIAVNIGMWCERFIIIVTSLSQDFLPSSWGIYTPTWVDWSIYIGTLGLFGTLFLLFLKFVPAVAISEVKELQLELKHAAHQHGSDDALAGAGTLTHGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D091</accession>
    <name>Q1D091_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555746.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5795"/>
    <dbReference type="EnsemblBacteria" id="ABF88070">
        <property type="protein sequence ID" value="ABF88070"/>
        <property type="gene ID" value="MXAN_5795"/>
    </dbReference>
    <dbReference type="GeneID" id="41363038"/>
    <dbReference type="KEGG" id="mxa:MXAN_5795"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_1_0_7"/>
    <dbReference type="OMA" id="PRRAQNY"/>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="284"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="988" mass="107669" checksum="ECDCF633CA40075B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0E4</accession>
    <name>Q1D0E4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555693.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5742"/>
    <dbReference type="EnsemblBacteria" id="ABF90112">
        <property type="protein sequence ID" value="ABF90112"/>
        <property type="gene ID" value="MXAN_5742"/>
    </dbReference>
    <dbReference type="GeneID" id="41362985"/>
    <dbReference type="KEGG" id="mxa:MXAN_5742"/>
    <dbReference type="HOGENOM" id="CLU_167543_0_0_7"/>
    <dbReference type="OMA" id="DEEGQPC"/>
    <dbReference type="OrthoDB" id="2044274at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187766" evidence="2">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="117" mass="11839" checksum="EEA76268F17CEB00" modified="2006-07-11" version="1">MRRPLRNLVAFMALSTGLSACSLLVDFDEEGQPCDELNQCLEGYTCVDNACAPDDGAPSDGGSDAGTDGGLNTDGGLTTDSGTLDPDAGSEELDAGLPDDAGTTEPGPVLEPEFPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H5</accession>
    <name>Q1D0H5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pdp</name>
        <name evidence="10" type="ORF">MXAN_5710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555662.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5710"/>
    <dbReference type="EnsemblBacteria" id="ABF91657">
        <property type="protein sequence ID" value="ABF91657"/>
        <property type="gene ID" value="MXAN_5710"/>
    </dbReference>
    <dbReference type="GeneID" id="41362955"/>
    <dbReference type="KEGG" id="mxa:MXAN_5710"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_7"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="9">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="434" mass="46343" checksum="B60F98ADA332279D" modified="2006-07-11" version="1">MQPYELIKAKRDGGRLEPADIRAFIEAYTAGTVADYQMAAMCMAIFFRGMDSRELGAWARAMLESGEVLDLSDTPGVKVDKHSTGGVGDKVSLSLAPLAAACGVPVPMISGRGLGHTGGTLDKLESIPGFNVNLPTSEYRRLVREVNCCLIGQTAQVAPADKKLYALRDVTATVDCIPLIASSIMSKKLAEGIDALVLDVKVGSGAFMKRDEDARTLAKTMIGLGAEMGKKVVALLTDMDQPLGRKVGNALEVIEAVDMLRGNAPEDYTEVTYALTAEMLVLGKKAATVEEAREKLRKVVEDGSAVRKLKEIVQVQGGDPRSIDDYSLLPQAKATVDVVAPRDGFVTGIDTEGVGMAAVALGAGRQRTDSKIDPAVGFTLLKKSGESVKQGEPVVRVHYNDAAQLENVKARLLAAYRFGDVAPVARPLIRERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K9</accession>
    <name>Q1D0K9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0W2</accession>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5004188136" evidence="2">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="3">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="3">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="22767" checksum="CE2B219531517E60" modified="2006-07-11" version="1">MKDASTRFSCRALTAAWMGPLAALSLAGCSGPVNNQQGYMPEQPVAFSHAVHAGQYGLDCQYCHVGAEKSRHAGVPSTSVCMNCHTQVKTDSPEIQKVAAAVAENKPLAWVRIHRLPDHAYFNHASHVGAGLDCQTCHGPVQEMVRVEQKEPMTMGWCLDCHRDTAAKQVSAPPPSAPRAGELLALSSGAPAPEPLKAPRILQPPTDCSSCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Z7</accession>
    <name>Q1D0Z7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555491.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5535"/>
    <dbReference type="EnsemblBacteria" id="ABF87139">
        <property type="protein sequence ID" value="ABF87139"/>
        <property type="gene ID" value="MXAN_5535"/>
    </dbReference>
    <dbReference type="GeneID" id="41364764"/>
    <dbReference type="KEGG" id="mxa:MXAN_5535"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033235_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="225"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="646" mass="72806" checksum="AA9286489AE343B1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D128</accession>
    <name>Q1D128_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555460.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5502"/>
    <dbReference type="EnsemblBacteria" id="ABF90546">
        <property type="protein sequence ID" value="ABF90546"/>
        <property type="gene ID" value="MXAN_5502"/>
    </dbReference>
    <dbReference type="GeneID" id="41362756"/>
    <dbReference type="KEGG" id="mxa:MXAN_5502"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="CSQIGMV"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27512" checksum="E479582881EB2ED2" modified="2006-07-11" version="1">MIEVEKLSKRYEGRPVLEGINAVFSPGEVTALVGPSGGGKSTLLRCLNGLESFDGGLVRVGPDTLAPGDVRAQGEKVRRIRRRVGFVFQQWHLFAHRTALGNVTEAPMHVKGVGRQEANERGRALLAKVGLSHREDAYPSELSGGEQQRVAIARALAMEPEVLLMDEPTSALDPERVGALIDLLEQLLADGLTLVAVTHEMRFAYELASRVLVLHGGHIIEEGPPARVLANPHHERTRAFLGLGRVPALRTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D236</accession>
    <name>Q1D236_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555106.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5133"/>
    <dbReference type="EnsemblBacteria" id="ABF91239">
        <property type="protein sequence ID" value="ABF91239"/>
        <property type="gene ID" value="MXAN_5133"/>
    </dbReference>
    <dbReference type="GeneID" id="41362417"/>
    <dbReference type="KEGG" id="mxa:MXAN_5133"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039229_0_0_7"/>
    <dbReference type="OMA" id="SMYPCLA"/>
    <dbReference type="OrthoDB" id="428160at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="383" mass="42506" checksum="1C83F0724615D5F4" modified="2006-07-11" version="1">MSDPARRFVLIGGHEGGTGMSTSVIDNRVEIVFSFDTTGSMYPCLAQVRKKLRGTVSRLMKEIPGIRIGIIAHGDYCDAGSTYVTKMLDLTDDEGAVVRFVDRVEQTGGGDAPECYEFVLRQAQSLSWTVGYTRALVLIGDDVPHGPAQNPHKLDWRKEVAALGKMGIPVYGVQALARRHATAFYKELAEKSGGFHLSLDQFAHVTDLLLAVCYKQSSDVQLQSFEQEVVREGRMSRGLNVMFSTMLQRTAPPLYGEADLRAVPPGRFQVLDVDRTQPIKDFVQENGLRFKTGRGFYEFTKTETIQGRKEVVLMDRKTGDLFSGDRAREMLGLPPGETVRIRPASLEKYVVFVQSTSANRKLMGDSKFLYEVEDWEGASSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D248</accession>
    <name>Q1D248_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555095.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="97" mass="10561" checksum="ACDF6143567B816B" modified="2006-07-11" version="1">MFFPPLQSPESSMKAISKKQQLRKARGQGMTEYIIIVALIAIAAIGVVTLFGDNIRKLFGASADALAGNASVDSEATERQRQLEKKTIKTFGQNNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2C0</accession>
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        <submittedName>
            <fullName evidence="3">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
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        </lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Iartchuk O."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="440"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="57171" checksum="0E7BDB2AB3EE1729" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F1</accession>
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        <submittedName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_5017"/>
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        <property type="reaction ID" value="UER00098"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
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        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 7" id="KW-0418">Kinase</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="324"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="359" mass="37644" checksum="7CD144EEA0790EBA" modified="2006-07-11" version="1">MERALSAPGKLFLSGEYAVLWGGVARLAAVAPRTAAYVRRRADARVHVCLEEGTLAGSTTPLGVRWEREVPAGFAFVARALDEALRAHGRASQGFDLAVAPSAVGPNGQKLGMGGSACATVLAAEGARYVLEERYDALKLALLAHTQGQGGKGSGGDVATSFAGGVLRYRRYDVAPLIEASNTGRLRAALAESPSVDVWRLPSPRVSMAYAFTGESASTRVLIGQVEARLEEAGRRSFVERSDTLGHAIEDGLSGGDFRAFSEAVKAQHALLLELGPLETEGMRRVLALAATYGAAGKLSGAGGGDGCILFAPDAQVRAEMCKGLEARGFHTLPLDAESGVRGEAQAEVRLRTWVRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R2</accession>
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        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_4904</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554885.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4904"/>
    <dbReference type="EnsemblBacteria" id="ABF91302">
        <property type="protein sequence ID" value="ABF91302"/>
        <property type="gene ID" value="MXAN_4904"/>
    </dbReference>
    <dbReference type="GeneID" id="41362193"/>
    <dbReference type="KEGG" id="mxa:MXAN_4904"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014279_0_0_7"/>
    <dbReference type="OMA" id="CENHDEN"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="30667" checksum="399BA590BD8E4994" modified="2006-07-11" version="1">MAREKDNIALSDEHNTRGIELADRGWLDEAIKEFKKAIDLDPSSAHAHDNLATVYAEKKLFREALSEYLTALKLEPESATAHYNLACFLSTHAGEMAVEEYKEAIELDPEYPDAHLNLGLTYADQGRVEEAMRELQTAIELDSQDAFPRHELAALMMDEGDYRSAITQLKEVVRLEPDNFEAQLDLGICFAQKGFYAEAERAYERARALNPEDLLLNYNLSALFALWGRPKDAVQYLQKSLTADRPKVMGWLSTDPMFDALKGDPDFEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D308</accession>
    <name>Q1D308_MYXXD</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D308"/>
    <dbReference type="STRING" id="246197.MXAN_4804"/>
    <dbReference type="EnsemblBacteria" id="ABF90764">
        <property type="protein sequence ID" value="ABF90764"/>
        <property type="gene ID" value="MXAN_4804"/>
    </dbReference>
    <dbReference type="GeneID" id="41362103"/>
    <dbReference type="KEGG" id="mxa:MXAN_4804"/>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003353_4_0_7"/>
    <dbReference type="OMA" id="NFVREFM"/>
    <dbReference type="OrthoDB" id="393769at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009612">
        <property type="entry name" value="IcmF-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010623">
        <property type="entry name" value="IcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017731">
        <property type="entry name" value="TssM1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06761">
        <property type="entry name" value="IcmF-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06744">
        <property type="entry name" value="IcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03348">
        <property type="entry name" value="VI_IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="4">
        <location>
            <begin position="175"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related" evidence="3">
        <location>
            <begin position="479"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF_C" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1231" mass="138126" checksum="3061BBE57A528293" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D322</accession>
    <name>Q1D322_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">MXAN_4789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554776.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4789"/>
    <dbReference type="EnsemblBacteria" id="ABF89494">
        <property type="protein sequence ID" value="ABF89494"/>
        <property type="gene ID" value="MXAN_4789"/>
    </dbReference>
    <dbReference type="GeneID" id="41362088"/>
    <dbReference type="KEGG" id="mxa:MXAN_4789"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_7"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="105"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="35656" checksum="3D1FE1F3969F4CDB" modified="2006-07-11" version="1">MDRQATMEQGLTRVVAAPRLSAAARKRQLREKAVAGFITLMAFTGIAALILIIVFVAKEALTLFTDADARHEASLAKMFLPQEGRYPFRWQPVSDTPKVSMIPLFVGTLKITLVSMLVAVPMGVFSALFVAEFAPRRLRELLKPIIELLAGIPSVVLGFFALMVLSPVVKDLFHLDRPLNGTLAGLALALAIVPVIFTVSEDALTAVPRSYREASLALGATLWETAWKVVLPAAAPGILAACVLGFGRAIGETMIVLMASGNADIVSWNLGDSARSLSATIAAEMGEVVVGSPHYSLLFFIGVELFIFTFVLNMVASTWTKKVLQRLTGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3J6</accession>
    <name>Q1D3J6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554604.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4609"/>
    <dbReference type="EnsemblBacteria" id="ABF89056">
        <property type="protein sequence ID" value="ABF89056"/>
        <property type="gene ID" value="MXAN_4609"/>
    </dbReference>
    <dbReference type="GeneID" id="41361909"/>
    <dbReference type="KEGG" id="mxa:MXAN_4609"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_7"/>
    <dbReference type="OMA" id="TALFMEN"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
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            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
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            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
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        </location>
    </feature>
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            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="477" mass="49885" checksum="BF6690D35577294B" modified="2006-07-11" version="1">MPGHPASSSAEAGGDAPRGSRLASIAVASALFMEFVDSTALSTALPRLSLAFGTDPIHLKLALTSYILALAVLAPASGWVADRFGPRRVFMLAMSVFLLGSVLCGFSQSLTQLVIFRTLQGLGGALMTPVGRIIVVSSAPRERLVAALSWFTMPALVGPLVGPPLAGLILGVADWPWIFFINVPVGILGMLAVARFVPPLHQPDPGPFDTRGFVLVAVAITTLIGAAETVGIGLMPLSLQLGLAAVAFLSLGAYVWHALRVERPVLNLRLLRIDTFRASMIGGTLTRMGLGASPFLLPLLFQVGLGWTPVEAGLVTIGGGVGALACKSVAPYIIRRFGFRQTLIFANLTSAVLTAMPAFFRNSTPIPLIVGVLMVSGFMRSMQFTAINTVAYADIPPDTVSNASTLSVVTMQMALGLGISFGGLMLHLARGAGEAPLTPDRFVLPFIAVGIMSSLAGPLYRRLSPNAGAHIGGRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3J7</accession>
    <name>Q1D3J7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4608"/>
    <dbReference type="EnsemblBacteria" id="ABF86975">
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        <property type="gene ID" value="MXAN_4608"/>
    </dbReference>
    <dbReference type="GeneID" id="41361908"/>
    <dbReference type="KEGG" id="mxa:MXAN_4608"/>
    <dbReference type="HOGENOM" id="CLU_764678_0_0_7"/>
    <dbReference type="OrthoDB" id="1280827at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="40087" checksum="D23C9F78A0D27C31" modified="2006-07-11" version="1">MPQRPTVAEVESILRAPVRQNWEQFTKTLKTLPADVDPDIASHAALSLIHGQPASLWSFGRTCQQLPAPVIRALLGRLEADSRPHAYFLREAVPQEASDEELRAAWKAALQGLLDLETTYAWGSKQRKAKFQVLASTPPLLQAIQTAVVACEQVSLDMLAVLTVDASDASVDALIPHVERAVQSQGWELDRLEDLRKHARSTPVMDDLFARMEALLQGRRARSPALDLARHLGFGELDAIWFRTYLLAGDTHATNSLVHHCNINVDSRTPRWFSVWQRSRMDGHDRNAWSDTRFDNEKLHKDIRGLGACELMQLPDWVARTARRLGTAWNISDSTLFTNLRGKKRARLAEWLRSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K0</accession>
    <name>Q1D3K0_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF89603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4605"/>
    <dbReference type="EnsemblBacteria" id="ABF89603">
        <property type="protein sequence ID" value="ABF89603"/>
        <property type="gene ID" value="MXAN_4605"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4605"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="432" mass="44747" checksum="565B3C520858E123" modified="2006-07-11" version="1">MLRFAIIWGSQTVSKLGSALTSFALGLWVYGLTSSVTDFALISVLTILPGVLVAPIVGVLVDRWDLRNAMRLGDCGAGLVTLVYAILISFDQLAPWHVYVGTALASVSGALQRTSYTALTPALVPAKHLGRANGLVQASDAAVPLIAPPLAGFLMSATSLGTVVLIDFISCLAAITTLSLIRSLPTGSGASSDASTSALQQALEGWNYLKARRGLLGLLAFSVTTNCSLSAMQVLLPPLVLDIANPAVLGGLLSTGGLGLLMGSVVMTAWGGPKNRIHGVLGVGVGLGTVMVLAGLFPTLRMLGYCTFMAGFCIPIMDASSQAIWQGQVPAALRGRVFAMRGMIAWSVQPLAYLAAGVIADHLDGVSFSIPALFGPLEQLDARSRGIALCFIAAGLLALIAAVRGYTARHVREVEEMPPGPPFTGAVSPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T3</accession>
    <name>Q1D3T3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86081">
        <property type="protein sequence ID" value="ABF86081"/>
        <property type="gene ID" value="MXAN_4522"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4522"/>
    <dbReference type="HOGENOM" id="CLU_3357240_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="36" mass="4076" checksum="2250E3C7D3D72AD3" modified="2006-07-11" version="1">MRHGLLRYSLRSPSGGRDMTVAGKRPNFLIITTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3X5</accession>
    <name>Q1D3X5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554475.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4479"/>
    <dbReference type="EnsemblBacteria" id="ABF90230">
        <property type="protein sequence ID" value="ABF90230"/>
        <property type="gene ID" value="MXAN_4479"/>
    </dbReference>
    <dbReference type="GeneID" id="41361789"/>
    <dbReference type="KEGG" id="mxa:MXAN_4479"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_147_1_7"/>
    <dbReference type="OMA" id="IAQVHHL"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="42984" checksum="ABD4F566B75D3126" modified="2006-07-11" version="1">MTDDSTPTHETKFEDPTPENSSDLERARPGLRFTIDTTTYAALRTLERRGNGEVVLLAERHLPHGLAGHVTIKRLRNPASFERCQRLIEEVQLAFRLHHPAIAQVHHLKIHADRPHIIAEYVDGPTLDTVISLATMRERPLCAPFALYIAAEIADALHHSHTLRDSENRPLGIIHRDVAPRNIRVARSGEVKVTDFGAAYSLMVGREETPGLLLKGDVAYASPEYLLRKPMDGRSDIFSLGLVLMEMLTCKHLFDLEDAQAPIAALDVKTEEVPSVPLTQMIALVSRYRSEDVEHAMAGLPDALKAIIHKALQRKPSERYTSAAELRDALRAALAAQAQPFGRKEAAEELARMLSDASVLRDRVELDEAGIFPEGLDADEATLAPNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D459</accession>
    <name>Q1D459_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554392.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4391"/>
    <dbReference type="EnsemblBacteria" id="ABF87267">
        <property type="protein sequence ID" value="ABF87267"/>
        <property type="gene ID" value="MXAN_4391"/>
    </dbReference>
    <dbReference type="GeneID" id="41361701"/>
    <dbReference type="KEGG" id="mxa:MXAN_4391"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826176_0_0_7"/>
    <dbReference type="OMA" id="GKMQNPV"/>
    <dbReference type="OrthoDB" id="1083526at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="35970" checksum="39E18543705472B8" modified="2006-07-11" version="1">MSIDLYGLSRVVGEKGVLPQRAKQLDPSLPCRESELLIDVESLNIDAASFKQIKGEVGGDAKRIGERIQEIVRERGKMQNPVTGSGGMLIGRVKELGARHPARELLKVGDRIATLVSLTLTPLVIEEVKAVHADIDRVDIRGHAILFASGIYAKLPTDMPDTLALAALDVCGAPALVARHVRPGMTVAVLGAGKSGALCLAQARRKLESRGKLLALDVSQGALDLLSGIGLCDVALKVDATQGVDVMEAVSQATDGQLCDLVVNCASVGNTEMATILSVKDGGTAIFFSMATSFTAAALGAEGVGKDVTMVVGNGYVPGHAALTLDLLRTEPQLLQLFGTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4A8</accession>
    <name>Q1D4A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4342"/>
    <dbReference type="EnsemblBacteria" id="ABF88143">
        <property type="protein sequence ID" value="ABF88143"/>
        <property type="gene ID" value="MXAN_4342"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4342"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303811_0_0_7"/>
    <dbReference type="OMA" id="MPERREH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="23211" checksum="52D650B6804BC386" modified="2006-07-11" version="1">MPERREHGGRRHGHRGAEDVHERRRREAGGTDRGRPWRAAGHMAETDVRYGGTQPAGHGPGVENMAPPWDGYSTSPSRSDDHDLGQGGFSGGRYRSEGPVRTPPRGRAPRGYRRSSERILADLCDGLMQSWVDAEDVDIRVRDGVVLLAGVVRSQDERHATEALARDVLGVKEVINDIRIDREDGVVDRPASRSPVQTPGMDASDDDTLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B2</accession>
    <name>Q1D4B2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554339.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4337"/>
    <dbReference type="EnsemblBacteria" id="ABF87517">
        <property type="protein sequence ID" value="ABF87517"/>
        <property type="gene ID" value="MXAN_4337"/>
    </dbReference>
    <dbReference type="GeneID" id="41361649"/>
    <dbReference type="KEGG" id="mxa:MXAN_4337"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006681_0_0_7"/>
    <dbReference type="OMA" id="LGTHEYM"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1296" mass="139696" checksum="E10C670479A41ED3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4G7</accession>
    <name>Q1D4G7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4281"/>
    <dbReference type="EnsemblBacteria" id="ABF92477">
        <property type="protein sequence ID" value="ABF92477"/>
        <property type="gene ID" value="MXAN_4281"/>
    </dbReference>
    <dbReference type="GeneID" id="41361596"/>
    <dbReference type="KEGG" id="mxa:MXAN_4281"/>
    <dbReference type="HOGENOM" id="CLU_585036_0_0_7"/>
    <dbReference type="OrthoDB" id="2030164at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="467" mass="51532" checksum="EA39EB0A7FA246FE" modified="2006-07-11" version="1">MRACACMPTLTPLKSPADALCWVAPPAENPELTSEDPLALDYVSQQVGLWGLPTLTTRSSRAQAYAMVLYGLQLVERAIEHHSYPATDEVRRELFERWERFWALATLEFREGQLPRGDWDSMRGVRGARNAWRSGASSLPLDFQLISRQQELGNLGAYLAPLRRSGLVIEGSLRPGPGALALIDAFWDEPSENKHRGRYEEYALVALDRKSTSIARVHGRLTLAQVGRFSRLSSLVERGRTAQQHRLFEALFVHARDPHSFAMSQLVESAAKAGVAAPRDILDAALAGRLGRLSDELLALLLTARRFGEVMQGLVGAFDRVYSCLDGAGWVAPRERIGREALDAETLGALKGACAALLSSPRVGAIRRLPMHGAAFLRLVEALVDADSLAALDLLLLYHSNVQRERRRGEGWIRNEAGKLVLIVTSYTARPESARFPSFKLDVVRTLLTDLGRLPMSRELDVLEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H1</accession>
    <name>Q1D4H1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S1A (Chymotrypsin) subfamily</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554280.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4277"/>
    <dbReference type="MEROPS" id="S01.B39"/>
    <dbReference type="EnsemblBacteria" id="ABF91987">
        <property type="protein sequence ID" value="ABF91987"/>
        <property type="gene ID" value="MXAN_4277"/>
    </dbReference>
    <dbReference type="GeneID" id="41361592"/>
    <dbReference type="KEGG" id="mxa:MXAN_4277"/>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006842_0_4_7"/>
    <dbReference type="OMA" id="WINTQIR"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="42"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="32876" checksum="6007F28387C5A052" modified="2006-07-11" version="1">MKREVALRFMSGVVVAVGLLGCGGPEVERDPVDTISQMDQEIVGGIEARPHSFPWIVSLQQGTSHFCGGALVRVGAKEESDIVLTAAHCFYDGTSNVTAVAGAHDLYRPTAGQATARVVRAVLHPQYNPDTTMNDIAVLKLDRPIKFDQAVAGACGQSSTMRPNLAAQYASGGTRAPVCLPASGDRVADNTMATVAGWGLTREGGYDTSSLLLQVGVPTLNHRDVANSYRPHGITINEQAMFGAGYKEGGKDACQGDSGGPLIVPGPQGYVLQGIVSFGVGCARAGLPGIYTRVSNYIPWINTQIRTYSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4R4</accession>
    <name>Q1D4R4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554187.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4184"/>
    <dbReference type="EnsemblBacteria" id="ABF89970">
        <property type="protein sequence ID" value="ABF89970"/>
        <property type="gene ID" value="MXAN_4184"/>
    </dbReference>
    <dbReference type="GeneID" id="41361502"/>
    <dbReference type="KEGG" id="mxa:MXAN_4184"/>
    <dbReference type="HOGENOM" id="CLU_1667506_0_0_7"/>
    <dbReference type="OMA" id="CERPAYK"/>
    <dbReference type="OrthoDB" id="2119899at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188366" evidence="1">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17081" checksum="4056A78E61BA0F50" modified="2006-07-11" version="1">MNSKLVFATVALLSTSAFAEEDLKPAQEEAKASFEEKISEALAAANEKCGTKLTVKTDFQNFKPEAWANSSYGSYCEAAINGITSMCERPAYKKAIAKKVTGVSCLFGGVKPPEKKDGTNDATLRNLSLDKGTLTYRMSVDHTNIEDNSKATLEKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D525</accession>
    <name>Q1D525_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554077.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4070"/>
    <dbReference type="EnsemblBacteria" id="ABF90151">
        <property type="protein sequence ID" value="ABF90151"/>
        <property type="gene ID" value="MXAN_4070"/>
    </dbReference>
    <dbReference type="GeneID" id="41361400"/>
    <dbReference type="KEGG" id="mxa:MXAN_4070"/>
    <dbReference type="HOGENOM" id="CLU_1905493_0_0_7"/>
    <dbReference type="OMA" id="EGSMYAG"/>
    <dbReference type="OrthoDB" id="1598690at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="16459" checksum="A35F6763A33407DB" modified="2006-07-11" version="1">MVGPPAYHDAEGRRCLSTVPRPRGPHLPGHMKNLTGVLVFSAVLFLAPGCTRKSGEAPGPTDASAATDEAARTGASKGALRAEDAGSGSTARAAQEACVDSWLQKQGLDAYGNPEGSMYAGGTPLFNERTGEQIDRLDFIFKNKPEVRQACSGDAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5T8</accession>
    <name>Q1D5T8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553815.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3803"/>
    <dbReference type="EnsemblBacteria" id="ABF91793">
        <property type="protein sequence ID" value="ABF91793"/>
        <property type="gene ID" value="MXAN_3803"/>
    </dbReference>
    <dbReference type="GeneID" id="41361134"/>
    <dbReference type="KEGG" id="mxa:MXAN_3803"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_7"/>
    <dbReference type="OMA" id="QHITFKD"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="37697" checksum="537210FEFFECBECD" modified="2006-07-11" version="1">MSVTQADILAAMSKVMDPELHIDLVKAGMVKDIHVSGDTAKLKIELTTPACPMKGKIQADSEAALKAVPGLKSFDIEWGARVRPAGGGMPAGALLPQVKNIILVGAGKGGVGKSTVALNLATALAQHGAKVGLLDADFYGPSVPLMTGLGDKRPVSPDGKSLNPLEAHGLKVMSIGFLVEADQALIWRGPMLHGALMQLVRDVNWGELDYLVLDLPPGTGDVALTLSQSVRAAGAVLVTTPQDVALADVVRAKQMFDKVHIPVLGIVENMSQFVCPNCSHTTAIFNHGGGRKAAQMFGIPFLGEIPLDLKVRESGDSGVPVVVGAKDSPEAKAFQEVARNVAGRVSAQSIKSVPLPVMQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5W6</accession>
    <name>Q1D5W6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ORF">MXAN_3775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553788.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3775"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="ABF90046">
        <property type="protein sequence ID" value="ABF90046"/>
        <property type="gene ID" value="MXAN_3775"/>
    </dbReference>
    <dbReference type="GeneID" id="41361107"/>
    <dbReference type="KEGG" id="mxa:MXAN_3775"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_7"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="200"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="228"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="517" mass="57227" checksum="02CDC3BD125248D4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D605</accession>
    <name>Q1D605_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3733"/>
    <dbReference type="EnsemblBacteria" id="ABF89654">
        <property type="protein sequence ID" value="ABF89654"/>
        <property type="gene ID" value="MXAN_3733"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3733"/>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_1_7"/>
    <dbReference type="OMA" id="KLWGALL"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="36166" checksum="B2BFB107CF3A86BC" modified="2006-07-11" version="1">MALATPRAGAAAYAPCDNMIDYDPHRWWSYFHYLRGSMVREIVARVLICVLWAVGVTAVHHHTKPLDIPATVHTLAGISLSLLLVFRTNASYDRFWEGRKLWGGIVNETRNLARASSVFMRRDAGLYGTLVRWISAFPYAAAASLRGERDLGPVASELPRDEADAVLGSQHVPLAVSQKMSAVLDEGRLRGYYPEHVQMQLDQNVQLLIDYIGGCERIHKTPMPFAYMMHLRRALMVYCYTLPFALVDSFGWITVPATFVVAYVFFGIEEIGVEIEDPFGHDDNDLPLERICETIHGNLKALMPGSAEAIHAPVSVVAIPGGGQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D611</accession>
    <name>Q1D611_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553743.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3727"/>
    <dbReference type="EnsemblBacteria" id="ABF87358">
        <property type="protein sequence ID" value="ABF87358"/>
        <property type="gene ID" value="MXAN_3727"/>
    </dbReference>
    <dbReference type="GeneID" id="41361060"/>
    <dbReference type="KEGG" id="mxa:MXAN_3727"/>
    <dbReference type="HOGENOM" id="CLU_2330800_0_0_7"/>
    <dbReference type="OMA" id="DHAPRWR"/>
    <dbReference type="OrthoDB" id="2098474at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="98" mass="11007" checksum="165A80560CB8B6D2" modified="2006-07-11" version="1">MSTDFAADHAPRWREGVSGQRFGSDFIVLDAEGNTLRGLNGTAIEIWELCDGTRTARALVEQVAQRHGWDVEQVLTDTLKFFSELTRLGLIDELEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D613</accession>
    <name>Q1D613_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisS</name>
        <name evidence="11" type="ORF">MXAN_3725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553741.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3725"/>
    <dbReference type="EnsemblBacteria" id="ABF85996">
        <property type="protein sequence ID" value="ABF85996"/>
        <property type="gene ID" value="MXAN_3725"/>
    </dbReference>
    <dbReference type="GeneID" id="41361058"/>
    <dbReference type="KEGG" id="mxa:MXAN_3725"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_7"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF85996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="47022" checksum="FAD55DBCF7A25754" modified="2006-07-11" version="1">MSQKVAGVKGMNDLLPGEIEIWQHVEAQARELFGRFGYGEIRTPMVEDTALFVRSVGEETDIVGKEMYTFNDKADRSLSLRPEGTAPAARAYIEHSIANQEPLTRWFYAGPMFRYERMKTGRYRQFYQIGAEAYGAKEGAQDVEMMDMVVQFLERLGLKDITLNINSLGDEVCRPTYHAKLVEYLQAHREALCGDCQKRMEKNPLRVLDCKNEKCQAIAAAGPNVLESLCEPCRAHFDDVQRKLTALGVRHVVNPRMVRGLDYYTRTVFEFIASHPALGTASTVGAGGRYDKLVKSLGGPDAPAVGFACGLDRLVLLLKESGQQFTVRPDVFVAVADAGSHDAALVLASRLRREGLRVEFDTRGGSLKSQMKRADKSSAEFTLVLGEAERTSGQAKLKPMAGGEPIPVALDEVARVVRERKVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D675</accession>
    <name>Q1D675_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553679.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3661"/>
    <dbReference type="EnsemblBacteria" id="ABF88771">
        <property type="protein sequence ID" value="ABF88771"/>
        <property type="gene ID" value="MXAN_3661"/>
    </dbReference>
    <dbReference type="GeneID" id="41360997"/>
    <dbReference type="KEGG" id="mxa:MXAN_3661"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939497_0_0_7"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021948">
        <property type="entry name" value="DUF3565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12088">
        <property type="entry name" value="DUF3565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="130"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="32935" checksum="487EEC7E907D7DD0" modified="2006-07-11" version="1">MKQKITGFHLDREDHWVADLKCGHRQHMRHDPPWMVRPWVLSEDGRRSRLGVELDCKRCDEAGHAVAEAVREALRTVALRAYDDGGLSGLCAEGRWELALDALGAADLRPVIRRALAPERGEGALVSARMILRPLLPDDARAIQRLAGDREVAANAAGIPHPFEDGMAEAWIASLDARSHVFALGHSESGEFMGLAGLVEADEERPRTAELSYWLGRAYWGQGFGTEAAQTLVRYGFETLGLESLHASCFSRNPGSRRVLEKAGFRHAGHQARALRHLGQDEDLERFIQERSRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6F9</accession>
    <name>Q1D6F9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553600.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3574"/>
    <dbReference type="EnsemblBacteria" id="ABF92622">
        <property type="protein sequence ID" value="ABF92622"/>
        <property type="gene ID" value="MXAN_3574"/>
    </dbReference>
    <dbReference type="GeneID" id="41360920"/>
    <dbReference type="KEGG" id="mxa:MXAN_3574"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019123_3_1_7"/>
    <dbReference type="OMA" id="VNSFRQD"/>
    <dbReference type="OrthoDB" id="692608at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="DUF3520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022156">
        <property type="entry name" value="Uncharacterised_YfbK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="DUF3520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12450">
        <property type="entry name" value="vWF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="245"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="592" mass="63113" checksum="49B5DC26F8F379A2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6G6</accession>
    <name>Q1D6G6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553593.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3567"/>
    <dbReference type="EnsemblBacteria" id="ABF91593">
        <property type="protein sequence ID" value="ABF91593"/>
        <property type="gene ID" value="MXAN_3567"/>
    </dbReference>
    <dbReference type="GeneID" id="41360912"/>
    <dbReference type="KEGG" id="mxa:MXAN_3567"/>
    <dbReference type="eggNOG" id="COG5470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131535_1_0_7"/>
    <dbReference type="OMA" id="ELMLIGP"/>
    <dbReference type="OrthoDB" id="1534521at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13666" checksum="8EA8039370DA2161" modified="2006-07-11" version="1">MAVDPQHTDVERFMREDPGGPVVILNLVRFKEGGRASYEAYASAVMPFIQKVGAQPLYAGDGSTALVADPGQTWDAVLLVRYPSRAAFLQMVADPEYQHIAHLRTEALQEAVLQATTPWATSPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S4</accession>
    <name>Q1D6S4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UvrABC system, A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">MXAN_3452</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF91991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3452"/>
    <dbReference type="EnsemblBacteria" id="ABF91991">
        <property type="protein sequence ID" value="ABF91991"/>
        <property type="gene ID" value="MXAN_3452"/>
    </dbReference>
    <dbReference type="GeneID" id="41360800"/>
    <dbReference type="KEGG" id="mxa:MXAN_3452"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_2_1_7"/>
    <dbReference type="OMA" id="TMRRADW"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
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    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="509"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="536"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF91991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="850" mass="92213" checksum="7ED2C82CAD9914EC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D737</accession>
    <name>Q1D737_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="5" type="ORF">MXAN_3337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-61 and Arg-64) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553372.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3337"/>
    <dbReference type="EnsemblBacteria" id="ABF88360">
        <property type="protein sequence ID" value="ABF88360"/>
        <property type="gene ID" value="MXAN_3337"/>
    </dbReference>
    <dbReference type="GeneID" id="41360690"/>
    <dbReference type="KEGG" id="mxa:MXAN_3337"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_7"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26678" checksum="574A3F96F2F2E627" modified="2006-07-11" version="1">MDSLILDSNTWLLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRKAAAAVHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPPFEDATVYPAGAVPECDACGKLLRPHIVWFGEYLDPADIQRIEDFSLRAATSGGRFVFLAAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPTLAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7C4</accession>
    <name>Q1D7C4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Senescence marker protein-30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553295.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3250"/>
    <dbReference type="EnsemblBacteria" id="ABF86743">
        <property type="protein sequence ID" value="ABF86743"/>
        <property type="gene ID" value="MXAN_3250"/>
    </dbReference>
    <dbReference type="GeneID" id="41360602"/>
    <dbReference type="KEGG" id="mxa:MXAN_3250"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_3_1_7"/>
    <dbReference type="OMA" id="AGTMRYD"/>
    <dbReference type="OrthoDB" id="852341at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="32576" checksum="2017BB2BAC4B2067" modified="2006-07-11" version="1">MRTTDVARHDEARCIWPARAVLGEGPFWMATEGALYWLDIPGRKVHRLELQSGAQASWDTPLRIASLAPRRSGGFIAGTERGLAFYEPRSARLERLLDPEPEHPHNRCNDGKVDPQGRFWVGTMDDHEEAPTGGLYRFDAQGHLARIDEGYTVTNGPAFSPDGRTLYVNDSPRRVTYAFDLSPDGAASRRREFLRFDEPHGFPDGMTADAEGGLWIAFYGGGCVRRFSPDGAWLAEYRLPVAKTTSVAFAGDALDRLFVTTGRDGLSAEELEAQPLAGGLFELTPGVRGVAPVPFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L3</accession>
    <name>Q1D7L3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553206.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3157"/>
    <dbReference type="EnsemblBacteria" id="ABF87650">
        <property type="protein sequence ID" value="ABF87650"/>
        <property type="gene ID" value="MXAN_3157"/>
    </dbReference>
    <dbReference type="GeneID" id="41360516"/>
    <dbReference type="KEGG" id="mxa:MXAN_3157"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2570246_0_0_7"/>
    <dbReference type="OrthoDB" id="1857145at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="81" mass="9200" checksum="2832403F9C4FF8F2" modified="2006-07-11" version="1">MEFHKGRLFDHVHLRVQDLDASKRFYRAVLDVLGVPFFSESPHHPGYYGAFVLDPDGNNIEAVFHGPVTRSAESVVMKPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7T7</accession>
    <name>Q1D7T7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553133.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3083"/>
    <dbReference type="EnsemblBacteria" id="ABF92795">
        <property type="protein sequence ID" value="ABF92795"/>
        <property type="gene ID" value="MXAN_3083"/>
    </dbReference>
    <dbReference type="GeneID" id="41360445"/>
    <dbReference type="KEGG" id="mxa:MXAN_3083"/>
    <dbReference type="HOGENOM" id="CLU_1693588_0_0_7"/>
    <dbReference type="OMA" id="IPGKQAG"/>
    <dbReference type="OrthoDB" id="1439199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="16952" checksum="15A8E66DF7883B32" modified="2006-07-11" version="1">MFNLDERYRGLPATREQILALHTSLNAPHVAIPGKQAGPAQAFVVGLRGGQGTAAVFVYLYLAEAADCAVYLSGRRNVSADEYRDDEGDALAFVESLGFMMDDANWRAMAPEQQDEQLKTLPVFFKDPTLVPAVVARAEEKKNVTTTLGRFLAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D810</accession>
    <name>Q1D810_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553060.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3004"/>
    <dbReference type="EnsemblBacteria" id="ABF88211">
        <property type="protein sequence ID" value="ABF88211"/>
        <property type="gene ID" value="MXAN_3004"/>
    </dbReference>
    <dbReference type="GeneID" id="41360365"/>
    <dbReference type="KEGG" id="mxa:MXAN_3004"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1553639_0_0_7"/>
    <dbReference type="OMA" id="MNLIIFM"/>
    <dbReference type="OrthoDB" id="1299910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="18796" checksum="58CAF155CE51C2A4" modified="2006-07-11" version="1">MAFHYSRRKLKVREEEEAGELNIVPYLDILMNLIIFMLLSITGLATFGIINVNAPAYGAPTTGMAQENPDDAPKLTLSVLISKKGHFVSSENAILGEAGTPTIPVKADGAHDFSALNAKMVEIKSAFPKETKVIVGADPDVPYETLTQTLDAIRETQGRERRLLFPDVTLGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D847</accession>
    <name>Q1D847_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="36489" checksum="6A2252B3B99B93EB" modified="2006-07-11" version="1">MATRIAINGFGRIGRCILRAVLSRKEDLEIVAINDLDKPAALAHLFKYDSVHRTWPGEVKATEKGIVVDGKEITVTAEKDPTALPWKSLNVDVVLECTGRFTARDAAEKHLKAGAKKVIISAPAKGPDITIAYGINHNEYDPAKHHVISNASCTTNCLAPIAKVLVDNFGIEKGLMTTVHSYTNDQRILDLTHEDMRRARAAALSMIPTSTGAAKAIGEVIPQLKGKMHGLAVRVPTPNVSLVDLTVNTEKKVTAEAVIEAFRKAAEGPLKGVLEFSDAQTVSVDYNGNPHSAIFDSTNCFVMGDNLLKVMAWYDNEWGFSNRMVDTAKFLVSKGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8L9</accession>
    <name>HGD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homogentisate 1,2-dioxygenase</fullName>
            <shortName evidence="1">HGDO</shortName>
            <ecNumber evidence="1">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hmgA</name>
        <name type="ordered locus">MXAN_2787</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>homogentisate + O2 = 4-maleylacetoacetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="EC" id="1.13.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Hexamer; dimer of trimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8L9"/>
    <dbReference type="SMR" id="Q1D8L9"/>
    <dbReference type="STRING" id="246197.MXAN_2787"/>
    <dbReference type="EnsemblBacteria" id="ABF89328">
        <property type="protein sequence ID" value="ABF89328"/>
        <property type="gene ID" value="MXAN_2787"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2787"/>
    <dbReference type="eggNOG" id="COG3508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027174_0_0_7"/>
    <dbReference type="OMA" id="FMFETRW"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00334">
        <property type="entry name" value="Homogentis_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022950">
        <property type="entry name" value="Homogentis_dOase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="chain" id="PRO_1000119844" description="Homogentisate 1,2-dioxygenase">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00334"/>
        </source>
    </evidence>
    <sequence length="437" mass="47825" checksum="81D91E3D65FD8B54" modified="2006-07-11" version="1">MSPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRRENRRSWLYRLRPSANHPAFQPLAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGLVTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLIVPQAGRLRLVTELGVLDVAPGEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFEDVDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSIFTVLTSPSEVPGTANCDFVIFPPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGFAPGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAFMFESRWVIRPTRFAMETPALQQDYDACWAGFQKAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8W6</accession>
    <name>Q1D8W6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552758.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2690"/>
    <dbReference type="EnsemblBacteria" id="ABF93137">
        <property type="protein sequence ID" value="ABF93137"/>
        <property type="gene ID" value="MXAN_2690"/>
    </dbReference>
    <dbReference type="GeneID" id="41360068"/>
    <dbReference type="KEGG" id="mxa:MXAN_2690"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034186_0_0_7"/>
    <dbReference type="OMA" id="HEAVGHR"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="320"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="591" mass="65292" checksum="809A6768D10740BC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9C5</accession>
    <name>Q1D9C5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2529"/>
    <dbReference type="EnsemblBacteria" id="ABF90360">
        <property type="protein sequence ID" value="ABF90360"/>
        <property type="gene ID" value="MXAN_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2529"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_2_1_7"/>
    <dbReference type="OMA" id="TMWMKNT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14947" checksum="F923F8A751D330F9" modified="2006-07-11" version="1">MQPLPRGHVRLEDAFGGARRVEVEIAATAGTRARGMMWRKELAEGKGMLFLFPHEEVQGFWMRNTLIPLDMIFITSDLRVAGIVSRAVPRSLESRSVGVPSQYVLEVPGGWTEKLGIRKGSTVRFEGVAGLDIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E2</accession>
    <name>Q1D9E2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General secretion pathway protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gspF</name>
        <name evidence="9" type="ORF">MXAN_2512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552583.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2512"/>
    <dbReference type="EnsemblBacteria" id="ABF90238">
        <property type="protein sequence ID" value="ABF90238"/>
        <property type="gene ID" value="MXAN_2512"/>
    </dbReference>
    <dbReference type="GeneID" id="41359889"/>
    <dbReference type="KEGG" id="mxa:MXAN_2512"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_7"/>
    <dbReference type="OMA" id="VAEQCEK"/>
    <dbReference type="OrthoDB" id="1596769at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011850">
        <property type="entry name" value="T2SS_GspF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02120">
        <property type="entry name" value="GspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="84"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="287"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="418" mass="45535" checksum="D54C9D28749DAE79" modified="2006-07-11" version="1">MPVFEYRGLNSAGKQIKGLLEADSPKTLRSKLRADGIFLTDVLAQAEGSRAAVAKGTNAALVARDIDLRKLGRGRVNTDDVAIFTRQLSTLLGAGVTLVESLSALVDQVEKERFKRALSDIKQRVNEGSSLAEAMGQHPKIFPSIYVNMVRAGEASGALDAVLTRLADFTENQARLQQKILSTMLYPAIMMVVGGGILVALMVFVVPKVTKIFETMKATLPLSTRFLIASSNFFQSWWFILLPAMALGVVLFMRWTKSPSGKPKWDRITLKAPVVGNLVRLLSISRFARTLSTLLKSGVPLLAAMDIVKAIMTNTVLAEVVEKARDSIREGESIANPLKRSGEFPPLVYHMVAIGERSGQLEEMLTSVADNYETQVNVRISALTSLLEPLLIVVMGAVIAFVALSILMPILQVNSAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9J5</accession>
    <name>Q1D9J5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1521 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552531.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2458"/>
    <dbReference type="EnsemblBacteria" id="ABF92166">
        <property type="protein sequence ID" value="ABF92166"/>
        <property type="gene ID" value="MXAN_2458"/>
    </dbReference>
    <dbReference type="GeneID" id="41359841"/>
    <dbReference type="KEGG" id="mxa:MXAN_2458"/>
    <dbReference type="eggNOG" id="ENOG5033MSF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059916_0_0_7"/>
    <dbReference type="OMA" id="SADVFHM"/>
    <dbReference type="OrthoDB" id="571746at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011086">
        <property type="entry name" value="DUF1521"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07481">
        <property type="entry name" value="DUF1521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1521" evidence="1">
        <location>
            <begin position="99"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="41771" checksum="379DD559F14DBB8F" modified="2006-07-11" version="1">MSNGIGGVGGNRQLTTTQGVGNVNTSTIARNAQLIESTLNLVEKAVDLAGKAVNVAGKAVDQMSQAAAPTKQAGATGTNAAFPAERPNPLDAVREANSLKVEEGTGKITTPGGYTIEQLGQFEWRVTGPDGKNTRVWGDPHVDESDGGKFDFKRDTSFVLGDGTRINCSCKPWGNGMTVTGQLDVVYGDSHVRVTDIDKGKGKVGQVTNKGMDEVVRFHSNQSADVFHMGQNAADWTFHGKEIVGHENGGDVHKVGEAVITERRTMAFNYSAAADSPAAGEVAQNWDMNTNLPQVKPLPWDMSSAKPELNKLNETFDSISKVFDQLKNTNANGFNPFRKADDLFGAYDKNQHKSGLTQSFKALGDMFGTLEKLSKLNDMVRFRGPQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9J8</accession>
    <name>Q1D9J8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91484">
        <property type="protein sequence ID" value="ABF91484"/>
        <property type="gene ID" value="MXAN_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2456"/>
    <dbReference type="HOGENOM" id="CLU_1330756_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="22966" checksum="E99F1DE90FCC44BA" modified="2006-07-11" version="1">MLLRARAPRRAAHSPSLAPRKAKPPLRSETRAAASRTGVRRGRSRSGYSPHMSLRSSLRRLISFPKKLSSRIFWNIAFVSCFFVVDSACDLTSSAEAFGLLLRKVSISPWTFSFTVLIRPSPRYWRLPLISGSFIRSTAEFSTPSHACFWASGVVVVDLRVVADALFAILVVTGKSPRKKRTSRGSYRRRQAPSCVPRAQAPTRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M0</accession>
    <name>Q1D9M0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552508.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2433"/>
    <dbReference type="EnsemblBacteria" id="ABF92644">
        <property type="protein sequence ID" value="ABF92644"/>
        <property type="gene ID" value="MXAN_2433"/>
    </dbReference>
    <dbReference type="GeneID" id="41359817"/>
    <dbReference type="KEGG" id="mxa:MXAN_2433"/>
    <dbReference type="HOGENOM" id="CLU_2381292_0_0_7"/>
    <dbReference type="OMA" id="EMLVETR"/>
    <dbReference type="OrthoDB" id="1881479at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="100" mass="10692" checksum="FCC021F6C5BAAC42" modified="2006-07-11" version="1">MARQETVSAMPPTAKPSQTAQDLPAPSFPAIESLLEAASVEEVRGFFDGVKTGLTELKGPKVEQGKKAQAAIGRAEELLEMLVETRERLIAESKGGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9S3</accession>
    <name>Q1D9S3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2380"/>
    <dbReference type="EnsemblBacteria" id="ABF87375">
        <property type="protein sequence ID" value="ABF87375"/>
        <property type="gene ID" value="MXAN_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2380"/>
    <dbReference type="HOGENOM" id="CLU_1146242_0_0_7"/>
    <dbReference type="OMA" id="VWGVENR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="289" mass="30375" checksum="5BBF828797E2F886" modified="2006-07-11" version="1">MRRPRGVSQSANSLGKAFIAAEHIAPRNLYSCLAIITDKLIFPGAPQAMSRIDSRPRVISNPTTAPARAQPAAQQAANVARATAVGHTQVNSFEGAARARPAAAAQPIPGAWRGGPDTEVGKAVQSIVSRLQANPDANNITIKGDTAASLFSRAILDSKHVTNEQLIAMANVSLDQLASDEKTKAKVYKKVPNVRDLPVHKFTVAMMSAATGIDPQKLSEAVPDLGLTGAPNTPLLYAAKGEGMQRSTALHDFTDYLRGAGIKGLNKAVWGVENRVLSAIVSAVGGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z0</accession>
    <name>Q1D9Z0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytochrome_C554 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552388.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2313"/>
    <dbReference type="EnsemblBacteria" id="ABF86077">
        <property type="protein sequence ID" value="ABF86077"/>
        <property type="gene ID" value="MXAN_2313"/>
    </dbReference>
    <dbReference type="GeneID" id="41359700"/>
    <dbReference type="KEGG" id="mxa:MXAN_2313"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838942_0_0_7"/>
    <dbReference type="OMA" id="REWPHEP"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="1">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="38531" checksum="59C935BE77B84CD0" modified="2006-07-11" version="1">MRRCIAPLPITPTVRATVSVLVLFTCSLLATAPTSRFPKGTARMDVGPAPHGLPDWNVQRCAECHAVQVDSWRHSGHATARTDDVFQVALTEDRPGWCVQCHAPLARNLERGPLPKDSPPEEHGVTCAGCHAPTGNEGQAPGMPCAGCHQFGFPVLTSAGQRVRLSPTQLQQDTVGEWRRWQTQSGDTRHCTSCHMPQGDHGFGGTRRTESLKAALRVVQASAFLRISTREVGHAFPSGDVMRWVSVEVSEGPLFETSRTVATFGRSLEVREWPHEPLPHLGAVKDTRLLPGETRQVLLPKGARYARVVYHLVSREQEDSGLYPPGLSQLVLWAEPLQPFPSSHTPKERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA22</accession>
    <name>Q1DA22_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552356.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2280"/>
    <dbReference type="EnsemblBacteria" id="ABF92151">
        <property type="protein sequence ID" value="ABF92151"/>
        <property type="gene ID" value="MXAN_2280"/>
    </dbReference>
    <dbReference type="GeneID" id="41359667"/>
    <dbReference type="KEGG" id="mxa:MXAN_2280"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_1_7"/>
    <dbReference type="OMA" id="RMFVAWG"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="35973" checksum="780624990CCCCFD7" modified="2006-07-11" version="1">MLLAAVILIVAVALIFDFINGFHDAANSIATVVSTRVLSPNLAVAWAAFFNFVAAFGGNVHVANTMGKGIINFEMLRAQGPSAVLAVIFSALMGAIVWNLLTWWWGLPSSSSHALAGGMIGATLPVLGFAGLVGSGIAKIAAFIVLSPLIGMTLGIGLMVLSTWAVHRQTPLKVDSWFRRLQLVSSAIFSYSHGTNDAQKVMGIIAVVLFGTIWQDRPFHIDWWMIISCHAAIALGTFFGGWRIVRTMGHSLTKLAPIGGFAAETGGGVTIIALAQLGIPVSTTHTITGAIVGVGATRGWRAVKWGVAGRIIWAWVVTIPAAALTAVVFYGLTQVVMRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA27</accession>
    <name>Q1DA27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
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                <person name="Kaplan H.B."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="280"/>
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        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="719" mass="78413" checksum="B44134E1AE1740ED" modified="2006-07-11" version="1"> </sequence>
</entry>
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    <accession>Q1DAL1</accession>
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        </submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="14085" checksum="671E6B5F6012BDC7" modified="2006-07-11" version="1">MSWALDSAPFSVPLRRVHLGVAPRLRTVSQESFAMAETQTTQKRTSWPRFAKSNGKKACTVEGCKRPYRAKNYCYFHYKQWRQGDLPHSRYRTCSKPDCRVKTFKGGLCEKHHGEAFKKDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB7</accession>
    <name>Q1DBB7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">MXAN_1810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="246197.MXAN_1810"/>
    <dbReference type="EnsemblBacteria" id="ABF86927">
        <property type="protein sequence ID" value="ABF86927"/>
        <property type="gene ID" value="MXAN_1810"/>
    </dbReference>
    <dbReference type="GeneID" id="41359226"/>
    <dbReference type="KEGG" id="mxa:MXAN_1810"/>
    <dbReference type="eggNOG" id="COG1714">
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    </dbReference>
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    <dbReference type="OMA" id="PAEVWRI"/>
    <dbReference type="OrthoDB" id="1974702at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="21714" checksum="06F7C55875285A1A" modified="2006-07-11" version="1">MSDFREALESISKSPCSKHPGFSAALACIRCGTFICAFCASSSGGLCFRCLHAAPELATRRARLAASLVDGVALLLPSLLLGVLRCLALPDEAAMTAPAVYVPALLVLLVQASLIRGAGASLGKRLLGIRVVRRDGRPAEVWRIALLRNALPIALCGYCGWFSLVDALFIVGEDRRCLHDWLAGTRVVKAPRSPRSFAARLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR1</accession>
    <name>Q1DBR1_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1660</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1660"/>
    <dbReference type="EnsemblBacteria" id="ABF90564">
        <property type="protein sequence ID" value="ABF90564"/>
        <property type="gene ID" value="MXAN_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1660"/>
    <dbReference type="HOGENOM" id="CLU_1141601_0_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26209" checksum="20CC4CBB2CCC3A54" modified="2006-07-11" version="1">MPAVKGFLPRASELAEGGGMTSKSCDGYQLALEMSRHGALDVREKEEAEQHAATCPECQRALALSAEMDQALGGVSIPAPRYAEVSRALAKDRFWLKYGPWAALGSFVGQGVFLGPLFAPEAPLRLWAIVSAVGVLFAGGLVLTLRGLQRRAIEAASVGVDAWMAQRRARIDTELKDLTTLLWLFPAMTVAMAGTAFLMRDKGLPGVVTLLFAAGVNLGMTVYLARTRRPRLLRERAELEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC58</accession>
    <name>Q1DC58_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551624.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1513"/>
    <dbReference type="EnsemblBacteria" id="ABF91615">
        <property type="protein sequence ID" value="ABF91615"/>
        <property type="gene ID" value="MXAN_1513"/>
    </dbReference>
    <dbReference type="GeneID" id="41358959"/>
    <dbReference type="KEGG" id="mxa:MXAN_1513"/>
    <dbReference type="eggNOG" id="ENOG5031IXM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1487529_0_0_7"/>
    <dbReference type="OMA" id="HTLECEP"/>
    <dbReference type="OrthoDB" id="1786098at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="19649" checksum="97E3A2ECD56C6DEF" modified="2006-07-11" version="1">MLKPHLTRDSAEQYVLGALAPEKAASLEAHTLECEPCARLLQEEALLSEQLHEVANTYAPAVHVLRPARWETRRLTAGLAGAALAAAAAWAFVVLPGGRQPPASPRTLALHVEPPSVELELEVAEPQSIVVACPDLATQASCTQAAEERGLLVQYPWGTGEVPRYEARTGLPEGALSARRPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC76</accession>
    <name>Q1DC76_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase, FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551606.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1495"/>
    <dbReference type="EnsemblBacteria" id="ABF90028">
        <property type="protein sequence ID" value="ABF90028"/>
        <property type="gene ID" value="MXAN_1495"/>
    </dbReference>
    <dbReference type="GeneID" id="41358941"/>
    <dbReference type="KEGG" id="mxa:MXAN_1495"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_1_7"/>
    <dbReference type="OMA" id="MYIGYVG"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="53134" checksum="F35AC86833AD6EE6" modified="2006-07-11" version="1">MHADVVTQHAVVIAGGGPTGLMLAAELALAQVDVAIVERRVSQEVAGSRARGLHARSLEVLDQRGVVERFTSQGQAVQNVAFGQAHLDLSDFPTRHNHGLALLQERFERILAEWVGELAVPIYRGCEVTGFTQDDTGVDVELSDGRALRAKHLVGCDGGRSLVRKAAGIEFPGWDASISYLIAEVEMTGAPAFGIRRDEKGTYAMGKLEDGRVGVVLREERVGTGDAPTLEGLREGLVALYGTDYGLRSATHLSRFTDMTRQAASYRDRRVLLAGDAAHVHSPMGGQGLNLGVQDAVNLGWKLAQVVRGVSPESLLDTYQAERHPVAARALRKTMAQTALSRGDARMDAVRETLAELLGMDGPRKQYAAMMSGLDVHYDLGNGHPLLGRRMPDLDLVTADGPRRVFHLLHDARPVLLNLGEPGTLDITPWGDRVRRVAARYTGEWELPALGAVTAPVAVLIRPDGHAAWVGEGTDQGLREALARWFGPPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC89</accession>
    <name>Q1DC89_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551593.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1477"/>
    <dbReference type="EnsemblBacteria" id="ABF92533">
        <property type="protein sequence ID" value="ABF92533"/>
        <property type="gene ID" value="MXAN_1477"/>
    </dbReference>
    <dbReference type="GeneID" id="41358923"/>
    <dbReference type="KEGG" id="mxa:MXAN_1477"/>
    <dbReference type="HOGENOM" id="CLU_754046_0_0_7"/>
    <dbReference type="OMA" id="NCQSGTM"/>
    <dbReference type="OrthoDB" id="544848at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188609" evidence="1">
        <location>
            <begin position="25"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="39504" checksum="551B7D637E69E2FE" modified="2006-07-11" version="1">MKRPMRAAALSFCLLFCAPGVASAQADRPSKPVPSLAKPPRIQGGLKAFASPMVLKPVAVEGATASFTAKVGARKDTLYVGVEATDDQLQAGDLLTLSLYFPGTGPTAAGYTWRFAFDGKRASGAESGTPQFAQDLVTAAVQRQGNTLLLMASVPVRAFPRFPAVDPLVMDLCLTYEDRDSADGKATSISNCQSGTMVGDALRLPDEPRKGLKLKLPENVTSLEPKEDGLLGWDYMSYPAWAQADDELAPASLRRLVAPDAVVPSSVDLNVPDTLTLEDGGRVVTVVTGKNPYAVAGQCDADDELRLGLYLVTGKTAQRVLEWPAATCALGRTSSVELEEEGVLSIRYSNGTSMNFAWSGTHFSRTELGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC91</accession>
    <name>Q1DC91_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1475"/>
    <dbReference type="EnsemblBacteria" id="ABF92875">
        <property type="protein sequence ID" value="ABF92875"/>
        <property type="gene ID" value="MXAN_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1475"/>
    <dbReference type="HOGENOM" id="CLU_844192_0_0_7"/>
    <dbReference type="OMA" id="AGWEDCC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="42130" checksum="B08699F865282C0A" modified="2006-07-11" version="1">MSASPRRWVRAWPCRREALPRVSPRQGSGSWSRKTPVSVAWTGAGVLRSPLAHMRPSPTEFDRQYTEQRRSIELARRYLEKEGVSRMYDALSKEVERGRLSVQDASGAIRFGLLAVIERVAERVGHTHYVDMLKDEEMLNALRSTLDDICRRKGVDTFEFRQQWAHTNLQAVLRDWHLVVHEERGRQRYEVAADLARRLVKETPGTVLAQTLKLPADAFVLLVSPEAGLVGLGPDGTPAPITEIYAVESPAPEGKAWFLWLNMRDAGNRAARALINVYLQDGKTLDDAIAFTREQGGPQQDAGWEDCCRLLAGVARHMAESGPVREVWYDATARELHEKLAATPKSAKADREKLRERLRAVSPGRTLVLEEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS7</accession>
    <name>Q1DCS7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1289"/>
    <dbReference type="EnsemblBacteria" id="ABF88170">
        <property type="protein sequence ID" value="ABF88170"/>
        <property type="gene ID" value="MXAN_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1289"/>
    <dbReference type="eggNOG" id="COG5285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722947_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="44239" checksum="73462D1C8DC76869" modified="2006-07-11" version="1">MATNAPRPLDSRAALAGRRSMNDPVNTEATAHQTEAFRREGYVVIEQALSDDFLDVLRADFEQALHAKVARFDLKPAPRDARCEANDGVLNDFQPDGGNHDFNRWNMHLPSRRPYFEAMLVDNPRITGVIDQLLGPDWVYYIIASDTPFPNAGFQTAHQDYTRFSIAINIPLVDVTPDNGPMEVWPGTHQPPSEGRLAPFTTGAHRIDEPTLKSLVRRIPSRKLVMRRGAVLIRDHRMVHRGTPNLADAPRYMLSLYCIAAEQVPYRLLSDAGATLALSLRRMGRGSGAAVRHRRLFDLGAVLGRVVEECSLSDRDYRRTFSAELWASLGPRARHHLRFARVQGEDRVRGQGDLKGSGAFLKRYAQSISEALQRPDGRPRLPDHYAEGRPGTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT6</accession>
    <name>Q1DCT6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551397.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1280"/>
    <dbReference type="EnsemblBacteria" id="ABF90348">
        <property type="protein sequence ID" value="ABF90348"/>
        <property type="gene ID" value="MXAN_1280"/>
    </dbReference>
    <dbReference type="GeneID" id="41358726"/>
    <dbReference type="KEGG" id="mxa:MXAN_1280"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789463_0_0_7"/>
    <dbReference type="OMA" id="EWCREDG"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="353" mass="37775" checksum="BB9BB4414D27EB96" modified="2006-07-11" version="1">MLETTEGSIVRATLRALVEPRRLLPILVISVALITAQVRFSHAPLWAAFGLGLLMCLLFIAVAPVSYRVLFPEGLDLSHGGIRLLLYATVGSGVVLTSGFVLPKLLGMGPTFLTQPTNLAVCGALFLVGGWGLGRDIGFEESLTRERARAARFALEAEQAQLLALRSHLDPHFLFNTLNAIAEWCREDGAVAETAVLRLSTMLRSVLAGVRSATWPLAQELELIRTLFDLHLLRDPDLFQLTLNIPAGMEEIPVPPLVLLPLAENAVKHGPAAGHRGPLSLDVTARGHEVEVAIENPGPSRGPREGSAGLPTVERRLALAYGGAARLVLDGGEARTRVTVTLPRAGPQPGVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD01</accession>
    <name>Q1DD01_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1213"/>
    <dbReference type="EnsemblBacteria" id="ABF88736">
        <property type="protein sequence ID" value="ABF88736"/>
        <property type="gene ID" value="MXAN_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1213"/>
    <dbReference type="eggNOG" id="COG4695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642241_0_0_7"/>
    <dbReference type="OMA" id="RGMSWLT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006944">
        <property type="entry name" value="Phage/GTA_portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04860">
        <property type="entry name" value="Phage_portal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="452" mass="49899" checksum="227C071433DC00CE" modified="2006-07-11" version="1">MRFSMGMLDRMRAAFRGSSKRKGTGLELSRWASAPPRREVPALLAAYAEMPWLGTIVDTVGDAFADVTWRAFTRQDPTTRKSLVDVSLRRACGDVRRERLKSLVETGDAVELPDHPLLRLLADPNDYMTGRDFAKLFCLHYDLTGEFFAVVEELAGVPVGLWPVPPDCVLALPDLSKPKSERTYTVAAGGRTFLLPAASVIYVKRLNPADPLGRGIGIAYSLGDEVDTDEHAARFTKNAFFNNMLPGAVIAIEGFNESQAGPARAFKESLAREYGGPANAGRVMITSGRTTFARLDTPFRDMQLVDLRRFLMDFVRMVYRVPPEIVGDVTSSNKATSYAAREHLAEQATKPRAEVFLASMQKHLAPRFEDDVLLSYDSPVPADREHRLRVMGTLPSAFTFDEWRVEAGFKPHPERQGFAELLPGQKPNEPGETPTPVEGSSAEAHAEATKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD38</accession>
    <name>Q1DD38_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551295.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1175"/>
    <dbReference type="EnsemblBacteria" id="ABF86959">
        <property type="protein sequence ID" value="ABF86959"/>
        <property type="gene ID" value="MXAN_1175"/>
    </dbReference>
    <dbReference type="GeneID" id="41358625"/>
    <dbReference type="KEGG" id="mxa:MXAN_1175"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_5_1_7"/>
    <dbReference type="OMA" id="TWIFPNG"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="244" mass="26244" checksum="D3B1F8B179FEF17D" modified="2006-07-11" version="1">MERALRHVATRLGELDCHVIDALPEGATPELVVVLSHGLGAPATDLVPLGPELMAFQPALADRVRFVFPGGPMAWAHGGRAWFPLPDAVMRGEQRDWEQFARDVPPGMPAARRALMSTVDALCAAMKLPYGRIVLGGFSQGGMVSTDVALRLDEPPAGLCILSGTLTSEPEWRPRAQGRTGLPVFQAHGRYDPLLPLGSAERLRDLFVASGLTVDFHAYDMPHAIVTEELEALAAFLAARLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD44</accession>
    <name>Q1DD44_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88694">
        <property type="protein sequence ID" value="ABF88694"/>
        <property type="gene ID" value="MXAN_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1169"/>
    <dbReference type="HOGENOM" id="CLU_3292839_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="40" mass="4480" checksum="466CD81DB8F1CF1B" modified="2006-07-11" version="1">MRDAAIDGGDLEQQLEDFDVELFGAHVPLGWLFLGRPSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD92</accession>
    <name>Q1DD92_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1122"/>
    <dbReference type="EnsemblBacteria" id="ABF92392">
        <property type="protein sequence ID" value="ABF92392"/>
        <property type="gene ID" value="MXAN_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1122"/>
    <dbReference type="HOGENOM" id="CLU_1239071_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="23414" checksum="F4553470291E4F2E" modified="2006-07-11" version="1">MAQAPRRTPPQRATSGESRHDTGPMSVPAVPHPAYRRPALAHSIIRSARSSASRRRCTSWSTWSSVHASAMRSTSESAKRSTCAMLMQSRSSLVPAKRAASASIVRPSASSACTSAARATGCSYSAASRNWRRHGCDSQRTSDASLARFTGCVRFFFQNPPASTGLETFISITAPSPLRGPSTGMSDMDAAPSVPRVLLPSPPGAAAAGLVAAALYYGESAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM2</accession>
    <name>Q1DDM2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation efflux system protein CusC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551111.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0990"/>
    <dbReference type="TCDB" id="2.A.6.1.8">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91327">
        <property type="protein sequence ID" value="ABF91327"/>
        <property type="gene ID" value="MXAN_0990"/>
    </dbReference>
    <dbReference type="GeneID" id="41358446"/>
    <dbReference type="KEGG" id="mxa:MXAN_0990"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_15_0_7"/>
    <dbReference type="OMA" id="NEANWIP"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="456" mass="50802" checksum="DF1EDEF95AEE1ED4" modified="2006-07-11" version="1">MSPHGTWRRSATRAVLATGVAVWLGPGAAGANEQRYQSQLEAVARQAPEAQAPEPFTSASVLERAELVRQVLARNPSLEAAREAWRASLERYPRETALEDPMLTYEVAPLSITGSVPFGQVVGLSQQLPFPGKRGLRGEMALAEAQAMREDREALRLRLALMASTLFDDLFVVERSLDVTAEHLRLLGQLKKSAEAQYVTGRASQQDPLQAEVELSEVLREQVMFEAERERLRAQLNGLLHRAPQAPLPPLPEAMPAHTAESVPAERLQDEALRLRPELEGLRARLGGGEAAVRLAKRDYYPDVMVMGEYNSMWMDTPHQFMAGVTINIPLDFGKRKAAVREAESGLKRLRREEEQLISDIRVEVEQARSRAEEARRVVALFQERLIPAAKDQVSAARAGFESGKNSFQVLIEAERGLRRVELREQTALADVQRRRAELDKAMGHTPGLPRNGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW4</accession>
    <name>Q1DDW4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neurosporene hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551019.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0898"/>
    <dbReference type="EnsemblBacteria" id="ABF86935">
        <property type="protein sequence ID" value="ABF86935"/>
        <property type="gene ID" value="MXAN_0898"/>
    </dbReference>
    <dbReference type="GeneID" id="41358357"/>
    <dbReference type="KEGG" id="mxa:MXAN_0898"/>
    <dbReference type="eggNOG" id="COG5621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905880_0_0_7"/>
    <dbReference type="OMA" id="MLPFRMP"/>
    <dbReference type="OrthoDB" id="591394at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="34010" checksum="D7C50D1C38CAC9DD" modified="2006-07-11" version="1">MMRLAKLPALPDAAGTYRWFYADVTAGPYSAVCIFMLGSLFSPRYSVAARRGGRPLEHSAVNFALYHAGVRRLWVLSEYARAELDAPGRLRIGRSTLSYEGDGTVRMAVDDGTAPWGRPVRASLTLEPMTPVGEVVQLMPGLPHYWQALAPRSQARLEVSSLGIEASGLGYHDTNHGGELLGARLSGWHWARTHREDETVVDYHLPEGVAPLRVVAGARGVRCERGPTLVESRPTHITGWGLRVPSRLHAGNVVVGQPKLLESSPFYARLEARQGPLDSLGEVADFRRFHSPFIRWMAHFRTRMGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE75</accession>
    <name>Q1DE75_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0784"/>
    <dbReference type="EnsemblBacteria" id="ABF88114">
        <property type="protein sequence ID" value="ABF88114"/>
        <property type="gene ID" value="MXAN_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0784"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_9_0_7"/>
    <dbReference type="OMA" id="WLNYHHL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="33196" checksum="F5E86A17DEED1FE5" modified="2006-07-11" version="1">MDMSWLNYHHLLYFWTVARAGSIAKAGEELHLAQPTISSQLKLLEESLGHKLFERQGRKLVLTDVGRTVMRYADEIFRLGNELKNVVSGLPPGQQLRLNVGVLDVIPKLVAEQLLKPALEAGPSLRIICREGPLPQLLASLALHELDVVLADAPSSEPVSVRSFNHLLGKCGVSFFAAGKLVELRENFPQSLDGAPVLLPSVESSARRSMDLWFERKGLRPVIAGDFDDSALLQAFGQRGHGVFAMPSAIEAEVERQFNCSVIGRTDEIETCFYAITVERKIRHPAVVTIAEAARSHIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE94</accession>
    <name>Q1DE94_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0763"/>
    <dbReference type="EnsemblBacteria" id="ABF90108">
        <property type="protein sequence ID" value="ABF90108"/>
        <property type="gene ID" value="MXAN_0763"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_0763"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13191" checksum="CAAD14AE82E164E8" modified="2006-07-11" version="1">MQNVLVIDDDAFVLSVVRDILQSAGYGVVAVQSPAEAFNLDLSSVSAILCDYNMPDMNGSDVLTVMRELKDCRVPFIFLTGHEELDDLVSVAIRYGAELLPKPIQPVELVRLLVKQLASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE98</accession>
    <name>Q1DE98_MYXXD</name>
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        <submittedName>
            <fullName evidence="4">Type II/IV secretion system ATPase, TadA family</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">MXAN_0759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88515">
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        <property type="gene ID" value="MXAN_0759"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="71"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="648" mass="69884" checksum="B862B6E400911956" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF74</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_0429</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92426">
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        <property type="gene ID" value="MXAN_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0429"/>
    <dbReference type="HOGENOM" id="CLU_1097660_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="27235" checksum="36E4C88F9EE01221" modified="2006-07-11" version="1">MAKVPRPAHAATLWGDRIKRVPSVVPVAEVLVPNACDATYAMDGDRHWVHKRLLGADGLLAEALGLLLGQALGAPVPEGAVTGPPDDTTWLSEVIPDIQHWDRQLANFIVNYPDVGRLLALDAILLNDDRHEGNLVLQATAEHEYSRRAWGIDMANALAGRPTDFAAAGMNTPSIAKLVDGIPVTLIQEGAMLAAVQAQSLSTYLVKSMVMEACSLSREPRETEDVLLGALLSRMARAPELVAEYLEKVGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFF0</accession>
    <name>Q1DFF0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88544">
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    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0349"/>
    <dbReference type="HOGENOM" id="CLU_1072929_0_0_7"/>
    <dbReference type="OMA" id="WPRDGRW"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="239" mass="26424" checksum="E52AB595F08B0D8B" modified="2006-07-11" version="1">MWKPGVVEPSPAPRCGLTQRQRPLPPEEDDEPERPDGGALEPEDDFPLLLPPRPQPPLLELEPELLLELRLLLPELLPPRPQPLPLELELLELELLEPELLEPPLLPPRVFQPLPLLELPLLELPLLPELPLPQRLPLLLSRESSSFGAALFEVRPAGGLLHPLPELLLGAALFEVRPAGGLLQPLPELLPWPRDGRWLPPELEPRGVVQRVPPGGGRVPLYVLPGTTGRLEGRVAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFF1</accession>
    <name>Q1DFF1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550486.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0348"/>
    <dbReference type="EnsemblBacteria" id="ABF91725">
        <property type="protein sequence ID" value="ABF91725"/>
        <property type="gene ID" value="MXAN_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="41357846"/>
    <dbReference type="KEGG" id="mxa:MXAN_0348"/>
    <dbReference type="HOGENOM" id="CLU_965855_0_0_7"/>
    <dbReference type="OMA" id="GLFVYVH"/>
    <dbReference type="OrthoDB" id="1140432at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="327" mass="33687" checksum="5B2C647BDF28553B" modified="2006-07-11" version="1">MFFGQRGALQPHGQHHRGVDQGTDGAWGGLPPREAVESFPAMMRPLLMVPCAVLGLSLGCGPGDYTPDPGVQTDDAEAVDLDNLHIGVSGTVDLLPEARRLIEARGLPLPSLEGAPLTAAEPLRLAVNDANATFGTAPAAADGAFTVRDVAVREMHLSLAVGAEAAGLVPAHTVVYDAAFTGARPRTDIIGARVWALPDAFHDALSVAVGESAIRGHTDNRAATLRDAGFVLGRVVDASGHPVAGAKVAPDGEALAGRIYYPTADLQGVNQEGTGPDGLFVYVHSGADAEAFLLSVTGTDDYTPRNVGVAPGWGLVLTVHPGLHPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ0</accession>
    <name>Q1DFJ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550447.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0303"/>
    <dbReference type="EnsemblBacteria" id="ABF86494">
        <property type="protein sequence ID" value="ABF86494"/>
        <property type="gene ID" value="MXAN_0303"/>
    </dbReference>
    <dbReference type="GeneID" id="41357802"/>
    <dbReference type="KEGG" id="mxa:MXAN_0303"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_7"/>
    <dbReference type="OMA" id="MHRRDPA"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="36909" checksum="2F6FCF0AC5A3E011" modified="2006-07-11" version="1">METRKLGRQGPTVSALGLGCMGMSDFYAGRDDAESEATLLHALERGITFFDTADMYGSGANETLVGRVLKPHRANIVLATKFGIVRDPTDPQKRGINGRPEYVRQACEASLRRLGVDVIDLYYLHRLDVQTPIEDTVGAMAELVREGKVRFLGLSEVDADTLRRASKVHPITALQSEYSLWSREPEDGVLQACRELGVGFVPYSPLGRGFLTGQIKRFEDLAQDDYRRFSPRFQGENFTRNLELVGHIERLAKEKGCTPAQLALAWVLAQGKDLVPIPGTKRRKYLDENLGALEVTLTDQDVAAINAVAPPGVAAGGRYPPSMQSSLPKASQPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL2</accession>
    <name>Q1DFL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0280"/>
    <dbReference type="EnsemblBacteria" id="ABF90287">
        <property type="protein sequence ID" value="ABF90287"/>
        <property type="gene ID" value="MXAN_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0280"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_1_1_7"/>
    <dbReference type="OMA" id="DVHHNHV"/>
    <dbReference type="BRENDA" id="6.5.1.8">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="311"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="384" mass="40768" checksum="6D98BF8DCB2F3D2E" modified="2006-07-11" version="1">MPRLLPPAPGCRPILVWARALPPGAEKQLRHIASQPYVVEHVAAMPDLHVASGIAVGTVFATEHHVVPGALGGDLGCGVSAWRFPLTSGLPGRDVLERVLSQLAERIPVGDAVHRGRGLPLPPALESPPLSTQKLRHAWERLAPRHLATLGGGNHFLELDRDADGALWLLLHTGSRGVGAAIADHHGRVARALGEGGLPALDIHTAEGAACLADTQWACRFALANREAIAARALDVLEEALGVAADPTSVVDVHHNHVAQEEHGGRLLWVHRKGAVGLQSGQRGLIPGSMGTASYVAEGRGEPRAFRSCSHGAGRVLTRAEARARIRPAALEHVLRRVVYDKGRAAALVEEAPAAYRDITEVLEDEADLVRPLLRLTPLAVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG21</accession>
    <name>Q1DG21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550266.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0119"/>
    <dbReference type="EnsemblBacteria" id="ABF89431">
        <property type="protein sequence ID" value="ABF89431"/>
        <property type="gene ID" value="MXAN_0119"/>
    </dbReference>
    <dbReference type="GeneID" id="41357624"/>
    <dbReference type="KEGG" id="mxa:MXAN_0119"/>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041667_0_0_7"/>
    <dbReference type="OMA" id="HERIYNR"/>
    <dbReference type="OrthoDB" id="1766956at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032871">
        <property type="entry name" value="AHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14412">
        <property type="entry name" value="AHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="48254" checksum="943CAAFCB3A07CA2" modified="2006-07-11" version="1">MRAHAVIWLVLALAVTGCSTTRLVRLDTGDGHLIVHTPFAEEGDGPVELADDEFEETMVALARGVRPFSNPLREARQRFGVPERSGVYLYEGHGPRLIPQDEGKDPGGPHLLEVYADDELTRAYGRWCERKSQPGDCLRLLSEGPLLASDGKYSLAMAIAMDSVWEETAEALEDMADPQALLATVSASVSMYLLLWSLPEPVSKGLAALLTASAIAYLGVDTVWRILDGWMALVREVDRATTFEQLSEAGEAYGEVLGENAARVFVMLATAAISNTAGLATQSSRLPGSAQAALAVETQAGYQYLTIGSVQSVAMTAEGFTVALAPNAVAMAAQGMSGGRSENHHLATNKNGVSTVRGGPWTPRFKRIFKKAGMELEDPENIVPVKGHKGPHPQRYHERVYARLEEATKGCRKMTECREALVNELRQLAKEAGAPGSGLNKLLTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB5</accession>
    <name>Q1DGB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0025"/>
    <dbReference type="EnsemblBacteria" id="ABF89578">
        <property type="protein sequence ID" value="ABF89578"/>
        <property type="gene ID" value="MXAN_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0025"/>
    <dbReference type="HOGENOM" id="CLU_105840_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="228" mass="25973" checksum="B3163C861C3B7824" modified="2006-07-11" version="1">MDALSCHWSSNRRRYGRDARMSLRWAKVAMLLTACGGAGYRYAGRDVYFGPDGGQVWVRGPWPAIQPSRNVDDVIDQLCPIIMEMDGAREKDYGQEYCGVLYSLGDGVFYASYPSPLGEMQRIGPNKRKSCTSPRYVRDERGRAVGIADYHSHPWAPSPLTPEDRWEKNQRWLIRIQFDTDCHVMKLVPHANEPQPGEVYLRMGRAWELIGIIKPEHKPFGIVTDVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH3</accession>
    <name>Q1CVH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase, M16B family member</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557399.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7497"/>
    <dbReference type="EnsemblBacteria" id="ABF88459">
        <property type="protein sequence ID" value="ABF88459"/>
        <property type="gene ID" value="MXAN_7497"/>
    </dbReference>
    <dbReference type="GeneID" id="41364631"/>
    <dbReference type="KEGG" id="mxa:MXAN_7497"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007487_1_1_7"/>
    <dbReference type="OMA" id="LAWVNKY"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188093" evidence="4">
        <location>
            <begin position="34"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="5">
        <location>
            <begin position="79"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="6">
        <location>
            <begin position="234"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="5">
        <location>
            <begin position="542"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="6">
        <location>
            <begin position="690"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="953" mass="105021" checksum="42F1B9F5766EDA4D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ3</accession>
    <name>Q1CVJ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7477"/>
    <dbReference type="EnsemblBacteria" id="ABF92612">
        <property type="protein sequence ID" value="ABF92612"/>
        <property type="gene ID" value="MXAN_7477"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7477"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_7"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="31231" checksum="0DF45C6717651321" modified="2006-07-11" version="1">MHCITRGALAYGRGERGWATVGRIICISNQKGGVGKTTTAINLAASLASAERRTLLVDMDPQGNAGSGLGIKQDNITGTIYEALLNDRPIQELLHPTELRYLQVVPATPDLTGAEVELVNQDNREFRLRDALRPLAAEYDYIIIDCPPSLGLLTLNALAAADSVLIPLQCEYYALEGLSQLTHTIDLVKQGLNPDLKMEGILLTMFDSRANIAHQVVEEVRGYFKKQVFEVIVPRNVRLSECPSFGKPIILYDIKSKGCESYLALGRELMKRDTPKSPRRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVN8</accession>
    <name>Q1CVN8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase orfB, IS5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0577</name>
        <name evidence="5" type="ORF">MXAN_4917</name>
        <name evidence="3" type="ORF">MXAN_6267</name>
        <name evidence="2" type="ORF">MXAN_7430</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0577"/>
    <dbReference type="EnsemblBacteria" id="ABF87260">
        <property type="protein sequence ID" value="ABF87260"/>
        <property type="gene ID" value="MXAN_7430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87621">
        <property type="protein sequence ID" value="ABF87621"/>
        <property type="gene ID" value="MXAN_6267"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88443">
        <property type="protein sequence ID" value="ABF88443"/>
        <property type="gene ID" value="MXAN_0577"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89680">
        <property type="protein sequence ID" value="ABF89680"/>
        <property type="gene ID" value="MXAN_4917"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0577"/>
    <dbReference type="KEGG" id="mxa:MXAN_4917"/>
    <dbReference type="KEGG" id="mxa:MXAN_6267"/>
    <dbReference type="KEGG" id="mxa:MXAN_7430"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_9_3_7"/>
    <dbReference type="OMA" id="VADIECA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="99" mass="11542" checksum="60D7997E5FE1A3E5" modified="2006-07-11" version="1">MAEELMVHAEGAAFIADTGYDADRIRANVRKLGMKPVIHSNPSRKRALPLDRTLYRMRYRVECFFHDLKRFRAVATRYDKTATSYLAVLHVASMLLWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS8</accession>
    <name>Q1CVS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SCO1/SenC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557300.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7388"/>
    <dbReference type="EnsemblBacteria" id="ABF89175">
        <property type="protein sequence ID" value="ABF89175"/>
        <property type="gene ID" value="MXAN_7388"/>
    </dbReference>
    <dbReference type="GeneID" id="41364547"/>
    <dbReference type="KEGG" id="mxa:MXAN_7388"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_2_1_7"/>
    <dbReference type="OMA" id="MIHTENF"/>
    <dbReference type="OrthoDB" id="1994201at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="87"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="28091" checksum="1CBD25DD2456CBA9" modified="2006-07-11" version="1">MTQGMGRHRLVTSSPPSSQDVAPQRPRLCDSKGSVTSGAMSADSVLPAPRARLTQRPGFWAGVAVAALGVTATMGAMLIRGQSGEPLPQLGALPDFTFTRHDGQPFGSTQLRGKPFVANFIFTRCPTICPAFTRKMVGVQDATASHGAGLQLVSFSVDPKYDTPERLTEYGERHGADFSRWSFLTGDYEQLKETIVQGFKVSMGREPGAPEDDLLSIFHGTHFVLVDDAGQIRGYYDSADSDSTERLIRDTRRLAQTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVT5</accession>
    <name>Q1CVT5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_7381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557293.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7381"/>
    <dbReference type="EnsemblBacteria" id="ABF92540">
        <property type="protein sequence ID" value="ABF92540"/>
        <property type="gene ID" value="MXAN_7381"/>
    </dbReference>
    <dbReference type="GeneID" id="41364540"/>
    <dbReference type="KEGG" id="mxa:MXAN_7381"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022427_0_0_7"/>
    <dbReference type="OMA" id="CPCHAST"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188100" evidence="8">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="194"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="28354" checksum="E3F29C60E7B3BB83" modified="2006-07-11" version="1">MSSTRRGFLKGILGTGAASAAATTLPGCAPDINPAPVTDVTASEQGTVDILVSRYPDLEPVGGALTVRVSGEQVPLLVVHSKDDGAPNDFSVLSSLCTHVGCPLGFDGKDVICPCHLSRFSATDGAVLQRPATVPLQTFAAEYNPNTGVLRINLRAGQSDFPAAVNGQVVFPLSQFPQLRDVGGSVTGVPSGYGKRIFVFRLQDGALSAVDSVCTHAFCEVNYREQEADLFCACHASIFTRDGAVTQGPATRPLKKFTVSETGDSVVLTGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVX4</accession>
    <name>Q1CVX4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557255.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7336"/>
    <dbReference type="EnsemblBacteria" id="ABF88072">
        <property type="protein sequence ID" value="ABF88072"/>
        <property type="gene ID" value="MXAN_7336"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7336"/>
    <dbReference type="HOGENOM" id="CLU_155686_0_0_7"/>
    <dbReference type="OMA" id="CELHNRY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="114" mass="12635" checksum="33683630C8423095" modified="2006-07-11" version="1">MRRVQLSVHRTVGEARLLAGALEAMGVAVEVRGEALAPLSGEIPSAETWIELWVEPQDLEHAKGLLAELLENQEHAERSVECPRCREENPGNFELCWSCGLELPSGLRPRLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ3</accession>
    <name>Q1CVZ3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557236.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89074">
        <property type="protein sequence ID" value="ABF89074"/>
        <property type="gene ID" value="MXAN_7317"/>
    </dbReference>
    <dbReference type="GeneID" id="41364480"/>
    <dbReference type="KEGG" id="mxa:MXAN_7317"/>
    <dbReference type="eggNOG" id="COG3047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092808_0_0_7"/>
    <dbReference type="OMA" id="IWLELGY"/>
    <dbReference type="OrthoDB" id="1345476at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187692" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="25676" checksum="4CE34D652D215AED" modified="2006-07-11" version="1">MTTPRTLWKLTTLSLMLSAPAFAADEVEQAQEDRGFALGLRAGYGVPLGHAAGSDLGETPKMSEVFKSAIPLQVEAGYFFNSNVYLGAYFQYAPVLIAEDCDSDVSCSANQMRFGINASYHFRAGEKLMPWMGLGIGYEMLKLNVSSSEDGVEATIGTGVRGIEFAALQAGADYRINDTFSIGPYLSLAAGVYQSSTSSIEMKNVPIIGDVSESESESIDNKTVHAWLSGGVRMQFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW15</accession>
    <name>Q1CW15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sugar ABC transporter, periplasmic sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557214.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7295"/>
    <dbReference type="EnsemblBacteria" id="ABF86062">
        <property type="protein sequence ID" value="ABF86062"/>
        <property type="gene ID" value="MXAN_7295"/>
    </dbReference>
    <dbReference type="GeneID" id="41364458"/>
    <dbReference type="KEGG" id="mxa:MXAN_7295"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_1_7"/>
    <dbReference type="OMA" id="PFWANTQ"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="47177" checksum="0651DCD153DE35B5" modified="2006-07-11" version="1">MRRVSSIVLALSLVVGLGVWGCRRQDAAGEAGGRTRLVFKYQPLWGPPEPFRELLARFERENPGVELVTEALPNASDLAHQFFLTSLEGGARDFDVLVVDVVWVPEFARAGWIADLSAEFPPERLREDFFPGPVEAVVVEGRTYAVPWYLDVGLLYYRTDLVPRAPRTYAELERFAREAMAKTPGLQGYVWQGRQYEGLSCNVYEALWGHGGRALSEDGRVLLDDAPAREALAYLRGLVERGVSPATVTGFSEEESRRVFQEGRAVFMRNWPYAWNEAQKPDSPIRGKVGIAPLPTVSGEPGSGALGGWQLAVNAHVSPERRKLAARLIAHLTSPEANRVLALNYARNPPRPAVYQDARLREEAPFIAGLLPMVERAKPRPVTPYYNLISDVLQSEFSAAVAGLRTPEAALKRAQRQVDHLTGEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH2</accession>
    <name>Q1CWH2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein CinA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557057.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7138"/>
    <dbReference type="EnsemblBacteria" id="ABF90486">
        <property type="protein sequence ID" value="ABF90486"/>
        <property type="gene ID" value="MXAN_7138"/>
    </dbReference>
    <dbReference type="GeneID" id="41364312"/>
    <dbReference type="KEGG" id="mxa:MXAN_7138"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_1_7"/>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="17805" checksum="5AB2765F030AD901" modified="2006-07-11" version="1">MTEASLEDLARQALERCRAAGVRLALVEACTGGLLGATLTEVPGASAVVERGFIPYSYESKVEQLGVPLALLQAHGSVSAEAVEAMAHGALARSTADWVLVETGIAGPGGGTPQKPVGLAYLAVLQRGGQATVERHVFTGDRGQIRRAIVGRSLALLVERLGVGDLPPTVSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI7</accession>
    <name>Q1CWI7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557042.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7123"/>
    <dbReference type="EnsemblBacteria" id="ABF88288">
        <property type="protein sequence ID" value="ABF88288"/>
        <property type="gene ID" value="MXAN_7123"/>
    </dbReference>
    <dbReference type="GeneID" id="41364297"/>
    <dbReference type="KEGG" id="mxa:MXAN_7123"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577247_0_0_7"/>
    <dbReference type="OMA" id="CKAHAHV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="316"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="533" mass="58552" checksum="CE015C8222836632" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI5</accession>
    <name>GLPK_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol kinase</fullName>
            <ecNumber evidence="1">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycerokinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpK</name>
        <name type="ordered locus">MXAN_6771</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556696.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CXI5"/>
    <dbReference type="SMR" id="Q1CXI5"/>
    <dbReference type="STRING" id="246197.MXAN_6771"/>
    <dbReference type="PRIDE" id="Q1CXI5"/>
    <dbReference type="EnsemblBacteria" id="ABF91454">
        <property type="protein sequence ID" value="ABF91454"/>
        <property type="gene ID" value="MXAN_6771"/>
    </dbReference>
    <dbReference type="GeneID" id="41363962"/>
    <dbReference type="KEGG" id="mxa:MXAN_6771"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_7"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000020750" description="Glycerol kinase">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="414"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <sequence length="496" mass="53740" checksum="B12DE6E765C71070" modified="2006-07-11" version="1">MPKAKYVLALDQGTTGTHVSILDTKLQVVGRSYKEFTQHFPKPSWVEHDLDEIWASSEWCIARALKSAGLRGKDIAAIGITNQRETTGLWMRGSGQPLSHAIVWQDRRTAEQCRRLKEQGVEPRVREVTGLVVDPYFSGTKLTWMFDHLKGARAKAEKGDVCFGTIDTWLVYKLTGGAAHVTDVSNASRTLLMDLTTLQWSDEMRAMLSVPAACLPQIRGSAEVYGTTRGMRSLPDGIPVAGMAGDQQAALFGQACFEPGESKCTYGTGAFLLMNTGSEPVRSSAGLLTTVAWRLGGTGTTTYALEGSSFIAGAAVQWMRDGLKVIKRAPDIEALAASVKDSGDVVFVPALAGLGAPHWRPEARGLFAGIDRSTTVAHMARAVLEGIALQIHDLAEAMRRDSGRDIPVFKADGGAAANNLLMQFQADVLGVPLVRPRNLETTSLGAAFLGGLGAGIWDSPEAIRRAWKAEKTFKPKMKPDARERHLAKWKRAVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXS8</accession>
    <name>Q1CXS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6678"/>
    <dbReference type="EnsemblBacteria" id="ABF86448">
        <property type="protein sequence ID" value="ABF86448"/>
        <property type="gene ID" value="MXAN_6678"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6678"/>
    <dbReference type="HOGENOM" id="CLU_3082157_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="52" mass="5719" checksum="DDD4D4856A721944" modified="2006-07-11" version="1">MSEGAAPWTLACMSKPVGKQEWFRGVEAFQASGLTQQEFSRQSGLRLSTLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF0</accession>
    <name>Q1CYF0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B12 binding/radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556381.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CYF0"/>
    <dbReference type="STRING" id="246197.MXAN_6449"/>
    <dbReference type="EnsemblBacteria" id="ABF88423">
        <property type="protein sequence ID" value="ABF88423"/>
        <property type="gene ID" value="MXAN_6449"/>
    </dbReference>
    <dbReference type="GeneID" id="41363656"/>
    <dbReference type="KEGG" id="mxa:MXAN_6449"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042889_0_0_7"/>
    <dbReference type="OMA" id="AHYFMPL"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023980">
        <property type="entry name" value="CHP04013_B12-bd/rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04013">
        <property type="entry name" value="B12_SAM_MJ_1487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="171"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="46904" checksum="73B1EECA62770F87" modified="2006-07-11" version="1">MQPSRRVSLVLSYQYPGKYAFTVLAGAVESDPALADVTLHFPRSRETLLDTIRERVDAGDTVVAAWSFYSASFAPAAEELAWVRERLEGRDVLCIAGGVHATAETLQTLQAGFDLVAVGEGEYSLRALLGRVLRGEVPRETHGVAYLKDGKLVQHGRGEGVQLDDFPPFAARNGQYGAIEITRGCIYACRFCQTPFMSKARFRHRSVANVAHWARELRRSGRRDIRFITPTSMSYGTADESVNLDAVEALLAAVKEAMAPDGRVYYGTFPSEVRPEHVTPEALELLKRYVHNDNLIIGGQSGSERILQSTRRGHDVETVVRATRIAVECGFVPNVDFILGLPGEEPEDVDATVALMEKLAGLGARVHGHTFMPLPGTPFRDAPPGSVDEATQRKLDRLASQGRLYGHWKQQVALAEGIASRRRPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYL7</accession>
    <name>Q1CYL7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556314.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6382"/>
    <dbReference type="EnsemblBacteria" id="ABF91571">
        <property type="protein sequence ID" value="ABF91571"/>
        <property type="gene ID" value="MXAN_6382"/>
    </dbReference>
    <dbReference type="GeneID" id="41363593"/>
    <dbReference type="KEGG" id="mxa:MXAN_6382"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530919_0_0_7"/>
    <dbReference type="OMA" id="MNGTWVN"/>
    <dbReference type="OrthoDB" id="1355929at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="85"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="19567" checksum="C4AAD91A6BFFB511" modified="2006-07-11" version="1">MPSVKQLRPFALATLEAFLEASGRVVLVQQPPEPVFQQVAMRLGEARTVGMAHRTRLVDRLFVMLRGFDALEVHFLRPETEGEEFSVGRIEGCSLVVPDPSVSKLHAILRWHAQAGDCSVRDQGSMNGTWVNASSLGPDQDRMLNDGDALAFGDAQFLYLRTETLHAHLRMASPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYR6</accession>
    <name>Q1CYR6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6332"/>
    <dbReference type="EnsemblBacteria" id="ABF89360">
        <property type="protein sequence ID" value="ABF89360"/>
        <property type="gene ID" value="MXAN_6332"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6332"/>
    <dbReference type="HOGENOM" id="CLU_1968164_0_0_7"/>
    <dbReference type="OMA" id="THCTLTI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="13911" checksum="F14B651AB52F81DB" modified="2006-07-11" version="1">MRSSWPRSTRVEAEGVMVGTAAGPWLPVPPLWRWMTVSTSEGGGDTTMSRKTMDCRKAPSDTHCTLTISGEEDEVFQAAISHAVSAHGHEDSGELREMVRGMLEDEAPEASMGQPMSMQEPQQPSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ15</accession>
    <name>Q1CZ15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6227"/>
    <dbReference type="EnsemblBacteria" id="ABF87692">
        <property type="protein sequence ID" value="ABF87692"/>
        <property type="gene ID" value="MXAN_6227"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6227"/>
    <dbReference type="eggNOG" id="ENOG50338ZF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1667926_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="17617" checksum="5729BF37008F87B1" modified="2006-07-11" version="1">MPRMRGHRNWAGTSVIAVTLWLACGVAMSGCGRGKERAALATKLEQRIRSATEVGDAFHLSEVTDFDWDTLHVFTPYVVAEEVRQSLGNDWSGARDIYESECLLVFVKEGRVVMDLEFPRMKGDFSAMKKYRFSRDEARFAAPKDGRRLTHAMDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZG7</accession>
    <name>Q1CZG7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anthranilate synthase, glutamine amidotransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556020.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6071"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="ABF90830">
        <property type="protein sequence ID" value="ABF90830"/>
        <property type="gene ID" value="MXAN_6071"/>
    </dbReference>
    <dbReference type="GeneID" id="41363307"/>
    <dbReference type="KEGG" id="mxa:MXAN_6071"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_7"/>
    <dbReference type="OMA" id="MHGIVDT"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="19624" checksum="1F21E3C9A53BF6D9" modified="2006-07-11" version="1">MILVIDNYDSFTFNLVQLLYTLGAEVKVVRNDDLDAEGVAASGASHLVISPGPCTPHEAGVSVAAIAQSRVPVLGVCLGHQSIGAAFGGKVVRAPEPVHGKAAHIRHGGTGLFAGLSEGFAAARYHSLIVEAPSLPAELEATAWSQDGLIMALRHRERPVVGVQFHPESVLTPEGPALVRNFLEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR0</accession>
    <name>Q1CZR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphonate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555927.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5978"/>
    <dbReference type="EnsemblBacteria" id="ABF87716">
        <property type="protein sequence ID" value="ABF87716"/>
        <property type="gene ID" value="MXAN_5978"/>
    </dbReference>
    <dbReference type="GeneID" id="41363217"/>
    <dbReference type="KEGG" id="mxa:MXAN_5978"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014993_0_0_7"/>
    <dbReference type="OMA" id="YIYPSLW"/>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="29257" checksum="B2B2694995DF87B6" modified="2006-07-11" version="1">MTLQAPSTPRHSFRFGLPPSLGSESARERADRLASFLQRALGKLVEVSVASSYETLAKDLLSGRADAAWAPPFVCARMEAMGVRVVVRGVRRGMSSYRSALVCRAGAGLTVERLKGTTATWVDRDSVAGYLLPTAYLKTQGLEPTRAFFAQHFAGSYQGALESVLDGKADVTSVFCPPASTGLTFATGVEDVLGAGAGRRFELIAYTDEAPNDGVPVAMGLQPQLVSSLESTLLSLQTSPDGQALLKDIFNAERFESAPRMGYRALYRVALASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D014</accession>
    <name>Q1D014_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555823.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5872"/>
    <dbReference type="EnsemblBacteria" id="ABF88348">
        <property type="protein sequence ID" value="ABF88348"/>
        <property type="gene ID" value="MXAN_5872"/>
    </dbReference>
    <dbReference type="GeneID" id="41363111"/>
    <dbReference type="KEGG" id="mxa:MXAN_5872"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1609051_0_0_7"/>
    <dbReference type="OMA" id="HYHRERR"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="170" mass="18704" checksum="F128606D41FCCF78" modified="2006-07-11" version="1">MPPDPPDASTVSGHLQGLARRIRTLRERRGLTQEDFAARCGISVSFASLLERGERSPSYETLLQVAAALQLPLWELLRLEDTQDAGVHRLEAFVRGRGLARVDVDRLLSVAEVMFNEPTRATEDIQAVRPEPARCGEPGCEKPVLARGLCAAHYHRERRRKAASPGTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J1</accession>
    <name>Q1D0J1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5694"/>
    <dbReference type="EnsemblBacteria" id="ABF87681">
        <property type="protein sequence ID" value="ABF87681"/>
        <property type="gene ID" value="MXAN_5694"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5694"/>
    <dbReference type="eggNOG" id="COG3703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116235_0_0_7"/>
    <dbReference type="OMA" id="WGGKVAR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="21450" checksum="115A2C4238E890DC" modified="2006-07-11" version="1">MLPYAQALVLGARPAETWDMADGPTAPRSWFAYSLDLAPVIAHERLPGLPPIPDVLEGELAEALDVDVVYDVASAAWGGKVARLVDAPGHKLPGMLRRVPADAWDALVRLESAMASATEVRQVKVRTFTGAVLSAHVFTPTAPATPAQGLVSEAFLVTLALSAEEAGLSPDHVERLQAEARIVQALQKAGPEALNPSKAPGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J2</accession>
    <name>Q1D0J2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA/RNA non-specific endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555645.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5693"/>
    <dbReference type="EnsemblBacteria" id="ABF92115">
        <property type="protein sequence ID" value="ABF92115"/>
        <property type="gene ID" value="MXAN_5693"/>
    </dbReference>
    <dbReference type="GeneID" id="41362938"/>
    <dbReference type="KEGG" id="mxa:MXAN_5693"/>
    <dbReference type="eggNOG" id="COG1864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_655244_0_0_7"/>
    <dbReference type="OMA" id="GHMKPAE"/>
    <dbReference type="OrthoDB" id="359581at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="Extracellular_endonuc_su_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="PTHR13966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease_NS" evidence="3">
        <location>
            <begin position="233"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="NUC" evidence="2">
        <location>
            <begin position="234"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="483" mass="52248" checksum="010E60476EC19D98" modified="2006-07-11" version="1">MARRTADDEGRGSTSCFTSSAPRTFRMTLRPTTTRAVPPRPASAASPLNAVTTPGGSWRRSTAREVPINELQEKFGWKDDSWQVGLMQAADAAGSKTRGGNGQVSAAELERYLAAPEDGQYLTSTALQQKRSSLDAKLAQGNGSAVGVDAFESGWQATVARRADLLGGNGDGQLSAEELDAFIQASKAGKHADTRWVPDQQMAAFQSRVAEAAGELDPMRPAGALGSEGLSLVKEYSRLALDQGANVPTFVSYMLSASDIQETPATVSRLESTFVRDPELGRTGVTDSDYTRTGFDRGHMKPAEDSPTQEAMNESHLMTNIAPQHGNHNQQVWRTLEQGVSGLVNSQGGKAYILTGNLYLDDKGQPLPPEKRETTGAGERRIAVPTHNFKTVLHELPNGSLTMYAYLVPNTKDGPSKKEDILPLLDSHRVPVDRIEELLGQDLYANLPKRVQDKLEKGTSAEGVFQRNSLYFAASLFRFAPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1J4</accession>
    <name>Q1D1J4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555294.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90519">
        <property type="protein sequence ID" value="ABF90519"/>
        <property type="gene ID" value="MXAN_5329"/>
    </dbReference>
    <dbReference type="GeneID" id="41362598"/>
    <dbReference type="KEGG" id="mxa:MXAN_5329"/>
    <dbReference type="eggNOG" id="ENOG5032DVU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150889_0_0_7"/>
    <dbReference type="OMA" id="LEYRWYV"/>
    <dbReference type="OrthoDB" id="1251635at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="29550" checksum="CCF92C980DB84D21" modified="2006-07-11" version="1">MVLIVHERWRPSGLTNVATLPTFMTLSDALLLLERCFTGLAEGAPRLREQEDARFALRPSAVWLEYRWYVQERGMAEVFLKWPRTSTGQSAAAEATVLRVHLLGVSPTLSQRAGQLLVGGTPSRDRIMDLFGDDGVRRECVCLGRTNVTVEHWEPQPGPRPLLDDARFTSLAEVLEAPDSTPEVRHEAVQRLADERSPRVVAVLLALVARKHSLMALRVLSEWGVVGAREALQRDLAQVRPDNPADLWTLTALERRLQAWAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D224</accession>
    <name>Q1D224_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555117.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5146"/>
    <dbReference type="EnsemblBacteria" id="ABF92898">
        <property type="protein sequence ID" value="ABF92898"/>
        <property type="gene ID" value="MXAN_5146"/>
    </dbReference>
    <dbReference type="GeneID" id="41362428"/>
    <dbReference type="KEGG" id="mxa:MXAN_5146"/>
    <dbReference type="eggNOG" id="ENOG5030WWU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065989_0_0_7"/>
    <dbReference type="OMA" id="LPECRAT"/>
    <dbReference type="OrthoDB" id="973352at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046181">
        <property type="entry name" value="DUF6209"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19714">
        <property type="entry name" value="DUF6209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="34148" checksum="A758ED3C9C507FEB" modified="2006-07-11" version="1">MGLRRLFTGRARCSISPPSAARLSSDSPLNMAFQPIWISGEAIDLMRGSGLPPSAPSAARKERILVRRFLPSLLPLVLVASTAAAQTTPTSITFDGDWNETPSVELIPVGGQVVVNYDISRLPQCRGTTSSGNPTWTITGHVQVNRGPVVSFWVAGHAPDGNSSQRVLHLPAGLSGALVMWFDISSQGCQAWDSNHGSNYHFAIGAPTLSFNANWDEVIAGTLRAGQQLIVNYDEARLPECRATYNGPAWSIVAQYRFDNGPIQETVVTGSGRSEPTAITAPAGARHLEMWFRNTDRSSCVSYDSNYGSNYHFAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D257</accession>
    <name>Q1D257_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555086.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5112"/>
    <dbReference type="EnsemblBacteria" id="ABF92188">
        <property type="protein sequence ID" value="ABF92188"/>
        <property type="gene ID" value="MXAN_5112"/>
    </dbReference>
    <dbReference type="GeneID" id="41362396"/>
    <dbReference type="KEGG" id="mxa:MXAN_5112"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_1_7"/>
    <dbReference type="OMA" id="AGMMMNY"/>
    <dbReference type="OrthoDB" id="1194802at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="7"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="536" mass="57868" checksum="DA0D7D7BF6486F7B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D8</accession>
    <name>Q1D2D8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux transporter, HAE1 family, outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555006.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5030"/>
    <dbReference type="EnsemblBacteria" id="ABF87459">
        <property type="protein sequence ID" value="ABF87459"/>
        <property type="gene ID" value="MXAN_5030"/>
    </dbReference>
    <dbReference type="GeneID" id="41362315"/>
    <dbReference type="KEGG" id="mxa:MXAN_5030"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539582_0_0_7"/>
    <dbReference type="OMA" id="FLTEARC"/>
    <dbReference type="OrthoDB" id="591860at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="462" mass="48825" checksum="32E164679E250B36" modified="2006-07-11" version="1">MASPSVILLALVAASTLTEPSPSIPAPVPFQPKVEDAMLTPVAPAQRQVTTWDEALALVRERSTNLRSAEAGVERAAGRSRQALAALLPNARLSSSVGVDLLNPDLPVGAGGTPLVGIGGGDTRGPSTPLLTATANVTQSLVDVSAWRGRASAVAAEEGAAATLGETRRLLTRGLAQVLVSTVAAERAAEINRVGLRQALERFALAQRTYELGAGNQLDVVRVEQDVAVARSALVAGDEQLRRSREALGLAVGFGNAVGVSRDFNLQGLVNETQRACTPLKDMNERTDLVASRAQLESARDSRQQATAGYLPTLGLSSTAVGLTTDPGFGRVAIWSVSAVLSVPIWEGGLRGGLIREREGLERQAAEALESTRRDVSIQVAQARRAVEVAEALVTTAVASRDLADRTDRLTRRSFEVGRGSSLELVQSGAALRQAELTLVLREFELVQARLDAFLTEARCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2U8</accession>
    <name>Q1D2U8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA domain/TonB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF90228">
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        <property type="gene ID" value="MXAN_4867"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0810">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026767_0_0_7"/>
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    <dbReference type="OrthoDB" id="263730at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="390"/>
            <end position="432"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="640" mass="66439" checksum="E8AD69AACF77CE10" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D374</accession>
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
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                <person name="Miller N."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DK1622</strain>
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        <property type="gene ID" value="MXAN_4737"/>
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    <dbReference type="KEGG" id="mxa:MXAN_4737"/>
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    <dbReference type="OrthoDB" id="1124669at2"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <begin position="537"/>
            <end position="558"/>
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        <location>
            <begin position="591"/>
            <end position="751"/>
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    </feature>
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            <begin position="139"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="837" mass="91037" checksum="9C33E41D6831ED5B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M1</accession>
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        <recommendedName>
            <fullName evidence="1">Methyltransf_30 domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="30983" checksum="AA36FDA5B00A6324" modified="2006-07-11" version="1">MSTAPDANPRDGDFELITLRNGARAVRHLGHGEVMHPSVGPWQEALRLYVEQARLADRLRQPGPPLVIHDVGLGAATNAVAALTCARSLGAEQRRLLEVVSFEVDLAPLRLALADAEGFPFLQPFRDAAETLMRDGVWEAEGLRWRLLLGDAVPHLDGTLPVADLVYFDPFSPASNPEMWTEAVLARVRRHCREDGEGTLLLTYSAATPTRVTLLLAGFFVGAGVSTGTKGETTVGATRRESLEAPLGERWLERWKRSSSRAPHGGQLTPDIEARVLAHPQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
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    </gene>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Kaiser D."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92751">
        <property type="protein sequence ID" value="ABF92751"/>
        <property type="gene ID" value="MXAN_4569"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4569"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656927_0_0_7"/>
    <dbReference type="OMA" id="STKHWYF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="182"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="367" mass="38725" checksum="5DF67DE1B0781F79" modified="2006-07-11" version="1">MLVLNDGREVQAVPPFAPPATSFQPGFHQALRASHSTGSVTTFRMRVPVARDGGRIRVTFRAGNGSMTLVRATVAQAGANGALASTPVKLSFDGAEGFTVDARSRKTSDPVDFPVAFRDELAITFEARGALAASTISAFPGSFARVGNHALVTGALGGTLFDRAVGVATVDVEGSTGRAFVAIGDSITEGYVDTKNDTRNAWPAKVEAALGVPVVNAGVSGQGFYDALAHLDGEVLALQGITDCIVLLGTNDLGDKDSLSLIQARMNTMLGRLAPFCRTWVSTLLPKEKSNYAPYEVVKSQRPELNTWLRSGAAGPDIIDLEAVTRQPANVHLFLDGLDVDGIHPSVEGHRVMADEVTRVLREEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q5</accession>
    <name>Q1D3Q5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4550"/>
    <dbReference type="EnsemblBacteria" id="ABF91738">
        <property type="protein sequence ID" value="ABF91738"/>
        <property type="gene ID" value="MXAN_4550"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4550"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_5_7"/>
    <dbReference type="OMA" id="YMLAFDD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="37764" checksum="B3209AB5DDBA53CE" modified="2006-07-11" version="1">MKPGADILILGAGVVGLSAARRLSALGASVTVLDAVDPGGRGSRAAAGVAIPSVRLFDDPVMLAFARAGRGTLAEDLASLPGGDQLRRGNGILRVVADAKARDALAAKAVADAEGLGTWRDAASLVSLEPALEGTPLFGAFETDQGHLVDTDGYVDALLKAAAHVGVRLRLGVAARSVSESSTGVEVQTEGETLRADQLLVCAGPWSAGVEGLPSLPLKPLRGQMLVVHQPGLHLTRVVSGPSYLAPWRSGEIVVGATEEDAGFVEQVTPAGLLHLSATVAKLAPRLRDARFVRAWAGLRAATPDGHPYIGRHPGTRRTYVATGLGGQGILTGAHTGALLAELVAHGHCAAAEPFSPARITDGSPLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3V4</accession>
    <name>Q1D3V4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554496.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4500"/>
    <dbReference type="EnsemblBacteria" id="ABF92592">
        <property type="protein sequence ID" value="ABF92592"/>
        <property type="gene ID" value="MXAN_4500"/>
    </dbReference>
    <dbReference type="GeneID" id="41361807"/>
    <dbReference type="KEGG" id="mxa:MXAN_4500"/>
    <dbReference type="eggNOG" id="COG3500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061954_0_0_7"/>
    <dbReference type="OMA" id="MAIAYIT"/>
    <dbReference type="OrthoDB" id="1278199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="358" mass="39072" checksum="300166BF570B7803" modified="2006-07-11" version="1">MTDATSQPEHHRPTVRIFGKADARVTGLVSSMRLEEAEGGLCSLELRFEAIARYADTVAEQVFEDEQLLRLGAPIGIYTGPESAPQEIFRGVITGIEAVFSHDSAPEFVVLAEDALQKARLARRTHVHSDLKLAELAEKLARDLGLTPIIPGLRESLGLQVQWNESDLAFVRRLLATRDADLQVTGDELHVSARSAVRRGILELTLYSELRRVRVTADLAHQATQVTCTGWNAIQGARVSGQSSGSRPGPGAGRTGAELLQQTLGPRTEHLGSLPVSTSDEATAIARAAFDARARRFVRIDATAEGTPALRVGTHVRLRGLSARFDNTYYVVRASHRYDTLHGYETDFEAECAFLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Y1</accession>
    <name>Q1D3Y1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87419">
        <property type="protein sequence ID" value="ABF87419"/>
        <property type="gene ID" value="MXAN_4471"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4471"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_7"/>
    <dbReference type="OMA" id="TEVFWAA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="23638" checksum="F3D6E3929E7F7A90" modified="2006-07-11" version="1">MGIAERKERQRAELREQILRVARDIVVKEGFPALSMRKLADAVEYAPATLYLHFENREAIAKELCVRGFQDLLAMLEPAAQVEDPLERLPKLAEAYVRFGLEHPETYRLIFMEDPKLSTALFGDHPEGPGPRAFGVLVQVFVDLLATGRLEEGTKPEQLAEVLWAGVHGIVSLRLTCTGFPGTPAEELTQVLVTTLVKGLPGLKAGRAQKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D484</accession>
    <name>Q1D484_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cofac_haem_bdg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4366"/>
    <dbReference type="EnsemblBacteria" id="ABF88197">
        <property type="protein sequence ID" value="ABF88197"/>
        <property type="gene ID" value="MXAN_4366"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4366"/>
    <dbReference type="eggNOG" id="COG3016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035968_0_0_7"/>
    <dbReference type="OMA" id="CHLPAQV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007314">
        <property type="entry name" value="Cofac_haem-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04187">
        <property type="entry name" value="Cofac_haem_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cofac_haem_bdg" evidence="1">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="517" mass="57254" checksum="C2F3DB861D9643E6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D488</accession>
    <name>Q1D488_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554363.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88462">
        <property type="protein sequence ID" value="ABF88462"/>
        <property type="gene ID" value="MXAN_4362"/>
    </dbReference>
    <dbReference type="GeneID" id="41361674"/>
    <dbReference type="KEGG" id="mxa:MXAN_4362"/>
    <dbReference type="HOGENOM" id="CLU_182006_0_0_7"/>
    <dbReference type="OMA" id="KMPSVND"/>
    <dbReference type="OrthoDB" id="1997762at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030822">
        <property type="entry name" value="MXAN_4361/MXAN_4362"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04563">
        <property type="entry name" value="TIGR04563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9559" checksum="40CC17D1F630F311" modified="2006-07-11" version="1">MATTDHRKQSLYFPEDMLEEIQREATRQDRSLSWIVQQAWKVARGDIRKMPSVNDVLSPPPRPAAPAPAPAQPVTAVAVAPSEEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4C2</accession>
    <name>Q1D4C2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-specific glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4327"/>
    <dbReference type="EnsemblBacteria" id="ABF92654">
        <property type="protein sequence ID" value="ABF92654"/>
        <property type="gene ID" value="MXAN_4327"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4327"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_7"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="7">
        <location>
            <begin position="256"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="509" mass="56970" checksum="A188BDA185F0837B" modified="2006-07-11" version="1">MRAPAPTPKRTVYTEAMEIFHRAADLIALDKRVRLELEEPDYEHIFYVTAKLKDRLVPLSEEKARTFSNLPETQVRNKEGLELLANGNIILNGRALLGSDVDIRQGHLRLPDGKVYQLVPGESQRFKAYRVQHNQARGPYKGGLRYHREVSLDLFKALAAEMTWKTAIAEVPFGGGKGGIQIDPREYGREEIEAITLRFMYRLKSMIGPDIDIPAPDVGTNPGIMALLYRQYSDGERERHNLRGIVTGKDVRIGGSEGRHKATGQGVAFCIEDYYADRGESVKGKTFIIQGFGNVGSHAANILSQMGARLLAVNDADGTIFNGDGIDVTALSAYVQDPKNLKRSVLGFPGAQRIEKKDLWDVQADILVPAALGGEITADVAERLRVKLVAEGANGPTTPEADRILEKRGIELIPDIIANAGGVTVSYYEWIQNKRMERWSEAEVDQRLERAMKRNYRIIRDISRNQPRKTEMHDSRQYCIGETVDTRCAAMILALKRIEAHYLLEGFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4K4</accession>
    <name>Q1D4K4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554247.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4244"/>
    <dbReference type="EnsemblBacteria" id="ABF86793">
        <property type="protein sequence ID" value="ABF86793"/>
        <property type="gene ID" value="MXAN_4244"/>
    </dbReference>
    <dbReference type="GeneID" id="41361560"/>
    <dbReference type="KEGG" id="mxa:MXAN_4244"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="CAYLMKP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="155"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="368" mass="39483" checksum="2F30EF176E0F9E24" modified="2006-07-11" version="1">MSEPTSPSRPSVLVVDDNAAFLDNLEELLGDAGYAVRGASSCKAARERVREGFDVALVDLRLPDGDGTALAAELKAASPDSEVVLLTGFATLETAVAAVRAGACAYLMKPCAPQELLLTLEQAMRQVRLHAEKRELARRAQVTEKLAAVGTMTAGLSHEIRNPLNAAALQLSVLERRLRRLPDGQQAPLLEPLLLVRDEIRRLDHILEDFLQFARPREFRPASVDVNEMLRRVVDLLSGQAASRKVSLEVTPREAPVPSVAGEEERLRQVLINLCLNALEATPAGGTVTLSAGHEGGRVWLTVDDSGPGVPQEARDRIFEPFFTTKAQGSGLGLSIVHAIVTQHGGSLEVDTAPGGGARFILRMPLAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4L3</accession>
    <name>THIC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="1">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="1">HMP-P synthase</shortName>
            <shortName evidence="1">HMP-phosphate synthase</shortName>
            <shortName evidence="1">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiC</name>
        <name type="ordered locus">MXAN_4235</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554238.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D4L3"/>
    <dbReference type="SMR" id="Q1D4L3"/>
    <dbReference type="STRING" id="246197.MXAN_4235"/>
    <dbReference type="EnsemblBacteria" id="ABF86660">
        <property type="protein sequence ID" value="ABF86660"/>
        <property type="gene ID" value="MXAN_4235"/>
    </dbReference>
    <dbReference type="GeneID" id="41361552"/>
    <dbReference type="KEGG" id="mxa:MXAN_4235"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_7"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000004780" description="Phosphomethylpyrimidine synthase">
        <location>
            <begin position="1"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="386"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <sequence length="624" mass="68784" checksum="A67805AA5E05B42C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4M3</accession>
    <name>Q1D4M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="5" type="ORF">MXAN_4225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554228.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4225"/>
    <dbReference type="EnsemblBacteria" id="ABF87311">
        <property type="protein sequence ID" value="ABF87311"/>
        <property type="gene ID" value="MXAN_4225"/>
    </dbReference>
    <dbReference type="GeneID" id="41361542"/>
    <dbReference type="KEGG" id="mxa:MXAN_4225"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_2_1_7"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19670" checksum="DFFA0022FED5D9A5" modified="2006-07-11" version="1">MTTVIRETKETQVRVELAPGKGVTNVDTGLKFFDHMLATFARYAGLDLSLHARGDLTHHVMEDVAITLGTAVQQVIPATAARFAERTIPMDDALVQACLDAGGRFYYQGPLKNRLYEHWMRSFSEHARVTLHLRVLRGKDSHHATEASFKALGLALRDAMVDSGSVFSMKGSVSLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4R0</accession>
    <name>Q1D4R0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate/guanylate cyclase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554191.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4188"/>
    <dbReference type="EnsemblBacteria" id="ABF86692">
        <property type="protein sequence ID" value="ABF86692"/>
        <property type="gene ID" value="MXAN_4188"/>
    </dbReference>
    <dbReference type="GeneID" id="41361506"/>
    <dbReference type="KEGG" id="mxa:MXAN_4188"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739461_0_0_7"/>
    <dbReference type="OMA" id="MNKAEVP"/>
    <dbReference type="OrthoDB" id="676381at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="456" mass="48407" checksum="332D2EC19B55ADD4" modified="2006-07-11" version="1">MVRSCDCTIDGGAYTARALKTANLAIVFTDIKGFTERTSRQTLEENQRLLQVHEALLAPLFKAFGGRIVKSIGDAYLVTFESPTQAVLSGIAIQDRLWHHNRTVEVSEQIHVRVAINVGEVRLDGNDIFGEPVNIAARVEGIAEAGEVYFTEAVYLAMNKAEVPSKEVGAYELKGIPGKIRVFHVPRAPYRVEAPAPSAIAETPGSESMPPFGNLALSRVSEASSPGAQVDLSVLGQRAAAGAAVISQRAAAGATVLGQQAAELGRQARTVGGSLFSRGMATLPPQVQKHRALVGVGAAVVLAGVAMLAFSGDETVRAIKAVERAPEEERTALAKDVRTLIMKEEDSGRRNFLLGRLTEATGKPDDALKVYATAVKAGSRAAEDRLIEMLSHARCDVRSDAASTVGRLQLKRAVSALEDLKSDGGPDDGVRTGLFGISKCDSKVAAESALKGFKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4R8</accession>
    <name>Q1D4R8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91486">
        <property type="protein sequence ID" value="ABF91486"/>
        <property type="gene ID" value="MXAN_4180"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4180"/>
    <dbReference type="eggNOG" id="ENOG5032K9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625325_0_0_7"/>
    <dbReference type="OMA" id="WFPNRDS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="494" mass="53259" checksum="B5D320CCEAA46C5F" modified="2006-07-11" version="1">MSAGNRWRGQPSEATSGKRACRPSYRPQIVATTANFTVRDGPVAFLFPSLDSAMSEPATQAHPVPQHVHNAQMQVAAALEQATGKPVDLLKAPWVEIEPAIAQLTGGQFQVNKPEHQTLALGLAGAFALRLIQEHQAFWFPNRDSPEGATLGFPEAIIMLSPFGAVMDSLGQGKLARLEDLAADIRRSLGQARFGGSPAQALGGQAPKLTPVDYQRLFDPGFLQFVVLDPKKAATALETKPDGLARDVRNALGRTQPPLPPEARQQFEGQIVQSLQRLDTTKSLIDQAERAPRLAELMAHLFGTIGGTGSAPEDFWHDLVLPLLFIGTPASFPPLDEEELEMFRQGADPLPLFVDLVPHAHKAPDEGLLGAFEMSDIGLVHPGFGRVGALRLIRINASRIQPLLEQFDPAKTAETLQRFSEYVAKAAGKPATESPQGKEMLQAALTLLSDLKRSVTQVQGGELSLRRLTEAEAASEQALAVVRKALQGSIILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5B2</accession>
    <name>Q1D5B2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3981"/>
    <dbReference type="EnsemblBacteria" id="ABF92587">
        <property type="protein sequence ID" value="ABF92587"/>
        <property type="gene ID" value="MXAN_3981"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3981"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_2_0_7"/>
    <dbReference type="OMA" id="SEYVYGH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="PTHR33835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="28850" checksum="9FF3C0C98A0342FA" modified="2006-07-11" version="1">MMTADLEWNDGVRPYVPLSTLKPVADGVWWVDGPVARMRVGPVSLPFPTRMVIVRLGTGGLWLWSPTAPTPELFEQVDALGTVEHLVSPNRFHYAGIPAWKARYPRATAWASPGVRERARSQQMDVPFDADLDDAAPSAWSTELGQLIFRGSRFVEEVVFFHGESSTLILADLVMALEPERLRPRLRWLLTLGGTMWPGQTPREVRVTTWGRTAQARACYQQMMAWQPRRVLLAHGRCYLDEGVAPLERAFSWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5E2</accession>
    <name>Q1D5E2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3951"/>
    <dbReference type="EnsemblBacteria" id="ABF92358">
        <property type="protein sequence ID" value="ABF92358"/>
        <property type="gene ID" value="MXAN_3951"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3951"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_1_0_7"/>
    <dbReference type="OMA" id="TACVEVT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="37"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="31825" checksum="49F1F0AF1B1CC257" modified="2006-07-11" version="1">MRASQAEAPHSRRLTMEVRFHGVRGSIAVSGSRIGGNTACVEVTSQGHRLILDAGTGIRALGEIMMREGAPQEATLFFSHLHWDHVQGFPFFTPAWLPTSELTLYGPGANGAQALQSELAAQMQPPHFPVPLSTMRSRMDFRSALHARPVEVGPFRVTPIDVPHPQGCLAYRLEADGHSFVYATDVEVRVQELAPEVGRLFEGADVLCLDAQYTPDEYEGRKGVAKKGWGHSTMMDAAGVAGLVGARRLCLFHHDPAHGDDMLEDMAEQARALFPVCEPAREGQRLVLGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K8</accession>
    <name>Q1D5K8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCPU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3885"/>
    <dbReference type="EnsemblBacteria" id="ABF86408">
        <property type="protein sequence ID" value="ABF86408"/>
        <property type="gene ID" value="MXAN_3885"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3885"/>
    <dbReference type="eggNOG" id="COG5430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103262_4_1_7"/>
    <dbReference type="OMA" id="YQDQARA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007893">
        <property type="entry name" value="Spore_coat_U"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05229">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00972">
        <property type="entry name" value="SCPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188414" description="SCPU domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="SCPU" evidence="2">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="18436" checksum="325D31DB71BE95E1" modified="2006-07-11" version="1">MEHATQMNAIKTTVAAVTAAASLVAFSSAEAATATANLNVTANVGGSCAIGSGGGGGTLNFGTYDPIIVNSALGIDLFGTGTLSVQCTLLGTAVITLGQGLHPASGSTDAAPQRRMRNTASADYLAYGLNQDVTRLIGWGNTAGSGLPFLGTGLPVPVLVYGTVPRGQNVPSGTYNDTVVATITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6F5</accession>
    <name>Q1D6F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553604.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3578"/>
    <dbReference type="EnsemblBacteria" id="ABF92492">
        <property type="protein sequence ID" value="ABF92492"/>
        <property type="gene ID" value="MXAN_3578"/>
    </dbReference>
    <dbReference type="GeneID" id="41360924"/>
    <dbReference type="KEGG" id="mxa:MXAN_3578"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_14_1_7"/>
    <dbReference type="OMA" id="PADVTGY"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="33291" checksum="0E2374E33B6E82ED" modified="2006-07-11" version="1">MRDMKDSLKGRVALVAGGTRGAGRGIAVQLGAAGATVYVTGRTTRAQRSEQNRPETIEETAEQVTAAGGLGVAVQTDHLVPEQVQALVERIDGEQGRLDVLVNDIWGGESIFEWNKSVWEHSLDKGLRLLRLGVDTHLITSHFALPLLIRRPGGLVVEVTDGTADYNATNYRISTFYDLAKASVLRLAWSQARELRPHGATAVALTPGWMRSEGMLEHFGVTEANWRDATVKEPHFVISETPAYVGRAVAALASDADKARWNGQSLSSGQLARVYGFADLDGSQPDAWRYVVEVQDAGKPADATGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P2</accession>
    <name>Q1D6P2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553517.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3486"/>
    <dbReference type="EnsemblBacteria" id="ABF87203">
        <property type="protein sequence ID" value="ABF87203"/>
        <property type="gene ID" value="MXAN_3486"/>
    </dbReference>
    <dbReference type="GeneID" id="41360833"/>
    <dbReference type="KEGG" id="mxa:MXAN_3486"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_1_7"/>
    <dbReference type="OMA" id="FIHDEVE"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="4">
        <location>
            <begin position="39"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="270" mass="30207" checksum="ED3D1FD06733EF27" modified="2006-07-11" version="1">MAMRQSLHVMQSASNSSPHAPDRWFPTRKPLTDPRLRLFCLPYAGGSVAIYNQWSQGLPAGVELCPVQLPGRERRLSEKPIGSLPALVDALLPAIAPLLDRPFAFFGYSMGARISLELARRLQARNGPRPVGLFLGAAGPPSVNTREPIHHLPEPEFIAQLRRYDGTPEEIFQHRELLELVLPMLRADFGIAFTEDGPQPAKLEVPISVVGSPEDKHVPTANLERWRDETRSEDVRVRLFPGGHFFIKSQRDALLAHISEDLNRWMGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Q5</accession>
    <name>Q1D6Q5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553504.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3471"/>
    <dbReference type="EnsemblBacteria" id="ABF86930">
        <property type="protein sequence ID" value="ABF86930"/>
        <property type="gene ID" value="MXAN_3471"/>
    </dbReference>
    <dbReference type="GeneID" id="41360819"/>
    <dbReference type="KEGG" id="mxa:MXAN_3471"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461401_0_0_7"/>
    <dbReference type="OMA" id="WRQFLQE"/>
    <dbReference type="OrthoDB" id="398011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="591" mass="65188" checksum="6F7784089424A02A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S7</accession>
    <name>Q1D6S7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553482.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3449"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF87965.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1029" mass="109745" checksum="050477AD33095499" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D715</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
            <fullName evidence="4">Glycosyltransferase 1 family protein</fullName>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_3262"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="38206" checksum="6B8055893B11A73D" modified="2006-07-11" version="1">MRVLLVGDYPPPHGGVAVHVQQLHGYLRGCGVDVRVLDIGKGGRPAPDVIPARGAAPFALWLARHVATGWTIHVHTSGNNPKSWVLAGMVGSLPGPKSPRVITLHSGLLPDYLAASDTRRSFVRVALAGYARVVAVSDAVKSALVGCGVPAEKIDVLPAFCASQVRPGPVPSAAEAARSRRRVLLSMAHHPSPVYGRALMFRALRELAQTWPDVGLALFGPGLESEAFIRDVREARVAGHLEVLGELEHSAALGLIARSDAFVRPTTHDGDSISVREALTLGVPCVASDVCVRPQPARVFAAGNARELARVIREAVAAGLMHVPQVDAGPELLSLYGELSSSNGLKSSHEQGSGLGETRHAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7B5</accession>
    <name>Q1D7B5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3259"/>
    <dbReference type="EnsemblBacteria" id="ABF90910">
        <property type="protein sequence ID" value="ABF90910"/>
        <property type="gene ID" value="MXAN_3259"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3259"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_1_1_7"/>
    <dbReference type="OMA" id="ATAMWNG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="61"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="40944" checksum="D5A313BCB3466CA8" modified="2006-07-11" version="1">MSYHRVVSDFTGELQRSIPGLLISQETFRRHLEEAHAAGFELASIGDAVDVMNGRRVAKKDLCVVTFDDGYRDVYRYAYPVLKEMGVPAITYLPTAFISTDKRFNHDRLFHLLRRVQERRFRPFYDSLPAPALQLLGPILSGQKTVSASLDDFIGEHPTRVLTEIIDALEQQLGGGADLVPEQGDVMNWDEVRRMARDGFEFGAHTLGHTVLTLEPQEVVEREILESKRAIEREVGITVRDFAYCNGWYSDEVIRVLSANGFRSGVTTEDMPNRIGGDPFTLKRKVLWENFSLGMLGDYSSALTGCQLDDCFGVLGMSSPVPGKRPHFISAPTVGNQLSSAPVRVGPKPATSNEIVVGPESATTIQEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7K3</accession>
    <name>Q1D7K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91383">
        <property type="protein sequence ID" value="ABF91383"/>
        <property type="gene ID" value="MXAN_3167"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3167"/>
    <dbReference type="HOGENOM" id="CLU_1407459_0_0_7"/>
    <dbReference type="OMA" id="GAQMDGW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="24625" checksum="1140B83AA3E56F09" modified="2006-07-11" version="1">MTSAQRRARKVARKETRVMTEQEAYVKQMDAEKRRLDARIAETEAQADVRQASDELKDMSGIRRVFDTFRIKLDELSKRQTQNFEQGKAELRKSYDDTNQAVIEMDAKMALVRAGYERKREAELRALGAQVDGWEASVAQSRAEDSRLTRQELQFIRRSLQDTESALRRLMSSHGENWSKLKKDFEDSWRELRERSDKIRRGADVQPSSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7N6</accession>
    <name>Q1D7N6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553184.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3134"/>
    <dbReference type="EnsemblBacteria" id="ABF91115">
        <property type="protein sequence ID" value="ABF91115"/>
        <property type="gene ID" value="MXAN_3134"/>
    </dbReference>
    <dbReference type="GeneID" id="41360495"/>
    <dbReference type="KEGG" id="mxa:MXAN_3134"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116690_0_0_7"/>
    <dbReference type="OMA" id="QTCNLKE"/>
    <dbReference type="OrthoDB" id="1739746at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="15029" checksum="93E135064455AFF8" modified="2006-07-11" version="1">MRAMNEKSASYQSWLESFASEHGATAGTVHLQRGDDLFLVAALNIPPPLMAAVQHVPHGKGMAGLAQVRKQPVQTCNLKEDTSSDIKPGAKAVDARAAVAIPVLDATGRVRAVVGIAFTEEGSLAAERETSLMAAASRLPIADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7S0</accession>
    <name>Q1D7S0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">glyQ</name>
        <name evidence="10" type="ORF">MXAN_3100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553150.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3100"/>
    <dbReference type="EnsemblBacteria" id="ABF92675">
        <property type="protein sequence ID" value="ABF92675"/>
        <property type="gene ID" value="MXAN_3100"/>
    </dbReference>
    <dbReference type="GeneID" id="41360461"/>
    <dbReference type="KEGG" id="mxa:MXAN_3100"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_7"/>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="OrthoDB" id="676868at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="38099" checksum="59EC27749D80D4D6" modified="2006-07-11" version="1">MYFQDLIFTLQKHWADQGCINTQPYDVEVGAGTMAPYTFLRALGPEPWNVAYVQPSRRPADGRFGENPNRLFQHHQFQVILKPAPKNVQELYLESLRKIGIDPLEHDIRFVEDDWESPTLGAWGLGWEVWCDGMEVTQFTYFQQCGGFDCKPVSAELTYGLERICMYLQNVENVFDLEWVKGVKYREVFHPNEVEMSKYALQESDAQMLFALFDAYEKECKRLIERQLPLPAYDFALKCSHAFNLLDARGAISVTERANFIKRVRDNARLCAEGYLQMRERLGYPLLKSPWTVGEQPPVLEGKPASDYWKTVVLNKPVEKKQKAEVAHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8B4</accession>
    <name>Q1D8B4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent metalloprotease, FtsH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552959.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2898"/>
    <dbReference type="EnsemblBacteria" id="ABF90220">
        <property type="protein sequence ID" value="ABF90220"/>
        <property type="gene ID" value="MXAN_2898"/>
    </dbReference>
    <dbReference type="GeneID" id="41360266"/>
    <dbReference type="KEGG" id="mxa:MXAN_2898"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391201_0_0_7"/>
    <dbReference type="OMA" id="RWVGESE"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="288"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="706" mass="78072" checksum="EBB73F6EAC4C815C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8H5</accession>
    <name>Q1D8H5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552898.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86775">
        <property type="protein sequence ID" value="ABF86775"/>
        <property type="gene ID" value="MXAN_2837"/>
    </dbReference>
    <dbReference type="GeneID" id="41360208"/>
    <dbReference type="KEGG" id="mxa:MXAN_2837"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844191_0_0_7"/>
    <dbReference type="OMA" id="CGPSETE"/>
    <dbReference type="OrthoDB" id="1061192at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="36942" checksum="C3E63DA8A10CFFD7" modified="2006-07-11" version="1">MRRYVGSAFLAAGLLVGCGPSETETSTQQPQEQQQGLLTEADVDVATECQGILQFVNEATFNTLDAYLPSNVVHNLVNRRAVSQFVSLADISSVALVGPARLQQIEQGARSQDYIDADCYGIADGLALSQDDAVAIVSLVNSISSTELHDILPYAWNGALNLRNQRPFTNADAIANTTGIADVSFRNLRNAATLSRPFEALINAVNNVPRPHGGVFMARHFDWWENMNGRFYNFQITECFGERTERVSEPHNHRGTNADAAEVRAHVEAFVNAAARFGTLDPEVKAAGLANLNTLIEGRSFFGCSYGYARDPWSGHGATFFVDTESGFSVYTDSYWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8H7</accession>
    <name>Q1D8H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2835"/>
    <dbReference type="EnsemblBacteria" id="ABF90133">
        <property type="protein sequence ID" value="ABF90133"/>
        <property type="gene ID" value="MXAN_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2835"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_0_7"/>
    <dbReference type="OMA" id="QRRWYRL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="123" mass="14467" checksum="A9BF6FACE741676B" modified="2006-07-11" version="1">MCICMFMQLDVFQVLADPTRRRIVETLRYGEQQVSDVVEKAGIHQSGVSRHLRILSESGFVSMRPDGQRRLYALKPEPFQELDGWLTGYRQLWEARLDRFGAALEKKQQQQQTRRVEEKGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8X9</accession>
    <name>Q1D8X9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552745.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2677"/>
    <dbReference type="EnsemblBacteria" id="ABF89500">
        <property type="protein sequence ID" value="ABF89500"/>
        <property type="gene ID" value="MXAN_2677"/>
    </dbReference>
    <dbReference type="GeneID" id="41360055"/>
    <dbReference type="KEGG" id="mxa:MXAN_2677"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946031_0_0_7"/>
    <dbReference type="OMA" id="GLAHPCE"/>
    <dbReference type="OrthoDB" id="1529793at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M10" evidence="1">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="32022" checksum="AC215998867E3F73" modified="2006-07-11" version="1">MMPLAPLMLALTLGQVDPYVRSRVDAGDTRTQCLYWTSNRVVWNQSTYGNPDTAGDSEFDAIRASFQSWQDIFAECGNLTLVEGPRVDEREVGYRRQGTNTNLVLFRTRDCNSVVPATDACWADDTCANTHDCWDDDDNTIAITLTTYDERSGIIYDSDISFNAARFSFTTANGGTCFPPVTTHCVATDVQNTATHEVGHLIGLDHTRATGSTMNPSAPPGEVSKRVVDSGSRGFVCDAYPQGQASQSCLHPVTSIELGPKAGGCSAAGPGGALSLVAVWSLWLARRRRREEAVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y1</accession>
    <name>SYE_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">MXAN_2675</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552743.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8Y1"/>
    <dbReference type="SMR" id="Q1D8Y1"/>
    <dbReference type="STRING" id="246197.MXAN_2675"/>
    <dbReference type="PRIDE" id="Q1D8Y1"/>
    <dbReference type="EnsemblBacteria" id="ABF89409">
        <property type="protein sequence ID" value="ABF89409"/>
        <property type="gene ID" value="MXAN_2675"/>
    </dbReference>
    <dbReference type="GeneID" id="41360053"/>
    <dbReference type="KEGG" id="mxa:MXAN_2675"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_7"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000330984" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="479" mass="53209" checksum="A4EB8C0F73405E51" modified="2006-07-11" version="1">MPPALRVRFAPSPTGYLHIGGARTALMNFLQARRQGGTFVLRMEDTDQGRSTPESVQAILDGLNWLGIDWDEGPGKEGPYAPYFQMQRLDTYRKHADQLIAEGKAYRCYCTKEDLDAQRQVAEKAGGAFKYPGTCRERTEPPAGRNAADAVIRFKMPAGDGSVSFTDKALGTITKTHSDLDDWVMMRADGIPVYNFGCVIDDHLMDITLVARGQEHVNSTFPQLMLYQALGWTPPDFAHLPLILGPDREKLSKRKHPEADVMVHKRNGVMPEALLNFVIRLGWSHGNDEVISREQMLEWFDFSDVGTTSGVWNPEKLLWLNQQWMKQLPVETVVERLLPFLEAKGIQAKGDPRLETLVRTLRERSNTLEDIATTAANVYFRSGITLDEKAATKHLSGESLNLLRKVRETLTALPEWSVEALDGVVKQVSEASSVGMGKVAQPIRVALTGNTTSPGIGETLVLVGRDESLLRIDAALTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D986</accession>
    <name>Q1D986_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552638.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2568"/>
    <dbReference type="EnsemblBacteria" id="ABF89891">
        <property type="protein sequence ID" value="ABF89891"/>
        <property type="gene ID" value="MXAN_2568"/>
    </dbReference>
    <dbReference type="GeneID" id="41359946"/>
    <dbReference type="KEGG" id="mxa:MXAN_2568"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_7"/>
    <dbReference type="OMA" id="NRDPRGH"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="15809" checksum="1D48974554BAA689" modified="2006-07-11" version="1">MPEYRNPKPTVDCIIELPGERIVLIRRANPPVGWALPGGFVDEGEPLDVAAVREVQEETGLHVKLSEQFFTYSDPRRDPRQHNISTVYIGSAEGEPQGADDAAEARAFRVDDLPKDLCFDHDTILSDYVTYKRTGQRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B9</accession>
    <name>Q1D9B9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">purE</name>
        <name evidence="6" type="ORF">MXAN_2535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552605.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2535"/>
    <dbReference type="EnsemblBacteria" id="ABF90143">
        <property type="protein sequence ID" value="ABF90143"/>
        <property type="gene ID" value="MXAN_2535"/>
    </dbReference>
    <dbReference type="GeneID" id="41359913"/>
    <dbReference type="KEGG" id="mxa:MXAN_2535"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_7"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="5">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17393" checksum="215B8A6FD93412AA" modified="2006-07-11" version="1">MASTVTPWVGVIMGGRSDLEHLQPAVDILKELGIPHEVRVVSAHRTPDWMMEYASTAESRGLSVIIAAAGGAAHLPGMVSSKTLLPVIGVPMPTTLLSGLDALLSIVQMPKGVPVGTQAIGKPGAANAALHAAAILCLKYPELRERLAAWRKARTDEVLAHRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E1</accession>
    <name>Q1D9E1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
            <shortName evidence="3">T2SS protein E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gspE</name>
        <name evidence="5" type="ORF">MXAN_2513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552584.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2513"/>
    <dbReference type="EnsemblBacteria" id="ABF92256">
        <property type="protein sequence ID" value="ABF92256"/>
        <property type="gene ID" value="MXAN_2513"/>
    </dbReference>
    <dbReference type="GeneID" id="41359890"/>
    <dbReference type="KEGG" id="mxa:MXAN_2513"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_3_7"/>
    <dbReference type="OMA" id="RSRIDGM"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="4">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="605" mass="65970" checksum="FFA04BFB6038CEE7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H4</accession>
    <name>Q1D9H4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rho</name>
        <name evidence="10" type="ORF">MXAN_2479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2479"/>
    <dbReference type="EnsemblBacteria" id="ABF86593">
        <property type="protein sequence ID" value="ABF86593"/>
        <property type="gene ID" value="MXAN_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2479"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_0_7"/>
    <dbReference type="OMA" id="PRLPHFA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="9">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="319"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="566" mass="61835" checksum="E7B159160C119F74" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9N1</accession>
    <name>Q1D9N1_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_2422"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1225" mass="132884" checksum="EB8F85D1684B393F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Q2</accession>
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    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
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    <dbReference type="EnsemblBacteria" id="ABF88015">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="28896" checksum="16A330CBEC003123" modified="2006-07-11" version="1">MTSISPPESLRCINADSREPAGYRAALGDTRAALLHTDPPYCLLTRRRKGGDLRDTRAHKKIDQNPIVRFETVRDYRAFSEAWLSSATAHLTPDAPLIIWTNLLGKEPILTAARGLGYPHLRGEYVWGKRTTDKNANEQTLRVYEVALVIARTPAPPLAPGDLPTVWAVVGGYDDEGEAKRWGGHPHHKPFSVLEPLVRTYSRPGDTVLDPFAGSGSMPSAALRLGRRPACLEIEPEWAERVTHRLRETAREEAQRASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA66</accession>
    <name>Q1DA66_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF92305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2236"/>
    <dbReference type="EnsemblBacteria" id="ABF92305">
        <property type="protein sequence ID" value="ABF92305"/>
        <property type="gene ID" value="MXAN_2236"/>
    </dbReference>
    <dbReference type="GeneID" id="41359624"/>
    <dbReference type="KEGG" id="mxa:MXAN_2236"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_1_7"/>
    <dbReference type="OMA" id="WLATINS"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="4">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="5">
        <location>
            <begin position="416"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="617" mass="65050" checksum="8252328AC723D325" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG3</accession>
    <name>Q1DAG3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552215.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2137"/>
    <dbReference type="EnsemblBacteria" id="ABF89294">
        <property type="protein sequence ID" value="ABF89294"/>
        <property type="gene ID" value="MXAN_2137"/>
    </dbReference>
    <dbReference type="GeneID" id="41359537"/>
    <dbReference type="KEGG" id="mxa:MXAN_2137"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_7"/>
    <dbReference type="OMA" id="AWYFARA"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="372" mass="40844" checksum="A8716958E6961D44" modified="2006-07-11" version="1">MSTRIIDSLAKYHLLGQTGLRVSPLALGTMNFGTDWGWGITSEDAHRLLTRYLEAGGNFIDTADAYTSGSSERIIGDYFAKHGGRERAVIATKFSANLSPGDPNAGGNSRKHIYAALEGSLRRLKMSYVDVYWLHVWDGLTPVEEVMGTLTGLVREGKVRYIGFSDVPAWYFARAQTLAERNHWEKVAALQLEYSLAERNVEREHLPAALAMGAALTPWSPLAGGLLTGRYTRDGNQPKGDGRAHALLASGNPVADKFLQERPWAIVEELVAVAKEVERSPAQVALNWVATRPAVVSTIIGASRLEQLEDNLHALDFKLPHELSARLDAASRPELFNPYVFFENPFFTKGMLAGNTTVSAEPSGFRGPLQPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAM9</accession>
    <name>RIMP_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">MXAN_2065</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552149.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAM9"/>
    <dbReference type="SMR" id="Q1DAM9"/>
    <dbReference type="STRING" id="246197.MXAN_2065"/>
    <dbReference type="EnsemblBacteria" id="ABF90125">
        <property type="protein sequence ID" value="ABF90125"/>
        <property type="gene ID" value="MXAN_2065"/>
    </dbReference>
    <dbReference type="GeneID" id="41359474"/>
    <dbReference type="KEGG" id="mxa:MXAN_2065"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_2_7"/>
    <dbReference type="OMA" id="YIHVSLY"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000384715" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="161" mass="17929" checksum="323B03D22DD3300B" modified="2006-07-11" version="1">MSEKNLKQTVEERALALLEPIVAGEGLELVDLEFLREREGWVLRLFIDKPGGRVGLDECTQVSRAVDPSLDVEDFIPHEYNLEVSSPGVDRPLRKPTHFERVKGQQVKVKTFGPVGEPPRKNFTGTLTEVAGDGISVEVEGAGTFHILFKDIAKANLEFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR7</accession>
    <name>Q1DAR7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="4 9">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4 9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552111.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2027"/>
    <dbReference type="EnsemblBacteria" id="ABF86502">
        <property type="protein sequence ID" value="ABF86502"/>
        <property type="gene ID" value="MXAN_2027"/>
    </dbReference>
    <dbReference type="GeneID" id="41359437"/>
    <dbReference type="KEGG" id="mxa:MXAN_2027"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_1_0_7"/>
    <dbReference type="OMA" id="WQTPFLE"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27575" checksum="FD55569020B6FDA4" modified="2006-07-11" version="1">MNLLLLLDEDFLPDGTARLTGRRAQHAREVLRAEPGESLRVGHLGGLTGTGEVLENSAGVLHLRVTLTEPPPPRAGIDLLLAIPRPKALKKVLPAVASLGVDRIVLLNAARVEKSYFDSKVLDPAFVHELLIQGLEQARDTRLPEVLVRERFRPFVEDELDAFFGPQTLRLLPHPPARQSLRALGVGLAQRVVLAIGPDGGWVPFEADLLEAHGFHPFSLGPRILRVETAVPALLGQVALLREDIAAPPATTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB99</accession>
    <name>Q1DB99_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1828"/>
    <dbReference type="EnsemblBacteria" id="ABF91813">
        <property type="protein sequence ID" value="ABF91813"/>
        <property type="gene ID" value="MXAN_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1828"/>
    <dbReference type="eggNOG" id="COG1614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093395_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27361" checksum="C775611EEA2ECD58" modified="2006-07-11" version="1">MASEPLSMGDVCPATVFSSPSPHSTQHHENNMKTRSELDAMTVKQLRRYVIDRGLSFPYLGESKKAEIINKLIQFRAAREDETSAPPKAELPGPKHHALATPTPAPTHPLSNPAARGVHIPLSNPAAPGVHIPLSNPAAPGVHIPLSNPAAPGVHIPHTTGDVDDLFSLYRRIVHDTAMSVDARAGYLTAVVRVDKRISRRLDSQPNETLVALFRERLAAEDSQRVTVHPLAAQSFEEAAKEMSGADLGASSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB3</accession>
    <name>Q1DBB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551919.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1814"/>
    <dbReference type="EnsemblBacteria" id="ABF86375">
        <property type="protein sequence ID" value="ABF86375"/>
        <property type="gene ID" value="MXAN_1814"/>
    </dbReference>
    <dbReference type="GeneID" id="41359231"/>
    <dbReference type="KEGG" id="mxa:MXAN_1814"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063022_0_0_7"/>
    <dbReference type="OMA" id="VAGHCEG"/>
    <dbReference type="OrthoDB" id="1819521at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="38280" checksum="AA7B8F71E0261B54" modified="2006-07-11" version="1">MSGEAVLVASGARAPVGTTAESVAAAVRAGISRVRLLQVPELGRQADSFIARDGLLDAQEWCGVTRMAALGAAALDEVLAKLTPALPPRSLDVPVLVGLPEERPGWRASDASRVASALSALGSARLNLQVEPRLTGHASALEALRDAVTRVGHTSRCPLVIVGGIDSYHDVQTLAWLRERNQWLEEGTRMGFAPGEAAAFVAVMATPDTRRWRLAPHATVRAATTAHETKLIHSDDLNLGEGMTAAVAEALAPLEGTREVVEDVHSDLNGERYRAEEWGFVALRLGAAFRDAAAVHTPVSSCGEVGAATGALNLVICAQAWQRRYASGPRALLWGSSEAGLRAAALLEEPLSGSEEGAKPWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB5</accession>
    <name>Q1DBB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1812"/>
    <dbReference type="EnsemblBacteria" id="ABF90891">
        <property type="protein sequence ID" value="ABF90891"/>
        <property type="gene ID" value="MXAN_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1812"/>
    <dbReference type="eggNOG" id="ENOG5030UHF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097955_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="27588" checksum="7FE6365C037A2621" modified="2006-07-11" version="1">MKPFVEFVEKYRPGFSEKITPADWVDISMLEEDAGPLPGAYRRFLETMGASMGDLEIADAHFSIHSTLGVYRTMSWLQDSRYIFLAGDNGLASWHWFLDRSSPHGTDDCLVVNRLLDENYPPEGSHPMYVGLEEFLYYEAFKELRLPQLPFRRKFSSPDDAAAAARYRADAVTALAEEKGFKRLPPVEHCALYERGDAALLLYRHPTQPTFSFILGCEDSAEMERLAQDFETRTGLKSVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG2</accession>
    <name>Q1DBG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1762"/>
    <dbReference type="EnsemblBacteria" id="ABF91745">
        <property type="protein sequence ID" value="ABF91745"/>
        <property type="gene ID" value="MXAN_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1762"/>
    <dbReference type="HOGENOM" id="CLU_828544_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="33914" checksum="A13858B5D3D5263A" modified="2006-07-11" version="1">MADAHATATVVLQLRASCHREGPEESAAGAVGGRCDGWQVSRALPARMSIAAAHHPSAPSIGAASSRTARGASAQPTSFVRSAIPRAASASVAELEVHAAHRAADAAAVLGSNGVCVDVGIGYWSPANSNVRNACTNAPANADYTSPTAAQATCPWTCKPGYLRDGAGTKCVKNDAVQVLTCGGGEVAVGIHGQEGAGLDALGMRCARFNSGEIIGTAMGAPSIGGTGGNPFTQDCAEGEVVQKVAGINGWAEDSANEDWCSKNTLSTIQLSCRNLKTGRITVMPTVGGKNAGCKVGNLPEYSFGCGATGFLRGLVVDSANTSLYVGYVLDESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ2</accession>
    <name>Q1DBJ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin family protein, selenocysteine-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1731"/>
    <dbReference type="KEGG" id="mxa:MXAN_1731"/>
    <dbReference type="eggNOG" id="COG0526">
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</entry>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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                <person name="Madupu R."/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551655.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1544"/>
    <dbReference type="EnsemblBacteria" id="ABF86103">
        <property type="protein sequence ID" value="ABF86103"/>
        <property type="gene ID" value="MXAN_1544"/>
    </dbReference>
    <dbReference type="GeneID" id="41358988"/>
    <dbReference type="KEGG" id="mxa:MXAN_1544"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OMA" id="DEGWCAF"/>
    <dbReference type="OrthoDB" id="1412466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188123" evidence="1">
        <location>
            <begin position="30"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="25042" checksum="EA002EFF9F3A1349" modified="2006-07-11" version="1">MSPERPILLRTLASTLRLLVLSCLLVACASAPPTPDPPRGIAELEYAELCEATEAAPCVSLACDEGWCAFFLCEDVAPRVEPALMPVARPPLRRGWGVRLGIRNGAQPVITFPWRPHVQVRPVYQLPAGRYVRHHIFPQAPDLALYFQRAGIKIHDFTLVIPEHVHRYIHGGGPRGGRWNDAWAQFIKAHPHPPRPDVIYRHAGDLIFRFELTGKVMPYYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCH7</accession>
    <name>Q1DCH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551506.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1389"/>
    <dbReference type="EnsemblBacteria" id="ABF86188">
        <property type="protein sequence ID" value="ABF86188"/>
        <property type="gene ID" value="MXAN_1389"/>
    </dbReference>
    <dbReference type="GeneID" id="41358836"/>
    <dbReference type="KEGG" id="mxa:MXAN_1389"/>
    <dbReference type="eggNOG" id="COG3540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015982_2_0_7"/>
    <dbReference type="OMA" id="EFSDDCW"/>
    <dbReference type="OrthoDB" id="165142at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="67"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="172"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="741" mass="81402" checksum="06971B904F86E112" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL8</accession>
    <name>Q1DCL8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1348"/>
    <dbReference type="EnsemblBacteria" id="ABF88546">
        <property type="protein sequence ID" value="ABF88546"/>
        <property type="gene ID" value="MXAN_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1348"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_7_0_7"/>
    <dbReference type="OMA" id="QDEQVEC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="69"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="29095" checksum="77D823D4CDBBFFF9" modified="2006-07-11" version="1">MCPSGAGHDVGNPLPSVCTCLSRARPDSCYFLPRMGGHDARGRMPLSLVAQEPDLLFYTRQAAEHGGPVLVLGAANGRVVWALAGDGYDAVGVDPSGVMIRSAEERRNSEPEDVSRRARFLVADLRSLRLDERFPLVLAPQHALGLMPGKDDLEALLATVRHHLTPDGSFVYDVLNTPREPVIPRDDEAPSAGLEPRRPLFTLHLRERRAPGGPSPIRRLKLRHFTPEELDAALTAAGLVPRERYGRFDGKPFDLEDSRHIGIAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCV0</accession>
    <name>Q1DCV0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-(MS[2]IO[6]A)-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaE</name>
        <name evidence="1" type="ORF">MXAN_1266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551383.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1266"/>
    <dbReference type="EnsemblBacteria" id="ABF92447">
        <property type="protein sequence ID" value="ABF92447"/>
        <property type="gene ID" value="MXAN_1266"/>
    </dbReference>
    <dbReference type="GeneID" id="41358712"/>
    <dbReference type="KEGG" id="mxa:MXAN_1266"/>
    <dbReference type="eggNOG" id="COG4445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056571_1_0_7"/>
    <dbReference type="OMA" id="CEFKAAS"/>
    <dbReference type="OrthoDB" id="1900811at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045301">
        <property type="term" value="F:tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07910">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010386">
        <property type="entry name" value="tRNA-Hydrxlase_MiaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42637">
        <property type="entry name" value="PTHR42637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06175">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020736">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="207" mass="22740" checksum="BB2E79567EB0F632" modified="2006-07-11" version="1">MSRPTPSRRPLSGEGPVILHAATDPRWLPLALERFDEVLVDHAHCEKKAAANALSMLQAYPDLPGLPSQMARLAREESAHLARVLDLMAARGLTLTKDAGDPYAQGLQKLIRTPAAERRMDRLLVAAVIEARSCERLSLLAEGLTDPALARFYGELAQSEDGHQSLFYRLAVTASEGDETSVKARLEWMLEREAQVITDVGLRAAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCX0</accession>
    <name>Q1DCX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Developmental regulator SasN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sasN</name>
        <name evidence="3" type="ORF">MXAN_1244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1244"/>
    <dbReference type="EnsemblBacteria" id="ABF88232">
        <property type="protein sequence ID" value="ABF88232"/>
        <property type="gene ID" value="MXAN_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1244"/>
    <dbReference type="HOGENOM" id="CLU_793912_0_0_7"/>
    <dbReference type="OMA" id="RAHITEV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="39572" checksum="0D3EDC25648E25D9" modified="2006-07-11" version="1">MGRQAGTHLALGLSLMNLRSLALLLSLLLAMPGQAASGLEAVRGRAQSARAETRSLRGQQQALRDELNGLAARIETLKAQRQGRLMAGTELEDALRRSQELSGQLTGLAQAVVAAEGEAERAHLALHTALSDELTRLLAAWEGTADRGQREKLLEAVRSVRAEREAIRAALPASQVPSLDKATAGGDDPEDLLAQADTLRDTRDKVRERLKALRGRITEVREERDLDRRMNDFLGEESMFDDQDRRLRLRMGSDRTLQVERSVPGPSAPTFQGDSPDDPTPNVGGRPGEGVDPSRPPYPTQLSSRATDRRPQVETQRAQDLASGGPVDLAAMEAEATRLETLARELEGRATKLERRAQEMGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCY7</accession>
    <name>Q1DCY7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1227"/>
    <dbReference type="EnsemblBacteria" id="ABF91694">
        <property type="protein sequence ID" value="ABF91694"/>
        <property type="gene ID" value="MXAN_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1227"/>
    <dbReference type="HOGENOM" id="CLU_166796_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="95" mass="10326" checksum="C883132A7BB9FBDA" modified="2006-07-11" version="1">MTAEETQSVQLVVGSLLGTAGIGVLTWAAKSLVGEIRALVEKVARQDERINALAVELGALRRWRDEFAVGLPVQVRQTVELELLRRTQAASGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD39</accession>
    <name>Q1DD39_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551294.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1174"/>
    <dbReference type="EnsemblBacteria" id="ABF88277">
        <property type="protein sequence ID" value="ABF88277"/>
        <property type="gene ID" value="MXAN_1174"/>
    </dbReference>
    <dbReference type="GeneID" id="41358624"/>
    <dbReference type="KEGG" id="mxa:MXAN_1174"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_0_2_7"/>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="15221" checksum="A5E77A356B80107A" modified="2006-07-11" version="1">MFHAKELTVSSRGRGFTDITADVQRAVAESGARQGLCTVFLHHTSASLLLCENADPDVRRDLESFFSRLVKDGDPLFVHDAEGPDDMPAHVRTVLTQNALNIPVKDGRADLGTWQGVYVWEHRTSPHRRRVTVSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD98</accession>
    <name>Q1DD98_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_1115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551235.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1115"/>
    <dbReference type="EnsemblBacteria" id="ABF92710">
        <property type="protein sequence ID" value="ABF92710"/>
        <property type="gene ID" value="MXAN_1115"/>
    </dbReference>
    <dbReference type="GeneID" id="41358567"/>
    <dbReference type="KEGG" id="mxa:MXAN_1115"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_1_7"/>
    <dbReference type="OMA" id="ITWVFGG"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF92710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42427" checksum="BDE5EA9432F70382" modified="2006-07-11" version="1">MRAARGSFQIGSFRGIPVRVHFSLLLVLPLLAFLFGGAFQRAAEVAEVPPERLSGSPALWGLVVALGLFASVFIHELAHTVYALRRGGRVRSITLMMVGGVSELTEAPPRPRDEALMAAVGPLTSILLAVLLGGATWLLQEVRSFNLQFAFFYMASLNLFLGVFNLLPAFPMDGGRIVRASLAGRLGMVRATQVASWLGRGFAVLFGVWAVLSLNPFLVVIAFFIFMGAQGEAQQVRMKMTLERVPVADLMTPRRVGVDAGASLEQALWDLRRARLLLLPVTEDERPVGQVSLETVRAVPDSERMTRTVREVMVPAVVVRLDEDGWTALRRMAEEERPQLVVVEADGVLAGTLDVNDVQRGMALYQAREERSGQQDRRWRQERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDF1</accession>
    <name>Q1DDF1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase sigma-54 factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpoN</name>
        <name evidence="13" type="ORF">MXAN_1061</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551182.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1061"/>
    <dbReference type="EnsemblBacteria" id="ABF87365">
        <property type="protein sequence ID" value="ABF87365"/>
        <property type="gene ID" value="MXAN_1061"/>
    </dbReference>
    <dbReference type="GeneID" id="41358514"/>
    <dbReference type="KEGG" id="mxa:MXAN_1061"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_1_1_7"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="12">
        <location>
            <begin position="135"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="11">
        <location>
            <begin position="345"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF87365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="505" mass="56974" checksum="5AFB0D6F37C5682B" modified="2006-07-11" version="1">MAMELKQSLKLAQQLVMTPQLQQAIKLLQLSRMELLEQVREEMEQNPLLEQPDEQAPGDVGDKEPGEASLEADNMEVPRDVDLPAATSDTATEFKADGEGPPEIDWEQYLNSYQFNEPTTASNKGNVATDDMPSFEANLVKKADLVDHIQEQLGTLRLNDAERRIAMLILGNLDDDGYLKLPEVDGDPLIRLANEADVPMHVAERTLRRIQMLDPRGCGARDLQECLLIQLQGIREPHAPLLGLIIKRHMKYLESKNLPAIAKDLKVTLEEVVGAVRLLPKLDPKPGRNFSGDDAQYISPDVFVYKMGDDYTVVLNDDGLSKLRISGTYRNALKTGAVGPGQTKDFIQDKLRSAMWLIRSIHQRQRTIYKVTESIVKFQRDFLDKGIAYLKPLILRDVAEDIGMHESTVSRVTTSKYVHTPQGIFELKYFFNSSIARVSGEDTASEAVKHHIKQLVAQEDARNPYSDQKIVELLRSQGTEIARRTVAKYREVLGILPSSKRKRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS0</accession>
    <name>Q1DDS0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551063.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0942"/>
    <dbReference type="EnsemblBacteria" id="ABF86802">
        <property type="protein sequence ID" value="ABF86802"/>
        <property type="gene ID" value="MXAN_0942"/>
    </dbReference>
    <dbReference type="GeneID" id="41358401"/>
    <dbReference type="KEGG" id="mxa:MXAN_0942"/>
    <dbReference type="HOGENOM" id="CLU_2586028_0_0_7"/>
    <dbReference type="OMA" id="LRGCVYP"/>
    <dbReference type="OrthoDB" id="1873038at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="77" mass="8140" checksum="CEC8BFA937B0B105" modified="2006-07-11" version="1">MMDVKDAAVQTALRRACEEVGLPDSLRGCVYPLLRDPEGDWPGCCGGGCHPCASSLVDVAMRTLELLGTPRRAPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDV7</accession>
    <name>Q1DDV7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADYC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551026.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0905"/>
    <dbReference type="EnsemblBacteria" id="ABF87795">
        <property type="protein sequence ID" value="ABF87795"/>
        <property type="gene ID" value="MXAN_0905"/>
    </dbReference>
    <dbReference type="GeneID" id="41358364"/>
    <dbReference type="KEGG" id="mxa:MXAN_0905"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550753_0_0_7"/>
    <dbReference type="OMA" id="AKCYRWG"/>
    <dbReference type="OrthoDB" id="988833at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045426">
        <property type="entry name" value="ADYC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20032">
        <property type="entry name" value="ADYC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADYC" evidence="2">
        <location>
            <begin position="266"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="51193" checksum="99B69D3682A9EF97" modified="2006-07-11" version="1">MTEVSHVTLRLRMLPPCLAIYLLSACAPPVDETDTALTQQSFAGDEDDPDSHSQGTQLHATPVRTVMYDEALVQHDGALRVANLKLTRGEIVANMPLSVDGTTPSLMFCGGGAPANEKRSCGFVVDGQGVCSPGSLVTLMGGDSGSPRNRCTGAPVVRVCAGEAPCEHQGPGYLASANSSFSLNNCPAVTFTCPSSGVYTALAGPGTPNTTWLMQLTSRSSTYPTTRKILRGEELIGARLRQPSMGPALVVEDVINANALPNTEGSGMWEPSGHTFLYQVRYTTASVPLCPTGANWAVPVKGLFDLQGDRYESPRAFTLGCDAGVIAKCYRWGYHPWLDGATSGPITEAHWSCTRMARADYCGQGTSFTLDGTRIRPWDALTPAIISAPSPDSSSNDLTFEAGWNTAGPACLSHLRWKHLTAPCVPLNPPIYDANGNIVNDCRDPNTPYAPGKCAEICDNAEEAAQYYGSRVFNHSAINTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW8</accession>
    <name>Q1DDW8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative farnesyltranstransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551015.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0894"/>
    <dbReference type="EnsemblBacteria" id="ABF88066">
        <property type="protein sequence ID" value="ABF88066"/>
        <property type="gene ID" value="MXAN_0894"/>
    </dbReference>
    <dbReference type="GeneID" id="41358353"/>
    <dbReference type="KEGG" id="mxa:MXAN_0894"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_7"/>
    <dbReference type="OMA" id="LELFQNW"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="38711" checksum="C7F3B84FFD227478" modified="2006-07-11" version="1">MALTLPDAQPPTGLLPLEQAWLQLVQTEVETSLAELFELPDEAGLDVRWTQALTQARAYTLRPAKRLRPALVMAGHCLARGSAVVPSGLWRFAAGLELLHTFLLIHDDVADQAELRRGAAPLHRMLAPGRAGEDLAVVVGDHLFARALEVMLGSGLTCVAGVVQYYLGVCRHTAAGQYLDLDLGRAPLAEVTLFQTLRVAHLKTARYGFCAPLVCGAMLGGASSGLVEELERVGRHVGLAYQLRDDLLGLFGDSNVAGKAADGDFLQGKRTFPVLAAFARATEAERTELEALWALPVEQKDAAALARARALVESCGGRAACERMVVRASRAARRSLQSLPNPNGVRELLDALIARLAHRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE15</accession>
    <name>Q1DE15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0846"/>
    <dbReference type="EnsemblBacteria" id="ABF88735">
        <property type="protein sequence ID" value="ABF88735"/>
        <property type="gene ID" value="MXAN_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0846"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2220327_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="106" mass="11464" checksum="BE73A989164F1B77" modified="2006-07-11" version="1">MGRTLAAFEGRAEHPSSRRAPPLCLPGGAAQVPPAPPAARYQMARELAADLRRWLGEGDAYGQEEAAAELHDMAKRAHEVMLELCMRRPRGLQASEEAVSTNEPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE17</accession>
    <name>Q1DE17_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550966.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93158">
        <property type="protein sequence ID" value="ABF93158"/>
        <property type="gene ID" value="MXAN_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="41358304"/>
    <dbReference type="KEGG" id="mxa:MXAN_0844"/>
    <dbReference type="eggNOG" id="ENOG502ZGWY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342510_0_0_7"/>
    <dbReference type="OMA" id="LTRWRVW"/>
    <dbReference type="OrthoDB" id="1015543at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="814" mass="91324" checksum="8BDCDD7081636B9A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB5</accession>
    <name>Q1DEB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0742"/>
    <dbReference type="EnsemblBacteria" id="ABF91431">
        <property type="protein sequence ID" value="ABF91431"/>
        <property type="gene ID" value="MXAN_0742"/>
    </dbReference>
    <dbReference type="GeneID" id="41358213"/>
    <dbReference type="KEGG" id="mxa:MXAN_0742"/>
    <dbReference type="HOGENOM" id="CLU_1466720_0_0_7"/>
    <dbReference type="OMA" id="MDPDMQG"/>
    <dbReference type="OrthoDB" id="1299932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="20863" checksum="DFB7BA0541F7E64E" modified="2006-07-11" version="1">MAKDKDDNGGGFSGKRNKSWREIDAGRGKGSKYASRQDDPAQQKLERSASYQKYKAAADALFTGGELPEGLAKTFDPEGKRKAQKQAMQKVTESETRADWVKAVVDYLEKYPELPEDAYFLDSLLDHPRERIVDKALAKLEVLGDEGKLKTKVPQSLDQRLKSVELTSMDPDMQGRAKALREKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DED7</accession>
    <name>Q1DED7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550846.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0718"/>
    <dbReference type="EnsemblBacteria" id="ABF87541">
        <property type="protein sequence ID" value="ABF87541"/>
        <property type="gene ID" value="MXAN_0718"/>
    </dbReference>
    <dbReference type="GeneID" id="41358191"/>
    <dbReference type="KEGG" id="mxa:MXAN_0718"/>
    <dbReference type="eggNOG" id="ENOG5033B7C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168255_0_0_7"/>
    <dbReference type="OrthoDB" id="2002775at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046027">
        <property type="entry name" value="DUF5985"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="10475" checksum="9BD73115F08DDB9F" modified="2006-07-11" version="1">MMLKPMLNGAVAMAWLASALFFLRFWVQSKDRLFAFFALAFTMLAGNSVVAALLDVDDERRHYIYVVRLFAFLLILYAIWDKNRANRHGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF2</accession>
    <name>Q1DEF2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550831.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0703"/>
    <dbReference type="EnsemblBacteria" id="ABF91766">
        <property type="protein sequence ID" value="ABF91766"/>
        <property type="gene ID" value="MXAN_0703"/>
    </dbReference>
    <dbReference type="GeneID" id="41358176"/>
    <dbReference type="KEGG" id="mxa:MXAN_0703"/>
    <dbReference type="HOGENOM" id="CLU_1600922_0_0_7"/>
    <dbReference type="OMA" id="GWRARQW"/>
    <dbReference type="OrthoDB" id="1522824at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188206" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18033" checksum="C4A8FF50FBC5DA92" modified="2006-07-11" version="1">MAKMLTRGLLCAVLGMSPVAMAQDAEPAAAQVKAPDADAVRDTWNYFYKGQGQGPVLVEAKVCTEVAKEGPNKYECTAEVGPEGIKAGTSVMLWQAYLVPQGDSVEDIMVQSKQGAVVRETKDVKIKGEGWRARQWTGLRLNKPGTWTVSVLRGDQVLKEIQVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEI6</accession>
    <name>Q1DEI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550800.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89656">
        <property type="protein sequence ID" value="ABF89656"/>
        <property type="gene ID" value="MXAN_0669"/>
    </dbReference>
    <dbReference type="GeneID" id="41358144"/>
    <dbReference type="KEGG" id="mxa:MXAN_0669"/>
    <dbReference type="eggNOG" id="ENOG50319UP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102483_0_0_7"/>
    <dbReference type="OMA" id="AYAFETW"/>
    <dbReference type="OrthoDB" id="1226172at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20872" checksum="02DDD2078B40998E" modified="2006-07-11" version="1">MPEKLVFEHTLEGLFVRGLGARVTPVLRERLREVGVDLERKLQPAYAFETWCFAVRVAARELHPDVPDDVGYALLGERLVDGYRETVLGRAAFGVIQLLGPRRCVSRARQMFRSGNNYTETRLDDVSPTEVDLWMNEAGAIRYFTQGALRAGLRAVGAPHAEVQVRAFTDEGVTYRLTWRNGHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEY2</accession>
    <name>Q1DEY2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550654.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0522"/>
    <dbReference type="EnsemblBacteria" id="ABF89401">
        <property type="protein sequence ID" value="ABF89401"/>
        <property type="gene ID" value="MXAN_0522"/>
    </dbReference>
    <dbReference type="GeneID" id="41358006"/>
    <dbReference type="KEGG" id="mxa:MXAN_0522"/>
    <dbReference type="eggNOG" id="COG2372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502333_0_0_7"/>
    <dbReference type="OMA" id="TVEMTIG"/>
    <dbReference type="OrthoDB" id="606571at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="548" mass="57581" checksum="1E364AC19E05E013" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFB8</accession>
    <name>Q1DFB8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0383"/>
    <dbReference type="EnsemblBacteria" id="ABF86952">
        <property type="protein sequence ID" value="ABF86952"/>
        <property type="gene ID" value="MXAN_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0383"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1833007_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="15239" checksum="F83AFAB9A7021B0B" modified="2006-07-11" version="1">MSTAVACESTGWMLGSGAALVKSDSSGLGIGNTDRDEGGSGCSRRTRRAIWRWVTDAIKEHRHLRGPYVFCLDDGKPLTAHRMDRPLQHSLRRAGITREVGIIGWLDLRHTDASHLAMRGVPRRSAEGHSGSMGHTPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG4</accession>
    <name>Q1DFG4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550473.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0335"/>
    <dbReference type="EnsemblBacteria" id="ABF88162">
        <property type="protein sequence ID" value="ABF88162"/>
        <property type="gene ID" value="MXAN_0335"/>
    </dbReference>
    <dbReference type="GeneID" id="41357833"/>
    <dbReference type="KEGG" id="mxa:MXAN_0335"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_1_0_7"/>
    <dbReference type="OMA" id="WRVDLIP"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="31867" checksum="433DDF8CCF4446D8" modified="2006-07-11" version="1">MRLHLVDGTYELYRAHFSPRPGHAAPDGQDVKATVGLMSSLLALLHDADEAVTHVAVAFDNPIRSFRNALFDGYKSDEGVPPELHAQFDLAEEAVRALGVTAWSMKEQEADDALATAAARWADTVEQVRLLTPDKDLGQCVRGSRVVQVDRRQEKVLDEDAVRAKLGVPPASVPDLLALMGDAADGIPGLPGFGEKGASALLSAHGHLEDIPAEASEWKVRPRGAEKLAATLREHRDAALLYRRLATLVTDAPLPGTSSLEDLAWKGVPPAVYEAFCDRLGLTTLKRRPKRWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM2</accession>
    <name>Q1DFM2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribosome association toxin RatA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0270"/>
    <dbReference type="EnsemblBacteria" id="ABF88561">
        <property type="protein sequence ID" value="ABF88561"/>
        <property type="gene ID" value="MXAN_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0270"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079860_0_0_7"/>
    <dbReference type="OMA" id="GERTSHW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="3">
        <location>
            <begin position="110"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="28091" checksum="A65867310E54D550" modified="2006-07-11" version="1">MSPRGGRLGSQRWRRPGRGPQRTSEERLPQLVSALAGGALLTLGLRRGKLGGVAMALAGGGLLFRGTRTEQEPHVHKHGVVVRKLRRQRGRDATVELTVLQRSITIQGAPEALYRRWCDAETLNQVMGHFADVTSSGESLQHWKVPGVLGKELEWDAEVVEEHPGELLSWRSVGDTALPNEGWVRFRPAPRDWGTAVTLRFVFDPPGGVVGEKAVQLLGAVPAALALKALKRFKSLVETGEIPTTRPNPAAREGGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFQ4</accession>
    <name>Q1DFQ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550383.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0238"/>
    <dbReference type="EnsemblBacteria" id="ABF87352">
        <property type="protein sequence ID" value="ABF87352"/>
        <property type="gene ID" value="MXAN_0238"/>
    </dbReference>
    <dbReference type="GeneID" id="41357739"/>
    <dbReference type="KEGG" id="mxa:MXAN_0238"/>
    <dbReference type="eggNOG" id="COG3918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653500_0_0_7"/>
    <dbReference type="OMA" id="RIVAWHF"/>
    <dbReference type="OrthoDB" id="507317at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="1">
        <location>
            <begin position="39"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="263"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="46804" checksum="263CB2F5FF1EE8B0" modified="2006-07-11" version="1">MIEWRWFSGWTEEEMVPRLARARTLARNFPEVSGEMTLQGGWSQVRSESVLGRESPGRPVPGGLFERAQQVLETFDFSDPRIVAWHFSAEEPMQGRTVLLELRALGQQLRYLCGVRVGDTREEHDEVYSVFGFSFETLHGHIEAGREWFLLKKEHESGEVRFHIEAAWRPGQFPNGWSRLGFAMVAPRYQRAWHRLTHVRVRELALKHPEFVGQLTSHGRLAHSGHALGTAPVQFFAQRAPGRRETQLEEEIEAMNRGHGLRALGLGVLAGMRSMSAPALASRWLTKTQPDSEDRLARTLAHPWTPRVLGLLAVGELVADKLPMAPPRVAAVPLTGRMLSGALAAASVTTERQRGGRLAAAALGALAALASSWAFYSLRRTATKKLGVPDVAVALTEDALLAGLASRLLPVSEHQAGQATLSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG73</accession>
    <name>Q1DG73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89122">
        <property type="protein sequence ID" value="ABF89122"/>
        <property type="gene ID" value="MXAN_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0066"/>
    <dbReference type="HOGENOM" id="CLU_1925326_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="13430" checksum="9F9B7DE08B2DD196" modified="2006-07-11" version="1">MLAHEGPDAALARTLGHAHLGILPGQGHVAHVTAPELLAREVSAFLRESPARLGPTWTRTCLGRAASSRARASGPACPPSSRRPGSCAGPRPPPSPAPRSGHPSDSGGSAGCHTHGDTHRGPPVSSRTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGC0</accession>
    <name>Q1DGC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550169.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86164">
        <property type="protein sequence ID" value="ABF86164"/>
        <property type="gene ID" value="MXAN_0020"/>
    </dbReference>
    <dbReference type="GeneID" id="41357529"/>
    <dbReference type="KEGG" id="mxa:MXAN_0020"/>
    <dbReference type="HOGENOM" id="CLU_1164316_0_0_7"/>
    <dbReference type="OMA" id="CAWLGWL"/>
    <dbReference type="OrthoDB" id="1609858at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26505" checksum="6C0A4D650AE2FA2E" modified="2006-07-11" version="1">MRFLGWDLTDPYARIPRPVDVAEVDARGQVRFSELRWPVPSKALGFTPELLRASFPLNPEDVLVIDGPQALARPGASVREAERCLRAPGRTPDVLPEPGRPFAGFVRGGVLLFAALHARGGHPLLDVDTDSLEEARLFEAFPGATWRALSVEKLGKKTSHAGRTRRQAVLEARGLRFPPGLLPTHDQLDAALCAWLGWLTRKAPTHVTAVGAPLTVDNQGWLREGRILSSAHKFSTVKGLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVG1</accession>
    <name>Q1CVG1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yidC</name>
        <name evidence="16" type="ORF">MXAN_7509</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557411.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CVG1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7509"/>
    <dbReference type="TCDB" id="2.A.9.3.4">
        <property type="family name" value="the membrane protein insertase (yidc/alb3/oxa1) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90276">
        <property type="protein sequence ID" value="ABF90276"/>
        <property type="gene ID" value="MXAN_7509"/>
    </dbReference>
    <dbReference type="GeneID" id="41364642"/>
    <dbReference type="KEGG" id="mxa:MXAN_7509"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_3_0_7"/>
    <dbReference type="OMA" id="EHAPSFF"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="YidC_periplas" evidence="15">
        <location>
            <begin position="138"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="603" mass="65418" checksum="B711F84AB4C75398" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVT9</accession>
    <name>Q1CVT9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ORF">MXAN_7377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557289.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7377"/>
    <dbReference type="EnsemblBacteria" id="ABF88098">
        <property type="protein sequence ID" value="ABF88098"/>
        <property type="gene ID" value="MXAN_7377"/>
    </dbReference>
    <dbReference type="GeneID" id="41364536"/>
    <dbReference type="KEGG" id="mxa:MXAN_7377"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_7"/>
    <dbReference type="OMA" id="GHYWSGI"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="406" mass="44884" checksum="9FF9EEB65FDA5FF5" modified="2006-07-11" version="1">MSTEHAAPALSTRDFIDLEERYGAHNYHPLDLVIERGEGCWVHDVEGRKYLDCLSAYSAVNQGHCHPRILETLREQAAKVTLTSRAFRNDQLPHLYKALRELSGLSRALPMNSGAEACETAIKLARKWGYTVKGIPEDKAEVIVFANNFHGRTISLISFSTVRSYRQGFGPFTPGFTVVPYDDVEAVRRAITPNTCAILMEPIQAEAGVLIPRDGYLKQVAELCKQHRVLFMVDEIQTGLGRTGKTFAFQHEDVRPDVIVVGKALSGGFYPVSAVMADDEVMGVLRPGEHGSTYGGNPLGCAVARTALDVLRDERLVERSAEMGTSFLAMLKTLKNRHIVEVRGRGLMIGVALDISARPACEALMKEGVLCKETHDSVIRLTPPLIVTQAELDWAFERIKKVIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV6</accession>
    <name>Q1CVV6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ORF">MXAN_7359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557272.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7359"/>
    <dbReference type="EnsemblBacteria" id="ABF89792">
        <property type="protein sequence ID" value="ABF89792"/>
        <property type="gene ID" value="MXAN_7359"/>
    </dbReference>
    <dbReference type="GeneID" id="41364520"/>
    <dbReference type="KEGG" id="mxa:MXAN_7359"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920784_0_0_7"/>
    <dbReference type="OMA" id="CRGGYYV"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="42"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="32914" checksum="EC14103AFBE0F38F" modified="2006-07-11" version="1">MGGKLSPGIYRVHKPVGATSFSVVQRFMEEAKAVQPGKRIPVCHGGTLDPFAEGLLLVLVGQAPRLFELLHAVPKVYEAEVVWGTETDTGDLHGRPVLQGDTAALTPGALDAALASFVGWREQVPPATSAKKVGGEPAYRKAHRGEAVELPPSRVYLHAARWLSHDLPRASRLWLSCRGGYYVRSLARDVGRALGCGAHLSTLRRTAIGPWEDPGLGQRVWLHGRDLLPWARVRTLTDAEVGELRRERPVPASGLQPADWTLPPGFPDPEAPIRGFHQGCLAFLLRERDGALWSELELRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW30</accession>
    <name>Q1CW30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated protein Crm3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557199.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7280"/>
    <dbReference type="EnsemblBacteria" id="ABF85936">
        <property type="protein sequence ID" value="ABF85936"/>
        <property type="gene ID" value="MXAN_7280"/>
    </dbReference>
    <dbReference type="GeneID" id="41364445"/>
    <dbReference type="KEGG" id="mxa:MXAN_7280"/>
    <dbReference type="eggNOG" id="COG1769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044328_0_0_7"/>
    <dbReference type="OMA" id="GWYTSEV"/>
    <dbReference type="OrthoDB" id="1656967at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019117">
        <property type="entry name" value="CRISPR-assoc_protein_Cmr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09700">
        <property type="entry name" value="Cas_Cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="43985" checksum="C19CF65612A67253" modified="2006-07-11" version="1">MSDASFALLPRDGLSAKDGRGWYTSEVGRGYSLPWPLPTTVRGALRAAWGHDAMAVSGAVLAPDEWERCSEEVRLRHLVALRRPLGESFSLAHRMWPFPADAVCVRDADGSEHLERLEPRPDGAATLGPDDDDAREALWHPRRNSSGKPMAAPLFWPEARMMAWLRGAVEPSSETPDALTPRTDIHLAIDVETQASQDSMLHSREVVELLRLQRHSGRTPVLEEWALGLSCAWPAPASGAPRGPLGLGGRRRLSAVEPLKVDLFAIPDGVARATRGLRLVLATPAEFQRGWLPDGFERVAGTPPRYVGRLPCIDAPVVLRAALVPWPLDVSGWDMVRRRPRPTRRWVPAGAVYFFEKHSGGDFTANELRALWLASWGGGHAEALGQVLPGVWQPPRHGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW88</accession>
    <name>Q1CW88_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557141.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7222"/>
    <dbReference type="EnsemblBacteria" id="ABF92907">
        <property type="protein sequence ID" value="ABF92907"/>
        <property type="gene ID" value="MXAN_7222"/>
    </dbReference>
    <dbReference type="GeneID" id="41364391"/>
    <dbReference type="KEGG" id="mxa:MXAN_7222"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_10_7_7"/>
    <dbReference type="OMA" id="ERETSWE"/>
    <dbReference type="OrthoDB" id="1977684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187935" evidence="2">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="40789" checksum="3A27E63972EC1690" modified="2006-07-11" version="1">MQRFSASCVTVILFAVSFACSAGPRAEDGGNGAAEQGLFLSTPRKLLPFVVMESGRVLASGGHDGSRTLGSCEVFEPETGRWRETGALRTRRRNHAAVRLTDGRVLVMGGSNGLAMGALADAEVYAPDTGTWTEVRPMGVARNDPAAVLLADGRVLVAGGTDVDQRPLRSAELFDPATGMWSAASPPGFSRGGAQTAVVLANGKALFVSGLQAELYDPVTGLWEKAGLTGGAAGTHRLAHSVTLLPDGRVLVVGGTTARAAATAEVYSPETGVWTLVGAPKVPREHHATVVLPDGAVLMMGGEHYTTGALASVERFDLKTETWSSAPALDEPREKLGALALGDGAVLVMGGGNEAAGMLSESERYVPDACVVAPCAARELGGAEAVMELSVAGQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWC2</accession>
    <name>Q1CWC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557107.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7188"/>
    <dbReference type="EnsemblBacteria" id="ABF89249">
        <property type="protein sequence ID" value="ABF89249"/>
        <property type="gene ID" value="MXAN_7188"/>
    </dbReference>
    <dbReference type="GeneID" id="41364361"/>
    <dbReference type="KEGG" id="mxa:MXAN_7188"/>
    <dbReference type="eggNOG" id="COG4245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003679_0_0_7"/>
    <dbReference type="OMA" id="NHIVAAM"/>
    <dbReference type="OrthoDB" id="875369at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="31116" checksum="0DE45BD574A6B005" modified="2006-07-11" version="1">MTTHSNRFACARASGAGGALPSGEGEGARDMSSKANGSGIRKLFEDAHAEGVLSPAGLQALTVVDLGAQIQAGLGVCVEDVQSSEVVLVTVMPDDSGSIDYSGHSKTVCDGHNLVLDALLASKQKDGVLFHTRYLNGFVLNPYRPVEDVVRMHGKNYRADHGTPLYDQSVVLLGTVLAKAQEFSANGVPVRTVTLLITDGSDQHSTSAKAKDVAALVNDLKRAENHIVAAMGINDGSTDFRRVFREMGIDDKWILTPGQSAQEIRAAFQVFSQSAARVSQGAASFSRTALGGFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG0</accession>
    <name>Q1CWG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557069.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7150"/>
    <dbReference type="EnsemblBacteria" id="ABF91696">
        <property type="protein sequence ID" value="ABF91696"/>
        <property type="gene ID" value="MXAN_7150"/>
    </dbReference>
    <dbReference type="GeneID" id="41364324"/>
    <dbReference type="KEGG" id="mxa:MXAN_7150"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="QHIPTIF"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13694" checksum="D176B946E600B245" modified="2006-07-11" version="1">MKRLLIVDDELAIVEALQDILSVEGYDVDTAFNGAEGLHRMADAKPDLVLLDLMMPVMDGREMLRRMREDDGLRDIPVVVMSAGRISDEERRSSARFLAKPFELDVLLDTIAELLVEPQPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI3</accession>
    <name>Q1CWI3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_7127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557046.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7127"/>
    <dbReference type="EnsemblBacteria" id="ABF87524">
        <property type="protein sequence ID" value="ABF87524"/>
        <property type="gene ID" value="MXAN_7127"/>
    </dbReference>
    <dbReference type="GeneID" id="41364301"/>
    <dbReference type="KEGG" id="mxa:MXAN_7127"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309677_0_0_7"/>
    <dbReference type="OMA" id="SAYISCC"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="UnbV_ASPIC" evidence="12">
        <location>
            <begin position="869"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF87524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="955" mass="105716" checksum="3BB948B35551C192" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWS8</accession>
    <name>Q1CWS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556951.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7032"/>
    <dbReference type="EnsemblBacteria" id="ABF91091">
        <property type="protein sequence ID" value="ABF91091"/>
        <property type="gene ID" value="MXAN_7032"/>
    </dbReference>
    <dbReference type="GeneID" id="41364208"/>
    <dbReference type="KEGG" id="mxa:MXAN_7032"/>
    <dbReference type="eggNOG" id="ENOG5032KUN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083591_0_0_7"/>
    <dbReference type="OMA" id="WALISHE"/>
    <dbReference type="OrthoDB" id="1646345at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187996" evidence="2">
        <location>
            <begin position="26"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="289" mass="30667" checksum="F242DFC783554267" modified="2006-07-11" version="1">MFPIRTLLCALLALALGLGPTAAEARFGKRSRPSQSDSNRDRDRDDKEHGASAIGSDDDDDDDDAPRRPSRRRSSSNRRHVSGGSSTVTVSWLSYLFITGNHRMGVSPELRGERHAAAVSFRVGIQGGPLNEGGGGADLFLGLEGRRFGVDLRLTGLGLPTDDGTSGSDSITLTQSHLTWALISHERARLRAEAGVSTAHAPDITFVGPSFGASLEACIIGPLDLEARLQVTPFPYRQVDANAALALKLGAVVLRGGYRGMVLDDAGYVDGVSNVDTFHGPFLGLGLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX17</accession>
    <name>Q1CX17_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6941"/>
    <dbReference type="EnsemblBacteria" id="ABF89684">
        <property type="protein sequence ID" value="ABF89684"/>
        <property type="gene ID" value="MXAN_6941"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6941"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_62_7"/>
    <dbReference type="OMA" id="PEQWRRY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CHASE" evidence="9">
        <location>
            <begin position="124"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="351"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="574" mass="63623" checksum="F332BE68AB73678F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX53</accession>
    <name>Q1CX53_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556826.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6906"/>
    <dbReference type="EnsemblBacteria" id="ABF92727">
        <property type="protein sequence ID" value="ABF92727"/>
        <property type="gene ID" value="MXAN_6906"/>
    </dbReference>
    <dbReference type="GeneID" id="41364088"/>
    <dbReference type="KEGG" id="mxa:MXAN_6906"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_18_1_7"/>
    <dbReference type="OMA" id="DTMGDFM"/>
    <dbReference type="OrthoDB" id="1745184at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="24516" checksum="26F22B913F9D18A4" modified="2006-07-11" version="1">MAAKNTPSDAPARPVRRTQQERRETTRRKLLDATIETLVEQGYARLTTVEVSKRAGLSQGALFTHFDTKEELLAAAVEHLFPRLIQDYLAGVGARPSGRDRIAAAVDMLWAAFQRPELQAAIELYVAARTDAELRVALAAVDGPHRENLHRVARELFPEASEHPDFDSIVELALDAVQGAAVGGSARPNDPAHRRMLDALTHFMRNAFLPSLTRPRRRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXB3</accession>
    <name>Q1CXB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556768.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6843"/>
    <dbReference type="EnsemblBacteria" id="ABF88540">
        <property type="protein sequence ID" value="ABF88540"/>
        <property type="gene ID" value="MXAN_6843"/>
    </dbReference>
    <dbReference type="GeneID" id="41364032"/>
    <dbReference type="KEGG" id="mxa:MXAN_6843"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033631_2_0_7"/>
    <dbReference type="OMA" id="WAMATAW"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="415" mass="46654" checksum="90A4413E404D4612" modified="2006-07-11" version="1">MSINVYAVATPFVIVLALGEFAYCVIRRNGYYAFQDSIASMGTAVLNQCVNVAVALLVLPLFIQLGQFAPWQLGASSPLELVALFLGVDFLFYWFHRFGHRTNIGWAAHSPHHSTEELNYAVALRASVTQRLFSFLFYWPLVLVGFPPEAVLAMVAFHLVLQFIPHTRVIPKMPRWIESWLNTPSHHRVHHARNDVYIDKNYAGFLIIWDKLFGTFEEEKEACSYGLTSPPNTWDPTVINFQAWGKLVSDAVATKSHWDRLRIWVMPTGWRPADLPPRASVGWQKDGVELKFQSTELPGARGYLVFQLLAAMPFMLLVSHHASPLSGWQKLVLSLLFWAMATAWSGMLESRRWSLPLELGRVLAMGAAVTWWLIHASAPQSWTALCAAWMGVSLVWLVVVRGASQGATPVPQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXG0</accession>
    <name>Q1CXG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556721.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6796"/>
    <dbReference type="EnsemblBacteria" id="ABF92399">
        <property type="protein sequence ID" value="ABF92399"/>
        <property type="gene ID" value="MXAN_6796"/>
    </dbReference>
    <dbReference type="GeneID" id="41363986"/>
    <dbReference type="KEGG" id="mxa:MXAN_6796"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083309_0_0_7"/>
    <dbReference type="OMA" id="VDRHWNL"/>
    <dbReference type="OrthoDB" id="705269at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26038" checksum="694DD31CDEB3E254" modified="2006-07-11" version="1">MIGPLLKEWRTLRGKSQLALSLEAQVSARHLSFLESGRSGASQELVLRLAEALGLGLRDRNALLVAAGFAPQFGERGWHSAELAEVRRAAGLILASHEPYPAIVVDSSSTVLEANAGALAMMGQPREALGQVNLMDLVFVPGPVRSAIGNWEEIAGYLLHRLREGARMRGPRSPVASVLAHVLAQPGVEALTALRPANAGSVLVPLTFTRDGATTHWYTTLTSFGAPQDALVEEITIEQFHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM2</accession>
    <name>Q1CXM2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556659.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6734"/>
    <dbReference type="EnsemblBacteria" id="ABF86025">
        <property type="protein sequence ID" value="ABF86025"/>
        <property type="gene ID" value="MXAN_6734"/>
    </dbReference>
    <dbReference type="GeneID" id="41363926"/>
    <dbReference type="KEGG" id="mxa:MXAN_6734"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="VYRWHLA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="252"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="376"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="438"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="671" mass="74163" checksum="787F99BF2BBB7F5F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY0</accession>
    <name>Q1CXY0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556551.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6625"/>
    <dbReference type="EnsemblBacteria" id="ABF89370">
        <property type="protein sequence ID" value="ABF89370"/>
        <property type="gene ID" value="MXAN_6625"/>
    </dbReference>
    <dbReference type="GeneID" id="41363822"/>
    <dbReference type="KEGG" id="mxa:MXAN_6625"/>
    <dbReference type="HOGENOM" id="CLU_1617237_0_0_7"/>
    <dbReference type="OMA" id="EAHSHPP"/>
    <dbReference type="OrthoDB" id="1753047at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18047" checksum="5BDE93F5CFDA2433" modified="2006-07-11" version="1">MITRRLSAVMPLALCLLLSPGCDKGPDQLRDAEKSYRDLIDRRVSPLDPAWDPVINAFEAIPKDSKVRPEAEQRIAAIRRLRGKLPPRPLATPGATGPGTSEVDTKRAACEALAIRLGQTPEGADREPLHQALTDCQKELVRLEAHSHPPGEHGHDHGGEPGHPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYP2</accession>
    <name>Q1CYP2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556289.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6357"/>
    <dbReference type="EnsemblBacteria" id="ABF92692">
        <property type="protein sequence ID" value="ABF92692"/>
        <property type="gene ID" value="MXAN_6357"/>
    </dbReference>
    <dbReference type="GeneID" id="41363570"/>
    <dbReference type="KEGG" id="mxa:MXAN_6357"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_7"/>
    <dbReference type="OMA" id="CNDNMLA"/>
    <dbReference type="OrthoDB" id="1034540at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="468" mass="50236" checksum="2C176E95AD8187EA" modified="2006-07-11" version="1">MSTAALPADFLQAITEGFPADFLTREPGELQEYGRDWTRVYAPAPAAVALPRTTDEVARLLALCHQHHIAVVPSGGRTGLAGGAVAARGELVLSLQRMTRMGPVDLLGNTVRVQAGAVTEAVHHHCAEHGLTWPVDFASKGSSTVGGNIATNAGGVKVIRYGLTRQWVLGLQVVTAQGEVLELNGALEKNNTGTDLRQLFIGSEGTLGVITEATLKLTQLPGKQDVFLFAVPDVAAVLRLFRDARRQNAFSISAYEFFTDRCMARLGRHRKLRPPFETPSECYVLLEAEAKDAAAVEGWLGSLFERELVTDGVQAQGAAQAAELWALREGISESLSATGLPHKNDISLPVAGLEAFCAELEALFSARYPGWEICLFGHIGDGNLHVNVMKPDAMDKAEFLAHTKQADPTMFALVQKHGGSISAEHGVGLLKKDYLGYSRAPAELALLRTLKRALDPRGILNPGKVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYQ6</accession>
    <name>Q1CYQ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556275.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6342"/>
    <dbReference type="EnsemblBacteria" id="ABF92968">
        <property type="protein sequence ID" value="ABF92968"/>
        <property type="gene ID" value="MXAN_6342"/>
    </dbReference>
    <dbReference type="GeneID" id="41363557"/>
    <dbReference type="KEGG" id="mxa:MXAN_6342"/>
    <dbReference type="HOGENOM" id="CLU_1011306_0_0_7"/>
    <dbReference type="OMA" id="AWDFRIE"/>
    <dbReference type="OrthoDB" id="1526872at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="30242" checksum="3D01E9DEB5FFEF42" modified="2006-07-11" version="1">MFHGSPSTLLRPALLLTALSLFLTGCFNVEQDVWIEPGGSARLVVDMGVPRSLTALARLGNAPVSKEQWLASARAVEQALRQDPEVSQVMLRDYEKDGQVHLVYDVTVKDVTQLPELYRRAAEQHTQGQPSSPKDAWDFRIERQGGDYVYTQRFNPEKAFATPVGIGDEAAEQAAQELAKGMVKAMLVNNRLTLRIHGPGIGETNGTVNEQKDTVEWKLNLAELMDAPAEGREFRAVIHGGEPLWLWPLVLGVPMVVLLLTVTAARKRRGVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYY3</accession>
    <name>Q1CYY3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556203.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6261"/>
    <dbReference type="EnsemblBacteria" id="ABF87021">
        <property type="protein sequence ID" value="ABF87021"/>
        <property type="gene ID" value="MXAN_6261"/>
    </dbReference>
    <dbReference type="GeneID" id="41363484"/>
    <dbReference type="KEGG" id="mxa:MXAN_6261"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028398_5_1_7"/>
    <dbReference type="OMA" id="TIYHRIL"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03487">
        <property type="entry name" value="RT_Bac_retron_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="48070" checksum="5EF9C5095E04D0D2" modified="2006-07-11" version="1">MSWFDTTLSRLKGLFSRPVTRSTTGLDVPLDAHGRPQDVVTETVSTSGPLKPGHLRQVRRDARLLPKGVRRYTPGRKKWMEAAEARRLFSATLRTRNRNLRDLLPDEAQLARYGLPVWRTEEDVAAALGVSVGVLRHYSIHRPRERVRHYVTFAVPKRSGGVRLLHAPKRRLKALQRRMLALLVSKLPVSPQAHGFVPGRSIKTGAAPHVGRRVVLKLDLKDFFPSVTFARVRGLLIALGYGYPVAATLAVLMTESERQPVELEGILFHVPVGPRVCVQGAPTSPALCNAVLLRLDRRLAGLARRYGYTYTRYADDLTFSGDDVTALERVRALAARYVQEEGFEVNREKTRVQRRGGAQRVTGVTVNTTLGLSREERRRLRAMLHQEGRSEDVEAHRAHLDGLLAYVKMLNPEQAERLARRRKPRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ45</accession>
    <name>Q1CZ45_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91403">
        <property type="protein sequence ID" value="ABF91403"/>
        <property type="gene ID" value="MXAN_6197"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6197"/>
    <dbReference type="HOGENOM" id="CLU_3404485_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="30" mass="3566" checksum="026D616E0E94BC52" modified="2006-07-11" version="1">MQAKVEREVERDLVYTLRRLCDPSGSERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB6</accession>
    <name>Q1CZB6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gst</name>
        <name evidence="4" type="ORF">MXAN_6122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556071.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6122"/>
    <dbReference type="EnsemblBacteria" id="ABF87712">
        <property type="protein sequence ID" value="ABF87712"/>
        <property type="gene ID" value="MXAN_6122"/>
    </dbReference>
    <dbReference type="GeneID" id="41363356"/>
    <dbReference type="KEGG" id="mxa:MXAN_6122"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_6_1_7"/>
    <dbReference type="OMA" id="YVATELH"/>
    <dbReference type="OrthoDB" id="1246633at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="22324" checksum="9C903EBB20417902" modified="2006-07-11" version="1">MKLFYSPGACSLSPHIILREGGFSFTTEKVDIRAKKTAAGEDFHAINPKGYVPALQLDDGSLLTEGPAIVQFLADQVPDKKLAPANGTLERYRLQEMLNFISTEIHKGFSPLFNPAFPDDVKRLTRERLAQRLGVLEVVVAKQAFLLGDQFTVADAYLFTTLNWAGHTKVDLEPFPALRAYHARVADRPSVQEALKAEGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE8</accession>
    <name>Q1CZE8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556039.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="TCDB" id="1.B.75.1.7">
        <property type="family name" value="the duf481 putative beta barrel porin (duf481) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89304">
        <property type="protein sequence ID" value="ABF89304"/>
        <property type="gene ID" value="MXAN_6090"/>
    </dbReference>
    <dbReference type="GeneID" id="41363326"/>
    <dbReference type="KEGG" id="mxa:MXAN_6090"/>
    <dbReference type="eggNOG" id="COG3137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057310_0_0_7"/>
    <dbReference type="OrthoDB" id="923515at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007433">
        <property type="entry name" value="DUF481"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04338">
        <property type="entry name" value="DUF481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="34807" checksum="D20FBF5D4D94032F" modified="2006-07-11" version="1">MLSAAFLIATSLQAQTPAPTSSTPPAPAAETAPAAPLSVEERAAIAAERAAIAAERAAEASARAAEAAERAAAATVPPPAAAAAAAPATDKKQGEWDVTVGLGLISLTGNASTLTVSGLASAQRTTDHWIYAIKSYGSYGRSRPPEVTGEEAVSQVVAFNAGLELRGDRRFTDVISGYLLGGAETDHVKSVESRTFGEGGLGVLWWDEKKEKGRESYLRTDAAFRYANETRFQYYPTRMNLPDVDLGGPRFGAVFRYGLAQNVTFKEDVEVLVSVIGDSRMLFNSQTQLSVGLTKQLSLGTSFLVKHDSAPPPGKVSTDTALALNFEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW7</accession>
    <name>Q1CZW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfA</name>
        <name evidence="7" type="ORF">MXAN_5919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555870.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5919"/>
    <dbReference type="EnsemblBacteria" id="ABF90025">
        <property type="protein sequence ID" value="ABF90025"/>
        <property type="gene ID" value="MXAN_5919"/>
    </dbReference>
    <dbReference type="GeneID" id="41363157"/>
    <dbReference type="KEGG" id="mxa:MXAN_5919"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="LFVRPIY"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="33399" checksum="08D757E70959A843" modified="2006-07-11" version="1">MPIVLIVAEQQPDGNLRKATLNAISAGKQLAEKAGGELHIALVGKDPSKVADELKGYGAKAVHLGAAAELEHYLAETYAPAIAALAQELKADYIGMASTAQGKDLLPRVAGRLRAAMATDVMAINGSGADITFTRPMWAGNVFADVKLTTPVKVLTLRATEFPAAAGGQGAAEVKTFSPKVEASKTKFVDFKEVKSARPELTEARVVISGGRGTKGDFKEIEGLADDLGAAVGASRAVCDAGWVPNDLQVGQTGKVVAPALYIAAGISGAIQHLAGMKSSKTIVAINKDPEAPIFQVADYGMVADLFKVLPELRAELAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D072</accession>
    <name>Q1D072_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555765.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5814"/>
    <dbReference type="EnsemblBacteria" id="ABF87773">
        <property type="protein sequence ID" value="ABF87773"/>
        <property type="gene ID" value="MXAN_5814"/>
    </dbReference>
    <dbReference type="GeneID" id="41363054"/>
    <dbReference type="KEGG" id="mxa:MXAN_5814"/>
    <dbReference type="eggNOG" id="COG5394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089210_2_0_7"/>
    <dbReference type="OMA" id="RYTNRKL"/>
    <dbReference type="OrthoDB" id="1665699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012909">
        <property type="entry name" value="PHA_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07879">
        <property type="entry name" value="PHB_acc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB_acc_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="225" mass="25184" checksum="331AB0D427620B83" modified="2006-07-11" version="1">MSEAEQAGAPSKEPKIIKRYTNRKLYDTVESRYVTLDEIAAMIKEGTEVRIVDNRTKEDLTSVTLAQIIFEEEKKKNQMPLSVLREIIRHPGESISGFIQKEVSPRVASIREEAESRLDKLLRRDENAPRAEGEPEAPVAAAEDTAAADTAAAAGLSPADLLKASQRAFEEWQRRIDERVKHVVENLTGNLPALGRDMASLTQRLDELEKKLEQAEQQKGPPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H7</accession>
    <name>Q1D0H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555660.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5708"/>
    <dbReference type="EnsemblBacteria" id="ABF85841">
        <property type="protein sequence ID" value="ABF85841"/>
        <property type="gene ID" value="MXAN_5708"/>
    </dbReference>
    <dbReference type="GeneID" id="41362953"/>
    <dbReference type="KEGG" id="mxa:MXAN_5708"/>
    <dbReference type="eggNOG" id="COG2940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124044_1_0_7"/>
    <dbReference type="OMA" id="LNYVFYG"/>
    <dbReference type="OrthoDB" id="1675945at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062122">
        <property type="term" value="F:histone methyltransferase activity (H3-K37 specific)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009207">
        <property type="entry name" value="SET7_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022536">
        <property type="entry name" value="A612L_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="15720" checksum="310017E5A0080542" modified="2006-07-11" version="1">MNQGAALYIHPGVKVRPCEWGYGVFTDAFIKAGDLIEECHYLKLPRALSQNPQLQDYVFLLQWARHEVPREGEWVALVLGYGMIYNHAREPNTSYHREATRDVFCYHALRDIHPGEQLCISYGEDWWASRDQGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0L7</accession>
    <name>Q1D0L7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555621.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88195">
        <property type="protein sequence ID" value="ABF88195"/>
        <property type="gene ID" value="MXAN_5668"/>
    </dbReference>
    <dbReference type="GeneID" id="41362913"/>
    <dbReference type="KEGG" id="mxa:MXAN_5668"/>
    <dbReference type="eggNOG" id="ENOG5032TJX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146077_0_0_7"/>
    <dbReference type="OrthoDB" id="1854586at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="13997" checksum="755177B072AFB6EB" modified="2006-07-11" version="1">MSSRDTAAREAAMNHKTHERHDHVHAKGCGHPAIQHQDHVDYLHDGHLHHPHSDHTDECTLAEDARNPAQCTPQHACGAHEATHRHGPSCGHAAAPHGDHMDYLVDGHLHHPHDGHCDDHGKVQVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V0</accession>
    <name>Q1D0V0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555538.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5584"/>
    <dbReference type="TCDB" id="3.A.1.144.3">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87664">
        <property type="protein sequence ID" value="ABF87664"/>
        <property type="gene ID" value="MXAN_5584"/>
    </dbReference>
    <dbReference type="GeneID" id="41362831"/>
    <dbReference type="KEGG" id="mxa:MXAN_5584"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="TSAFNCI"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="33517" checksum="05CF21EDB3B888FF" modified="2006-07-11" version="1">MSGIHVQDLGKRFGDRVAVEALSFHVRPGEVFGLLGPNGAGKTTTVRMLTGLLQPTEGEATVWGHRVDRDGEPLRKVVGLLTEQPGLYDRLTARENLRFFMKLHELDEAAAWPRARHYLERFGLGGREEEPVGGFSKGMRQKLAIVRTLVHDPKVIFLDEPTSGLDPESARTVRDAVAELASEGRTIVLCSHNLAEVERLCERVAVVKRRLLAMGPVRELRHAGQALEVRVEGEAERFCLALAQLPFAPNVLAEGPKLRVMLADDAQAPDVVACLVGAGARVHSAVPTQRPLEEVYLELLREGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D103</accession>
    <name>Q1D103_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555485.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5527"/>
    <dbReference type="EnsemblBacteria" id="ABF90947">
        <property type="protein sequence ID" value="ABF90947"/>
        <property type="gene ID" value="MXAN_5527"/>
    </dbReference>
    <dbReference type="GeneID" id="41362780"/>
    <dbReference type="KEGG" id="mxa:MXAN_5527"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_11_2_7"/>
    <dbReference type="OMA" id="WGSTART"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="17596" checksum="322701FFB8ABF9B3" modified="2006-07-11" version="1">MNNKNPSSSAATLPEGPRLSLALVTKDAPAALDFYTRAFGAREKYRLTEPSGRVGHAEMDLGGVTLMLADEYPEYDILSPQSRGGTTCSLNLRVDDVDAAAQRAIDAGATLERPIQDEFYGERSAHLRDPFGHRWALNARIENVSPEEMQRRFTRMLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1N8</accession>
    <name>Q1D1N8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90648">
        <property type="protein sequence ID" value="ABF90648"/>
        <property type="gene ID" value="MXAN_5283"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5283"/>
    <dbReference type="HOGENOM" id="CLU_1925329_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="14283" checksum="65A1EB6F1DDB0CB4" modified="2006-07-11" version="1">MLTRPNGTRGSRSRREHAPASRSVPESTGTDGGRVAWRDLRPCRPRRRGACGRESPSCGTRPGQEPWPREHPSAASSAARTPRWSRARAASANLSLSTPPPEAVAYFSDRGLTLERQLRMLHLSSLSSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1S3</accession>
    <name>Q1D1S3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555215.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92261">
        <property type="protein sequence ID" value="ABF92261"/>
        <property type="gene ID" value="MXAN_5248"/>
    </dbReference>
    <dbReference type="GeneID" id="41362527"/>
    <dbReference type="KEGG" id="mxa:MXAN_5248"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860044_0_0_7"/>
    <dbReference type="OrthoDB" id="2133965at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188158" evidence="2">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="34116" checksum="5B03F69EB8437483" modified="2006-07-11" version="1">MLPSRVFLLIPLIILFGVSSAWAQPYERTQYEGLELCRGDRTVTYAMTTSGGHPTAEERAAVTAAFNTWNQAVASCSDLVFTPGEDVPHPAPRPLDGKMLVTFRQVNCPDIVPDDDACWQNESCHDKYDCWPFAPRDVVDETSYFRVSTGEILGTEISLNNSNGMLTTLDGPPCDEGVIEPGCVIGDVQSLVTRSIGEGLGLALLTRTDSTMSRVLPWGDTQKRIIDPGTLQGICETYPRGLPTPGCIISTDGGVPDGGDGVPSGDGGVQEADGGVPDAGDSVPDGDGGAPSKSGCTTTSSVPLLGALMLLLGARRTRQRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D258</accession>
    <name>Q1D258_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555085.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5111"/>
    <dbReference type="EnsemblBacteria" id="ABF88206">
        <property type="protein sequence ID" value="ABF88206"/>
        <property type="gene ID" value="MXAN_5111"/>
    </dbReference>
    <dbReference type="GeneID" id="41362395"/>
    <dbReference type="KEGG" id="mxa:MXAN_5111"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169663_0_0_7"/>
    <dbReference type="OMA" id="VGPWFPL"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="27399" checksum="D7D64C53D0DF1608" modified="2006-07-11" version="1">MSKHPRSKGGRLSAGLKLIGPLCISVGLLVGLRLLGPQYLDQQTLSGWLRPLGALAPLAFILLLAVRPVTLLPGQLFTAVGGILFGMAAGTVYALVGTLLASGLIHLLARRLGRKPMRRLAGDKHPVFERAAREHGFQLGFLACINSVIPADVMLATASASGARYVPLALGAVVGTLPGTLLTALFGSSLGQGKTWMTAVSATGMVVSLLLGLVLGRKLMRELLAKEAAVASGGPGRVHPGPGDVRPTGSRRPGAAPCLPAAPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D296</accession>
    <name>Q1D296_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5658 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555048.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5073"/>
    <dbReference type="EnsemblBacteria" id="ABF89920">
        <property type="protein sequence ID" value="ABF89920"/>
        <property type="gene ID" value="MXAN_5073"/>
    </dbReference>
    <dbReference type="GeneID" id="41362357"/>
    <dbReference type="KEGG" id="mxa:MXAN_5073"/>
    <dbReference type="HOGENOM" id="CLU_154542_0_0_7"/>
    <dbReference type="OMA" id="YHLAFLT"/>
    <dbReference type="OrthoDB" id="1806573at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043717">
        <property type="entry name" value="DUF5658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18902">
        <property type="entry name" value="DUF5658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5658" evidence="2">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="15050" checksum="61E709C1C3FB11FE" modified="2006-07-11" version="1">MATDWRRGMGVAATIGQMRGGAWGNRASFYLSPASVALLMLNLLDGLFTLFFLQLGVAEELNPIMREAYEQSPLFFMFSKLVIVNAGLWLLCIHRHLKASRIAIRLGAAVYAVIVVYHLAFLTHLVMHWPQMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2P4</accession>
    <name>Q1D2P4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4923"/>
    <dbReference type="EnsemblBacteria" id="ABF86873">
        <property type="protein sequence ID" value="ABF86873"/>
        <property type="gene ID" value="MXAN_4923"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4923"/>
    <dbReference type="HOGENOM" id="CLU_2047163_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="120" mass="14201" checksum="8515D149E55E54E6" modified="2006-07-11" version="1">MMSSVENEFRGILNAIKLYQNDRLYNEYDGLCQLIADLAPYFTYNANYPASQYPSQKLPYSSAYFTIALAIYSARWRYFDQIYASAPWPAKREAFRLWVAETHIQSNRIATWRYRDEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2U9</accession>
    <name>Q1D2U9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554849.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4866"/>
    <dbReference type="EnsemblBacteria" id="ABF86354">
        <property type="protein sequence ID" value="ABF86354"/>
        <property type="gene ID" value="MXAN_4866"/>
    </dbReference>
    <dbReference type="GeneID" id="41362157"/>
    <dbReference type="KEGG" id="mxa:MXAN_4866"/>
    <dbReference type="HOGENOM" id="CLU_1309037_0_0_7"/>
    <dbReference type="OMA" id="QEVKRTW"/>
    <dbReference type="OrthoDB" id="1213684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188065" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="22008" checksum="BFD7483D40ADF990" modified="2006-07-11" version="1">MKALASLALCASFVLPTVASAQQPTTAQGDRPAVTFDEIERGIYFAVLGGPLFITNPPAAEGTPRPFSSGPMAQVEVGVDLGEHVSVGLFLMGSSVRTGAQYVGNSGGAVSGDFSTLIPGAVLRARLVGFADSQEVKRTWFYLRAGAGYAMFSPQRLLPDSDILVFAGPGVEYYTRLRHFSVGLEVTGQYLVSGGSFGFAVAPNIRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Y4</accession>
    <name>Q1D2Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4828"/>
    <dbReference type="EnsemblBacteria" id="ABF89235">
        <property type="protein sequence ID" value="ABF89235"/>
        <property type="gene ID" value="MXAN_4828"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4828"/>
    <dbReference type="HOGENOM" id="CLU_3404484_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="30" mass="3393" checksum="C291175F90EF1BE5" modified="2006-07-11" version="1">MPAVKHLTQRAPEIRGATSRCLATHPRHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D311</accession>
    <name>Q1D311_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554787.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4801"/>
    <dbReference type="EnsemblBacteria" id="ABF90693">
        <property type="protein sequence ID" value="ABF90693"/>
        <property type="gene ID" value="MXAN_4801"/>
    </dbReference>
    <dbReference type="GeneID" id="41362100"/>
    <dbReference type="KEGG" id="mxa:MXAN_4801"/>
    <dbReference type="eggNOG" id="COG3521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1576816_0_0_7"/>
    <dbReference type="OMA" id="VPQACET"/>
    <dbReference type="OrthoDB" id="1864732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017734">
        <property type="entry name" value="T6SS_SciN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038706">
        <property type="entry name" value="Type_VI_SciN-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37625">
        <property type="entry name" value="PTHR37625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12790">
        <property type="entry name" value="T6SS-SciN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03352">
        <property type="entry name" value="VI_chp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187835" evidence="2">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="22844" checksum="4B4FDD7ADCE51396" modified="2006-07-11" version="1">MWSAGRNLRWGVVIALAAALSGSAGCVKRVPQACETPPPFQVVVDASEQLNPDARGRSLPTVVQIVQLKDSVRLERAGFKDLWGKPEEFLKEDLLQVAELVIPPGRQVKRWVQRDPKARFVLAMGHFRQPLGYSWRTVAALPVVEEARCVERPAGDQGDPKPGDEVFRYRLQGYQIDLMFRPMTQAPEPRLQPQAGDGVSPRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D334</accession>
    <name>Q1D334_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator phoP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP1</name>
        <name evidence="6" type="ORF">MXAN_4777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554764.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D334">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4777"/>
    <dbReference type="EnsemblBacteria" id="ABF92342">
        <property type="protein sequence ID" value="ABF92342"/>
        <property type="gene ID" value="MXAN_4777"/>
    </dbReference>
    <dbReference type="GeneID" id="41362076"/>
    <dbReference type="KEGG" id="mxa:MXAN_4777"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_7"/>
    <dbReference type="OMA" id="DNVWGYQ"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24793" checksum="EAE00E00391C3EC1" modified="2006-07-11" version="1">MSRILIIEDEQDLAGLVDYNLRAAGFETETASTGASGLAKARAHPPDLVLLDLMLPDVAGSEVLRMLKADTELRKASVIIVSAKGQESDRVQGLELGADDYVVKPFSVRELLLRVKAVLRRADAEDGPSAVLASGDISLDTTRHQVRVKGEEVLLTALEFRLLRTLLERSDRVQTREVLLSDVWGIQAEIHTRTVDTHIKRLREKLGPAGDIIETVRGVGYKLSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3C2</accession>
    <name>Q1D3C2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4685"/>
    <dbReference type="EnsemblBacteria" id="ABF88097">
        <property type="protein sequence ID" value="ABF88097"/>
        <property type="gene ID" value="MXAN_4685"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4685"/>
    <dbReference type="HOGENOM" id="CLU_660407_0_0_7"/>
    <dbReference type="OMA" id="PADFHTW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="398" mass="43557" checksum="37F98EA7FDB91CC1" modified="2006-07-11" version="1">MLSSNGQYVPQEVELKTISDIVGLKGTVADLQGGARIVIDSQDPDLNNATTPEGYANALLKNAGRDVSANYISQGGVLWPADFHTWNMVTAYYSMERAYDYFRVVGNIPAADFKDPVTTYYFPEFVLADVDKDPLSDNAMYFSVLESFLMLPFDKLQRAPLAINAGIIAHEYAHRVFNLKAYNGQQFPEALSLWQQAGASPGANILKSFDEGLADYHAYGSTCQTTQGGKGCDTRFFSTSFHGNLYGQVTEDRDLARVDRCMDASLLNQLYNQNLSAFSGNEYRVGTLLASALYQAGEATGQRDVLLRAIVASYNDESTTTPGLYQLARATLADQSRFTLAVAASAIITHITDLRLKEAVCNELMDHLQIPREQLVGNDPNMCPPSAAGGTTCPRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D6</accession>
    <name>Q1D3D6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_4671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554663.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4671"/>
    <dbReference type="EnsemblBacteria" id="ABF85990">
        <property type="protein sequence ID" value="ABF85990"/>
        <property type="gene ID" value="MXAN_4671"/>
    </dbReference>
    <dbReference type="GeneID" id="41361971"/>
    <dbReference type="KEGG" id="mxa:MXAN_4671"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_2_7"/>
    <dbReference type="OMA" id="SIMKWCG"/>
    <dbReference type="OrthoDB" id="357522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="40"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="166"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="291"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="476"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF85990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="614" mass="66318" checksum="BB1063ED7E9F82B2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3V3</accession>
    <name>Q1D3V3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4501"/>
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        <property type="gene ID" value="MXAN_4501"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_4501"/>
    <dbReference type="eggNOG" id="COG3501">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="23993" checksum="5A8C929131BB52E7" modified="2006-07-11" version="1">MTDTAHAQERRLLGAMLGTYLAKVVSVEDPEHLARVKVRLLTAPEGLADADVALWARVAVPFSGSGWGALFLPDKDDEVAVVFAGGDPRQPLVVGGLWNGRARPPETPGGNRVDRYVIKARNGSRIAIVEASEGTAQITLEVPGGVSATLKQANGGELTLEAAGNTVTLAQQGVTVRAATTVSVTASQVEVSAGQVTVNAAMSSFSGVVKCDTLQTNSVMGVTYTPGAGNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D416</accession>
    <name>Q1D416_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretory system II protein E, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554435.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4436"/>
    <dbReference type="EnsemblBacteria" id="ABF86923">
        <property type="protein sequence ID" value="ABF86923"/>
        <property type="gene ID" value="MXAN_4436"/>
    </dbReference>
    <dbReference type="GeneID" id="41361748"/>
    <dbReference type="KEGG" id="mxa:MXAN_4436"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032809_0_0_7"/>
    <dbReference type="OMA" id="PEFRMNQ"/>
    <dbReference type="OrthoDB" id="1277557at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="2">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="431" mass="46538" checksum="6ECDD2E4A83FDB40" modified="2006-07-11" version="1">MRLGEQLLKDGLVTAEGLEEALEAQVVHGGRLGTNLVELGLLSEVDLAKALGKVHNSAFASGEMVPDPKAMELVSSNHADDKEYLPMRVDATRLSIAVVNPHDFSTLDAIAFKTGKRVVPVVIPEFRMNQLLRRYCKAFRPLRAVDMNAVRPRPSAGSQAELAKAAETPPDLMSEEEFQSVYASALRGGADSDGDMGEEEIITGVEVLEAAPEPPPATVRPQVPVAPPPPPQAIAVPPQMVQPHVPPPAPALGGSPPPVQVPRAPEPPPTPLTFAEAQAELARSSDREDVAHTVLRFALGKWKRNLLLSVQGSLVTGWHGMGVGVRDAVVRRIGVPLREQSTFRLVRDTRSHYIGPVRRDAAMGVFYKLLGDGFPKTAVILPLLVRGKVVHLLYVDNGPDQLTPPDVGELLILSQSVGRSYEAMMRRRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D426</accession>
    <name>Q1D426_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4426</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554425.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4426"/>
    <dbReference type="EnsemblBacteria" id="ABF89761">
        <property type="protein sequence ID" value="ABF89761"/>
        <property type="gene ID" value="MXAN_4426"/>
    </dbReference>
    <dbReference type="GeneID" id="41361738"/>
    <dbReference type="KEGG" id="mxa:MXAN_4426"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_7"/>
    <dbReference type="OMA" id="AGPWHFA"/>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="38596" checksum="EED3686EC66F0711" modified="2006-07-11" version="1">MKRAVKLLASLLVTFLFMWWAFRDTDWATQLASLKSANYAWLVPYFGCLLAIHVFRTLRWGCLLSGLEQVPFRKLNEASGIGFMMLLVLPFRLGEFARPFLIAQRSGIRRSAAMTSVVLERIVDGLFVAAMLRALLFFVPTETPEIRYVKLGSWLMFAVFGGGLAFLLFGLWQQQRTVNLVRATVGRLAPQVADKVADIVDTFVGAMRQLPKGRQVALFFLYTALYWGVNGAGMSMLANAFDCSGAAPGTVCEPMDLTLFQAYVVLGVLVVGLMIPAAPGMMGTFQAATKVGLSLFLPAAAVNASGLAYANVMWLSQTVQQVGLGLILLSMGHLSFKDIAGKLDDKDGEAAAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D442</accession>
    <name>Q1D442_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnosyl O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rhamnosyl O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554409.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89897">
        <property type="protein sequence ID" value="ABF89897"/>
        <property type="gene ID" value="MXAN_4410"/>
    </dbReference>
    <dbReference type="GeneID" id="41361723"/>
    <dbReference type="KEGG" id="mxa:MXAN_4410"/>
    <dbReference type="eggNOG" id="COG3510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868272_0_0_7"/>
    <dbReference type="OrthoDB" id="1831745at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007072">
        <property type="entry name" value="Rhamnosyl_O-MeTrfase_CmcI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04989">
        <property type="entry name" value="CmcI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="36484" checksum="136CADF8B6DDB82C" modified="2006-07-11" version="1">MDSCEACIKKQPAGRWLESHGPGHTVGCFQQPPMPGGARLQEEVRRFIADVQRDHTYSGVNTYLGNTVMKTLLPLLQRAATEQVAPPDDQTVRMMEMFHAHLRRRVQGRLVDYFERPPLLGRDVPDTVFALSQGVSDCMRWRGIPLFKTVYDLALYPRLLSDLRPRTIFESGSANGGGALWLADQLTALELDCHIHTYDLVKPDVSHPRVSFMQGDSHKIQKVFTPELLRAAPHPWLFIEDAHVNVDGILTYLHEYLRPGDYVIVEDPESGRVSGEESLVEDQLGRFLWHHREAYRVDTFYTDFFGYNASCAMDAIFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D454</accession>
    <name>Q1D454_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554397.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4396"/>
    <dbReference type="EnsemblBacteria" id="ABF88513">
        <property type="protein sequence ID" value="ABF88513"/>
        <property type="gene ID" value="MXAN_4396"/>
    </dbReference>
    <dbReference type="GeneID" id="41361706"/>
    <dbReference type="KEGG" id="mxa:MXAN_4396"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301662_0_0_7"/>
    <dbReference type="OMA" id="HAHHSEW"/>
    <dbReference type="OrthoDB" id="26246at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="989" mass="104448" checksum="D3E2A94F6F96E5C6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4I9</accession>
    <name>Q1D4I9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554262.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4259"/>
    <dbReference type="EnsemblBacteria" id="ABF86390">
        <property type="protein sequence ID" value="ABF86390"/>
        <property type="gene ID" value="MXAN_4259"/>
    </dbReference>
    <dbReference type="GeneID" id="41361574"/>
    <dbReference type="KEGG" id="mxa:MXAN_4259"/>
    <dbReference type="HOGENOM" id="CLU_1609057_0_0_7"/>
    <dbReference type="OMA" id="IFGCIAR"/>
    <dbReference type="OrthoDB" id="1850852at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045629">
        <property type="entry name" value="DUF6232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19744">
        <property type="entry name" value="DUF6232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17445" checksum="AB4C14D8F96772B1" modified="2006-07-11" version="1">MIEPLAVSAVPATPAFPDRPLVAPPAPSEVPLFQDAGLRVTTERIVARGKTLLLADVQRVETVRRTPRMVPVLATLGLCMSVGLPALSALSVSSSTAKGGYEAALIAVVMVIFGCIARLVLAEESYRLVLHTRAGSWRVRASKDPKSLMLLAGLIQDAVAARGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4V6</accession>
    <name>Q1D4V6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Frizzy aggegation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frzB</name>
        <name evidence="2" type="ORF">MXAN_4142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D4V6"/>
    <dbReference type="IntAct" id="Q1D4V6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4142"/>
    <dbReference type="EnsemblBacteria" id="ABF91972">
        <property type="protein sequence ID" value="ABF91972"/>
        <property type="gene ID" value="MXAN_4142"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4142"/>
    <dbReference type="HOGENOM" id="CLU_1968160_0_0_7"/>
    <dbReference type="OMA" id="IGDSEYG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="112" mass="12115" checksum="1C2407F577FA3EE1" modified="2006-07-11" version="1">MDLLFFDIGATLYGTDASQVLRIDRALPEDLTLAELGLPHRGNRAIVFDTPEGEAHLKVDAVHGVRSIPVNSLRRMPPTAGAAAYAVGVCLEEARTVLLIDLVETARTQGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4W1</accession>
    <name>Q1D4W1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554140.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4137"/>
    <dbReference type="EnsemblBacteria" id="ABF85886">
        <property type="protein sequence ID" value="ABF85886"/>
        <property type="gene ID" value="MXAN_4137"/>
    </dbReference>
    <dbReference type="GeneID" id="41361456"/>
    <dbReference type="KEGG" id="mxa:MXAN_4137"/>
    <dbReference type="HOGENOM" id="CLU_2221620_0_0_7"/>
    <dbReference type="OMA" id="EGTDPGM"/>
    <dbReference type="OrthoDB" id="1712653at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013433">
        <property type="entry name" value="PHA_gran_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09650">
        <property type="entry name" value="PHA_gran_rgn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="106" mass="11678" checksum="654303275037A7BA" modified="2006-07-11" version="1">MGMMKFDIPHSLPKEEVKQRVDQLLQYWGGKYGVKADWQGEGAKIVGKVMGIQMDASFVITDKAVEGEGTDPGMLLRGQAKSYLQKKFGSVLDPSKSLDQVKSSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4X1</accession>
    <name>Q1D4X1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554130.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4127"/>
    <dbReference type="EnsemblBacteria" id="ABF88234">
        <property type="protein sequence ID" value="ABF88234"/>
        <property type="gene ID" value="MXAN_4127"/>
    </dbReference>
    <dbReference type="GeneID" id="41361449"/>
    <dbReference type="KEGG" id="mxa:MXAN_4127"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_2_0_7"/>
    <dbReference type="OMA" id="RDWAGMM"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="414" mass="45405" checksum="5A3D3B1F458CFC84" modified="2006-07-11" version="1">MAQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTYDEIVALLHDPRVSSDIRNLVRQAGATPSPQEGPPGLPEPFIRRDPPDHDRLRKLAMRPFGPPHTPGRIDALRPWLVETTTGLLDALAGKNQVDIVGDVAYPFPVTVICKLLGVPREDEARFHELADAGVETLDPTTGTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSGFLTDNGPDGRMSREEVLSTAALLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPELSIPLVEELLRYEPPVQFLPDRVTLADIDIAGTTIPQGSPLVLMLAAGSRDPERFDDPDRFMPDRPNNSHLGFGSGIHYCFGAPLARLEAQIALTELACRLEHPRLVADPPPYRPNPALRGPLHLLVEVDGIRAAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D540</accession>
    <name>Q1D540_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554062.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4055"/>
    <dbReference type="EnsemblBacteria" id="ABF88200">
        <property type="protein sequence ID" value="ABF88200"/>
        <property type="gene ID" value="MXAN_4055"/>
    </dbReference>
    <dbReference type="GeneID" id="41361385"/>
    <dbReference type="KEGG" id="mxa:MXAN_4055"/>
    <dbReference type="eggNOG" id="ENOG50311G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265818_0_0_7"/>
    <dbReference type="OMA" id="FKSSWVE"/>
    <dbReference type="OrthoDB" id="1355909at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="24307" checksum="106453898194465E" modified="2006-07-11" version="1">MPDTVGMSAASVAETEIAKKALSVPPGTFRHTVLTAAKRFKSTWAELGKLLVQVRDEAKFEEWGYPSFETYCLKELHIKKQTALKLTRSFSFLTKHEPEEELTAQEFPQRAPAFEVIEVLADAEERGQLSPTEYKSLRDSIWSPEKNPAELKKEFAERFPRPPPEPPPESAQVRKLAQMARKLASELSGSRRIPNAVAERAAALAEDLEDIASGVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D590</accession>
    <name>Q1D590_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554013.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4003"/>
    <dbReference type="EnsemblBacteria" id="ABF92556">
        <property type="protein sequence ID" value="ABF92556"/>
        <property type="gene ID" value="MXAN_4003"/>
    </dbReference>
    <dbReference type="GeneID" id="41361334"/>
    <dbReference type="KEGG" id="mxa:MXAN_4003"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_7"/>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="36382" checksum="27D2974EE6DFF272" modified="2006-07-11" version="1">MKYTNLGRTGLRVSRLGLGCMSYGTPKWRPWVLDEEAAQPFFRRAVELGINFFDTADMYSLGASEEITGRALRRYARMDEVVLATKVYFPMGDGQNMRGLSRKHIVQGCEASLKRLGVEAIDLYQIHRMDPNTPLEETLAALDQLVRQGKVRYLGASSAYAWQFARALGVADLRGWTRFVSMQGHYNLVYREEEREMLPLCEAEGIGVIPWSPLARGLLAGSRKSLKDRDATTRAKSDTLSPMLYDQASDWDVAEANRSVAEKRNVPPAQTALAWLLSRPAVTAPIIGATKLEHLEDAVRAVDLKLTADEVKALEAPYQPHAVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A9</accession>
    <name>Q1D5A9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein QmcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553994.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3984"/>
    <dbReference type="EnsemblBacteria" id="ABF87475">
        <property type="protein sequence ID" value="ABF87475"/>
        <property type="gene ID" value="MXAN_3984"/>
    </dbReference>
    <dbReference type="GeneID" id="41361316"/>
    <dbReference type="KEGG" id="mxa:MXAN_3984"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_7"/>
    <dbReference type="OMA" id="AMNMQLK"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="368" mass="40152" checksum="5221FF3E39567358" modified="2006-07-11" version="1">MEIVTIFGIFAVILVGIAATGIRIVPQAKVMVVERLGKFYKTASSGLNYLIPFVDAPRAIEMRTGNRFMRSNLVDLREQVMGFDTVQVITHDNVNMEVGSVIYYQIVEPAKALYQVENLALAIEQLTMTNLRNIMGGLTLDQTLTSRETVNTKLRIVLDEATEKWGVKVTRVELREIEPPQAIKAAMAKQMTAERERRAEVTKAEGDKAAAILQAEGEKISRILRAEAERDAEIARAEGHKRATMLQAEGKAEATRLVFEAIHNGRATPEVLALRYMETLQELGKGDNKIFVPYEATATLGAVATLKEVFAQTGDAAKPAPAPARSAASLSGQAIARNTVVPEHATLPGGTPAVAPRRPRPALDTQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5H8</accession>
    <name>Q1D5H8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_3915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553925.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3915"/>
    <dbReference type="EnsemblBacteria" id="ABF92759">
        <property type="protein sequence ID" value="ABF92759"/>
        <property type="gene ID" value="MXAN_3915"/>
    </dbReference>
    <dbReference type="GeneID" id="41361246"/>
    <dbReference type="KEGG" id="mxa:MXAN_3915"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969469_0_0_7"/>
    <dbReference type="OMA" id="ARVMIDI"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="220"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF92759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="30882" checksum="D03072E51BC592E9" modified="2006-07-11" version="1">MRVRTILNFELPEPAADAASSVLAQPTGALFRMGDAAGVEGFWSRWSGAVVVAVVLHAVVVAAGLSVSPASPKKVVREEPELVLLAFAAPPPPPPAGGGGAQPAAKKEVQRQARPKPAQRVMPTPVPRPERVAEVKPETPPEPEPVVEPEPAPEPTVAKAEPASASSEASAVGGVVGGVVGGVVGGTQGGIVGSTAIGGTGDALTLKQVMRPPTVLKQVRPDYPRLAKQRNIQGVVVVRVIVGTDGRVEQEHTQVMRSVPALDAAAIAAVNQWHFTPALGRSGRLARVMIDIPVNFSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5I2</accession>
    <name>Q1D5I2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3911"/>
    <dbReference type="EnsemblBacteria" id="ABF91847">
        <property type="protein sequence ID" value="ABF91847"/>
        <property type="gene ID" value="MXAN_3911"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3911"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="TAPFMEG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="25342" checksum="9D7BEA2D79266683" modified="2006-07-11" version="1">MHVAFDEGRRRVLAGLTAEVSTKELTFIAGASGTGKSVLCRLAVGLLRPDAGEVVLWGERVDSRPERELVPLRRQAPYLVQGPALLDWRTLRQNVWLADPAASVDDVDAALAQVGLLDWADRLPPELGPGAKKRTAIARALVLKPRYLLFDEPTTGLDRKAAGQVEEALASLKARGLGGMVVSHDYRQLKALADRVLVVANKQCAYLGTPKGFLESSAPELRVLTAPFMEGATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5S8</accession>
    <name>Q1D5S8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553825.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3813"/>
    <dbReference type="EnsemblBacteria" id="ABF87887">
        <property type="protein sequence ID" value="ABF87887"/>
        <property type="gene ID" value="MXAN_3813"/>
    </dbReference>
    <dbReference type="GeneID" id="41361145"/>
    <dbReference type="KEGG" id="mxa:MXAN_3813"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_1_1_7"/>
    <dbReference type="OMA" id="WIDGQAR"/>
    <dbReference type="OrthoDB" id="1966598at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="22206" checksum="F55CF11B5178585C" modified="2006-07-11" version="1">MSPTKKAAAKKAPTAELPTIAFASPAEWASWLEANHASSRGLWLKLAKKGSGIESVTYAEAVDVALEWGWIDGQKNAFDDTAWLQKFTPRGAKSVWSKINCEKVEALIAAGRMKPSGMEVVALARQDGRWDAAYESPSKATVPEDLARALAANAKAAAFFATLNAANRYAILWRVHTAKKAETRARRIEQFVEMLARHESLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V0</accession>
    <name>Q1D5V0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553804.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3791"/>
    <dbReference type="EnsemblBacteria" id="ABF86970">
        <property type="protein sequence ID" value="ABF86970"/>
        <property type="gene ID" value="MXAN_3791"/>
    </dbReference>
    <dbReference type="GeneID" id="41361123"/>
    <dbReference type="KEGG" id="mxa:MXAN_3791"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_7"/>
    <dbReference type="OMA" id="YEAGRSM"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="7">
        <location>
            <begin position="273"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="393" mass="40714" checksum="B8E0EDFACE261262" modified="2006-07-11" version="1">MARDVVIVGAARTPIGAFQGALAKLTAPQLGAIAIKAALERAGVKPEAVQEVILGCVLTAGVGQAPARQAAIFAGLPETVPATTLNKVCGSGLKAVSAGAQAIALGDADVVVVGGMESMSNAPYISHTMRGGARMGNVEFKDAMIHDGLWDVYGNVHMGICAEECATTQDISRSQQDEYALESTRRAIQAQKEGLFKAEIVPVQIPGKKPEDVVTVSDDEGPRNAKPEKIPGLKPVFKKDGTVTAANASSINDGAAALVLMSEERAKAEGRAILGRITGYAQAARKPVEFTIAPTDAINKLLKKQGISAGDVDLWEINEAFAVVSIANNRLLGLDVSKVNVRGGAVALGHPIGASGARVLVTLLQTMQDLDKKRGVASLCIGGGEGIALMVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5W8</accession>
    <name>Q1D5W8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553786.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3773"/>
    <dbReference type="EnsemblBacteria" id="ABF92186">
        <property type="protein sequence ID" value="ABF92186"/>
        <property type="gene ID" value="MXAN_3773"/>
    </dbReference>
    <dbReference type="GeneID" id="41361105"/>
    <dbReference type="KEGG" id="mxa:MXAN_3773"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="HIIFFIQ"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="300"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="420"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="712"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="806" mass="85067" checksum="11758F7E45AFC550" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D698</accession>
    <name>Q1D698_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M19 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553656.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3638"/>
    <dbReference type="EnsemblBacteria" id="ABF93147">
        <property type="protein sequence ID" value="ABF93147"/>
        <property type="gene ID" value="MXAN_3638"/>
    </dbReference>
    <dbReference type="GeneID" id="41360975"/>
    <dbReference type="KEGG" id="mxa:MXAN_3638"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363985_0_0_7"/>
    <dbReference type="OMA" id="CHKFDNA"/>
    <dbReference type="OrthoDB" id="167885at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188265" evidence="1">
        <location>
            <begin position="23"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="640" mass="69066" checksum="DD9EA9484D4E5084" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6A4</accession>
    <name>Q1D6A4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase-like monooxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553650.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3632"/>
    <dbReference type="EnsemblBacteria" id="ABF86702">
        <property type="protein sequence ID" value="ABF86702"/>
        <property type="gene ID" value="MXAN_3632"/>
    </dbReference>
    <dbReference type="GeneID" id="41360970"/>
    <dbReference type="KEGG" id="mxa:MXAN_3632"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_0_7"/>
    <dbReference type="OMA" id="PPFVLAM"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="37274" checksum="C5626B76393B3EB4" modified="2006-07-11" version="1">MKLSVLDHSIVASDSQTRAAFQNTVELARAAEQLGYHRFWLAEHHGSGHFAGVAPEILVAHVAAATSRIRVGTGGVLLSNYSPFKVAEVFRLLETLHPNRIDLGIGRTSGSTDLVARALAYGPPMNNENFPTKLEDLVAFLSGTTPATPEFEKLSLKTMAPGMPQVWALGSGEQSAALAARLGLSFCFAHFFNPIHGGPVTRGYRERFQPSHVQAAPNSAVSVYVICAPTEQEARRIARSSDLLTINTRRGRPEAPIPSIEEAEAYAYTPEDLATLEFDRKRVVCGSPDQVKEQLLRMAAEFQADELLVTTIVHDHRARMRSYELLADAFSLSSTPPAAQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6J1</accession>
    <name>Q1D6J1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase, flavoprotein subunit</fullName>
            <ecNumber evidence="13">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sdhA</name>
        <name evidence="13" type="ORF">MXAN_3539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="13"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3539"/>
    <dbReference type="EnsemblBacteria" id="ABF90355">
        <property type="protein sequence ID" value="ABF90355"/>
        <property type="gene ID" value="MXAN_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3539"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_1_7"/>
    <dbReference type="OMA" id="FGYWRET"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="10"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="482"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="626" mass="69244" checksum="4BB36B145B1B217A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N6</accession>
    <name>Q1D6N6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3492"/>
    <dbReference type="EnsemblBacteria" id="ABF91160">
        <property type="protein sequence ID" value="ABF91160"/>
        <property type="gene ID" value="MXAN_3492"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3492"/>
    <dbReference type="HOGENOM" id="CLU_1863024_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="SSF48484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoxygenase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="15065" checksum="3668EA5335C673B3" modified="2006-07-11" version="1">MSSRDYCAASCEAERHAGGNSNASSTSSFPHSTTSTASRAQRFPTSVKTRPQLTELMTMFVWQFSVQHTVVNEEAYNHAAFAPNASTRMYAPPAGKPSSKWSPADVIACMPSQTRNYPDLRDMNIRARRPPGLIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E3</accession>
    <name>Q1D7E3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3231"/>
    <dbReference type="EnsemblBacteria" id="ABF90556">
        <property type="protein sequence ID" value="ABF90556"/>
        <property type="gene ID" value="MXAN_3231"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3231"/>
    <dbReference type="eggNOG" id="COG5653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046277_3_0_7"/>
    <dbReference type="OMA" id="TRGFYTE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="167"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="358" mass="40641" checksum="605A0E83D8480A84" modified="2006-07-11" version="1">MTGRAAFISLESEWNALVEVTSNELFYRHEFIRIWMDNFVPGVIPRVLTLRDTDGSLGAVLPLWEERTTLLGVPARQLSVAANAHSCRFDLVAKEPEVAAAAFVSHLRSAGGWDVLRLTDVPDGGAAWRLHAVARESGLPVGEWESLRSPYVPLPATRDALQKTLQSKFKANCRRRRRKLEEKGQLTFERVDSGLGLEGALEEGFLLEQSGWKGARGTAMAQDARTRGFYTELARDSAYRQRLALYFLRLDGRPVAFQYGLEYGGRYFLLKPGYDESLRECSPGQLLVDEVIGNCIDRGLHEFDFLGPDMVWKRDWTNEVRRHTWLYVFNDSPFGQALCAAKFRWGPAVKEVVSRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F7</accession>
    <name>Q1D7F7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ActC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553262.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3215"/>
    <dbReference type="EnsemblBacteria" id="ABF89691">
        <property type="protein sequence ID" value="ABF89691"/>
        <property type="gene ID" value="MXAN_3215"/>
    </dbReference>
    <dbReference type="GeneID" id="41360569"/>
    <dbReference type="KEGG" id="mxa:MXAN_3215"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626754_0_0_7"/>
    <dbReference type="OMA" id="MGDYFDL"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="BRENDA" id="2.3.1.B34">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="273"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="46763" checksum="CCFFFC301DC885B7" modified="2006-07-11" version="1">MTPPLVLLGSGYTLTRLAVAEARAGRDVLAATRDAARRAELERAGARVTDLEDALTRTAGAHVVVSVPPDAGLDTRIASALAGQVPARLVYLSSTGVYGRARGHVDEDTPVELSTPSSRERIEAESRYLPLGAMVMRIAGIYGPGRGIHTRLLSGALRLPEGGGGRISRIYVDDLVESIRVVLTRGEPGALYCVADDRSAPSEEPVAWLSQRLGVPMPPRIPLAQLNETLRGDRDISNARLKSLGWAPRYPDFISGYTALLKAEGHGAGPTQLVIRRLVAEDAEAFKALRLRGLRDNPESFAASVEEDSALSLEAVRGWLVGASQCVLGAFDGGQLVGALGLNRESRARLAHKAMVWGMYVAPEVRSRGVGRRLLTALIDEARKMGGLKCLLLAVSVGNAPAHALYRSLGFRTYGVEPNALKVGETFLDEELMVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J0</accession>
    <name>Q1D7J0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3180"/>
    <dbReference type="EnsemblBacteria" id="ABF86107">
        <property type="protein sequence ID" value="ABF86107"/>
        <property type="gene ID" value="MXAN_3180"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3180"/>
    <dbReference type="HOGENOM" id="CLU_625329_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="438" mass="46664" checksum="2A55120879C64FCF" modified="2006-07-11" version="1">MFYTVVGREVLLLRRALCLFDEPGEVAGLLEGPDKLVGVLVQLDLNFIGELPLTVAPADSLFPRNAIGRWIHEQHPREHRQILPRTASTKRSDDGPLPTLPDDGRRRFRAAAMEGHARRLCDTLAKFRELNPCDSRRNMVDAGVVGSNLEEFARLLLDAVTSRNYALLAALVVVVLVDLLRKFGGGFIPFFNTDRGGAVLVLGVSLAGAVANALAAGAPFTLALLLTALQVALTAAGGFTIIKRILFRSAAIARAELAGALAAGQVAEKAARLPSWSNSTPGAASEARRARAGRTARASRVGLRGHQRRARSALPRWRHSSRRGGGRLLAVGKPLHSNRFGDCAAASRERIVTPAGGGRVLHGRRCGLACRAWGRVRRCEARELIVGGYGIGAVGLGPRDAVNYVLTAAARTPSYIGGTNKPRVGQGGTARHTGRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Z3</accession>
    <name>Q1D7Z3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="2">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">coaE</name>
        <name evidence="3" type="ORF">MXAN_3021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553077.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3021"/>
    <dbReference type="EnsemblBacteria" id="ABF87898">
        <property type="protein sequence ID" value="ABF87898"/>
        <property type="gene ID" value="MXAN_3021"/>
    </dbReference>
    <dbReference type="GeneID" id="41360382"/>
    <dbReference type="KEGG" id="mxa:MXAN_3021"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_0_0_7"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="198" mass="21344" checksum="107AF32B3800B9C5" modified="2006-07-11" version="1">MHVFGLTGGIASGKSTVTRILRELGAEVLDADVIAREVVEPGTPGLAAVAARFPGVVGSDGRLDRVRLGARVFGDPAERAALNDITHPLVRQAFMDKLQALEERGVARVIYDVPLLIESGMHTWMEAVAVVWVPRAMQKARLMSRDGLDSDAADARLAAQLPLDDKRAHATWVIDNSGDLASTRAQVEAMWRAMLARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8B5</accession>
    <name>Q1D8B5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fvmX3-analog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552958.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2897"/>
    <dbReference type="EnsemblBacteria" id="ABF87830">
        <property type="protein sequence ID" value="ABF87830"/>
        <property type="gene ID" value="MXAN_2897"/>
    </dbReference>
    <dbReference type="GeneID" id="41360265"/>
    <dbReference type="KEGG" id="mxa:MXAN_2897"/>
    <dbReference type="eggNOG" id="ENOG5032K2A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465805_0_0_7"/>
    <dbReference type="OMA" id="MEHEDEH"/>
    <dbReference type="OrthoDB" id="1918967at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045483">
        <property type="entry name" value="fvmX3-analog"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20002">
        <property type="entry name" value="fvmX3-analog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="fvmX3-analog" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="88" mass="9543" checksum="48DD38A53CB31E8E" modified="2006-07-11" version="1">MASLILRLQVDPATGRKDVIIQYESDADALPMEHEDEHRRLVDSLIQGGTLKASELGRVIVQRDTPSGKAAEPTSTAEDASEKVSQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D9</accession>
    <name>Q1D8D9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2873"/>
    <dbReference type="EnsemblBacteria" id="ABF91630">
        <property type="protein sequence ID" value="ABF91630"/>
        <property type="gene ID" value="MXAN_2873"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2873"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037852_0_0_7"/>
    <dbReference type="OMA" id="YATEVMD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187983" evidence="1">
        <location>
            <begin position="27"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="53"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="553" mass="57852" checksum="121605932542A766" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8S3</accession>
    <name>NUOB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name type="ordered locus">MXAN_2733</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552800.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8S3"/>
    <dbReference type="SMR" id="Q1D8S3"/>
    <dbReference type="STRING" id="246197.MXAN_2733"/>
    <dbReference type="EnsemblBacteria" id="ABF87142">
        <property type="protein sequence ID" value="ABF87142"/>
        <property type="gene ID" value="MXAN_2733"/>
    </dbReference>
    <dbReference type="GeneID" id="41360110"/>
    <dbReference type="KEGG" id="mxa:MXAN_2733"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_7"/>
    <dbReference type="OMA" id="GWARKYS"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000376287" description="NADH-quinone oxidoreductase subunit B">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <sequence length="187" mass="20871" checksum="0C7496C44DA75F5C" modified="2006-07-11" version="1">MADADLANIVTTRRDESMGWLQSIVSKGLGWARKYSLFTYPYATACCGMEYMSVAASRHDISRFGAEFPRFSPRQADLLMVVGTINLKQAPILKRVYEQMAEPKWVVAFGVCASSGGFYDNYAVLQGIDRIIPVDVYIPGCPPRPEQVLDGLMLLQDKIGNQVHRIAEREEANPTAARHNLLLSMNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8V5</accession>
    <name>PUR5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="1">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purM</name>
        <name type="ordered locus">MXAN_2701</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552769.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8V5"/>
    <dbReference type="SMR" id="Q1D8V5"/>
    <dbReference type="STRING" id="246197.MXAN_2701"/>
    <dbReference type="EnsemblBacteria" id="ABF92152">
        <property type="protein sequence ID" value="ABF92152"/>
        <property type="gene ID" value="MXAN_2701"/>
    </dbReference>
    <dbReference type="GeneID" id="41360079"/>
    <dbReference type="KEGG" id="mxa:MXAN_2701"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_7"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258372" description="Phosphoribosylformylglycinamidine cyclo-ligase">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <sequence length="345" mass="35858" checksum="0B94449A50C37F14" modified="2006-07-11" version="1">MGTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAGTDGVGTKLKVAFAAGRHGTVGIDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVVKGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGVVERAAIIDGKSVKPGDALIGLPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVKVKGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMGLGLILVVAKEDVAQALSVLSGRGVQAFEVGRVEAGQGEATAVIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D935</accession>
    <name>Q1D935_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2619"/>
    <dbReference type="EnsemblBacteria" id="ABF90419">
        <property type="protein sequence ID" value="ABF90419"/>
        <property type="gene ID" value="MXAN_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2619"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035406_0_0_7"/>
    <dbReference type="OMA" id="ELAPAWC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="49088" checksum="E2E94B2BE6C2DC37" modified="2006-07-11" version="1">MLTRPWFFCYGFRIDTPGAVMVVLRSFVIALSAAMLLGAAEPSAAARAAFVRGESALARGRWDDAATAYREALADTPGYPSALNGLGSVLFRKGQVQEALTLFRDAAKADPGFKMAWFNLGYAARKTGDAATAAQAYERYTELEPGDADGFYGLGESYRQLGQKDKAIPAYQAYIAREQRKGEQVWVRKATEHLKAMGAEPLAVATAPASATPSAAPAAESVTSNPALAASRIRDGDALMKERRYREAAFAFLDASHADGGHVEALFKLGNALAVLGYYGQAVAQWERATALTKDAAIQQSAKENIDRARAKMVQAGVSPQAAGQAPGSGPVADTTRALARRAYEQGVQRIASKDFSGALTSLTQSIQLEPMLTVAFVARGSANIGLRRYAEAAADYQYALELEPGSASPLYGLAESFRAMGRTLEARDLYERYAASSSADVRPQLQEESRQKAARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D981</accession>
    <name>Q1D981_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552643.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2573"/>
    <dbReference type="EnsemblBacteria" id="ABF90581">
        <property type="protein sequence ID" value="ABF90581"/>
        <property type="gene ID" value="MXAN_2573"/>
    </dbReference>
    <dbReference type="GeneID" id="41359951"/>
    <dbReference type="KEGG" id="mxa:MXAN_2573"/>
    <dbReference type="eggNOG" id="ENOG5030SQT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303804_0_0_7"/>
    <dbReference type="OMA" id="MVDGTER"/>
    <dbReference type="OrthoDB" id="1290912at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="23362" checksum="F6CB01924320604E" modified="2006-07-11" version="1">MSADRDIDEWMAARGITLPEARARTRAVLEEVGLTRPGRQRMSEPKLLKAAELLAGRFFSVCADGACLKVAQASGREPMRIEPRLHCERCGGSANRRAEVAFVEACQRYGVRRVVVVGGSPAVREELEAKLGHQIDLRMVDGTERRTADRARSDLDWADLVLVWGATELHHKVSGHYTHGGPAYSHKVVHVVKRGVAALLEEGITHLERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D999</accession>
    <name>Q1D999_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ORF">MXAN_2555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552625.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2555"/>
    <dbReference type="EnsemblBacteria" id="ABF90033">
        <property type="protein sequence ID" value="ABF90033"/>
        <property type="gene ID" value="MXAN_2555"/>
    </dbReference>
    <dbReference type="GeneID" id="41359933"/>
    <dbReference type="KEGG" id="mxa:MXAN_2555"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_7"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="30043" checksum="325AFF96FAB698EF" modified="2006-07-11" version="1">MERPSVISTLEQAVKARPMPRHVGIIMDGNGRWAESRGLPRLEGHREATSSVREVTRTARRLGIQALTLYAFSSQNWARPAEEVAGLMDLLREYLERERSEILDNGIRLNAIGDVDRLPRYVRDPLDRLRADSAHNTGMVLSLALSYGGREEILHAARRLAEAVERGELAAGRLEESDFEQFLWTQGLPPLDLMVRTSGELRVSNFLLWQMAYAEMCFTDALWPDFRTDEFLRCVSQYQQRERRFGLTSAQVQREDAPQQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B8</accession>
    <name>Q1D9B8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552606.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2536"/>
    <dbReference type="EnsemblBacteria" id="ABF88081">
        <property type="protein sequence ID" value="ABF88081"/>
        <property type="gene ID" value="MXAN_2536"/>
    </dbReference>
    <dbReference type="GeneID" id="41359914"/>
    <dbReference type="KEGG" id="mxa:MXAN_2536"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_7"/>
    <dbReference type="OMA" id="NGWHHTG"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="604" mass="66702" checksum="8383350F655B3C96" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9G1</accession>
    <name>Q1D9G1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88020">
        <property type="protein sequence ID" value="ABF88020"/>
        <property type="gene ID" value="MXAN_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2493"/>
    <dbReference type="HOGENOM" id="CLU_3330552_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="38" mass="4077" checksum="715DB2D773DBE380" modified="2006-07-11" version="1">MICSSRVMPRSPCARRGSGRAQGAQYIGPPFQVVVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Q8</accession>
    <name>Q1D9Q8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552470.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2395"/>
    <dbReference type="EnsemblBacteria" id="ABF88366">
        <property type="protein sequence ID" value="ABF88366"/>
        <property type="gene ID" value="MXAN_2395"/>
    </dbReference>
    <dbReference type="GeneID" id="41359779"/>
    <dbReference type="KEGG" id="mxa:MXAN_2395"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_7"/>
    <dbReference type="OMA" id="NAKVQFH"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="23942" checksum="B655E6ABC488B5D0" modified="2006-07-11" version="1">MSIRETGGQVVSLPARMARAGLERAPDEALCRAFLEGDPAAFEVLVTRHRSLVFSLVRRYVTRPEDAADLVQSAFLRALEASRRVFARFTPSGPAPFRAWLVRIALNLAKNHARQVQRWRPVLVASGPDDVVEDPSESAQDRLERAERERQVRAEVLALPRRQREVLTLRVDGGLAFKDIAETLGITENNAKVQFHHAMKRLKARVGAPEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9T0</accession>
    <name>Q1D9T0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M38 (Beta-aspartyl dipeptidase) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552448.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2373"/>
    <dbReference type="EnsemblBacteria" id="ABF86019">
        <property type="protein sequence ID" value="ABF86019"/>
        <property type="gene ID" value="MXAN_2373"/>
    </dbReference>
    <dbReference type="GeneID" id="41359758"/>
    <dbReference type="KEGG" id="mxa:MXAN_2373"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_4_2_7"/>
    <dbReference type="OMA" id="VTTVCDM"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="92"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="467" mass="50398" checksum="9D2CF7169E10B7C4" modified="2006-07-11" version="1">MKHPLRHVWGRLLLAGALTTGLLACQGRQGLRSEDSEKVTVLRGVRVIDGRGGAPLENAAVVIQGTTLQRVGPVDEVEVPASATVIELPGRTVLPGLISNHSHLGMTRGTDSGGQNYQRDNIARQLTQWESYGVTTVTSLGLNTPLIYELQKEVEQGTLPGASILSGDQGIGVPEGAPPMKVVEHQLYRPATPDEARQDVRETASRHPAFVKVWVDDFGGTVKNKMTPEVYTAVIDEAHRQGLRVAAHIHDLEDAKRLVAAGVDVLAHGVRDMEVDAELVDAMKARGTWYIPTLGLNESFYIYAEGPAWMADPFFRRALSPDLARQLDDPAWRASVLEDGKTAPVNKKALTINLKNVKTLHDAGVRIGFGTDSGATPVRIPGFAEHRELKLLTEAGLTPLQAIRLATANAAELLGLKDRGVIEAGRRADLVVVQGDPSTSIDDLSRIESVWHRGKQVPGPTSAPAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA57</accession>
    <name>Q1DA57_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552321.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2245"/>
    <dbReference type="EnsemblBacteria" id="ABF91524">
        <property type="protein sequence ID" value="ABF91524"/>
        <property type="gene ID" value="MXAN_2245"/>
    </dbReference>
    <dbReference type="GeneID" id="41359633"/>
    <dbReference type="KEGG" id="mxa:MXAN_2245"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057501_0_0_7"/>
    <dbReference type="OMA" id="WPYASRS"/>
    <dbReference type="OrthoDB" id="649967at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="75"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="44946" checksum="FB9E8437D63D65EE" modified="2006-07-11" version="1">MATGFEAYRMEDPTLLANVREALLQSYFADFDAGFLKSPAGQSDIADHVDGRYNRCIDHVLPWLARYTKLGKANVVELGCGTGSSTAAFAQVASHVTGYDIHAPSVRAAQSRMKALGLRNVDTRVVEPAKLLEQLRQENPQGADIFVLYAVLEHQTPAERLETLRTGWDLLRPGGLLVVVDTPNRLVYFDAHTSLMPFFHFLPPELGWPYASRSPRENFRDSMAQASAKDAPMLLTRWGIGVSHHELELALGDIDPLLVGTGFEPEVLDMFPVTLDEEVLRLYVEKSGARVPKALTRNTLNFVLRKGDNADLIARRPSPPPVRHLVNETSNPVQAQRLHELEHRLLEQAQRIRELEEHIATPPLRHQLVDQLNGALKQTALHRQARKLVEWSVGRVKRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI5</accession>
    <name>Q1DAI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92568">
        <property type="protein sequence ID" value="ABF92568"/>
        <property type="gene ID" value="MXAN_2111"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2111"/>
    <dbReference type="HOGENOM" id="CLU_857443_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="324" mass="34241" checksum="26E72D829534213F" modified="2006-07-11" version="1">MGVHACPGRAPIRCVAGAAGLLAVLRLNTPRPGVALVPGPTSHRPWASPAARGLAPAIPTAGHRIRKASHPEGTRHGRSNGALRVIVATADKRVRGNSVSAAEDGSFEIDVSGSVAAPVHLLAMEQAHPTRRFGIKKDITFTSGQTLDGVEIVLDHAEDQPQRVNVKNLKAYGAKAYVTMDFYFGSGFLFRNEAIDTPPLQIPAMPLTPPFDLIQLHTMVLVGSEGEFGLTSASATVHTEGGSTPEVTMPPPLQLTSVPLGTMEVPAVAPLEGFSLSWNVDPAAQVVRGHLRHKGRDPSLHWSVTAPSSITSFTPFELPVDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK0</accession>
    <name>Q1DAK0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552178.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2095"/>
    <dbReference type="EnsemblBacteria" id="ABF91776">
        <property type="protein sequence ID" value="ABF91776"/>
        <property type="gene ID" value="MXAN_2095"/>
    </dbReference>
    <dbReference type="GeneID" id="41359501"/>
    <dbReference type="KEGG" id="mxa:MXAN_2095"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643769_0_0_7"/>
    <dbReference type="OMA" id="RWWERAR"/>
    <dbReference type="OrthoDB" id="1684783at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011959">
        <property type="entry name" value="CHP02270"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02270">
        <property type="entry name" value="TIGR02270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="46471" checksum="A6501E64B627A497" modified="2006-07-11" version="1">MMLDVLEEHLSEAAFFWSQWERALVAPDYTLEETAELEERLLAHLDGLVAAGAAAIEVLSSVVYEREDPGEVFAAAWSLLALAPSLVLDAVKARATDAPPPVQASIRRALELGEKGVVETALAPLLTTAEPMAVSVLGFRGHLLGGRAEELLSHPDALVVTAALRALNLSSKSHAPRLLGVLLGDSRPEVRWAAIETGLVFGVRDAWTVCERESTAMGSPLRRRLWALLAAAGNVRFLERLISFSEAAATREDALWALGFTGQVPAAESCLRWMCEEPRVARLAGEAFSAITGLRMAGAHVLPEPEPEDALPPLEDEDLDADLGLRPEDALALPAQEEVARWWERARDGFSPANRYLRGKPFTGASLLEALAQGPMRRRHLYALELMVRTRGAYAIQVRAFTSRQREQLALASAVRERLPAWGFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB35</accession>
    <name>Q1DB35_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1893"/>
    <dbReference type="EnsemblBacteria" id="ABF86127">
        <property type="protein sequence ID" value="ABF86127"/>
        <property type="gene ID" value="MXAN_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1893"/>
    <dbReference type="eggNOG" id="ENOG5034CE8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1968156_0_0_7"/>
    <dbReference type="OMA" id="GREYREH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="16534" checksum="553881E251A73948" modified="2006-07-11" version="1">MGWRSTSWDSRRRSRPPMLCFRLLRNGRHVATAGVSGFGVVSTILTWVRRPDDETRDNPEVDLHLGGSVGREYREHLKWCYAKDIRAGDVLTVEVREDLEPDPPKERRLDEEAGLDDVARLQLRKKALEAQLADVNEELAERGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB44</accession>
    <name>Q1DB44_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551985.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1883"/>
    <dbReference type="EnsemblBacteria" id="ABF88314">
        <property type="protein sequence ID" value="ABF88314"/>
        <property type="gene ID" value="MXAN_1883"/>
    </dbReference>
    <dbReference type="GeneID" id="41359298"/>
    <dbReference type="KEGG" id="mxa:MXAN_1883"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288179_0_0_7"/>
    <dbReference type="OMA" id="LFAPRYI"/>
    <dbReference type="OrthoDB" id="83152at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117137" checksum="3A310C1B18A42B84" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB73</accession>
    <name>Q1DB73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551956.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1854"/>
    <dbReference type="EnsemblBacteria" id="ABF86279">
        <property type="protein sequence ID" value="ABF86279"/>
        <property type="gene ID" value="MXAN_1854"/>
    </dbReference>
    <dbReference type="GeneID" id="51987670"/>
    <dbReference type="KEGG" id="mxa:MXAN_1854"/>
    <dbReference type="HOGENOM" id="CLU_2181020_0_0_7"/>
    <dbReference type="OMA" id="ARGACAC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="110" mass="11331" checksum="9DA24248EB9EBCA4" modified="2006-07-11" version="1">MSVTLTNALGRLVTFLLPHESYCVARGACACGVQPGRGGRRLPSSLTLATGVSREDVHEAALSVPAVAAAIRRGELALKRQAPSTPPSSPSLLPASEASARVSRKKRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBM7</accession>
    <name>Q1DBM7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_1695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551805.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1695"/>
    <dbReference type="EnsemblBacteria" id="ABF85947">
        <property type="protein sequence ID" value="ABF85947"/>
        <property type="gene ID" value="MXAN_1695"/>
    </dbReference>
    <dbReference type="GeneID" id="41359133"/>
    <dbReference type="KEGG" id="mxa:MXAN_1695"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="ICCTIIA"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="540"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="724"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF85947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="819" mass="86353" checksum="77D93609C18673A3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBU0</accession>
    <name>Q1DBU0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1631"/>
    <dbReference type="EnsemblBacteria" id="ABF87686">
        <property type="protein sequence ID" value="ABF87686"/>
        <property type="gene ID" value="MXAN_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1631"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029526_0_0_7"/>
    <dbReference type="OMA" id="NCATYST"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="630" mass="65654" checksum="6B7A2D0FE5BE9105" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD72</accession>
    <name>Q1DD72_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551261.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1141"/>
    <dbReference type="EnsemblBacteria" id="ABF88305">
        <property type="protein sequence ID" value="ABF88305"/>
        <property type="gene ID" value="MXAN_1141"/>
    </dbReference>
    <dbReference type="GeneID" id="41358592"/>
    <dbReference type="KEGG" id="mxa:MXAN_1141"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007487_1_0_7"/>
    <dbReference type="OMA" id="RDINAFT"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="80"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="232"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="553"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="692"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="934" mass="102054" checksum="3BB6D67E3F70153D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD79</accession>
    <name>Q1DD79_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF85978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1134"/>
    <dbReference type="EnsemblBacteria" id="ABF85978">
        <property type="protein sequence ID" value="ABF85978"/>
        <property type="gene ID" value="MXAN_1134"/>
    </dbReference>
    <dbReference type="GeneID" id="41358585"/>
    <dbReference type="KEGG" id="mxa:MXAN_1134"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632867_0_0_7"/>
    <dbReference type="OMA" id="WHTWRIS"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="236"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="433" mass="47185" checksum="8EE2793071F0167E" modified="2006-07-11" version="1">MLVTMRRSDKATSHSNEDVVLATSSLQGERRVAIVRVLVVLLMAVSQVVIAWGGGETYSAPVDGVRLQAMAAYVLFSVVAIAVLLLQKPHPKRARWLPVPTTLADTSFFSFMAWHTWRISGVFDAGMLCASLGMVLAFSVVRYSWWHVLLSTVLSSGAYALLAWMTGHGSVARTSFVLICYAALGGLIALTNSEVGGMFLNLRRRDGLSRFLPRQVVERVMQLGDASLQPVQRDVTILFSDIRDFTTLSETLDPGQVLELLDDYFGHMAHIVMARHGIVNKFLGDGMLACWGVPDARENHAELAMRAALDMRAKLEDINAQRVQRGLPPLRIGIGLHTGMVAAGMLGGAEQHEYTVIGDAVNLASRVEGLTKSHGVDILVSERTWQMSGGHFTGERLGEAHVKGRRESVVVYSLHGPRTHEDVPPVLKAAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD93</accession>
    <name>Q1DD93_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551240.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1120"/>
    <dbReference type="EnsemblBacteria" id="ABF89802">
        <property type="protein sequence ID" value="ABF89802"/>
        <property type="gene ID" value="MXAN_1120"/>
    </dbReference>
    <dbReference type="GeneID" id="41358572"/>
    <dbReference type="KEGG" id="mxa:MXAN_1120"/>
    <dbReference type="HOGENOM" id="CLU_595447_0_0_7"/>
    <dbReference type="OMA" id="ERITGWM"/>
    <dbReference type="OrthoDB" id="593688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="491" mass="51343" checksum="F484246CE9C716B6" modified="2006-07-11" version="1">MRRGAWATVRARAPASPSLTAWEPGCSHGDMLSSLVLAATLATAPAPRAAASAQTLVHVPKVDALTGLAAFLERAGQHAALLRPSAWRTELHPFLAVDPTRPQSLSELGLDPAGPATVSMRKDGRVSCMRVADAKVFQAKAAEAITAAGGAEAKPTTRGGVTTVHVDRDMGGSMGYALKGKEVCAFGAIERGGADLLKESVRLVGKAPARDARLGKVPGVAFVVSGNTVVGLDGTANALQVDGVTTKLQLPVFQARGTSPYAAMNSEGLLSSRASISPMGVFQTVDTMRSTLQVLCPTCPKEQMVSMAKAVTKQLTGHMLVNMDHVQVRGSLRAMSTRFFAVRQAVAAEVTNVEAVKAALAPLGKFPDVLVLEDGWKLPLKGGNVFVRIKGKQLVLGNDESVTQATLAALTETGTKTEHPVDFALDPKRVARGLAQISLTDILADEVLAALFAASSELGPLLARSERITGWMDAAPGGAHRVSLTWPLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH7</accession>
    <name>Q1DDH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551156.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1035"/>
    <dbReference type="EnsemblBacteria" id="ABF86913">
        <property type="protein sequence ID" value="ABF86913"/>
        <property type="gene ID" value="MXAN_1035"/>
    </dbReference>
    <dbReference type="GeneID" id="41358489"/>
    <dbReference type="KEGG" id="mxa:MXAN_1035"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539482_0_0_7"/>
    <dbReference type="OMA" id="DLAFYWD"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="506" mass="54141" checksum="CAE53BEDADF0908A" modified="2006-07-11" version="1">MNATPAPEATAVEVKARALKGMFVLAARTVASQGLRVVSALFLSRLLFPSDYGLFGIVSYAASLGVFLGDLGLSAALVRQPHEPTRDETFTIFWCHQALTAVVVASVCLLAPQLTRGYALGDGAVPMVWALALGLFLSSLRVIPLMALERQLAFPVIARAELIENVVQVITTISLAALGFGAWALALGGLVRGGVGLVCIWWASPWRPQGRFRVDVLRRLLGFGLAFQLPPLVAAMVAGWVPLVVGHVLGKEAVGLVNWAWALASTPMMLSVVLNRVAFPAYCRLQDDPEGFAEYLRTSLRRLASVLLLAIPLAVLAVPVAVPLFFGTRWLPAVVLVQWFSMECILTTLVGLLATAQNAGGRPWERLAVVVCVGAAKWGLGTWAIQRFGLEGMGPAGVVVGLAEVWVTAWLVERLNPSMRGLTRQVVEPFVTLGLVLLGACLAALRLVEEGVVAQALVGAVLFAILVWARERLPGTLPLLGELRQILEFIRARRAARPTPASPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDJ0</accession>
    <name>Q1DDJ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551143.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1022"/>
    <dbReference type="EnsemblBacteria" id="ABF93020">
        <property type="protein sequence ID" value="ABF93020"/>
        <property type="gene ID" value="MXAN_1022"/>
    </dbReference>
    <dbReference type="GeneID" id="41358477"/>
    <dbReference type="KEGG" id="mxa:MXAN_1022"/>
    <dbReference type="eggNOG" id="ENOG502ZC3M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456960_0_0_7"/>
    <dbReference type="OMA" id="RSPNELC"/>
    <dbReference type="OrthoDB" id="1313849at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="564" mass="60729" checksum="B038DB1628A5F19A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDJ6</accession>
    <name>Q1DDJ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551137.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1016"/>
    <dbReference type="EnsemblBacteria" id="ABF89818">
        <property type="protein sequence ID" value="ABF89818"/>
        <property type="gene ID" value="MXAN_1016"/>
    </dbReference>
    <dbReference type="GeneID" id="41358471"/>
    <dbReference type="KEGG" id="mxa:MXAN_1016"/>
    <dbReference type="eggNOG" id="COG2863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_6_3_7"/>
    <dbReference type="OMA" id="KYVKGGL"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="11496" checksum="1797AFAFA3059B23" modified="2006-07-11" version="1">MMKRLVLSLGGATGAHADAVADVWKAKCTVCHGGDGKAQTKMGQKESIGDMSRPAWQQSRTDADIRKVIADGDPRNSKMKPFKDKLTPAQIDALVGYIRTMKAPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP3</accession>
    <name>Q1DDP3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cys/Met metabolism PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0969"/>
    <dbReference type="EnsemblBacteria" id="ABF92977">
        <property type="protein sequence ID" value="ABF92977"/>
        <property type="gene ID" value="MXAN_0969"/>
    </dbReference>
    <dbReference type="GeneID" id="41358427"/>
    <dbReference type="KEGG" id="mxa:MXAN_0969"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_7"/>
    <dbReference type="OMA" id="EVTWTDP"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="376" mass="40285" checksum="0583E35101116D23" modified="2006-07-11" version="1">MTSSPTWPRRFATRLLHTGHEQDPTTGAAAVPIYQVSMFDQPGLETPGEFDYARSGNPTRKALEGVLAALDEGHAAFAFGSGMAAVSSVLMLFSAGDHVVVTDDCYGGTYRVLTRVFSRFGLQATFVDTSDPDAVRAALRPNTRALLVESVSNPFLKRTDIPAMARVAQAHGALLIVDNTFLSPALSRPLTEGADIVIHSATKYLGGHSDVVAGAVVVKTPALAQELGFLQNAVGAVLGPQDCFLLQRGIKTLQVRLERQVRTAGALAKWLTERPEVRRVFYPGTGAVVSFRLAQDTLAAPFVESLQLPLLGVSLGAVESIVTVPARHSHASVPVAERERRGITDGLIRFSVGLEDLEDLQEDFVRAFTQADRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY7</accession>
    <name>Q1DDY7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550996.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0875"/>
    <dbReference type="EnsemblBacteria" id="ABF86964">
        <property type="protein sequence ID" value="ABF86964"/>
        <property type="gene ID" value="MXAN_0875"/>
    </dbReference>
    <dbReference type="GeneID" id="41358334"/>
    <dbReference type="KEGG" id="mxa:MXAN_0875"/>
    <dbReference type="eggNOG" id="ENOG5032QYB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530911_0_0_7"/>
    <dbReference type="OMA" id="HDWKERI"/>
    <dbReference type="OrthoDB" id="1598741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="20745" checksum="228AAD472A0E785F" modified="2006-07-11" version="1">MALAVCGLPTVASSPRRPPKGLLVMSSSLLPRLSMWAACCTLGLLGACTSVNTAPAAASLSVRELNIVDEHGQARIRIAAPMPDPKGLKRAVKAYGIQFMNASGQEVGGLGMLDSIGINALCFDSEEGYEAMCMGLIQGKPNITFRHDWKERIVIGVEEGVASIVLHDAKGTPHLKLAVDKDGATRVEEVKPAPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE57</accession>
    <name>Q1DE57_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF92293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0803"/>
    <dbReference type="EnsemblBacteria" id="ABF92293">
        <property type="protein sequence ID" value="ABF92293"/>
        <property type="gene ID" value="MXAN_0803"/>
    </dbReference>
    <dbReference type="GeneID" id="62611620"/>
    <dbReference type="KEGG" id="mxa:MXAN_0803"/>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139202_1_0_7"/>
    <dbReference type="OMA" id="EIDGCIG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="12987" checksum="9F6815936938E27A" modified="2006-07-11" version="1">MANVKQSLEETLKIEGAFAACLADSKSGMCLGSVGGSPAFNIETAAAANTEVVRAKTKAMSMLGIKDRIEDILITLGEQYHLIRPLTGKEGLFLYVALHRASANLAMARYKLSEVEKSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DER3</accession>
    <name>Q1DER3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86563">
        <property type="protein sequence ID" value="ABF86563"/>
        <property type="gene ID" value="MXAN_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0591"/>
    <dbReference type="HOGENOM" id="CLU_1702358_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17387" checksum="AF28E371F06A0615" modified="2006-07-11" version="1">MSWMPTVYTVPFGSQVCAATDWQLPLTHTAFARQNWLFPDETQHASPTSPQLRQRSPADSMTHVNVPLQDVVPALTQQAPPSLPHGSHVPLRQTSPALQLAESVLQAQPLVPYWLGEHDDELLWQPPQPARRAMNTIISPRRRGRFDFTRKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DES0</accession>
    <name>Q1DES0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0585"/>
    <dbReference type="EnsemblBacteria" id="ABF86815">
        <property type="protein sequence ID" value="ABF86815"/>
        <property type="gene ID" value="MXAN_0585"/>
    </dbReference>
    <dbReference type="GeneID" id="41358064"/>
    <dbReference type="KEGG" id="mxa:MXAN_0585"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002018_1_0_7"/>
    <dbReference type="OMA" id="YAYYADW"/>
    <dbReference type="OrthoDB" id="231654at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188223" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_N_2" evidence="3">
        <location>
            <begin position="668"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="4">
        <location>
            <begin position="881"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1572" mass="168606" checksum="B743FCE461089992" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF08</accession>
    <name>Q1DF08_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91663">
        <property type="protein sequence ID" value="ABF91663"/>
        <property type="gene ID" value="MXAN_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0495"/>
    <dbReference type="HOGENOM" id="CLU_2845235_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="65" mass="7358" checksum="199F50DA1B4FB3FD" modified="2006-07-11" version="1">MNQNVLPRPGALTTATLPRANPARVFATWSDVETKAQWFIGPHERWTPVKRERPSSRCAGGERWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF36</accession>
    <name>Q1DF36_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.262</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxA</name>
        <name evidence="4" type="ORF">MXAN_0467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.262" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550600.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0467"/>
    <dbReference type="EnsemblBacteria" id="ABF91756">
        <property type="protein sequence ID" value="ABF91756"/>
        <property type="gene ID" value="MXAN_0467"/>
    </dbReference>
    <dbReference type="GeneID" id="41357960"/>
    <dbReference type="KEGG" id="mxa:MXAN_0467"/>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040168_0_0_7"/>
    <dbReference type="OMA" id="TAQVVMM"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="346" mass="36271" checksum="B5BD653733351278" modified="2006-07-11" version="1">MGLPHVGISLGDVSGIGPEVTAAALTKPSVRKVLVPVIFGDGPTLARFPAFRRYARVEPSALGRVEGPTVVEVTRLAEKDRVPGEPSREGGRAQYAFVTAAIDAMRAGHVDALCTAPVSKEQISRAGIPFMGHTEVLAEAFGVDVMMLMDGPRVRVALATNHVPLADLPRLLTVDGLTAQLKLLSRSLEPVVGHKPRIAVLGLNPHAGEGGLLGREEVEVIGPAIRKARAARVDANGPIPADGLFAKPDEVGARYDAVLAMYHDQGLIPAKALDFERTVNVTLGLPVPRTSPDHGTAYAIAGKGEASCVPMVEALLKAAQLAGARLAHQATGRRARPGPLRPSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS2</accession>
    <name>Q1DFS2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="TCDB" id="1.B.61.1.6">
        <property type="family name" value="the delta-proteobacterial porin (delta-porin) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86577">
        <property type="protein sequence ID" value="ABF86577"/>
        <property type="gene ID" value="MXAN_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0219"/>
    <dbReference type="eggNOG" id="ENOG502ZBGT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448939_0_0_7"/>
    <dbReference type="OMA" id="DISNQGY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="608" mass="66397" checksum="995E812486524273" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT4</accession>
    <name>Q1DFT4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550353.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0207"/>
    <dbReference type="EnsemblBacteria" id="ABF90834">
        <property type="protein sequence ID" value="ABF90834"/>
        <property type="gene ID" value="MXAN_0207"/>
    </dbReference>
    <dbReference type="GeneID" id="41357710"/>
    <dbReference type="KEGG" id="mxa:MXAN_0207"/>
    <dbReference type="HOGENOM" id="CLU_153840_0_0_7"/>
    <dbReference type="OMA" id="VTVMPRE"/>
    <dbReference type="OrthoDB" id="1654414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="17340" checksum="83D9FE16269B8B08" modified="2006-07-11" version="1">MNPGSAPWERRTRERMRAMSRKNGEWGDVRVGGVPGLSARVRPLPGAAGADTQPDWIDVTVMPREEPAAASRRRTSPRPPVRSRAEVHQAGLAESAQFHQSLMRWLEAHHLLGAVRSVSEPGSMPMLHLRCAPRVLDQLRRAPEFEAGTMMPLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA1</accession>
    <name>Q1DGA1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550188.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0039"/>
    <dbReference type="EnsemblBacteria" id="ABF92651">
        <property type="protein sequence ID" value="ABF92651"/>
        <property type="gene ID" value="MXAN_0039"/>
    </dbReference>
    <dbReference type="GeneID" id="41357548"/>
    <dbReference type="KEGG" id="mxa:MXAN_0039"/>
    <dbReference type="eggNOG" id="ENOG50323ZT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486684_0_0_7"/>
    <dbReference type="OMA" id="QWATEEA"/>
    <dbReference type="OrthoDB" id="1681701at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="22561" checksum="762850FD22C15614" modified="2006-07-11" version="1">MHARNRCPPGPPGSMRRGVSEPQSSYSNGEPRRSRTTAIAAAACVLLALPFLVLGPYLLNAQARVELRCQPGGVCLLFHSSWLTRDEVASFAMKDVQGVKVDRTRAARRNRVPIFRPTLVTVHGEYPLFFQWATEEAEATRVKAQLEAAFANPGGKTVEFVRDDRNASLRVGGAFSGVGMLLLVFATWLGLRTRTHLRTEGASRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA6</accession>
    <name>Q1DGA6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, haloacid dehalogenase-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550183.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0034"/>
    <dbReference type="EnsemblBacteria" id="ABF89271">
        <property type="protein sequence ID" value="ABF89271"/>
        <property type="gene ID" value="MXAN_0034"/>
    </dbReference>
    <dbReference type="GeneID" id="41357543"/>
    <dbReference type="KEGG" id="mxa:MXAN_0034"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080587_0_0_7"/>
    <dbReference type="OMA" id="GTLWSGD"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28109" checksum="091AA888FCC2039B" modified="2006-07-11" version="1">MKMERVEETLERIRLEAERAPGGVLAFDGDGTLWSGDVGDDLFLALLEHGDIRPEAHAALERLATAHGFEKSLPARELAHQLFAAFEAGRIPEKDIYEMVAWLFAGWRVDAVRAFAKDVVARHAVKQRIHPESRRVVEWARGQGIPCYVVSASPLAVVEAAVHEVGLDPLNVLACTPRTEDGTVLAGIIEPIPYAAGKVHCLRSRTSQPLYAAFGDNVFDLELLAASRVPVAIRPKPRLRARAAELPSLVQLHPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA8</accession>
    <name>Q1DGA8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550181.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0032"/>
    <dbReference type="EnsemblBacteria" id="ABF86291">
        <property type="protein sequence ID" value="ABF86291"/>
        <property type="gene ID" value="MXAN_0032"/>
    </dbReference>
    <dbReference type="GeneID" id="41357541"/>
    <dbReference type="KEGG" id="mxa:MXAN_0032"/>
    <dbReference type="eggNOG" id="ENOG502ZDGW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1388926_0_0_7"/>
    <dbReference type="OMA" id="GTSDDHW"/>
    <dbReference type="OrthoDB" id="1632836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="22351" checksum="6B1AEB90E5A8E4DD" modified="2006-07-11" version="1">MSQGGLVKKRQDTLSDAEKRRISKRIDALFSAQQWSELDQLISESLQGTSDDHWLHVRQADAWYEQRKYSKASRLYLKVLESVPRCPLGRWGLANALMARGNADDARKLFLSLARQKPEVMGTRECGEGVRWARGLIADANFRLGQLEERAGARAAARRRYQVYLRILQRPALSLESRREANTRLRALSLKGRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-01-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O30384</accession>
    <name>O30384_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PilG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative efflux ABC transporter accessory factor PilG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pilG</name>
        <name evidence="2" type="ORF">MXAN_5782</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="1249" last="1261">
            <title>The pilH gene encodes an ABC transporter homologue required for type IV pilus biogenesis and social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Wu J."/>
                <person name="Cheng Y.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9767592"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01013.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="24" last="33">
            <title>The Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pilus biogenesis, social motility, and development.</title>
            <authorList>
                <person name="Wall D."/>
                <person name="Kolenbrander P.E."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9864308"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>New pil genes required for pilus assembly, S-motility, and Tgl stimulation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DQ242507">
        <property type="protein sequence ID" value="AAC36154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555733.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5782"/>
    <dbReference type="EnsemblBacteria" id="ABF91768">
        <property type="protein sequence ID" value="ABF91768"/>
        <property type="gene ID" value="MXAN_5782"/>
    </dbReference>
    <dbReference type="GeneID" id="41363025"/>
    <dbReference type="KEGG" id="mxa:MXAN_5782"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908588_0_0_7"/>
    <dbReference type="OMA" id="LDPYNMD"/>
    <dbReference type="OrthoDB" id="1918722at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC36154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="37801" checksum="4BF478170E23EA93" modified="1998-01-01" version="1">MSSGGSTVLRAALPQEGGLSQFYNPRELMRSVVLCLAVCAIAVMAEKPAKPLRTKDGPILPRREFLEIVGAAQKPLLADFYWLQSIQQVGRANTDTEYRDVFFYADLATDLDPKFRYVYEWGAITTPVNLGRDEWANTDLSSRLLSKGLVEFPDDRRFLFQLAYNKMTYDRDYKTAADQLMKLSKYPETPPYLLQLATRLYAQAGSIDMGLQLAQMLRDGAEDDESRAFYEHRIKELLRERLLTQIDEAVAAYQRDRGERPKAVPVLVRAGYLRAMPIDPLEGQFFIDRQGRARSTSGIYRLEMFDQKKKDELREDIAAGGIQFDLPEEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH1</accession>
    <name>Q1CVH1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7499"/>
    <dbReference type="EnsemblBacteria" id="ABF88872">
        <property type="protein sequence ID" value="ABF88872"/>
        <property type="gene ID" value="MXAN_7499"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7499"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917737_0_0_7"/>
    <dbReference type="OMA" id="SRELRYH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0883">Thioether bond</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="2">
        <location>
            <begin position="191"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32537" checksum="B19B16C2B7182072" modified="2006-07-11" version="1">MSPSRFFISSPLTPSPPGRQPPGAARVREGHNVFYASIRRGASRRATDASVAAPPARRGPSPAPLAEAGVWYSMVDLPSSALRRIEPSSARQAGKHRVGALPSFTSMNAMCLGEWVELLREKAGGVPGLGGVGEGLAGLVLEPASLQPYLHFRRGRYTRNLIYRDARLEVLLNCWDAGTFSPIHDHDGQECWFSVQSGAFVLENYTLEAGGLGPGPARLGPPVMVGPMGAGFVDFRCPEAPIHRVTATGGPAVSLHVYAGPVDRCLVFDTRRQRCVSRELRYHSVFGRPLAQLPEAPTPSAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVK2</accession>
    <name>Q1CVK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557374.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87193">
        <property type="protein sequence ID" value="ABF87193"/>
        <property type="gene ID" value="MXAN_7467"/>
    </dbReference>
    <dbReference type="GeneID" id="41364613"/>
    <dbReference type="KEGG" id="mxa:MXAN_7467"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_0_7"/>
    <dbReference type="OMA" id="GMASEVY"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="14017" checksum="FA0C3D9CB3296C8D" modified="2006-07-11" version="1">MDTELASMLGAASRAARVRMGLTQADVAERIGMASEVYGRLERGHMLPSVQNLRRLCMVLNVPPHELLGLGEGFTAPPPVKEKAAAKNREEDTPEMRRLMRNLRKLTAVQLKLMNLIASAMQHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW00</accession>
    <name>Q1CW00_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557229.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7310"/>
    <dbReference type="EnsemblBacteria" id="ABF90720">
        <property type="protein sequence ID" value="ABF90720"/>
        <property type="gene ID" value="MXAN_7310"/>
    </dbReference>
    <dbReference type="GeneID" id="41364473"/>
    <dbReference type="KEGG" id="mxa:MXAN_7310"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_2_7"/>
    <dbReference type="OMA" id="KFGMSLC"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="29257" checksum="AB107966B52ACE8D" modified="2006-07-11" version="1">MSNLQGKTLFITGASRGIGKAIALRAARDGANIIIAAKTTEPHPKLPGTIYTAAEEIEKAGGKALPCVVDIRDEQQIAAAVAKAVETFGGIDILVNNASAISLTGTLETPMKRFDLMHGINTRGTFACSQACIPYLKKASNPHILNNSPPLNMEARWFAPHVAYTMAKFGMSMCVLGMAEELRSDGIAVNAIWPRTVIATAAVQNLLGGEETIRGCRTPEIMADAAYAILTKPSREFTGNFCIDEEVLRGVGVTDFDKYQLVPGAELLPDYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW61</accession>
    <name>Q1CW61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNF2 domain/helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557168.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7249"/>
    <dbReference type="EnsemblBacteria" id="ABF85973">
        <property type="protein sequence ID" value="ABF85973"/>
        <property type="gene ID" value="MXAN_7249"/>
    </dbReference>
    <dbReference type="GeneID" id="41364415"/>
    <dbReference type="KEGG" id="mxa:MXAN_7249"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300873_0_0_7"/>
    <dbReference type="OMA" id="VIHYGRW"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="519"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="813"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="994" mass="110372" checksum="3F56D82700AF9EF2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWE8</accession>
    <name>Q1CWE8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557081.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7162"/>
    <dbReference type="EnsemblBacteria" id="ABF87883">
        <property type="protein sequence ID" value="ABF87883"/>
        <property type="gene ID" value="MXAN_7162"/>
    </dbReference>
    <dbReference type="GeneID" id="41364336"/>
    <dbReference type="KEGG" id="mxa:MXAN_7162"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009368_0_0_7"/>
    <dbReference type="OMA" id="DAHLDTC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="81"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="992" mass="107732" checksum="90A399C676EE0EB5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR7</accession>
    <name>Q1CWR7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7043"/>
    <dbReference type="EnsemblBacteria" id="ABF93080">
        <property type="protein sequence ID" value="ABF93080"/>
        <property type="gene ID" value="MXAN_7043"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7043"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_7"/>
    <dbReference type="OMA" id="HIELYQM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="38217" checksum="E8EB851249CF632A" modified="2006-07-11" version="1">MGMEYRQLGGSGFKVPVLTLGTGTFGGQGDFFKVWGSSGVEEATRLVDISLEAGLNMFDSADNYSRGLAEEILGKAISGRREKVILSTKGTFRSGEGPNDVGSSRFHITRAVEASLKRLGTDYIDLYQLHAFDALTPVEEALRALDDLVRAGKIRYIGASNFSGWHLMKSLATSEKYGLARHVAHQAYYSLVSREFEWELMPLALDQKVGTVVWSPLGWARLTGKIRRGQPRPEGSRMQSSLNAQGAPPLSEEYLFRVVDALDAVAAETGKTVPQVAINWLLQRPSVSTIVIGARNEEQLRQNLGAVGWNLTPDQVARLDAASAVTPTYPYWHQLGFAERNPFPTKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWX5</accession>
    <name>Q1CWX5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556904.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6984"/>
    <dbReference type="EnsemblBacteria" id="ABF87319">
        <property type="protein sequence ID" value="ABF87319"/>
        <property type="gene ID" value="MXAN_6984"/>
    </dbReference>
    <dbReference type="GeneID" id="41364161"/>
    <dbReference type="KEGG" id="mxa:MXAN_6984"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081766_0_1_7"/>
    <dbReference type="OMA" id="GFTPERW"/>
    <dbReference type="OrthoDB" id="1832083at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="32216" checksum="58E1BEE503F28984" modified="2006-07-11" version="1">MASKRVPTVTEIGPGTSALHAAFCDYVSRVFTRADFRRWTQWGEWNDDYRTFAVVDDGRVLANASVMRMRLLLEGREVTGYQLGAVGSLPSERGRGLARAVMNAALAHCGDAPVLLFANKSVLEFYPRFGFEPRRQTLFSASHVARPGETAAPQLDVAEADVRARLRMLSDEGLPVTERFGARGTAAIASWYAANGFARPLRALSDDAWVFTEVEGETLFIDDIFARAPFDLRAALPRLIDRPISSIQFGFTPERWWPGAVEAGEDMEADLFVRGVPSPREANLFPVMART</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXE6</accession>
    <name>Q1CXE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6810"/>
    <dbReference type="EnsemblBacteria" id="ABF89681">
        <property type="protein sequence ID" value="ABF89681"/>
        <property type="gene ID" value="MXAN_6810"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6810"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1249504_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNKP_ligase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="1">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="24401" checksum="5FD3014AFEF23574" modified="2006-07-11" version="1">MGAAPRLLVAAVDGLNAWGHAAGQAHAVTNVRNPWSSPRYIPASWKTSLTPWNRSLVLATEGVAHMDKDHVWHMETLARVCQADATLLVATPFRVVALEDEAAVAEGVRWWEELTARGGEGMVVKPLDFAVRGRKGLLQPAIKSRGPEYLRIIYGPEYTAPANLERLRQRGLSTKRSLALREFALGVEGLERFARGEPLRRVHECVFGVLALESEPVDPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ4</accession>
    <name>Q1CXJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase, aerobic</fullName>
            <ecNumber evidence="6">1.3.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemF</name>
        <name evidence="6" type="ORF">MXAN_6762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556687.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6762"/>
    <dbReference type="EnsemblBacteria" id="ABF93009">
        <property type="protein sequence ID" value="ABF93009"/>
        <property type="gene ID" value="MXAN_6762"/>
    </dbReference>
    <dbReference type="GeneID" id="41363952"/>
    <dbReference type="KEGG" id="mxa:MXAN_6762"/>
    <dbReference type="eggNOG" id="COG0408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_7"/>
    <dbReference type="OMA" id="HDKGTLF"/>
    <dbReference type="OrthoDB" id="1086432at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF93009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="34447" checksum="1AB99240CDA1E106" modified="2006-07-11" version="1">MKTVDVESLKERMTGFIRSLQDDICGGLERLDGSTRFREDSWTRPGGGGGRSRVLEDGAVLEKAGVNTSVVYGELEEQFAQKLQGEGRHFWAGGISLVLHPRNPHVPTVHANYRFIQQGGKAWFGGGADLTPYYLYEEDAAHFHRVHQAACDKHDAGYYPRFKSACDKYFYLRHREETRGVGGIFFENMGGELEKEFAFVQDCGRAFLDAYLPIAERRKDTPATEGQRFWQEVRRGRYVEFNLVYDRGTVFGLETRGRTESILMSLPPQVRWRYDYHPEPGTPEARLVEVLRQPRDWARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL2</accession>
    <name>Q1CXL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556669.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6744"/>
    <dbReference type="EnsemblBacteria" id="ABF90654">
        <property type="protein sequence ID" value="ABF90654"/>
        <property type="gene ID" value="MXAN_6744"/>
    </dbReference>
    <dbReference type="GeneID" id="41363936"/>
    <dbReference type="KEGG" id="mxa:MXAN_6744"/>
    <dbReference type="eggNOG" id="COG3358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093051_0_0_7"/>
    <dbReference type="OMA" id="NLPCAYT"/>
    <dbReference type="OrthoDB" id="1878942at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="32643" checksum="9BE3D30AFC54F72B" modified="2006-07-11" version="1">MTPIALALSLALQASPAPQNMSQTTAPTTDDLQTSTRAWHEQRIQRLQAEDGWLTLVGLFWLNEGEQTAGSAPESDLDFPAGTPPKLGTFTRQGNTARFQPAPGVTFTRNGQPFTGGALQSDEQGTPDVLKLGNVSFQLILRGDKLGVRVRDSGAAARKQFQGIPTYPASNDWRIEARFEPAQTPRMLQVPNVLGTIDEMKAPGTLVFTVAGKEHRLTPVEDGSGKLFIIFADETNRDATYGAGRFLSADMPTDGRVVLDFNRAYNPPCAFTKFATCPLPPRGNRLATRVEAGEKRYADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM4</accession>
    <name>Q1CXM4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556657.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6732"/>
    <dbReference type="EnsemblBacteria" id="ABF87451">
        <property type="protein sequence ID" value="ABF87451"/>
        <property type="gene ID" value="MXAN_6732"/>
    </dbReference>
    <dbReference type="GeneID" id="41363924"/>
    <dbReference type="KEGG" id="mxa:MXAN_6732"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_7"/>
    <dbReference type="OMA" id="GREAHDW"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="33"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="28547" checksum="7EA31153F1E95787" modified="2006-07-11" version="1">MSKTFTQTKEELVGKAKKQMDTTFGQGDWTVRQKLALTCRILFEGGHDSGLAGQITARATEPGTYYTQQLGLGFDEITASNLLVVNSDLEVLEGKGMANPANRFHSWVYEARPDVNCIIHTHPTHIVALSMLEVPLQVSHMDMCPLFDDCAFLKDWPGVPVGNEEGELISKALGSKRALLLSHHGQLVAGDSIEQACVLAELFERAARLQLLASAAGDIKPIPEKLGKEAHDWILRPTRSAITFAYFARRVLKKHGDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY14</accession>
    <name>Q1CY14_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Competence protein comEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556517.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6588"/>
    <dbReference type="EnsemblBacteria" id="ABF86118">
        <property type="protein sequence ID" value="ABF86118"/>
        <property type="gene ID" value="MXAN_6588"/>
    </dbReference>
    <dbReference type="GeneID" id="41363791"/>
    <dbReference type="KEGG" id="mxa:MXAN_6588"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_3_0_7"/>
    <dbReference type="OMA" id="MIPRWRA"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187893" evidence="2">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="12570" checksum="9E22783150A91F42" modified="2006-07-11" version="1">MRALCAVVVGLLLCGPGVAEAAKLRTQHTGTVNLNEASAAELDLLPGVGEKAAQRIIEHRQKRPFKRVEELVRVKGFGKKKFLKLKAHLALSGPTTLRVEQVPAPPERKEVSATND</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYR7</accession>
    <name>Q1CYR7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556264.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6331"/>
    <dbReference type="EnsemblBacteria" id="ABF87172">
        <property type="protein sequence ID" value="ABF87172"/>
        <property type="gene ID" value="MXAN_6331"/>
    </dbReference>
    <dbReference type="GeneID" id="41363546"/>
    <dbReference type="KEGG" id="mxa:MXAN_6331"/>
    <dbReference type="eggNOG" id="ENOG502ZZV4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077132_0_0_7"/>
    <dbReference type="OMA" id="VDASHRW"/>
    <dbReference type="OrthoDB" id="1664282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26664" checksum="F8551BA0A61A999B" modified="2006-07-11" version="1">MTRFFWLREDSTVQAHTNGSLNAAHKWGLPGLAGCPGCGETWASSGHQYPAVDLSVLPEQSAFLKARPEPFTEFSRLRELVRPLAPPGALLPPGTTFGPLVGTASGRFGSFAWLGSSLLLIRHEELERLREEGIRGLLGARTELRFRQKDAPELLELQLDPRGQLHADCMPPDLPPRCATCGRLGFRRPDEPILDAASLPVDVDLFRVGNFATMIVGTERFMETVRRLELDGVSFRELPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ22</accession>
    <name>Q1CZ22_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ileS</name>
        <name evidence="11" type="ORF">MXAN_6220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556164.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6220"/>
    <dbReference type="EnsemblBacteria" id="ABF90022">
        <property type="protein sequence ID" value="ABF90022"/>
        <property type="gene ID" value="MXAN_6220"/>
    </dbReference>
    <dbReference type="GeneID" id="41363447"/>
    <dbReference type="KEGG" id="mxa:MXAN_6220"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_7"/>
    <dbReference type="OMA" id="KMMAPFT"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="876"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="661"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1247" mass="140232" checksum="6E98F668283DD36D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA8</accession>
    <name>Q1CZA8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88101">
        <property type="protein sequence ID" value="ABF88101"/>
        <property type="gene ID" value="MXAN_6132"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6132"/>
    <dbReference type="eggNOG" id="ENOG502Z9XA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052329_0_0_7"/>
    <dbReference type="OMA" id="RWEGEGW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188066" evidence="2">
        <location>
            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="48717" checksum="071637DC0780F909" modified="2006-07-11" version="1">MRFLRRMRLAQVAVAAIGISSFGSAVADPEVKTVPDVLEVGALTSTFAEFQRTCDAAGRRLWGQSLCAPLLVVHPVTRVFVASTWPSGSGTGPWVGVFPSELTIANTALTWAGTTWVQLQAPLPDAPARRRALLAHEAFHRLRTTLGHPGREKDNAHLDGIEGRTLLQLEWRALAAALRATPPSVRTRAVEDALVFRRERRALFPEAAVAEGLLEEHEGLAEYTGVTLAVADARGRRALALENLDDAVKRSSFVRSFAYASGPAYGLLLDEAGPRAQGWRARALAGADLGTLLQDALRLGMPEPSPEREARYGGAALRETERERARLTQARAEALRKKLVEGPVLHLPLVRMRIQFNPGELIPLAEHGTVYPGARIVDAWGSLTATSDVLLSSDWKTATVNAPPSGPRDARWEGEGWVLELAPGWRANKGPRPGDLVLQAPEARSPAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB5</accession>
    <name>Q1CZB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556072.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6123"/>
    <dbReference type="EnsemblBacteria" id="ABF88728">
        <property type="protein sequence ID" value="ABF88728"/>
        <property type="gene ID" value="MXAN_6123"/>
    </dbReference>
    <dbReference type="GeneID" id="41363357"/>
    <dbReference type="KEGG" id="mxa:MXAN_6123"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2047160_0_0_7"/>
    <dbReference type="OMA" id="YRLNFIE"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13060" checksum="69FCB640D87A5405" modified="2006-07-11" version="1">MTAAFVKLLVTDSARSVAFYEALGFTRVSAEPPFVHLRWAEALDVYLVTPPPQLKLEGRRGTGVLVGLRAEAPHSLDEVLLRAQAQGAAVDGPTVQPWYTRELIVTDPDGYRLNFIEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC8</accession>
    <name>Q1CZC8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556059.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6110"/>
    <dbReference type="EnsemblBacteria" id="ABF89560">
        <property type="protein sequence ID" value="ABF89560"/>
        <property type="gene ID" value="MXAN_6110"/>
    </dbReference>
    <dbReference type="GeneID" id="41363345"/>
    <dbReference type="KEGG" id="mxa:MXAN_6110"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_2_0_7"/>
    <dbReference type="OMA" id="LFGAAHW"/>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="20045" checksum="55746F1E2CE08E63" modified="2006-07-11" version="1">MTVGVVLLAAGGSSRLGHPKQLVRYQGSTLVRRAAEAAASLRCGPVVVVLGASRDAVAAELTGLPVRTVDHADWAAGPGGSLRAGLGALRETEPPALNAVLVLLCDQLRVDAAHLRTLLDTFERTRASVVASAYEDTRGVPALFARDVFPELDALSPGQGARGVIARVASRVVDVPLPGGGDDVDTPEDVSRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZU9</accession>
    <name>Q1CZU9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkylated DNA repair protein AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alkB</name>
        <name evidence="7" type="ORF">MXAN_5937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5937"/>
    <dbReference type="EnsemblBacteria" id="ABF92660">
        <property type="protein sequence ID" value="ABF92660"/>
        <property type="gene ID" value="MXAN_5937"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5937"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039677_1_1_7"/>
    <dbReference type="OMA" id="NCGPLGW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="115"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="23288" checksum="6BC60AF5CA973613" modified="2006-07-11" version="1">MDLFDGLGGTGPREESLGPGAVVLRGFALSHDAELLSAVQDVALASPFRHMETPGGFRMSVAMTSCGSWGWVTDRTGYRYAAVDPVQGRPWPEMPAIFLRLAQFAAAKAGFEGFIPDACLVNRYEPGAKMSLHQDKDERDFTAPIVSVSLGLPAVFLFGGAERADRPARVRLSHGDVVVWGGPARLRYHGVTPLEPGHHPQVGGHRINLTFRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZX0</accession>
    <name>Q1CZX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5916"/>
    <dbReference type="EnsemblBacteria" id="ABF87209">
        <property type="protein sequence ID" value="ABF87209"/>
        <property type="gene ID" value="MXAN_5916"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5916"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_7"/>
    <dbReference type="OMA" id="TFLAVQY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="67"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="202"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="36906" checksum="20899AD5536C0A24" modified="2006-07-11" version="1">MRRRRLRGRPGCVKKPAAVAAVTSPGEPGVILSGGPRDMSTSTSDMLGGGTEPSSRSQRLRADGALALITSFWGITFVVVKDALGHGDPFSFLTLRFIVGAVVLSVLAGRQVLIARNLRIGSMLGTFLFLGFSLQTVGLTTTTPSRSAFITGLCVLLVPLLSMVLYRKAPKFTSLLGVGVAAVGLYFFTQPDGGLGSGGLSSGDVLSLGGAVAYACHILMTERHAPKQGVMGLVAVQLWTVALLSALCLPFVERRVAWHPSFVGAVLVCGVFASAVAISLQTWGQARTTAVRAALIYSLESVFAALYSVLLGYETLGPREWLGGALILSGVLMSEVGAAAWVWWRARAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D043</accession>
    <name>Q1D043_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555794.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5843"/>
    <dbReference type="EnsemblBacteria" id="ABF92336">
        <property type="protein sequence ID" value="ABF92336"/>
        <property type="gene ID" value="MXAN_5843"/>
    </dbReference>
    <dbReference type="GeneID" id="41363081"/>
    <dbReference type="KEGG" id="mxa:MXAN_5843"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OMA" id="TFHFRYR"/>
    <dbReference type="OrthoDB" id="1412466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="27531" checksum="F17C63358C38DD86" modified="2006-07-11" version="1">MGQRQYSGWPMGLECRGWLLLSGLVSLLLVGCASTAPGLASLSEPPSSLECARSDEGACVVLACESGTCGLFDCEDVAQEEEAQAAFRPVLAGAFRPPTRGVPSFRHWRNLGIRSGSRPRMTFHFRYREGFLPALPRGPGKLVHHHLFPQQPELARWFRSHGVDIHKFTILIPEHIHRQLHSGKGRGGMWNQAWRDFRDSQQGRSMTSEELHRKAVELIFRFELTGPVVPYNAPVAPYQAAPSIRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q4</accession>
    <name>Q1D0Q4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555584.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5630"/>
    <dbReference type="EnsemblBacteria" id="ABF86232">
        <property type="protein sequence ID" value="ABF86232"/>
        <property type="gene ID" value="MXAN_5630"/>
    </dbReference>
    <dbReference type="GeneID" id="41362876"/>
    <dbReference type="KEGG" id="mxa:MXAN_5630"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_7"/>
    <dbReference type="OMA" id="GFAFCDV"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="110"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="449" mass="50088" checksum="6F13441E667DDAAB" modified="2006-07-11" version="1">MDTLRRWLDEKGVQKVKVGAVDVDGVWRGKYISLEKFLSAAKGGLGFCDVVFGWDLSDDLLDNTQVTGWHTGYPDAHAKVDPSTGRVIPWEPDTAAFLLDFENPDGTPFEASPRQLLQKVAARARSLGYLPRFGAEYEFFIFKEQPQSLRDKDFQGLTPLTPGMFGYSWLRTSLNAPLVHALIDGCNAFGLGIEGFHTETGPGVFEAAIRYDDIEKSADKAALFKTVVKEICARHGVTACFMAKVDAKLPGCSGHVHQSLWDLDGEQNLFHDAKAPHGMSKLLRHYIGGQVALMPELTALYWPTINSYKRSVENTWAPTTVTWGLENRTTAIRVIGESAKAMRLEYRQLGADMNAYIGMAVSLAAGLWGIENEVEPPAPCESNAYAKNDAPPLPRNLKDAVALLKGSERARELLGYGFVDHFVRTREWEVRQYERAVTNWELERYLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D148</accession>
    <name>Q1D148_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555440.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5482"/>
    <dbReference type="EnsemblBacteria" id="ABF90660">
        <property type="protein sequence ID" value="ABF90660"/>
        <property type="gene ID" value="MXAN_5482"/>
    </dbReference>
    <dbReference type="GeneID" id="41362737"/>
    <dbReference type="KEGG" id="mxa:MXAN_5482"/>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010312_4_0_7"/>
    <dbReference type="OMA" id="DPMVIDW"/>
    <dbReference type="OrthoDB" id="114076at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="232"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="253"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="706" mass="76934" checksum="74B4EA65C7BAC84F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D191</accession>
    <name>Q1D191_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5439"/>
    <dbReference type="EnsemblBacteria" id="ABF93065">
        <property type="protein sequence ID" value="ABF93065"/>
        <property type="gene ID" value="MXAN_5439"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5439"/>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942787_0_0_7"/>
    <dbReference type="OMA" id="QNEWAND"/>
    <dbReference type="OrthoDB" id="955926at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188145" evidence="1">
        <location>
            <begin position="44"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="33166" checksum="F43C81102793D1A7" modified="2006-07-11" version="1">MKFGIIGCAGASAPKQRGDAHVRIKFAHLVFVALLSASSSALAQVETRCFNDDQIINPVDAQGRNAWARKCGYIDTRREAGYNSFGDYVIFANGCHMYPNHPTGTACTFRVPLTESAPCLTFTPALLGTCVVGCYTAREELRFDDRYWPIEDAPQGGVTSVTALTQNATLLRPEFAEQPIQSYVAGDTVEDIFVLQTADGHKVEVTSEHPMVNGDGVMVRANTLKVGDTLLRVDGRKVDLTQVSVFRYTGKVWNVKPQSKVKMENVLDVEGLMTGSVRFQNEWANDYFRLTVREALDVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H4</accession>
    <name>Q1D1H4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase, 2C family</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555314.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5349"/>
    <dbReference type="EnsemblBacteria" id="ABF89531">
        <property type="protein sequence ID" value="ABF89531"/>
        <property type="gene ID" value="MXAN_5349"/>
    </dbReference>
    <dbReference type="GeneID" id="41362618"/>
    <dbReference type="KEGG" id="mxa:MXAN_5349"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_4_1_7"/>
    <dbReference type="OMA" id="EDHTWVA"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="BRENDA" id="3.1.3.16">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="265" mass="29008" checksum="5CE6535683C91877" modified="2006-07-11" version="1">MSSTAGQTAASRLKIISAGLTDVGRKRNHNEDSFLIDDELQLYVVADGMGGHAGGGTASRIAVETIDKEMRRAREGKDNPFLSVPNLQDSPIPEALRTAVERACLAIFTAAQEDARLSGMGTTVISLVVRDEHAFFAHVGDSRAYLIRGDLIQQISEDHSLVNEQIKAGMITPEEAKHSRYKNIITRSVGFEEEVQVDVMGLVSEPGDVFLLCSDGLANMMEDREIHETVVKARTFEEVPKRLIDFANERGGDDNITVIVVRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U6</accession>
    <name>Q1D1U6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate reductase, cytochrome b subunit</fullName>
            <ecNumber evidence="8">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">frdC</name>
        <name evidence="8" type="ORF">MXAN_5225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.1" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5225"/>
    <dbReference type="EnsemblBacteria" id="ABF86714">
        <property type="protein sequence ID" value="ABF86714"/>
        <property type="gene ID" value="MXAN_5225"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5225"/>
    <dbReference type="eggNOG" id="ENOG502Z7RU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077968_1_0_7"/>
    <dbReference type="OMA" id="QHGFWSA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="26143" checksum="C6643D88359687CF" modified="2006-07-11" version="1">MQSIGEFNEDRPQDASRRRHPWRSTVGLKVLMAATGIVLVVFLVFHLLGNLLVYRGRDALNEYSAFLVREPPLLWAARAVLLASAVIHIGAAALLWNRDRFARPVAYRRLRPRSTTVPARTMRLTGVVLAGFIVFHILHLTTGTIAPVPFEKHDVYHNVVEGFRVPWVVAIYLGALAFVGMHVWHGAWASLRSLGRSRPSPRPKRRPVAWILALVLWGGFSSIPLTIWLGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D209</accession>
    <name>Q1D209_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555132.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92982">
        <property type="protein sequence ID" value="ABF92982"/>
        <property type="gene ID" value="MXAN_5161"/>
    </dbReference>
    <dbReference type="GeneID" id="41362443"/>
    <dbReference type="KEGG" id="mxa:MXAN_5161"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_7"/>
    <dbReference type="OMA" id="WQLTATI"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="24959" checksum="124DCB23DF2AA1B3" modified="2006-07-11" version="1">MCGRVTVRTSPEQIVTGLGLAGIRTAVERPRFNLCPTQLMPVVTNDGARMLDAFRWGLVPSWAKDPAIGNKLINARGETVAEKPSFRSALKRRRCLVVVDGWYEWKQSTKPKTPYYFHRKDGQLLTLAGLWEEWTAPDTGEVLNTCTLITIGPNALMAPIHDRMPVILEPEAQEVWLRPEPQESSVLLPLLVPCAEEALDVYEVSRVVNSPANDTPECVERVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D274</accession>
    <name>Q1D274_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5095"/>
    <dbReference type="EnsemblBacteria" id="ABF90263">
        <property type="protein sequence ID" value="ABF90263"/>
        <property type="gene ID" value="MXAN_5095"/>
    </dbReference>
    <dbReference type="GeneID" id="41362379"/>
    <dbReference type="KEGG" id="mxa:MXAN_5095"/>
    <dbReference type="eggNOG" id="COG3488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033900_1_0_7"/>
    <dbReference type="OMA" id="CMTCHVK"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010538">
        <property type="entry name" value="DHOR"/>
    </dbReference>
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        <property type="entry name" value="DHOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028099">
        <property type="entry name" value="DUF1111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="74"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="328"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="461" mass="50037" checksum="0E50AE274976D094" modified="2006-07-11" version="1">MRRRRYLLGIPVGAIAIAAVWASTHRLPRPLELGALPATTEPGEELSGGRGSVPDPGRNAFGRAPMNMPRTRWEDFHAGKRVFGRDWTDVDGPIQVGPLFNAPSCMTCHVKDGRGQPPASPSETPISLAFQLSGPDGRGPHPIYGAQLDVRHVDGTGAEGSVEVTHEEVTGRFASGETYVLHRPRYRFTQLSKGPLGEETRFSPRVAPANFGLGLLEAIPEAAVLAHEDSEDRDQNGISGRANRVRDAATGQTRMGRFGWKANQPTLHQQVAHALVTDMGLTTELYPREQGREAGEAAPPEVSPKELDALLIYARLVAVPKRRDWEAADVLRGKAVFGAIGCAGCHVGTVFETEDVPGFPELSGQHIRPYTDLLLHDMGEGLADDRPDGLATGTEWRTPPLWGVGLVKAVNGHTRFLHDGRARDLEEAVLWHGGEAAPAQERYTRLPLADRQALLAFLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2C6</accession>
    <name>Q1D2C6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OmpA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555018.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5042"/>
    <dbReference type="EnsemblBacteria" id="ABF90356">
        <property type="protein sequence ID" value="ABF90356"/>
        <property type="gene ID" value="MXAN_5042"/>
    </dbReference>
    <dbReference type="GeneID" id="41362327"/>
    <dbReference type="KEGG" id="mxa:MXAN_5042"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020578_0_0_7"/>
    <dbReference type="OMA" id="IPENQGC"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OmpA-like" evidence="7">
        <location>
            <begin position="507"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="640" mass="68145" checksum="37CCC564EB77C777" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2G0</accession>
    <name>Q1D2G0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554984.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5008"/>
    <dbReference type="EnsemblBacteria" id="ABF90585">
        <property type="protein sequence ID" value="ABF90585"/>
        <property type="gene ID" value="MXAN_5008"/>
    </dbReference>
    <dbReference type="GeneID" id="41362292"/>
    <dbReference type="KEGG" id="mxa:MXAN_5008"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762517_0_0_7"/>
    <dbReference type="OMA" id="YFVTSWA"/>
    <dbReference type="OrthoDB" id="726982at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="362" mass="38863" checksum="935793159241BD82" modified="2006-07-11" version="1">MKGRARHAGGRALLKALLAVFGLVLSVVLLSTAFFKWNLSGTGPLLQPRFPLGDFVRDLPRHLVWLVPFMLLQASIIPLRAVQWQRTLRRHVPLKERYHLVAIGAFVHNALPGKLGDVMRSFLLSRTQRIPFLRCLGTVGVCKLMEFAALMLLVMLSLLGPFGRTLSRFEGELKVAVLLCVGLVALVVFLAHWSGPLAFALHRRHKLPRVEGFLHHVSEGLGTARSFTGMAKVFVFSVAPVLASALAYGLALHGIGISGGLFAGAVVLGAISLGQSLPGVPAGMGIYYFVTSWAARSLGASPEDAAAFATLTHLGTVISQVAVGAVSVHLRKIRIRDLRKGGSLAREAASHVAHDAVEPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2N2</accession>
    <name>Q1D2N2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4935"/>
    <dbReference type="ESTHER" id="myxxd-q1d2n2">
        <property type="family name" value="A85-Mycolyl-transferase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89705">
        <property type="protein sequence ID" value="ABF89705"/>
        <property type="gene ID" value="MXAN_4935"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4935"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026624_1_1_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="43809" checksum="4E2A89195BBBD76A" modified="2006-07-11" version="1">MTWSLQRVRCHGQIRTLASHLPLADEEPVVAPPTLRGQRMRRLLPQDVFVSSTALERCESPARAALRLVGVFFVALFLGVPGGAEASDASLAPNFYSGHGITVHAVRHITDRLIDVEISTPLIAPHAVYDPRHHVRVLLPTGYYNNPGVRYPAVYLLHGGGGANSAQWVEFGAAYAITENMPVITIMPDGGKVGWYTNWVFPRGVNQAWEEFHLNQLIPWVDQNLRTLAYKRGRAIAGLSMGGFGAISYAARRPDLFAYAASFSGALDLGDAAIRATVTEEGTRWLQNPDGAFGSPFWPFDQAWNMNNPIPRAASLRGVAVALYAGSGIWDGDVLERVPGASTDRFHHALNAAGVPHHYEMYGRPAPGQKPFGCDGGHNFSCWNYAFFDVLPRMLAVLDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2S4</accession>
    <name>Q1D2S4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4892"/>
    <dbReference type="EnsemblBacteria" id="ABF86085">
        <property type="protein sequence ID" value="ABF86085"/>
        <property type="gene ID" value="MXAN_4892"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4892"/>
    <dbReference type="HOGENOM" id="CLU_1249944_0_0_7"/>
    <dbReference type="OMA" id="ERWRYEE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="24190" checksum="13F941DF77B6E2F9" modified="2006-07-11" version="1">MGMIGRVQDHLEAIYGFTCEARAEVFVVDTEAAAQLGGTGRADEELLVHEADDALELALYLSPALLDRLKPYESGPLGYVLDSDLAGYCQLAEGVSHFLYVAHTAAHGRTVSLLELEAQAEVDKFAVCLLHRWGEGVGAWARELLQRLFDRVSYRKQLSVQERWRYEEANRLSRRFCSRLMGHVAARRLDRLLADLRYAYRLGAEAKLRHFAHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2V0</accession>
    <name>Q1D2V0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554848.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4864"/>
    <dbReference type="EnsemblBacteria" id="ABF90792">
        <property type="protein sequence ID" value="ABF90792"/>
        <property type="gene ID" value="MXAN_4864"/>
    </dbReference>
    <dbReference type="GeneID" id="41362156"/>
    <dbReference type="KEGG" id="mxa:MXAN_4864"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497658_0_0_7"/>
    <dbReference type="OMA" id="KAFHFMQ"/>
    <dbReference type="OrthoDB" id="642145at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="626" mass="66744" checksum="FBA4FD12EE1832BD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D338</accession>
    <name>RL32_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">MXAN_4773</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554760.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D338"/>
    <dbReference type="SMR" id="Q1D338"/>
    <dbReference type="STRING" id="246197.MXAN_4773"/>
    <dbReference type="EnsemblBacteria" id="ABF89150">
        <property type="protein sequence ID" value="ABF89150"/>
        <property type="gene ID" value="MXAN_4773"/>
    </dbReference>
    <dbReference type="GeneID" id="41362072"/>
    <dbReference type="KEGG" id="mxa:MXAN_4773"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_7"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000296512" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="62" mass="6972" checksum="7BF2F8ADF64CE204" modified="2006-07-11" version="1">MGVPKKRTSKMRRDRRRAANNNLRSAVQVTKCPNCKEPVMPHRACTSCGQYKGREVVAQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3C5</accession>
    <name>Q1D3C5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554673.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4682"/>
    <dbReference type="EnsemblBacteria" id="ABF85846">
        <property type="protein sequence ID" value="ABF85846"/>
        <property type="gene ID" value="MXAN_4682"/>
    </dbReference>
    <dbReference type="GeneID" id="41361981"/>
    <dbReference type="KEGG" id="mxa:MXAN_4682"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046654_0_0_7"/>
    <dbReference type="OMA" id="SSWSYPG"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="38300" checksum="5ACB088D5E1C7BD9" modified="2006-07-11" version="1">MPQERGPAQLDLFTGAAVEPPAKGRKGAQPVEPAAVPESLATLGRELPQGVFLGTSSWTFPGWSGIVYDHEASASQLAREGLAAYAHHPVLRTVGIDRTFYGPIASSAFAEYAAQVPDTFRFLVKAHEVCTLARFPLHERYGAQRGQTNERFLHAAYATEAVVMPFVEGLGEKAGPLVFQFPPQDPQALGGPARFVERLHAFFAALPKGPLYAVELRNEELLTEGLAQALADVGVSPVLAVWAHMPPVGRQAKLTRAFESRALVVRWMLPPDLGYEEARARYAPFNKLVDEDVPTRDVLARVCLAALRRDKPTFITINNKAEGSAPLSAIKLAERVVLGRREEAERHAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K2</accession>
    <name>Q1D3K2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554598.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4603"/>
    <dbReference type="EnsemblBacteria" id="ABF92818">
        <property type="protein sequence ID" value="ABF92818"/>
        <property type="gene ID" value="MXAN_4603"/>
    </dbReference>
    <dbReference type="GeneID" id="41361903"/>
    <dbReference type="KEGG" id="mxa:MXAN_4603"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463687_0_0_7"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="304"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="588" mass="67865" checksum="601A578CA209A84B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3W2</accession>
    <name>Q1D3W2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pvc16_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4492"/>
    <dbReference type="EnsemblBacteria" id="ABF92301">
        <property type="protein sequence ID" value="ABF92301"/>
        <property type="gene ID" value="MXAN_4492"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4492"/>
    <dbReference type="eggNOG" id="ENOG502ZCMP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116582_0_0_7"/>
    <dbReference type="OMA" id="DEHRIMA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17519" checksum="0A67EAE9D5FF1FBE" modified="2006-07-11" version="1">MAGSETNTPPVEVPGVTLFLYRVAVNEHLRNEPRAEAPPPLALDLHYLLTVWAENVDDEHRIMAWVMLQLHTHNALSASDLSPVGVWRPDELVQIVPAEIPQEDILRMWDALRRPYRPSVTYVARVVCIDVQGKPAGRPVVARRFDFTDEVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D413</accession>
    <name>Q1D413_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554438.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4439"/>
    <dbReference type="EnsemblBacteria" id="ABF90939">
        <property type="protein sequence ID" value="ABF90939"/>
        <property type="gene ID" value="MXAN_4439"/>
    </dbReference>
    <dbReference type="GeneID" id="41361751"/>
    <dbReference type="KEGG" id="mxa:MXAN_4439"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296102_0_0_7"/>
    <dbReference type="OMA" id="GTQWRVH"/>
    <dbReference type="OrthoDB" id="51809at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188338" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1031" mass="105797" checksum="8F2F1AB3696E008E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92910">
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        <property type="gene ID" value="MXAN_4434"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_4434"/>
    <dbReference type="eggNOG" id="COG0515">
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    <dbReference type="OrthoDB" id="270067at2"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein phosphorylation"/>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PEGA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="6"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="724" mass="73922" checksum="2AB62EEC4C3003C8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D446</accession>
    <name>Q1D446_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Peptide synthetase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_4405</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4405"/>
    <dbReference type="EnsemblBacteria" id="ABF90442">
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        <property type="gene ID" value="MXAN_4405"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_4405"/>
    <dbReference type="eggNOG" id="COG0318">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="581" mass="63491" checksum="DA4D95A0B25FCC74" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4K1</accession>
    <name>Q1D4K1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF86766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4247"/>
    <dbReference type="EnsemblBacteria" id="ABF86766">
        <property type="protein sequence ID" value="ABF86766"/>
        <property type="gene ID" value="MXAN_4247"/>
    </dbReference>
    <dbReference type="GeneID" id="41361563"/>
    <dbReference type="KEGG" id="mxa:MXAN_4247"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="EHMRSEL"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="32490" checksum="1E98DC27B435AF23" modified="2006-07-11" version="1">MRLDLADLRLFLCIVDAGSITQGAQRANLTLASASERLRSIEDAVGVKLLERRPRGVVTTEAGDALVHHARLILHQQELLKDELNAFVSGRRGTIRLYANTAALTEYLPEKLAPWLARHPRLNIDLRERTSADIVKAVEAGLAEAGLISDAVETGTLQVRPLEPAPLVLIIPAGHPLAASKSLALRDVYREPFVGLAAESALQEHIDGHARRAGFDVSFRVRMKGFRGLCEMVSHGVGLGIVPERVANRHQREGTYRKVPLSEAWAQRRLCVCFQDWDGLSSPVRALLEYLLGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D566</accession>
    <name>Q1D566_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4028"/>
    <dbReference type="EnsemblBacteria" id="ABF88900">
        <property type="protein sequence ID" value="ABF88900"/>
        <property type="gene ID" value="MXAN_4028"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4028"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404818_0_0_7"/>
    <dbReference type="OMA" id="WLVEDQV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="368"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="573" mass="60466" checksum="A2A5496038E4EDFA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K9</accession>
    <name>Q1D5K9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PapD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553894.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3884"/>
    <dbReference type="EnsemblBacteria" id="ABF90645">
        <property type="protein sequence ID" value="ABF90645"/>
        <property type="gene ID" value="MXAN_3884"/>
    </dbReference>
    <dbReference type="GeneID" id="41361217"/>
    <dbReference type="KEGG" id="mxa:MXAN_3884"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076533_2_1_7"/>
    <dbReference type="OMA" id="QVRTYRW"/>
    <dbReference type="OrthoDB" id="1105091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016147">
        <property type="entry name" value="Pili_assmbl_chaperone_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00345">
        <property type="entry name" value="PapD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="SSF49354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188249" description="PapD_N domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PapD_N" evidence="2">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="28225" checksum="7647363190B9D7D0" modified="2006-07-11" version="1">MRNRLLSWTGGLMCSAALEWMAMGTVSAAELDVSPVRLELDSSARGVVMNVRNKSSESTRFQASVYSWVQDEEGRMSLAPTQDLFFFPSMLTLEPGESRPIRVGSSSAPQDTERSFRIVVEELPPLQPSTPTTGLNVLTRISVPVFVAPKKKTVQGQIAEAVLRESKFHVRVQNPGTVNFFIRNLRVRGLDAKGKRLVEKEEPGWYVLAGDAQVYAMEIAGKVCRKVRTVEVEMETDQGVLRQTSPVESPAPCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5N6</accession>
    <name>Q1D5N6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3855"/>
    <dbReference type="EnsemblBacteria" id="ABF91097">
        <property type="protein sequence ID" value="ABF91097"/>
        <property type="gene ID" value="MXAN_3855"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3855"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078766_0_0_7"/>
    <dbReference type="OMA" id="HEATHGV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="32000" checksum="552BAD269FA091F7" modified="2006-07-11" version="1">MAACAGCLWLASHAERLAIQALAAVVFSFVNNTVFSLLHEATHGVLHPVRWVNDTLGRFAAAFFPTSFTMQRAFHLNHHRHNRTHLEQFDYFRPGDNRFLKRAQWYSILTGLYWLFVPVGAVVFALVPGLLHRLRGTGTRYGEQTGADAYLGRLEAASGGAIRAEVLLAACVQAGLVVALDVSAMGWGLCYAAFAVNWSALQYADHAWSPLHVRDGAWDLRVAAPVRWLFLNYHYHRAHHRHPHVPWLYLGRYVDPEVARPSFLRIWLSMWRGPRPLPAAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5P1</accession>
    <name>Q1D5P1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative general stress protein GsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553862.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3850"/>
    <dbReference type="EnsemblBacteria" id="ABF90101">
        <property type="protein sequence ID" value="ABF90101"/>
        <property type="gene ID" value="MXAN_3850"/>
    </dbReference>
    <dbReference type="GeneID" id="41361183"/>
    <dbReference type="KEGG" id="mxa:MXAN_3850"/>
    <dbReference type="eggNOG" id="COG3729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142865_6_1_7"/>
    <dbReference type="OMA" id="TSRNHDK"/>
    <dbReference type="OrthoDB" id="2083197at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16127" checksum="3814DB84617DDE26" modified="2006-07-11" version="1">MSDKDNKGSMTVAEAGRKGGETVRNERGREFYETIGRKGGATVKAERGRSFYEEIGRKGGETVKAERGAKFYEEIGKKGGDRVKATRGPNFYEEIGRKGGQKVKKLIEEGKRAARAAMAAQEGAAGAPPQEGAAPAPSTPPSSGEPAGPGQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5R7</accession>
    <name>Q1D5R7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gspG</name>
        <name evidence="13" type="ORF">MXAN_3824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553836.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3824"/>
    <dbReference type="EnsemblBacteria" id="ABF91941">
        <property type="protein sequence ID" value="ABF91941"/>
        <property type="gene ID" value="MXAN_3824"/>
    </dbReference>
    <dbReference type="GeneID" id="41361156"/>
    <dbReference type="KEGG" id="mxa:MXAN_3824"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_2_1_7"/>
    <dbReference type="OMA" id="VAPKYFS"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="12">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF91941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="16206" checksum="73D9237DF3173829" modified="2006-07-11" version="1">MNPTQQKLNARRRHVRGFTLIEIMVVITILGLIAAAVGVSVMSNLEEAKQKTAALDIKTLETGLKLHYMKTGSFPETQAGLEELLQARSLERLPQDPWNRDYVYMNEGGNPVILSYGADGVPGGDGSDADISSQVASPSASAARRPKGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5R8</accession>
    <name>Q1D5R8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553835.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3823"/>
    <dbReference type="EnsemblBacteria" id="ABF92203">
        <property type="protein sequence ID" value="ABF92203"/>
        <property type="gene ID" value="MXAN_3823"/>
    </dbReference>
    <dbReference type="GeneID" id="41361155"/>
    <dbReference type="KEGG" id="mxa:MXAN_3823"/>
    <dbReference type="eggNOG" id="COG4946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043792_0_0_7"/>
    <dbReference type="OMA" id="GHEPWVS"/>
    <dbReference type="OrthoDB" id="697026at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030916">
        <property type="entry name" value="ELWxxDGT_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04534">
        <property type="entry name" value="ELWxxDGT_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="491" mass="52818" checksum="52E94A934FE6C5DD" modified="2006-07-11" version="1">MKPHLPLLMLLGAAGCGTEVEDADFTSQESALSQKWELCGKEAVRLADIHPGPVGSNPADLIHGDRVLFFTADDGTHGRELWRSSGTEGSGTSLVKDIYPGLAGSEISNLTRVGNRVFFAADDGVHGYELWVTDGTSAGTYLVKDIYPGPEDGIRRPDPFYWINDPMLVEFGGVLYFGANDGVHGYELWRSDGTDAGTYLVEDIEPGPANSFPRRLVRVGNEAFYFVASKRGPWSDEIHLWRSTGVPGAIPVLSLVGDNVIFDLLAVKSRLYFLVDNDEGEASLWKTDGAASNTHELRYFYGEYPHDLVALGSRVVFSAGAGEPEGEELWSSNGSTSSTKLVKDIWPGPMSSSPSSLAVLKSRVFFAANDGSGEGRELWVSNGTGSGTRLFKALAPGGGSSDPEALASIEGTLFFSASDGVHGHEPWVSDGTRSGTKALRGLAHGSASSSPRDFVRSGWDVFFSADDGKTGRELWALPFRPKGECKQHHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5W3</accession>
    <name>Q1D5W3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553791.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3778"/>
    <dbReference type="EnsemblBacteria" id="ABF85909">
        <property type="protein sequence ID" value="ABF85909"/>
        <property type="gene ID" value="MXAN_3778"/>
    </dbReference>
    <dbReference type="GeneID" id="41361110"/>
    <dbReference type="KEGG" id="mxa:MXAN_3778"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_8_0_7"/>
    <dbReference type="OMA" id="DGQTEFE"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="6">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF85909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="772" mass="81559" checksum="F6DE1F280B413ACF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6B4</accession>
    <name>Q1D6B4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553640.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3622"/>
    <dbReference type="EnsemblBacteria" id="ABF90420">
        <property type="protein sequence ID" value="ABF90420"/>
        <property type="gene ID" value="MXAN_3622"/>
    </dbReference>
    <dbReference type="GeneID" id="41360960"/>
    <dbReference type="KEGG" id="mxa:MXAN_3622"/>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667008_0_0_7"/>
    <dbReference type="OMA" id="YSRVAMA"/>
    <dbReference type="OrthoDB" id="1371794at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007434">
        <property type="entry name" value="FemAB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04339">
        <property type="entry name" value="FemAB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="412" mass="46790" checksum="E56D65110037D315" modified="2006-07-11" version="1">MTLTLKFHDSVSHLSDAELDALTSESSVFFGRRWFRMLDAVDLSAMARGELSLRYAIAYQQGTPVALCPCFITRSKTIYTPYSLEHFLFTSWKKGFANGPAWSRAAIAAADLYRNVAWRTGAGFDGGVFVTSPLSMRSSILCAAQSVDVAKQARELILQGLRELATSERLPLYFYGVERDDTTLREALTSATFQEIFIYDDNVMDVPGDNFDAYLGQFKSDVRRVLKKEMAHARDTGVRFERVSRMGEMAEQLERFYEVTYSKYGNEHLRHPSTFWAALDQHVSPEAEAVVAYQNGDPIGFSLLLHKNDEMWFYRVGRAEAGASETPLYFNLAFYEPLRRAYELGVKKLWLGASGYETKRRRGARRHGLYSYLWIPGRWSRTVLQPYVSAYSRVAMAMAASGTQNGRIRKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L7</accession>
    <name>Q1D6L7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">carA</name>
        <name evidence="8" type="ORF">MXAN_3512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553542.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3512"/>
    <dbReference type="EnsemblBacteria" id="ABF91170">
        <property type="protein sequence ID" value="ABF91170"/>
        <property type="gene ID" value="MXAN_3512"/>
    </dbReference>
    <dbReference type="GeneID" id="41360857"/>
    <dbReference type="KEGG" id="mxa:MXAN_3512"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_7"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="OrthoDB" id="662268at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="7">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="39823" checksum="508170EEAA58E817" modified="2006-07-11" version="1">MTKRAVLALADGTTFEGRAFGAVGETVGEVVFNTTMYGYQEVLTDPSYVGQIVTMSYPEIGNVGANPEDEEGSRVHAVGMVVRALSEQPSNWRAKESLDAYLKRNGVAGIEGIDTRRLVRHLRTHGAQMGVISSEGLSPLALVERARSARGMEGLDLATGVSTKEAYTFTQPSPDVFTGLGEVRVPAEPRFDVVAYDYGLKKSMLHFLVDVGCRVTVVPANTSAEEVLARKPNGVFLANGPGDPAAVKGADRTVAALLGKVPVFGICLGHQIMALALGGRTYKMKFGHRGGNQPVKDLTTGKVEITAQNHGFAVDDASLKGLAVVTHINLNDGTVEGLAVPDARAFSVQYHPEASPGPHDARYLFDRFAKLMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N7</accession>
    <name>Q1D6N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3491"/>
    <dbReference type="EnsemblBacteria" id="ABF87833">
        <property type="protein sequence ID" value="ABF87833"/>
        <property type="gene ID" value="MXAN_3491"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3491"/>
    <dbReference type="HOGENOM" id="CLU_3292840_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="40" mass="4551" checksum="653FBD2CCD90C9D3" modified="2006-07-11" version="1">MRQARDIARYLALNPDSNHVPETVLFNLPSPINVMNTIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6V2</accession>
    <name>Q1D6V2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553457.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3424"/>
    <dbReference type="EnsemblBacteria" id="ABF86768">
        <property type="protein sequence ID" value="ABF86768"/>
        <property type="gene ID" value="MXAN_3424"/>
    </dbReference>
    <dbReference type="GeneID" id="41360771"/>
    <dbReference type="KEGG" id="mxa:MXAN_3424"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043115_1_0_7"/>
    <dbReference type="OMA" id="PLPLFDW"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="486" mass="52588" checksum="56845BD31A5AB4AF" modified="2006-07-11" version="1">MKTWSSSRWKRPAAGTLVASMLTLGGCVTVPLANDARDVHTTLSARWTPGDPMAGLTSEALRGEDADAAVRALLAQPLTADTAVRIALLNNRDLRAAMHALGIATGNLVQMSLPPNPEVELEMRKPTRGGQPLQGDIGLEYDLSELILLPQRRGVAQAERAAERALTAGEVLHVAYRTRLGFYEVQARHQQLELRNRALQVAQAGYGTAVELEKAGNVRALEVATERSAVESARLAVAEAENALLDSREALNVLLGLFGPRTQWTVDSPLADPVNDLDSGEGLEARAIEASLDLAELRGRMEAADRRHRLARTEGFLPHLSGGFHGEKDEDRWEMGAHLTVGLPLFDRKQGVRMAALSSRESLKARYEATATAIRASLRQASGRVESTGRRARHVRDVLLPARRQVLDETVLQYNAMQVGVFEVLRAQAAVTDTASTYVETLLDHHRARSALEQLLAGRHQGLELGSIRVSSMSASSGPAAAADAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-01-19" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D739</accession>
    <name>PSUG_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="1">PsiMP glycosidase</shortName>
            <ecNumber evidence="1">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psuG</name>
        <name type="ordered locus">MXAN_3335</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553370.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D739"/>
    <dbReference type="SMR" id="Q1D739"/>
    <dbReference type="STRING" id="246197.MXAN_3335"/>
    <dbReference type="EnsemblBacteria" id="ABF92641">
        <property type="protein sequence ID" value="ABF92641"/>
        <property type="gene ID" value="MXAN_3335"/>
    </dbReference>
    <dbReference type="GeneID" id="41360688"/>
    <dbReference type="KEGG" id="mxa:MXAN_3335"/>
    <dbReference type="eggNOG" id="COG2313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_0_1_7"/>
    <dbReference type="OMA" id="RKLGHRD"/>
    <dbReference type="OrthoDB" id="1294333at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000390531" description="Pseudouridine-5'-phosphate glycosidase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <sequence length="303" mass="31787" checksum="B185DAD72985DD85" modified="2006-07-11" version="1">MDLRFSEEVRRALEAGQPLVALETSVVAQGLPYPDNLAAARACEEAIRRAGAVPAATAIIDGQLCVGLEEPEMRRLAEGKERLLKVASRDFAVAMATRATGGTTVSATCEMAAAAGIRVFSTGGIGGVHRGASEHFDISQDIAALARFPVAVVCAGAKSVLDLPKTMELLETAGVPVIGVGTDELPSFYSRGSGIPLEHRADDVDTAARIARARFESLKQGGVLYTVPPPEETSLPRNEVELHIAATLADADRQGIRGKAVTPFLLSEMAKRTGGKTLKANLALLTNNARFAGQLAVAYARAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D753</accession>
    <name>IF1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">MXAN_3321</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002614803.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D753"/>
    <dbReference type="SMR" id="Q1D753"/>
    <dbReference type="STRING" id="246197.MXAN_3321"/>
    <dbReference type="EnsemblBacteria" id="ABF91833">
        <property type="protein sequence ID" value="ABF91833"/>
        <property type="gene ID" value="MXAN_3321"/>
    </dbReference>
    <dbReference type="GeneID" id="41360674"/>
    <dbReference type="GeneID" id="64082922"/>
    <dbReference type="KEGG" id="mxa:MXAN_3321"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_7"/>
    <dbReference type="OMA" id="ECLRSAM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000263826" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8220" checksum="3AD97DF69F4C6197" modified="2006-07-11" version="1">MPKDDSIEVEGTVMEPLPNAMFRVVLDNGHKVLAHISGKMRMHFIRILPGDKVKVELSPYDLTRGRITYRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H9</accession>
    <name>Q1D7H9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553240.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3193"/>
    <dbReference type="EnsemblBacteria" id="ABF85911">
        <property type="protein sequence ID" value="ABF85911"/>
        <property type="gene ID" value="MXAN_3193"/>
    </dbReference>
    <dbReference type="GeneID" id="41360548"/>
    <dbReference type="KEGG" id="mxa:MXAN_3193"/>
    <dbReference type="HOGENOM" id="CLU_976002_0_0_7"/>
    <dbReference type="OMA" id="ERQHDIW"/>
    <dbReference type="OrthoDB" id="1293522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="30368" checksum="1535878185FA9A7C" modified="2006-07-11" version="1">MSRVQSSPSFLPPGTAASEGAAAPAAVPPLTRTAQCRPASAVASSTVEPYRGASSGHSPALSVPGPRSGPRTGADNQFDFGVGGAFPPKPTGNLMEQVRQGALTAAQSEAAAASRLMGDSAAVDGYARIHLEHLKPSPPIPGAPTSLTDYTSSMPDVAPAQAYAYFVRHPSAVFEAAGIRVRPATAALVDGAKLFLEEKGFPPVWAPITVRLEPGANTLHITTLDGHPLRGTNRFVFAEDGAGGTQVRQYSAFQGSSPATSVGMTLMDPIERQHDIWRAVHAHLHDTLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J4</accession>
    <name>Q1D7J4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92054">
        <property type="protein sequence ID" value="ABF92054"/>
        <property type="gene ID" value="MXAN_3176"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3176"/>
    <dbReference type="HOGENOM" id="CLU_2955756_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="59" mass="6606" checksum="265FC7EFB5DCD1C5" modified="2006-07-11" version="1">MVGSTRYQRSPHIDIHLEIEKARERQGQHERTELHLSPPVSNSSGIASVGARFNIPLSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D804</accession>
    <name>XERC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xerC</name>
        <name type="ordered locus">MXAN_3010</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553066.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D804"/>
    <dbReference type="SMR" id="Q1D804"/>
    <dbReference type="STRING" id="246197.MXAN_3010"/>
    <dbReference type="EnsemblBacteria" id="ABF89278">
        <property type="protein sequence ID" value="ABF89278"/>
        <property type="gene ID" value="MXAN_3010"/>
    </dbReference>
    <dbReference type="GeneID" id="41360371"/>
    <dbReference type="KEGG" id="mxa:MXAN_3010"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_7"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0229">DNA integration</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000070018" description="Tyrosine recombinase XerC">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <sequence length="300" mass="33582" checksum="56E3AC4A6CC78A9A" modified="2006-07-11" version="1">MTSLSPLLEKFRAHLEDEKGSSPHTVRNYLIDLVDFERYLVERMKLSLLSGTHAAIRGYLGTLSTDHAPASRARRLASIKSFYKYLVRQKLLPASPAKLVKSPKLPKTLPKVLPVEEVFAILDMPDVKTVLGLRDRAILELLYGGGLRISELCGLDLLDIDRSGRIVRVMGKGSKERLVPVNAQSIRALEAYLARRGELLATIRKDQAPEAMFLNFRGGRLTPRSIARHLDTYVLKCALTRKVSPHAMRHSFATHLLGGGADIRSIQELLGHSSLSTTQRYTQVTWEQLQQVYDSAHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D829</accession>
    <name>Q1D829_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2985"/>
    <dbReference type="EnsemblBacteria" id="ABF89542">
        <property type="protein sequence ID" value="ABF89542"/>
        <property type="gene ID" value="MXAN_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2985"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004398_0_0_7"/>
    <dbReference type="OMA" id="EMSWIYH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="37275" checksum="96B40208E5A46705" modified="2006-07-11" version="1">MISLLQPRGISRIHAPLYRSAACFEYRPRRTRSEKEPQSVKERYQDIDEKNETLRGYLDIYKDKPDAREFLDKMEMSWIYHDAALEGVVYTHQELMAALFPHRTSAEASMIPVVLEIRNHKAVCDFIREEAAGAKKQAQITLTTIKRMHDLFLGNTPEAQTERARMERRERTEKELAKERDRSGLRKDMPLHRTYFHDISQPAKIQPELEKLVDYTASAEFREFHPIKQAATVQHKFVQIFPFTEHSGKVGRMCSNLILLRNGYMPAVIHSIDRQRYYESFRGPAAGFRTVLMDAMENSLDNGMKYFRDLGRKFKALNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8A8</accession>
    <name>Q1D8A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552965.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2904"/>
    <dbReference type="EnsemblBacteria" id="ABF85844">
        <property type="protein sequence ID" value="ABF85844"/>
        <property type="gene ID" value="MXAN_2904"/>
    </dbReference>
    <dbReference type="GeneID" id="41360272"/>
    <dbReference type="KEGG" id="mxa:MXAN_2904"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_3_0_7"/>
    <dbReference type="OMA" id="SWPEYLY"/>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32674" checksum="9D002A4478821B0C" modified="2006-07-11" version="1">MGLSPPSWVGGTWKPDFNVRRPMFEQRFQRNLGVVDAETLDKLSRTHVLVAGVGGAGGQCAVDLARLGVGGVTLADFDVYERHNMNRQVGCFESTLGRSKVEVVGRMCRDIHPALRLREVPEGITEANVEDVLGGGGVQGPVDYVVEVIDIAGAHEKQVLHRACRQRGVPVMTGLMLGFGAALHVFQPDAPLYEALYILPDGRIDLPAIIPHLGSYMLREYMDACFQGRGHAPTCVVGATSAAGMMVTELTRAVMRGPRSMVSWPEYLYVDFFDHSFVRGTAASALARRVDPASRAGGAPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8C1</accession>
    <name>Q1D8C1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552952.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2891"/>
    <dbReference type="EnsemblBacteria" id="ABF89242">
        <property type="protein sequence ID" value="ABF89242"/>
        <property type="gene ID" value="MXAN_2891"/>
    </dbReference>
    <dbReference type="GeneID" id="41360260"/>
    <dbReference type="KEGG" id="mxa:MXAN_2891"/>
    <dbReference type="eggNOG" id="COG3831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049015_0_0_7"/>
    <dbReference type="OrthoDB" id="1000835at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014338">
        <property type="entry name" value="CHP02996_rpt-companion-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="SSF142921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02996">
        <property type="entry name" value="rpt_mate_G_obs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WGR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="449" mass="49563" checksum="60FD5F705AFFC421" modified="2006-07-11" version="1">MPRFEYTEGTSSKFWEIERKDTVVTTRWGRIGTEGQEKTQKFKQTYEALQAYQKQVLEKTKKGYTRIKPKDTAPAAKTNPELEAAILQAPESDDGYLVYADWLQGQGDPRGELMALQHAQRQAQGAESSSLKRKVAALYKKHQGTLLGVGLTSMLGEKALTLEWHLGFIRGARVAAPGFDSDADFDVVETLTMLLRSPSARFLQELTLGLPDNDGDNEYGDLIKVVTRLAPKTLQRLFIGDFVFPDESEISWVKLGNLAPLLKALPHLTTLRLRGGEVRLGPVELPELRRFTMESGGLPRPAVQSIASAKWPKLEQLEVWFGSEEYGGRSRPSDIQSILDATGLPNLKHLGLCNAAFSDELATVLPKAKVLKQLESLDLSKGTLMDTDAEVLAANAAVFKHLKKLDVSQNQLTRKGVKLLASLCPDVAAGNQRDIYDDDEGGRYVAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K4</accession>
    <name>Q1D8K4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2802"/>
    <dbReference type="EnsemblBacteria" id="ABF90433">
        <property type="protein sequence ID" value="ABF90433"/>
        <property type="gene ID" value="MXAN_2802"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2802"/>
    <dbReference type="eggNOG" id="ENOG502ZKQ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1711271_0_0_7"/>
    <dbReference type="OMA" id="PWMRHLA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18488" checksum="298CE87D68F22FC0" modified="2006-07-11" version="1">MCAPARRGLLEEAHMADKRRFDLFADFLVERFNAPRVFDVAGGQGKLNEALTKRGRAVTTFDLRHKHLPVTYAQRIFTLEEPCEAELVVGMHPDGATRIIIQYAAAHRLPFAVVPCCSDNGMPYNPWMRHLAELARESGFTIVEEVKLSMDGRARVLVGEHGAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y4</accession>
    <name>Q1D8Y4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asgA</name>
        <name evidence="6" type="ORF">MXAN_2670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552740.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2670"/>
    <dbReference type="EnsemblBacteria" id="ABF93073">
        <property type="protein sequence ID" value="ABF93073"/>
        <property type="gene ID" value="MXAN_2670"/>
    </dbReference>
    <dbReference type="GeneID" id="41360047"/>
    <dbReference type="KEGG" id="mxa:MXAN_2670"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="PNCVALV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="155"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF93073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42072" checksum="F796CD7FC52DD92E" modified="2006-07-11" version="1">MNPSELPAVLYVDDDALNLRVFDANFGQRFRIFRSSSPSEALALLEQRRGEIGVILSDQRMPGMTGVELLERARTIAPDAKRMLVTAYADMQAVIDAVNRGQVTRYFVKPWDRTELQAALDDALKIARLELRIREVEGRMLKSERLATLGQVTAGIAHELMGPVGYLSQNVASLQRDLGSVIQYVSRHLQTDPEPAVAETVEDLPALIKDLADGAEHLRQVALGLRAQARGEDLEATADVAEVVSFAVKLARAEVRERARLTSNGEPVRVTFGPVKLCQVLLNLIVNAAQAMGTTGRPGRIEVRWTTTPDDVVLTVADNGCGIPMEQQERVFQPMFTTKPVGVGTGLGLSICRELVTQFGGSLRLSSTQGEGTEIEITLRRAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9A6</accession>
    <name>Q1D9A6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552618.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2548"/>
    <dbReference type="EnsemblBacteria" id="ABF86821">
        <property type="protein sequence ID" value="ABF86821"/>
        <property type="gene ID" value="MXAN_2548"/>
    </dbReference>
    <dbReference type="GeneID" id="41359926"/>
    <dbReference type="KEGG" id="mxa:MXAN_2548"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_7"/>
    <dbReference type="OMA" id="GVMHQIR"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="34270" checksum="FA1D74A664EF5B47" modified="2006-07-11" version="1">MNPSKLHTLTVDADKAGQRVDLFIGEALGLSRARLKRLFEAGAVKVNGRPAKKGLTLTAGQHIAVEVEEESREAVPDADFPLTVLHEDDSLVFVDKPAGRPSHPLQSGETGTVANALVARYPECALASLDAREGGLCHRLDVETSGVVVAARTRDAWNAVREAFGSRAVDKRYLALVTGPLTDEGDIDLPLRHHPRHPDRVEPAPYGAEDARDAVSKFTVLSRSGEFSVVEVKILTGVLHQVRAHLAGIGAPIVGDSLYGGREAPELGRFFLHARSLGLTHPQTRRNMTVHSPLPPELRAELERRGLPLPRGEQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D4</accession>
    <name>Q1D9D4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain/tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552591.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2520"/>
    <dbReference type="EnsemblBacteria" id="ABF89006">
        <property type="protein sequence ID" value="ABF89006"/>
        <property type="gene ID" value="MXAN_2520"/>
    </dbReference>
    <dbReference type="GeneID" id="41359897"/>
    <dbReference type="KEGG" id="mxa:MXAN_2520"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408733_0_0_7"/>
    <dbReference type="OMA" id="DQRVDEC"/>
    <dbReference type="OrthoDB" id="282400at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="609"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="704" mass="77424" checksum="A3463EC332B0225E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H9</accession>
    <name>Q1D9H9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2474"/>
    <dbReference type="EnsemblBacteria" id="ABF92933">
        <property type="protein sequence ID" value="ABF92933"/>
        <property type="gene ID" value="MXAN_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2474"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048408_0_0_7"/>
    <dbReference type="OMA" id="RVMKMPF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="182"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="46807" checksum="9FA153331FBF09EB" modified="2006-07-11" version="1">MLLALLALPMMLAGFSPGIGGAVLALDALVLALAVFDVLTARRARLEVHRVLPARLNVGVANKVVVRLIHRSGGAVQVRVRDDVPDGFAATPDEAPLHLPARSESRWVYRVTPVKRGRFQFGDVHVRVRGPLGLVSHERVFPAAQDIAVYPDLRGANRLLLSGAALDLVNLGLRQLRRDGRGSEFARLRDYAQGDSVRDVDWKATARRGRPVTRVLESERSQSILICVDAGRSMAAQVDGLTKLDHAVNAALFLAFVAVRNGDRVGLAVFADGVKAYLPPAAGRTQYRKIVDTLYGTTPSLTYVDYLALFKELNLRLTRRSLLCVFTDFLDEEQASTMVAPLHRLARRHVPLCLSVKDTALQKLLRTPPPSPEEAFQHAVASELLTDREVLKARVSQGGVQMLDVQPDELSLAAVNRYLDIKARGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I8</accession>
    <name>Q1D9I8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552537.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2465"/>
    <dbReference type="EnsemblBacteria" id="ABF86676">
        <property type="protein sequence ID" value="ABF86676"/>
        <property type="gene ID" value="MXAN_2465"/>
    </dbReference>
    <dbReference type="GeneID" id="41359848"/>
    <dbReference type="KEGG" id="mxa:MXAN_2465"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784880_0_0_7"/>
    <dbReference type="OMA" id="GAYGKAH"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="35384" checksum="534A243FA641BF24" modified="2006-07-11" version="1">MAKGDLTRAETFCDLGLEFSPQYADLWSNKGIIAMSSGRQDDAKKHFIKALRYNQEHLQAYQNLGAIYMQEGAYGKAHDNFRRALKVNPDNLESRYNLALTLMKMGKMDESKKELRTILAVNPGISDVHHLLGIISYSKGDYDEAGEHLARATQLVQDSPLLWHDLGTALMELGRYQEARESFANCAQLDPSNSSCINNLSLAQRKTALTDAAFKEIKDTQQAENSAPALFMLARQYREKGLLAEEEATYRKCVKLDAKYAACHFGLYELFFEAHKREHAQIACKNFLKYGTSEEFPTEYQTCERFLSDATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M5</accession>
    <name>Q1D9M5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552503.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2428"/>
    <dbReference type="EnsemblBacteria" id="ABF87939">
        <property type="protein sequence ID" value="ABF87939"/>
        <property type="gene ID" value="MXAN_2428"/>
    </dbReference>
    <dbReference type="GeneID" id="41359812"/>
    <dbReference type="KEGG" id="mxa:MXAN_2428"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_6_7"/>
    <dbReference type="OMA" id="IGENGIW"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="324"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="433" mass="46682" checksum="9529C018F5CBC3FC" modified="2006-07-11" version="1">MLQLFLIAFRNLGTHRRRTLLLGGAIASVTALLVILMGLSTGMKESMLRSATTLSTGHVNVAGFYKVTAGQAAPVVTGYPAILEQIRKDVPELDFAVQRGRGWLKVVSETSSIQVGVGGIDIQSEPGLRQVLQIRAGSLDGLAESGTVLLFEKQAKKLNVQVGESVTLAAQTLRGASNTVDARVVAIAADMGMLSDFGIFVPSDTLRSLYQFKSDTAGALLLYLKDIQHVPAVQARLRQTLTDAGHTVMDHDPRAFFMKFETVNREAWTGQRLDITNWEDEISFITWTLTALNSLTGVLIFVLMVIIGVGIMNTLWIAIRERTREIGTLRAIGMQRTRVLLMFVFEALLLGMLGTLAGASTGLVLCLAVNAMAVHVPEVVAVFIMSDTLNLAVHPSSILGAMAFITACTTAISLIPSFLAARLKPVTAMHHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y8</accession>
    <name>Q1D9Y8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_2315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552390.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2315"/>
    <dbReference type="EnsemblBacteria" id="ABF88584">
        <property type="protein sequence ID" value="ABF88584"/>
        <property type="gene ID" value="MXAN_2315"/>
    </dbReference>
    <dbReference type="GeneID" id="41359702"/>
    <dbReference type="KEGG" id="mxa:MXAN_2315"/>
    <dbReference type="eggNOG" id="COG1718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019779_0_0_7"/>
    <dbReference type="OMA" id="NGGMDPR"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="12">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <end position="471"/>
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            <end position="607"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="607" mass="65052" checksum="997932D4A2D56D84" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA13</accession>
    <name>Q1DA13_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Peptidase, M20E (Gly-X carboxypeptidase) subfamily</fullName>
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    </gene>
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        </lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
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        <property type="gene ID" value="MXAN_2289"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
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            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="488" mass="52472" checksum="A438E27BE9063B5B" modified="2006-07-11" version="1">MPMKRILLSLLFVVVALAGVLLTKAFRFTSRQVQPEAPAEFTVDADAAAARLGGALRLKTLAAAEGQAAEDAAFTALHDYMREQYPRLHQALKREPVGAHSVLYTWTGTDASLRPALLLGHLDVVPVEPGTEASWTHPPYSGLVADGYVWGRGALDDKGSVFGILESVEALLAAGFQPKRTVLLAFGGDEEVGGREGAEAMAKLLRERGVTLESVLDEGGMIVSGTVPGVASPVALVGVSEKGFASAELVADGEGGHSSMPPPQTAVGVLSRAISRLEDAPMPAKLRGGSRALFEFAGPEMGFGMRTLFANLWLFEPLVLRQLTAKATTNAAVRTTTAATMFEGSERDNVLPARARAVVNFRILPGDSVAGVLEHVRRVVDDPRVKVRTLGFISEPSPVSRMDSEAWSQLQRSVRQVFPDVVVAPYLMLGATDSRYFTGLSENVYRFMPLRLDGADLSRLHGKDERVSVKGYADAVRFYAQYVRNVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA42</accession>
    <name>Q1DA42_MYXXD</name>
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        <submittedName>
            <fullName evidence="7">Potassium efflux system family protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2260"/>
    <dbReference type="EnsemblBacteria" id="ABF92808">
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        <property type="gene ID" value="MXAN_2260"/>
    </dbReference>
    <dbReference type="GeneID" id="41359648"/>
    <dbReference type="KEGG" id="mxa:MXAN_2260"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_9_1_7"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RCK_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="6">
        <location>
            <begin position="433"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="583" mass="61201" checksum="679B468A07DB29CD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA61</accession>
    <name>Q1DA61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="246197.MXAN_2241"/>
    <dbReference type="EnsemblBacteria" id="ABF89132">
        <property type="protein sequence ID" value="ABF89132"/>
        <property type="gene ID" value="MXAN_2241"/>
    </dbReference>
    <dbReference type="GeneID" id="41359629"/>
    <dbReference type="KEGG" id="mxa:MXAN_2241"/>
    <dbReference type="eggNOG" id="COG4581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008788_0_0_7"/>
    <dbReference type="OMA" id="KTHYAIE"/>
    <dbReference type="OrthoDB" id="30472at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="822" mass="90762" checksum="B7B3F64522E54578" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG2</accession>
    <name>Q1DAG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90754">
        <property type="protein sequence ID" value="ABF90754"/>
        <property type="gene ID" value="MXAN_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2138"/>
    <dbReference type="HOGENOM" id="CLU_3382846_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="33" mass="3777" checksum="39E158379CC28AD0" modified="2006-07-11" version="1">MKSVGRAAFMTCRFLWLTRQCSSSACTSFRESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAM8</accession>
    <name>Q1DAM8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">MXAN_2066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552150.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2066"/>
    <dbReference type="EnsemblBacteria" id="ABF88258">
        <property type="protein sequence ID" value="ABF88258"/>
        <property type="gene ID" value="MXAN_2066"/>
    </dbReference>
    <dbReference type="GeneID" id="41359475"/>
    <dbReference type="KEGG" id="mxa:MXAN_2066"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_0_1_7"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="566" mass="62713" checksum="D3AD6A0810F3731A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAX5</accession>
    <name>Q1DAX5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552053.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1963"/>
    <dbReference type="EnsemblBacteria" id="ABF90653">
        <property type="protein sequence ID" value="ABF90653"/>
        <property type="gene ID" value="MXAN_1963"/>
    </dbReference>
    <dbReference type="GeneID" id="41359374"/>
    <dbReference type="KEGG" id="mxa:MXAN_1963"/>
    <dbReference type="eggNOG" id="COG3863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516605_0_0_7"/>
    <dbReference type="OMA" id="NIGLPGF"/>
    <dbReference type="OrthoDB" id="500834at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188087" evidence="1">
        <location>
            <begin position="35"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="60113" checksum="CACF036469DC8BBB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ0</accession>
    <name>Q1DAZ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552038.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1945"/>
    <dbReference type="EnsemblBacteria" id="ABF86285">
        <property type="protein sequence ID" value="ABF86285"/>
        <property type="gene ID" value="MXAN_1945"/>
    </dbReference>
    <dbReference type="GeneID" id="41359358"/>
    <dbReference type="KEGG" id="mxa:MXAN_1945"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076882_0_0_7"/>
    <dbReference type="OMA" id="FRAPGYT"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="33987" checksum="4617DACE758359AF" modified="2006-07-11" version="1">MRLASISVDLDSLPHYCRIHGLPESLLDARARSLVHAVAVPRFRELLDGLGITGTFFVIGEDLESDPVAVAGMRASHEAGIEVASHSHAHDYALTRRGPEAIHADLSRADAAILAATGVRPEGFRAPGYTLNADLYEATAALGYRYGSSAFPAVPYYSAKAAVMGALSVLGRPSRSVLDTPRVLLAPRVPYRPDPAQPYRRGSGTVLELPMTVTPALRFPLIGTFATTLPRASLHALWRTCRRDTFFNFELHGVDVLDASDGIPPELVRQQRDLRVSATQKMARLREVFGWLKSEREVLTLRDVAGRLSASV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB00</accession>
    <accession>Q93S46</accession>
    <name>MASK_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Tyrosine-protein kinase MasK</fullName>
            <ecNumber>2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">masK</name>
        <name type="ordered locus">MXAN_1929</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="J. Bacteriol." volume="171" first="819" last="830">
            <title>Gliding motility in Myxococcus xanthus: mgl locus, RNA, and predicted protein products.</title>
            <authorList>
                <person name="Stephens K."/>
                <person name="Hartzell P."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="2464581"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="46" first="1399" last="1413">
            <title>MglA, a small GTPase, interacts with a tyrosine kinase to control type IV pili-mediated motility and development of Myxococcus xanthus.</title>
            <authorList>
                <person name="Thomasson B."/>
                <person name="Link J."/>
                <person name="Stassinopoulos A.G."/>
                <person name="Burke N."/>
                <person name="Plamann L."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="12453225"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2002.03258.x"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
        <scope>INTERACTION WITH MGLA</scope>
    </reference>
    <comment type="function">
        <text>Essential for growth. Interacts with MglA to control social gliding motility.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with MglA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autophosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2"/>
    <dbReference type="EMBL" id="AF377950">
        <property type="protein sequence ID" value="AAK54653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552028.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DB00"/>
    <dbReference type="SMR" id="Q1DB00"/>
    <dbReference type="STRING" id="246197.MXAN_1929"/>
    <dbReference type="EnsemblBacteria" id="ABF90801">
        <property type="protein sequence ID" value="ABF90801"/>
        <property type="gene ID" value="MXAN_1929"/>
    </dbReference>
    <dbReference type="GeneID" id="41359343"/>
    <dbReference type="KEGG" id="mxa:MXAN_1929"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_151_5_7"/>
    <dbReference type="OMA" id="YICMEYL"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="chain" id="PRO_0000282835" description="Tyrosine-protein kinase MasK">
        <location>
            <begin position="1"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="434"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="12453225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="646" mass="68576" checksum="C9667634284FE40C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB62</accession>
    <name>Q1DB62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551967.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1865"/>
    <dbReference type="EnsemblBacteria" id="ABF87665">
        <property type="protein sequence ID" value="ABF87665"/>
        <property type="gene ID" value="MXAN_1865"/>
    </dbReference>
    <dbReference type="GeneID" id="41359281"/>
    <dbReference type="KEGG" id="mxa:MXAN_1865"/>
    <dbReference type="HOGENOM" id="CLU_2917792_0_0_7"/>
    <dbReference type="OMA" id="PVVWPRD"/>
    <dbReference type="OrthoDB" id="2181445at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="61" mass="6433" checksum="BE8CA28F53DDE551" modified="2006-07-11" version="1">MQATSTPTPTSPPTPEGNKTTQESTSMAKAEATPVVWPRDLNLPTSGELTWGFDPEGLCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB63</accession>
    <name>Q1DB63_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1864"/>
    <dbReference type="REBASE" id="13700">
        <property type="entry name" value="M.MxaDKORF1864P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86615">
        <property type="protein sequence ID" value="ABF86615"/>
        <property type="gene ID" value="MXAN_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1864"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642242_0_0_7"/>
    <dbReference type="OMA" id="NYQPAAK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027924">
        <property type="entry name" value="XkdF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14550">
        <property type="entry name" value="Peptidase_S78_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase_S78_2" evidence="8">
        <location>
            <begin position="289"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="46933" checksum="BD3FB340342DA98A" modified="2006-07-11" version="1">MEKTIWGSPAGKKRLAKRLVAMLPAHKTYVEPFAGSAAVLFEKAASDVEAINDADTAIADAYRLIQKLTPAGMAKLKKLPWVGDEKTFKSLFDAKPKGDVERLHRFLYLTHFSYGKLRGRSFSPNGMGVEAKTLARIEQFAPRLKRVKVYSGDYEKVVRKYDGKDTVFFLDPPYPGYNVDVGEGDFDEERFYGVLKSLKGRWLMTYGIRGKLPGMLKGSGFLVKRIRTPRTIAAMRGVGGSSVLTQLLVSNYQPAAKALEGGSDFAVDDWQPEESPDTASFLATMPLLKGVEPDDERYVLGIVLEPETVDAQGDVYSAAEIRQAAHRFMAEFGGLGLMHQMRVNGHVKVLESYLAPVDFNLGEVPVRKGTWLLAVRVLSDELWGRVKDGQLTGFSIGGTARRLPEASPTTEPPPSDTPAADSQPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF0</accession>
    <name>Q1DBF0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1773"/>
    <dbReference type="EnsemblBacteria" id="ABF89707">
        <property type="protein sequence ID" value="ABF89707"/>
        <property type="gene ID" value="MXAN_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1773"/>
    <dbReference type="HOGENOM" id="CLU_2634389_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="77" mass="7497" checksum="5C6418C6C238E53D" modified="2006-07-11" version="1">MAGLAMMGGGGDTPRSPGHFGEVTSAVVLVNPVINEGSTSSVAPSLWGVVWVGLIALAGLDEETGGCCSISPSPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH3</accession>
    <name>Q1DBH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87290">
        <property type="protein sequence ID" value="ABF87290"/>
        <property type="gene ID" value="MXAN_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1750"/>
    <dbReference type="HOGENOM" id="CLU_3346282_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="37" mass="3971" checksum="2594047997E49D8E" modified="2006-07-11" version="1">MDAAKAPFISAEDFPHVEDASRGLRGQGYAYVEDGVT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ3</accession>
    <name>Y1729_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0386 protein MXAN_1729</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_1729</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0386 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF87644" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87644.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020477688.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DBJ3"/>
    <dbReference type="EnsemblBacteria" id="ABF87644">
        <property type="protein sequence ID" value="ABF87644"/>
        <property type="gene ID" value="MXAN_1729"/>
    </dbReference>
    <dbReference type="GeneID" id="41359164"/>
    <dbReference type="KEGG" id="mxa:MXAN_1729"/>
    <dbReference type="eggNOG" id="COG3811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164736_0_0_7"/>
    <dbReference type="OrthoDB" id="2048628at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00827">
        <property type="entry name" value="UPF0386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018654">
        <property type="entry name" value="YjhX_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09857">
        <property type="entry name" value="YjhX_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000252180" description="UPF0386 protein MXAN_1729">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="85" mass="9500" checksum="092F9EF17BE760E4" modified="2006-10-03" version="2">MNVSRKELRVLNVLAQGGRILKHKDENGRLTHVACVTPEGWQLSLCTLEVFQQLKRRKLISSVKGGPYLITRLGLQALCGSSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ8</accession>
    <name>Q1DBJ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1724"/>
    <dbReference type="EnsemblBacteria" id="ABF91396">
        <property type="protein sequence ID" value="ABF91396"/>
        <property type="gene ID" value="MXAN_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1724"/>
    <dbReference type="HOGENOM" id="CLU_2070581_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="118" mass="12549" checksum="387262B1D589AC26" modified="2006-07-11" version="1">MRLIASMLAATALLVGCGGEEQAPETLQEVPVAPAQQKDGEGSVTAMAGPYYYAWSSDNGKRLEICANDLTVHRSNGSTCTLTRGQTFTVYSGGSEWVSGHAWGNCNLDGQVQNGWFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ8</accession>
    <name>Q1DBZ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1573"/>
    <dbReference type="EnsemblBacteria" id="ABF89597">
        <property type="protein sequence ID" value="ABF89597"/>
        <property type="gene ID" value="MXAN_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1573"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_7"/>
    <dbReference type="OMA" id="CEQYISV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="31"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="452"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="552" mass="60331" checksum="B7565701E4CDF511" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB7</accession>
    <name>Q1DCB7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein TonB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_1449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
            <orientation evidence="1 9">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551565.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1449"/>
    <dbReference type="EnsemblBacteria" id="ABF91848">
        <property type="protein sequence ID" value="ABF91848"/>
        <property type="gene ID" value="MXAN_1449"/>
    </dbReference>
    <dbReference type="GeneID" id="41358895"/>
    <dbReference type="KEGG" id="mxa:MXAN_1449"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1057274_0_0_7"/>
    <dbReference type="OMA" id="FGAGMTR"/>
    <dbReference type="OrthoDB" id="1435382at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031992">
        <property type="term" value="F:energy transducer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003538">
        <property type="entry name" value="TonB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01374">
        <property type="entry name" value="TONBPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="26501" checksum="8E4B134FA7152ED8" modified="2006-07-11" version="1">MFDSVLDRGQGPKSRFGVGATVSVILHVALFGLSIWLSTRPPVEEEKEIEVTLKATMAPPPPPPPPPPPPASSSKPKTQPKKPKKPDAIVQPKEIPKEVPKEVEPSEEPPAEEEASEEVVEGGVEGGVVGGVVGGVVGGVIGGVVGGQLGGTGTDVLPFGAGMTRPEKLSGPQPEYSREALEARVQGTMIVKCIVTVEGRVENCRIIKPLPHMDRAVLDALASSRYKPVTFQGRPVQVDYTFTLNFKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCF5</accession>
    <name>Q1DCF5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1411"/>
    <dbReference type="EnsemblBacteria" id="ABF88096">
        <property type="protein sequence ID" value="ABF88096"/>
        <property type="gene ID" value="MXAN_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1411"/>
    <dbReference type="HOGENOM" id="CLU_2863105_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="64" mass="7158" checksum="148921EED5EC83CB" modified="2006-07-11" version="1">MSSRAREMALEMLAVMRRMDDIKGSLRRTLRAASELSPRHWRSCQGTGPGMPGSSFRCHGIRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCG9</accession>
    <name>Q1DCG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase HEAT-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
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        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="56873" checksum="69096543EEDA341C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCY2</accession>
    <name>Q1DCY2_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188405" evidence="1">
        <location>
            <begin position="24"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="30394" checksum="0F3584FF5A4F98D4" modified="2006-07-11" version="1">MSQPARLVLTLVLVWGTATPVAAAQVERAVRKRSVVVATNPTDALPVVRVARDTPTVLLFPAPINRKTLTFDESRIHVLDAGERSVIVQPVADLAEGERYEVGVFFADGRAPARAAFSLVTDPAEVDIQINVQRPELAGATCPVDEPRAPSPEDFVLLGLVDKEGVSATPIKRSRDATQGISVVSAIAYRGNGWVLVDADIRNEAGHSPWTPRVATLTGRVGLPLKARIVQVDSGAIPAGGYGRVLIATETSQLSASPVFTLEIVGDGRTLTLPNVRLPKAASARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD71</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1142</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="gene ID" value="MXAN_1142"/>
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        <property type="component" value="Chromosome"/>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="751" mass="79153" checksum="36CC882124580802" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEH2</accession>
    <name>Q1DEH2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_0683</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_0683"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="IFRRMKM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="467" mass="52188" checksum="308543B0D3C6E5A9" modified="2006-07-11" version="1">MVRSTCASGSSPLQDPFMSQVRLPPGPQGHFIAGNLVEFSEDPLGFLTRCAREYGDVVRLGKRNFLLNHPDLIERVLVNGDGNFVKLAGVGQGKRHKGGFPEAMMNSEGEDWLRKRRLVQPAFHRKHVAACGDTVVALTETMLQTWRPGDARDVHADVSALALDIVSRFLFHTPIDDEARHVADAVDAVMRHTDSPLRPPIWVPTPTNLRLRRALGRLNTLLATLVRRYREQPESRTDLLALLLSAPVPLSENQLRDELATMIMSGHETTADALVWAWYLLAQHPEAEARLVAELETVLGGRLPGAEDLPRLRYTEAVVKEAMRLYSPAWITSREALRDCELGGFHVPAGTMLAVSQWVTHRDARYFDAPESFRPDRWLSEDAQRMHRYVYFPFGGGPRFCIGSALAMMETVLITACVARRFRLELAPGCVVRPRPALALQPLGVWLIPRHRSHTTQEGEVRHAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL0</accession>
    <name>Q1DEL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550776.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0645"/>
    <dbReference type="EnsemblBacteria" id="ABF91865">
        <property type="protein sequence ID" value="ABF91865"/>
        <property type="gene ID" value="MXAN_0645"/>
    </dbReference>
    <dbReference type="GeneID" id="41358122"/>
    <dbReference type="KEGG" id="mxa:MXAN_0645"/>
    <dbReference type="eggNOG" id="COG5407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056992_0_0_7"/>
    <dbReference type="OMA" id="WFLQEAL"/>
    <dbReference type="OrthoDB" id="1303485at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="198"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="29090" checksum="4CDDD58EC9CD25E7" modified="2006-07-11" version="1">MQWVLFFSDRQVREQLFARVDSTRGLLLVTGVRHGAAMRPPEVREPFATLERLHGDVLSQVLVADEGTSDGMWRDPLGDLGDRLHPGSRDDAYAASTGYLLLRDGRPAAVVRKQGTPFEDLWFLQEALSRLTPRVPPPDPAQRPGRRRAEPAPRSPPRPASGGTNARATGTRERTGWDDEATPPRGTRVPPPEPPRKDPWTVLGIAPGTPLDVARKAFRALVVQYHPDKVAHLAPEFHALAELRTREILDAWEEVERALSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL1</accession>
    <name>Q1DEL1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_0644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550775.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0644"/>
    <dbReference type="EnsemblBacteria" id="ABF90010">
        <property type="protein sequence ID" value="ABF90010"/>
        <property type="gene ID" value="MXAN_0644"/>
    </dbReference>
    <dbReference type="GeneID" id="41358121"/>
    <dbReference type="KEGG" id="mxa:MXAN_0644"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_0_1_7"/>
    <dbReference type="OMA" id="CFDYPGQ"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="249"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="833"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="882" mass="98231" checksum="1F5F94A457376DF1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEN3</accession>
    <name>Q1DEN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0622"/>
    <dbReference type="EnsemblBacteria" id="ABF86337">
        <property type="protein sequence ID" value="ABF86337"/>
        <property type="gene ID" value="MXAN_0622"/>
    </dbReference>
    <dbReference type="GeneID" id="41358100"/>
    <dbReference type="KEGG" id="mxa:MXAN_0622"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="DKMFLDN"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="325"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="540" mass="59630" checksum="E5F1802FFB3B86AF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP4</accession>
    <name>Q1DEP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550742.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0611"/>
    <dbReference type="EnsemblBacteria" id="ABF86603">
        <property type="protein sequence ID" value="ABF86603"/>
        <property type="gene ID" value="MXAN_0611"/>
    </dbReference>
    <dbReference type="GeneID" id="41358089"/>
    <dbReference type="KEGG" id="mxa:MXAN_0611"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_7_1_7"/>
    <dbReference type="OMA" id="NHGCSLD"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23479" checksum="5EB04BA1B952C257" modified="2006-07-11" version="1">MDLDALRREQHKRRLSWMPWLYFVLKPRHREWADAWQREVQALLRELETVEIAEGCFIAPEARIFAEPGRTVSIGPGCSIAADVFLHGPVTLGPRVSINARASLDGGSAGIRIGEGTRIATGATLYAFDHGIAPDRPVREQPVTSRGLVIGADVWVGANAGITDGVSVGDHAVVAMGAVVTRDVPAWAIVAGVPARVVGDRRQRPRSGAPGGWEPEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DER9</accession>
    <name>Q1DER9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550717.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0586"/>
    <dbReference type="EnsemblBacteria" id="ABF89506">
        <property type="protein sequence ID" value="ABF89506"/>
        <property type="gene ID" value="MXAN_0586"/>
    </dbReference>
    <dbReference type="GeneID" id="41358065"/>
    <dbReference type="KEGG" id="mxa:MXAN_0586"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372917_0_0_7"/>
    <dbReference type="OMA" id="TTHCQAF"/>
    <dbReference type="OrthoDB" id="426525at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="736" mass="78227" checksum="177ADB4BAA83C6DA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEX0</accession>
    <name>Q1DEX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550666.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0534"/>
    <dbReference type="EnsemblBacteria" id="ABF87825">
        <property type="protein sequence ID" value="ABF87825"/>
        <property type="gene ID" value="MXAN_0534"/>
    </dbReference>
    <dbReference type="GeneID" id="41358017"/>
    <dbReference type="KEGG" id="mxa:MXAN_0534"/>
    <dbReference type="HOGENOM" id="CLU_546077_0_0_7"/>
    <dbReference type="OMA" id="VYATWEA"/>
    <dbReference type="OrthoDB" id="376408at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="507" mass="55682" checksum="9E7229AA93483063" modified="2006-07-11" version="1">MLPGGTTIMTPDLLKDAVSPILRARGTSVLLAALLAACGGKDVRPEAPPAGDCAPLRLERDVNLEGFRTDRFEWRDADCKPRSASLVRNDATDPKGWTGGYLRRYTYEVAGATRVCDGSDGMVPGWGIVTSHLRVSPPWGNWTEGIRGTWRTLFEGRHHALHEFRWPMELGGHVVDVTVHYLFATGRSHPLYAITHDASGAPPDVINADVRSPYGDIIFDGDGNADISGVGWGDRYRFVTLGAGPLTRASGWDYREPNVVPYTRMWIASPDAEMGVVQTQTWVQKPAGGYWQYPSWGQVDEDGPMPEDWNWTYQLNQYELPEQGPTRSHRMAWGSNFGAVGFREYPRYSDDAMLSGYPYQSYSVFMVLGTHTSDPVLRLAADVEAWQGVRLTATEGRVLDRGPGGVGRDDSVARDVPGYNPVYATWEAEVGANNRASLRFETNGRALVNPVLVLRGYTASTPPTRVTLDGQALSADVDYFASVDDAGNALWLTLHRTVTGSAALLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL1</accession>
    <name>Q1DFL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550426.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0282"/>
    <dbReference type="EnsemblBacteria" id="ABF92317">
        <property type="protein sequence ID" value="ABF92317"/>
        <property type="gene ID" value="MXAN_0282"/>
    </dbReference>
    <dbReference type="GeneID" id="41357782"/>
    <dbReference type="KEGG" id="mxa:MXAN_0282"/>
    <dbReference type="eggNOG" id="COG1913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108521_2_0_7"/>
    <dbReference type="OMA" id="KDRGQYH"/>
    <dbReference type="OrthoDB" id="1765947at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
        <property type="entry name" value="Pept_M54_archaemetzncn_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="19368" checksum="8284E4B5D4855366" modified="2006-07-11" version="1">MPQKTLLLVSVGSPPASLLRDLQDPLAAQMGVAAVVSKTVLPTPAYAFNKDRGQYHCNAIMRRLTPMQEPGQFAVLGISDVDLFVPDSPFVFGEADRESKTAVMSLHRLAQGAASEMLRRRAQVEVVHQAGHLLGLSYCEDPRCVMFFAQTPQDCDRKQLSLCNLCRNELQKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM9</accession>
    <name>Q1DFM9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550408.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0263"/>
    <dbReference type="EnsemblBacteria" id="ABF88391">
        <property type="protein sequence ID" value="ABF88391"/>
        <property type="gene ID" value="MXAN_0263"/>
    </dbReference>
    <dbReference type="GeneID" id="41357763"/>
    <dbReference type="KEGG" id="mxa:MXAN_0263"/>
    <dbReference type="HOGENOM" id="CLU_1728299_0_0_7"/>
    <dbReference type="OMA" id="LHWGQID"/>
    <dbReference type="OrthoDB" id="1435381at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="16867" checksum="EF0E11D5AA30B416" modified="2006-07-11" version="1">MSSPRFYAFDPRATRIALFVGACVLAVLTAWALADARAEGGVQAMARAGVSAGLMLTFLVSFHRLRPRTGWGVTVDARGVRVARPFSQKELDLHWGQIDHVRRIGRKGSVLALFLKEEGRVLVTRHLFARKAVFDELISALEDRLPPPRFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFP9</accession>
    <name>Q1DFP9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550388.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0243"/>
    <dbReference type="EnsemblBacteria" id="ABF89001">
        <property type="protein sequence ID" value="ABF89001"/>
        <property type="gene ID" value="MXAN_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="41357743"/>
    <dbReference type="KEGG" id="mxa:MXAN_0243"/>
    <dbReference type="eggNOG" id="ENOG502ZZV4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077132_0_0_7"/>
    <dbReference type="OMA" id="HPPEMME"/>
    <dbReference type="OrthoDB" id="1664282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="26278" checksum="5A6F306D2A1D2AE5" modified="2006-07-11" version="1">MTRFFWLREDEAATAAFSGSFNAAHKWCLPGVKCSACGTTWSSWGNHYPLVDLSQLPERAAFEKARPEPFTEFSRLRELVRSLAPPDAELPPGAAFGPLVGTASGEFGPFTWQGTSLLLVRRDAMERLQAEGVRGLLGGQTELRFRKKESPELLDLQLEPRGLLHPDCIPSDASPPCPTCGRHAFARPDAPILAAASLPADVDAFRLVNFATMIIGTDRFVDAMRRLGLEGIACQELPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFV3</accession>
    <name>Q1DFV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550334.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0188"/>
    <dbReference type="EnsemblBacteria" id="ABF91498">
        <property type="protein sequence ID" value="ABF91498"/>
        <property type="gene ID" value="MXAN_0188"/>
    </dbReference>
    <dbReference type="GeneID" id="41357691"/>
    <dbReference type="KEGG" id="mxa:MXAN_0188"/>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854794_0_0_7"/>
    <dbReference type="OMA" id="NMGFTEP"/>
    <dbReference type="OrthoDB" id="1022010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188518" evidence="2">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="35863" checksum="C31284690223A2DB" modified="2006-07-11" version="1">MRLTSSRLSLVALLLMATSAVAASSTFEPRGTWSASPKSSDPSTLNLQLRQGPHRNMGFTEPLASFQGLSTTGGATTFTLPREAGTFHFEGQFQDSQGAGHFRFDASSDFLKKLATLGYSDITPEVQFQLAATNVTTARIQGLAALGYKQLSTEELIQAGIFDVTPEYVRGLSDAGYPGLSFKELVESRIHRVTPQRVKEFSGVGFAKLPWNQLTAMSIHGVTPDFVKQMRELGFQGTDADDVIAFRIHRVTPDFVKQMRELGFKDLTQDQILAFRIHGVTPDFVKQMREAGYPNVTPDELVTLRIHGIDRIFIRDMSGTAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB9</accession>
    <name>Q1DGB9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0021"/>
    <dbReference type="EnsemblBacteria" id="ABF89030">
        <property type="protein sequence ID" value="ABF89030"/>
        <property type="gene ID" value="MXAN_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0021"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522556_0_0_7"/>
    <dbReference type="OMA" id="VEDEWTH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="521" mass="55544" checksum="4E5CEB305F5E17BB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH5</accession>
    <name>Q1CVH5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_7495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557397.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7495"/>
    <dbReference type="EnsemblBacteria" id="ABF91582">
        <property type="protein sequence ID" value="ABF91582"/>
        <property type="gene ID" value="MXAN_7495"/>
    </dbReference>
    <dbReference type="GeneID" id="41364628"/>
    <dbReference type="KEGG" id="mxa:MXAN_7495"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_7"/>
    <dbReference type="OMA" id="ITVIIME"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="13"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="420" mass="43559" checksum="444B14DEA12BF722" modified="2006-07-11" version="1">MTTPSTQSIEKGTLGLELLLGTLTAFAPLSIDMYLPALPRIAEDLQSTAPAIQLTLASCFAGLALGQLFTGPLIDRFGRTRPLYAGLALYVLGSLGCALAPSASMLVAMRFVQALGGSVALVVPRAVVRDLWSGANAARTMSRLMLVMGVAPILAPLLGGMVLQYSGWRAIFVVLAAVGAVALAFVLKSLPETAPPHVGAQSMRSRMGALMKDPDFVGPALAGGFAQAGMFAYIAGSPFVFISLYGIPEEHFGWFFGVNAMGLIAVAQLNRKLVTHLPLHRLLRLALSLCVVAAVAVLAVAWTGFMGLWGIAVTLFFFVSAMGLVGPNAAAIALERHATRAGMASAALGALQFTAAAGASWAVSTFNNGTAMPMAGVMTAMALLAWLAAFFGLRARTRQQEAGEGAQAHGPRIVSSSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVM7</accession>
    <name>Q1CVM7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7441"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90473">
        <property type="protein sequence ID" value="ABF90473"/>
        <property type="gene ID" value="MXAN_7441"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7441"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052026_0_0_7"/>
    <dbReference type="OMA" id="HVTFVKY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="290"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="53398" checksum="A493FA3C70A4CF1C" modified="2006-07-11" version="1">MDDGAAHGGQHQESKQCAVAQVGRPVGCVHRDPEEATSGERVGIDGVARMPAPRPRVLLIAELCNPDWVSVPLEGWSLYRALAEVADVHLVTHVRNRENILKQGVQEGSQFTALDSTPVEKPLDKVGEVLRGKTGVGWTTATALSALPYYYFEEVLWRRFGPRIEAGEFDLVHRYTPISPTTPSTLAARCKKAGVPFVMGPLNGGLPWPKGFGGARRREKEWLSYIRDVYKLMPFYKSTRENASAIITGSRATRGQVSGQWQGKTVYVPENAIDTRRFGTEKSEGPVELPLRVAFVGRFVPYKGMAMLMEAAAPLIREGKVVLEYIGDGQEMANLRAQAAREGIESGVTFAGWVKHQELQGRLAKNHIFGFPSVREFGGAVVCEAMALGLVPIVMDYGGPGEIVSPATGFAIQMGTPEEIVLRVREVLTKLAADPSVIRPMGERARERIFKYFTWRAKAEQVLEVYRWVKGERGQPDWGMPLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ9</accession>
    <name>Q1CVZ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557230.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7311"/>
    <dbReference type="EnsemblBacteria" id="ABF92260">
        <property type="protein sequence ID" value="ABF92260"/>
        <property type="gene ID" value="MXAN_7311"/>
    </dbReference>
    <dbReference type="GeneID" id="41364474"/>
    <dbReference type="KEGG" id="mxa:MXAN_7311"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_0_0_7"/>
    <dbReference type="OMA" id="GNVQCLD"/>
    <dbReference type="OrthoDB" id="433393at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="1 3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="6">
        <location>
            <begin position="18"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="5">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="4">
        <location>
            <begin position="295"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="558" mass="60748" checksum="F660C941C668201C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW39</accession>
    <name>Q1CW39_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557190.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7271"/>
    <dbReference type="EnsemblBacteria" id="ABF91374">
        <property type="protein sequence ID" value="ABF91374"/>
        <property type="gene ID" value="MXAN_7271"/>
    </dbReference>
    <dbReference type="GeneID" id="41364436"/>
    <dbReference type="KEGG" id="mxa:MXAN_7271"/>
    <dbReference type="eggNOG" id="ENOG5032JJZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933268_0_0_7"/>
    <dbReference type="OMA" id="HHADYSK"/>
    <dbReference type="OrthoDB" id="840081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="31189" checksum="2FF06C5D278F1238" modified="2006-07-11" version="1">MKGIKFGGFKSPSIPKSSGPNKPSAPPPVESKPASKPSPVKDGFDAQGSKPSTSTVNPQPTRQPGKDVTSSFGANPLGYSGQNVLNAYNMSPSGALQGVALPTAQKPFVNASDAVVTLNAHQHQGNTNLSVSPAGGQGIPAHYMHYLSTGEGKFAGIQGVPLHPRPGEPHTVVTGALNGCAIHALHDTKNNSLSFLHHADYSKNGKAELDGFLSQHPNLKPAGSFTPSDYSHPTGKYNDPTGATPFIHYSQGAGNRPGQWTIAGQLNTFKSGGAEGGRPALMRPTDLQVPLMQTIPVDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW84</accession>
    <name>Q1CW84_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557145.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7226"/>
    <dbReference type="EnsemblBacteria" id="ABF88495">
        <property type="protein sequence ID" value="ABF88495"/>
        <property type="gene ID" value="MXAN_7226"/>
    </dbReference>
    <dbReference type="GeneID" id="41364395"/>
    <dbReference type="KEGG" id="mxa:MXAN_7226"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="IMITHNR"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="265" mass="28982" checksum="AC078347F75069D3" modified="2006-07-11" version="1">MSPSSPPSSRQLAIEVRDLHKSFGDQQALRGVNLEVPEGTTCVLMGVSGSGKTVLMKHIMALLQPDRGTVLVDGEDIARMNEAALDQMRRKQGILFQANALFDSLTVFDNVAFPLRERTRMPEAEIAETVNKTLERVGLSHATQRFPGELSGGMQKRVGFARATILQPKILLYDDPTAGLDPLTTAAVNEIITTGKQQLGATSLVITPDVASAFGMADHLALMHEGRIVEYGPPDAFRESQHPAVMAFLRNWLRRRAQNKRAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW86</accession>
    <name>Q1CW86_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91854">
        <property type="protein sequence ID" value="ABF91854"/>
        <property type="gene ID" value="MXAN_7224"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7224"/>
    <dbReference type="eggNOG" id="COG1873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150891_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26642" checksum="D1E171AFC6C3D6B9" modified="2006-07-11" version="1">MVQPLISLAQQVAMGVRVRMGHLFQERAQRCVQRLLHVARLHGGQFQQHGAPPAWNVRHAPAHVASMPARSTPGLAAWRLAFSWQDMRFGGPCVRVVVERRAVVASAPPCAPLQVRPVMPARTVVWESRTGRAPEREEAGMIRTDDVHEGMTVRTATGHVIGRVAGIGDTHFELEQGLVPIPRRDYLVEFSDVDFIRGHDVYLVNADHPLLALEVDDDGGALPPRHSEGLEREPVNVDVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWL7</accession>
    <name>Q1CWL7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fghA</name>
        <name evidence="8" type="ORF">MXAN_7093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + S-formylglutathione = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557012.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7093"/>
    <dbReference type="ESTHER" id="myxxd-q1cwl7">
        <property type="family name" value="A85-EsteraseD-FGH"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.940"/>
    <dbReference type="EnsemblBacteria" id="ABF89635">
        <property type="protein sequence ID" value="ABF89635"/>
        <property type="gene ID" value="MXAN_7093"/>
    </dbReference>
    <dbReference type="GeneID" id="41364268"/>
    <dbReference type="KEGG" id="mxa:MXAN_7093"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056472_0_0_7"/>
    <dbReference type="OMA" id="TFMEDHL"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="PTHR10061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="30946" checksum="4DFD550F091AE4F9" modified="2006-07-11" version="1">MERIEHHASFGGRQEVWKHTSSALGGETRFGIYLPEAALRGERCPVLYWLSGLTCTEQNFITKAGAQEHAARHGFIVVAPDTSPRGDAVANDAAYDLGQGAGFYLDATQAPWAPHFRMQDYVARELPALVEQHFPATDARGIFGHSMGGHGALVTALRHPGRYRSVSAFSPIVAPSQVPWGQKAFTAYLGDNRAAWAAWDAVELVKTAKERLTLLVDQGEADEFLATQLRPELLAAACEATGHPLTLRRHAGYDHSYYFIATFLADHFAHHAKALVGSEKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ6</accession>
    <name>Q1CXQ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556625.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6700"/>
    <dbReference type="EnsemblBacteria" id="ABF90978">
        <property type="protein sequence ID" value="ABF90978"/>
        <property type="gene ID" value="MXAN_6700"/>
    </dbReference>
    <dbReference type="GeneID" id="41363893"/>
    <dbReference type="KEGG" id="mxa:MXAN_6700"/>
    <dbReference type="HOGENOM" id="CLU_1068859_0_0_7"/>
    <dbReference type="OMA" id="NCVEFQG"/>
    <dbReference type="OrthoDB" id="1255294at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188017" evidence="1">
        <location>
            <begin position="46"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="31077" checksum="A7B32CCC528B8FF5" modified="2006-07-11" version="1">MNWLLPSSGIPPGSSGAFMRSSRRVGTALWAAVFSLALPLSQAHAAENCVEFQGLQHCGLGAVKVSDLRKGVRIDSQEKEPSGKGGVAIHTPPAAAWTAETQSEGAQRNFFTAYAEDVPVSTSTVDSSRESTSYSATFTGSGDATTYSVLAYYNGRLQAAVGGIQSGDTGAVGIMLPTPGWTPNCRPRTQTYAQCESACYANGYSNCNYCNTLCSLTVGFASAQLSSACLWQYNVAEPGVRLPNGQIVRADQIVLQEETSGPSNYPYLNFNRIDVQTTARSTVITGESLIPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ9</accession>
    <name>Q1CXQ9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">thiL</name>
        <name evidence="6" type="ORF">MXAN_6697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556622.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6697"/>
    <dbReference type="EnsemblBacteria" id="ABF92942">
        <property type="protein sequence ID" value="ABF92942"/>
        <property type="gene ID" value="MXAN_6697"/>
    </dbReference>
    <dbReference type="GeneID" id="41363890"/>
    <dbReference type="KEGG" id="mxa:MXAN_6697"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_1_1_7"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="4">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="5">
        <location>
            <begin position="148"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="315" mass="33275" checksum="6557B6475E4E61D4" modified="2006-07-11" version="1">MSGEFDFIRRFLAHFPAARVPVGPGDDCAVLPPSRGAQCVTTDAVVEDVHFTRAAFSPADIGHKALAVNLSDLASMGATPRWFVCALALPKDYPLRELTGLARGMAALATAHRIALVGGNFTSARELSVTITAAGELSRAPLTRAGARPGDLLYVSGTLGDARLGLEHLRAGLRRGAAVRRQRRPEPRVALGLLASRHASAALDVSDGLAQDLGHLCTASGVRAELEVERLPLSAAVRKALGPEGALAGGEDYELLLAVPPGRSRAFERACATGGHAITRIGHFTEGRGWVGRDRTGRVLPPPEGFDHFRPRAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXV2</accession>
    <name>Q1CXV2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556579.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6654"/>
    <dbReference type="EnsemblBacteria" id="ABF86699">
        <property type="protein sequence ID" value="ABF86699"/>
        <property type="gene ID" value="MXAN_6654"/>
    </dbReference>
    <dbReference type="GeneID" id="41363852"/>
    <dbReference type="KEGG" id="mxa:MXAN_6654"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056292_2_0_7"/>
    <dbReference type="OMA" id="VAPNLMH"/>
    <dbReference type="OrthoDB" id="313524at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="PTHR33835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="25064" checksum="958AFD41E5F03A80" modified="2006-07-11" version="1">MFRQVADDVHVLAVEFRIGGMDLGGRMTAVRLPDGGLWLHSPVRFSPEVRAAVDALGPVRFLVAPNLMHHLYVQEWAAAYPDAKVAAPAALRRKRPDLRIDLELGDTAEAGWAGVLDQVLVQGMPKVDELLFFHRPSQTLFVTDLAFNVHRTGSWFTRMYLKLSGAWQRLAPTMLVRSVIKDREAVRASLARTQAWDVERVVVCHGDVVEQGGREAVRNAFARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX4</accession>
    <name>Q1CXX4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556557.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6631"/>
    <dbReference type="EnsemblBacteria" id="ABF86185">
        <property type="protein sequence ID" value="ABF86185"/>
        <property type="gene ID" value="MXAN_6631"/>
    </dbReference>
    <dbReference type="GeneID" id="41363829"/>
    <dbReference type="KEGG" id="mxa:MXAN_6631"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_7"/>
    <dbReference type="OMA" id="VVHTDYV"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="25956" checksum="31DA65440600ABED" modified="2006-07-11" version="1">MKKVLVLGATSAIAQATVRLLAARGASLYLTGRNAANLDAVTKDAATRGAAKVASQVVDLNDFDTHEALVEAAYTALDGLDGVVLAHGVLGDQAEAQRSWAATEAVLRTNFLSAVSLLTVLANRFEAQKAGTLVVISSVAGDRGRQSNYVYGASKGALNVFLQGLRNRLAKSNVAVVTVKPGFVDTPMTAHLPKNKLFASPEKVARGLLSAADSRKNEVYVPGIWALIMLIIRTIPETVFKRMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ7</accession>
    <name>Q1CXZ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556534.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6608"/>
    <dbReference type="EnsemblBacteria" id="ABF92753">
        <property type="protein sequence ID" value="ABF92753"/>
        <property type="gene ID" value="MXAN_6608"/>
    </dbReference>
    <dbReference type="GeneID" id="41363806"/>
    <dbReference type="KEGG" id="mxa:MXAN_6608"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_7"/>
    <dbReference type="OMA" id="ADHKEAA"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="27508" checksum="F0CA87BC1C835C74" modified="2006-07-11" version="1">MSAPAAEVLLEVEGAVATLTLNDTARRNVMTPELGDALCARVAELKGRDDVRAVVLTGAGGAFSAGGDLKMLERLRQVSFEDARAFMLGFYARYLSVLDLPVPVIAAVDGPAIGAGLCVALACDVCLVAEDSKLALNFVQLGLHPGMGATYLAPRRAGAQAAAELLLTGRRFDGKEAVKLGLALEAAPAGQVLTRARELAGRIAANAPLAMRALKQRLGLDRAELQRALEEEARFQAESYGSQDLGEGLAAAAARRAPVFQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYH0</accession>
    <name>Q1CYH0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556361.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6429"/>
    <dbReference type="EnsemblBacteria" id="ABF92044">
        <property type="protein sequence ID" value="ABF92044"/>
        <property type="gene ID" value="MXAN_6429"/>
    </dbReference>
    <dbReference type="GeneID" id="41363639"/>
    <dbReference type="KEGG" id="mxa:MXAN_6429"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029774_0_0_7"/>
    <dbReference type="OMA" id="ISEFRVH"/>
    <dbReference type="OrthoDB" id="351831at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="627" mass="65722" checksum="661578DBC22C3813" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI1</accession>
    <name>Q1CYI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556350.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6418"/>
    <dbReference type="EnsemblBacteria" id="ABF85838">
        <property type="protein sequence ID" value="ABF85838"/>
        <property type="gene ID" value="MXAN_6418"/>
    </dbReference>
    <dbReference type="GeneID" id="41363628"/>
    <dbReference type="KEGG" id="mxa:MXAN_6418"/>
    <dbReference type="HOGENOM" id="CLU_1370914_0_0_7"/>
    <dbReference type="OMA" id="PTENGYD"/>
    <dbReference type="OrthoDB" id="1309773at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="21359" checksum="F1D8452891D431EA" modified="2006-07-11" version="1">MHVKRLALAALPVTAVAVAMACYSEPVYPGDQVLGSFRFEARLDAARTTCDASVPDFAQLNDAGVFLFEGTFSRDTDAGTGFFTVQGYSRDAGYEGQVATSTLKAVAPRASCGTGCEDSSIEETLRVTLFSDSQARTLSRDCRQFDGGIPDGSVPGPTENGYDVSLACGSLTDIFLPGTRNCNCQPTTCTTVYTVQGERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZF1</accession>
    <name>Q1CZF1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaD</name>
        <name evidence="11" type="ORF">MXAN_6087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556036.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6087"/>
    <dbReference type="EnsemblBacteria" id="ABF89720">
        <property type="protein sequence ID" value="ABF89720"/>
        <property type="gene ID" value="MXAN_6087"/>
    </dbReference>
    <dbReference type="GeneID" id="41363323"/>
    <dbReference type="KEGG" id="mxa:MXAN_6087"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_7"/>
    <dbReference type="OMA" id="GIVMVWF"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="36"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="556" mass="61594" checksum="675DE34916967669" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZM2</accession>
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        <submittedName>
            <fullName evidence="3">Oxidoreductase, NAD-dependent</fullName>
        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABF92507">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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    </dbReference>
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            <end position="187"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF92507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="38466" checksum="5781CA3C90109669" modified="2006-07-11" version="1">MSRVSTPPVPAPRLAGEPSYSQRSCGTGGRDGFSFPSSHPPCGLAMGGRMSLVEARASRARKPVEYEVTVDHVRMDTHDTATLFLDFGGVPVDYKAGQFLNIDPHQFPALGRLSAYLQEQKGRKEPQRSYSLASAPHEPLVAITVKDEEFVPGLTRYPPLLSPYLVHGRLTGARMKVMAFMGPYVLPEDVEERTEHVVHLVAGSGAVPNFAILKDALHRGLKLRHTFLFSNKTWGDVLYGEELAALERQHPDRVRVVHTLTRETDESRFGAAVRKGRVHQSLLEELIQDRDTCLVYACGPAITPWDRRKALETRTPSTPRFMETVLGHLHALGIEDKRIKRETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZT8</accession>
    <name>Q1CZT8_MYXXD</name>
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        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
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                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88236">
        <property type="protein sequence ID" value="ABF88236"/>
        <property type="gene ID" value="MXAN_5948"/>
    </dbReference>
    <dbReference type="GeneID" id="41363187"/>
    <dbReference type="KEGG" id="mxa:MXAN_5948"/>
    <dbReference type="HOGENOM" id="CLU_1204204_0_0_7"/>
    <dbReference type="OMA" id="CGYSECR"/>
    <dbReference type="OrthoDB" id="2097267at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187755" evidence="3">
        <location>
            <begin position="31"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="230" mass="23216" checksum="39345CBC7BD6DBB0" modified="2006-07-11" version="1">MLSLRAPAPMLSHPNRPILLTLLLPALALAQPTDDAPRMPGPVTATQQRPAVGRPSPAAPRIHPSQDAPFPLGARLVGETVGGALIGASGLAVTFLGGVLVSDQVSCGYSECRSGRNLSLISASIGMGLGAASGVYLGGSLMDARGGFLPTLLGGLVGTAAPLAVVALSDEASWAVLTATFAVPVATSILAFELSHGAYERRRQQERPVVMVPTVSLAPGGGALGLAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0M1</accession>
    <name>Q1D0M1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555617.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5664"/>
    <dbReference type="EnsemblBacteria" id="ABF87574">
        <property type="protein sequence ID" value="ABF87574"/>
        <property type="gene ID" value="MXAN_5664"/>
    </dbReference>
    <dbReference type="GeneID" id="41362909"/>
    <dbReference type="KEGG" id="mxa:MXAN_5664"/>
    <dbReference type="eggNOG" id="ENOG50337KD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_792043_0_0_7"/>
    <dbReference type="OMA" id="DHRYELK"/>
    <dbReference type="OrthoDB" id="1224824at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188115" evidence="2">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="37142" checksum="B07B75CB1C4CBF6A" modified="2006-07-11" version="1">MNRLIPLLAVWLVVAALVVAAPAWAQAPAPAPAPATTEQVEPRNLSVRLEPQQVRIGDPFVYEVVITHPKDHRYELKVPQETGDFEFLDQTRQRQDGPDSATTTFRVRMSAFALGSVAVPALPFDVATPEGPKAFTVPGRTVDVTSTLSPDAEGQGADLFDYKPPEEVPIRSWRLVLTVLGVLAAALLAWVLFRWWRNRPKHVEVVPTLPLDVRARKALDALKAEDLPSRGRVKDFYFRLSEIIRGYLGERYGFEALECTSSELMASLRRLSTPGLPEDKLMRFVSESDMVKYARADASADACRDALAFGYSLIDTTYVPPPPPQAPDNAAAPRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D114</accession>
    <name>Q1D114_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555474.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5516"/>
    <dbReference type="EnsemblBacteria" id="ABF87874">
        <property type="protein sequence ID" value="ABF87874"/>
        <property type="gene ID" value="MXAN_5516"/>
    </dbReference>
    <dbReference type="GeneID" id="41362769"/>
    <dbReference type="KEGG" id="mxa:MXAN_5516"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_7"/>
    <dbReference type="OMA" id="KRVDKRY"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="33238" checksum="56E372294AEB2832" modified="2006-07-11" version="1">MAQQKVQVPREAAGERLDRFLSKQVPGINLERARALIDSGAVRIRGKRCQPTRKLWGGEEIELERPEPRAASVAASEGPVLPVLHDDSALVIVNKPPGIVVEPEGRAASVVGLLAAQRPPFDVEGLAQPGVVHRLDRETSGCLAFARTDTAAAALLRSFQEKRVDKRYWTLVLGQPPAQGRLEGPYARDPADPRRFTTRVPSARRAALSFEVRERFADAALLEVDLDTGRTHQVRVQLSEAGFPVLADSLYGPPEARAHAAARALGRQALHAFTLELPSPATGQPVRVEAPLPEDFQRALTVLRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D131</accession>
    <name>Q1D131_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555457.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5499"/>
    <dbReference type="EnsemblBacteria" id="ABF91539">
        <property type="protein sequence ID" value="ABF91539"/>
        <property type="gene ID" value="MXAN_5499"/>
    </dbReference>
    <dbReference type="GeneID" id="41362753"/>
    <dbReference type="KEGG" id="mxa:MXAN_5499"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707549_0_0_7"/>
    <dbReference type="OMA" id="GDKQLDR"/>
    <dbReference type="OrthoDB" id="744070at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="41745" checksum="B4802230C8C794CE" modified="2006-07-11" version="1">MAVSKLASSAARLMKQGLLKEAARDFERAIEQDPKDASALLGLARLRLAQHDETAARAVLQRLVALHPTHPEALSHLARLDAEKGDARQLDLLAALAAQPKAGFFEVINHGRALLGHDRYAAAIPELERALALQPGNAQTLTYLGMALQGDKQLDRALRRYLEAAEANKTEHLPLQLAARVQLLQGHVGAAIVTLRQAILRSPRETALFREFASLCLMAGAPEAAMRAAIELRLQLPDSADAIYLHGISAFVAGKDEDADRILREALAKAPESAPVRVALAKVRRKLGDDAEAQTLLEAAVATDPSEAGAANDLAVLHLSRPGGAAAARAILTEALKHHPDDAGVHLNLALALADSDKAQALTHARRAQASTHRDIREQAERLVTALSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D175</accession>
    <name>Q1D175_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5455"/>
    <dbReference type="EnsemblBacteria" id="ABF87009">
        <property type="protein sequence ID" value="ABF87009"/>
        <property type="gene ID" value="MXAN_5455"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5455"/>
    <dbReference type="HOGENOM" id="CLU_014174_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026435">
        <property type="entry name" value="Myxo_Cys_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04201">
        <property type="entry name" value="Myxo_Cys_RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="816" mass="84387" checksum="D15A03A158FC54CB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B6</accession>
    <name>Q1D1B6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5410"/>
    <dbReference type="EnsemblBacteria" id="ABF89377">
        <property type="protein sequence ID" value="ABF89377"/>
        <property type="gene ID" value="MXAN_5410"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5410"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_1_7"/>
    <dbReference type="OMA" id="AAETDWV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="420" mass="45588" checksum="FDA3D73386BA486B" modified="2006-07-11" version="1">MMTESRDIRIEHLLREHAPRVLGAVIRRFRDFGASEDAVQEALLAAALQWPREGVPDDPRAWLIQVASRRITDHVRAETARRHREELVVSLVPPELQLVMSLDGDELAGRDDALVLLFMCCHPALSTASAIALTLRAVGGLTTAEIAKAFLVPEATMAQRISRAKQSIKSSGIPFQKPTPEESAQRLGAVLHVLYLIFNEGYTATSGPELHRTDLSGEAIRLTRMLHTLLPEDGEVAGLLALMLLTDARRAARTGPAGELIPLDAQDRSLWDAGMIAEGIALISATLSRGSVGMYQVQAAIAAVHDEASRAEDTDWPQVLALYGVLMGLMDNPMVALNHAIATAMVHGPQAGLSLLEGLAREGRLEGNHRLDAVRAHLLERAGKTGAAVVHYRKAAERTTSLPERDYLLTQAARLSDEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1D5</accession>
    <name>Q1D1D5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88601">
        <property type="protein sequence ID" value="ABF88601"/>
        <property type="gene ID" value="MXAN_5391"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5391"/>
    <dbReference type="HOGENOM" id="CLU_543830_0_0_7"/>
    <dbReference type="OMA" id="FFVAWSD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="47249" checksum="62B545B7BEE62D24" modified="2006-07-11" version="1">MQGQTMSLRTWRGALLGAFLAISCGGEPEAAFEDPSLQGDLELGLHGNGGQGPLPNWSTPTFANNAQVAEDGNQFFVAWSDWSRAGKLVAARVSVNGRLLDPDAIELNPNLRPDAYYHATAFDGRQFLVIWTGERAVFLTRVNRDGTLDGDPITLFTPTDHNAVGSPGIACHKRKCLVAWIASGHTVSREVRGVTLDMGKRGLDVQEVVISRSQSTEFSSGISVAWSEDQYLVAWTDTRYGSHDIFAARVRANGSVLDPNGFIISAAPGNQNYQSVTATKYGFFVAWSDSRSGSADIYGTRLKRGSANVLDPLGIRISTASTTELSPRVASEGDEVLVSWSALTADTARVRAARVKRNGDVRDRNGFAISKGPANRQLLFGNVAYASGRYFIVYGRAPVMDEPPYQVMVGTRVKNDDVVDNPAIRISHAPSVEQLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1E2</accession>
    <name>Q1D1E2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90470">
        <property type="protein sequence ID" value="ABF90470"/>
        <property type="gene ID" value="MXAN_5384"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5384"/>
    <dbReference type="HOGENOM" id="CLU_1766046_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="16299" checksum="5AE2789A0E6287BD" modified="2006-07-11" version="1">MWPQCAAPAPLAGAAWRWTSRARRRHPPRTCAVDVLVDGVPTGPQDVMVQCAQKAEALQAPLKRGDVELRFQEGQWKAYDAAKAHLSKGRKSEALAQLNDCIAEGRILENRYPDFKEQKFDIGGTSMSMLELLQACAKERKALQPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1N9</accession>
    <name>Q1D1N9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5282"/>
    <dbReference type="EnsemblBacteria" id="ABF86798">
        <property type="protein sequence ID" value="ABF86798"/>
        <property type="gene ID" value="MXAN_5282"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5282"/>
    <dbReference type="eggNOG" id="COG3425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2070583_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="118" mass="13072" checksum="C7362FD3B9F7A5E1" modified="2006-07-11" version="1">MTWRAMTADRPCPDIVPTPGPPPWTHFTSQRTRATTDGACATAAPASVLGQRSTPRPRVVASTTRGSRSRRERGSIEEYERLMKLRLDAPEAKAPAPGAFHMMEIRDHKRLYVEGDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y9</accession>
    <name>Q1D1Y9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
            <ecNumber evidence="6">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">MXAN_5181</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EC" id="3.4.16.4" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555152.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5181"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91607">
        <property type="protein sequence ID" value="ABF91607"/>
        <property type="gene ID" value="MXAN_5181"/>
    </dbReference>
    <dbReference type="GeneID" id="41362463"/>
    <dbReference type="KEGG" id="mxa:MXAN_5181"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_7"/>
    <dbReference type="OMA" id="ADWAGKT"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Transgly" evidence="19">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PCB_OB" evidence="20">
        <location>
            <begin position="400"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="18">
        <location>
            <begin position="487"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="802"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ABF91607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="832" mass="91489" checksum="411E8EF2AC2B232D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D244</accession>
    <name>Q1D244_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator MrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mrpC</name>
        <name evidence="4" type="ORF">MXAN_5125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002634092.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5125"/>
    <dbReference type="EnsemblBacteria" id="ABF91424">
        <property type="protein sequence ID" value="ABF91424"/>
        <property type="gene ID" value="MXAN_5125"/>
    </dbReference>
    <dbReference type="GeneID" id="41362409"/>
    <dbReference type="KEGG" id="mxa:MXAN_5125"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_1_7"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="248" mass="27279" checksum="D7E0DBCB9727C54D" modified="2006-07-11" version="1">MHGFNRPLGPIGSNVVAPLQTTSSGMMVTANKLVPGQEAIDFKGYFKVESFPHNSTIYRPGDNTDRVYLLKSGRVRLMRIGKNSTRSVVSILRPGDLFGELFRPEGTPIEEMAIAAGEAEVWSIEGRDFRAQLEARPALAVDVVRAYAERVRALRKRVLGLTFKEVPARLADTLLTLVEAHGERCPHGGETDLRGITQQDLADLVGASRSFVSTLINEMKREGVLGNVGRILCVRDQKALRKIAGKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D251</accession>
    <name>Q1D251_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555092.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5118"/>
    <dbReference type="EnsemblBacteria" id="ABF87309">
        <property type="protein sequence ID" value="ABF87309"/>
        <property type="gene ID" value="MXAN_5118"/>
    </dbReference>
    <dbReference type="GeneID" id="41362402"/>
    <dbReference type="KEGG" id="mxa:MXAN_5118"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620853_0_0_7"/>
    <dbReference type="OMA" id="CAVFRAD"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="57"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="441" mass="47032" checksum="30C490C5E6CE0258" modified="2006-07-11" version="1">MEGRLLLKNCAVFRADGRVRHGMAVVVEGNTIRRMAPDAQVPVLPGDWEVACHGRLVAPGLVDCHTHLVNGQLLPPTGHFLMLPPRERLDRLRHVARLLTNEDVEALTRYAAARALRHGVTLAVEHLSCQDVAGGLAAQARAAEAVGLRLVTSHSTHGLDGAAQAQAWLDANADFTRAHRDHPLVRGALGFHASFTCDDALLRRIAELSRVLDAPTVFHLAESEDDLSSTYSQHGKRVVPRLDALGLLGPRAIAGYARVLDSAEAELLEQSGAFVALAARGVRALERGADPMDAVLSRVHLLGLGTGGHGSLQDELLAALVGVLRISRSGRLPDVDGALAHLLVNGPAELCTRLFGLPSGSVEEGSIADLVVYDVVPTADPETGYSPYLLGQLAHSPVGWTIVNGRVCVREGQLLGLDYVALSRAATEALERVWTRARLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2J2</accession>
    <name>Q1D2J2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554953.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4975"/>
    <dbReference type="EnsemblBacteria" id="ABF91748">
        <property type="protein sequence ID" value="ABF91748"/>
        <property type="gene ID" value="MXAN_4975"/>
    </dbReference>
    <dbReference type="GeneID" id="41362260"/>
    <dbReference type="KEGG" id="mxa:MXAN_4975"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047246_0_0_7"/>
    <dbReference type="OMA" id="YLCETVL"/>
    <dbReference type="OrthoDB" id="687718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="419" mass="43760" checksum="D1EDB070CB3C12B1" modified="2006-07-11" version="1">MATALPQPSTYAGPEALAEAGARRHASRGRPRVLLVDSAPGAQAVLAAALAEAGFEVLLVAGAQAALASLAEGGTAPQLVVTEVELQDGDGFSLCGQVRADARTAHLPVLLLARREEEFHRDLAGGVGADDYLAHPVDARDVVALARLKAGQCSGDAAFASDTQRLPLTDVARALLAGVRSGRVVMAEGQGWFAFRHGLVVDAVFNGERGSLAFRRMLCFGAGDYAVTLGPELHKGSFTMDRPYLCETVLQGLERFDALRARGLPLASRLTVDFARLAEMLASLPEDVGEVVRLFDGRRTLRAMLLECQFPEAVAYEASTRLFALGILVPACLLEERERAHCGSTVPGFFEPAPSVDAEPVDAREPAPAACGGDGASAPFTLVGGSQPPVILDFPKKVPGASSGAEGLEGAVRSDDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D309</accession>
    <name>Q1D309_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DotU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554789.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4803"/>
    <dbReference type="EnsemblBacteria" id="ABF91558">
        <property type="protein sequence ID" value="ABF91558"/>
        <property type="gene ID" value="MXAN_4803"/>
    </dbReference>
    <dbReference type="GeneID" id="41362102"/>
    <dbReference type="KEGG" id="mxa:MXAN_4803"/>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071818_3_0_7"/>
    <dbReference type="OMA" id="REVYYLC"/>
    <dbReference type="OrthoDB" id="1650600at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DotU" evidence="2">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26690" checksum="2F8A31E04366F47F" modified="2006-07-11" version="1">MDRVTEATKDCFDAAIQLRGSEASAVPPPETLHHRLRGVVDETLRRAAVLGFSHQDAQDMAYALVALIDEVVLGRPEEYRQLWMPLQLHYFNENVAGDGFFARLNTVRKDPHRHEVLQVYYLCMLFGFQGRYRIRGGELELMTLIDTVQKDLERARPFDFDVLSPHGDRPTESLLSKRKKASMVSISAGALAVAVLFYGVLQFFLNDKVGELRSRIEVHAARNTATSASQTQATGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D0</accession>
    <name>Q1D3D0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4677"/>
    <dbReference type="EnsemblBacteria" id="ABF86868">
        <property type="protein sequence ID" value="ABF86868"/>
        <property type="gene ID" value="MXAN_4677"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4677"/>
    <dbReference type="HOGENOM" id="CLU_071555_0_0_7"/>
    <dbReference type="OMA" id="PIGNSEM"/>
    <dbReference type="OrthoDB" id="1564767at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="35052" checksum="205AF119C2048EA7" modified="2006-07-11" version="1">MRAAHGAGLGQFPAKIQGLGREGFDTQGRRSEDDTWILSAGALVLNCPGCGSKVAANTSICSVCDYIIDGSFLSGEPPAEESEESTDAAEDPRRAAKPPPPRRPRPAAGKSGSRPAAAPPPDSDSTNIRSMEDVARSAPQQRAARAAAPRPAPRKAPAPEPAASVDPWDRSDSHDRGTAVTDPDELIRDAKELFAQLQGGDKVAFWGAAVVLMSCFMPWKETAVDGDVLGLMSLGSGAFIMSILLLTAVTVRVKGSFPNVNPVVPWMGQLIVSIVCLIWCVVFIKVSSDTTMVPTPIGNSEMMNSSPSFGVYVAILGAVATMGGTLLGLKGQSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q9</accession>
    <name>Q1D3Q9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554541.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4546"/>
    <dbReference type="EnsemblBacteria" id="ABF87791">
        <property type="protein sequence ID" value="ABF87791"/>
        <property type="gene ID" value="MXAN_4546"/>
    </dbReference>
    <dbReference type="GeneID" id="41361847"/>
    <dbReference type="KEGG" id="mxa:MXAN_4546"/>
    <dbReference type="eggNOG" id="ENOG5032VPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156570_0_0_7"/>
    <dbReference type="OMA" id="YFGRCLG"/>
    <dbReference type="OrthoDB" id="1661311at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="148" mass="16300" checksum="3151BE86743CF355" modified="2006-07-11" version="1">MRGPPRQGGPRRLECAIMISPDHPLASWFLIIAGTLFLVVFAIPLLLMPLTWARWFGWRLPEGNNHLTVYFGRCLGAVALAIILTAARFVSRPGPAIFDLIGWVCAGMVVVHTWGALKKAQPVSETVEIGFYAVVGVLAMWIRFNALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4E7</accession>
    <name>Q1D4E7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4301"/>
    <dbReference type="EnsemblBacteria" id="ABF87427">
        <property type="protein sequence ID" value="ABF87427"/>
        <property type="gene ID" value="MXAN_4301"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4301"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_16_2_7"/>
    <dbReference type="OMA" id="MLNDKDF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="634"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="761" mass="81650" checksum="67C0701483D481AC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4G0</accession>
    <name>Q1D4G0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4288"/>
    <dbReference type="EnsemblBacteria" id="ABF91777">
        <property type="protein sequence ID" value="ABF91777"/>
        <property type="gene ID" value="MXAN_4288"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4288"/>
    <dbReference type="HOGENOM" id="CLU_3120166_0_0_7"/>
    <dbReference type="OMA" id="VKLMNVM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="50" mass="5592" checksum="DB0416A9AF60A058" modified="2006-07-11" version="1">MTKTKAKAPQSSKQTKQKLVKLMNVMEKATVPAATTAMNLTCRRIYCSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4N7</accession>
    <name>Q1D4N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554214.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4211"/>
    <dbReference type="EnsemblBacteria" id="ABF91620">
        <property type="protein sequence ID" value="ABF91620"/>
        <property type="gene ID" value="MXAN_4211"/>
    </dbReference>
    <dbReference type="GeneID" id="41361528"/>
    <dbReference type="KEGG" id="mxa:MXAN_4211"/>
    <dbReference type="HOGENOM" id="CLU_601171_0_0_7"/>
    <dbReference type="OMA" id="FFTPRNP"/>
    <dbReference type="OrthoDB" id="583932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="459" mass="48058" checksum="CCD8A1ABCDD050D2" modified="2006-07-11" version="1">MAKPKSGAKKTTPAGKAGAKPAAKKDSAARLDLIKNASKRAAKAATKLAKAASDVTKGAKSAVKKAVQEKATAKKAAPAGKTASAAKAAPPAAKTPKAPPAKAPPAAKSAASAKAAKASAVPAAPPVEKPRPRATKLPPPGEPLTKREMEQLLTAGEGRGVTGEGSLKGRLVVTNDMPHLVVVGRDKRELTFLLQGPDQEVLPAYVDHKVSVSGLIRKTTNHAGVVDVRKYSAKKPDAEVVEAAPAETEARLRYLSPGEVSMVTAAGMGAGIKGFAGVRGNLEMTGEEFVLVVSNGGTRQQVSFIIEGKAAGKALRKHVGYTLQVQGVVDKTSGWGGRIMAENVELRPSEARAVSRDEMELVHIEGEVPTSVDVRLNHGLTVRLPEHPGFTWAIEPTVAKRVGLREANFEPAPEDGPGTREFFFTPRNPGAFDVEFFLAKALSPGLVDRSFKINVTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4W7</accession>
    <name>Q1D4W7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4131"/>
    <dbReference type="EnsemblBacteria" id="ABF92547">
        <property type="protein sequence ID" value="ABF92547"/>
        <property type="gene ID" value="MXAN_4131"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4131"/>
    <dbReference type="eggNOG" id="ENOG502ZADJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046244_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="438" mass="50975" checksum="872B3D91612C1F07" modified="2006-07-11" version="1">MAVFRQIVQCEFCAATTLIRIQIGYLEQHPIRVPCGSCGVLISATAFVSQSKPKFWVDYRNAKLVDDESGDFYIEASPEFLTEKLQKLDRRAPPLDFSPFIKAFAVMGDKGYEEFGRNIQRFSHILKTSWPQIQRINQLWLSRALPQLAREILTMQARLEFLAPNQLSISNELQSLMAVHRLNLLFISPIRNPERFEEITKLIFKALKKFSAAQIADLMDFGEMLNQRGYLQQLEEKFLCLTELFVERFRFLIPVFGLRYYQSRDPDLLERKGVTTTSFEDLKQLFLFSHEIISESLTLIVGWNNVRNRGGWSRMAPRREDVQTLSQYEDKSLDARAQYLDGSEVFDRLLHNYWDEPLCSSIAHGFHKYEGVEQRVIYYAGGLKDEANKRSVFLVEFTHRCLELFLAAQDVAELLYQTQKLVFGRQGQQSIPPPIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D539</accession>
    <name>Q1D539_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554063.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4056"/>
    <dbReference type="EnsemblBacteria" id="ABF91035">
        <property type="protein sequence ID" value="ABF91035"/>
        <property type="gene ID" value="MXAN_4056"/>
    </dbReference>
    <dbReference type="GeneID" id="41361386"/>
    <dbReference type="KEGG" id="mxa:MXAN_4056"/>
    <dbReference type="HOGENOM" id="CLU_911251_0_0_7"/>
    <dbReference type="OMA" id="TEPNPIN"/>
    <dbReference type="OrthoDB" id="1064439at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="34280" checksum="40FEE4E2E4C7A20E" modified="2006-07-11" version="1">MGVGNHGILARKMAAGQDLAADVDGLWLFKHGDLVLGPVSGAQLVEKLTSGELTLDTLVAPAGERDFHRMSEVDAFRVHVARAEARARVDAAVVVERAKSAKRLKILGGAAAAGVVVLGIVGIQVARNAAVHGWFGGGEVQTDDFEMGEITIRVAQARVDDEELFEYPGHGARRPGSGEPGVKPATGSSGPGKVAMASTTRAPADRKPRPGGSVTTDPDGMETTQQFDQSAINQVVASNKSTLFRCFKEEAERTPGIYAKVPMEFVIGNNGRVSKLWVDNHQFKKGPLYECLLSEMQKWPFRAYEGEQATVGLSFTIGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D548</accession>
    <name>Q1D548_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_PrkA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554054.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4046"/>
    <dbReference type="EnsemblBacteria" id="ABF92304">
        <property type="protein sequence ID" value="ABF92304"/>
        <property type="gene ID" value="MXAN_4046"/>
    </dbReference>
    <dbReference type="GeneID" id="41361377"/>
    <dbReference type="KEGG" id="mxa:MXAN_4046"/>
    <dbReference type="eggNOG" id="COG2766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367970_0_0_7"/>
    <dbReference type="OMA" id="PRVLHNF"/>
    <dbReference type="OrthoDB" id="49410at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="748" mass="85184" checksum="06E92B41BCB6BAC0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A2</accession>
    <name>Q1D5A2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein RecA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554001.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3991"/>
    <dbReference type="EnsemblBacteria" id="ABF92318">
        <property type="protein sequence ID" value="ABF92318"/>
        <property type="gene ID" value="MXAN_3991"/>
    </dbReference>
    <dbReference type="GeneID" id="41361323"/>
    <dbReference type="KEGG" id="mxa:MXAN_3991"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959177_0_0_7"/>
    <dbReference type="OMA" id="CAWVDGP"/>
    <dbReference type="OrthoDB" id="1169082at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="30274" checksum="FCD932086AEAF151" modified="2006-07-11" version="1">MSAAEQRVGAGQGTGSVVEQLRERIRQLQAAPRRYLAVLRTGLSAVDALLPTGGLPLGQVVELCGEAASGRTSLALHAVAAAHQEARLCAWVDGPRELYSPSAAALGVDLERLLIVRPQASEQRIWAAVQLARSGAFACVVLDLTRGMNPGGRACRVALAEARKLADAAARGGGLLLLLTSPESPADGVVRLRTEARDGDGWSVEVVRSRQGGTGARAELPWSALYPALGLEGGGRLLDVAEDTEDGTPDFLRDQSGALRNGLGILGQRPGRDAPMPPMRQGLDAALPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L5</accession>
    <name>Q1D5L5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DIOX_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553888.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91438">
        <property type="protein sequence ID" value="ABF91438"/>
        <property type="gene ID" value="MXAN_3878"/>
    </dbReference>
    <dbReference type="GeneID" id="41361211"/>
    <dbReference type="KEGG" id="mxa:MXAN_3878"/>
    <dbReference type="eggNOG" id="COG3491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713122_0_0_7"/>
    <dbReference type="OMA" id="DFKECYF"/>
    <dbReference type="OrthoDB" id="400496at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIOX_N" evidence="2">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="43984" checksum="934AB50164613E0F" modified="2006-07-11" version="1">MPAPGIRVLPRPTGPGRTPQSNRASHLFPRSGTPGPIMAETSSLNIPTVDLADLASDDSARVERAAAAIREAFGVFGLVYLKNHGVDTQALNRFYDAFAAFIARPAEEKKPYGRADIWYQRGWTPPNTEVAVASNGQPDFKECYFVAPYPNDAQSALEFPELYPENVWPQNAPPYFEDGIMTLGRSLHEAGLKLLRGSAVALGLPETLFTDLCDRAAHVTRALQYLPLTNTQVNTDIVWGEEHTDFNLLTLLPGGRFLDPDGSPAPGPDNKSGLYLRTRATPEAPNGLKVRGTAPAGCIVAQVGQQLEILTGGTFLATPHVITAPGVPGWQRQSAAHFMHVHTNTVLFPLEKFRSADAVRNYAPPVLAGTYDIKTLVDIGLAPASALDKLGYRHYDRLNRQRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5N3</accession>
    <name>Q1D5N3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone/plastoquinone oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553870.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3860"/>
    <dbReference type="EnsemblBacteria" id="ABF87324">
        <property type="protein sequence ID" value="ABF87324"/>
        <property type="gene ID" value="MXAN_3860"/>
    </dbReference>
    <dbReference type="GeneID" id="41361193"/>
    <dbReference type="KEGG" id="mxa:MXAN_3860"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_3_1_7"/>
    <dbReference type="OMA" id="AIYMMLR"/>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="12773" checksum="B25E83F1B87BECA9" modified="2006-07-11" version="1">MELFLAITVGGLFAAGFYCLMLHSIVRIALGLVLLGSATNLLIFTINGLQRGFAPLVPEGQEALTPPFADPVPQAFILTAIVINFGLLALLLVLVHRAAQETGTDDTRALRTELKDSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V2</accession>
    <name>Q1D5V2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacid CoA-transferase family, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553802.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3789"/>
    <dbReference type="EnsemblBacteria" id="ABF85900">
        <property type="protein sequence ID" value="ABF85900"/>
        <property type="gene ID" value="MXAN_3789"/>
    </dbReference>
    <dbReference type="GeneID" id="41361121"/>
    <dbReference type="KEGG" id="mxa:MXAN_3789"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_7"/>
    <dbReference type="OMA" id="AFEVDTQ"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="23405" checksum="47DC3F335B321722" modified="2006-07-11" version="1">MPLTREQIAQRIAQELQDGFYVNLGIGMPTLVANYIPPGMDIVLQSENGLLGIGPWPVEGQEDPDLINAGKETVTAVPGAAFFDSALSFGMIRGGHIDMAVLGAMEVSEEGDLANWMIPGKMIKGMGGAMDLAVGAQRIFVAMEHANKDGKPKILKKCSLPLTGLKCIHHIVTDHAYIDVTPQGLILREVAPGVTVEQVQKLTEPKLTVAPDVREMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6I8</accession>
    <name>Q1D6I8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ORF">MXAN_3542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553571.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3542"/>
    <dbReference type="EnsemblBacteria" id="ABF91257">
        <property type="protein sequence ID" value="ABF91257"/>
        <property type="gene ID" value="MXAN_3542"/>
    </dbReference>
    <dbReference type="GeneID" id="41360887"/>
    <dbReference type="KEGG" id="mxa:MXAN_3542"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_7"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="30621" checksum="79847FDD41D372DA" modified="2006-07-11" version="1">MAILVNENTKVLCQGITGSAGSFHAKQMLEYGTKLVAGVTPGKGGTTFEGKVPVFNTVAEAVKETGANTSVVFVPPPFAADSIMEAADAGVALIIVITEGIPVNDMVRAKRYLQGKPGIRLVGPNCPGVITPGALCKIGIMPGHIHKPGRIGVVSRSGTLTYEAVHQLTQLGLGQSTAVGIGGDPVNGTDFVDVLKLFNADPDTDAVIMIGEIGGDAEERGAEYVAREFTKPIAGFIAGQSAPPGKRMGHAGAIISGGKGTATEKIKAMEAAGILMAASPAELGTTLQEALKRGAPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S8</accession>
    <name>Q1D6S8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553481.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3448"/>
    <dbReference type="TCDB" id="2.A.6.1.9">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85925">
        <property type="protein sequence ID" value="ABF85925"/>
        <property type="gene ID" value="MXAN_3448"/>
    </dbReference>
    <dbReference type="GeneID" id="41360796"/>
    <dbReference type="KEGG" id="mxa:MXAN_3448"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724891_0_0_7"/>
    <dbReference type="OMA" id="SARTPWV"/>
    <dbReference type="OrthoDB" id="1319738at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188272" evidence="1">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="37889" checksum="D27534648AFA83CA" modified="2006-07-11" version="1">MTPFVRRFVAVPMLALSGACTSGSSTAEVPPAPPPARASAPSAWVPVRAASRVALAEAPALVLSSPDAVAALSAPFRARVQQVRARPGQQVKAGDPLVEVLMPEVVEAAGAASAASLRLEAYSRQVERLEALHAQGLAKLPDLADAQTQQAEARAALVAAHAVLRVAGIAPGEARGVAERGTVWLKSPIGGIVTEVRAVLGEMQPEASAALVRVAADGPARLEARLSVRPPEDASFAFVSSQGIAVPVRWVGQSPVVDAADGTWRAWFEPEDTAAVLRAGQGGRLRIQAAAGEDTVLVPARALAFDSARTVVFTRGGEGQPVRREVEVLATSGAEALVKGPLSARDTVAADGAALLLESQAGDADEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6T3</accession>
    <name>Q1D6T3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553476.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3443"/>
    <dbReference type="EnsemblBacteria" id="ABF88476">
        <property type="protein sequence ID" value="ABF88476"/>
        <property type="gene ID" value="MXAN_3443"/>
    </dbReference>
    <dbReference type="GeneID" id="41360791"/>
    <dbReference type="KEGG" id="mxa:MXAN_3443"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_45_3_7"/>
    <dbReference type="OMA" id="RAHFARD"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="216" mass="24315" checksum="520DE651DCE40454" modified="2006-07-11" version="1">MPRPRASRLDPERRQTLLAVAAEEFAEHGFDGASYNRILERAGFSKGVAYYYFEGKDDLYAAVLALTLDTLAQRFGAWHRPADADGFWRTLRERYFALTTHIVNDERSARLLRSMSQARTHPKLQAAWLRFEGPLVAWFQRVLADGRALGAVRGDVPESLLLTSLMGIGQVTDGWLLEQWAHSGVPALQRGAEQVFSLFEDLLVPRPVGPPPAKRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-10" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D749</accession>
    <name>RS4A_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4 A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD1</name>
        <name type="ordered locus">MXAN_3325</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553360.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D749"/>
    <dbReference type="SMR" id="Q1D749"/>
    <dbReference type="STRING" id="246197.MXAN_3325"/>
    <dbReference type="EnsemblBacteria" id="ABF87729">
        <property type="protein sequence ID" value="ABF87729"/>
        <property type="gene ID" value="MXAN_3325"/>
    </dbReference>
    <dbReference type="GeneID" id="41360678"/>
    <dbReference type="KEGG" id="mxa:MXAN_3325"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_7"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000293321" description="30S ribosomal protein S4 A">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="208" mass="23936" checksum="D52A5344F69C56B8" modified="2006-07-11" version="1">MARYTASACRICRRENLKMYLKGDRCYTDKCAIERRPYPPGQHGQGRVKFSGYGVQLREKQKVKRMYGLLENQFRGYYHRASAAKGKTGDNLLQQLELRLDNVVFRMGFADTRNEARQLVRHGHFQVNGRKVNIPSFAVKPGTAVEVVEKSRKVLRISEALETVDRRGIPQWISLDKKAFKGTVTTVPNREDLTMPISEQLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D3</accession>
    <name>Q1D7D3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553286.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3241"/>
    <dbReference type="EnsemblBacteria" id="ABF86283">
        <property type="protein sequence ID" value="ABF86283"/>
        <property type="gene ID" value="MXAN_3241"/>
    </dbReference>
    <dbReference type="GeneID" id="41364663"/>
    <dbReference type="KEGG" id="mxa:MXAN_3241"/>
    <dbReference type="eggNOG" id="COG5507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169953_0_0_7"/>
    <dbReference type="OMA" id="RMIVGGF"/>
    <dbReference type="OrthoDB" id="1360518at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009874">
        <property type="entry name" value="DUF1428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07237">
        <property type="entry name" value="DUF1428"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26436" checksum="BFF60ED8B84C5D86" modified="2006-07-11" version="1">MAYIDGFVIAVPSANKEAYRQAAIAAAPLYKEFGATRFVENWGDDVPEGKVTDLRRAVKAEPDEVIVFSWIEYPSKAVRDEANAKAMRDPRMQAMGANISFDGKRMIFGGFVPSLHEGGAGRPGYVDGSLVPVPVGNKEAYHVIASRLAAVLLEHGATRVVDAWGDDVPDGKVTDFKGAVKATADEQVVFAWIEWPSKEARNAGWGKAMADPRMHPGSMPFDEGRRSHGGFVPMLVETAATDTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D4</accession>
    <name>Q1D7D4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3240"/>
    <dbReference type="EnsemblBacteria" id="ABF90707">
        <property type="protein sequence ID" value="ABF90707"/>
        <property type="gene ID" value="MXAN_3240"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3240"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_35_2_7"/>
    <dbReference type="OMA" id="GVSRHYD"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="17122" checksum="DEF39162E083988E" modified="2006-07-11" version="1">MISTQLPLSMSRAVPFATTLHVRDHCLCLVVQQAARALARRFDEALRPVGLTHGQFSLLMSLNRPQPPSIGPVAELLAMDRTTLTANLKPLERRGLVKTTVDPADRRGRLLTLTDAGLQLLQSALPHWEKMNEETERLLAQTDVDALRAGLRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D5</accession>
    <name>Q1D7D5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P4Hc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3239"/>
    <dbReference type="EnsemblBacteria" id="ABF89369">
        <property type="protein sequence ID" value="ABF89369"/>
        <property type="gene ID" value="MXAN_3239"/>
    </dbReference>
    <dbReference type="GeneID" id="41360593"/>
    <dbReference type="KEGG" id="mxa:MXAN_3239"/>
    <dbReference type="eggNOG" id="COG3751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078769_1_0_7"/>
    <dbReference type="OMA" id="FNRCVIF"/>
    <dbReference type="OrthoDB" id="1139586at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P4Hc" evidence="4">
        <location>
            <begin position="40"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="27697" checksum="F83A38FC47BAFCC0" modified="2006-07-11" version="1">MSIATHEEGPLRGPSFFFSRTALRSLALAHRASYGAARPHPHAVIDGFLGGPLASELAAVFPGATEASWKRRDHPEQAARLGQLQRKAFEDVPGALRHLLSEFSGMAFIDFLESLTGVQGLIPDPHFRGAGLHLTLRGGHLALHADFNRDRFRALSRRLTVLYYLNPGWEPAWGGDLELWSSDLSRCETRIAPLLDRLVVMAHGDDHWHGHPTALECPEGRGRAAVAAYFYTAEEAPNAPEPHSAIWAPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7N8</accession>
    <name>Q1D7N8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3132"/>
    <dbReference type="EnsemblBacteria" id="ABF92594">
        <property type="protein sequence ID" value="ABF92594"/>
        <property type="gene ID" value="MXAN_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3132"/>
    <dbReference type="eggNOG" id="COG2974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105386_0_0_7"/>
    <dbReference type="OMA" id="WLLWRSE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="229" mass="25222" checksum="3180B50ABF53F182" modified="2006-07-11" version="1">MARRDEARAEAAFMRGDVGVDGGATEETKDEAEVEKGKAQDQLLRGRAYLGREFLTWLLWRTEAGGPLVEVEGEGVSVLFMGRVVLRGVSGEVTEMSAKGTLAPYSEQVKHSLDRGLLVAQARLRFTQGEREFEATVDSEFLDIRAGKLPALMSEEEDDQLSERLLLMEQLAAMVDALVQDYLSVRASKGWSKTVVPAMKEWMRGDEQGADALAKAARARGRDARTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7V4</accession>
    <name>Q1D7V4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-L-glutamate ligases, RimK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_3061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553116.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3061"/>
    <dbReference type="EnsemblBacteria" id="ABF91604">
        <property type="protein sequence ID" value="ABF91604"/>
        <property type="gene ID" value="MXAN_3061"/>
    </dbReference>
    <dbReference type="GeneID" id="41360423"/>
    <dbReference type="KEGG" id="mxa:MXAN_3061"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_0_1_7"/>
    <dbReference type="OMA" id="TRGHQGK"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041107">
        <property type="entry name" value="Rimk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18030">
        <property type="entry name" value="Rimk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="104"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="333" mass="35391" checksum="256EF8ACC2CE8EB8" modified="2006-07-11" version="1">MKATILSRSASIPSTRRLVEVARARGHRVRVLNPLRVQMHLDGRSATLYYGRKKLAPTDVVLPRIAQSISNYGLAVVNQFGLARVSLVNHAQAIAQSRNKMRSLQLLSAHGIDIPSTVMARDAAHLKEMVGLLGGVPVLVKLLQGQEKHGVMVCESLQSLEAALEAVLGLGHNLVMQEYVKSTGIDVRVLVVGGQAVAAVRRRPRPGRLAHTLIKGARLEAHELSPAQRATAEKATRLIGLEVAAVDLLDVQGQPKIFEVNSSPALPEMEAVTGVDLASLIIIRAEALVAGEPPVSVPDLSPPSALPASSEPAQLPVDRKGTGRRARTGEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D803</accession>
    <name>Q1D803_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553067.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3011"/>
    <dbReference type="EnsemblBacteria" id="ABF88844">
        <property type="protein sequence ID" value="ABF88844"/>
        <property type="gene ID" value="MXAN_3011"/>
    </dbReference>
    <dbReference type="GeneID" id="41360372"/>
    <dbReference type="KEGG" id="mxa:MXAN_3011"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_6_1_7"/>
    <dbReference type="OMA" id="IHWQSLV"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="305"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="606" mass="63903" checksum="3D2B7EA53D4B95D3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8A1</accession>
    <name>Q1D8A1_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Serine/threonine kinase PKN11</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pkn11</name>
        <name evidence="3" type="ORF">MXAN_2911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF85967">
        <property type="protein sequence ID" value="ABF85967"/>
        <property type="gene ID" value="MXAN_2911"/>
    </dbReference>
    <dbReference type="GeneID" id="41360279"/>
    <dbReference type="KEGG" id="mxa:MXAN_2911"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_000288_151_5_7"/>
    <dbReference type="OMA" id="DKHEDTY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="393"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="791" mass="81669" checksum="DBCDF5B34C49D35F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I4</accession>
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        <submittedName>
            <fullName evidence="3">Transposase, IS66 family, truncated</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_2828</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2828"/>
    <dbReference type="EnsemblBacteria" id="ABF86801">
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        <property type="gene ID" value="MXAN_2828"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="2">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="20419" checksum="31E844DD8D1CE403" modified="2006-07-11" version="1">MFALPASVRVVLATGPVDMRKSIDGLMSLVRTAAHRELRQLHSAPVLTQLHVWLETQAPRHLPKSPLGQAISYALKQWEALTRFIENERLPLDNNRAEAALRKAALSRKNFLFVGHEAAGENLEGLYALVATCAANGVNPETYLTDVLLRAQTHPNSRIGELLPHEWKCRRVAEPPDSVLQPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q2</accession>
    <name>Q1D8Q2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase, M4 (Thermolysin) family</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_2754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552821.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2754"/>
    <dbReference type="EnsemblBacteria" id="ABF91389">
        <property type="protein sequence ID" value="ABF91389"/>
        <property type="gene ID" value="MXAN_2754"/>
    </dbReference>
    <dbReference type="GeneID" id="41360131"/>
    <dbReference type="KEGG" id="mxa:MXAN_2754"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008590_5_2_7"/>
    <dbReference type="OMA" id="KMSYGDG"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="P/Homo B" evidence="10">
        <location>
            <begin position="269"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="725" mass="77861" checksum="931E5AB75A850981" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D9</accession>
    <name>Q1D9D9_MYXXD</name>
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        <submittedName>
            <fullName evidence="8">General secretion pathway protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gspC</name>
        <name evidence="8" type="ORF">MXAN_2515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF87304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2515"/>
    <dbReference type="EnsemblBacteria" id="ABF87304">
        <property type="protein sequence ID" value="ABF87304"/>
        <property type="gene ID" value="MXAN_2515"/>
    </dbReference>
    <dbReference type="GeneID" id="41359892"/>
    <dbReference type="KEGG" id="mxa:MXAN_2515"/>
    <dbReference type="eggNOG" id="COG3031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080704_0_0_7"/>
    <dbReference type="OMA" id="LKGQSRI"/>
    <dbReference type="OrthoDB" id="1597080at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024961">
        <property type="entry name" value="T2SS_GspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11356">
        <property type="entry name" value="T2SSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSC" evidence="7">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="34170" checksum="E51465949104DAD3" modified="2006-07-11" version="1">MRARLSPGSVMELFFRKYFWTVNLVFILLVGLLAASTVNLFVESAISPVPTGGSSARAPSQPRRIETAMAMLDLDRLSRLTGIKLPEPEPEVQEPGGASAEVDPNAAPVKSGLRVKLLGTLVASNPDWSFASIQDMTTQRSQTYMVGNSLQGATVENIERERVIIINGGRREYIDGNPGDGAFVPPSPPVAQANTAPPSDGSGIRATSENEYEVPRAEIDKTLNNLNNVAMQARIVPAFKDGQAVGFKLFSIRPDSIYSKIGVQNGDVIRRINGFDLNSPEKALEVYSKMKDAARIEIEIERNGAPIRKSYNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I6</accession>
    <name>Q1D9I6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2467"/>
    <dbReference type="EnsemblBacteria" id="ABF87802">
        <property type="protein sequence ID" value="ABF87802"/>
        <property type="gene ID" value="MXAN_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2467"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054176_1_0_7"/>
    <dbReference type="OMA" id="DMLPFGY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="29564" checksum="625ACC685B31897E" modified="2006-07-11" version="1">MSVTTATDTLLDGTHTVLTPEYVEFRFTLAGLYSRFLAWLLDAVIVTLLTGTILTTLSLVMFAFPGFASALSIVIYFLVDWGYAITLETVWSGRTVGKRVMSLRVIQESGVRIGFYHAALRNLARPVDRLPLFYLVGGLTALVSGSQQRLGDMLAGTLVVRERRLKVPSALGMPGDEGLLADPLFVSRVKRLSSEEREVVLTAALRREELRMEARLRLFAALGARLQDALAMEKPPHLSDEKWALLVAAALLPPKGQPRSTPQRRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9P6</accession>
    <name>Q1D9P6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552482.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D9P6"/>
    <dbReference type="STRING" id="246197.MXAN_2407"/>
    <dbReference type="EnsemblBacteria" id="ABF86014">
        <property type="protein sequence ID" value="ABF86014"/>
        <property type="gene ID" value="MXAN_2407"/>
    </dbReference>
    <dbReference type="GeneID" id="41359791"/>
    <dbReference type="KEGG" id="mxa:MXAN_2407"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="323"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="577"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="642" mass="70617" checksum="924B92AFE0410E11" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9U7</accession>
    <name>Q1D9U7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552431.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2356"/>
    <dbReference type="EnsemblBacteria" id="ABF93146">
        <property type="protein sequence ID" value="ABF93146"/>
        <property type="gene ID" value="MXAN_2356"/>
    </dbReference>
    <dbReference type="GeneID" id="41359740"/>
    <dbReference type="KEGG" id="mxa:MXAN_2356"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062591_0_0_7"/>
    <dbReference type="OMA" id="FRHGGFE"/>
    <dbReference type="OrthoDB" id="1244860at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="30284" checksum="CBDDF96849413B2F" modified="2006-07-11" version="1">MPPLDTKTRGRTSRGRLRALDAFLCRFERPLLERRDGPWAHAVFVDVGFGEHPWTTLESAQAFRALNPELAVVGVELDAERARAAQADADARTSFREGGFALPLRPDEPARLVRAMNLLRQGAPERVPEVHRTLTRYLLPSGLLVEGSADATGAVMAAHLLRRGVGEGAELPLREALLFHTDFSLGFAPMLFRDWLPRDLRRRVRPGEPIHDFFSAWSAAWQQARTLGHTHPPDAFREAALGLSARMEGVATDPWLLSQGYVVWRPKGGVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W7</accession>
    <name>Q1D9W7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysN</name>
        <name evidence="8" type="ORF">MXAN_2336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552411.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2336"/>
    <dbReference type="EnsemblBacteria" id="ABF89446">
        <property type="protein sequence ID" value="ABF89446"/>
        <property type="gene ID" value="MXAN_2336"/>
    </dbReference>
    <dbReference type="GeneID" id="41359722"/>
    <dbReference type="KEGG" id="mxa:MXAN_2336"/>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_5_2_7"/>
    <dbReference type="OMA" id="FPVQYVL"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="15"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="570" mass="62095" checksum="F1E2E66640602ED9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y7</accession>
    <name>Q1D9Y7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF hand domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Might have a role in establishing the nucleoid structure of elementary bodies.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H1/H5 family. HCT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552391.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2316"/>
    <dbReference type="EnsemblBacteria" id="ABF90216">
        <property type="protein sequence ID" value="ABF90216"/>
        <property type="gene ID" value="MXAN_2316"/>
    </dbReference>
    <dbReference type="GeneID" id="41359703"/>
    <dbReference type="KEGG" id="mxa:MXAN_2316"/>
    <dbReference type="eggNOG" id="COG5126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347705_0_0_7"/>
    <dbReference type="OMA" id="NEFKAWW"/>
    <dbReference type="OrthoDB" id="1809211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009970">
        <property type="entry name" value="HC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07382">
        <property type="entry name" value="HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="24411" checksum="676EB045B9672344" modified="2006-07-11" version="1">MGWGACRCLDPNEGALRCAPSREGFIMATKSRKTAVAKKSSRRTATAKKATPKKAAGKAHGAKKTTTKKKTTAKKTTAKKAAAKKAPAKKTTAKKAAAKKTTAKKATTRKAATRRTSKSRRERPTTGVPFVEQVETTSAGLQPLAPTHAAVDEFTSSGDEVLDIFQRYDRDRTGTIDRAEFARLLEALGQNISDEELEIAVDIVDTDRTGKISWNEFKAWWNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA46</accession>
    <name>Q1DA46_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552332.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2256"/>
    <dbReference type="EnsemblBacteria" id="ABF86132">
        <property type="protein sequence ID" value="ABF86132"/>
        <property type="gene ID" value="MXAN_2256"/>
    </dbReference>
    <dbReference type="GeneID" id="41359644"/>
    <dbReference type="KEGG" id="mxa:MXAN_2256"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020670_0_0_7"/>
    <dbReference type="OMA" id="TTERMHE"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="765" mass="85302" checksum="634B4262C1A116A3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA91</accession>
    <name>Q1DA91_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome c nitrite reductase, small subunit NrfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2210"/>
    <dbReference type="EnsemblBacteria" id="ABF87584">
        <property type="protein sequence ID" value="ABF87584"/>
        <property type="gene ID" value="MXAN_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2210"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096753_0_2_7"/>
    <dbReference type="OMA" id="ACINCHV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017571">
        <property type="entry name" value="NrfH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03153">
        <property type="entry name" value="cytochr_NrfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_NNT" evidence="3">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17683" checksum="F550860468C95464" modified="2006-07-11" version="1">MSSASRTLLAVALGLALGSAIGIGGYTFAYAKGAAYLHDDPAACANCHIMTEQYDGWRKSSHHAVATCNDCHTPAALVPKYLNKASNGFWHSFYFTTGTFPDPIRIRPANRQVTESACRNCHASLVESIETPHADSLQCLTCHNSVGHPEGSGNPELIHQEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAE7</accession>
    <name>Q1DAE7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2153"/>
    <dbReference type="EnsemblBacteria" id="ABF89624">
        <property type="protein sequence ID" value="ABF89624"/>
        <property type="gene ID" value="MXAN_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2153"/>
    <dbReference type="eggNOG" id="COG4581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2826621_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="66" mass="7392" checksum="0905BC0580CED326" modified="2006-07-11" version="1">MRSSPPPLNRPSILPMLQVCRIPDFRKGLFGQQVALLRETFLQLTEGGGKRDAVWLNKQVAPFGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAF9</accession>
    <name>Q1DAF9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protease / nuclease, EndA/NucM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EndA/NucM nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2141"/>
    <dbReference type="EnsemblBacteria" id="ABF92402">
        <property type="protein sequence ID" value="ABF92402"/>
        <property type="gene ID" value="MXAN_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2141"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022603_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="794" mass="87820" checksum="F2EE629A537E0E1B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAL9</accession>
    <name>Q1DAL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23 peptidase domain protein</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552159.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2075"/>
    <dbReference type="EnsemblBacteria" id="ABF88579">
        <property type="protein sequence ID" value="ABF88579"/>
        <property type="gene ID" value="MXAN_2075"/>
    </dbReference>
    <dbReference type="GeneID" id="41359483"/>
    <dbReference type="KEGG" id="mxa:MXAN_2075"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825913_0_0_7"/>
    <dbReference type="OMA" id="AYCHNSE"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="228"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="35655" checksum="74BED51AB0906ADF" modified="2006-07-11" version="1">MAMFPRQAKGLLDFCMATLCLWAAYHHTPAGALVRKATAWATGTRSSARPLLAYYDGVSGTSLSPPLMAPDVPLSRALTDAEALAWGTHLALKGAQVRARQPALELAAELGVPAASLLDPQTGPAAARSLHTALSKDFPGEEARLTALFAGRVPARYALERVEAEGGAPTLERLSGQLPPGFEDASVGAAQALALATAFGLAWPVHESARVTSPFGDRFHPVLGRRKMHTGVDLGVPVGTPVVAVADGVVRRASEDAVNGRVLVVDHGRGVTTAYCHNSELLVKVGQRVRRGERVAHSGNTGRSTGPHLHYQLELAARPMDPLKFRTALRPVAKDPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAV7</accession>
    <name>Q1DAV7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552071.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1981"/>
    <dbReference type="EnsemblBacteria" id="ABF88944">
        <property type="protein sequence ID" value="ABF88944"/>
        <property type="gene ID" value="MXAN_1981"/>
    </dbReference>
    <dbReference type="GeneID" id="41359392"/>
    <dbReference type="KEGG" id="mxa:MXAN_1981"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566085_0_0_7"/>
    <dbReference type="OMA" id="DDHRPRW"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="497" mass="51491" checksum="C1940FB0AE5A8044" modified="2006-07-11" version="1">MTKRVVISALCGVLLVLSTGCGDECVDVFDCRSDKGPPPAGKDWTCRSGNCELRDVQRPPEGDAGTEEDAGTEGDAGTEQDAGTEEDAGTDAGTADGGGVVVIGTGAKGDACTSSADCAAGLRCEGTTEAMTCQALHVAFTAMDDTDEMAAVVTRFDAPEPTRLSDAEENSLYPRWNPAGNRIAFVQGATETGTSTGNLAGELVARDVPLVAGAPTMLANGTTGSTEGFLYLEWEPGDSLLYVRRAGDSISGISRVPAEGGTVEQVTALGSSPAWRNGNTFAFSTATVGISTATVGGAPTPLAIAGTTAEQPHYNRVNDQLLFLRPDDTRPVGLNAALYIVPVRGAAVQTIAEFTTAAVEGGSVDSYIANPTWAPDGSWVAYVRAYFFNPTTGEPELCGAGDSPCAGDPGNIIFLRRINPADGTPVGDEVSFAEGATLPSFSPDGHYVAYIQTGQLYVQQIDPAAGAKVGDPIVHPLGGYTLQTSRGDDHRPRWQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAW5</accession>
    <name>Q1DAW5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552063.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1973"/>
    <dbReference type="EnsemblBacteria" id="ABF90013">
        <property type="protein sequence ID" value="ABF90013"/>
        <property type="gene ID" value="MXAN_1973"/>
    </dbReference>
    <dbReference type="GeneID" id="41359384"/>
    <dbReference type="KEGG" id="mxa:MXAN_1973"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789227_0_0_7"/>
    <dbReference type="OMA" id="IHCCGNT"/>
    <dbReference type="OrthoDB" id="605503at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="38822" checksum="6B03B8840794A730" modified="2006-07-11" version="1">MSAPNIRRAVQLLPACATTGIGSLPHTQVELGLQAALALDIPFLPQLPVGKPSELMIPAALEGLPGLAFDEEGLCTVDLAAWQAGRAAFEARLEAAFQSGQFEAFEPSPEACRAWRPFLWEVEARKLAFAKAQLAGPFTVRSVARTTDGQPALEVPGLDEAMYRLSLARSLAMVKALRRAGTTPLFYLDEPGLYALQRTNPRHLIAMQELKLLVVALQREGALVGLHCCGNTDWAALLDVQPDLLSLDVRLSLDAMVEAGAALERFLAAGATLSLGIIPTDLASTYEVGELVDSVEATLKAALPAGFTFAQVVSTVVLTPACGLAMRSVIDAERILEELKVAQRRLRSALSAERPSVDTVNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY8</accession>
    <name>Q1DAY8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552040.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1947"/>
    <dbReference type="EnsemblBacteria" id="ABF89417">
        <property type="protein sequence ID" value="ABF89417"/>
        <property type="gene ID" value="MXAN_1947"/>
    </dbReference>
    <dbReference type="GeneID" id="41359360"/>
    <dbReference type="KEGG" id="mxa:MXAN_1947"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_1_7"/>
    <dbReference type="OMA" id="GCDGWLE"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="34736" checksum="7996B8CF32C4C114" modified="2006-07-11" version="1">MKPAVVVTGISGNLGRTLAKLLHKHERIIGIDRRPFAGRPKDVEMYELDLRKKKAEDVFRKNEIRAVIHMGIMHDPRMSEEEHHSFNVVGTTRLLEYCAKYGVKKVVVLSSANVYGPSPDNSNFLTEDAPLMAASRFSGVRDLIEVDMLAHSFFWKHPHIETVILRPVHIVGPTIKNAPSNYLRMRRPWMMAGFDPMVQLIHVEDVARAMVEALRPEPKGVYNVVGPGEVPLSAVMRELGNTPIPVPHPVARPLLGMLFKYRLANFPPPELDHIQFLCAVDGSRWVKDVAWKPRHSMRDTIRSVQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB45</accession>
    <name>Q1DB45_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative helicase, ATP-dependent, intein-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1882"/>
    <dbReference type="EnsemblBacteria" id="ABF91531">
        <property type="protein sequence ID" value="ABF91531"/>
        <property type="gene ID" value="MXAN_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1882"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312560_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="5">
        <location>
            <begin position="312"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="4">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="589"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="794"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="938" mass="102835" checksum="46640AC0A3325BC8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB56</accession>
    <name>Q1DB56_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative terminase, atpase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1871"/>
    <dbReference type="EnsemblBacteria" id="ABF89460">
        <property type="protein sequence ID" value="ABF89460"/>
        <property type="gene ID" value="MXAN_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1871"/>
    <dbReference type="eggNOG" id="COG4373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756093_0_0_7"/>
    <dbReference type="OMA" id="GIFWEID"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="42202" checksum="C1091536BEA00BA1" modified="2006-07-11" version="1">MTLGIVKRTEDDLTQWLATESGFISGLCQYDNEPVVLEPYQQSFLGNRSRFRWVAKSRQVGFSFLFALEALARCHLRDGHTAVFVSYNLSDAVEKVLIARQVYEELPLAYQKKLVTDAKTELAFESNSRGRRLSRIISVPAKPPRGKRGDVYLDELAHLVNDREVYTGSTALILRSHGQLTGGSTPLGRRGIFWEIDTQELRKYPHHTRQLVPWWLCRFFSLNVRRAAVEAPLMSTEERVARFGRPVLTEQFDSLPLEDFQQEFECLLRRRVLQLPPLRAHPPVHHGRAVLGPGCVRRARAPGPPGGGLRRGPHARPLRAGRLRRGGGPLHVPPAEELRGRALRGAGGSPAPHPLRPSRGAPQRGQERHRHESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ1</accession>
    <name>Q1DBJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551841.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92312">
        <property type="protein sequence ID" value="ABF92312"/>
        <property type="gene ID" value="MXAN_1732"/>
    </dbReference>
    <dbReference type="GeneID" id="41359166"/>
    <dbReference type="KEGG" id="mxa:MXAN_1732"/>
    <dbReference type="HOGENOM" id="CLU_357082_0_0_7"/>
    <dbReference type="OMA" id="QDEGARM"/>
    <dbReference type="OrthoDB" id="127771at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188361" evidence="2">
        <location>
            <begin position="24"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="781" mass="85984" checksum="C398E5349F2BC14D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL2</accession>
    <name>Q1DBL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine kinase PKN8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pkn8</name>
        <name evidence="4" type="ORF">MXAN_1710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551820.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1710"/>
    <dbReference type="EnsemblBacteria" id="ABF92144">
        <property type="protein sequence ID" value="ABF92144"/>
        <property type="gene ID" value="MXAN_1710"/>
    </dbReference>
    <dbReference type="GeneID" id="41359148"/>
    <dbReference type="KEGG" id="mxa:MXAN_1710"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009368_0_0_7"/>
    <dbReference type="OMA" id="FGARPFQ"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="87"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1049" mass="114313" checksum="7752862DAA25338C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR7</accession>
    <name>Q1DBR7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551765.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1654"/>
    <dbReference type="EnsemblBacteria" id="ABF88737">
        <property type="protein sequence ID" value="ABF88737"/>
        <property type="gene ID" value="MXAN_1654"/>
    </dbReference>
    <dbReference type="GeneID" id="41359096"/>
    <dbReference type="KEGG" id="mxa:MXAN_1654"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_0_7"/>
    <dbReference type="OMA" id="HEFAVQF"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="26717" checksum="B70187D6350A2140" modified="2006-07-11" version="1">MATRNKAGATGGPKRGRPRGRTEQGHETRQRLYATALGFISARGYEATHLRDIAKEAGVSVGLLYRYFPSKRAIVLALYDELSSAYAARAEALPAGSWRERFLFALRASLGVLGPHHEVLKALIPVLVGGEEDGLFAPQTAFSRQRVQAVFEDAVAGATDVPSNATVAHALGRLLYVAHLAVVLWWLLDKSPRQRATEGLVSMLAGLLPPASLLLRLPGAGSMVLGADALCRQALFGEPARAQAEEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB8</accession>
    <name>Q1DCB8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter, MotA/TolQ/ExbB proton channel family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551564.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1448"/>
    <dbReference type="EnsemblBacteria" id="ABF92363">
        <property type="protein sequence ID" value="ABF92363"/>
        <property type="gene ID" value="MXAN_1448"/>
    </dbReference>
    <dbReference type="GeneID" id="41358894"/>
    <dbReference type="KEGG" id="mxa:MXAN_1448"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_2_2_7"/>
    <dbReference type="OMA" id="NAFQLMA"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="80"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="23843" checksum="D7B7C6BDAC512721" modified="2006-07-11" version="1">MQFTLAEIWDHTGLFARMIIFTLGIMSIASLVVLAERMIVFRKTRSDSRNFAAKMGAILAKGDLNTAANTNLGKDVGHLGRVINSGLTAYRISPNNKDVAVESVARALERQAQREVQSMKRGLGLLATVGSTAPFVGLLGTTMGIVNAFQLMAQAGSGGLGTISAGIAEALITTAFGLLVAIPAVMAYNFLQGWVDARSVDISESSNEFLDVVARHLGGGAQSSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ5</accession>
    <name>Q1DCJ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1371"/>
    <dbReference type="EnsemblBacteria" id="ABF87330">
        <property type="protein sequence ID" value="ABF87330"/>
        <property type="gene ID" value="MXAN_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1371"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_5_0_7"/>
    <dbReference type="OMA" id="IKVEFYR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="14229" checksum="6A15475A85AB0787" modified="2006-07-11" version="1">MKTAMSISPTRRQAALDALKLDDESLLKACEVDYFIASGPGGQHRNTTASGVRLTHAPTELSVSATERRSQVQNKGVALERLREGLKVLTFVPKVRRATKPTAGSKRRRLEGKKRTSEKKALRNSKSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK3</accession>
    <name>Q1DCK3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">acnA</name>
        <name evidence="13" type="ORF">MXAN_1363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551480.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1363"/>
    <dbReference type="EnsemblBacteria" id="ABF90110">
        <property type="protein sequence ID" value="ABF90110"/>
        <property type="gene ID" value="MXAN_1363"/>
    </dbReference>
    <dbReference type="GeneID" id="41358809"/>
    <dbReference type="KEGG" id="mxa:MXAN_1363"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_7"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="67"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="12">
        <location>
            <begin position="707"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="909" mass="98215" checksum="EB6AE2DB68177C17" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCQ7</accession>
    <name>Q1DCQ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551426.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88251">
        <property type="protein sequence ID" value="ABF88251"/>
        <property type="gene ID" value="MXAN_1309"/>
    </dbReference>
    <dbReference type="GeneID" id="41358756"/>
    <dbReference type="KEGG" id="mxa:MXAN_1309"/>
    <dbReference type="HOGENOM" id="CLU_1068867_0_0_7"/>
    <dbReference type="OrthoDB" id="1052451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="29124" checksum="06EDC77C7247F693" modified="2006-07-11" version="1">MAKLAALREDSGRAILQLMRQVDPTASRDVLVRTVDELCVHFHVVAVATLLVDGNPQGFFLNLCRAAENWRRLLTHCRLKQWALPASRHMDPLLGAVAAGHWNLARQVAELSETRWLPDEEYRSEHARAQLFLALVSPGTRDVVIPRVEALEGLGLETETDRVACARALLDGDADTFSEAFKHAVLVHGEDIEKRAKLFTTPVTRFAPKRAIWLEGLAWLRLSERADIASFDEHFQYCPPLARTPMTSQYAGDWVVSLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS5</accession>
    <name>Q1DCS5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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                <person name="Hinkle G."/>
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        <property type="entry name" value="AMP-bd_C"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="600"/>
        </location>
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        <location>
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            <end position="1659"/>
        </location>
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        <location>
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            <end position="835"/>
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        <location>
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        <location>
            <position position="560"/>
        </location>
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        <location>
            <position position="1620"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2108" mass="231573" checksum="7A2DF61040C24925" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCZ0</accession>
    <name>Q1DCZ0_MYXXD</name>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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            <end position="237"/>
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            <end position="549"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="648"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="EMBL" id="ABF90405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="792" mass="82170" checksum="972757E7CDFD5C53" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD04</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="353" mass="39142" checksum="6234BDF57B7A696E" modified="2006-07-11" version="1">MMTGVDALSCLRKSHASTRDMPTRLRRCLSSVREPLTKSTRIYAGNDCVPMERRRAAQPRERRGAVAETVCESSVVGMRHASVGAMSHAAICRRGSAKKHVSHSEYGLRAARQSELVSRILAARASGNAVLERRLSAELLDSVRPLIRCIVGALLPIAGSLSPDDLAQVAAMAMLRAVSKYDATRGRQSFGQVAYFRARAACEQYARLHGTDVHLSDGEHKRRTVRSIRSNERNVVRVHRMDIPSHFSDGASADDSWVDELESALREMSCLDADEETPEAKLLAAERRALVFDAVRRLAPEQRELVSRVFGINRPAQSVRSVAEAWKAPKSRIDRMLARALAELREALVRQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDD1</accession>
    <name>Q1DDD1_MYXXD</name>
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        <submittedName>
            <fullName evidence="9">NADH dehydrogenase I, L subunit</fullName>
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        <name evidence="9" type="ORF">MXAN_1082</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ABF93157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF93157">
        <property type="protein sequence ID" value="ABF93157"/>
        <property type="gene ID" value="MXAN_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1082"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="291"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF93157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="731" mass="79091" checksum="EC2A7CF5EDC2C4FC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-02-09" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDD3</accession>
    <name>NUON_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoN</name>
        <name type="ordered locus">MXAN_1080</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551200.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDD3"/>
    <dbReference type="SMR" id="Q1DDD3"/>
    <dbReference type="STRING" id="246197.MXAN_1080"/>
    <dbReference type="EnsemblBacteria" id="ABF87238">
        <property type="protein sequence ID" value="ABF87238"/>
        <property type="gene ID" value="MXAN_1080"/>
    </dbReference>
    <dbReference type="GeneID" id="41358531"/>
    <dbReference type="KEGG" id="mxa:MXAN_1080"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_007100_1_1_7"/>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="OrthoDB" id="1664448at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000391184" description="NADH-quinone oxidoreductase subunit N">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <sequence length="519" mass="54859" checksum="5C04A0DFD3596D57" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDF2</accession>
    <name>Q1DDF2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_1060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551181.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1060"/>
    <dbReference type="EnsemblBacteria" id="ABF87008">
        <property type="protein sequence ID" value="ABF87008"/>
        <property type="gene ID" value="MXAN_1060"/>
    </dbReference>
    <dbReference type="GeneID" id="41358513"/>
    <dbReference type="KEGG" id="mxa:MXAN_1060"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="26965" checksum="4572FA22089F01E6" modified="2006-07-11" version="1">MSARLIAEGLEKSFRGRKKVVAGVSFSVAAGEVVGLLGPNGAGKTTSFNMVVGLVSPDAGRVRIGDEDLTHLPMHRRARRGVGYLPQEASVFRKLTVRDNFLAVLELQKDLDAKAREQRADTLLDEFGLTHVGESLGGDLSGGERRRAEIARSLIPQPRFILFDEPFAGVDPINVGDLQRQIFLLRERGLGVLITDHNVQDTLGICDRAYIIAQGRILEEGTPAEIAASPKARAVYLGERFRLQQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDI2</accession>
    <name>Q1DDI2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551151.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1030"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86519">
        <property type="protein sequence ID" value="ABF86519"/>
        <property type="gene ID" value="MXAN_1030"/>
    </dbReference>
    <dbReference type="GeneID" id="41358484"/>
    <dbReference type="KEGG" id="mxa:MXAN_1030"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_4_7"/>
    <dbReference type="OMA" id="AVGWKEQ"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="201"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="383" mass="42245" checksum="86810F0FA38C6C1D" modified="2006-07-11" version="1">MKQSRRLITLSHSYVVGLNRRLANEMMRVGAGAWDVTTVAPRFFHGDLSPLALQLEADEPARTEGVRAFFSRSLHTFLYGPEVHAHLARGADLVHVWEEPYVLAGLELALLTPRHVPLVFSTAQNLSKRYPPPFAQAERFVVQRASGWVAWGETVRDNLLTRPGYAERPARAIPMGVDADLFQPDRAAGESLRRELGWETSGPPVVGFLGRFVPEKGVPLLMDALDALDTPWRALFVGGGPMEGALRDWAARHTHSVRVLTGVPHAGVPRALNAMDMLCAPSQTTRQWREQFGRMLAEGFACGVPVLGSDSGEVPRTMGDAGIVLPEASVSAWTQAIANLLESPQRREELATRGRERAVTRFSWPVVAKAHLDFFTEVLEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDN3</accession>
    <name>Q1DDN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0979</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551100.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0979"/>
    <dbReference type="EnsemblBacteria" id="ABF92722">
        <property type="protein sequence ID" value="ABF92722"/>
        <property type="gene ID" value="MXAN_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="41358435"/>
    <dbReference type="KEGG" id="mxa:MXAN_0979"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_3_7"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="YHS" evidence="8">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="9">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="9">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="863" mass="90223" checksum="900EA2201D1CB82B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS9</accession>
    <name>Q1DDS9_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Serine/threonine kinase family protein</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0933</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551054.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0933"/>
    <dbReference type="EnsemblBacteria" id="ABF86395">
        <property type="protein sequence ID" value="ABF86395"/>
        <property type="gene ID" value="MXAN_0933"/>
    </dbReference>
    <dbReference type="GeneID" id="41358392"/>
    <dbReference type="KEGG" id="mxa:MXAN_0933"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006681_0_0_7"/>
    <dbReference type="OMA" id="VGWEYFA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1337" mass="144739" checksum="60B6E8CA4C92499D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDZ6</accession>
    <name>Q1DDZ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dps family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550987.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0866"/>
    <dbReference type="EnsemblBacteria" id="ABF87059">
        <property type="protein sequence ID" value="ABF87059"/>
        <property type="gene ID" value="MXAN_0866"/>
    </dbReference>
    <dbReference type="GeneID" id="41358325"/>
    <dbReference type="KEGG" id="mxa:MXAN_0866"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_1_2_7"/>
    <dbReference type="OMA" id="DDYSIGR"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="20589" checksum="ECC5FAA72F1FA405" modified="2006-07-11" version="1">MNFPSHVNLPTDAREELIDSLNTLLADAIDLHWQIKQAHWNIRGRHFYSRHELFDDLAKHVRKQADEFAERAGTLGGYAEGTIRLAAKNSELPEYDLKAVDGDDHLKALVDRFARYGASIRNGIHRSDELNDPVTSDLLTQTLGEVELDLWFLESHLHGEPRAGARRGGDVRPQDTTTSPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DED9</accession>
    <name>Q1DED9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550844.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0716"/>
    <dbReference type="EnsemblBacteria" id="ABF90711">
        <property type="protein sequence ID" value="ABF90711"/>
        <property type="gene ID" value="MXAN_0716"/>
    </dbReference>
    <dbReference type="GeneID" id="41358189"/>
    <dbReference type="KEGG" id="mxa:MXAN_0716"/>
    <dbReference type="eggNOG" id="ENOG5033MNX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156541_0_0_7"/>
    <dbReference type="OMA" id="ADREWTA"/>
    <dbReference type="OrthoDB" id="1806421at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14738" checksum="453E3718DCA25D1A" modified="2006-07-11" version="1">MSDAGIPQRVQRFISTHIDSLEKLEVLLLLRARADREWTASAVSLELRITDASAASRLEDLTNRRMLVSDGASPPSYRYGPESSEDVQAVTELAAVYSAKRVSVISFIFSRPLDKVRGFAEAFILKKDKDGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF51</accession>
    <name>Q1DF51_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550585.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0452"/>
    <dbReference type="EnsemblBacteria" id="ABF91224">
        <property type="protein sequence ID" value="ABF91224"/>
        <property type="gene ID" value="MXAN_0452"/>
    </dbReference>
    <dbReference type="GeneID" id="41357945"/>
    <dbReference type="KEGG" id="mxa:MXAN_0452"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_0_0_7"/>
    <dbReference type="OMA" id="EHDLFIQ"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="3">
        <location>
            <begin position="248"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="49218" checksum="CA56EF1DF9603CA1" modified="2006-07-11" version="1">MENKRSVAKPDGKLAVLIPGLGAVSTTLMAGVELARKGKGHPIGSLTQMGTARLGKRTDGRTVKLNELVPLAELKDVAFGAWDIIREDAYEVAVRSGVLSDKHLEEVKPFLQSIKPKQGVHDPEFVRRIEANHIKATKTHRESIEALRQDIRDFKKELNATRAVMVVCSSVETFRPLPESFKTLAAFEKALDENSPDINPTALYTYAAIKEGVPFANATPNASVDTPALQEMAKQESVAVAGRDLKSGQTMMKTVIAPALKARMLGLDGWFSTNILGNRDGEVLDDPAAFKAKEVTKSSVLDTILQPDLYPELYKKYAHKVAIHYYPPRGDAKEGWDNIDITGWLGYPMQIKVNFLCRDSILAAPLVLDIALFLDLAKRLEWRGIQEWMSFYFKTPMAQPGLPVEHDLFIQLTKLKNTLRVVAGEDPITHLGLDYYGDDLPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFA8</accession>
    <name>Q1DFA8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0394"/>
    <dbReference type="EnsemblBacteria" id="ABF91253">
        <property type="protein sequence ID" value="ABF91253"/>
        <property type="gene ID" value="MXAN_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0394"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709457_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="39747" checksum="A0BA9C31E667716D" modified="2006-07-11" version="1">MPASPPYSQALRARVRGWARALLPLLVCGVPPAMAAKPPLQRLPRLTCRAGYLDFEQLHGLPTVRAAIQQALAQNDPAALTFLTERIPEVLGEDALAALQVLDWADTAPGPEASVLLAGLREASAVRDARVAERLLTMAEQHASIDHRAQALQALETQARFGAPAQDRLMALARRSTAPQGVSLLAVRTLGRVMKNDFQAGGSEEPYLTRLLTLARESEDRHIRALAVELAASLSVRLDARAVEQLAWVLENDADANVRELAALALSDGRDTRAVLNHFSAAFPGEQRLCVRWALLRYTLRAGGAEALPQVRDYSKQDRRFARDVADFQALYDAGHVDFDRLWLNKRVYHRCPEDVEARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC6</accession>
    <name>Q1DFC6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89168">
        <property type="protein sequence ID" value="ABF89168"/>
        <property type="gene ID" value="MXAN_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0373"/>
    <dbReference type="HOGENOM" id="CLU_3404480_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="30" mass="3271" checksum="ED33294DFCCAFBB4" modified="2006-07-11" version="1">MAKMQPIFKPGEDGMLPSSLIERGLCRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFE7</accession>
    <name>Q1DFE7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S6 modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rimK</name>
        <name evidence="11" type="ORF">MXAN_0352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550490.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0352"/>
    <dbReference type="EnsemblBacteria" id="ABF90218">
        <property type="protein sequence ID" value="ABF90218"/>
        <property type="gene ID" value="MXAN_0352"/>
    </dbReference>
    <dbReference type="GeneID" id="41357850"/>
    <dbReference type="KEGG" id="mxa:MXAN_0352"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_0_1_7"/>
    <dbReference type="OMA" id="CYMNIAS"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041107">
        <property type="entry name" value="Rimk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18030">
        <property type="entry name" value="Rimk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="137"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="35877" checksum="B612CE40209F373C" modified="2006-07-11" version="1">MSPRKVKPKKVPVLPGSQAPDRPERAPRRGHAKKTVVILSRKRALYSTRRLVAAIRARGHRPLVLDTLRCCLLLAQDAPRMTYRGVEVRGVDVVVPRIGASITAYGLAVVNHFEMMGVPVLNPPTSIARSRDKLRALQYLSRSGLDIPRTVMAHDRSNVRRLVEEVNGLPVIIKLIKGTQGVGVMIAHTLPEVQTILDTFWDLGQEIVLQEFVAESEGRDVRALVVGDRVVGAMRRKAKSGEFRSNIHRGGEGQAIELTAPYTEAAVRAARVVGLEVAGVDMLEGHAGPRLMEINSSPGFEGLERATGMDIAGAIIDHALKYAEAKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ2</accession>
    <name>Q1DFJ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative asparagine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550445.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0301"/>
    <dbReference type="EnsemblBacteria" id="ABF92050">
        <property type="protein sequence ID" value="ABF92050"/>
        <property type="gene ID" value="MXAN_0301"/>
    </dbReference>
    <dbReference type="GeneID" id="41357800"/>
    <dbReference type="KEGG" id="mxa:MXAN_0301"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625327_0_0_7"/>
    <dbReference type="OMA" id="WLFRHAV"/>
    <dbReference type="OrthoDB" id="671970at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="46719" checksum="F4409D31BE942A60" modified="2006-07-11" version="1">MSHASGGMLATLPHYQSLARLAPSVWRLNPPGLAPEAVAAFLRHALPPDESVFQGVRRVPGALPRVRRSEGTPETREDEDRLAERLVAALADSVGKHLAAGAVDVSLSGGVDSAALCALAARQAPGRVRAWTMDVHFADATERRNARTVANTAGVELVDVSVPDAVLPELFEPAVLSQETAILNARAVASHAFYAEARRQGASTLLSGAGADEVLMGNPAAFAGAAARVTEDRRLVHKVLHPGPVDNLGVDLRVLRLPWDAELASGDEDHPEEVRYAAWVLWELVLPPELRGASAHGVNVCTPYLDADFADVALGLPLGVLARHGAGKWLFRHAVRTLVPDEVRLARKTPRYAHTALSSPVRARWLELYREWLTPARLAPLECIDAGATRALLERYARLAADAPEASAMDRLLMRLCSLAMLHAHASARPPCPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK2</accession>
    <name>Q1DFK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0291"/>
    <dbReference type="EnsemblBacteria" id="ABF87461">
        <property type="protein sequence ID" value="ABF87461"/>
        <property type="gene ID" value="MXAN_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0291"/>
    <dbReference type="HOGENOM" id="CLU_2012807_0_0_7"/>
    <dbReference type="OMA" id="ERMDTTR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="123" mass="13507" checksum="6D817B107C10C012" modified="2006-07-11" version="1">MWIPEGPRPCWGGGLLLGRQATAPWQVPCPVRGRFGPFPLKGEMTMADNKGSPVRGDERMDTTRPEELEREARHQKGPVRGDVTDEDVGEDRILQKGIGGYGAQKGTEPAREAPPLSDDHGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN6</accession>
    <name>Q1DFN6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550401.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0256"/>
    <dbReference type="EnsemblBacteria" id="ABF85889">
        <property type="protein sequence ID" value="ABF85889"/>
        <property type="gene ID" value="MXAN_0256"/>
    </dbReference>
    <dbReference type="GeneID" id="41357756"/>
    <dbReference type="KEGG" id="mxa:MXAN_0256"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_7"/>
    <dbReference type="OMA" id="IRINHMG"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="34"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="386" mass="40453" checksum="762C716FCC571982" modified="2006-07-11" version="1">MRDLLMIPGPVEFEPEVLQALGAPTLGHTDPAFIAVFGRALKRLREVCLAPSAQPFVVSGSGTLAMELAVANLVEPGDAALVVNTGYFSDRMAKILERHGARVTHVRAPPGDVPSLDEVETHLSKGGFKVLSVTHVDTSTGVLAPAEALVRAARKHGVLSVVDGVCATAAETFRQDAWEADVYLTASQKAVGVPPGLALLTVGPRAMEAWRKRKTPVASVYADFAEWLPIMEAYEAGKPAYFATPPVNLVAALDVSLGQILAEGMDARFARHQRMARAFRAAWKAMGLRLLPTSDAVAANALSAVYYPDGVDAALVGGVKGQGVVVAGGLHPDLKTRYFRVGHMNRVGPADVLATVGALERALIAAGHRSEPGAAVAAAQASLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFP8</accession>
    <name>Q1DFP8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550389.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0244"/>
    <dbReference type="EnsemblBacteria" id="ABF87754">
        <property type="protein sequence ID" value="ABF87754"/>
        <property type="gene ID" value="MXAN_0244"/>
    </dbReference>
    <dbReference type="GeneID" id="41357744"/>
    <dbReference type="KEGG" id="mxa:MXAN_0244"/>
    <dbReference type="eggNOG" id="COG4335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064289_0_0_7"/>
    <dbReference type="OMA" id="NDIAKDH"/>
    <dbReference type="OrthoDB" id="1273957at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="41266" checksum="FCC4C08E642D7CF3" modified="2006-07-11" version="1">MADHLKTFFDARLVERLGASLHAAAPTFPRAAFIREAEKGLDGHELMDRARHIAGALHRALPQDYPEAVEVLLRSLGPRTEATEGGAMASFFYLPHTIFVAEHGLEHFEPSMRAQHVLTQRFTAEFSIRPYLERHTAKTLARLREWTEDPSEHVRRLVSEGTRTRLPWASRLREFQKDPTPVLALLERLKDDPALYVRRSVANNLNDIGKDHPALLVQVATAWMKNATPEREWLVRHALRSSIKRGEPAALAVVGARPPSGIEARVTQLPRRAALGSTVEVHFEVTNRSKQQQTLVVDLAVHFQKANGEARPKVFKVRELLLGPGQAETVSKRVSFAQLSTRKHYAGPHRFEALVNGQGLPLGVVEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS4</accession>
    <name>Q1DFS4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550363.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0217"/>
    <dbReference type="EnsemblBacteria" id="ABF87788">
        <property type="protein sequence ID" value="ABF87788"/>
        <property type="gene ID" value="MXAN_0217"/>
    </dbReference>
    <dbReference type="GeneID" id="41357719"/>
    <dbReference type="KEGG" id="mxa:MXAN_0217"/>
    <dbReference type="HOGENOM" id="CLU_1359710_0_0_7"/>
    <dbReference type="OMA" id="ASSQCYQ"/>
    <dbReference type="OrthoDB" id="1388448at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="229" mass="23775" checksum="9E2A06B5A86B3EEA" modified="2006-07-11" version="1">MARCLSTVASARRCPPDEEEQPMKKKLLLSAVMTSALSLVGCGESDPVDNTPNLSTPQGILAFVEGKTLTMTGANIPSHPNGFSEDINFGASSQCYQSVTMTVQGGNFRVDSIPGTIEGAPNAGMSGTCNPELPQNALSFTSTVVSIENVQGDGECFDVAFTYPGFRQVGRGAFSADRRTLDLELFFEGGATGANCAAGGVGSATVNQVIGGESRPFDGKAVQRYTIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFU8</accession>
    <name>Q1DFU8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550339.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0193"/>
    <dbReference type="EnsemblBacteria" id="ABF89338">
        <property type="protein sequence ID" value="ABF89338"/>
        <property type="gene ID" value="MXAN_0193"/>
    </dbReference>
    <dbReference type="GeneID" id="41357696"/>
    <dbReference type="KEGG" id="mxa:MXAN_0193"/>
    <dbReference type="HOGENOM" id="CLU_668739_0_0_7"/>
    <dbReference type="OMA" id="YFHREEF"/>
    <dbReference type="OrthoDB" id="1332450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="367" mass="38603" checksum="B04350199F075143" modified="2006-07-11" version="1">MALSVQYFHREEFETRTLRALGGAACMGLVAGAVPDLHLTPEYLAIVAAAQACVKPTGVHPLALRLALTVLPALPYFFRAPEPLPVSLAGALAAAMVAWLGHGREQPGQPAAVATSAAAAGLLVPLGLYVQQVLEARFLGSDGLLSALVGFLVVGLFWSIGTLPANLRVELDAVEARGRQLQDALKGDSHTLATRALALYRQCKDVVTKMPPSTGRTELLGVLEKMTGDSFSLAEVHFGLEAQLGSVVANDVDAQVRELRERAAATQDAVARRQLELAASSLGEELNHLDVLARRKERLLAQLHAQVALLERARVSFIGVQGNELGAKGAQAADLARKLKQLGEPSSSGGPDDVASVAAPNPTRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFZ2</accession>
    <name>Q1DFZ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA_27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550295.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0148"/>
    <dbReference type="EnsemblBacteria" id="ABF87684">
        <property type="protein sequence ID" value="ABF87684"/>
        <property type="gene ID" value="MXAN_0148"/>
    </dbReference>
    <dbReference type="GeneID" id="41357651"/>
    <dbReference type="KEGG" id="mxa:MXAN_0148"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006135_0_1_7"/>
    <dbReference type="OMA" id="YLTHHRH"/>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_27" evidence="4">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="747"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="842"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118270" checksum="1D3CAAB45B6171A3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVG8</accession>
    <name>Q1CVG8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557404.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7502"/>
    <dbReference type="EnsemblBacteria" id="ABF87007">
        <property type="protein sequence ID" value="ABF87007"/>
        <property type="gene ID" value="MXAN_7502"/>
    </dbReference>
    <dbReference type="GeneID" id="41364636"/>
    <dbReference type="KEGG" id="mxa:MXAN_7502"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_9_1_7"/>
    <dbReference type="OMA" id="NYLSFSW"/>
    <dbReference type="OrthoDB" id="1498264at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="146" mass="16695" checksum="5D1E24073956DE61" modified="2006-07-11" version="1">MTTKTIRRELKFTQSPAVVWRALATSEALADWMYPNDFEPRVGHRFTFRVPPDPRAQFDGLVVHCEVLRCAPPSELEFTWVVGEGWLDTRVRYRLEADGDGTRVLFEHSGFKEDQAFHGAEYGWKMMHGKLAKALEKASDNPALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW5</accession>
    <name>Q1CVW5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557263.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7350"/>
    <dbReference type="EnsemblBacteria" id="ABF86580">
        <property type="protein sequence ID" value="ABF86580"/>
        <property type="gene ID" value="MXAN_7350"/>
    </dbReference>
    <dbReference type="GeneID" id="41364511"/>
    <dbReference type="KEGG" id="mxa:MXAN_7350"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568278_0_0_7"/>
    <dbReference type="OMA" id="FCLASER"/>
    <dbReference type="OrthoDB" id="523624at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="57059" checksum="35AF7B76F7DBBE3A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVX7</accession>
    <name>Q1CVX7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7333"/>
    <dbReference type="EnsemblBacteria" id="ABF85959">
        <property type="protein sequence ID" value="ABF85959"/>
        <property type="gene ID" value="MXAN_7333"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7333"/>
    <dbReference type="eggNOG" id="ENOG5031VVE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959432_0_0_7"/>
    <dbReference type="OMA" id="LYEHCES"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187828" evidence="1">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="30650" checksum="0938724397F95939" modified="2006-07-11" version="1">MGGRSCAMKKWMLGLSCLGLMACSDGAGTVTFTTYGEDYIEKEIPAAVGGEDGIVDGWTVRFSKFLVVLGEVKVGNHDETAIEMMQARVFDVHKPGPVVVETFRDVPAQEWDHVSFAIAPNTNAVAGNADAADVTRMKDGGYSVYMEGRATKGEQTKRFAWGFTTNTVYEHCESPGLGAGVTVPKDGEETVQLTIHGDHLFFDDLQSPDAQMRFDALAAADSMGIAGPDGEVTLEELAAVDLTELPAGQYGTGGVGNVQTLRDFVTALTRNLGHYRGEGECEPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW64</accession>
    <name>Q1CW64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557165.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7246"/>
    <dbReference type="EnsemblBacteria" id="ABF90510">
        <property type="protein sequence ID" value="ABF90510"/>
        <property type="gene ID" value="MXAN_7246"/>
    </dbReference>
    <dbReference type="GeneID" id="41364412"/>
    <dbReference type="KEGG" id="mxa:MXAN_7246"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137090_0_0_7"/>
    <dbReference type="OMA" id="IFILEAH"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="244" mass="26675" checksum="E79C319687DC32DE" modified="2006-07-11" version="1">MSASGDGSEKSLADLMAGVAVVFLLLAVIFILEAHEQREAAIRDKEAAIEKVDSQKEGVQESLIALREDLISLDAMLDGGFIALSGLDGGVNALEIEFKNMQFGLGQCRTPLAYVEQFERGAVPLIHRVCQAVEAMRDAGAEPSIILEGHTDDRPFLGTSWECGVREGVARYSFENNVRASAARAQEVFFTVRNQLRDAGYERDCFDSNFVVSGRGQTAPRPGTDGSEPENRRLVIRVRGDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW80</accession>
    <name>Q1CW80_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7230"/>
    <dbReference type="EnsemblBacteria" id="ABF90215">
        <property type="protein sequence ID" value="ABF90215"/>
        <property type="gene ID" value="MXAN_7230"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7230"/>
    <dbReference type="HOGENOM" id="CLU_2524080_0_0_7"/>
    <dbReference type="OMA" id="VRPLFGM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="84" mass="8727" checksum="1BEDF868EFC25A33" modified="2006-07-11" version="1">MRLRSNGTRGVASRTTGVRVSMHSQGSKVLRTVTVVLAVLLLVFVVLTAAGTFFGGTKIRPLFGMPEGGLHAHDDGDAAPPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD5</accession>
    <name>Q1CWD5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557094.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7175"/>
    <dbReference type="EnsemblBacteria" id="ABF92141">
        <property type="protein sequence ID" value="ABF92141"/>
        <property type="gene ID" value="MXAN_7175"/>
    </dbReference>
    <dbReference type="GeneID" id="41364348"/>
    <dbReference type="KEGG" id="mxa:MXAN_7175"/>
    <dbReference type="HOGENOM" id="CLU_2330804_0_0_7"/>
    <dbReference type="OMA" id="DCAKNDP"/>
    <dbReference type="OrthoDB" id="2151704at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187991" evidence="2">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="98" mass="10055" checksum="DE176E9D93A04C52" modified="2006-07-11" version="1">MNTLTKFLAGTAFLFSLTFAPGAQAQECYEACGCNVPCNRVCTDNGQPSRCGLAGAPCLGDCAKNDPQASASDKKASDKAAPACGQQQTDKASEEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWM0</accession>
    <name>Q1CWM0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557009.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7090"/>
    <dbReference type="EnsemblBacteria" id="ABF87738">
        <property type="protein sequence ID" value="ABF87738"/>
        <property type="gene ID" value="MXAN_7090"/>
    </dbReference>
    <dbReference type="GeneID" id="41364265"/>
    <dbReference type="KEGG" id="mxa:MXAN_7090"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_1_2_7"/>
    <dbReference type="OMA" id="LAPFKGQ"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19859" checksum="F99189F716F2FD54" modified="2006-07-11" version="1">MSQNLYDIPLKSIDGAPQSLGQFKGKVLLVVNVASKCGLTPQYEGLEKLYERKRAEGFEVLGFPANNFLGQEPGSESEIKAFCTLTYDVKFPLFSKISVVGADKHPLYHALTGAIPDAVGEGPMRSRLQGYGITANPVPEVQWNFEKFLVGRDGRVAARFAPDVAADDARLLSAIDAELAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX50</accession>
    <name>Q1CX50_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 3-oxoacyl-(Acyl-carrier-protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6909"/>
    <dbReference type="EnsemblBacteria" id="ABF89312">
        <property type="protein sequence ID" value="ABF89312"/>
        <property type="gene ID" value="MXAN_6909"/>
    </dbReference>
    <dbReference type="GeneID" id="41364091"/>
    <dbReference type="KEGG" id="mxa:MXAN_6909"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_7"/>
    <dbReference type="OMA" id="IRCNSVM"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="26723" checksum="B765D9656F6AAA4A" modified="2006-07-11" version="1">MDLELRGKTALITGSSRGIGRAIASVLAREGVRVCLSARGAEALEATAAQLRAGGADVATVVTDVATQAGAVEAVEAAVRAFGRLDILVNNVGGSGGAGAFHSATAEQWTSVLDRNLLSAVWCSQRAVEAMRQQGGGCIVHINSIFGREYATSAPYTTAKAGITALTKEMAVDLAQYRIRVNGVAPGSILFPGGSWDKRQKADPEKVARLVRDELPWGRFGAPEEVADVVAFLCSERARWVTGATLPVDGGQGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX79</accession>
    <name>Q1CX79_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6879"/>
    <dbReference type="EnsemblBacteria" id="ABF91788">
        <property type="protein sequence ID" value="ABF91788"/>
        <property type="gene ID" value="MXAN_6879"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6879"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="GPARWIN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="244" mass="26294" checksum="019104A8150CEFA8" modified="2006-07-11" version="1">MRRMATAFITGAGIRIGSAVARALGRSGYDLALHANRSLEPLEALADELRGLGRRVTLHAADLSRPEAVDSLAAQVREAWPALDVVVHNAGLFERTDFAAISRDQYRTMMAVNLDAPFFLTQALLPALRAGKDPLVVHLTDVGGERPVSHYAHYSVSKAGLIMLTRALAVELAPHIRVNAVSPGTVAFPEDFDAEARDAVLRRIPMGREGNVEDIARTVVFLAREAPYITGQVIAVDGGRSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXR2</accession>
    <name>Q1CXR2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibril biogenesis regulator DifC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">difC</name>
        <name evidence="2" type="ORF">MXAN_6694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-2012616">
            <id>Q1CXR2</id>
        </interactant>
        <interactant intactId="EBI-2012627">
            <id>Q1CXR4</id>
            <label>difE</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556619.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CXR2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6694"/>
    <dbReference type="EnsemblBacteria" id="ABF92146">
        <property type="protein sequence ID" value="ABF92146"/>
        <property type="gene ID" value="MXAN_6694"/>
    </dbReference>
    <dbReference type="GeneID" id="41363887"/>
    <dbReference type="KEGG" id="mxa:MXAN_6694"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_7"/>
    <dbReference type="OMA" id="RHVIFRV"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="15128" checksum="39531AF62D5361F8" modified="2006-07-11" version="1">MRHVIFRVEKERYGLPLSAVREVVVPPERFTRVPRAPLAITGVMNLRGRVVTVVELRQLLSLPEGPTPPGRVVLLDRGRRDLGLLVTDVDGIEAVERVSTAPGKMTPAIRGVARLGGLGVTVLDPEGLDAAVVALFTHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX6</accession>
    <name>Q1CXX6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prenyltransferase, UbiA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556555.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6629"/>
    <dbReference type="EnsemblBacteria" id="ABF92266">
        <property type="protein sequence ID" value="ABF92266"/>
        <property type="gene ID" value="MXAN_6629"/>
    </dbReference>
    <dbReference type="GeneID" id="41363827"/>
    <dbReference type="KEGG" id="mxa:MXAN_6629"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029423_2_0_7"/>
    <dbReference type="OMA" id="HQWAKNA"/>
    <dbReference type="OrthoDB" id="1213919at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="490" mass="54007" checksum="B15990167267E46E" modified="2006-07-11" version="1">MTAPVTPLPMLPQTPLPEDPPDVPLAVDLDGTLVRTDTLHENLLVLFKRAPWLLFLAPLWVLKGKAFFKAEVARRAALDAASLPYHEEFLTYLHEEKARGRRLVLATAADRRIAEAVAAHLGLFSDVVASEATVNLSGERKLAKLKELLGTFDYAGNDAVDLPLWRECRRIVVVHAPAGVLKQAQGLGRDVHRVFERPATRLRTWVKALRVHQWAKNALVFVPLLAAHKGTEPDKLIQALLAFTAFSLCASSVYVLNDLLDLDSDRRHPTKKQRPFAACTLSVSTGVMLAPVLLLAGAAVCLLLPPAFSALLGTYYVLTLAYSLRLKQVVMLDVLVLAGLYTVRIFGGALAVDVPTSSWLMMFSMFLFLSLALVKRLSEVRRLRQSNETSAHGRGYLAQDYEQLASLGAASGQVSVLVLALYITSDEVTALYGHPERLWLICPVMLYWVGRVWLLAHRGLVNEDPLVFALRDRVSYAVGLVCALVLWAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY19</accession>
    <name>Q1CY19_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556512.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6583"/>
    <dbReference type="EnsemblBacteria" id="ABF88182">
        <property type="protein sequence ID" value="ABF88182"/>
        <property type="gene ID" value="MXAN_6583"/>
    </dbReference>
    <dbReference type="GeneID" id="41363786"/>
    <dbReference type="KEGG" id="mxa:MXAN_6583"/>
    <dbReference type="HOGENOM" id="CLU_1174417_0_0_7"/>
    <dbReference type="OMA" id="SVQWQLL"/>
    <dbReference type="OrthoDB" id="1546984at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25330" checksum="2E336DDA8E73A5E3" modified="2006-07-11" version="1">MAGRGTSFPRCRDSSVARMASGTVLLRLGVLGGLLAGSAALAADTADVPRAEAAPVGPESSSVQWQLLAGGLASLDGYASTGYQGWLLGAGWEFPRLRFRFQFLAGLPSSMVETRTEVKLEQYVFGFWLDTPMLRSGAWRWSVGAGAGFLLFGRTAFARVGGLDTAGPRFVPALLTGPDTSLRWRFSKYFAVEGSLAMDIVFGRPLIGFQSAQGFEPLHEGWAVRPRLSVAMMVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY58</accession>
    <name>Q1CY58_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6543"/>
    <dbReference type="EnsemblBacteria" id="ABF87876">
        <property type="protein sequence ID" value="ABF87876"/>
        <property type="gene ID" value="MXAN_6543"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6543"/>
    <dbReference type="eggNOG" id="COG2908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071282_0_0_7"/>
    <dbReference type="OMA" id="FTHGHHH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="102"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="37529" checksum="5999C690F7F983C3" modified="2006-07-11" version="1">MSNGHEFKSMCGSARCGPADVRCRITVHPRGDTKHTGLMDECAGRAQGGGSPGSGASDAGPRGKVHRGDTRMASGCSEIFAHRPFRRRTQSLPFRGTLGERMRIAVISDLHLGRRDAADHFGHDDSGFLRFLRFLEGNFERIVLLGDIFETLTPRTPGRKVAELLAARAAHPEIVRRFELPRYHYIHGNHDLVAGTVLGAPDQMILEADGVRMLFTHGHHHDWMIRKARLLSEAAVWAGAWLRRMRMRAMFRWFQALDLKITNALPDPARCTFQRWAMARANAHHADVVVTGHTHLGLRVEHGSKLFLNSGTCSEGQFSFLSLDTRAASYSLHTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY66</accession>
    <name>Q1CY66_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system, mannose/fructose/sorbose family, IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556465.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6535"/>
    <dbReference type="TCDB" id="4.A.6.1.12">
        <property type="family name" value="the pts mannose-fructose-sorbose (man) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89943">
        <property type="protein sequence ID" value="ABF89943"/>
        <property type="gene ID" value="MXAN_6535"/>
    </dbReference>
    <dbReference type="GeneID" id="41363742"/>
    <dbReference type="KEGG" id="mxa:MXAN_6535"/>
    <dbReference type="eggNOG" id="COG2893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123235_0_1_7"/>
    <dbReference type="OMA" id="RNITCAS"/>
    <dbReference type="OrthoDB" id="2008912at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="14758" checksum="93713F47C50EACE4" modified="2006-07-11" version="1">MVGLVVAAHGRLAEELVSTAEQIVGELPAVAACNIEPGTPVEDIRAKMKQAIARVDEGAGVIILADLFGGTPCKESLMMCQRMNVEVLAGVNLPMLLKANSLRSEQLSLPEMANQLASHGQRNITCASALLREAQQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY72</accession>
    <name>Q1CY72_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556459.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6529"/>
    <dbReference type="EnsemblBacteria" id="ABF88155">
        <property type="protein sequence ID" value="ABF88155"/>
        <property type="gene ID" value="MXAN_6529"/>
    </dbReference>
    <dbReference type="GeneID" id="41363736"/>
    <dbReference type="KEGG" id="mxa:MXAN_6529"/>
    <dbReference type="HOGENOM" id="CLU_116236_0_0_7"/>
    <dbReference type="OMA" id="FNPANIQ"/>
    <dbReference type="OrthoDB" id="2018655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="22033" checksum="21F2FC53E3F82483" modified="2006-07-11" version="1">MGLRPRGGTRPDPAPVRAGRTAVACQHGYRTRRGFRMRAVVCNLPGRAQGLAPGASMFNPANIQMGMTARDRDGEKVGTIIAADAAGFFIGRGRLFMRDCRLSFSDVADIDGEDVYLREELSHLPDLKPEALAPARRTSTTAGLPLQHDLTGGLGWADDDTDEEAQVSSPARESSGMQQWASGEGEAAPRREAPSADARRYTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF6</accession>
    <name>Q1CYF6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6443"/>
    <dbReference type="EnsemblBacteria" id="ABF89406">
        <property type="protein sequence ID" value="ABF89406"/>
        <property type="gene ID" value="MXAN_6443"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6443"/>
    <dbReference type="HOGENOM" id="CLU_1883507_0_0_7"/>
    <dbReference type="OMA" id="RPGDPLM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="14756" checksum="CC941AF5B75F47A3" modified="2006-07-11" version="1">MRVPGRDGGAMTRINSFTGPMIQPATTQAQARAASTSFGALVNPMAPANRPGDPLMVSGGAVVASALASVGSSPNNGILNSYLSAVGRGPISEDGSRGSVSQAPAGSEQAQQEQVLMELAEMSAATLSNSILHMGNKMKVDLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF7</accession>
    <name>Q1CYF7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aceA</name>
        <name evidence="9" type="ORF">MXAN_6442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556374.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6442"/>
    <dbReference type="EnsemblBacteria" id="ABF92843">
        <property type="protein sequence ID" value="ABF92843"/>
        <property type="gene ID" value="MXAN_6442"/>
    </dbReference>
    <dbReference type="GeneID" id="41363651"/>
    <dbReference type="KEGG" id="mxa:MXAN_6442"/>
    <dbReference type="eggNOG" id="COG2224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_0_7"/>
    <dbReference type="OMA" id="LEKDWAE"/>
    <dbReference type="OrthoDB" id="152545at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="428" mass="46965" checksum="61F6BB7A8D0FD2AE" modified="2006-07-11" version="1">MYDATPTTADTSPHAKLHAQRFEGIKRNYTPKDVEKLRGSITVSHTLAELGAKKLWELLHTEDYINALGSLTGNQAVQMVRAGLKAIYLSGWQVAADANSAGQMYPDQSLYPVDSVPTVVRKINNALRRADQIDHAEGRKDRYWFAPIIADAEAGFGGPLNAFELMKGMIEAGAAGVHFEDQLASEKKCGHMGGKVLVPTSHFIRTLNAARLAADVMGVPTLLVARTDADSAKLLMSDADEYDHAFIDKKSGRTPEGFYRLNGGLDCAIARGLAYAPYADLVWCETSTPDLAQAKKFAESIRAKYPNKLLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKFQFVTLAGFHALNFGMYELARKYKDRGMAAYSELQQAEFAAEKDGYTATRHQREVGTGYFDQVAEAICGGNASTLALTESTEAHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYG6</accession>
    <name>Q1CYG6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556365.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6433"/>
    <dbReference type="EnsemblBacteria" id="ABF88744">
        <property type="protein sequence ID" value="ABF88744"/>
        <property type="gene ID" value="MXAN_6433"/>
    </dbReference>
    <dbReference type="GeneID" id="41363642"/>
    <dbReference type="KEGG" id="mxa:MXAN_6433"/>
    <dbReference type="eggNOG" id="COG4922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_1_7"/>
    <dbReference type="OMA" id="VVESWDI"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="161" mass="18135" checksum="89BE4501C901956B" modified="2006-07-11" version="1">MTRHTTILMCALGWLSGCATMSPVERAAALEAQNKQRVRQLTEELYNLRMLDRIPEFIAEDFVDRSQDAPLNAVGPAFIRQQAEASFKTFPELKFDILHLVADGDLVLAHWKATAPAPQPLLLQGHSLYRLRDGKVVESWDISDRLSPLLQRGYKVVPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYQ2</accession>
    <name>Q1CYQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556279.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6347"/>
    <dbReference type="EnsemblBacteria" id="ABF92831">
        <property type="protein sequence ID" value="ABF92831"/>
        <property type="gene ID" value="MXAN_6347"/>
    </dbReference>
    <dbReference type="GeneID" id="41363561"/>
    <dbReference type="KEGG" id="mxa:MXAN_6347"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_0_0_7"/>
    <dbReference type="OMA" id="YQGAVGH"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="403" mass="41767" checksum="8DED7FE9AE17A42E" modified="2006-07-11" version="1">MRPSSSPQGGLPSSPASPVDRATALRELAGLFLRLGTFAFGGPAAHIAMMEDEVVRRRGWLSREEFVDLLGATNLIPGPNSTELAIHIGHRRAGWPGLLVAGACFILPAFFMVAVIAWAYTRFGTLPKVDAVLHGVKAVIIAVVAQALWGLLRTVVRTPLAASVGAAAVAAAFMGVNELLLLLLSGLAVLAWRGMERQRPGAPRAGVAPLWPLLSLGVTTATAAAPFTLHGLFLFFVKVGSVLYGSGYVLLAFLRTGLVERYGWLTEAQLLDAVAVGQVTPGPVFTTATFIGYVMGGPSGAVVATAGIFLPAFVFVALSGPLVPRLRRSWVAGAFLDGVNVASLALMAVVTWQLGRAVLVSPLPVALAAVAAVLLIRYRVNSAWLVLGGGCVGVLAAGGLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYQ5</accession>
    <name>Q1CYQ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556276.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6344"/>
    <dbReference type="EnsemblBacteria" id="ABF86344">
        <property type="protein sequence ID" value="ABF86344"/>
        <property type="gene ID" value="MXAN_6344"/>
    </dbReference>
    <dbReference type="GeneID" id="41363558"/>
    <dbReference type="KEGG" id="mxa:MXAN_6344"/>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008530_1_0_7"/>
    <dbReference type="OMA" id="WQGGKRA"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="205"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="498" mass="51962" checksum="4FA62D7191C80DF7" modified="2006-07-11" version="1">MRPTSSLTWLSFITGATVMASEMAASRLMAPYFGSSTPVWAALISLVLGGLALGAHLGGRVADRSGRLTLLLSALCLSALALAMLPFLARVLLPGATAAVLGGRPIEGLGRVALLMVVAMPPLLVLGAVGPYVLRVGLAGVESAGAHAGRLSSASTVGSITGTLLAAFVVLPLLGTARTMALFAAVLGLTASWRLGWRWRLPAVGVPMVALALGAHALPRAPKAVDVAESPYAFIQVVKDEHGTRSLVFDEGYAVQSVHRPGLPVRGEVFGHYLLVPAMAQAAPRAPRVLVLGLGAGTSARGLRETYPGVEVVGVELDAEVVRLGRAHFDLPSEVEVHVGDARAFLASDTRQYDVILVDAFRFPYVPFHLTTREFAAAVAARLNPGGVACFNVGRYAQERAVVEAVGATLATVFPEVRAADARNHSNTLLFAGAPGLAERLAERTASLPASLRPLAERVAGELKPVPAGEPLTDDKAPVEWLTDAILLRALSSGEKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYQ7</accession>
    <name>Q1CYQ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine cleavage system T protein</fullName>
            <ecNumber evidence="4">2.1.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvT</name>
        <name evidence="4" type="ORF">MXAN_6341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.10" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556274.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6341"/>
    <dbReference type="EnsemblBacteria" id="ABF87273">
        <property type="protein sequence ID" value="ABF87273"/>
        <property type="gene ID" value="MXAN_6341"/>
    </dbReference>
    <dbReference type="GeneID" id="41363556"/>
    <dbReference type="KEGG" id="mxa:MXAN_6341"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_6_3_7"/>
    <dbReference type="OMA" id="RHHELGP"/>
    <dbReference type="OrthoDB" id="1984573at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="6"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="3">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="37860" checksum="6F22542EC50473D5" modified="2006-07-11" version="1">MEPLSLHFLHEKAGARFGAVGGRETVAGYGDSEGEYRAAKASVALHDASYRETLRITGEDRASYLHGMVTQEVNNLPVGTAAYAAMVTVKGAMVADARILKREPDLLLDLEPGTGAKVREFLDKYLISEDAELHEATGELALLRLLGPRTEDVLSAALGSPHAPLSHHAARTATLAGQEVWLLGSTAIEPHGVDVWVPRAGLEDAWRALSEAGAAHGLKPLGFEALELLRVEAGVPRYGQDMVDTTIPLEANLANAISYNKGCYIGQEVIARATFRGHMNRKLTGLLLGDADVAPGTELRRGEKKVGWLTSVVQSPVAGQRVALGYVHRDSLEPGTELTLAAGPATVKVASLPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYZ1</accession>
    <name>Q1CYZ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90822">
        <property type="protein sequence ID" value="ABF90822"/>
        <property type="gene ID" value="MXAN_6253"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6253"/>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486459_0_0_7"/>
    <dbReference type="OMA" id="LTEMHPV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="656" mass="72029" checksum="D3767C6A65D3D477" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYZ5</accession>
    <name>Q1CYZ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556191.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6249"/>
    <dbReference type="EnsemblBacteria" id="ABF87367">
        <property type="protein sequence ID" value="ABF87367"/>
        <property type="gene ID" value="MXAN_6249"/>
    </dbReference>
    <dbReference type="GeneID" id="41363471"/>
    <dbReference type="KEGG" id="mxa:MXAN_6249"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056341_0_0_7"/>
    <dbReference type="OMA" id="WLVHLLQ"/>
    <dbReference type="OrthoDB" id="250058at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="465" mass="51438" checksum="58965405FC8B2668" modified="2006-07-11" version="1">MTKFVKTGDDTPRLSLGTAAARQLATTTKTVPQMQGITPRWLLRMLPWVEVTGGTYRVNRRLSYAVADDRLVFSNIGAKVQVIPQELLKLPLLRGLSGDDEVIAALASQFTQAEYKAGDVIVEAGAPAEHVFLLAHGKARKLRAGPYGAPVTLDVLADGDHFGDQAVVESDDVWTFTVKATTPCTVLSLPQQVFEGLIARSATLRAQVERYRERLKKPQDKLGQAAIPLAAGHSGEPDIQGGYVDYELTPREYELSVAQTVLRVHTRVSDVFSDPMDQTEQQLRLTIEALRERQEHELINNRDFGLLHNADLKQRVHTRNGPPTPDDLDELLSRRRKSRFFLAHPRTIAAFGRECTRRGIYPTPIEVQGTPCMAWRGVPLLPCDKIPITEQRTSSILVLRTGQEDQGVIGLRRTGLPDEVEPGLSVRRMDVTDKAITNYLVSTYFSAALLIPDALGVLENVELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZV0</accession>
    <name>Q1CZV0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R2K_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555887.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5936"/>
    <dbReference type="EnsemblBacteria" id="ABF86221">
        <property type="protein sequence ID" value="ABF86221"/>
        <property type="gene ID" value="MXAN_5936"/>
    </dbReference>
    <dbReference type="GeneID" id="41363175"/>
    <dbReference type="KEGG" id="mxa:MXAN_5936"/>
    <dbReference type="HOGENOM" id="CLU_982509_0_0_7"/>
    <dbReference type="OMA" id="RWIVIEC"/>
    <dbReference type="OrthoDB" id="845510at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025643">
        <property type="entry name" value="R2K_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14243">
        <property type="entry name" value="R2K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R2K_3" evidence="1">
        <location>
            <begin position="136"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="32666" checksum="0F067C7EDA5834E3" modified="2006-07-11" version="1">MLRPGEDLLQVEERLWLLSAPTGQGTYDFAFDRFFACRRPYVLPESMEVVARVGVWNDYAERYRELAEAGIRLVHTPEQHLQATELPHWYPKLTDLTPRSVWFDERPDAETVERLLGWPVFVKGERQTSRHRKSLSIIEGPEQFRQAMAAYAKDPILHWQRVVCRELRPLRRVEEGAPDRIPSSFEFRTFWWKGQLVGWGPYWWQGTPYTLTPEAQREALGLGREVARRLDVPFLVVDVAQEVSGRWIVIECNDGQESGYAGISPFALWRAILDVERGTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D024</accession>
    <name>Q1D024_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sodC</name>
        <name evidence="8" type="ORF">MXAN_5862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="4">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555813.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5862"/>
    <dbReference type="EnsemblBacteria" id="ABF92167">
        <property type="protein sequence ID" value="ABF92167"/>
        <property type="gene ID" value="MXAN_5862"/>
    </dbReference>
    <dbReference type="GeneID" id="41363101"/>
    <dbReference type="KEGG" id="mxa:MXAN_5862"/>
    <dbReference type="eggNOG" id="COG2032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_8_1_7"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015673at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0186">Copper</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187946" description="Superoxide dismutase [Cu-Zn]" evidence="6">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="7">
        <location>
            <begin position="62"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="20120" checksum="56E759504D3CE819" modified="2006-07-11" version="1">MPQEEDTLMKIRALLTAAALTAALPALAQEGAGTPPPADKKTQPKGQTAKAQVKDSEGKDVGEITLEQTKQGVLIKGKLSNLPPGQHAFHIHEVGKCEGPAFTTAGGHFNPTKKAHGLLAPKGKHQGDLPNLYVAQDGTVQFDIFSQNGLTLKSLFDKDGSAVVVHAKEDDYHTDPAGDAGGRIACGVVEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D059</accession>
    <name>Q1D059_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555778.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5827"/>
    <dbReference type="EnsemblBacteria" id="ABF92598">
        <property type="protein sequence ID" value="ABF92598"/>
        <property type="gene ID" value="MXAN_5827"/>
    </dbReference>
    <dbReference type="GeneID" id="41363067"/>
    <dbReference type="KEGG" id="mxa:MXAN_5827"/>
    <dbReference type="eggNOG" id="COG2718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049702_2_0_7"/>
    <dbReference type="OMA" id="QYFAYIE"/>
    <dbReference type="OrthoDB" id="481720at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="41865" checksum="25ABFD6F852408FA" modified="2006-07-11" version="1">MTLKIHQDHSRFKQIVRGKIKANLRKYVQKGEMIGKKGKDAISIPIPFIDIPRFKYGHKEQGGVGQGDGDVGQQLGPGAVEPGEGKQAGQGEGDHAMEVDVTLDELAQILGEELQLPNIERRQNERIITQKIRYTGVNTTGPESLRHFKRTFKQALRRQIAAGTYDPARPVIIPTREDRRYRSYKLQDLPETNAVIIYMMDVSGSMGDEQKEIVRIESFWLDTWLRHQYKGLEARYIIHDAVAREVDRDTFFHTRESGGTMISSAYKLCRDIILADYPKSAWNIYPFHFSDGDNWSADDTRQCIEMLRNDVLPNVNQFAYGQVESPYGSGQFIKDLREAVGDTPNVALSEIADKDAIYASIKDFLGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0P0</accession>
    <name>Q1D0P0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III secretion protein, FlhB/HrpN/YscU/SpaS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555598.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5644"/>
    <dbReference type="EnsemblBacteria" id="ABF93163">
        <property type="protein sequence ID" value="ABF93163"/>
        <property type="gene ID" value="MXAN_5644"/>
    </dbReference>
    <dbReference type="GeneID" id="41362890"/>
    <dbReference type="KEGG" id="mxa:MXAN_5644"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_1_3_7"/>
    <dbReference type="OMA" id="YYMSHIS"/>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="38003" checksum="E2D0C0C437DB4A67" modified="2006-07-11" version="1">MSGEKTEKPSAKRLREARRKGQIPRSRLLNASAVTAGGLFGLTAAAPVGMARLQAWTEHLFLGQQDLGAWQEGLWIAARFCGPVLGGAFAAALLVSVATVGLEADLQHVEPKLERISLVAGMQRLFSWRPWVELAKTLLIVCLVGALVWSDVEEAAPDAMKTAWLGGAEGLSLAVAHVSGLASRLACLLVVLGVGDYALAWRRHIKDLMMTREEMKREYKDSEGDPRHKGQRKALHRQLAQGGAARGVQKATAVVVNPTHIAVALRYDVDECEAPYLVAKAREGDARAMREQARRLGIAVVRDIPLARSLIHYDVGEPIPEELYQAAAVVLRTAMDARELDGHPRRQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R5</accession>
    <name>Q1D0R5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5619"/>
    <dbReference type="EnsemblBacteria" id="ABF87094">
        <property type="protein sequence ID" value="ABF87094"/>
        <property type="gene ID" value="MXAN_5619"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5619"/>
    <dbReference type="HOGENOM" id="CLU_066417_0_0_7"/>
    <dbReference type="OMA" id="VWLAHPD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="357" mass="38220" checksum="9BAF0890F5067C31" modified="2006-07-11" version="1">MYHGVGKTPLREKSVDCDSTMGVPLPTSRDIHHHGGARGVVGAGGQGRTPKDARSARHLSMRHHQRRWMAATWVERHVRMVRGMYAATQALAVVLLVVVGAGCREEKQAEPLKSLKPEPLPSLTVPGEAAPEAPRPASPSEVEVAGPIHGEPLPASALRVALAGERVRVGEEAFEPARPDDAARLARRVKGHTVLVVPDADTFLVQTSELFTVLRDSAESVWLAHPDGPVAYPVVLRDEAGFRAWLEEVAPGKLRIIMRADGFELTTSVGKLPGPDPNGPSVPVRAGRQDIVTLRRGLGLLKGRFKTSEDICLVPSFGTEVAQAARALGGNFTAPGEPLFDTLCFVYPTPHKAPDGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0S0</accession>
    <name>MRAZ_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">MXAN_5614</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555568.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0S0"/>
    <dbReference type="SMR" id="Q1D0S0"/>
    <dbReference type="STRING" id="246197.MXAN_5614"/>
    <dbReference type="EnsemblBacteria" id="ABF92659">
        <property type="protein sequence ID" value="ABF92659"/>
        <property type="gene ID" value="MXAN_5614"/>
    </dbReference>
    <dbReference type="GeneID" id="41362860"/>
    <dbReference type="KEGG" id="mxa:MXAN_5614"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_5_7"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000062905" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="150" mass="16994" checksum="82190A5175CB0D02" modified="2006-07-11" version="1">MFRGVYEHQIDAKGRTSLPAKLRDTLVGAYDERLILTTALDRCLHAYPVREWEALELSLAKRNPMEPGVKTLMRLYVASAQECPLDKLGRLLIPPTLRSYAGLEKEVVWAGMVKVIELWSREGWAKAQEEARQEATSADVMKVLAELRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D141</accession>
    <name>Q1D141_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rpiA</name>
        <name evidence="3" type="ORF">MXAN_5489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555447.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5489"/>
    <dbReference type="EnsemblBacteria" id="ABF86071">
        <property type="protein sequence ID" value="ABF86071"/>
        <property type="gene ID" value="MXAN_5489"/>
    </dbReference>
    <dbReference type="GeneID" id="41362743"/>
    <dbReference type="KEGG" id="mxa:MXAN_5489"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_7"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="1681738at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="24215" checksum="05C3E06D441E0504" modified="2006-07-11" version="1">MSQQGDGAATARYKQAAAEWAVDGFLQPGMVVGLGTGSTAAFAVQRLAALRAQGRLLDIVGVPTSRATEALARSLGVPVSTLDAHPVLDVTLDGADEVAPDLSLIKGGGGALLREKIVAQASRRVVIVVDAGKLSPVLGTHWPVPVEVMSFGWRSQARFLESLGARVTVRQGAGGEPFLTDQGNLVLDCAFGPIDAPAALAASLGARAGIMGHGLFLNLATDLVVAGPEGVEHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H6</accession>
    <name>Q1D1H6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555312.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5347"/>
    <dbReference type="EnsemblBacteria" id="ABF87751">
        <property type="protein sequence ID" value="ABF87751"/>
        <property type="gene ID" value="MXAN_5347"/>
    </dbReference>
    <dbReference type="GeneID" id="41362616"/>
    <dbReference type="KEGG" id="mxa:MXAN_5347"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1179200_0_0_7"/>
    <dbReference type="OMA" id="HHDGWRV"/>
    <dbReference type="OrthoDB" id="1268089at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25223" checksum="892C554CF08D9460" modified="2006-07-11" version="1">MPYPLDDATATALIALHPWVLTRSPQAPVQAAVEVLVQAEQARRGQPDAKTGALQVPALTQGNLLKEEYDLSTHGHHDGWRVGAVIADVQGMINVNARFGFPTGDAVLRATVESLSAQYPGAKVVRIHADAFAALLVPTSQLTVEEHLAAPTRERLAQGVRPVLPPGTPDADVPSWTVSLLELTVDAPSHWQVLGPLLWAELERTHVMERTGRAQGLQRRRIRLDGSIPGPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W7</accession>
    <name>Q1D1W7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">dnaG</name>
        <name evidence="15" type="ORF">MXAN_5203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D1W7"/>
    <dbReference type="STRING" id="246197.MXAN_5203"/>
    <dbReference type="EnsemblBacteria" id="ABF86125">
        <property type="protein sequence ID" value="ABF86125"/>
        <property type="gene ID" value="MXAN_5203"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5203"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_7"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="14">
        <location>
            <begin position="256"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF86125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="606" mass="66847" checksum="98DE8768516104A2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X3</accession>
    <name>Q1D1X3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5197"/>
    <dbReference type="EnsemblBacteria" id="ABF91787">
        <property type="protein sequence ID" value="ABF91787"/>
        <property type="gene ID" value="MXAN_5197"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5197"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064945_0_0_7"/>
    <dbReference type="OMA" id="CYCGCPH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="67"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="29679" checksum="BB63F63A5D743DE1" modified="2006-07-11" version="1">MDPATAVSGIPGMDFSSLSPTAKRELATVFNDEFCYCGCPHTLGACLKSHTPCKHARRMAQLAARRVSEGSPATEVILSLSTYYSAFRDPRAQFKVDDRMCMGPAGAPVTVVEFSDFECPYCAKARPVLEAFAKKHAQQVRFCYLPFPLSMHANAKPAAQAALWARDQGKFWQMHDALFEHQSNLKPDAIAALATSLGLDGAKLAALLKTDAYKEELDGYRSQGRAAGISGTPSVYFNGRALDLSFVEAEMLSHSLEDELEWSANKNAWAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Z3</accession>
    <name>Q1D1Z3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555148.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5177"/>
    <dbReference type="EnsemblBacteria" id="ABF88698">
        <property type="protein sequence ID" value="ABF88698"/>
        <property type="gene ID" value="MXAN_5177"/>
    </dbReference>
    <dbReference type="GeneID" id="41362460"/>
    <dbReference type="KEGG" id="mxa:MXAN_5177"/>
    <dbReference type="HOGENOM" id="CLU_2899463_0_0_7"/>
    <dbReference type="OMA" id="KYPPQPV"/>
    <dbReference type="OrthoDB" id="2014223at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="66" mass="7370" checksum="7B04AB51EFE6EE1B" modified="2006-07-11" version="1">MTTPPPESLPFPDSLCHRCAAPPRYVQSRTTTFILCPLLPQKYPPQPVRACALFKPKPPETPPVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Z7</accession>
    <name>Q1D1Z7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555144.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5173"/>
    <dbReference type="EnsemblBacteria" id="ABF86661">
        <property type="protein sequence ID" value="ABF86661"/>
        <property type="gene ID" value="MXAN_5173"/>
    </dbReference>
    <dbReference type="GeneID" id="41362456"/>
    <dbReference type="KEGG" id="mxa:MXAN_5173"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577248_0_0_7"/>
    <dbReference type="OMA" id="HERMYLL"/>
    <dbReference type="OrthoDB" id="967932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="473" mass="52738" checksum="F040D744DB647256" modified="2006-07-11" version="1">MQFQDAFTFPTPLSPETEASARELLRAQQMGQLDLLMGWVQQPERLGKLGGCATELQSLLSEAFELVERAPALAREFLEHWSTTVLLGRLLGPAAVGPGLIQCLMGNLASLLIVQRLRGEVTHGEAFFVTPRTLYCLPRGERLDVRGPGEGRVVWHFSGAECLLSVEGHSGPGLRIPLPLMGDAPVSIQPLPWSETWNVPVLDDSEMLGITGRRDQAGIPDDGSTGTWRPMPLLQSTEEAFHILGKLWPEVLDWARVLLPALVDMGGPENRSVRCSSSYGAGTPVFLTRVANGLEHAEDLVHELQHERMYLLLDSRAFGRWDDSRPEFVSAYRTDPRPLRGVHLGLHSFLAVNRLRLLALDRPEFKQREWRFQLLKSHRCNLLSFRTLLDFERPTPEGRVLLAQMAQALSEQHPLIERVADADMDQAFDTWMKQHFSRVAASGPVVNDAETYMGWREAAVLAARYTQHAGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2I7</accession>
    <name>Q1D2I7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formamidopyrimidine-DNA glycosylase H2TH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4980"/>
    <dbReference type="EnsemblBacteria" id="ABF90790">
        <property type="protein sequence ID" value="ABF90790"/>
        <property type="gene ID" value="MXAN_4980"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4980"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1711277_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16430" checksum="6FBFDF729B0F4E53" modified="2006-07-11" version="1">MGISVARGQAPAPCMCGGDVRVAEVPEVEIITRDLRQAVVVGNRDADESLWQAGIAPRRLASSLTADEVVRLDRAIQAVLDEGLRMRGTQRDLFGVQGQAKHRRNVFGRAGAPCPRCATPVSHQRIGGRNTYWCSSCQPLASAPEVPAQSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2V4</accession>
    <name>Q1D2V4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554844.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4860"/>
    <dbReference type="EnsemblBacteria" id="ABF89142">
        <property type="protein sequence ID" value="ABF89142"/>
        <property type="gene ID" value="MXAN_4860"/>
    </dbReference>
    <dbReference type="GeneID" id="41362153"/>
    <dbReference type="KEGG" id="mxa:MXAN_4860"/>
    <dbReference type="eggNOG" id="ENOG50319TQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899617_0_0_7"/>
    <dbReference type="OMA" id="ICQCSTD"/>
    <dbReference type="OrthoDB" id="1178142at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="33461" checksum="C2D96B330F110D24" modified="2006-07-11" version="1">MVVGACSQWPEAPRAAFQTRGNLNMQLRKMMLVLTALGAMSGLMAGCGDDSTSPGACTSNDECGESEICHPTAQVCVQTCNSGSDCPSTAKTCAPLGGTSTTSICQCSTDVLCNGGTDSESTGLVCSNLDNVCVTACTSDTECTGDRTCNVSTGQCEEGDTGPASCTGEGLSTCAYGQICSSGTCSAPPAPTCQNYKDFPNKADLGTTGPIIYKVGFVNATTDTAFCPANLPKRLRIRINAYSNTPFPDTSTELSRFFYVQTDGGRLNASISRSEGNYIVTGANRSNAEIIVNLCVAATSTTNSAGFYFSDGNFVCHQSNYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D335</accession>
    <name>Q1D335_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554763.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4776"/>
    <dbReference type="EnsemblBacteria" id="ABF89967">
        <property type="protein sequence ID" value="ABF89967"/>
        <property type="gene ID" value="MXAN_4776"/>
    </dbReference>
    <dbReference type="GeneID" id="41362075"/>
    <dbReference type="KEGG" id="mxa:MXAN_4776"/>
    <dbReference type="eggNOG" id="ENOG50316NU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1576817_0_0_7"/>
    <dbReference type="OMA" id="DCNPSIA"/>
    <dbReference type="OrthoDB" id="1536418at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="17340" checksum="603A78BDD6A4514F" modified="2006-07-11" version="1">MSLRLLSPLLLLGLGACGPDAEPAGRFPLALTMERAVANDVQALQVAVVSRGSSRSCTEIQRTCLGTQVRRDDLVVLKDAQGREGRALRFPVDLATLQSGGSLELAVDVPVGRDYALVIEAITTGTPPGFLGSSCNYLREVNAGDNAPVIAAPLTLTGGDCNPSIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3G7</accession>
    <name>Q1D3G7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_4640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554632.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4640"/>
    <dbReference type="EnsemblBacteria" id="ABF93051">
        <property type="protein sequence ID" value="ABF93051"/>
        <property type="gene ID" value="MXAN_4640"/>
    </dbReference>
    <dbReference type="GeneID" id="41361940"/>
    <dbReference type="KEGG" id="mxa:MXAN_4640"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340583_0_0_7"/>
    <dbReference type="OMA" id="VQPLICQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="333"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="567"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="11">
        <location>
            <begin position="734"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF93051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="836" mass="92000" checksum="AEEA83CA74146843" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D444</accession>
    <name>Q1D444_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554407.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4407"/>
    <dbReference type="EnsemblBacteria" id="ABF91820">
        <property type="protein sequence ID" value="ABF91820"/>
        <property type="gene ID" value="MXAN_4407"/>
    </dbReference>
    <dbReference type="GeneID" id="41361720"/>
    <dbReference type="KEGG" id="mxa:MXAN_4407"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_449651_0_0_7"/>
    <dbReference type="OMA" id="PIRAWSG"/>
    <dbReference type="OrthoDB" id="268105at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="685" mass="75251" checksum="715DD9C677EC724D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D473</accession>
    <name>Q1D473_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4377"/>
    <dbReference type="EnsemblBacteria" id="ABF85901">
        <property type="protein sequence ID" value="ABF85901"/>
        <property type="gene ID" value="MXAN_4377"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4377"/>
    <dbReference type="HOGENOM" id="CLU_2480115_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="87" mass="9620" checksum="848DBB32CC8B2E6A" modified="2006-07-11" version="1">MLPRMMGRLPPVEPAPCCLSGLIFEVFELAFRYLSVVRHHFDGEHIPHFLAGAVEVASLLVAIHPVQRVHQPVGPVGDAPRTLAEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4E6</accession>
    <name>Q1D4E6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554305.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4302"/>
    <dbReference type="EnsemblBacteria" id="ABF89221">
        <property type="protein sequence ID" value="ABF89221"/>
        <property type="gene ID" value="MXAN_4302"/>
    </dbReference>
    <dbReference type="GeneID" id="41361613"/>
    <dbReference type="KEGG" id="mxa:MXAN_4302"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331159_0_0_7"/>
    <dbReference type="OMA" id="ERSVAIC"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="847" mass="95717" checksum="CE21F3E8C5CE34A8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F3</accession>
    <name>Q1D4F3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554298.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4295"/>
    <dbReference type="EnsemblBacteria" id="ABF88911">
        <property type="protein sequence ID" value="ABF88911"/>
        <property type="gene ID" value="MXAN_4295"/>
    </dbReference>
    <dbReference type="GeneID" id="41361606"/>
    <dbReference type="KEGG" id="mxa:MXAN_4295"/>
    <dbReference type="eggNOG" id="COG3621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_144_9_7"/>
    <dbReference type="OMA" id="QCRMILR"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="359" mass="39323" checksum="F9D5DE12C71235E7" modified="2006-07-11" version="1">MPHRVLAMDGTSISGGEGYVTAGLLKSLKETLTSRGGGQSLLNDVELFSGTSAGSFNAAFFATYENPDDAFPKILDFWGEVVQMNRKAVSLGRTAMALTGNAALLDSSYMRDFFCSYFGATLRLGDLKRKVALPSFQLDGHRKSLRTWKAKIFHNTGPDNDSDHNELVVDVLMRSGSPPLSYPVYQGIREQGSGYVDGGIFANNPSLVALAQIINNITRKSRTEKVETLETEPPDLTNILMMSVGNGCMSSYLTPHFCKGVANWGFSKWLLDFHDPMVLVKMMLEAGSDAADYQCRMILRKKYFRLNPVVDQTLSAANLKQVESTVQSLLSTQSTVSQLNRAQTWLGKSGWVSDAAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4J5</accession>
    <name>Q1D4J5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554256.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4253"/>
    <dbReference type="EnsemblBacteria" id="ABF88100">
        <property type="protein sequence ID" value="ABF88100"/>
        <property type="gene ID" value="MXAN_4253"/>
    </dbReference>
    <dbReference type="GeneID" id="41361568"/>
    <dbReference type="KEGG" id="mxa:MXAN_4253"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="LMTTGRY"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="14196" checksum="1E59BEA87F209C51" modified="2006-07-11" version="1">MRARSVAQNILIVDDESSLCWVLGQFFSGAGYRVDSAGALDEALDLMTTGRYDLVISDLRLSGTLSEEGLMLADFVRRYTPQTRVVLLTAFATQELTDRAQALGVDLVLSKPQPLPTLAEHVSRLLAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4W4</accession>
    <name>Q1D4W4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3814"/>
    <dbReference type="EnsemblBacteria" id="ABF87023">
        <property type="protein sequence ID" value="ABF87023"/>
        <property type="gene ID" value="MXAN_3814"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3814"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622164_0_0_7"/>
    <dbReference type="OMA" id="ENELTWW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="49806" checksum="7D3F24156DACD2B1" modified="2006-07-11" version="1">MNKDAKDGVNQVSTPRSASRLLGRVIAVMLLTVLGGCRKSDAERAAQEREEIEARIRDAYSLVPYRALKLTMRAEGQPNAPAEIAALWQTLADTRDLPAKAASEEEALRVAKAYLDLGVAFYKAKKTLEQRDEDEFPLLWNRFQPDQQPPLPGYDAGQEHAFLSALWFVLDAADSGNRVPATDLVLYELSRATLQPAWPPGLRVSVRGSRGMAFCGAGYHYAAEEELNAFLSEAEAMPASDFPAMREAAPAQVRETLLATGYFLRAWNRMGLKRERAAEDDLERGLGSLEKLGIENELTWWGWAFIHFRRERYDESARYLDTLAKSPYLGETERRDLQASADAMRKHGERLPIFLQARAAAILGQALVARAGGPEKILVTLLGPERAGQVLAPILWMDRVRQGLAQRSMDDIARAAGDSFEGVRAAGSKGLSALKEKLLGGGGDTKTAAESPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D616</accession>
    <name>Q1D616_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553738.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3721"/>
    <dbReference type="EnsemblBacteria" id="ABF90757">
        <property type="protein sequence ID" value="ABF90757"/>
        <property type="gene ID" value="MXAN_3721"/>
    </dbReference>
    <dbReference type="GeneID" id="41361054"/>
    <dbReference type="KEGG" id="mxa:MXAN_3721"/>
    <dbReference type="eggNOG" id="COG3215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136808_0_0_7"/>
    <dbReference type="OMA" id="LLRCWCE"/>
    <dbReference type="OrthoDB" id="1917973at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="13685" checksum="43BA6BD6AEF8EB00" modified="2006-07-11" version="1">MTEEGSGLSENRKSTRIPTQLRCWCEGDNVTLYARISNLSEGGLFLRTSTPLARGARTVVKLSPAGHQDIQAQATVVWLREAEERALPAGMGLRFESLDSDTLGRLRQMISQQQQNQVKVGWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L0</accession>
    <name>Q1D6L0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltA</name>
        <name evidence="9" type="ORF">MXAN_3519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553549.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3519"/>
    <dbReference type="EnsemblBacteria" id="ABF91073">
        <property type="protein sequence ID" value="ABF91073"/>
        <property type="gene ID" value="MXAN_3519"/>
    </dbReference>
    <dbReference type="GeneID" id="41360863"/>
    <dbReference type="KEGG" id="mxa:MXAN_3519"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_0_0_7"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="433" mass="48897" checksum="2066EE4C47C73143" modified="2006-07-11" version="1">MAKDTLTITDNRTGKTYEVPIENGCIRTNALRQIKTGDDDFGLMGYDPAFLNTANCKSAITFIDGDKGILEYRGYPIEQLAEKSSFLEVAYLLLNGELPSEKELQQFNHLVTHHTYVHENVKSFMDGFRYDAHPMSMVSSTVAALSSFYPDAKNIKDPLSRRIQITRLIAKMPTIAAFSYRHTMGLPYIYPDNDLSYVANFLAMIKRIGTSTYKVHPVLERALDILFILHADHEQNCSTTSVRTVGSSEVDPYSAVSAGIGALYGPLHGGANEAVLRMLRDIGHVSKIPEFIKSVKSGEGEKKLMGFGHRVYKSYDPRAKVIKRVADEVFEVTGKNPLLEIAVELERIALEDEYFVKRKLYPNVDFYSGLIYEAMGFQVEMFPVLFAIPRTVGWCAQWEEMVTDNEQKIARPRQVFTGAPRRDYVPMDKRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N1</accession>
    <name>Q1D6N1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA nucleotidyltransferase/poly(A) polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553528.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3498"/>
    <dbReference type="EnsemblBacteria" id="ABF88986">
        <property type="protein sequence ID" value="ABF88986"/>
        <property type="gene ID" value="MXAN_3498"/>
    </dbReference>
    <dbReference type="GeneID" id="41360843"/>
    <dbReference type="KEGG" id="mxa:MXAN_3498"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_3_1_7"/>
    <dbReference type="OMA" id="TMNAMAY"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="263"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="422" mass="45457" checksum="B070FAAE8C40B22A" modified="2006-07-11" version="1">MIANLHNADIPQPVLDVIARLRDLGHAVYLVGGCVRDMVRLVHPKDFDVATSALPQEVQGAFRKVIPTGIQHGTVTVLQNGTHVEVTTFRSEGDYLDGRRPSSVAFERDIVKDLSRRDFTINAMAYNPLDRELVDPFGGQSDLRSQLIRCVGSAQERFSEDGLRPLRAVRFAAVLGFALDSATRAAIPATLGVFRKVALERVREELVKLLLSPRAESGLLLLADTGLLDVFLPELARAEASAAASVRAAVQASPLEVEVRVAVLLADLVDRAQARDIGLRLKFPNKVADLVALLVEHAKAETRVGEPDAALRRLLARLGPPQLPLWAAVVRARVGVRQPDALPAVEALIARVEALAAAKPPLTAKDLSLTGGDIMAALGVGPSPIVGEATRFLVESVLDDPSLNTADALRQRLQAWQAQVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P9</accession>
    <name>Q1D6P9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553510.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90809">
        <property type="protein sequence ID" value="ABF90809"/>
        <property type="gene ID" value="MXAN_3479"/>
    </dbReference>
    <dbReference type="GeneID" id="41360826"/>
    <dbReference type="KEGG" id="mxa:MXAN_3479"/>
    <dbReference type="eggNOG" id="ENOG5033RQ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065345_0_0_7"/>
    <dbReference type="OMA" id="YMQSPND"/>
    <dbReference type="OrthoDB" id="335428at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188270" evidence="2">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="362" mass="39487" checksum="59FF8EFEAA6B6892" modified="2006-07-11" version="1">MTRNRFLSSTCGALFALAAITGCGNEAGNEDSNAPGRTETPGQSPQVPAPSPSEQTPGGQTPGTPEPGDSDTSPDEPVATTPPDEPSTHPENPSTEPEQPVASGADKFGVTMIHPSAAGGEQWFLADDAMSDSRFDPQDDLTRNSDGSWNLKSDKVRMNVFTSTGYKPKEIATYDRDVLASRGYMQSPNDWKNIEMTGFVKLNSASDESDNFDMYARGGKHNDDHEGCEGSSYKGALHFNGQARFQKEAWHVSYEQAPYKKVTEPLTGRWVGFKTVMRNTQVNGKEAVHLEMYLNENADKVSWEKVYDFVDAGDWGGDAEHCGGADGAIPLTWGGPIATFRWDSTDDVDFKWLSVREIAPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6R7</accession>
    <name>Q1D6R7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3459"/>
    <dbReference type="EnsemblBacteria" id="ABF87111">
        <property type="protein sequence ID" value="ABF87111"/>
        <property type="gene ID" value="MXAN_3459"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3459"/>
    <dbReference type="eggNOG" id="COG3791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116419_0_0_7"/>
    <dbReference type="OMA" id="LEGSCQC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="18771" checksum="F83BF11D671FFA4B" modified="2006-07-11" version="1">MMKLEGSCHCRGVRFSVETHHPSPFMRCYCSVCRKTQGGGGFAINLSGDARSLKVRGRQHVKVYRARIQNPEDAKAHQSKGQRHFCGRCGSALWLYDPRWPELIHPFASAIDTPLPEAPELVHIMLEFKPDWVPVHAGKKDKKFQRYPKESIAEWHQRHDAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Y7</accession>
    <name>Q1D6Y7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD/FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553422.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3389"/>
    <dbReference type="EnsemblBacteria" id="ABF87415">
        <property type="protein sequence ID" value="ABF87415"/>
        <property type="gene ID" value="MXAN_3389"/>
    </dbReference>
    <dbReference type="GeneID" id="41360736"/>
    <dbReference type="KEGG" id="mxa:MXAN_3389"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_7"/>
    <dbReference type="OMA" id="YRFSQWK"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="3"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="39550" checksum="362A636045C7ECEB" modified="2006-07-11" version="1">MTDLFAPLELRKSVIAPNRIWLAPLTNTQSHPDGTLSDAELRFLAMRADGGFGMVETCAAYVSQDGKTWPGELGVHDDAMLPGLKRMAARIHEGGALLSAQLFHGGLRANAEVSQREVWSASAYDADGLHCREATEADIEGVIAAFANAARRCAEAGFDAVELHGAHGYLFSQFLSTVFNRRQDRWGGSLENRWRLLQETVRAVRRAAPSLVLAVRLSPEDARQARGLDLDESLEVARMLTREGVDILHLSLWKAAHNTLKRPDQHATPLFRQAVGTGVRIVVAGEVRTREEAEAQLARGADAVAVGRAAIANHDWPRRVQRGDALQVPPLSPTTLNAEGLSDVFVNYMRNWRGFVTDQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D9</accession>
    <name>Q1D7D9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c-type biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Possible subunit of a heme lyase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CcmH/CycL/Ccl2/NrfF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553280.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3235"/>
    <dbReference type="EnsemblBacteria" id="ABF88850">
        <property type="protein sequence ID" value="ABF88850"/>
        <property type="gene ID" value="MXAN_3235"/>
    </dbReference>
    <dbReference type="GeneID" id="41360589"/>
    <dbReference type="KEGG" id="mxa:MXAN_3235"/>
    <dbReference type="eggNOG" id="COG3088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107187_2_1_7"/>
    <dbReference type="OMA" id="MIAADMR"/>
    <dbReference type="OrthoDB" id="1984854at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005616">
        <property type="entry name" value="CcmH/CycL/Ccl2/NrfF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038297">
        <property type="entry name" value="CcmH/CycL/NrfF/Ccl2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03918">
        <property type="entry name" value="CcmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011022458" description="Cytochrome c-type biogenesis protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="18686" checksum="4B315F21937D1828" modified="2006-07-11" version="1">MTAALLSLSLAFTLVTGQFAPQQAGSDPLAPELETRAQTLGKQLRCAVCQGLSVADSPSSMARAQLDMIRELVSEGKSDAEIVEYFVARYGEWVLLSPRAEGFNWFVWLGPVGLVAVGAFVIWRQLQRGAGTPEQTPPAATTSEETAAPAAPAGTPPVDEEDPYLQAVRRELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H6</accession>
    <name>Q1D7H6_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3196"/>
    <dbReference type="EnsemblBacteria" id="ABF93116">
        <property type="protein sequence ID" value="ABF93116"/>
        <property type="gene ID" value="MXAN_3196"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3196"/>
    <dbReference type="HOGENOM" id="CLU_3357239_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="36" mass="4115" checksum="0EB0966C8F40B3BF" modified="2006-07-11" version="1">MERIQPLPEVREAPGEHAQRPLSASTCRPRESRVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U1</accession>
    <name>Q1D7U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553129.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3079"/>
    <dbReference type="EnsemblBacteria" id="ABF89448">
        <property type="protein sequence ID" value="ABF89448"/>
        <property type="gene ID" value="MXAN_3079"/>
    </dbReference>
    <dbReference type="GeneID" id="41360441"/>
    <dbReference type="KEGG" id="mxa:MXAN_3079"/>
    <dbReference type="HOGENOM" id="CLU_1710160_0_0_7"/>
    <dbReference type="OMA" id="SRQDWNL"/>
    <dbReference type="OrthoDB" id="1623305at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="19743" checksum="5A44F7D2D726A8A9" modified="2006-07-11" version="1">MKAGIGEDGMATTKTETEATQNEVQSSEAAAKSGLAQNVESFLKAQISQAQKRIEELEGEAGKVVKTLESRGQEAAKEAQALWAKFQAGELLTDPRVQELSKRANEASTELSRRVDAAGTELRKRFDGIQTRVVEAVGVASQAQLKDLNKELAKLSRKVDSLLKPVRRVNGAKPASSPASSPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7V8</accession>
    <name>Q1D7V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, haloacid dehalogenase-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553112.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3057"/>
    <dbReference type="EnsemblBacteria" id="ABF89668">
        <property type="protein sequence ID" value="ABF89668"/>
        <property type="gene ID" value="MXAN_3057"/>
    </dbReference>
    <dbReference type="GeneID" id="41360419"/>
    <dbReference type="KEGG" id="mxa:MXAN_3057"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_18_0_7"/>
    <dbReference type="OMA" id="EGSGRHK"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="24781" checksum="0020B76666F215D5" modified="2006-07-11" version="1">MGAMRPTVLLFDIDGTLVTTGGAGRRSMEAAFEKLHGRRDACDSFPMSGMTDRAIVRKAMHIIGVEDSAAAIDAVIDAYVAHLAEEVHKVDDQRYLVFPGMREAVKEARSRSGFAVGLGTGNVREGARVKLERVSIYDQFDFGGFGCDNEDRTELIRCGAKAGAAKLGVPVEECRVVVIGDTPKDVHAAQGVGAECIGVGTGTFSVQALLDAGATVAFPDFSHPQALEILLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D824</accession>
    <name>Q1D824_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553046.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2990"/>
    <dbReference type="EnsemblBacteria" id="ABF90829">
        <property type="protein sequence ID" value="ABF90829"/>
        <property type="gene ID" value="MXAN_2990"/>
    </dbReference>
    <dbReference type="GeneID" id="41360352"/>
    <dbReference type="KEGG" id="mxa:MXAN_2990"/>
    <dbReference type="eggNOG" id="ENOG5031DIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2700903_0_0_7"/>
    <dbReference type="OMA" id="VWAWIRM"/>
    <dbReference type="OrthoDB" id="2085895at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="8310" checksum="E309BECCC8C6A438" modified="2006-07-11" version="1">MVWAWLRMVMMVAVVLLPGGFPLLLTYVALRTLRSSWRRAQEEAQTGGRVVSLRDVVSTLHFKELVREARAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D892</accession>
    <name>Q1D892_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552980.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2920"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90185">
        <property type="protein sequence ID" value="ABF90185"/>
        <property type="gene ID" value="MXAN_2920"/>
    </dbReference>
    <dbReference type="GeneID" id="41360288"/>
    <dbReference type="KEGG" id="mxa:MXAN_2920"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_6_7"/>
    <dbReference type="OMA" id="VKFLDYV"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="42414" checksum="2AC87CE95318CD53" modified="2006-07-11" version="1">MPARPPWRPHVWYAEAVAHVLLDLRMVRGRLHGIARYALELARRMPVLAPDLHFSALVPPEGLAPDLGALTPRMPLHRALAGFLSPLEQPALAADLVKLAPDAFHATSFSLPLFWNGRLVATLHDANHLALADQYTPAQSIYYRVVVGPRAKRATALVTVSEFSRDELAKHLKLSPYRLQVIHNGVDARFQPPTQAEAAAFRERYELPARYVAAVGNAKRFKNLALLKDFAGELPVPVVLLAGKGAVAHELGLHENVVDLEELPEDQMPLFYGAASALLLPSRYEGFGLPALEAMGAGCPVLASDTTALPEVVGNAALRLSPDDAAAWREATLRVLRDDVLSRELVELGRERVARFTWDDCARRTLAVYRRVLEAPAPGGSRGTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D8</accession>
    <name>Q1D8D8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552935.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90153">
        <property type="protein sequence ID" value="ABF90153"/>
        <property type="gene ID" value="MXAN_2874"/>
    </dbReference>
    <dbReference type="GeneID" id="41360243"/>
    <dbReference type="KEGG" id="mxa:MXAN_2874"/>
    <dbReference type="HOGENOM" id="CLU_153840_0_0_7"/>
    <dbReference type="OMA" id="MWIEAIV"/>
    <dbReference type="OrthoDB" id="1654414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="149" mass="16558" checksum="6D1D1D80F5F34B8F" modified="2006-07-11" version="1">MPWGRACPTLECEPKGAQPARAMSDNPQTHPRTGSVEGDAMWIEAIIMPRQSATPYRPAPRKKRGADAIPASAPDRRPAYQAALDEGRRFWDAVLAFLKAHHLMDAVRWISEPGTIPLVTLHCTRIVLERLRQAPEFEAGLSMNLEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8E7</accession>
    <name>Q1D8E7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552926.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2865"/>
    <dbReference type="EnsemblBacteria" id="ABF86614">
        <property type="protein sequence ID" value="ABF86614"/>
        <property type="gene ID" value="MXAN_2865"/>
    </dbReference>
    <dbReference type="GeneID" id="41360234"/>
    <dbReference type="KEGG" id="mxa:MXAN_2865"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717484_0_0_7"/>
    <dbReference type="OMA" id="FWPRRDL"/>
    <dbReference type="OrthoDB" id="771299at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188362" evidence="2">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="392" mass="42097" checksum="5B910D56D6DDCAEA" modified="2006-07-11" version="1">MRRVLIAVATLASTPALAAPDWLQPVLVGEIDWRQHVSEVEGFDGVTLARLRVGARAYPVPWLMASGVAEWAQEKPALIDAFVAATLGESLRLSMGMSKTPLFISARDESQEARAIPELSLLAQTFWPRRDLGIEAWWAPKTLPVEAWVRVGNGSRSPLGNDNSLPALDARVDGRWGRARGDVDAFWGFRAGAGVHVENAYDRAGIGGIGPQNFVFYRAPPVSGPRSVVEAHARLDVGPVRVLAEGAAAWERRSRDTDGNPNTPREGLPRMESQGASLEVSWVVVGRPRGDGARWPVAPNDPTGMDAVNAGQVPTGAVELAARVERLWLGRGASDIQPGGTTGGALAVRWWVTSFFGLGAAGYAQRYDTAPLEDPGRRNSWLALARATVSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I8</accession>
    <name>Q1D8I8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="12" type="ORF">MXAN_2818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552885.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2818"/>
    <dbReference type="EnsemblBacteria" id="ABF90319">
        <property type="protein sequence ID" value="ABF90319"/>
        <property type="gene ID" value="MXAN_2818"/>
    </dbReference>
    <dbReference type="GeneID" id="41360194"/>
    <dbReference type="KEGG" id="mxa:MXAN_2818"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_2_1_7"/>
    <dbReference type="OMA" id="VIHLMIV"/>
    <dbReference type="OrthoDB" id="2072369at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="12872" checksum="295E8449B9100D4F" modified="2006-07-11" version="1">MLTFVTIVHVLVCVFMIFVILLQPGKDAGMGSALGGGAATSAFGGRGAVTFLSKLTGVFAALFFFSSLGLSFVGLRSSVAAGGSVASPPAQSAPATSGDAAPGSMEQPRGEQSTPPAEGGGNPATGEPAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B0</accession>
    <name>Q1D9B0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552614.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2544"/>
    <dbReference type="EnsemblBacteria" id="ABF93105">
        <property type="protein sequence ID" value="ABF93105"/>
        <property type="gene ID" value="MXAN_2544"/>
    </dbReference>
    <dbReference type="GeneID" id="41359922"/>
    <dbReference type="KEGG" id="mxa:MXAN_2544"/>
    <dbReference type="eggNOG" id="COG4850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066171_0_0_7"/>
    <dbReference type="OMA" id="WDLDKTY"/>
    <dbReference type="OrthoDB" id="506489at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="346" mass="38500" checksum="FF224F6C7C6D15E7" modified="2006-07-11" version="1">MSLPDRIDPRPPRRIYRWDLDKTYLQTEFDSLRDLVRTAFQKAHQKVAVPGASALIRELSENGDSRLCIVSGSPKQMRAVLEEKLKLDGVRWDEFVLKDNVGNLLRGRFRALRGQVGYKLPAILESRVHAPVEAEEVLFGDDAEADAFIYSLFADLVAGRVDERVLSQVLEAGGVYPDDALRVREAWKKIPVGDPVRRIFIHLDRLTPPAHFTPYGPRVVPIFNYFQAALVLLADGHLTAPQVLKIAVEMVQTAGHNIITLSNSFQDLLRRGLPLQQAAVALSQALEGPNKLLAAMRPMPDILAAFSKRLAALGTPPPPPPVQAVDYVSLIHHALPRNHKGRTKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E8</accession>
    <name>Q1D9E8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system protein J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP J family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2506"/>
    <dbReference type="EnsemblBacteria" id="ABF86453">
        <property type="protein sequence ID" value="ABF86453"/>
        <property type="gene ID" value="MXAN_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2506"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107549_0_0_7"/>
    <dbReference type="OMA" id="KEWDDEW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010055">
        <property type="entry name" value="T2SS_protein-GspJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11612">
        <property type="entry name" value="T2SSJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="26125" checksum="153B723D3A7D11AC" modified="2006-07-11" version="1">MMRRHTRGFTLMEVMVAVAITALMGTVVAMAFQTGLTAKETVEVDADRYRQVRVAMNRMAREIGSAYVSDRYDSTRFRDQNDRPSNFVGERGKLLFTTFSHQRLYTDVKESDQAIVGYFVEASEDREARGRQDLKRRVNANIDERMEQGGHVDVLFEGVKELEFAYWDSEKKEWDDEWDTRRTERKSILPTRVRVTLTAVDETGKEARYVTQARIMLNTELPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9R7</accession>
    <name>Q1D9R7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552461.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2386"/>
    <dbReference type="EnsemblBacteria" id="ABF86938">
        <property type="protein sequence ID" value="ABF86938"/>
        <property type="gene ID" value="MXAN_2386"/>
    </dbReference>
    <dbReference type="GeneID" id="41359771"/>
    <dbReference type="KEGG" id="mxa:MXAN_2386"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024627_0_0_7"/>
    <dbReference type="OMA" id="HVESTTF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="258"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="395"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="644"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="763" mass="83368" checksum="6E6D6F6FC0A76C57" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA18</accession>
    <name>Q1DA18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552360.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2284"/>
    <dbReference type="EnsemblBacteria" id="ABF86785">
        <property type="protein sequence ID" value="ABF86785"/>
        <property type="gene ID" value="MXAN_2284"/>
    </dbReference>
    <dbReference type="GeneID" id="41359671"/>
    <dbReference type="KEGG" id="mxa:MXAN_2284"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077387_0_0_7"/>
    <dbReference type="OMA" id="LHMKRAE"/>
    <dbReference type="OrthoDB" id="1368757at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26171" checksum="94A5E84A0EBA0F6C" modified="2006-07-11" version="1">MERNGREACPPELAAQLREVDRLRRSGRYASALTLARALAEAHPRQARVLLEVAQTLAIWGGVPGEALEWYERVLALAPGHLTSRLHRALCLSRLSRHEEAVADFDALVASGYRKALVLHMKRAEALEALGRDEAAERDWTLAIEEALGNPWLLQQRAAARARLGRLDDAAQDLTEALASQTGDEVDPELLHARGVLRERQGDVDGARADFEAGLSAFREGDPPALLDALREGTMRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAV0</accession>
    <name>Q1DAV0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PUA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1988"/>
    <dbReference type="EnsemblBacteria" id="ABF91741">
        <property type="protein sequence ID" value="ABF91741"/>
        <property type="gene ID" value="MXAN_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1988"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_7"/>
    <dbReference type="OMA" id="YHELNLR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA_3" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="398" mass="43445" checksum="ECEA8A351AD52761" modified="2006-07-11" version="1">MSLMPPHAALPVARVTPKGARSLRHFNPWVYRTEIAAPPDVKGAGAVVLVVDSQGNPIGQALYARRSPLALRLLTRKGPAEEPVDDAFFRRRLEAALARRAYLSGRDGLRLVHGEADQLPGLFVDRYGKGLTLQTLSEGMDARKETLAKMLVELTGATHVMCRDDASGRDFEGLPREARLLHGEGAARFTYHEGENRFEVDLQGDMKTGAFLDQVDNHLRAGELARGDALDLFSYHGGFALSLSRTCTSVLAVEQDEKAAARAKANAEANGRANVTVENANAFDVLRRFDTSGRRFDTVVLDPPGLAKRREGLATALRAYHELNLRAFRCLKPDGLLVTCSCSGKLDRAAFEEMVLAAAADAKRPVQILERRGAGLDHPVLAGLPETEYLKALYVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB09</accession>
    <name>Q1DB09_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552020.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1920"/>
    <dbReference type="EnsemblBacteria" id="ABF86047">
        <property type="protein sequence ID" value="ABF86047"/>
        <property type="gene ID" value="MXAN_1920"/>
    </dbReference>
    <dbReference type="GeneID" id="41359334"/>
    <dbReference type="KEGG" id="mxa:MXAN_1920"/>
    <dbReference type="HOGENOM" id="CLU_2437733_0_0_7"/>
    <dbReference type="OMA" id="RIQKPQA"/>
    <dbReference type="OrthoDB" id="2018662at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188589" evidence="1">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="9891" checksum="E5A77068054973B0" modified="2006-07-11" version="1">MRSAFALIVLLAAAPVLAQDASQASSSSSGATSPKKAPRKVIRLEAITVEGRIQKPQAMYILQRSNLSFDDLSRTESFVPKVEKSVEQEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB26</accession>
    <name>Q1DB26_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89210">
        <property type="protein sequence ID" value="ABF89210"/>
        <property type="gene ID" value="MXAN_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1902"/>
    <dbReference type="HOGENOM" id="CLU_2917803_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="61" mass="6495" checksum="F37D4E81F1BC5607" modified="2006-07-11" version="1">MKDVADALCCHSPEDGPAFLGPKKSRSGVTSCQVASGTSSRTMFLRLEMALAAEQPGLHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF5</accession>
    <name>Q1DBF5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LZ_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1768"/>
    <dbReference type="EnsemblBacteria" id="ABF88507">
        <property type="protein sequence ID" value="ABF88507"/>
        <property type="gene ID" value="MXAN_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1768"/>
    <dbReference type="HOGENOM" id="CLU_1584722_0_0_7"/>
    <dbReference type="OMA" id="GWEESCQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="3">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="18211" checksum="8F2DD6B09F38BD2B" modified="2006-07-11" version="1">MNRASAQVREARTAEATSSLTQGAPSRKPQTSSPRGAELKRAAVAALTVERDTLRLAYRNLQQELELMRSRLFVAKAERLDTTQLGLEFAYKLAALDALNHQLGQPAASAPADPTETGGARPPGGKRKPTGRRDLREADLPEERIELNAPLLEGSAPRSGWEESCQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG6</accession>
    <name>Q1DBG6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551866.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1757"/>
    <dbReference type="EnsemblBacteria" id="ABF91652">
        <property type="protein sequence ID" value="ABF91652"/>
        <property type="gene ID" value="MXAN_1757"/>
    </dbReference>
    <dbReference type="GeneID" id="41359186"/>
    <dbReference type="KEGG" id="mxa:MXAN_1757"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_16_1_7"/>
    <dbReference type="OMA" id="SWWEVGD"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="34922" checksum="9A78AA61AA513FFB" modified="2006-07-11" version="1">MQVLIVNTSLFPHLQTFLAVARTRSFSAAARDLGISRSAVSQSVRLLEGKLRVPLVARTTRSVSLTEAGRRLVESAGPAVTQVQAALTQASAKPGEVVGRVRLTVPRAAFHFVIEPVLPKFRERHPRIEVDLVFEDRMVDLVGEGFDAGVRLSEYVERDMVSVRLTDAFRFIVVGSPTYLGRHGTPGRPEDLLEHECLTFRSSTTGSLYAWEFERGRRTWRVPVRGSLVVNDGLICIRWAEQGLGLAYVMEPLVGEQLRKGSLQRVLEPYAATVPGFFLYYPSRAQSSAPLRLFVETVRELTRKPPVATKQLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI1</accession>
    <name>Q1DBI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551851.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1742"/>
    <dbReference type="EnsemblBacteria" id="ABF90268">
        <property type="protein sequence ID" value="ABF90268"/>
        <property type="gene ID" value="MXAN_1742"/>
    </dbReference>
    <dbReference type="GeneID" id="41359174"/>
    <dbReference type="KEGG" id="mxa:MXAN_1742"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026026_0_0_7"/>
    <dbReference type="OMA" id="WATYFHH"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="281" mass="32552" checksum="CAD32E786D285206" modified="2006-07-11" version="1">MTLFRHPRDRIPVLLFTLVFALDLTVFFTARSWWFPILWLALGVIPKGWISAWNHHHQHVPMFRHALPNRLLEVIFGFQTGVTSHAWFLHHVLGHHRNYLDQTQDESGWKRRDGSTMGEAEYSVFNTLVAYPRAFRVGRSYPKVMRVFLAMGALQVALLGVLFWHDWYNALWVFLLPMAVSLYVTVWATYFHHVGLEATEHTHASYNILHKGYNLMTGNLGYHTAHHAKHGLHWSQLPELHAQLAQDIPATHYRQPGIPFVWTNPEAKIEPAEAEFGAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ7</accession>
    <name>Q1DBQ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance transporter, EmrB/QacA subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DK1622</strain>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC04</accession>
    <name>Q1DC04_MYXXD</name>
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            <fullName evidence="5">Urea amidolyase-like protein</fullName>
        </submittedName>
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    </gene>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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                <person name="Sullivan S.A."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="30571" checksum="D16B1E5A5C677266" modified="2006-07-11" version="1">MTGWLDITGVGAPVTVQDAGRPGKMHHGVPPGGPLVPELLALANLAVGNASGTAALEAFGRLELRARGRSVRVSMGGHAFALADGERLTVPAPESTSVRYVAVDGGLAVPEVLGGRGTLLVARLGGHEGRLLRSGDSLPLGDTNERAEARAPGASLDAAAPIRVTLGPDNRRFGPATVATLLSGAFTVSAATDRVGMRLQGPSLTHGDEGTGTSRPMVRGAIQVTLSGTPIVLGPDHPTTGGYPLIATVIRADWGRLCARRPGAAVRFQEVSLEEAREAWRHHAEHFGVGGRPTPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC28</accession>
    <name>Q1DC28_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551654.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1543"/>
    <dbReference type="EnsemblBacteria" id="ABF89447">
        <property type="protein sequence ID" value="ABF89447"/>
        <property type="gene ID" value="MXAN_1543"/>
    </dbReference>
    <dbReference type="GeneID" id="41364686"/>
    <dbReference type="KEGG" id="mxa:MXAN_1543"/>
    <dbReference type="HOGENOM" id="CLU_077132_0_0_7"/>
    <dbReference type="OMA" id="MKFYVVE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="26948" checksum="956FBFA762A585B7" modified="2006-07-11" version="1">MKFYVVEEDRAAGFTGNLRAVPPWGLPGVSPCDTCGAAGGWAGLQYPCVDLSGLQERKALENPGRQVGFEEFSRLRDLVRPFAPDWARLEPGADFGPPTGTGSGTFGDLFLQNPWSLYIRREAVERLQGAGIHGLSGCPLNVRFRGKNPPELLAMQLELHGRLHLDGVSPGEGPVCLTCGVSRHELPRPPILDVHSTPAPRDLFRLYNWPTLIVASERMVAAVQHLSLRGIRFSEFATRQGPSVSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB6</accession>
    <name>Q1DCB6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551566.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1450"/>
    <dbReference type="EnsemblBacteria" id="ABF92713">
        <property type="protein sequence ID" value="ABF92713"/>
        <property type="gene ID" value="MXAN_1450"/>
    </dbReference>
    <dbReference type="GeneID" id="41358896"/>
    <dbReference type="KEGG" id="mxa:MXAN_1450"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006298_3_0_7"/>
    <dbReference type="OMA" id="INQDHNV"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="614"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1132" mass="122449" checksum="02AFCFF608CEDF82" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM5</accession>
    <name>Q1DCM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551458.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1341"/>
    <dbReference type="EnsemblBacteria" id="ABF89806">
        <property type="protein sequence ID" value="ABF89806"/>
        <property type="gene ID" value="MXAN_1341"/>
    </dbReference>
    <dbReference type="GeneID" id="41358787"/>
    <dbReference type="KEGG" id="mxa:MXAN_1341"/>
    <dbReference type="eggNOG" id="ENOG502Z7SX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065508_0_0_7"/>
    <dbReference type="OMA" id="KCLRECG"/>
    <dbReference type="OrthoDB" id="1574258at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027056">
        <property type="entry name" value="Gluconate_2DH_su3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13618">
        <property type="entry name" value="Gluconate_2-dh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="23739" checksum="F1D38CFE837C2E76" modified="2006-07-11" version="1">MTRAHSNRGRLSRRSLIQRLTFLGGGVVLLGPACKRSSESQEKTPPADTGPLAAKQDGQAPRTFSSFEYAVVAAATERILPRDEDPGALDANVPVYIDRILQTPELEPVREDFLSGVAALERRAQRMHQKGFAALTAEQQDELLTLFKDSPPRSGEAHFFELLTVMTLEGFLGDPSYGGNQGKVGWRLMGFDTVGTVASAPPEGYDGPKCLRECGVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCU7</accession>
    <name>Q1DCU7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551386.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1269"/>
    <dbReference type="EnsemblBacteria" id="ABF86465">
        <property type="protein sequence ID" value="ABF86465"/>
        <property type="gene ID" value="MXAN_1269"/>
    </dbReference>
    <dbReference type="GeneID" id="41358715"/>
    <dbReference type="KEGG" id="mxa:MXAN_1269"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446061_0_0_7"/>
    <dbReference type="OMA" id="ESDLYCV"/>
    <dbReference type="OrthoDB" id="132527at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="197"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="201"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="393"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="612" mass="65695" checksum="5DA2A9CD3C634979" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD96</accession>
    <name>Q1DD96_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91301">
        <property type="protein sequence ID" value="ABF91301"/>
        <property type="gene ID" value="MXAN_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1117"/>
    <dbReference type="HOGENOM" id="CLU_119555_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="149" mass="16176" checksum="F5449A169E8F2EFF" modified="2006-07-11" version="1">MCKLLFMENEPSLHCCAMWGPLAAIVLSALGCGGSAHSTAARQPVYLAQAQCGPMDSTVSCCVKMHPATPERCGLTASEASKYLVPMKAVESASEASEEAIPGWKQVCIDAYAQCQEQAWSGSCYDCFRYCEGQHEWPVDKCRRRKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDF4</accession>
    <name>Q1DDF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551179.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1058"/>
    <dbReference type="EnsemblBacteria" id="ABF86759">
        <property type="protein sequence ID" value="ABF86759"/>
        <property type="gene ID" value="MXAN_1058"/>
    </dbReference>
    <dbReference type="GeneID" id="41358511"/>
    <dbReference type="KEGG" id="mxa:MXAN_1058"/>
    <dbReference type="HOGENOM" id="CLU_1452988_0_0_7"/>
    <dbReference type="OMA" id="RLWMRTA"/>
    <dbReference type="OrthoDB" id="1516122at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19115" checksum="B2BB69B84C0C2091" modified="2006-07-11" version="1">MSRLLAASLLILVFAPGCKPGSGEGASGGQPPPEVVLHGARLESFEGDRLIRSGTARQVSYQRTTGEVWATDATIRIPPGSSSQGAPPGTEGGVEVSAPNMEGSLASKQVVASGGVIIRTGKGMEARTPRLTYDATTERAHGNEGVTVKGPDYRLRADRFELFFPDETFNFAGSVESVLGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH6</accession>
    <name>Q1DDH6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, group 2 family protein</fullName>
            <ecNumber evidence="1">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551157.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1036"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87694">
        <property type="protein sequence ID" value="ABF87694"/>
        <property type="gene ID" value="MXAN_1036"/>
    </dbReference>
    <dbReference type="GeneID" id="41358490"/>
    <dbReference type="KEGG" id="mxa:MXAN_1036"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_0_1_7"/>
    <dbReference type="OMA" id="DACAPFL"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="35835" checksum="DFEE84050E39CC4B" modified="2006-07-11" version="1">MKKPDLVISIVNHSNPELLHDCLRTLYATTRDSSFEVWIVDNATGGRGVDAMRRDFPQVRWLFNTERKGFSANHNQVLRQARGRHFCIFNDDTIVHEGAFDALVRFMDDNPRVGMAGARLLNADGTIQNCTFRPMSLAGQLFDIVFLPRPLHFLKAMAIDPAQYGHDEARVSWVLGACIVVREEALAEVGLLDEQMSPLGNTEDTDWCVRAWKAGWEVAFCPEAVITHLTSRSFRPSDTGADKVRIELWRTRLAYFRKHHGRLHETAMRAILVGTLPYNSAVLTQTLLRGRMSLPEYRKQLATFLGISQMGLRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDK8</accession>
    <name>Q1DDK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551125.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1004"/>
    <dbReference type="EnsemblBacteria" id="ABF88227">
        <property type="protein sequence ID" value="ABF88227"/>
        <property type="gene ID" value="MXAN_1004"/>
    </dbReference>
    <dbReference type="GeneID" id="41358459"/>
    <dbReference type="KEGG" id="mxa:MXAN_1004"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527759_0_0_7"/>
    <dbReference type="OMA" id="DQRMPAD"/>
    <dbReference type="OrthoDB" id="296522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188175" evidence="1">
        <location>
            <begin position="23"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="509" mass="53679" checksum="5429460E61B67C0E" modified="2006-07-11" version="1">MRIHPRASASAVLSLLSLVVLGACGEDRSLPLDKPEPTPFQPVQVPAVTALAPVSGFADQAGGGVFATASRELVRLRLDGTYGALEPHPDNEAAAGGILGVFRLGPHSALVETQTGLFMAESGWLIAPPWRDALGQGVIATAQSADGAVWLAHTRGLFRLQEGTLAELKVDGASVKAITSLAAAPSPENLPGVWFLHEGGLSVAVALSTAHYRVHTTSAPLAEGESLQALAGIGPAVGTSGELWALTNQALLRRGKDGWRRVELPQQPQKLIGSGRFLWAKTGGSLLQYDADANVWRAATDAGAGDFHFLAADESGSVWVQQGGVSVALSHVLVPRLRGLYQGMQLVNDGLVVRAVMPPGGAPESVVYKLGNSEIPTEGPDYSLGGLEADGTHRAYSFASLEAGRYVLSVVARYADGSEAQRSVPFDYAPLASGPLSWDKDIRPIHEARCRNCHNSSSAARSLDSYELWRANAPIITGAVRDQRMPADGPMDPELISRIQRWASSGARP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP4</accession>
    <name>METN_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine import ATP-binding protein MetN</fullName>
            <ecNumber evidence="1">7.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metN</name>
        <name type="ordered locus">MXAN_0968</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:29767"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57932"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.4.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551089.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDP4"/>
    <dbReference type="SMR" id="Q1DDP4"/>
    <dbReference type="STRING" id="246197.MXAN_0968"/>
    <dbReference type="EnsemblBacteria" id="ABF92093">
        <property type="protein sequence ID" value="ABF92093"/>
        <property type="gene ID" value="MXAN_0968"/>
    </dbReference>
    <dbReference type="GeneID" id="41358426"/>
    <dbReference type="KEGG" id="mxa:MXAN_0968"/>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_3_7"/>
    <dbReference type="OMA" id="VFITHEI"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51264">
        <property type="entry name" value="METN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000270334" description="Methionine import ATP-binding protein MetN">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01719"/>
        </source>
    </evidence>
    <sequence length="330" mass="35185" checksum="1BD5792676B7144D" modified="2006-07-11" version="1">MIAFRGVSKVYTAGGREVAALRNVSLRVEAGEIHGVLGQSGAGKSTLIRCANLLERPTEGSVSVDGQDLLALSPEALRKARQGIGMIFQHFNLFGSKTVAANVAYPLEVAGTPREAIRERVEELLSLVGLSDKAQAYPSQLSGGQKQRVGIARALAPRPRVLLSDEATSALDPETTRSVLGLLRDINQKLGVTLLLITHQMDVVKAICDSVSVLERGRLVEQGKVTELLAHPSTRLHQLCFPAFAAPTDAPSGRRVALTLAGEHARRPLLGTLARQFDVDALLVEGAMERVGNTRVGRLLVDLQGSADAVSQALAYLREQGLTLEEAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP8</accession>
    <name>Q1DDP8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M14 family</fullName>
            <ecNumber evidence="2">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.17.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551085.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0964"/>
    <dbReference type="EnsemblBacteria" id="ABF92192">
        <property type="protein sequence ID" value="ABF92192"/>
        <property type="gene ID" value="MXAN_0964"/>
    </dbReference>
    <dbReference type="GeneID" id="41358422"/>
    <dbReference type="KEGG" id="mxa:MXAN_0964"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032905_0_0_7"/>
    <dbReference type="OMA" id="SNGADYQ"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="32"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="591" mass="65421" checksum="EC64E12D12165D16" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDR0</accession>
    <name>Q1DDR0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ORF">MXAN_0952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551073.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0952"/>
    <dbReference type="EnsemblBacteria" id="ABF92855">
        <property type="protein sequence ID" value="ABF92855"/>
        <property type="gene ID" value="MXAN_0952"/>
    </dbReference>
    <dbReference type="GeneID" id="41358411"/>
    <dbReference type="KEGG" id="mxa:MXAN_0952"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_2_0_7"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="24323" checksum="531C042BEAD1CD1F" modified="2006-07-11" version="1">MSATRTHVVPTESLPREAATWMARALQDTLATQRRVSLALSGGSTPGPAYRALAAQVLPWERVDVYFVDERFVPPDHADSNYRMVEDTLLRPLRLSPSQVFRMEGEREDRDAAAKDYAAKLPASLDVVLLGMGEDGHTASLFPGHPALEESEQRVLAVVGPKPPPWRMTLTLPVLRSARHVLTLVSGAGKQDTVRRALAGDLSLPAARVTNSEWMLDPAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE48</accession>
    <name>Q1DE48_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MG2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550935.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0812"/>
    <dbReference type="EnsemblBacteria" id="ABF88700">
        <property type="protein sequence ID" value="ABF88700"/>
        <property type="gene ID" value="MXAN_0812"/>
    </dbReference>
    <dbReference type="GeneID" id="41358278"/>
    <dbReference type="KEGG" id="mxa:MXAN_0812"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293699_0_0_7"/>
    <dbReference type="OMA" id="DVENWNA"/>
    <dbReference type="OrthoDB" id="53177at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MG2" evidence="1">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110429" checksum="D57561185E7BCCD9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE6</accession>
    <name>Q1DEE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550837.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0709"/>
    <dbReference type="EnsemblBacteria" id="ABF88021">
        <property type="protein sequence ID" value="ABF88021"/>
        <property type="gene ID" value="MXAN_0709"/>
    </dbReference>
    <dbReference type="GeneID" id="41358182"/>
    <dbReference type="KEGG" id="mxa:MXAN_0709"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_4_2_7"/>
    <dbReference type="OMA" id="HDMAIRE"/>
    <dbReference type="OrthoDB" id="271085at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="246"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="491" mass="53465" checksum="115BB3BA1E277B4C" modified="2006-07-11" version="1">MSSSEQPARQDARVSTGVPGLDAVLGGGLVSSGVYIFVGEPGAGKTLFANQLCYHQGRAGARCLYVTLLAESHARMLANMRDMAFFDSALLPEGVYYVSGFRTLEEHGLPGLLELLRREVRNHNASILVLDGLVQAQEAAGSSRDFKKFIHELQVAAGLTRFTALLLTSANGPAVHPEYTMVDGILELRERTQGVRSWRELQVRKFRGSPTLHGVHAFRITSDGLEVFPRLESRVQRTPPPDPGAHRLHFGVPSLDALFPEGLAAGSTSLLLGPPGAGKTLLGCSLLAEGLKQGEHCLYMGFYEPPNRLLGKVASAGIDLGGAMADGRLNFIWQPPSECILDVLADQLLSDVRRRNVKRVFVDGLSAMQQASPEPARINSFFAALTQELRCTGTTTLFGMETPRLFGPVLDVPMEVGPSAVAENLFFLRHVELEGRLRRLLSIFKMRDTHYDPTLREFVITPQGIEVLPPFSVAVDTLLTGLARHPGTGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DES3</accession>
    <name>Q1DES3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2135 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0582"/>
    <dbReference type="EnsemblBacteria" id="ABF90651">
        <property type="protein sequence ID" value="ABF90651"/>
        <property type="gene ID" value="MXAN_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0582"/>
    <dbReference type="eggNOG" id="COG4676">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936353_0_0_7"/>
    <dbReference type="OMA" id="DRYLMRT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019220">
        <property type="entry name" value="DUF2135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09906">
        <property type="entry name" value="DUF2135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2135" evidence="1">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="32294" checksum="63F2733E4EDE6243" modified="2006-07-11" version="1">MMLPVLLAVLLAQTPASNPRQQGVPIGKGKTLPVVTLSAPSGGWTVDRMMLIEGTVSDTTIDPVVVSINGDRYLMRTYRGRFSRKFPAASGKNVVTVMATNQAGTARTQATSYAQIPPVPFKVVLTSDTDGVYTDLHLYEPTDASAKDGTLDVRKMAHVYWADTASPSGGTFFLNSQGGDFDQPAYGPYLYIHRSPPKGVYLVATNYWPSGDKAHTVATLNLSLFEGTPNEIRRMVRIPLATPGTTRVLAWVNVLGDGQAEVFVPSQDPRPKHAAWPKNLDEALKALQSNEDGGGEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEV4</accession>
    <name>Q1DEV4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550682.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0550"/>
    <dbReference type="EnsemblBacteria" id="ABF89356">
        <property type="protein sequence ID" value="ABF89356"/>
        <property type="gene ID" value="MXAN_0550"/>
    </dbReference>
    <dbReference type="GeneID" id="41358034"/>
    <dbReference type="KEGG" id="mxa:MXAN_0550"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852126_0_0_7"/>
    <dbReference type="OMA" id="GLQEWSL"/>
    <dbReference type="OrthoDB" id="1068097at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188565" evidence="1">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="324" mass="35311" checksum="79E33336D02D61AF" modified="2006-07-11" version="1">MKRLCLLLTLPLFPLLSTDAHAASTDTHPALRASTCSVRGLMDDIRRGLGSGSPSYQRYLRTLLREAAVTLPDAELRDAFARETDPVMAEHLAAALVARAEREADTQAMDVVAQRALHDADPSVRAATLRAMRRTSALERTGDLYERMVRDESPQVRQEAATNLIEDNAHVYAGQYGPAADTAVTAAVASTDPAVTARILDNLSTEKISAESADRITSLLRSDDASVRKAAVNALGGVPAEQMQGARESLLAMYREETDEGVRKALLQSVAQLGFEGAIPDLQRMRAMDPRLAQEADAWIQVLGMGLQEWSLLLREKQRLQQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF76</accession>
    <name>Q1DF76_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0427"/>
    <dbReference type="EnsemblBacteria" id="ABF87552">
        <property type="protein sequence ID" value="ABF87552"/>
        <property type="gene ID" value="MXAN_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0427"/>
    <dbReference type="HOGENOM" id="CLU_2700911_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="8215" checksum="DB74F6AF74CB8888" modified="2006-07-11" version="1">MLRNPPRSGLLFLPVVIGWGEDPTGREALQAQGKSNLVVIREDLANDILRAGCDGMIFQEMDDYGREWGKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFA6</accession>
    <name>Q1DFA6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0396"/>
    <dbReference type="EnsemblBacteria" id="ABF89396">
        <property type="protein sequence ID" value="ABF89396"/>
        <property type="gene ID" value="MXAN_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0396"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017697_0_0_7"/>
    <dbReference type="OMA" id="NTSMRIN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="642" mass="68404" checksum="6D14EAE6E5D11960" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFI6</accession>
    <name>Q1DFI6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550451.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0307"/>
    <dbReference type="EnsemblBacteria" id="ABF88751">
        <property type="protein sequence ID" value="ABF88751"/>
        <property type="gene ID" value="MXAN_0307"/>
    </dbReference>
    <dbReference type="GeneID" id="41357806"/>
    <dbReference type="KEGG" id="mxa:MXAN_0307"/>
    <dbReference type="eggNOG" id="COG2425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030793_0_0_7"/>
    <dbReference type="OMA" id="AWEYGDD"/>
    <dbReference type="OrthoDB" id="223121at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="7">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="555" mass="62144" checksum="97D8B70E1AB60E3D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ9</accession>
    <name>Q1DFJ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550438.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0294"/>
    <dbReference type="EnsemblBacteria" id="ABF89097">
        <property type="protein sequence ID" value="ABF89097"/>
        <property type="gene ID" value="MXAN_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="41357793"/>
    <dbReference type="KEGG" id="mxa:MXAN_0294"/>
    <dbReference type="HOGENOM" id="CLU_163319_0_0_7"/>
    <dbReference type="OMA" id="HRFYRET"/>
    <dbReference type="OrthoDB" id="1742718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="14259" checksum="17995F5E955641C7" modified="2006-07-11" version="1">MTWAVIRYHPPGPFQLVGRKARHRTMDAWTLEGSRITDPDTLSRLREMLANKSPLIIEHRFYRETRAPHRFICDDADVLDEYLQESRPGDSFCVWSYKSLCRGDNLLLQGKMPDAQGRTPGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFQ0</accession>
    <name>Q1DFQ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550387.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0242"/>
    <dbReference type="EnsemblBacteria" id="ABF93118">
        <property type="protein sequence ID" value="ABF93118"/>
        <property type="gene ID" value="MXAN_0242"/>
    </dbReference>
    <dbReference type="GeneID" id="41357742"/>
    <dbReference type="KEGG" id="mxa:MXAN_0242"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OrthoDB" id="1412466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="24356" checksum="9CAF2610F3A48930" modified="2006-07-11" version="1">MRIHPGLGLSLLVAFWLGCSTTAKTPIQRGARAATEACSGSHEDRCVSLLCEGDACGFYRCEDLLGEVELARFPPARPPVAAAAPGSGPRRNWGGGQQLPRGAVMVFPNWNGGSSRVIPPSHRLTPGRWEKHHIFPQAEDLARWFEGQGVKIHSYTMPIPRDVHRRIHGPLGNGGAWNKAWREFRNRNASAEEIFKHAGELIHRFELIGGPIQPYYSRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR1</accession>
    <name>Q1DFR1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550376.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0230"/>
    <dbReference type="EnsemblBacteria" id="ABF89054">
        <property type="protein sequence ID" value="ABF89054"/>
        <property type="gene ID" value="MXAN_0230"/>
    </dbReference>
    <dbReference type="GeneID" id="41357730"/>
    <dbReference type="KEGG" id="mxa:MXAN_0230"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_76_7"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="258"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="378"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="121"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="57231" checksum="5EAD491EE8C2BBDC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX1</accession>
    <name>Q1DFX1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0169"/>
    <dbReference type="EnsemblBacteria" id="ABF91488">
        <property type="protein sequence ID" value="ABF91488"/>
        <property type="gene ID" value="MXAN_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0169"/>
    <dbReference type="HOGENOM" id="CLU_2143158_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="112" mass="12813" checksum="C7B92A96442D6A03" modified="2006-07-11" version="1">MAVVRGVRGEWRALSKEPFKRFEALRFARRLLDEGSLVLKQHAKDRMKERNLATTDIENIIEGGVVNSEGEQKDGRWTYVIETPRMGLAVAFRCDEAGEAHELVIVSVWRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG36</accession>
    <name>Q1DG36_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550251.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0104"/>
    <dbReference type="EnsemblBacteria" id="ABF88549">
        <property type="protein sequence ID" value="ABF88549"/>
        <property type="gene ID" value="MXAN_0104"/>
    </dbReference>
    <dbReference type="GeneID" id="41357609"/>
    <dbReference type="KEGG" id="mxa:MXAN_0104"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074977_0_1_7"/>
    <dbReference type="OMA" id="WFAACRA"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="33226" checksum="0F14F3140F1F6A63" modified="2006-07-11" version="1">MAHDAEQSPALTDAEAAERIHARFPALATARVVRLGEGTDHQAFEVEGRYVFRFPKSDEAAEHLKWEARLLAWLGPRLPLPVPDYRFLAHPAADLAAGFAGYEKLPGTPALLVEPERLDLSDLGRRLGAFLRALHALDPAEAAALGVPADDDPELEAWSAAAVDDLRLAVEHSHMEPHRAADWEQRLRVRPTEGRGAPRLVHGDFAAEHVLVDSHGAPTGVIDWSDACVGDPARDFAGLLHWGGAPMLTASLETYGAVSPAVLTRARWFAACRAVADIAFGQTQGRPEYIAAGQRALTGLGKHPPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG67</accession>
    <name>Q1DG67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550220.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0073"/>
    <dbReference type="EnsemblBacteria" id="ABF87294">
        <property type="protein sequence ID" value="ABF87294"/>
        <property type="gene ID" value="MXAN_0073"/>
    </dbReference>
    <dbReference type="GeneID" id="41357580"/>
    <dbReference type="KEGG" id="mxa:MXAN_0073"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_7_0_7"/>
    <dbReference type="OMA" id="FEVCPTL"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="61"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="16401" checksum="A97FD72FE6F05782" modified="2006-07-11" version="1">MSDDFTLPEDKAERMERCAIFYTDVVPHNHALGLRLVDIRAAEATVELPYAENLVGNPETGVIAGGAVTTLIDATCGTAVFLRLGRFAPLVTLDLRIDYLRPARPGIVLTCVAECYRLTRQVAFVRAFVHQGDPGHPVASAQGTFMRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH9</accession>
    <name>Q1CVH9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7491"/>
    <dbReference type="EnsemblBacteria" id="ABF88629">
        <property type="protein sequence ID" value="ABF88629"/>
        <property type="gene ID" value="MXAN_7491"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7491"/>
    <dbReference type="eggNOG" id="ENOG5030DVV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101914_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="27772" checksum="D583064128FC70DA" modified="2006-07-11" version="1">MSIGAAGACSQRCKRIIRAFRVAASVAVSRQIPPRAAPVRAGAVQSPARGRVRQRAVTGLPRSGVAVGLGSRLGHRASSQGPLYALATRAPRALPVRSNSMTRKDILEAVKSFVGVLDEQNHFEDREGVLRASLDRLALAYHFADAPFDPTKYPDAPRADYRSLRECIAPLFPALGLYNEALHIADKVGESEFSIGDAIDDLTDIAMDMHSVLFRWENTSEGDALWHFRFGFETHWGLHLRSLQLYLHQRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW3</accession>
    <name>Q1CVW3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557265.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7352"/>
    <dbReference type="EnsemblBacteria" id="ABF88034">
        <property type="protein sequence ID" value="ABF88034"/>
        <property type="gene ID" value="MXAN_7352"/>
    </dbReference>
    <dbReference type="GeneID" id="41364513"/>
    <dbReference type="KEGG" id="mxa:MXAN_7352"/>
    <dbReference type="eggNOG" id="ENOG5032P0Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112879_0_0_7"/>
    <dbReference type="OMA" id="HRAGGMV"/>
    <dbReference type="OrthoDB" id="1255131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="198" mass="21328" checksum="C460D4EAE985E713" modified="2006-07-11" version="1">MNKMDPNIAKELDARLALATKDDTARGLFFNGVVSAVRTMGGDAAVERCLAASGETRFIDFFNYPVAAFLRMSFTAAQVMGPEHGGFDGALRRMGVVATTDFLSSAAGKTLLLLASDSPKRLVGNLHSGYRAAVSYGERAVKWTGDTSGIFTMKRDFMPPAYHEGTLQAVIEAVGGKQVQVHGRQTGPLDTEYTLSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW01</accession>
    <name>Q1CW01_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557228.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7309"/>
    <dbReference type="EnsemblBacteria" id="ABF89911">
        <property type="protein sequence ID" value="ABF89911"/>
        <property type="gene ID" value="MXAN_7309"/>
    </dbReference>
    <dbReference type="GeneID" id="41364472"/>
    <dbReference type="KEGG" id="mxa:MXAN_7309"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272224_0_0_7"/>
    <dbReference type="OMA" id="REPTWAV"/>
    <dbReference type="OrthoDB" id="1913352at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134985" checksum="F63D1A51CE534EC6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB9</accession>
    <name>Q1CWB9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7191"/>
    <dbReference type="EnsemblBacteria" id="ABF93155">
        <property type="protein sequence ID" value="ABF93155"/>
        <property type="gene ID" value="MXAN_7191"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7191"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064723_0_0_7"/>
    <dbReference type="OMA" id="WTEDRYF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="32932" checksum="09374BBEAF5835BF" modified="2006-07-11" version="1">MRPRFVRGRCPWGVHWLKRAAVSPPVSPHVPFQGHGRAMSALPFDVAAASVLGREHARAGRNNQDALCIRASEHGLVAVVTDGCGSQPCSELGAQLGARRLARAALVRLADGERVDEPTFLPGLREDVLCLLSELRADLGREVMGDFLFTVVGAVVTPSLTLVFSAGDGVWALNGEVHPLGPFPGNAPPYLAYALMHGEDVALTTRALVPTEDVHALLLGTDGVVDLERLATTRMPAGNELVGPLSRLWTEDRYFANPDALRRRLALLNREAVRADFASQQLARTPGLLPDDTTLVVLRRRMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ1</accession>
    <name>Q1CWJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557038.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7119"/>
    <dbReference type="EnsemblBacteria" id="ABF91814">
        <property type="protein sequence ID" value="ABF91814"/>
        <property type="gene ID" value="MXAN_7119"/>
    </dbReference>
    <dbReference type="GeneID" id="41364293"/>
    <dbReference type="KEGG" id="mxa:MXAN_7119"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_7"/>
    <dbReference type="OMA" id="NSMAGQN"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="50765" checksum="3583A82087C4582B" modified="2006-07-11" version="1">MSESSPVGFEPVPAEARGPPEEGPQGFWASVKEAIHGTERDLTRLPVRSAIFLLAVPMVLEMMMESVFAVVDVFFVGRLGADAVAAVGLTESLLTIIYAASAGLSIGATALVSRRIGEGDPERAARTAVQAVGLGVVLSIPVSVAGVYFARPLMTLMGGSPWVLEHGIRYTQVMLGGMGSVLLLFLINAIFRGAGDAAIAMRVLWLANAINIVLAPLLIFGVGPFPELGVMGAAVATTFGRSCGVAYQLYRLARGSGRLRLRREHLRLEPGTMLAMLRMSGAGTAQALVGTTSWVVLARIVATFGSAAVAGYTIALRIVLFALLPSWGLSNAAATMVGQSLGAGKPERGEHAVWTAGRINAVFLGSLGLLFVLAANPVVGIFTNDAAVMKEAVLALRILSASFLFYAFGMVLTQAFNGAGDTTTPTVLNICCFWLLELPLAWVLSGPLGLGPPGAFLSISVAFSVMALVAVVLFRRGTWKHRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ7</accession>
    <name>Q1CWJ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557032.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7113"/>
    <dbReference type="EnsemblBacteria" id="ABF88984">
        <property type="protein sequence ID" value="ABF88984"/>
        <property type="gene ID" value="MXAN_7113"/>
    </dbReference>
    <dbReference type="GeneID" id="41364287"/>
    <dbReference type="KEGG" id="mxa:MXAN_7113"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035802_0_0_7"/>
    <dbReference type="OMA" id="NCAHCHN"/>
    <dbReference type="OrthoDB" id="760731at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022269">
        <property type="entry name" value="CHP03806_HNE0200"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03806">
        <property type="entry name" value="chp_HNE_0200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187995" evidence="2">
        <location>
            <begin position="27"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="45097" checksum="D13516FDD13CAF7C" modified="2006-07-11" version="1">MKNGRMYRPFIPGLGLAAMLVTAALASCSGDEGGVEPTPDGGGGSTVDSGLPPEDSGTPDAGTGDAGEDAGTPEDAGTNEDAGTPDAGPAFPPNTLSGFGLFTGTPATGGLQPVEGNIPYELTTPLFSDYSVKSRTLYIPPDAQAGYSANDVLDLPVGTIITKTFSFPADLRVPEENVRAIETRVLVHRPGGWEAFPYFWNEAQTEATLANGGRVVRGVRFIGEDGVERTLDYLVPSKNQCLKCHHLQDAQENQVLLPIGVKARYLNQDHDYGDGPINQLQHLANLGRLTGLPPVNQVPRAPNAFNAEDGTLEQRARTYLDINCAHCHNPKGTAGTTSRLFLNVDNTEEFTLGVCKRPGSAGGGVGGEFDIVPGSHSVSILWYRMHTEESGKMMPELGRVLRHDQGSRLISDWIDAMDPRSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWN1</accession>
    <name>Q1CWN1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92385">
        <property type="protein sequence ID" value="ABF92385"/>
        <property type="gene ID" value="MXAN_7079"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7079"/>
    <dbReference type="eggNOG" id="ENOG502ZQZ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1747085_0_0_7"/>
    <dbReference type="OMA" id="TEPYEYE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="17246" checksum="05D4B10269C8C3E6" modified="2006-07-11" version="1">MMGQGLKVAFSCRGQGWLELSFEVQGRHVSSTFSDVPFDSLRHLAESLLGFYENGLPGTTQLNGEPEVDELRLEPGPGLQAALRLVRLPDRTRMQDTEAERFRMEAPARDIVLSFWRALRRLEGEFAANGTTIWRFEFPHRAVSRLGDALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWU5</accession>
    <name>Q1CWU5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas1</name>
        <name evidence="9" type="ORF">MXAN_7015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556934.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7015"/>
    <dbReference type="EnsemblBacteria" id="ABF92857">
        <property type="protein sequence ID" value="ABF92857"/>
        <property type="gene ID" value="MXAN_7015"/>
    </dbReference>
    <dbReference type="GeneID" id="41364191"/>
    <dbReference type="KEGG" id="mxa:MXAN_7015"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_7"/>
    <dbReference type="OMA" id="AYKLIKH"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09721">
        <property type="entry name" value="Cas1_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="37866" checksum="22E40A916AB1509F" modified="2006-07-11" version="1">MTTALNTLFITAEGTRLNKEGECVVVTVQDQKKAEVPLRHLRSVVCLTRAWLTPELMESCLEAGIHVSFFGMTGRFLARVEGVPGGNVLLRRQQYRAADDIARSVAISRALVVGKLGNARQFVLHARRDAAPERQEALSETARRLSEHLRALTRVEDLVQVRGLEGIAARDYFESFPALLKKSAQGFEFDGRNRRPPRNPLNAMLSFGYALLAQDCAGALTGVGLDPAVGFLHEDRPGRLSLALDLMEEFRAPVVDRLVFSLVNRGQLKPGDFRTESAGAVLLKDDARKTFLVAYQEAKQVGVRHAFLGQETTWGMAPHLQALLLARHLRGELDGYPPFAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXT1</accession>
    <name>Q1CXT1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6675"/>
    <dbReference type="EnsemblBacteria" id="ABF88622">
        <property type="protein sequence ID" value="ABF88622"/>
        <property type="gene ID" value="MXAN_6675"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6675"/>
    <dbReference type="HOGENOM" id="CLU_2396595_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="93" mass="10361" checksum="7CF0F5AB34DE00F0" modified="2006-07-11" version="1">MPRELPQDRFCPWREEAEDLKARLTSLEAKMATLERHVFRRRAEKLPTVADELREDGGRSAAPGGPPLGESGGWQSQTHSRDNGSLAARPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX0</accession>
    <name>Q1CXX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556561.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CXX0"/>
    <dbReference type="STRING" id="246197.MXAN_6636"/>
    <dbReference type="EnsemblBacteria" id="ABF92798">
        <property type="protein sequence ID" value="ABF92798"/>
        <property type="gene ID" value="MXAN_6636"/>
    </dbReference>
    <dbReference type="GeneID" id="41363833"/>
    <dbReference type="KEGG" id="mxa:MXAN_6636"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_23_7_7"/>
    <dbReference type="OMA" id="FRWLTWL"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="592" mass="63259" checksum="90A22BE6E5ABD14E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY86</accession>
    <name>UPPP_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP</name>
        <name type="ordered locus">MXAN_6514</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556445.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CY86"/>
    <dbReference type="SMR" id="Q1CY86"/>
    <dbReference type="STRING" id="246197.MXAN_6514"/>
    <dbReference type="EnsemblBacteria" id="ABF89199">
        <property type="protein sequence ID" value="ABF89199"/>
        <property type="gene ID" value="MXAN_6514"/>
    </dbReference>
    <dbReference type="GeneID" id="41363722"/>
    <dbReference type="KEGG" id="mxa:MXAN_6514"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_7"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000250246" description="Undecaprenyl-diphosphatase">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="297" mass="32107" checksum="0E2AF378FD6FD8F8" modified="2006-07-11" version="1">MSLLEAIVLGLVQGLTEFLPISSTAHLRIAPELFGWRDPGAAYSAVIQLGTVAAVLIYFRKDIVSLVAAFFRGLARREPFGTLEARLAWFVLVGTLPVGIAGLTLKKFIENEFRSLYVISGSLIVLALILLVVEKRASHQRTLADMRWKDGILIGMWQALALIPGASRSGTTLTGGLSLGLKREDAARYSFLLSIPATTLAGVFELKHLLEAETRPSAMALWVGTLVAFASGMAAIAWLLRFLRTRTTLVFVVYRVALGVLLLVLLQTGKLSPMSGVENVEVPGEPGAPPVEKQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYK1</accession>
    <name>Q1CYK1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 3-oxoacyl-acyl carrier protein reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556330.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6398"/>
    <dbReference type="EnsemblBacteria" id="ABF86916">
        <property type="protein sequence ID" value="ABF86916"/>
        <property type="gene ID" value="MXAN_6398"/>
    </dbReference>
    <dbReference type="GeneID" id="41363609"/>
    <dbReference type="KEGG" id="mxa:MXAN_6398"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="WHEVLAT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="26274" checksum="859E95D60F5F3F25" modified="2006-07-11" version="1">MSHPETNTPFLDGFLHQQVVLVTGAGQPIANAIARRHGKAGARLALVFLPEHEAEATALARELSAELALACESSDAQAVGAVVRRVATELGRIDLLINASLSRATGRLSDLSAEQWKAVLDRQLSGTAWFCKEVIRPMMRKRSGRIVNLLDAASGGASRVAAEGITAMTRALANEVARQGISVNTLAVQLLEEETAHLTPAQRERLDGELGPLGRLGSAEEVAEAVLFLGSSAANLTTGQRLSATGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYK3</accession>
    <name>Q1CYK3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556328.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6396"/>
    <dbReference type="EnsemblBacteria" id="ABF89099">
        <property type="protein sequence ID" value="ABF89099"/>
        <property type="gene ID" value="MXAN_6396"/>
    </dbReference>
    <dbReference type="GeneID" id="41363607"/>
    <dbReference type="KEGG" id="mxa:MXAN_6396"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815920_0_0_7"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="3">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoacyl-synt_C" evidence="4">
        <location>
            <begin position="221"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="35281" checksum="473DEDA01138365D" modified="2006-07-11" version="1">MSRRIVISGLGAVCPQATGPTALWERFSQGDAGPPSSLAERIPDAAFAKQSAQLRHMDRLGRIALTATTLAIEDAGPGNPLQTGIAFGSSYGCLPTNAEYLEAILERGGRYGNPVVFQNTVTNAATGYISMVHDLRGPTATLCSGHAAGLEALRFGCQQIEEGQAERMVVVGADTLSPMLLAGIALPEGMRVSEAACALVLEEHTHALTRGAHRHAEVLGTGHRGGSLTNQAHTLARAVRDAMHLARIEPEQLSAVFSCASGRGDFDGWEQRGLHEALGAHAAKVPVSCPKDVLGETFSTAGMLAVVLATRALDKGCALVTALGGEGSALAVVLRGGAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM5</accession>
    <name>Q1CYM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Medium-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">alkK</name>
        <name evidence="3" type="ORF">MXAN_6374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556306.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6374"/>
    <dbReference type="EnsemblBacteria" id="ABF88458">
        <property type="protein sequence ID" value="ABF88458"/>
        <property type="gene ID" value="MXAN_6374"/>
    </dbReference>
    <dbReference type="GeneID" id="41363587"/>
    <dbReference type="KEGG" id="mxa:MXAN_6374"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_7"/>
    <dbReference type="OMA" id="FAIPSMG"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="449"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="59857" checksum="592DACD5B449E7F5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU8</accession>
    <name>Q1CYU8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556233.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6300"/>
    <dbReference type="EnsemblBacteria" id="ABF91430">
        <property type="protein sequence ID" value="ABF91430"/>
        <property type="gene ID" value="MXAN_6300"/>
    </dbReference>
    <dbReference type="GeneID" id="41363516"/>
    <dbReference type="KEGG" id="mxa:MXAN_6300"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073040_0_0_7"/>
    <dbReference type="OMA" id="DYAGRGH"/>
    <dbReference type="OrthoDB" id="1539910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="34826" checksum="8853DCC0D774FEDF" modified="2006-07-11" version="1">MRGTMRSRVSPEQFRQTSLFPRGLSAASRAAEGTAAPRPEGGPAAPVAPAPRPVAPPVPMPQRNLPPDDAPRIVTRPPTREELWSRAESLAWRLSAELGMPVRLSVTDNRSTMVSFRRGSAVLALRLHHMFLDAPEPVVRAVADYAGRGHRTAGAILDEYIRGQQPRIRQMRRESDADLNPRGRCFDLQALYDATNRDFFQGLIQARIGWGRMPPRRRRKSIRLGVYDHQTREIRIHPALDTPEVPSFFVEFIIFHEMLHQLFPSTGRGGRRVHHPRAFRERERTFPHYAAALRWERENLGVLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ32</accession>
    <name>Q1CZ32_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556154.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6210"/>
    <dbReference type="EnsemblBacteria" id="ABF92550">
        <property type="protein sequence ID" value="ABF92550"/>
        <property type="gene ID" value="MXAN_6210"/>
    </dbReference>
    <dbReference type="GeneID" id="41363438"/>
    <dbReference type="KEGG" id="mxa:MXAN_6210"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047003_2_0_7"/>
    <dbReference type="OMA" id="MQTWAGL"/>
    <dbReference type="OrthoDB" id="1819400at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="440" mass="48159" checksum="DA5FAF5DA5E5AB08" modified="2006-07-11" version="1">MGSPDPGAFASHAQVPPDMIPFLMMLPMLVPAGVKRGRSSKARREGGLSPVPSPTEESGSAPPVRASSRRRLPAQVLGQRALNRALLQRQWLLQRSRAGVMEALEHLVGLQAQATHPPYGALWTRLNGFQQEALTRLMTERQVVRAGMMRGTLHLVTARDCLALRPVLQPALDRGLKHSSHGKQLAGVEVQALVAEGRALLEARPSPRGELGQRLQERWPGHDASALSLGFSSLEPLVTVPPCGTWGHGERMVYATAESWLGQRFEPAAPPDALVMRYLAAFGPASAKDLQAWSGLPRMGAVLERLRPELRAFRDEHGVELFDIPNARRPDPDTPAPVRFLSEFDSVLLAHADRTRIISDAARKRVFTINGIVRATILVDGFVRGTWRIERARGTATLCITPFARLSREDRAALSDEGGRLLAFAASDGQHADIRFERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ95</accession>
    <name>Q1CZ95_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6147"/>
    <dbReference type="EnsemblBacteria" id="ABF86137">
        <property type="protein sequence ID" value="ABF86137"/>
        <property type="gene ID" value="MXAN_6147"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6147"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274626_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1166" mass="117932" checksum="21B744863FBFE87C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE4</accession>
    <name>Q1CZE4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6094"/>
    <dbReference type="EnsemblBacteria" id="ABF87594">
        <property type="protein sequence ID" value="ABF87594"/>
        <property type="gene ID" value="MXAN_6094"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6094"/>
    <dbReference type="eggNOG" id="ENOG5033HF2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675988_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBP2-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="157" mass="16766" checksum="C8D4BFFEACCB854A" modified="2006-07-11" version="1">MARRTRIIEGTWNCTSCDTKSIRARHKRCPQCNNPRELTGKESEFDFGGVDATSGKSLREGVTDAAALALAKAGEDWFCAFCGAATRGDTTRCKHCGAERTDDAKAAPRQAFDEPPPPPPAAVTSREAQGTDAPGARLAVPLLPRLQCLRPVGRQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZN6</accession>
    <name>Q1CZN6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555951.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6002"/>
    <dbReference type="EnsemblBacteria" id="ABF89538">
        <property type="protein sequence ID" value="ABF89538"/>
        <property type="gene ID" value="MXAN_6002"/>
    </dbReference>
    <dbReference type="GeneID" id="41363241"/>
    <dbReference type="KEGG" id="mxa:MXAN_6002"/>
    <dbReference type="eggNOG" id="COG4587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084465_1_1_7"/>
    <dbReference type="OMA" id="YLIDFPA"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="29768" checksum="70E022B53AF4CC04" modified="2006-07-11" version="1">MSARTTLRAFPTLLRVGFAEAVAYRAEMLIWVLSTTMPLVNMVLWMAVSREAPVGRFGEADFISYFLATFAVRQLATSWAAWLINWEVKQGTLAMRLLRPISPLWAYAVESIAAFPMRLMVAVPVMLLSVALVGQKAVPQHAWQWGFVVLSVIGGWAVAFLANVAIGALCFFLESSQKVLEVWLVLFFVCSGYMYPVELLPPTLRTIIDWLPFRYQIGVPVEMLTGAYGWEESLRLLAAQWAWVAVLGALAAVTWKQGVRRFAAFGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ8</accession>
    <name>TTCA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-cytidine(32) 2-sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Two-thiocytidine biosynthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiocytidine biosynthesis protein TtcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ttcA</name>
        <name type="ordered locus">MXAN_5980</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:57048"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:14821"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:141453"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:57049"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TtcA family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555929.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZQ8"/>
    <dbReference type="SMR" id="Q1CZQ8"/>
    <dbReference type="STRING" id="246197.MXAN_5980"/>
    <dbReference type="PRIDE" id="Q1CZQ8"/>
    <dbReference type="EnsemblBacteria" id="ABF88520">
        <property type="protein sequence ID" value="ABF88520"/>
        <property type="gene ID" value="MXAN_5980"/>
    </dbReference>
    <dbReference type="GeneID" id="41363219"/>
    <dbReference type="KEGG" id="mxa:MXAN_5980"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_0_0_7"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01850">
        <property type="entry name" value="TtcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012089">
        <property type="entry name" value="tRNA_Cyd_32_2_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000348770" description="tRNA-cytidine(32) 2-sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PP-loop motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="284" mass="31823" checksum="7DCEAC342E0E1C34" modified="2006-07-11" version="1">MAAPMNDVQRLEKSLLGHMGRAIADHRLIEDGDRIMVGVSGGKDSYTMLHLLRELQRRAPVKFELLAVNLDQGHPGFPADKLEAYFQREGYPYKLLKEDTYSIVLEKTPPGKTQCSVCSRMRRGILYTAAVELGCTKIALGHHRDDLIHTLLLNLFFAGSIKAMPPLLRSDDGRNVVIRPLCYAPEKDIAKFAELMAFPIIPCDLCGTQENLQRKRMQRLMEELGKEIPNVRQSVLNAMANVRPSHLLDKTLNPDPLHASEEGATTTEPKDTQGSASPWLESRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ4</accession>
    <name>Q1CZZ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555843.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5892"/>
    <dbReference type="EnsemblBacteria" id="ABF91139">
        <property type="protein sequence ID" value="ABF91139"/>
        <property type="gene ID" value="MXAN_5892"/>
    </dbReference>
    <dbReference type="GeneID" id="41363131"/>
    <dbReference type="KEGG" id="mxa:MXAN_5892"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057834_0_0_7"/>
    <dbReference type="OMA" id="MTQHGFA"/>
    <dbReference type="OrthoDB" id="710313at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="31290" checksum="1A329C7932EC3E6F" modified="2006-07-11" version="1">MKGPFPGIAGLDTYALVDGGCRVEVLPSRGALVSRMCVDGDELLYLDEATVADPAKNVRGGIPVLFPNAGPLPGDTYSVDRQQYTLPQHGFARKLPWKVRQADTSRLVVELSSNEETLRHFPWRFDARLTFSLAGQRLTLESAFENQDTRPMPLHLGFHPYFRVPDAAKAQAGVDTDATHAWDNWRKQDVNVTGLNLTEEEVDLHLKDHSKPGTTLERGPGLKPIRLSWSPEYRVLVVWTQRGKDFVCVEPWTAAKGALATGEGLPHVQPGTRTSLRFDIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D026</accession>
    <name>Q1D026_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555811.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5860"/>
    <dbReference type="EnsemblBacteria" id="ABF91729">
        <property type="protein sequence ID" value="ABF91729"/>
        <property type="gene ID" value="MXAN_5860"/>
    </dbReference>
    <dbReference type="GeneID" id="41363099"/>
    <dbReference type="KEGG" id="mxa:MXAN_5860"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_0_7"/>
    <dbReference type="OMA" id="ETWVYPG"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="25598" checksum="350FDF1A5BC9CE7C" modified="2006-07-11" version="1">MLFRQLFDTTSSTYTYLLGDEEQGTALLIDPVAEKLDRDLTLLRELGLSLTHALDTHVHADHVTASGLLRARTGAKVVSGITGAPCADIHVKHGDTLRAGTFTLQVLATPGHTDDSVSYLLGDRVFTGDALLIRGNGRTDFQNGNAGTLYDSITQVLFALPDETLVYPAHDYRGLTVTTIGEEKRHNPRVAGRSRDGFIQLMNNLGLPKPKLIDVAVPANRACGLTAPVRARGSFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D097</accession>
    <name>Q1D097_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Riboflavin kinase</fullName>
                <ecNumber evidence="12">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">FMN adenylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">ribF</name>
        <name evidence="14" type="ORF">MXAN_5789</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="12"/>
    <dbReference type="EC" id="2.7.7.2" evidence="12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555740.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5789"/>
    <dbReference type="EnsemblBacteria" id="ABF90889">
        <property type="protein sequence ID" value="ABF90889"/>
        <property type="gene ID" value="MXAN_5789"/>
    </dbReference>
    <dbReference type="GeneID" id="41363032"/>
    <dbReference type="KEGG" id="mxa:MXAN_5789"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_1_7"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 12" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="13">
        <location>
            <begin position="177"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF90889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="32943" checksum="982A595C0D2495C1" modified="2006-07-11" version="1">MKVYPAVADAGRALAGQALALGNFDGVHVGHQALFAEARRHGRAAAFTFNPHPGKVLQPELAPKLITLLPRKLELFEELGLDAAVVQPFSREYARTPPADFEAALFDALGVAHVVVGSDFTYGSARRGTAETLREAAARRGATVHVVPPVTVDGVVASSSRVREYILEGRVSAARRLLGRPFDLDGTVVTGAGRGRGIGFPTANVDTQNELRPAPGVYAIRVQLPGESKGTWHGGAANIGVKPTFGGTEVTIEAHLLDFTGDLYGKELRVQFLDRLRPEQRFGSVVELTGQIKRDVEAARAVIAREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0L2</accession>
    <name>Q1D0L2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555626.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5673"/>
    <dbReference type="EnsemblBacteria" id="ABF90862">
        <property type="protein sequence ID" value="ABF90862"/>
        <property type="gene ID" value="MXAN_5673"/>
    </dbReference>
    <dbReference type="GeneID" id="41362917"/>
    <dbReference type="KEGG" id="mxa:MXAN_5673"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1873207_0_0_7"/>
    <dbReference type="OrthoDB" id="2145543at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="14332" checksum="468CE002682FD1A6" modified="2006-07-11" version="1">MVHYAEHDAYEPVFAKLNHEIPRGNHFAFLAGVEPADARDTAGAAAVEDAVAVGVDVATNPALKAIQFGELPVLVAKQVGLSGECPDCAITAACVANLDRDGDLDVWLISSKELTGLDGQPVNPGEPLHFMNDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N6</accession>
    <name>Q1D0N6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555602.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5648"/>
    <dbReference type="EnsemblBacteria" id="ABF88989">
        <property type="protein sequence ID" value="ABF88989"/>
        <property type="gene ID" value="MXAN_5648"/>
    </dbReference>
    <dbReference type="GeneID" id="41362894"/>
    <dbReference type="KEGG" id="mxa:MXAN_5648"/>
    <dbReference type="eggNOG" id="COG3190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1853057_0_0_7"/>
    <dbReference type="OMA" id="WWLHRRG"/>
    <dbReference type="OrthoDB" id="1997601at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="15304" checksum="40B5B208F53FE1AD" modified="2006-07-11" version="1">MSPVMNAQRFVHSPRSRLLLAGALVLGLAVMGPVAGVSTTMAARWLLGVVALAVLGWWLHRRGAVVTGASTAPRLNVVSRAGLSQRCGVALVEVDGRSYLVAFGDAFAEIRETAAPAPEFGHVLAQARRPMPRSRTIRGRREGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q5</accession>
    <name>Q1D0Q5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, iron-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555583.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5629"/>
    <dbReference type="EnsemblBacteria" id="ABF86104">
        <property type="protein sequence ID" value="ABF86104"/>
        <property type="gene ID" value="MXAN_5629"/>
    </dbReference>
    <dbReference type="GeneID" id="41362875"/>
    <dbReference type="KEGG" id="mxa:MXAN_5629"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_7"/>
    <dbReference type="OMA" id="IRFGPGC"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="394" mass="41658" checksum="FC534BD51B8061F2" modified="2006-07-11" version="1">MKPFDIPSEPRVTEMAWPTRIVFGAGALLRLPAQAQRLGIQRPLLVTDAGVVKAGLAARVADVLNTAGLACEVFDRVEPNPTERDVFAGLEAYRSHSCDGIVALGGGSALDAGKLIQLLTTHEPPLSRYDDAKGGDQYVRDDLPPLIAIPTTAGTGSEVGRSGVVTLEDTGRKTVIFSPYLLPRAAICDPELTLGLPPGITAATGMDAFTHCLEAYLANGFHPLADAVAIDGIYRVGRSLETAVRDGKDLAARTDMMVAAMEGAMAFQKGLGACHALAHALTPVSNVHHGLANAIVLPVVMEFNRAVCTARLARVAVALGDTTQAREEVLAGNAIDRVRKLNAAVGIPSRLRDAGVQEKDLERIAEKAFQDASHLSNPRKVSQADLLALAREAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D108</accession>
    <name>Q1D108_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonizing lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5522"/>
    <dbReference type="EnsemblBacteria" id="ABF85987">
        <property type="protein sequence ID" value="ABF85987"/>
        <property type="gene ID" value="MXAN_5522"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5522"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062016_0_0_7"/>
    <dbReference type="OMA" id="YYFSWSG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188139" evidence="1">
        <location>
            <begin position="36"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="33988" checksum="0C1140CCE501A02B" modified="2006-07-11" version="1">MDPSPEQEPLLMRNAVRTLVLAVAALGLWSQPALANTQTQTRYPIVLAHGMAGFDSLFGVYDYFYGIGSDLRSGGATVYVTSVPQFNTTEQRGEALLAQVKDIVARSGKGKVNLIGHSHGGLDVRYVAAVRPDLVASVTTVGSPHKGADLADYLRANLRGGSFTESVLAYFANNLGTVLGLLSGKTNPQDAIGALAALSKSGTAAFNQKYPAGIPSSSCGQGAATGTQGQRYYSWSGTDPFTNMLDVSDYPMKLSSFFYSEANDGLVGKCSSHFGTVLRDNYDMNHLDEVNQVLGLTAFFTNPKTVFRNHANRLKGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1P3</accession>
    <name>Q1D1P3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555245.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5278"/>
    <dbReference type="EnsemblBacteria" id="ABF87037">
        <property type="protein sequence ID" value="ABF87037"/>
        <property type="gene ID" value="MXAN_5278"/>
    </dbReference>
    <dbReference type="GeneID" id="41362555"/>
    <dbReference type="KEGG" id="mxa:MXAN_5278"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058223_0_0_7"/>
    <dbReference type="OMA" id="YATYCPS"/>
    <dbReference type="OrthoDB" id="1284462at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="40539" checksum="38D1B94233B69088" modified="2006-07-11" version="1">MDTSALMQRSCDTEGRAPSHLREKPVTINEMNLRLSIRSLLILSLTVAPALSGCGSDDVDPTPDAGFDAGVQPDAGIEPDAGIEPDAGIEPDAGTEPDAGTEPEPEPDAGTEPDAGTEPDAGTEPDAGTEPDAGTEPDAGTEPDAGTEPDAGTEPDAGTDSDGGTDPDAGTDSDGGTAPDAGTDSDGGTDPDAGTDPDAGTDPDGGTDPDAGTDSDGGTAPDAGTEPDPFTVCEGECQETATTIRLGENQRVLTSAYFGYEETDNPEAPWELWIELNNSAPGECPSEDSPLPPQLVNVHKVRMPVDATPQVGSMPGEPTATLVDFEGVLTTAYFLHSTSLTFTPVAASLCPTCVLSGTPPESHFVAFDLNGLYANGAITGHGYATYCPSLDSFKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R0</accession>
    <name>Q1D1R0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555228.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5261"/>
    <dbReference type="EnsemblBacteria" id="ABF86474">
        <property type="protein sequence ID" value="ABF86474"/>
        <property type="gene ID" value="MXAN_5261"/>
    </dbReference>
    <dbReference type="GeneID" id="41362538"/>
    <dbReference type="KEGG" id="mxa:MXAN_5261"/>
    <dbReference type="HOGENOM" id="CLU_2194100_0_0_7"/>
    <dbReference type="OMA" id="AACQSNM"/>
    <dbReference type="OrthoDB" id="1933408at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188157" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="11319" checksum="622A0A9445D312DB" modified="2006-07-11" version="1">MNASRLAASWAAALSLSLIACGGGDASLDVPEGEAPATVEQGLGVPPQCPNGDLIYWVENVQACTMKCGTTRKPGKPSTQYAACQSNMTGTRTLINVQYCLPGCEIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U9</accession>
    <name>Q1D1U9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fumarate reductase, iron-sulfur protein</fullName>
            <ecNumber evidence="9">1.3.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">frdB</name>
        <name evidence="9" type="ORF">MXAN_5222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.1" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555189.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5222"/>
    <dbReference type="EnsemblBacteria" id="ABF87091">
        <property type="protein sequence ID" value="ABF87091"/>
        <property type="gene ID" value="MXAN_5222"/>
    </dbReference>
    <dbReference type="GeneID" id="41362504"/>
    <dbReference type="KEGG" id="mxa:MXAN_5222"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_7"/>
    <dbReference type="OMA" id="AFASDCR"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="270" mass="28950" checksum="B62C9B631A034090" modified="2006-07-11" version="1">MRFVLQIWRQERPRSLGAFRRYEVSDITADMSFLEMLDVLNEQLAAKGEAPVAFESDCREGICGTCGVMINGAAHGPLGGAAVCQLHMRRFPDGALLVIEPWRARAFPVLKDLIVDRSALDRIIGAGGFISVPTGAAPEASTRAVSKQNADGAMDAAACIGCGACVAACPNASAALFTGAKVSHLALLPQGRPERERRVLSMVARMDEEGFGNCTWHGECQAACPKSISIDAIALMNHEWLRASIASQREVWREPEADAQSQDPERGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2A7</accession>
    <name>Q1D2A7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90213">
        <property type="protein sequence ID" value="ABF90213"/>
        <property type="gene ID" value="MXAN_5062"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5062"/>
    <dbReference type="HOGENOM" id="CLU_1041432_0_0_7"/>
    <dbReference type="OMA" id="PFYRWFL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="29926" checksum="A33072878DDF3106" modified="2006-07-11" version="1">MDPSAWMTRSPPDDYGIPADSMSTHEEVELEMERLLLRTVPGLEEQWRGAVPVTIEKIERIVGRPLPPFYRWFLSRMGQSMGPLAYPTLDFSAERVLACYAQKLVKPEPRFLLIAYESDAMMPLHLFYDFNAPSRNDAMVTSREARGKELTDAFETLREMLAWGALSLFRIDRAPHTCSGSLKGDTTDFLVDLDPVMSSLGFIQPIPTGPLCRLYERPDAVMVCTGTPRAGTGNRRAFDLGGNSVGRLRRILGEISSARVAELQVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2C9</accession>
    <name>Q1D2C9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555015.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5039"/>
    <dbReference type="EnsemblBacteria" id="ABF87386">
        <property type="protein sequence ID" value="ABF87386"/>
        <property type="gene ID" value="MXAN_5039"/>
    </dbReference>
    <dbReference type="GeneID" id="41362324"/>
    <dbReference type="KEGG" id="mxa:MXAN_5039"/>
    <dbReference type="eggNOG" id="COG3564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134343_1_0_7"/>
    <dbReference type="OMA" id="GSAPMCF"/>
    <dbReference type="OrthoDB" id="1912908at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008497">
        <property type="entry name" value="DUF779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05610">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009151">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15388" checksum="E8BCF6B296A5AEF3" modified="2006-07-11" version="1">MGGAGAGPGTGGQDGATAVARVDVTPEAAAVIRQLRATHGPLMFHQSGGCCDGSAPMCYPVGDFRVGQRDVFLGEVEGCPVYIGGAQFEYWQHTHLTLDVVKGRGAGFSLESPLGVRFLTRSRVFTDEEYERVKNAPPPRRGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F2</accession>
    <name>Q1D2F2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86998">
        <property type="protein sequence ID" value="ABF86998"/>
        <property type="gene ID" value="MXAN_5016"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5016"/>
    <dbReference type="eggNOG" id="COG4304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124837_1_0_7"/>
    <dbReference type="OMA" id="ENINHLM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016630">
        <property type="entry name" value="UCP015278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10004">
        <property type="entry name" value="DUF2247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015278">
        <property type="entry name" value="UCP015278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17982" checksum="C7EDB012DD2CA4B9" modified="2006-07-11" version="1">MRTRLTWREVLFGVDNELLSSEVPVEMAVEQLGIEDWPVRALAELADLEPWKSPRSCVEALAGTEASQDAEAIKSKWLYLVLAWVFINREHFSDPLEMGEKIYADFGYPERVARFIRYMPSDEPDLGSREMNERRLYSQWKSYLDELSSEYAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Y6</accession>
    <name>Q1D2Y6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodB</name>
        <name evidence="9" type="ORF">MXAN_4826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554812.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4826"/>
    <dbReference type="EnsemblBacteria" id="ABF87575">
        <property type="protein sequence ID" value="ABF87575"/>
        <property type="gene ID" value="MXAN_4826"/>
    </dbReference>
    <dbReference type="GeneID" id="41362124"/>
    <dbReference type="KEGG" id="mxa:MXAN_4826"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_0_7"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="89"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21646" checksum="798F11E7EFEA498B" modified="2006-07-11" version="1">MSFTLPDLPYKKDALAPHMSAETLEFHHDKHHAAYVNNLNKLLDGKPEANKSLEEVILSSDGGVFNNAAQVWNHTFFWQCMKPAGGGKPTGELAAAIDRDFGSFEKFKEEFSTAAATQFGSGWAWLVLEGGKLKVTKTGNADLPMKHGQKALLTIDVWEHAYYIDFRNARPKFIETFLTHLVNWDFVAQNFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D353</accession>
    <name>Q1D353_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheA</name>
        <name evidence="8" type="ORF">MXAN_4758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554745.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4758"/>
    <dbReference type="EnsemblBacteria" id="ABF85910">
        <property type="protein sequence ID" value="ABF85910"/>
        <property type="gene ID" value="MXAN_4758"/>
    </dbReference>
    <dbReference type="GeneID" id="41362057"/>
    <dbReference type="KEGG" id="mxa:MXAN_4758"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_7"/>
    <dbReference type="OMA" id="HILPVIW"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
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            <end position="722"/>
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    </feature>
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            <end position="412"/>
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    </feature>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
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            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF85910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="862" mass="90733" checksum="1F28F616F0FAAF40" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3E9</accession>
    <name>Q1D3E9_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Pilus biogenesis protein, TadE family</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_4658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4658"/>
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        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87958">
        <property type="protein sequence ID" value="ABF87958"/>
        <property type="gene ID" value="MXAN_4658"/>
    </dbReference>
    <dbReference type="GeneID" id="41361958"/>
    <dbReference type="KEGG" id="mxa:MXAN_4658"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="43932" checksum="9D281F87BD2653B9" modified="2006-07-11" version="1">MRARLQMRSRSRGAATVEFALSVPLLVMILMFSMYLTELVRAKLKLQEAARYAVWEMTSYALSDFANGKHDDAFEDARREAHKEFVERYKDMDSVEPNGTGGNFIARYTDVTATISNKEIALLESGMLSRPSTSEGGGLAGAILSPLNNGMGWVLNQWGFNNKGWVESEVEMNYENVILPTRYLDKSGGNGGFFKENMMGGRDLGSLRLKSKYSMYANGWHMPDGGDAIVRGRRAGQHTGGSLSQPHGLYRQVDRMVFLGFASTLDSLGIGAILDVVASVLPNFLGTFVVSRNYGVGASQKGDCTGLAQYDAKASSGLHVMHKRSFELTDHERPNCFDTAPFRDEMTYANSNYIKVFNARGEFYMGCKRAMADDPTDPDARPEATENDEQDLKVPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3H7</accession>
    <name>Q1D3H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4630"/>
    <dbReference type="MEROPS" id="S54.A08"/>
    <dbReference type="EnsemblBacteria" id="ABF89821">
        <property type="protein sequence ID" value="ABF89821"/>
        <property type="gene ID" value="MXAN_4630"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4630"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="SGMILGW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="55"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="23487" checksum="E09CFAFF4EFD13C5" modified="2006-07-11" version="1">MPGPPQPRPWVCYAIIACAVSLFLAEQVLPISQVVRSEHGRMQIPPLGLYGPFVQAGQYWRLLGAVLEHGSPLHLLFNMSVVVTLGFTLERGIGSLRFFGLSLVTALGASTFSLIFDFDVPTVGASGMILGWAGAMLPVATREGRRDLFIWLAQVAVLSLLPFVSWAGHLGGFLFGLPCGLALRMGRQVYARALPILLFLSLVVALYAAHPERRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3I0</accession>
    <name>Q1D3I0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4627"/>
    <dbReference type="EnsemblBacteria" id="ABF89859">
        <property type="protein sequence ID" value="ABF89859"/>
        <property type="gene ID" value="MXAN_4627"/>
    </dbReference>
    <dbReference type="GeneID" id="41361927"/>
    <dbReference type="KEGG" id="mxa:MXAN_4627"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028335_0_0_7"/>
    <dbReference type="OMA" id="QMGEYGR"/>
    <dbReference type="OrthoDB" id="697124at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="498" mass="53140" checksum="94CD27942B0E7DB3" modified="2006-07-11" version="1">MTTRAKGRGETSPADDEFLQQLSRGGELLAAGRVHEAQPFLERAHQLHPRMEKAQNLLGLCYFKLGLYDRAAELYEMLVRDNPVDPTLRVNLGLVYLKTSALQRAAREFETATDLAPEHQKAQNYLGLTLAQMGEYGRAREHFLLAGSDVMAEKMSRAIAGESYAKPASAAVPPLRSAPVEPLVAEPPPPAAEPEEEEEIRFAEDEGPSALSGASASEATDAAADIGVAREAPPESAFEETADTVATSVPLAPVPLTRLHLRKVPATSLAPTSPAPESSPVRDGGRSSLAELAGSVVLPGAEASRPFCAGPGCYTVAVEGELLTRLDGLVALAGQLSFQPEMKRFRGRATDKSFGEGAARMVRARGQGVLYLEPAATRTFLAVDLGEDSAYFRDECVFAFEEPVMFENGRVPSDIAPDLDLVHLRGQGQVLLSLPGPLRAVAVHQEQPVTVPLTHLVGWQGNLTPRMVPVLKSPSGEPLRAAVELGGEGFALIALGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M7</accession>
    <name>Q1D3M7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554573.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4578"/>
    <dbReference type="EnsemblBacteria" id="ABF86758">
        <property type="protein sequence ID" value="ABF86758"/>
        <property type="gene ID" value="MXAN_4578"/>
    </dbReference>
    <dbReference type="GeneID" id="41361878"/>
    <dbReference type="KEGG" id="mxa:MXAN_4578"/>
    <dbReference type="eggNOG" id="COG1711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068472_1_1_7"/>
    <dbReference type="OMA" id="HWGVGVA"/>
    <dbReference type="OrthoDB" id="1339067at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021382">
        <property type="entry name" value="DUF3014"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11219">
        <property type="entry name" value="DUF3014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="30096" checksum="6A9961130AC17246" modified="2006-07-11" version="1">MRHPSEDGRMSNPEVVTKTQRRMHWGVGVAALVMLFAGVGTWLVLRQSATELPHPSMAVIPKPSHPGLAPRAEPPLPSSAEMDALLRTRLARASLMPEFATWLKEQDLLRRFVTVVGNVAQGDSPREAVSFLAPAGTFEARRKAGKLVIEKQSYARYDVIGKVVGSLDMGVLVSTYREVRHLAERLHMETARPGSTFDATLHLAFEQVLAVPVIDGDIEVVPKGAMFVYADPKLEGLTAAQKHLLRMGPQNLRRIQGTVREASQQLTQQASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D438</accession>
    <name>Q1D438_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554413.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4414"/>
    <dbReference type="EnsemblBacteria" id="ABF92714">
        <property type="protein sequence ID" value="ABF92714"/>
        <property type="gene ID" value="MXAN_4414"/>
    </dbReference>
    <dbReference type="GeneID" id="41361727"/>
    <dbReference type="KEGG" id="mxa:MXAN_4414"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_13_7"/>
    <dbReference type="OMA" id="QACSQAF"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="601"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1669"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="2197"/>
            <end position="2302"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2730"/>
            <end position="2804"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3799"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1742"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1704"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2765"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="3906" mass="428892" checksum="43E957603D529F20" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4E4</accession>
    <name>Q1D4E4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554307.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4304"/>
    <dbReference type="EnsemblBacteria" id="ABF88345">
        <property type="protein sequence ID" value="ABF88345"/>
        <property type="gene ID" value="MXAN_4304"/>
    </dbReference>
    <dbReference type="GeneID" id="41361615"/>
    <dbReference type="KEGG" id="mxa:MXAN_4304"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_7"/>
    <dbReference type="OMA" id="VHRWAQE"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="40946" checksum="D0FFF2F6C979C37A" modified="2006-07-11" version="1">MDFSWTHEQVELYDRALAFARAQLPEAAKPSKEALPRDLWQRCGEFGFLGLPVPAAHGGLGLDTLTTARVMEALGRGCVDTGLVFSVGAHLFACVMPILESGDDAQKSRYLPRLCSGEWVGANAISEPEAGSDVFALKTRAVRDGDSYVLDGGKSYVTNGPSADVFLVYAATQPAHGYMGLSAFLVEKDTPGLSVGRAFEKMGLSTSPIAPIYLEGCRVPESARLGAEGQGAAMFKRSMQWERACLFAAYVGVMERVLEQTADFARTRKQFKKALGKNQAISHKLADMKQRLEASRLLLYQACWKMDRGQDAVMEVSLAKLAISEAAIQSGLDAIQIHGGMGYVAETGIERVLRDAIPSAIFSGTSEIQRDIIANQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4M9</accession>
    <name>Q1D4M9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">MXAN_4219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554222.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4219"/>
    <dbReference type="EnsemblBacteria" id="ABF87976">
        <property type="protein sequence ID" value="ABF87976"/>
        <property type="gene ID" value="MXAN_4219"/>
    </dbReference>
    <dbReference type="GeneID" id="41361536"/>
    <dbReference type="KEGG" id="mxa:MXAN_4219"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_7"/>
    <dbReference type="OMA" id="CHMIGNY"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="346"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="465" mass="49673" checksum="24512203C8C23321" modified="2006-07-11" version="1">MAETFDVVIIGSGPGGYVGAIRAGQLGLKTAIIEKDKRLGGTCLHRGCIPTKSLLWTAELFHHVREAADFGVDVSSPAINWPNAMKHKDKIVTKGANGIDFLMKKNKVTVVKGHGRIAGKGKVEVTAADGSKQVLEAKNIILATGSVPKSLPNVPVDHKRVLNSDSILQIDRVPKSIIVLGAGAVGCEFASVFNHVGSKTSIVEYMPALLPIEDADISKELEKIFKRRGIDVHTGSAVEKVEHTADGVRVTMKVGNETKTLEAEILLSAVGRSPVTEDVGLDKTNIQAERGYIKVDSMLRTSEPNVYAVGDIIPTPMLAHMASAECVVAVEHIAGKNPQPINYDLTPSATYCYPEVASVGLTEKKAKERGYDVKVGIAPMGAVTKASISNEATGMIKIVSDRKYDEVLGVHLIGPHATELLAEACVALKLEITTEELANTIHAHPTLSEIVHEGAEATLGHPRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q0</accession>
    <name>Q1D4Q0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CyaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554201.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4198"/>
    <dbReference type="TCDB" id="1.B.17.2.6">
        <property type="family name" value="the outer membrane factor (omf) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90349">
        <property type="protein sequence ID" value="ABF90349"/>
        <property type="gene ID" value="MXAN_4198"/>
    </dbReference>
    <dbReference type="GeneID" id="41361515"/>
    <dbReference type="KEGG" id="mxa:MXAN_4198"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_6_7"/>
    <dbReference type="OMA" id="VFMMKLD"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044179">
        <property type="term" value="P:hemolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028351">
        <property type="entry name" value="CyaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001892">
        <property type="entry name" value="CyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="2" id="KW-0354">Hemolysis</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188222" description="Protein CyaE" evidence="3">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="431" mass="45284" checksum="C4ACDC5DCEB58042" modified="2006-07-11" version="1">MTALALGFLGLVTAPGVGLAQATTTMTTVSLEEAIARALKTSPQVAQAAGTVTTTGAAERSAFGAYLPNLSASANTSLASSQRLDPTTGAVFNAPSDTYSAGLSASWNVFTGGQRGATSKQAQARSSAARAGLIAQRASAVLDVERSYYEVLRAGGLEEVAVSRIERAKQNAEAADRRLAVGSATRSDVLRAKYDLTAAQEALLSAQTQHAAAALSLGRLIGEDGPVDAQPLELQDVSTFALTDEALTDEITAQAPSIQAAEADLRAAEASVKVARSSYLPTVRLSGGYDWFNDEPALNGGRTSWSVRMGLSYPIFDGFVREERVVSARTQASVAQATLSDTRRALRSSVGTSLNQLKLASNRIALATESVAVAQEDLKVQQERYKLGATTIIELLTSQENLVTAEINLVASRFDYRIARAELEALAGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4T8</accession>
    <name>Q1D4T8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554163.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4160"/>
    <dbReference type="EnsemblBacteria" id="ABF87198">
        <property type="protein sequence ID" value="ABF87198"/>
        <property type="gene ID" value="MXAN_4160"/>
    </dbReference>
    <dbReference type="GeneID" id="41361479"/>
    <dbReference type="KEGG" id="mxa:MXAN_4160"/>
    <dbReference type="eggNOG" id="COG3220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484699_0_0_7"/>
    <dbReference type="OMA" id="NDVGWWH"/>
    <dbReference type="OrthoDB" id="212274at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="562" mass="61493" checksum="B25497FA1AE9FE6B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D563</accession>
    <name>Q1D563_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554040.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4031"/>
    <dbReference type="EnsemblBacteria" id="ABF86024">
        <property type="protein sequence ID" value="ABF86024"/>
        <property type="gene ID" value="MXAN_4031"/>
    </dbReference>
    <dbReference type="GeneID" id="41361362"/>
    <dbReference type="KEGG" id="mxa:MXAN_4031"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2332288_0_0_7"/>
    <dbReference type="OMA" id="KGHALAP"/>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="101" mass="10735" checksum="374505281B81CE0E" modified="2006-07-11" version="1">MARSEPKSLESLLPRVLARLAGESGKGHALAPVWEAVVGPHLARHTTPQALHGTTLVVAVTGAQWAQSLESEAASLCEQLNARLGPDTVKSLSFTFQVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D567</accession>
    <name>Q1D567_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554036.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4027"/>
    <dbReference type="EnsemblBacteria" id="ABF89804">
        <property type="protein sequence ID" value="ABF89804"/>
        <property type="gene ID" value="MXAN_4027"/>
    </dbReference>
    <dbReference type="GeneID" id="41361358"/>
    <dbReference type="KEGG" id="mxa:MXAN_4027"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_1_7"/>
    <dbReference type="OMA" id="MQLLGAC"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="34792" checksum="717B15F5C175AD34" modified="2006-07-11" version="1">MDVSRPGKGRLRIAVTGASGDYGRLLLSRLDQDPDVESILVLDVVRPEGDKVEFHRVDLTRYDAESELTDALTERPVDALYHLAFLFGPIRNGSLAHELEVIGTMNVLTAAGRSRLPRLVVPSLTAVYGARGNNPAMLREDSALQGCPHSRFVTDKVEVEGQVRAFRERHPEMRVLVLRFAPVLGPSVDNPATRFLKNPVVPTLMGFDPLWQGLHEDDAARALHLALRADASGEFNIVGRGVMPISGLIQQAGARPLPLPGPLFRAGLHTLDAVGAGTLPVALLDYIHYSWVADGERAESALGFIPLHHVRDAAAALKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A7</accession>
    <name>Q1D5A7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553996.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3986"/>
    <dbReference type="EnsemblBacteria" id="ABF92474">
        <property type="protein sequence ID" value="ABF92474"/>
        <property type="gene ID" value="MXAN_3986"/>
    </dbReference>
    <dbReference type="GeneID" id="41361318"/>
    <dbReference type="KEGG" id="mxa:MXAN_3986"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_3_7"/>
    <dbReference type="OMA" id="RKRWQVG"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="54794" checksum="05D6561FC3C8352C" modified="2006-07-11" version="1">MSSVRAHRVSFAFSDAVPVLSEVDFHLSPGWTGLVGANGAGKSTLLRLLAGELTPTEGHLQFEPSTPTLRLCRQEVEALTPDISAFAESWDSVARRLHGQLGLDVTALERWPTLSPGERKRWQVGAALAAEPHLLLLDEPTNHLDAEARTWLISALRRFRGLGIVVSHDRDLLESLTTSTLRVHHGSARLWPGAYTAARAHWEAEREAEIATHQQARAEQRRAAHLLDQARREQQSADAARHTRKRLKNKHDNDARSMGAKVVAGWAEAGAGRRVGIARRELERVSEAVGEFTADKTVGRSVFLDYVRAPNPWLFTLDVPGLRAGDVELLGPVNLSVSREARVRVEGPNGAGKSTLVRALLENARIPLERVLYLPQDVSADEARATLDAVRALPPEERGRVLSLVAALGVDPERLLASEQPSPGEVRKLLIARGLGQHAWALVLDEPTNHLDLPSIERLEAALREYPGALMLVTHDTSFAQACTSEVWRVEHGQVTVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K7</accession>
    <name>Q1D5K7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553896.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3886"/>
    <dbReference type="EnsemblBacteria" id="ABF86316">
        <property type="protein sequence ID" value="ABF86316"/>
        <property type="gene ID" value="MXAN_3886"/>
    </dbReference>
    <dbReference type="GeneID" id="41361219"/>
    <dbReference type="KEGG" id="mxa:MXAN_3886"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_11_0_7"/>
    <dbReference type="OMA" id="YVLMGAK"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188183" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="5">
        <location>
            <begin position="435"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="599" mass="64105" checksum="6F3C32897C476E30" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5P7</accession>
    <name>Q1D5P7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">xerD</name>
        <name evidence="15" type="ORF">MXAN_3844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553856.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3844"/>
    <dbReference type="EnsemblBacteria" id="ABF87948">
        <property type="protein sequence ID" value="ABF87948"/>
        <property type="gene ID" value="MXAN_3844"/>
    </dbReference>
    <dbReference type="GeneID" id="41361177"/>
    <dbReference type="KEGG" id="mxa:MXAN_3844"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_7"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="106"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF87948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="34182" checksum="BE52B7F069156D14" modified="2006-07-11" version="1">MEGLLDAFIAFIRAERGLSGKTVDAYAADINVYFEDLRSRGVSDVTQARQEDVSAHLSALGKRGLGKRSQARHLAALRGFHRFLVAERMADKDPTEDLDTPRSARKLPSFLTLEEVEQLLAAPDERTSTGVRDKAMLEVLYATGLRVSELCGLGINDVQLTAGYLVAKGKGAKERLVPLGSVAIEKVQAYLAESRPAVLGRRKSQALFVTPRGSGFTRQGFWKLLKRYALKAGILKPLSPHKLRHSFATHLVERGADLRAVQQMLGHADLATTQIYTHVNAARLRSVYDEFHPRSDVFVPKAKKARAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5W0</accession>
    <name>Q1D5W0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553794.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92322">
        <property type="protein sequence ID" value="ABF92322"/>
        <property type="gene ID" value="MXAN_3781"/>
    </dbReference>
    <dbReference type="GeneID" id="41361113"/>
    <dbReference type="KEGG" id="mxa:MXAN_3781"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_4_1_7"/>
    <dbReference type="OMA" id="FICYFIP"/>
    <dbReference type="OrthoDB" id="1200953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="27471" checksum="C1E7963C4160DA51" modified="2006-07-11" version="1">MQELLTNLLGDSQGVFAYATVFGILVACGLGVPLPEDISLILGGFLAHKGAANLSVMMVVGFAGIIVGDSLIYLAGRRLGGRLGREGGGGFFARIVTPEKRAKVEGLFVKHGQKIVCIARFMPGVRAVTYFTAGSVGMSYWRFIFWDGLAALLSAPVFIWLGFHFGGELDTMISKFKEGQFAVMGVLAVAAIGYFVWRRRQAAQRAQAAAIVEPVAVPALVHESVAAPLRPQVSSTGDALFVAAPEQAAADSSHELQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D623</accession>
    <name>Q1D623_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase, RluA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553731.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3714"/>
    <dbReference type="EnsemblBacteria" id="ABF88253">
        <property type="protein sequence ID" value="ABF88253"/>
        <property type="gene ID" value="MXAN_3714"/>
    </dbReference>
    <dbReference type="GeneID" id="41361047"/>
    <dbReference type="KEGG" id="mxa:MXAN_3714"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_3_7"/>
    <dbReference type="OMA" id="SICLHAW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25498" checksum="62123566ABFECC0D" modified="2006-07-11" version="1">MTDVRILFEGGGVLVVDKPPGMLVIPGREGGPSLRELLETQRRQKIFVVHRLDRDTSGALVFALDAAVHRALSGAFETGKVRKRYVALVEGRVEAPQMVDAPLVAGRKGRMRVARPGDTDAKASRTRVRPVETFERASLVEAEPLTGRTHQIRVHLLSLGHPLLVDHQYGREAPLTEKDLGGEGDSVVLSRTPLHAARVEWPALAGVEARAVEAPVPEDMARARELLRASVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6F3</accession>
    <name>Q1D6F3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553606.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3580"/>
    <dbReference type="EnsemblBacteria" id="ABF86361">
        <property type="protein sequence ID" value="ABF86361"/>
        <property type="gene ID" value="MXAN_3580"/>
    </dbReference>
    <dbReference type="GeneID" id="41360926"/>
    <dbReference type="KEGG" id="mxa:MXAN_3580"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034130_0_0_7"/>
    <dbReference type="OMA" id="VERCTHT"/>
    <dbReference type="OrthoDB" id="966615at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="368" mass="38878" checksum="14D142C17196F607" modified="2006-07-11" version="1">MPGLPCRPTALNLHPMLLGHMKAPHWPASEEALANARDFLMTLKDRHVVVAPHPSVDGLAAGALMLRALQAMGARVKAQVPAKGEHALSPTFQQRLRAAQPDAWVVLEMSSDAMDDSVAPPGLPTLIVAPQAAPAGKAGTTVLSARGLEPAVSCSLLTYALVSPCVVPGPLEWLAVLGTVADQGVDAPIPFLKDALRRAGRTAVTESVALLNAARKSSRYAAPLALGVLLRAGSATDITRGNVPGVDTLHDCRLEVQREVLRCSKTPPRIASPVALLLFSSEAQVHPQVAVRWAQRLPEHIIIAANAGYLPGRVDFAVRSRTPMELGGLPFNATGGSLSREDFLRFAAGLGFKGLRDIDVERRGAFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D742</accession>
    <name>Q1D742_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3332"/>
    <dbReference type="EnsemblBacteria" id="ABF89904">
        <property type="protein sequence ID" value="ABF89904"/>
        <property type="gene ID" value="MXAN_3332"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3332"/>
    <dbReference type="HOGENOM" id="CLU_707546_0_0_7"/>
    <dbReference type="OMA" id="FLHELCT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="391" mass="43632" checksum="4A86431AF58857E5" modified="2006-07-11" version="1">MMEVYLLATEQEGPAPLDALRTSFANDEVEFTPDADGEGFTLRADGSEVLVRLTRGSEGLPRFRKEVFSGSPDAFERLGRAKAYYHLSVEPGGAQPTLPVFEALWAVRTLLEHVQGVLVDLTAFKLHEPDDVAEITELDFDIRDHVHLHAVEATEGDTPLWVHSHGMEKFGARDLEIFHLAEKDLLAAESFLHELCTDLAFGQGPALRTQVGTSEGQVFTLVPSEEARANLLGVPLDTFEGHEGLFLTVVSPLGRHNTSQLLEPYRERFEKEPEEQTQAMRREAQLVLPSFLARFQRKGLMEPLTFLVRAPFDTHPEGNTVTENLWLEVMGRDEGSVVGKLVDGAVHTTEWRKGAHVEVAETQVNALAISREGRALDERELRELLNAERPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D743</accession>
    <name>Q1D743_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553366.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3331"/>
    <dbReference type="EnsemblBacteria" id="ABF92506">
        <property type="protein sequence ID" value="ABF92506"/>
        <property type="gene ID" value="MXAN_3331"/>
    </dbReference>
    <dbReference type="GeneID" id="41360684"/>
    <dbReference type="KEGG" id="mxa:MXAN_3331"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_7"/>
    <dbReference type="OMA" id="LMIYLRC"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="24535" checksum="54676FB4D0C827DD" modified="2006-07-11" version="1">MARKKFIAIAGNIGAGKTELTSFLCRKYGLTPSFEPNDQNPYLADFYKDMKTWAFRSQLFFLTHKFRLHRELERTSGTVLQDRTLYEDAEIFAKNLHRQRLIDKRDWKTYCELYETISESLRPPDLMIYLRCPVQTIRERIRIRGRAMERDIPTRYLQRLNALYEEWFEGYRLSPVLVLPTDKLDYLTNLVDRVDLFRQIEKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D790</accession>
    <name>Q1D790_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553329.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3284"/>
    <dbReference type="ESTHER" id="myxxd-q1d790">
        <property type="family name" value="Atu1826-like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87104">
        <property type="protein sequence ID" value="ABF87104"/>
        <property type="gene ID" value="MXAN_3284"/>
    </dbReference>
    <dbReference type="GeneID" id="41360637"/>
    <dbReference type="KEGG" id="mxa:MXAN_3284"/>
    <dbReference type="eggNOG" id="COG2945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303184_0_0_7"/>
    <dbReference type="OMA" id="MEGTAHR"/>
    <dbReference type="OrthoDB" id="1090356at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="21716" checksum="E6B8F15A5D3DC824" modified="2006-07-11" version="1">MVQKGQFLERATLVPVGSEVMEGTTHRGSRAPPLLVIPPRPDEGGGMDHVIAAELVWAAANAGFPTLRFNHRGVGASQGKRGRDLELLADAEAAMQMLLENAGANALAVASLHGGAQVALALQAKHPAVGGLCLVAPALVAPEVLSRVTCPLLVVQGEEDTRLPRAAVSAAIARTGGDLEVIDDAGPTFQRNLPQVGRAVAAWLRRLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D798</accession>
    <name>Q1D798_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553321.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3276"/>
    <dbReference type="EnsemblBacteria" id="ABF88632">
        <property type="protein sequence ID" value="ABF88632"/>
        <property type="gene ID" value="MXAN_3276"/>
    </dbReference>
    <dbReference type="GeneID" id="41360628"/>
    <dbReference type="KEGG" id="mxa:MXAN_3276"/>
    <dbReference type="eggNOG" id="ENOG502Z7KB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701917_0_0_7"/>
    <dbReference type="OMA" id="HLAMEGF"/>
    <dbReference type="OrthoDB" id="471493at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="43636" checksum="98AAC5940F5854EE" modified="2006-07-11" version="1">MTDARLIQRLEPAGLRLAPSQVWGGIRLVPVLRDEVRGDLRMSLRTYDDVAAVVSVKGGLKEPGLKYISYVPHGLVMTWGNRQAEAVYGTQLQPEDGKRLKAGPFSIRLLHRMVHREDRRQLRMLPLHLAMEGFLSLQFGGPEIAWAEYSREGLSRGLAPRSEGSVPGWASPMLDGALRTFEIHPQQVGLLLFNADVLLSAFVVAHPDDYRALHRTLVEDFYGDLLLQYGFLGDAPELGLTLDDARVSSLEDLRNEVHRMRQDWADFHGFMAGSLFGASMSSTGVYKAGGFLLQRFHTSLDPAEENHIGEAIVGTDGTLEYLKTYRLSAAQTRRAYLLSQLAQCDWHLEDTAERLRTTVSDLSLRLRNAGFGYLLKDSVLEAVQRKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7R2</accession>
    <name>Q1D7R2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain/tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553158.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3108"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86311">
        <property type="protein sequence ID" value="ABF86311"/>
        <property type="gene ID" value="MXAN_3108"/>
    </dbReference>
    <dbReference type="GeneID" id="41360469"/>
    <dbReference type="KEGG" id="mxa:MXAN_3108"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375893_0_0_7"/>
    <dbReference type="OMA" id="LSECRSY"/>
    <dbReference type="OrthoDB" id="236408at2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
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        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="743" mass="80653" checksum="5EC84E6F34BF0F9D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8C3</accession>
    <name>Q1D8C3_MYXXD</name>
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        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2889"/>
    <dbReference type="EnsemblBacteria" id="ABF85903">
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        <property type="gene ID" value="MXAN_2889"/>
    </dbReference>
    <dbReference type="GeneID" id="41360258"/>
    <dbReference type="KEGG" id="mxa:MXAN_2889"/>
    <dbReference type="eggNOG" id="COG2100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071824_0_0_7"/>
    <dbReference type="OMA" id="CHIGYVH"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF85903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="33200" checksum="937A6247B88389E2" modified="2006-07-11" version="1">MKLTVLYRGPLSSCNYGCEYCPFGKWKHTDEELAKDRADLERFVAWVEARTQDTVSVFFTPWGEALIWPWYQEALARLSHLPHVERLAIQTNLSCKLDWVAGVRADKLGIWATYHPEWTKRHRFVAQCAKLTELGVRHSVGVVGFLRFTEEAEALRAELPADTYLWINAVKDGQEEPYTAEDVARFTRLDPLFPVNNTRHPSLGRACRGGESVISVDGEGTARRCHFIEEAIGNIYAPDFDSALRPRPCAKQTCGCHIGYVHLEYLELDRVFGSGILERVPATPLWKAGLGGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D916</accession>
    <name>Q1D916_MYXXD</name>
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        <recommendedName>
            <fullName evidence="1">DUF4091 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_2638</name>
    </gene>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="EHRVSAH"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="561" mass="61440" checksum="BE80B58F9B788953" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9A0</accession>
    <name>Q1D9A0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="34733" checksum="602264C625679AAB" modified="2006-07-11" version="1">MPAMKPLEGRVALVAGATRGAGRGIATMLGEAGATVYCTGRSVRGRPATGSRPETIEETAEIVDAKGGRGIAVRVDHSVESEVEALCARIQREQGRLDILVNDIWGGDGLTEFGPAFWKQSAAKGQQMFERAVFTHLLTSRHAVPLMLGGERGLIVEITDGDSFGYRGNLWYDLVKMSVIRLAFGMSWELRRTKVTALALTPGFLRSEEMLENFGVTEANWREGAAKDPHFIASESPCYVGRAVAALAADPNVGAKAGRVFSSWALAREYGFTDADGSQPHWGDYFARAFGRPYQVADEDAYTSWRDGPMEIASPDWPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9C6</accession>
    <name>Q1D9C6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002639025.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2528"/>
    <dbReference type="EnsemblBacteria" id="ABF92073">
        <property type="protein sequence ID" value="ABF92073"/>
        <property type="gene ID" value="MXAN_2528"/>
    </dbReference>
    <dbReference type="GeneID" id="41359905"/>
    <dbReference type="KEGG" id="mxa:MXAN_2528"/>
    <dbReference type="eggNOG" id="COG3215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136718_0_0_7"/>
    <dbReference type="OMA" id="DEPGMGI"/>
    <dbReference type="OrthoDB" id="1538398at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="14866" checksum="780912C431078D90" modified="2006-07-11" version="1">MSEQKTGPEHRQNGRAPIELKVDYKKLNSFFADYTKNISKGGTFIKTKKPLPIGTRFLFKLTVPHREAPFELLGEVVWSKADADEPGMGIRFIYSSEAQRVEFETVVEGLMSDSLGGELTEKLLNKPLHSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E0</accession>
    <name>Q1D9E0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General secretion pathway protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gspD</name>
        <name evidence="10" type="ORF">MXAN_2514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family. GSP D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552585.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2514"/>
    <dbReference type="EnsemblBacteria" id="ABF86495">
        <property type="protein sequence ID" value="ABF86495"/>
        <property type="gene ID" value="MXAN_2514"/>
    </dbReference>
    <dbReference type="GeneID" id="41359891"/>
    <dbReference type="KEGG" id="mxa:MXAN_2514"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006756_1_0_7"/>
    <dbReference type="OMA" id="YAVVEMD"/>
    <dbReference type="OrthoDB" id="881521at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013356">
        <property type="entry name" value="T2SS_GspD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02517">
        <property type="entry name" value="type_II_gspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188288" evidence="8">
        <location>
            <begin position="22"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="9">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="9">
        <location>
            <begin position="341"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="750"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="863" mass="91844" checksum="74848007477F6693" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9F1</accession>
    <name>Q1D9F1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552574.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2503"/>
    <dbReference type="EnsemblBacteria" id="ABF88983">
        <property type="protein sequence ID" value="ABF88983"/>
        <property type="gene ID" value="MXAN_2503"/>
    </dbReference>
    <dbReference type="GeneID" id="41359881"/>
    <dbReference type="KEGG" id="mxa:MXAN_2503"/>
    <dbReference type="eggNOG" id="COG3149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1458430_0_0_7"/>
    <dbReference type="OMA" id="QTWFERL"/>
    <dbReference type="OrthoDB" id="1478914at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007690">
        <property type="entry name" value="T2SS_GspM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04612">
        <property type="entry name" value="T2SSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20582" checksum="4FCB2B8D20FD8DE3" modified="2006-07-11" version="1">MAKLQEVFAPVQTWFERLSDRERRMVSIAGAAVLVFVLFAVVMTFTNSASGYRKRTEEKLTKLQEVNTLAASFREAQANRQSVEQQLRSSNVQLISYIEDKATLAGLQVPNMTPKGEVGIGDGKIVESAVELTFTDVDLRKLTDFLQTVESGPGVVKVKLLRIEPRPASDTLTAWTTVATYRMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9N7</accession>
    <name>Q1D9N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552491.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2416"/>
    <dbReference type="EnsemblBacteria" id="ABF92230">
        <property type="protein sequence ID" value="ABF92230"/>
        <property type="gene ID" value="MXAN_2416"/>
    </dbReference>
    <dbReference type="GeneID" id="41359800"/>
    <dbReference type="KEGG" id="mxa:MXAN_2416"/>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_0_0_7"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="OrthoDB" id="1637132at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="25976" checksum="EEB2A29E436B6F17" modified="2006-07-11" version="1">MVLPVRFVLMRPRNAENLGAAARALKNCGLSDWVWVRPEVEDLEPARRLAVHAGDVLDAARRADTLEEAVADCVWVVGTSSRKVEGKRRLPPRAVGEELVARAPQGPVALVFGDERSGLTNAEVERVHDLSAVPTAPEQPSINLAQAVLLYAYEVRVAMLEAAATPPGPLPAAATDAELAQVESTLESVLTTGGFLVDAQPGRTAVRDLFAPLRRSRLTRKEARLWLAALHSLRKRQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V1</accession>
    <name>Q1D9V1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="10" type="ORF">MXAN_2352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552427.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2352"/>
    <dbReference type="EnsemblBacteria" id="ABF86649">
        <property type="protein sequence ID" value="ABF86649"/>
        <property type="gene ID" value="MXAN_2352"/>
    </dbReference>
    <dbReference type="GeneID" id="41359736"/>
    <dbReference type="KEGG" id="mxa:MXAN_2352"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_2_1_7"/>
    <dbReference type="OMA" id="QIDFHQP"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="6"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="400" mass="44895" checksum="A93308173B0244A8" modified="2006-07-11" version="1">MLDEHDHRALGQRLDLFHLQEEAPGMVFWHPRGLVLYRLLEEHVRQRMRREGYQEVRTPQLYAQPLWERSGHWDNFRENMFLVEDGARHLGVKPVSCPGHIELVQRMAPSYRDLPLRLGEFGLVHRAEPGGALHGLFRLRQFTQDDGHIFCAEPQVVPEVVRFARSLKDFYAGFGFDDVQVAFSGRPASRAGRDELWDKAESWLLLAAKEAGLQCHMQPGEGAFYGPKLEFVLKDRLGRAWQCGTIQLDLVLPERFDLHYVDASGARVRPVMLHRALLGSLERFIGVMLEHHGGALPPWLAPQQVVVASVGEGAADYAERFAAKLQEAGCRASVDRRGESLSRKVLDAHAAGVPWLVVAGAREVAAGNVRLRQRDGAQRDVPWEDAAAELVASCRPAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAD9</accession>
    <name>Q1DAD9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2161"/>
    <dbReference type="EnsemblBacteria" id="ABF88514">
        <property type="protein sequence ID" value="ABF88514"/>
        <property type="gene ID" value="MXAN_2161"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2161"/>
    <dbReference type="HOGENOM" id="CLU_3155201_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="48" mass="5248" checksum="CFC7ED39753356AA" modified="2006-07-11" version="1">MQRRLLTATAWRNSRCFDARANGTRVALANVIQPAPWATSVVAHGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG4</accession>
    <name>Q1DAG4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552214.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2136"/>
    <dbReference type="EnsemblBacteria" id="ABF86353">
        <property type="protein sequence ID" value="ABF86353"/>
        <property type="gene ID" value="MXAN_2136"/>
    </dbReference>
    <dbReference type="GeneID" id="41359535"/>
    <dbReference type="KEGG" id="mxa:MXAN_2136"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_2_7"/>
    <dbReference type="OMA" id="WQGFRTA"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="470" mass="51922" checksum="64F3452223B5DA47" modified="2006-07-11" version="1">MRGFLQSITLVAVFLVGLFTSRPAAAHGSLRERIDTFVRAEQKRQNVPGLAVGVVSHGRVVLAKGYGFANLEHRVPVSKDTLFQSGSLGKQFTAMAVMHQVEAGRISLSDSITKFFPDAPTKWHPITVRHLLTHTSGIQDLEGLLDVRKDYTDEEFAHFIYELPLEFPAGLRWNYSNSGYVLLGIIVNRVAGTDYTNVLGEHVFRPAGMKTARGISEADIIPNRSAGYRVVRGEVKNQEWVSPSLNTTGDGALYFSVKDLLAWDAAVAQRSILSPESWQEILSPVKLNSGATQPYGFGWEILERNGKPLHQHTGGWQGFRTAYSRFIGDSLSIVVLANSSGSNPMTFVEGIAAIVNPALAVPPLTPIPDLEPQVTARLTTLLEQARAGTMEPVEFAYAPWWFWGQAVPFYQQLLQSLAPAGPLVLVKREVVGDDRLYTYLVQFGPKTLRYRVSLIPDGRVSAFRLNEHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI8</accession>
    <name>Q1DAI8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552190.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2108"/>
    <dbReference type="EnsemblBacteria" id="ABF88532">
        <property type="protein sequence ID" value="ABF88532"/>
        <property type="gene ID" value="MXAN_2108"/>
    </dbReference>
    <dbReference type="GeneID" id="41359513"/>
    <dbReference type="KEGG" id="mxa:MXAN_2108"/>
    <dbReference type="eggNOG" id="ENOG502Z9FH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1702359_0_0_7"/>
    <dbReference type="OrthoDB" id="908514at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17510" checksum="76DD0CD00B27A978" modified="2006-07-11" version="1">MTGDERPYGYVSRKQVKQLIGDTLEQDLPVKHVVDELQLTYEPFVLIPDLARRRNCERDWRELLGDRVICLEAPTDTVEVAAGLVGLYEGAFSDLDALAWHLKKQDLSRQRLGAVIRALTPFAATLGRDGIPRPELEDEHLPTNDDNSGYRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAP0</accession>
    <name>Q1DAP0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxynucleoside kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552138.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2054"/>
    <dbReference type="EnsemblBacteria" id="ABF86954">
        <property type="protein sequence ID" value="ABF86954"/>
        <property type="gene ID" value="MXAN_2054"/>
    </dbReference>
    <dbReference type="GeneID" id="41359463"/>
    <dbReference type="KEGG" id="mxa:MXAN_2054"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_0_7"/>
    <dbReference type="OMA" id="EAMVMTP"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="2">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="25048" checksum="A0A5DCA4C0F003B4" modified="2006-07-11" version="1">MDYRYIVVEGPIGVGKTSLSNILAERLAGRRILEVVEENPFLSSFYTDRQKFAFQTQIFFLLSRFRQQQELFQQDLFSSMTVSDYLFAKDRIFAHLNLDAHELALYERVFEALGPRVAKPDLVIYLQARLDVLLHRIKKRGREFERKFDPTYLEGLVHSYNNFFFHYTDTPLLVVDTSDIDFVNVEADREDLLATIRKAKPGTQHYVPKASRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAS8</accession>
    <name>Q1DAS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl endopeptidase Pep</fullName>
            <ecNumber evidence="5">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pep</name>
        <name evidence="5" type="ORF">MXAN_2016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552100.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DAS8"/>
    <dbReference type="STRING" id="246197.MXAN_2016"/>
    <dbReference type="MEROPS" id="S09.076"/>
    <dbReference type="EnsemblBacteria" id="ABF89794">
        <property type="protein sequence ID" value="ABF89794"/>
        <property type="gene ID" value="MXAN_2016"/>
    </dbReference>
    <dbReference type="GeneID" id="41359426"/>
    <dbReference type="KEGG" id="mxa:MXAN_2016"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_7"/>
    <dbReference type="OMA" id="ACMTQRP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="464"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="689" mass="76848" checksum="474FB9BB957D6DCB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT2</accession>
    <name>Q1DAT2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage recombination protein Bet</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552096.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89718">
        <property type="protein sequence ID" value="ABF89718"/>
        <property type="gene ID" value="MXAN_2010"/>
    </dbReference>
    <dbReference type="GeneID" id="41359420"/>
    <dbReference type="KEGG" id="mxa:MXAN_2010"/>
    <dbReference type="eggNOG" id="COG3723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815919_0_0_7"/>
    <dbReference type="OMA" id="MIEKCAR"/>
    <dbReference type="OrthoDB" id="960894at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010183">
        <property type="entry name" value="Phage_lambda_Bet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bet_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="364" mass="39893" checksum="7429B6206AE59D95" modified="2006-07-11" version="1">MEANPQQKAEGTAAGQGGQHAGWTRERVELVKRTICPRGISEDEFALFIEQCKRSGLDPLLKEAFCVARRQNAGNRERPNWVTKYEFQPSEAGMLARAERFPDFKGIQASAVFAEDDIVVDQGRGEVVHRFNPAKRKGALVGAWSRVVREDKLPVVVWLDFSGYVQQTPLWSKIPTTMIEKCARVAALRKAYPEAFGGLYVREEMPAEDYESHSDEHGSGPYEVLGSKPGPLKASFPPLAPQEPRASQAAAAQLDIDVPLQPKQPRESTLEAVPAANPEPAAPRPKPSAVVVAFGPHKGKTASELSDDELSESIDLANEKLMEQPRARWAKAMRENLLALEAETELRCRVPASKGDGNGAAHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB94</accession>
    <name>Q1DB94_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551935.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1833"/>
    <dbReference type="EnsemblBacteria" id="ABF85873">
        <property type="protein sequence ID" value="ABF85873"/>
        <property type="gene ID" value="MXAN_1833"/>
    </dbReference>
    <dbReference type="GeneID" id="41359250"/>
    <dbReference type="KEGG" id="mxa:MXAN_1833"/>
    <dbReference type="eggNOG" id="ENOG5031DN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2494671_0_0_7"/>
    <dbReference type="OMA" id="WPFEVAI"/>
    <dbReference type="OrthoDB" id="2211136at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9509" checksum="5D9156612D72A358" modified="2006-07-11" version="1">MKVKQLISILAKLDADANVYVMMQQHLPFECVLAGVAVRGDFTAEGMQHNEGPRPGEVTASNDVFLLEGEQLRRGDKAAWKSPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBM4</accession>
    <name>Q1DBM4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminoglycoside-3'-adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63228"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:146260"/>
            <dbReference type="ChEBI" id="CHEBI:146261"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551808.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1698"/>
    <dbReference type="EnsemblBacteria" id="ABF86466">
        <property type="protein sequence ID" value="ABF86466"/>
        <property type="gene ID" value="MXAN_1698"/>
    </dbReference>
    <dbReference type="GeneID" id="41359136"/>
    <dbReference type="KEGG" id="mxa:MXAN_1698"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071584_0_0_7"/>
    <dbReference type="OMA" id="VRPWRYP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024172">
        <property type="entry name" value="AadA/Aad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="DUF4111"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="DUF4111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000819">
        <property type="entry name" value="Streptomycin_3-adenylyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4111" evidence="5">
        <location>
            <begin position="152"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="30121" checksum="1B0C8BB14F730DA9" modified="2006-07-11" version="1">MNASVPTEITHQVSSACSVIGRHLASSLQAIHLFGSAVDGGLKPHSDIDLLVTVSAPLTEAVRHALLKELLSVSTWPMTRESLRPLEVTVVVRDAVVPWRYPPSRELQFGEWLRGEMEAGHVQPAIVDPDLTILLAKARRHSICLLGEPATDLFDPVPRTDLARAFYDTALQWNEPADWRGDERTVVLALARIWFSLSTGGIAPKDVAAQWVIERLPDEHQSIMRSARASYLGETQDDLARRGPEVAAFVHCARTAIERMYLEWQSGNPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX7</accession>
    <name>Q1DBX7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding monooxygenase, PheA/TfdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551705.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1594"/>
    <dbReference type="EnsemblBacteria" id="ABF88676">
        <property type="protein sequence ID" value="ABF88676"/>
        <property type="gene ID" value="MXAN_1594"/>
    </dbReference>
    <dbReference type="GeneID" id="41359039"/>
    <dbReference type="KEGG" id="mxa:MXAN_1594"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_2_7"/>
    <dbReference type="OMA" id="AHAMPPW"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="525" mass="56735" checksum="716385DE81D132B4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC67</accession>
    <name>Q1DC67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, GMC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1504"/>
    <dbReference type="EnsemblBacteria" id="ABF86668">
        <property type="protein sequence ID" value="ABF86668"/>
        <property type="gene ID" value="MXAN_1504"/>
    </dbReference>
    <dbReference type="GeneID" id="41358950"/>
    <dbReference type="KEGG" id="mxa:MXAN_1504"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_002483_1_0_7"/>
    <dbReference type="OMA" id="NGPNSCG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="486"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="781" mass="84584" checksum="DF9C7F7D0901D660" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD05</accession>
    <name>Q1DD05_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Virulence-associated protein E domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
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        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="870" mass="96311" checksum="82A3D9EE68DF8A6E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Competence protein F, truncated</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="115" mass="12228" checksum="82E1D6FBE3C917F6" modified="2006-07-11" version="1">MVALPLHTRRYHARKYDQAQLLAGALAKATGRKAPVGLLTRHRETQRQVGLSEAERANNVAGAFAASSRVSGQRVLLVDDVFTTGATARAAASALLEAGSVQVEMLTLARAFSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDA4</accession>
    <name>Q1DDA4_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="171" mass="19017" checksum="2EAF043FAAD1A9D9" modified="2006-07-11" version="1">MEMLCTLRSATEAQRVALLQAPEQLEDFVDDDEDFGDPKGSAFLELDIGEAWHGLQYLLTGTPWEGSPPLDFLVRGGEDVGDIPSEEGTARVFTPAQVQALATALQQVTQKTLRARYDASVMQAQDIYPGTWDEPESEVDLLEELLSYFEELQKFMAAVAKRREALLVHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDQ0</accession>
    <name>Q1DDQ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551083.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0962"/>
    <dbReference type="EnsemblBacteria" id="ABF90955">
        <property type="protein sequence ID" value="ABF90955"/>
        <property type="gene ID" value="MXAN_0962"/>
    </dbReference>
    <dbReference type="GeneID" id="41358421"/>
    <dbReference type="KEGG" id="mxa:MXAN_0962"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279104_0_0_7"/>
    <dbReference type="OMA" id="TDKCECP"/>
    <dbReference type="OrthoDB" id="19388at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188424" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1130" mass="117035" checksum="D5CF4DBA64549741" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDR3</accession>
    <name>Q1DDR3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0949"/>
    <dbReference type="EnsemblBacteria" id="ABF89057">
        <property type="protein sequence ID" value="ABF89057"/>
        <property type="gene ID" value="MXAN_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0949"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_7"/>
    <dbReference type="OMA" id="HAWSNLF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="45"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="466"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="555" mass="61496" checksum="DDF0E640486493ED" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW7</accession>
    <name>Q1DDW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene desaturase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crtI</name>
        <name evidence="6" type="ORF">MXAN_0895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="6"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0895"/>
    <dbReference type="EnsemblBacteria" id="ABF90965">
        <property type="protein sequence ID" value="ABF90965"/>
        <property type="gene ID" value="MXAN_0895"/>
    </dbReference>
    <dbReference type="GeneID" id="41358354"/>
    <dbReference type="KEGG" id="mxa:MXAN_0895"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_7"/>
    <dbReference type="OMA" id="NTCMISI"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
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        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="517" mass="57771" checksum="115BEBBC53097647" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY8</accession>
    <name>Q1DDY8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550995.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0874"/>
    <dbReference type="EnsemblBacteria" id="ABF92451">
        <property type="protein sequence ID" value="ABF92451"/>
        <property type="gene ID" value="MXAN_0874"/>
    </dbReference>
    <dbReference type="GeneID" id="41358333"/>
    <dbReference type="KEGG" id="mxa:MXAN_0874"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070658_0_0_7"/>
    <dbReference type="OMA" id="CPMNIEA"/>
    <dbReference type="OrthoDB" id="1512459at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="23748" checksum="325395F73D2AA2B6" modified="2006-07-11" version="1">MPQLTLVVGSKNYSSWSLRPYLALAHTGQPFQEVVIPLAVPDTEDRIARYSPSKRVPVLQHGDLTIWDSLAICEYLAEAFPQAQLWPQDMAARAVARAVTAEMHSGFGALRQHMNMNLRARSPGKGRAPGVAEDIARVQALWNDCRGRFGQGGPFLFGRFSIADAFYAPVVTRFVTYDVALDAVSAAYRDAVLALPALQKWTEEGRSEPSIPKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE31</accession>
    <name>Q1DE31_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550952.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0829"/>
    <dbReference type="EnsemblBacteria" id="ABF89191">
        <property type="protein sequence ID" value="ABF89191"/>
        <property type="gene ID" value="MXAN_0829"/>
    </dbReference>
    <dbReference type="GeneID" id="41358293"/>
    <dbReference type="KEGG" id="mxa:MXAN_0829"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409834_0_0_7"/>
    <dbReference type="OMA" id="TWSGKAN"/>
    <dbReference type="OrthoDB" id="289553at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188541" evidence="1">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="691" mass="73452" checksum="AE064A8FCD26456D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE92</accession>
    <name>Q1DE92_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_0765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0765"/>
    <dbReference type="EnsemblBacteria" id="ABF89454">
        <property type="protein sequence ID" value="ABF89454"/>
        <property type="gene ID" value="MXAN_0765"/>
    </dbReference>
    <dbReference type="GeneID" id="41358234"/>
    <dbReference type="KEGG" id="mxa:MXAN_0765"/>
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    <dbReference type="OMA" id="WANKGRY"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="27722" checksum="8F7A26587BD366A2" modified="2006-07-11" version="1">MAKSTSQKRPSKAKKPAASKAKAKKAAAPKKAALRTSAAPRRASAPVFEPAVKVPRPPVLEAEPILADEPTPGRPGPKALPSGETAGRVLPFEIDPKRMEEGLRKLQGEMVHWANKGRYTRVRFKFRGKQLLPDLPLAAVVAAEGLTFYWGGILRVLVANVVGGSVFQVELVNDAEKRVQAGKEALLSGDVDQALVLFREAVAMDRDFPSAHLNVGVALKLKGDREGALAAFEKAKKRDPEGPVGAEAERLAAPLRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEG8</accession>
    <name>Q1DEG8_MYXXD</name>
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        <submittedName>
            <fullName evidence="4">Ferric siderophore ABC transporter periplasmic ferric siderophore-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ferric siderophore ABC transporter, periplasmic ferric siderophore-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0687</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0687"/>
    <dbReference type="EnsemblBacteria" id="ABF87547">
        <property type="protein sequence ID" value="ABF87547"/>
        <property type="gene ID" value="MXAN_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0687"/>
    <dbReference type="eggNOG" id="COG4607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_3_1_7"/>
    <dbReference type="OMA" id="KMSAFGP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01140">
        <property type="entry name" value="FatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033870">
        <property type="entry name" value="FatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="40"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLH55574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="32609" checksum="55CD4D3C6E01BA3F" modified="2006-07-11" version="1">MRFQRPDAAASTPAAEAAAPEGRTVTHGQGTTVVPLKPRRVVVFDLVALDILQALEVDVHGVAGDMFPQHLTRFRDAKYPRMGTLFEPDYEALQAAKPDLIITGGRSSAKYSNLSRIAPTIDVPMSGKDFIASVIANTEMLASVFGKEEKARGLIEDLRKSVADLQQMTATRGKGLVVLVTGGRMSAYGPGSRFGVIHGDFGVPEAVEGLRTSLHGESISAEFIREKNPDWLFVIDRDAATGQKEGNARQVLDNELVRQTTAWQKNQVIYLDPGVTYLTGGGIQSVKQLRDQVASAYTQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DET7</accession>
    <name>Q1DET7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550699.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0567"/>
    <dbReference type="EnsemblBacteria" id="ABF92236">
        <property type="protein sequence ID" value="ABF92236"/>
        <property type="gene ID" value="MXAN_0567"/>
    </dbReference>
    <dbReference type="GeneID" id="41358051"/>
    <dbReference type="KEGG" id="mxa:MXAN_0567"/>
    <dbReference type="HOGENOM" id="CLU_2845232_0_0_7"/>
    <dbReference type="OMA" id="MELEHPH"/>
    <dbReference type="OrthoDB" id="2009517at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="63" mass="7141" checksum="A6A137D4240042EB" modified="2006-07-11" version="1">MELEHPHLAVLLLTTEADLRDAREALDGSEESRLRYVAAESRAEAAYFLAWDLLEVDPRMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEU4</accession>
    <name>Q1DEU4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-resistant DD-carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdcA</name>
        <name evidence="4" type="ORF">MXAN_0560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550692.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0560"/>
    <dbReference type="MEROPS" id="M15.002"/>
    <dbReference type="EnsemblBacteria" id="ABF87670">
        <property type="protein sequence ID" value="ABF87670"/>
        <property type="gene ID" value="MXAN_0560"/>
    </dbReference>
    <dbReference type="GeneID" id="41358044"/>
    <dbReference type="KEGG" id="mxa:MXAN_0560"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063658_0_0_7"/>
    <dbReference type="OMA" id="VPSEPWH"/>
    <dbReference type="OrthoDB" id="979360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="VanY" evidence="3">
        <location>
            <begin position="199"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="31181" checksum="7C844BC85B9E67B7" modified="2006-07-11" version="1">MVAIARSSAAASSSASRSASPTLRSGARGAAVTQLQNKLRAAGFNPGASDGVFGPKTQSAVQAFQRARGLQVDGIVGPKTWSALNSAGGAGGSGPTLRNGARGEPVRALQQRLNVLGFKSGTADGVFGPKTQSAVKAFQQSRGLVADGIVGPKTWDKLGINVQGPVTNPGGGGGGRVVTGYVNGKPRQISLSSVPNGKEMRSDAAAAYNRMYAAARAQGITLKVNSGFRSMAEQEALYRAYKNGTGNLAAPPGYSNHQGGIAVDVNTGGTGTSTYRWMANNAKNFGFVRTVPSEPWHWEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEU7</accession>
    <name>Q1DEU7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550689.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0557"/>
    <dbReference type="EnsemblBacteria" id="ABF89392">
        <property type="protein sequence ID" value="ABF89392"/>
        <property type="gene ID" value="MXAN_0557"/>
    </dbReference>
    <dbReference type="GeneID" id="41358041"/>
    <dbReference type="KEGG" id="mxa:MXAN_0557"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802047_0_0_7"/>
    <dbReference type="OMA" id="TIHTLHM"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17099" checksum="09CD976C3A767FAB" modified="2006-07-11" version="1">MNDTSSSSVSSRPVDPERMPWIPMGPAGLSFKPLRFFQDGSGWMYLFRLEPGTVIPRHRHTGEAHGFNLSGTRELLDTGEVIGPGGYVYEPPGNVDSWRVTGDAPAVLLITVRGAIEYLTEDGQVSKRVTSEERLQTYRRWCEANSAPFLATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEU9</accession>
    <name>Q1DEU9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550687.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0555"/>
    <dbReference type="EnsemblBacteria" id="ABF90703">
        <property type="protein sequence ID" value="ABF90703"/>
        <property type="gene ID" value="MXAN_0555"/>
    </dbReference>
    <dbReference type="GeneID" id="41358039"/>
    <dbReference type="KEGG" id="mxa:MXAN_0555"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905241_0_0_7"/>
    <dbReference type="OMA" id="IGGNHEP"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="31062" checksum="9DFD9A47A11C8DE2" modified="2006-07-11" version="1">MFSSQTFFFAVVGDVHGHMHQMVSHLTAWEERSRRPLDFVLQVGDFEPHRHNADLATMAAPTKYRHLGDFAAYHQRRRRFPWPVYFIGGNHEPYGHLDLYPEGFALAPHCHYLGRSGVVELNGLRVAGLSGIHREATFCKSRPPLASMGDVSNKDFTFFNEEDVERVLALGRADVLLLHDWPSGIIPPEEAADFQGQRRGASHDLVGNAYARLLVDALQPRLVLCGHLHRRYAGTVQHPGGQRSLVRCLASVEQGAEAFAVFQCREGTLQEIAMWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEW7</accession>
    <name>Q1DEW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550669.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0537"/>
    <dbReference type="EnsemblBacteria" id="ABF91887">
        <property type="protein sequence ID" value="ABF91887"/>
        <property type="gene ID" value="MXAN_0537"/>
    </dbReference>
    <dbReference type="GeneID" id="41358021"/>
    <dbReference type="KEGG" id="mxa:MXAN_0537"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_1_0_7"/>
    <dbReference type="OMA" id="EYCQRPL"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="486" mass="53815" checksum="3857DCE4A391DC25" modified="2006-07-11" version="1">MHLFDIPAWLEVAWPHVVAALTVLISVVASAHAVLHKRDVRAAVGWVGLAWLVPVLGGVLYVLLGINRIRRRARSLMLKQEHGRFPPLFQVAPMKAETVSGPHPEAAPLAPLVRLGDAVVGRPLLPGNRFTVLESRRDAYPAMLEAIDAARTTLSLCSYIFDNDMAGRRFVEALSAAVKRGVEVRVLVDAVGSRYTWPPILGRLRRAGVRAARFLPSLMPYRLPFANLRNHRKLMVVDGRVGFTGGMNIRKAFWPGEHAAVDLHFRVEGPLVGQLQETFAEDWAFTTRERLTGEAWFPPLTEVGTVLARGIADGPDEDFETLRTVLLGALATARTSVRIVTPYFLPDTALITALSVAALRGVQVDILLPEKGNLPLVQWAAWAQLWQVLRPGCRIFLTAPPFDHTKLMVVDGVWSLIGSANWDPRSLRLNFEFNVECYDTALAMQLEGVVAARLRNARPLTLEQVDARALPIRLRDGLARLLSPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ4</accession>
    <name>Q1DEZ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell wall surface anchor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0510"/>
    <dbReference type="EnsemblBacteria" id="ABF90085">
        <property type="protein sequence ID" value="ABF90085"/>
        <property type="gene ID" value="MXAN_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0510"/>
    <dbReference type="eggNOG" id="COG3204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300124_0_0_7"/>
    <dbReference type="OMA" id="NTNITHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="998" mass="102531" checksum="F22157906D948CE4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF15</accession>
    <name>Q1DF15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550621.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90828">
        <property type="protein sequence ID" value="ABF90828"/>
        <property type="gene ID" value="MXAN_0488"/>
    </dbReference>
    <dbReference type="GeneID" id="41357979"/>
    <dbReference type="KEGG" id="mxa:MXAN_0488"/>
    <dbReference type="eggNOG" id="ENOG503349R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176806_0_0_7"/>
    <dbReference type="OMA" id="WDISESD"/>
    <dbReference type="OrthoDB" id="2044436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="106" mass="12201" checksum="0C40A441823A5C3A" modified="2006-07-11" version="1">MPSIHFKCVDHLNLHRVSDDEYESGNWVVTPADAQRLIGGMLYLHNTKSERSYFGGKIKSARQVRTNDRIPDRIVFRFVPLSEARGVRWRGIDHINAHQSGVVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFF4</accession>
    <name>Q1DFF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550483.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0345"/>
    <dbReference type="EnsemblBacteria" id="ABF91120">
        <property type="protein sequence ID" value="ABF91120"/>
        <property type="gene ID" value="MXAN_0345"/>
    </dbReference>
    <dbReference type="GeneID" id="41357843"/>
    <dbReference type="KEGG" id="mxa:MXAN_0345"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015278_2_0_7"/>
    <dbReference type="OMA" id="TYYMQLV"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14488">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033803">
        <property type="entry name" value="CBM6/CBM35/CBM36-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="312"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="619" mass="66010" checksum="B42887003729DB5B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL7</accession>
    <name>Q1DFL7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB system transport protein ExbB/TolQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550420.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0275"/>
    <dbReference type="TCDB" id="1.A.30.2.3">
        <property type="family name" value="the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92421">
        <property type="protein sequence ID" value="ABF92421"/>
        <property type="gene ID" value="MXAN_0275"/>
    </dbReference>
    <dbReference type="GeneID" id="41357775"/>
    <dbReference type="KEGG" id="mxa:MXAN_0275"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_2_2_7"/>
    <dbReference type="OMA" id="DIYNHMG"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MotA_ExbB" evidence="7">
        <location>
            <begin position="105"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="26512" checksum="676D07F3DE7B85CA" modified="2006-07-11" version="1">MNFNLRDIYNHMGVFALGIAWTLILFAVASLAVFFERLFVFFRSRSISKQFASRAGPLLTQHQHEALVKEAEATKGSHLAMLLGGGMKHFLAKSRVPAGKLGPVELTRRELVRINERVSADVRRGMSVLATVGSVAPFVGLLGTVVGIIEAFSGIAKEGSGGLGAVSAGIAEALVVTALGLLVAIPAVLMFNFLSTRADSLQLSLDAARSEFMDYLEDLGPQKPVATNGAAVATGPELAARKESRDVHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS0</accession>
    <name>Q1DFS0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0221"/>
    <dbReference type="EnsemblBacteria" id="ABF86273">
        <property type="protein sequence ID" value="ABF86273"/>
        <property type="gene ID" value="MXAN_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0221"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049494_1_0_7"/>
    <dbReference type="OMA" id="MNGRWIS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="35684" checksum="4E75A94B0F438214" modified="2006-07-11" version="1">MPMRLRPSLYLASTLLLGIATGCGEDIASHEEALGAVEAAAVSTSGATTHFRNWLSSNGYDSYDFIRTDLTGGSYGGKASASDTVTKQPVIFIHGNSDKAVGSVFGQTGWTNSLEYFHSRGYKTSELYATTWGPANALQSANQYHSKQNVMKVRKFIEAVKAYTGASKVDIIAHSMGVTLARKAILGGTAHDAADGGTYNVGVPLTSSVDTFVGIAGANLGLTSCYMSGPSTPTCGSTNGLYPGYLFWGSVTGRSTYLNDLRSTSGYEGAFRYTIYSTADEIIGYDGIVYGEYTSRIPGQTGEKRYTGYPYGHFNSKDLTAEVQYDMVVNHTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG11</accession>
    <name>Q1DG11_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550276.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0129"/>
    <dbReference type="EnsemblBacteria" id="ABF87432">
        <property type="protein sequence ID" value="ABF87432"/>
        <property type="gene ID" value="MXAN_0129"/>
    </dbReference>
    <dbReference type="GeneID" id="41357633"/>
    <dbReference type="KEGG" id="mxa:MXAN_0129"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972622_0_0_7"/>
    <dbReference type="OMA" id="SLAACIW"/>
    <dbReference type="OrthoDB" id="1670971at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188692" evidence="3">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="31010" checksum="2514A1EDE6270ED0" modified="2006-07-11" version="1">MLVAMTWRRCLSLAACIWIVIPVHAARADGDFERHVAEAVRLYDDLEYERALEQLDRARGSLRGSRDRVTLALHRGIISADLGRWQAARDEFRSALLLEPEARLPLRVSPKVGREFEAQRALAKAELARRRRDSPTREAARIEQAEVETESVADASSALPAALTPTEQATASSPVEVQAWTATSSASWRRIGGRQVPLASLVLLGAGIAATGTGTVFGVSSRGQLADAREARFHEHLVEHRGRAQRSARTANVLFGTAGVAAAGALVTWLLLGERDEAVTQQGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG22</accession>
    <name>Q1DG22_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550265.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0118"/>
    <dbReference type="EnsemblBacteria" id="ABF88992">
        <property type="protein sequence ID" value="ABF88992"/>
        <property type="gene ID" value="MXAN_0118"/>
    </dbReference>
    <dbReference type="GeneID" id="41357623"/>
    <dbReference type="KEGG" id="mxa:MXAN_0118"/>
    <dbReference type="eggNOG" id="ENOG5033CR9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091669_0_0_7"/>
    <dbReference type="OMA" id="PWIFREG"/>
    <dbReference type="OrthoDB" id="875718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="21255" checksum="BA7771A67E3B5599" modified="2006-07-11" version="1">MMAKKYFQLADNVSIPGRWELGHPGDARGHEVDDPWMFREGHPVEVSQRFTVPIEEPGKALDFSLAGFSTPVVSASVANIFLEMAPKDVQLLPVDIHGPLDPYFILVATRLIRCIDDAASEEVLHWRPEDGRPEKVGQYRDVYGMRVDLAQVGNAQVFRTWGWSIALIVSEDIKQALERAKATGVKFTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG84</accession>
    <name>Q1DG84_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">ppk</name>
        <name evidence="10" type="ORF">MXAN_0056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550205.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0056"/>
    <dbReference type="EnsemblBacteria" id="ABF87163">
        <property type="protein sequence ID" value="ABF87163"/>
        <property type="gene ID" value="MXAN_0056"/>
    </dbReference>
    <dbReference type="GeneID" id="41357565"/>
    <dbReference type="KEGG" id="mxa:MXAN_0056"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_4_2_7"/>
    <dbReference type="OMA" id="FMIRVAR"/>
    <dbReference type="OrthoDB" id="76567at2"/>
    <dbReference type="BRENDA" id="2.7.4.1">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="43411" checksum="7511C1389E3B6EFD" modified="2006-07-11" version="1">MRTLRLPRLSSLRAFDHPGYFAVWVGALISTIGTWMETVAMGVYVTEATGRAEWTGGIVALTFLPAVVLSPVGGALADRFDRRAYVALGTVVQLVLAGVLTLLAFTHRLSVPVVAVISFVHGCASTLINPAFAAMLAELVPPRDLHSAMSLNSAQFNLGRIIGPALAALVLSMGGTSWALLINTLSFVAVLVALSQVKTLTRKVTEGGQGLWKQIAHGFTVARGDPEISLMLWGTFLVAGLVAPFIGLVPVFAIRVFGQGAAATSLLVTCQGAGAVTAALLVGTLVDRWGQRKLLGIVATSIGVVSTLYWLSPTLQMAAVVIFVLGANYMMLMSGMHAYCQSRVPRELQARMSSLYSMVLGGAYASGVWGLGALADRLGIRFVTVSASVLFIALVLTLRLLRPQRFDGAVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-12-15" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P95331</accession>
    <accession>Q1CYG0</accession>
    <name>FUMC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fumarate hydratase class II</fullName>
            <shortName evidence="1">Fumarase C</shortName>
            <ecNumber evidence="1">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fumC</name>
        <name type="synonym">fhy</name>
        <name type="ordered locus">MXAN_6439</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-07" db="EMBL/GenBank/DDBJ databases">
            <title>Myxococcus xanthus fumarate hydratase, major proteosome subunit, and acyl-CoA oxidase genes.</title>
            <authorList>
                <person name="Salmi D."/>
                <person name="Creighton C."/>
                <person name="Youderian P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AF013216">
        <property type="protein sequence ID" value="AAB97818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556371.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P95331"/>
    <dbReference type="SMR" id="P95331"/>
    <dbReference type="STRING" id="246197.MXAN_6439"/>
    <dbReference type="PRIDE" id="P95331"/>
    <dbReference type="EnsemblBacteria" id="ABF86177">
        <property type="protein sequence ID" value="ABF86177"/>
        <property type="gene ID" value="MXAN_6439"/>
    </dbReference>
    <dbReference type="GeneID" id="41363648"/>
    <dbReference type="KEGG" id="mxa:MXAN_6439"/>
    <dbReference type="eggNOG" id="COG0114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_7"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000161290" description="Fumarate hydratase class II">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in site B" evidence="1">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="326"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="466" mass="49913" checksum="9496DDD6C1690C55" modified="1998-06-01" version="2">MSTKNVRTEKDTFGPIDVPADRLWGAQTQRSLQNFAISTERMPLALIRALVLVKKAAARVNVENGSLAKEKGEAIIRAADEVLAGQHDAEFPLSVWQTGSGTQTNMNTNEVLANRASELLGGERGERRKVHPNDDVNKGQSSNDVFPTAMSVAAVAAITEHVLPELKALRDVLAQKARAFHDVVKVGRTHLQDATPLTLGQEVGGFVAQLDHAKGHLERTLPHLLELALGGTAVGTGLNAPKGYAERVAQELAQLTGHPFVTAPNKFEALAANDALVQAHGALKGLAAVLFKVANDVRWLSSGPRSGLAEITIPENEPGSSIMPGKVNPTQSEALTMLCAQVMGNDVAVTVGGASGNFQLNVFKPLIAHNLLQSCRLLADGMRSFRLHCAVGIEPNRPRIQENLERSLMLVTALNPHIGYDNAAKIAKTAHRDGTTLKETAVALGLVTPEQFDQWVRPEDMTGHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVG2</accession>
    <name>Q1CVG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7508"/>
    <dbReference type="EnsemblBacteria" id="ABF92281">
        <property type="protein sequence ID" value="ABF92281"/>
        <property type="gene ID" value="MXAN_7508"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7508"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072930_0_0_7"/>
    <dbReference type="OMA" id="MGFPARL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="29599" checksum="C9D270B1AFF85818" modified="2006-07-11" version="1">MAGPEQAPDGRWDAGGGRCGRQTQVSEQVPQQTPSTPASGDSAGEFRGRVEKLLGDILGLMGFPARLDMKDAADGSLSVALHFEPAPPPGVEVGRRSQVVDSLQFLLNKMLHRPGADRRWVMLGAGVHPEPRPRREPQAAAAQAAAPAAPAPAPAAPRAAAAQAPAPAPAKGGQRGAQAPAAKAAPASKGEGDERSVTVEEDAALKAAIRQLAEKSGSLGRFYAIAAMKLEDRARVLTSVEGVGGVKVSAEGEGRNRRVVFTPDKPAPLPKRSMLPDDDEDDFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS3</accession>
    <name>Q1CVS3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sigma-54 factor interaction domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557305.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7393"/>
    <dbReference type="EnsemblBacteria" id="ABF92535">
        <property type="protein sequence ID" value="ABF92535"/>
        <property type="gene ID" value="MXAN_7393"/>
    </dbReference>
    <dbReference type="GeneID" id="41364551"/>
    <dbReference type="KEGG" id="mxa:MXAN_7393"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382822_0_0_7"/>
    <dbReference type="OMA" id="QMQEERP"/>
    <dbReference type="OrthoDB" id="1529519at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14532">
        <property type="entry name" value="Sigma54_activ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="41"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="21462" checksum="0E9124A3AE3E25D1" modified="2006-07-11" version="1">MTPQGYREVELVCNRSSLLLHGGTEEERRCWAQEAARNFNVELVEVRQAAELPQALRQPNGVVFIPDVAKLGRDAQFVLLQCLRTQEERPKLVLGVSGSADAALARGTLREDLHYRLHKAQVDLQKDGLRDVLKSRWAQQAEQLALKAAAARAAEEAAREAAIARRPGTVTRIAPKQKKVSGGARAKAVSRNAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW51</accession>
    <name>CAS2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cas2</name>
        <name type="ordered locus">MXAN_7259</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="J. Bacteriol." volume="189" first="3738" last="3750">
            <title>Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.</title>
            <authorList>
                <person name="Viswanathan P."/>
                <person name="Murphy K."/>
                <person name="Julien B."/>
                <person name="Garza A.G."/>
                <person name="Kroos L."/>
            </authorList>
            <dbReference type="PubMed" id="17369305"/>
            <dbReference type="DOI" id="10.1128/JB.00187-07"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>OPERON STRUCTURE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="developmental stage">
        <text>Operon expression begins by 6 hours after starvation has initiated development and is under strong negative regulation by DevS.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557178.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CW51"/>
    <dbReference type="SMR" id="Q1CW51"/>
    <dbReference type="STRING" id="246197.MXAN_7259"/>
    <dbReference type="EnsemblBacteria" id="ABF89361">
        <property type="protein sequence ID" value="ABF89361"/>
        <property type="gene ID" value="MXAN_7259"/>
    </dbReference>
    <dbReference type="GeneID" id="41364425"/>
    <dbReference type="KEGG" id="mxa:MXAN_7259"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_0_7"/>
    <dbReference type="OMA" id="TYDIEND"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000418220" description="CRISPR-associated endoribonuclease Cas2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17369305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="97" mass="11589" checksum="B514E9C92BC297AA" modified="2006-07-11" version="1">MAEPRRWYLITYDIRDPKRWRKVHALLKGYGEWLQLSVFRCSLTDRDREKLRWELSRRMDAVDTLLVIGLCGGCVERVRAINAKEDWPEEPAPFKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF1</accession>
    <name>Q1CWF1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bacterial lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7159"/>
    <dbReference type="EnsemblBacteria" id="ABF87288">
        <property type="protein sequence ID" value="ABF87288"/>
        <property type="gene ID" value="MXAN_7159"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7159"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_0_7"/>
    <dbReference type="OMA" id="VFGDMCD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="38930" checksum="13A9F6A8BABA69B2" modified="2006-07-11" version="1">MALPSSPLRGGVRHVSQIAPASPPPDSPAVTQKLPSEHLRRIVGTPPGRVVGFLTRFVWAFLTWLSPESRDALARFVGNLAYRLGIRRRVALENLAMAMPEKSDAERREIARGAYINMSRVVLESLPSGDRLPLDWAEQGVEGDAAWQALKARVATGKGALLVTAHFGNWELLGEMLIRHGVPLDALVRPLKGALNTRIAENRVRIGAGLIYPRGAIQEIIDAVNRGESPFMLLDQALPAKGAAFVPFFGKLASTTPAMAVAAARTDAPVFVVMGVRNGRGGARFRMEVEGPILPPAPGECADPITEHTARVTAALERCIRKYPDQWMWLHRRWKVQPPPEAALPAGTTPPPSASGAPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWN4</accession>
    <name>Q1CWN4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7076"/>
    <dbReference type="EnsemblBacteria" id="ABF90434">
        <property type="protein sequence ID" value="ABF90434"/>
        <property type="gene ID" value="MXAN_7076"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7076"/>
    <dbReference type="HOGENOM" id="CLU_1935773_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="130" mass="14504" checksum="1D23E6E401CCA3F5" modified="2006-07-11" version="1">MAWAVEPVLPLTPRQPHARGGRMSDWKRLQKLNGGDAIWYSEPQLDVKDEVWLYSAGGELRVWSAGTLYKPEPKTLKVSAPVKERFTLFKLLSQLFVDVEVRGEKAVVRRGTLNGAHLISLCDASDVGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWY4</accession>
    <name>Q1CWY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556895.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6974"/>
    <dbReference type="EnsemblBacteria" id="ABF87864">
        <property type="protein sequence ID" value="ABF87864"/>
        <property type="gene ID" value="MXAN_6974"/>
    </dbReference>
    <dbReference type="GeneID" id="41364152"/>
    <dbReference type="KEGG" id="mxa:MXAN_6974"/>
    <dbReference type="HOGENOM" id="CLU_147976_0_0_7"/>
    <dbReference type="OrthoDB" id="1951587at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="15643" checksum="7F53AEB9CD8007AA" modified="2006-07-11" version="1">MPKWLPLMCLCTLPACTLFKKPPRPVHVPAEEASRFEFPVGMPEEGRVIIRRPLAQAVQLAMEDYLPWDLKLPPGDRPGGECLYRRESYDVTAAPYEGGIILVSISLDPDACERKGAPYDMGARYAIDSKTWRILAVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX27</accession>
    <name>Q1CX27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556852.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6932"/>
    <dbReference type="EnsemblBacteria" id="ABF88362">
        <property type="protein sequence ID" value="ABF88362"/>
        <property type="gene ID" value="MXAN_6932"/>
    </dbReference>
    <dbReference type="GeneID" id="41364113"/>
    <dbReference type="KEGG" id="mxa:MXAN_6932"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410400_0_0_7"/>
    <dbReference type="OMA" id="WGHGNDA"/>
    <dbReference type="OrthoDB" id="209597at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="669" mass="71743" checksum="E52E6537DB5BAF3B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYD0</accession>
    <name>Q1CYD0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92923">
        <property type="protein sequence ID" value="ABF92923"/>
        <property type="gene ID" value="MXAN_6471"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6471"/>
    <dbReference type="eggNOG" id="ENOG5032PVR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147976_0_0_7"/>
    <dbReference type="OMA" id="AMNEFLP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="149" mass="15998" checksum="9A01C8FF77C53580" modified="2006-07-11" version="1">MAAMRCCHDGGASLRRALAWGPLLGLCGCSALGIYRFDKPERAPANESVTIPSQIEGGVALTGPMMAALKVAMDDFRPPWVTAEKQEHLEEKCLADWRYIDARVVQANDDLFYVTFSPNLSACGPGLVLLDGGVVYAIDGKGRILAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM8</accession>
    <name>Q1CYM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">3.5.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nagB</name>
        <name evidence="3" type="ORF">MXAN_6371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.99.6" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556303.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6371"/>
    <dbReference type="EnsemblBacteria" id="ABF88959">
        <property type="protein sequence ID" value="ABF88959"/>
        <property type="gene ID" value="MXAN_6371"/>
    </dbReference>
    <dbReference type="GeneID" id="41363584"/>
    <dbReference type="KEGG" id="mxa:MXAN_6371"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_1_1_7"/>
    <dbReference type="OMA" id="FNEPCSS"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="2">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="26399" checksum="01C5F9EB79003AF8" modified="2006-07-11" version="1">MRIRVFDSEREAAATCAQRIARAAAAHPSLVLGLPTGRTPLNVYRELVELFTRGGLDWAQVRTFNLDEFLGVSADDAGSFRAYMERHLFQHVNLSPAHIQFLDGAVEDAEAECARYEARLAEAGGLDLVLLGLGSNGHLAFNEPADGLRARCHRTRLSRQTREANLMLFGDDPSRVPMEALTLGMASILQARQALLLAFGEAKAEAVRGMVEGPVSPRCPASFLQLHPDVEVWLDPAAARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYQ3</accession>
    <name>Q1CYQ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556278.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6346"/>
    <dbReference type="EnsemblBacteria" id="ABF92209">
        <property type="protein sequence ID" value="ABF92209"/>
        <property type="gene ID" value="MXAN_6346"/>
    </dbReference>
    <dbReference type="GeneID" id="41363560"/>
    <dbReference type="KEGG" id="mxa:MXAN_6346"/>
    <dbReference type="HOGENOM" id="CLU_1641900_0_0_7"/>
    <dbReference type="OMA" id="KCTARRA"/>
    <dbReference type="OrthoDB" id="1979238at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187992" evidence="1">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="161" mass="16884" checksum="FED3E216BF509CC9" modified="2006-07-11" version="1">MKVILMNLAATAALATTAVLLVADSGEKGCHQPAQSVTFDVGHNTCGAPGILRVSTPQDTCRLDVEAEERTGLPMTGDVYDGSVDLRQGDNWYLADMNVAIIVDADGGTLPGDAGTGTTVEVNRACEVLREGEVLRLKCTARRADLANEPVSACEAVLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYS7</accession>
    <name>Q1CYS7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6321"/>
    <dbReference type="EnsemblBacteria" id="ABF88578">
        <property type="protein sequence ID" value="ABF88578"/>
        <property type="gene ID" value="MXAN_6321"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6321"/>
    <dbReference type="eggNOG" id="ENOG50339VQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082670_0_0_7"/>
    <dbReference type="OMA" id="DESASHY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021815">
        <property type="entry name" value="DUF3396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11876">
        <property type="entry name" value="DUF3396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="33043" checksum="2301C41EBB9AB522" modified="2006-07-11" version="1">MNARPPRLQPQDRDDTPGVSTGLSASFYLPHAHSAVATAVLQALEVYQRTVGPRALTSYEGEDGEWHLLDSQGWAEVHRGMQEEPWANVHLSDASPEASFRFDYLGRERVDVTSVSGLGEVSAVSFWLPTEYLERHGPRQTRELLMALAAPLPFSSGNAGLAFNGSLDVAANIRQVRRDCLRYPGLDVLRLGMTSLHIGTRVRGPSWLTFLGAPVLSQLGGAAQLRSRINAPSTTVQTMEATSAVVTLGDAPATGDSEHGESLSSYRELARILEPWTLWGEGESILGLTPEAARRWERRFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ12</accession>
    <name>Q1CZ12_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6230"/>
    <dbReference type="EnsemblBacteria" id="ABF92889">
        <property type="protein sequence ID" value="ABF92889"/>
        <property type="gene ID" value="MXAN_6230"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6230"/>
    <dbReference type="eggNOG" id="COG5222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1018733_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="30126" checksum="5082F264425F07AA" modified="2006-07-11" version="1">MSSSPRDLRPAVTRRRGSKAWMPWRQTSRGGGYTLDGALREALLALPTEIMAASGRFIYDNCAALRGANRPFVPLFRNFPESVPHDTRQLYVQRMLGWLFQSPEQPCIHCGAQGTVRALSPCAHLVCERCYDGSDYSACPICHRRLSPSEPFLKPTALEAAERVYALAVNRLTRLSLGTDAARHRPRREAAPLGGCEGSSRGWLPECAQLARRAREPWKGHPGLFRNRRPPHALGAGLPSRRRAQSHGAGPAPGWHGVRPEAGLGRGHRRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ62</accession>
    <name>Q1CZ62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556124.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91575">
        <property type="protein sequence ID" value="ABF91575"/>
        <property type="gene ID" value="MXAN_6180"/>
    </dbReference>
    <dbReference type="GeneID" id="41363409"/>
    <dbReference type="KEGG" id="mxa:MXAN_6180"/>
    <dbReference type="HOGENOM" id="CLU_181339_0_0_7"/>
    <dbReference type="OMA" id="IQGSGPC"/>
    <dbReference type="OrthoDB" id="1979240at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188062" evidence="1">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="94" mass="9832" checksum="E5098A3FEC981E78" modified="2006-07-11" version="1">MKTKLAAVTLVASLLASSAAWAAVTVRYYNRDSRDHSWSVVCSGVKTSVTFGKSQTASVTIQGSGPCSVKTDAGTVVLKGGEDLEIKDGRILVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZI7</accession>
    <name>HTPG_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">MXAN_6051</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556000.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZI7"/>
    <dbReference type="SMR" id="Q1CZI7"/>
    <dbReference type="STRING" id="246197.MXAN_6051"/>
    <dbReference type="EnsemblBacteria" id="ABF89090">
        <property type="protein sequence ID" value="ABF89090"/>
        <property type="gene ID" value="MXAN_6051"/>
    </dbReference>
    <dbReference type="GeneID" id="41363289"/>
    <dbReference type="KEGG" id="mxa:MXAN_6051"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_7"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000258515" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="345"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="557"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="654" mass="73272" checksum="6F64A7ADA83AD31C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZM6</accession>
    <name>Q1CZM6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555961.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6012"/>
    <dbReference type="EnsemblBacteria" id="ABF87169">
        <property type="protein sequence ID" value="ABF87169"/>
        <property type="gene ID" value="MXAN_6012"/>
    </dbReference>
    <dbReference type="GeneID" id="41363251"/>
    <dbReference type="KEGG" id="mxa:MXAN_6012"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_7"/>
    <dbReference type="OMA" id="MGDENIT"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="13139" checksum="9368CEB3FACE2272" modified="2006-07-11" version="1">MSDTPTLLLVDDDSFVRRILKDVIADTGIELRLLEAADGEEGLAVAAREKPAVMFLDLFMPKKSGLEVLGAIKAVSPTTRVLVISSMDAEPVVEQAMAAGAVGFVGKPFHPLEIASAVRQALAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZP4</accession>
    <name>Q1CZP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555943.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5994"/>
    <dbReference type="EnsemblBacteria" id="ABF88286">
        <property type="protein sequence ID" value="ABF88286"/>
        <property type="gene ID" value="MXAN_5994"/>
    </dbReference>
    <dbReference type="GeneID" id="41363233"/>
    <dbReference type="KEGG" id="mxa:MXAN_5994"/>
    <dbReference type="HOGENOM" id="CLU_879481_0_0_7"/>
    <dbReference type="OMA" id="NNDARGK"/>
    <dbReference type="OrthoDB" id="1609737at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="33473" checksum="164B6E1E55C465AE" modified="2006-07-11" version="1">MSSISKSFKKAVKKVKKTAKKAGNTVVDTANKAADTVTDTAGTVTNQVSREAEQLAREVDTLTRDTAKLAEQAYAESLAAGEAAWNEMVELSTRFLTDALSDVAEALAEDVYRKHLALLESMAETGSALLTNPTRRKEVDFLVGQSSQKKKDEDTNKTVSSLSQDESVQRTGNEARSKGLGTLSIGSGGSATFGLGPEGNVGIAFDHPGQTQVRGFFGIGGVAGATKGISMNFQFGAWADMPSKLAGPVLTVSLGAGVGKFCGSAQVVFKMPITEKEWTAFATSGRLDLAGLVMCLGAEVSTFAKDGVSATVGGGYTWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ6</accession>
    <name>Q1CZZ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555841.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5890"/>
    <dbReference type="EnsemblBacteria" id="ABF87829">
        <property type="protein sequence ID" value="ABF87829"/>
        <property type="gene ID" value="MXAN_5890"/>
    </dbReference>
    <dbReference type="GeneID" id="41363129"/>
    <dbReference type="KEGG" id="mxa:MXAN_5890"/>
    <dbReference type="eggNOG" id="COG3189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_7"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="15800" checksum="7FE555EE64E8C4A7" modified="2006-07-11" version="1">MTIRLKRAYEAASRTDGRRFLVERLWPRGVRKTALPLEAWLKDAAPSTELRKWFAHDPERWSEFCRRYTAELAANPAAWQPLLEAARHGTVTLVYSAHDTEHNNAAALQQFLEEASGGAAPKKPPCLPRRGRGRSTRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D017</accession>
    <name>Q1D017_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555820.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5869"/>
    <dbReference type="EnsemblBacteria" id="ABF89390">
        <property type="protein sequence ID" value="ABF89390"/>
        <property type="gene ID" value="MXAN_5869"/>
    </dbReference>
    <dbReference type="GeneID" id="41363108"/>
    <dbReference type="KEGG" id="mxa:MXAN_5869"/>
    <dbReference type="eggNOG" id="COG3317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433111_0_0_7"/>
    <dbReference type="OMA" id="YVLETEW"/>
    <dbReference type="OrthoDB" id="1616480at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="21809" checksum="474C3E0D1A2755CD" modified="2006-07-11" version="1">MLGGARPFSSHLQEPPMHSSTRLAGVCLVVATLLTLTGCSSSMRKNYVRDKAASHVYRQELAQLWPHVQEVLRGHGYSWKEMPGRYVLETEWLDSGGGSLGPGTASRFLVQGIVLTGGGTALRVMRGDRITQSIGVGYVDKEIKTDEDYAQAVHDSQASGVLPTRQNYFRDLEIELEILRRSDPEAAARFDADALAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J3</accession>
    <name>Q1D0J3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555644.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5692"/>
    <dbReference type="EnsemblBacteria" id="ABF86415">
        <property type="protein sequence ID" value="ABF86415"/>
        <property type="gene ID" value="MXAN_5692"/>
    </dbReference>
    <dbReference type="GeneID" id="41362937"/>
    <dbReference type="KEGG" id="mxa:MXAN_5692"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062807_0_0_7"/>
    <dbReference type="OMA" id="LREHRTF"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="34636" checksum="D1D721A316227B9E" modified="2006-07-11" version="1">MTSSISPPESRISFLPPDVPDAASTPALGKTARSPKPVSRVTVGQGPQPSLDARPRSGTPLPLEGVDRPARTPAPPDNARFTGLPQLADVASGAQILGPGSQGEGLRAVQATLLDMGFALHGGADGHHGPHTTRALRNFQVHASRTFPAVLPTGALDASTLRALDALAPAPGTRGQTRGLPSAFFDGQQVRVVVALREHRTFLFDTRGQLVDIFPNATGAAASPTRTGIKVVRTKLDQLATEAAGARLWNDRHVFGVRMLDLSWADGRHSGEELHGTNAPALLGTDVSHGCIRHSNEAVRVLHDALSVGDRVAVVEHVDDPHLGVPRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R7</accession>
    <name>Q1D0R7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555571.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5617"/>
    <dbReference type="EnsemblBacteria" id="ABF88806">
        <property type="protein sequence ID" value="ABF88806"/>
        <property type="gene ID" value="MXAN_5617"/>
    </dbReference>
    <dbReference type="GeneID" id="41362863"/>
    <dbReference type="KEGG" id="mxa:MXAN_5617"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_0_7"/>
    <dbReference type="OMA" id="ENDFFRA"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="117" mass="13064" checksum="0BE899B52151BEDE" modified="2006-07-11" version="1">MHAFDVLGEPVRRRILELLAEGERPSGEVTESIQAEFGISQPAVSQHLKVLRDSGFAEVRAEGTRRLYRVDPAPLQQVDAWLEQFRVFWTPRLEALATEVARGKRARAKADNEGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0U0</accession>
    <name>Q1D0U0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/lipoic acid binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555548.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5594"/>
    <dbReference type="EnsemblBacteria" id="ABF91439">
        <property type="protein sequence ID" value="ABF91439"/>
        <property type="gene ID" value="MXAN_5594"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5594"/>
    <dbReference type="eggNOG" id="COG1038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_9_1_7"/>
    <dbReference type="OMA" id="MAGNLWK"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="70" mass="7465" checksum="83085A652E108776" modified="2006-07-11" version="1">MADVAAHITGTVWKIEVQVGQQVNAGDTLVILESMKMEMPVEAEDGGTVKEIRVKEAQSVNEGDVLVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5585"/>
    <dbReference type="CAZy" id="GT83">
        <property type="family name" value="Glycosyltransferase Family 83"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88444">
        <property type="protein sequence ID" value="ABF88444"/>
        <property type="gene ID" value="MXAN_5585"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5585"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363986_0_0_7"/>
    <dbReference type="OMA" id="FIYFIEQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
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        <location>
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            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="131"/>
        </location>
    </feature>
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            <end position="155"/>
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    </feature>
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            <end position="200"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="555"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
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            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="727" mass="80520" checksum="5342B03846A1793B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V4</accession>
    <name>Q1D0V4_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89528">
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    </dbReference>
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    <dbReference type="OMA" id="VEDAFPK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="66323" checksum="106A64FEEFE64FD9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0X3</accession>
    <name>Q1D0X3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_5561</name>
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    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG50344B2">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="14201" checksum="27727EB7593FF0AE" modified="2006-07-11" version="1">MDRMLFYAHSGLRYLVLLAGILALAYFAYGLATRKPFDKLGRILGSAYSGLLQLQVLLGVGVLVTRFYYPALIGHIVMMVLAAGVAQATLSINRRKPQPAFVLPLVGVVVSIIFIIGGIMAIGRGVFTTTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0X7</accession>
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        <submittedName>
            <fullName evidence="4">Putative iron-sulfur binding oxidoreductase</fullName>
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    </protein>
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        <name evidence="4" type="ORF">MXAN_5557</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92042.1"/>
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    <dbReference type="EnsemblBacteria" id="ABF92042">
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        <property type="gene ID" value="MXAN_5557"/>
    </dbReference>
    <dbReference type="GeneID" id="41362805"/>
    <dbReference type="KEGG" id="mxa:MXAN_5557"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306470_0_0_7"/>
    <dbReference type="OMA" id="EGNDEHP"/>
    <dbReference type="OrthoDB" id="178823at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MoCo_extend_TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="992" mass="106171" checksum="F85F7CF67FEB4B33" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D166</accession>
    <name>Q1D166_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_5464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89302">
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        <property type="gene ID" value="MXAN_5464"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="HTMDYKK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="18593" checksum="121D4FCD42BFF0D9" modified="2006-07-11" version="1">MNLYLRMLWVMLSSLWKPEMRVDALTSTLEQRVLPNDLDLNLHMNNGRFLTVCDLSRVDLFIRTGLLALMLKQKWAPIIVRHTMDYKKPLRPFQKYTVSMSITRWDEKYFYATHQFLSRGKVVAEGESTAVLLGREGVVPPEKVIEAVTARQNRTAVESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1S7</accession>
    <name>Q1D1S7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87025">
        <property type="protein sequence ID" value="ABF87025"/>
        <property type="gene ID" value="MXAN_5244"/>
    </dbReference>
    <dbReference type="GeneID" id="41362523"/>
    <dbReference type="KEGG" id="mxa:MXAN_5244"/>
    <dbReference type="eggNOG" id="COG3059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1744031at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007339">
        <property type="entry name" value="RclC-like"/>
    </dbReference>
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        <property type="entry name" value="PTHR40106"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="21920" checksum="0584197FE8CF8DBA" modified="2006-07-11" version="1">MSRIESLLRLAARADRIGMNVLRAGLIVVLVWIGSLKVAEYEADGIVPFVANSPVMSFVYAYDAPEYRQHMNAEGALVPANRAWHEANGTYGFSYLLGGVIVLFGLLIAAHWWRPELGAIGSALVIGMSVVTLSFLVTTPESWVPALGDAHHGFPWLSGRGRLVVKDAIMIGAAIVTMADSARVWLAQRKPQPAEQFHRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X5</accession>
    <name>Q1D1X5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">truD</name>
        <name evidence="6" type="ORF">MXAN_5195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555166.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5195"/>
    <dbReference type="EnsemblBacteria" id="ABF91193">
        <property type="protein sequence ID" value="ABF91193"/>
        <property type="gene ID" value="MXAN_5195"/>
    </dbReference>
    <dbReference type="GeneID" id="41362477"/>
    <dbReference type="KEGG" id="mxa:MXAN_5195"/>
    <dbReference type="eggNOG" id="COG0585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_0_7"/>
    <dbReference type="OMA" id="LWLWVEK"/>
    <dbReference type="OrthoDB" id="1490777at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043165">
        <property type="entry name" value="TruD_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="153"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="37625" checksum="6CA4E4BEBB36BB63" modified="2006-07-11" version="1">MTDSGWPRLTAEVPGCGGAFKLVPEDFEVEEVPAYLPSGEGEHLYLWVEKRGRDTRELVRALAASLGVSEDDIGVAGMKDRHAITRQLVSVPARAEPKVPEFALDGVQVLWTKRHGNKLRTGHLRGNRFRLRLRDVKDSGAARETFSRLVAQGVPNYFGEQRFGRAGDNADLGRLLVLGQRLPKRPDRFQRKLYLSAFQSRLFNQALAARLHAGTLATALAGDVLRKEETGGLFVCESPEVDGPRVASFEVSPAGPLFGPKMTASAGAVAELEARLLAEAGVTPEDFKRGGGETEGSRRPYRVRLGSPELTAEKTADGEDLWLTFELPRGAYATEVLHELLKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X9</accession>
    <name>Q1D1X9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555162.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5191"/>
    <dbReference type="EnsemblBacteria" id="ABF92823">
        <property type="protein sequence ID" value="ABF92823"/>
        <property type="gene ID" value="MXAN_5191"/>
    </dbReference>
    <dbReference type="GeneID" id="41362473"/>
    <dbReference type="KEGG" id="mxa:MXAN_5191"/>
    <dbReference type="eggNOG" id="COG2027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053834_0_0_7"/>
    <dbReference type="OMA" id="AIWINNE"/>
    <dbReference type="OrthoDB" id="1647276at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010846">
        <property type="entry name" value="DUF1460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07313">
        <property type="entry name" value="DUF1460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188033" evidence="1">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="35116" checksum="E4185E36783C08E3" modified="2006-07-11" version="1">MKVVAVLAAALLSQAPAVPTPLEDVDTRPGAEALLESPSASKQLATARPAKPNGWVGLSAEARAALVSEDADAPLAGRLLRMSERFINTPYVLSPLGEGQGVDPDPTFRLDAVDCLTFVEQSMALSLAGSEDEVAPLLERIRYASSPTYEDRNHLMEAQWLPNNIRKGFLTDVTRRYAGDDAVTVTKSLTKVSWQSRSSQALGLPKAQHVVGTYPLNMLPLERVMAHARDIPSGTILVVMREDLPLKVTRITHLGFVVQRKKRTYLRHASRGGYNRVVDEDLETFLARNGRYSKWRVTGVSLFEPRRPDVASGGSVARPVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D225</accession>
    <name>CHEB2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 2</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB2</name>
        <name type="ordered locus">MXAN_5145</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555116.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D225"/>
    <dbReference type="SMR" id="Q1D225"/>
    <dbReference type="STRING" id="246197.MXAN_5145"/>
    <dbReference type="EnsemblBacteria" id="ABF91845">
        <property type="protein sequence ID" value="ABF91845"/>
        <property type="gene ID" value="MXAN_5145"/>
    </dbReference>
    <dbReference type="GeneID" id="41362427"/>
    <dbReference type="KEGG" id="mxa:MXAN_5145"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="QHINAAF"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264293" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 2">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="352" mass="37118" checksum="E83439A9A3CFBE52" modified="2006-07-11" version="1">MGKKVSVLVVDDSLICRQLICEALSKDPDIEVVGTCADGKQAVEMTKELRPHVITMDVDMPVMDGLTATEHIMAECPTPILVLTADPRSQAPELTYRALELGALALQIKPAIDAGPDAWNLVREIRLLSSVRVIRHLRRPQRGPLLPPRVATSVLPAVSMGVVVVAASTGGPQVLFKMLSELPADFPAPIVIVQHINAAFAESLAGWLAGASKLKVRLAQDGEPLMPGHVLIAPPGQHTVIPFRGRVGIKLGVERDGHMPSGTVLLESAARTYGRRAVGLVLTGMGADGADGLLAIKQAGGLAVAQNEESCVVFGMPGAAVERKAVDHLIHGDEVAATLVRLARGESLSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2A3</accession>
    <name>Q1D2A3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87093">
        <property type="protein sequence ID" value="ABF87093"/>
        <property type="gene ID" value="MXAN_5066"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5066"/>
    <dbReference type="HOGENOM" id="CLU_2494673_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9123" checksum="BDA4A130FA98A55A" modified="2006-07-11" version="1">MVSVAGGAPITLERGAASLVGIRVEELMAYGIANHLWIHGSPDRFRVRQWMAAALGTSFGDQPQSDIVVADVFQFGPALTLINISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2B6</accession>
    <name>Q1D2B6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555028.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5052"/>
    <dbReference type="EnsemblBacteria" id="ABF92387">
        <property type="protein sequence ID" value="ABF92387"/>
        <property type="gene ID" value="MXAN_5052"/>
    </dbReference>
    <dbReference type="GeneID" id="41362336"/>
    <dbReference type="KEGG" id="mxa:MXAN_5052"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555239_0_0_7"/>
    <dbReference type="OMA" id="YQVHYAP"/>
    <dbReference type="OrthoDB" id="1143375at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="53958" checksum="0DECF132F4548ABE" modified="2006-07-11" version="1">MAPVRKILIADPDLESVRSLSRALRTKGYQVHYAPDGSRALEVAVLRHPDLTLFDEACRLLDARTFIQILRTNPRTEDIPVVLTTASFESDRLRGLRDGYLRKPFNLDEVLSRIEHIFRRSEAAKDLKSEQQEIEGSLSQLSIPDLMQLLGMNRRSGRLTLERGNDRGEISVVEGRPVNAKLGRVEGEKALFRLLAWVDGTFTFSPGGNTARPRINRGMDDALLEGMRQSDEVNRLMPGLPPRHTRLMLAPDADLQGDQHPVTQQVVDLLRQPRALGEVLDLAPATDLEVLNVLTTLMQRGVARAADGDGVEAASGELLGAAEVHALRGRILRTRAPAKVATAKIFVCGSGASAARRVLSRMPGMEALSAEPTAVKSGFGTLGRLVLSEVLRLDFCVLPPAEAARPLWRPFTAGAMGALLMDVAEPSVRLAHYLAWEVRMPVVVVGAEVPAALQGAPAGALGATDDLADALRSLLVQALNPAPTLPGVPQVQRAAASIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2K0</accession>
    <name>LPXC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="1">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="1">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxC</name>
        <name type="ordered locus">MXAN_4967</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554945.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D2K0"/>
    <dbReference type="SMR" id="Q1D2K0"/>
    <dbReference type="STRING" id="246197.MXAN_4967"/>
    <dbReference type="EnsemblBacteria" id="ABF86238">
        <property type="protein sequence ID" value="ABF86238"/>
        <property type="gene ID" value="MXAN_4967"/>
    </dbReference>
    <dbReference type="GeneID" id="41362252"/>
    <dbReference type="KEGG" id="mxa:MXAN_4967"/>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046528_1_0_7"/>
    <dbReference type="OMA" id="IVFYRSD"/>
    <dbReference type="OrthoDB" id="428602at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000253679" description="UDP-3-O-acyl-N-acetylglucosamine deacetylase">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <sequence length="314" mass="33952" checksum="685DD9EB32EAC0CB" modified="2006-07-11" version="1">MRPSSYNQRTLSKIASLQGVGLHSGARVTLTLRPAPPGHGIVFVRTDLARPVSIPALAEYVVDTSLATTLGRDGVRVGTVEHLMAALAGMGIDNLRVELDGPEVPIMDGSAAPFAALIQSAGVREQEAPKELLVIRKAVSVVDGDKQASLTPARHFRISCTIDFEHPVIQGQSFDLDFGDRDFAREISRARTFGFLRDVEKLKQMGLARGGSLENAIVVDEVSILNPDGLRFPDEFVRHKILDAIGDVSLFGRPVIGHMTAYKTGHALNHKLVRKVMSDPSCYEIVPARRRELEGMGLGFSGLAGALDFEPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2K8</accession>
    <name>Q1D2K8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554937.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4959"/>
    <dbReference type="EnsemblBacteria" id="ABF92350">
        <property type="protein sequence ID" value="ABF92350"/>
        <property type="gene ID" value="MXAN_4959"/>
    </dbReference>
    <dbReference type="GeneID" id="41362244"/>
    <dbReference type="KEGG" id="mxa:MXAN_4959"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955888_0_0_7"/>
    <dbReference type="OMA" id="YEARARW"/>
    <dbReference type="OrthoDB" id="800792at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="32484" checksum="BA078BB13590ACE6" modified="2006-07-11" version="1">MHHPPEDTQRTHILDAIQKQKNALAPLRITGSPTEVGQGLVNLAELHGLLEDHAASRQFYEEALEKFQEAKYKPGQAQALMGLGVVKANFEDHRGAIEQIARAAMLFNESKDREGEALARACIGESLRSLGQPEAAEEKYQEALILLRQTRNTERVARLLIDIGDIRMEKGDYEPARKRFLEAVPLLEQGEDPEALALGHLLLGESEGLLGNHEGARPHLLRAVELYQEVHDHAYEARARWDLGLSCYYQQDFAAARKQFETLIPLYGDLGQTGEVAKVQNILAHFTARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2N6</accession>
    <name>Q1D2N6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="285"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="661" mass="70707" checksum="5BA40ACDF4206DD5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2U7</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
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            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="ABF88669.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="147" mass="15950" checksum="139F5E978A5B3889" modified="2006-07-11" version="1">MQARRNPGSRKTTCCESWDAPECLRCGGGAGDDANLVFPPHPGIRCAKGPSGPFREAVMRKALMLCAVLAVTPALAQDEGSNPGGPGEGNVRYSKTTNIDFEDDTIEGDLTKPDGEYIDARERVKHSNLIRIREDFEDKVMQSVGEL</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
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    </dbReference>
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        <location>
            <begin position="1790"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="3111"/>
            <end position="3144"/>
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    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="3185"/>
            <end position="3218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="3822" mass="421464" checksum="991572913C50AA9A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Y5</accession>
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            <fullName evidence="2">Flavin reductase domain protein</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
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                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="166" mass="17775" checksum="5C896DD9C5A1732C" modified="2006-07-11" version="1">MTQSTPEGVDARGFRDAMSRWASGVAVVAIQDTEGLRATTVSSFSSLSLDPPLVVVALSEASRTLKRVEASGVFTLSILSAAQRSISVQCAKGELDAQLFDADAFVRDSLVGLSCQVHGLHRHGDHTLIVGRVTRLHEGRPQEPLLYWARGYRTVTSLPPSDSDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
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                <person name="Eisen J.A."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
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    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="302"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="574"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="4">
        <location>
            <begin position="740"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="836" mass="90099" checksum="D5EDC35C23153442" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D300</accession>
    <name>Q1D300_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554798.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4812"/>
    <dbReference type="EnsemblBacteria" id="ABF91965">
        <property type="protein sequence ID" value="ABF91965"/>
        <property type="gene ID" value="MXAN_4812"/>
    </dbReference>
    <dbReference type="GeneID" id="41362111"/>
    <dbReference type="KEGG" id="mxa:MXAN_4812"/>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048238_0_0_7"/>
    <dbReference type="OMA" id="RFQNDGE"/>
    <dbReference type="OrthoDB" id="1688251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="36595" checksum="E8B96B94962F5ABF" modified="2006-07-11" version="1">MGFFPLVAFLERLTSQATRVGGAGPVNEEMIRFRHDPSLGFPSGDVSSVTLHQVPVRAEDPYSKRPLFEVVTRFLGLTGAVSPLPHYLAEEVAQEDPDHPVRREFLDLFHHRLLSLLYRIESKYRVTSETDTSFSDQWSRRLLALGGFDTYEKALEGTLPTWRLLRIAPLLASRARTSEQLEVALEDVLGDDLEGARVSVRQFVGRWVDIDARARLGHSNHQLGRNMLLGGKAFDRTGKIQIHIRPLPPRAYKRLMQEGDLLPLVREVVALFVRDPLEYDLELGLTEGVQHQFRLSSREPSQLGRDTWLGLSQQTQMSVPVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D344</accession>
    <name>Q1D344_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="4" type="ORF">MXAN_4767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554754.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4767"/>
    <dbReference type="EnsemblBacteria" id="ABF87790">
        <property type="protein sequence ID" value="ABF87790"/>
        <property type="gene ID" value="MXAN_4767"/>
    </dbReference>
    <dbReference type="GeneID" id="41362066"/>
    <dbReference type="KEGG" id="mxa:MXAN_4767"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_7"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="15539" checksum="3A1C77EE448E3EC5" modified="2006-07-11" version="1">MKVILASDHAGLELRQELVAALTARGVAHEDVGPVTRDSVDYPDFAARVSRAVTSGEATLGVLVCGTGIGMSIVANKHKGIRAALCTTEFEARMARAHNDANVLCLGQRVVGAGVGRAILEAFLSTAFEGGRHERRVQMIREAESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D352</accession>
    <name>Q1D352_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY</name>
        <name evidence="3" type="ORF">MXAN_4759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554746.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4759"/>
    <dbReference type="EnsemblBacteria" id="ABF90183">
        <property type="protein sequence ID" value="ABF90183"/>
        <property type="gene ID" value="MXAN_4759"/>
    </dbReference>
    <dbReference type="GeneID" id="41362058"/>
    <dbReference type="KEGG" id="mxa:MXAN_4759"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="ANFYLVK"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="14039" checksum="1E736FE823721253" modified="2006-07-11" version="1">MRVKVLIVEDSKASREYIAAMVEAVEGVEVVVTSSGFEALKLLPRHRFELIITDINMPDINGLELINFVKKNPNYREVPLFIITTEGRDQDRERGLALGAAEYLVKPFLPGSLEALLRRYLKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3C6</accession>
    <name>Q1D3C6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554672.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4681"/>
    <dbReference type="EnsemblBacteria" id="ABF86876">
        <property type="protein sequence ID" value="ABF86876"/>
        <property type="gene ID" value="MXAN_4681"/>
    </dbReference>
    <dbReference type="GeneID" id="41361979"/>
    <dbReference type="KEGG" id="mxa:MXAN_4681"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109169_1_0_7"/>
    <dbReference type="OMA" id="EYLWACR"/>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13670" checksum="C22081712ADA531E" modified="2006-07-11" version="1">MSRRRLPVLDANEPPLPPEGPEPPPSEDEAVEIPIDGNLDLHLFHPRDVKDLVVEYLWACRQKCVLDVRIIHGKGTGALRRTVQSLLPRLPEVESFRSAGEGDGGWGATWVRLRPADYDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U0</accession>
    <name>Q1D3U0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4515"/>
    <dbReference type="EnsemblBacteria" id="ABF91051">
        <property type="protein sequence ID" value="ABF91051"/>
        <property type="gene ID" value="MXAN_4515"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4515"/>
    <dbReference type="HOGENOM" id="CLU_3063777_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="53" mass="5914" checksum="FBB898324B82BD37" modified="2006-07-11" version="1">MLSSDNWTEDARASCLFARKMSARFISKLNYGADFRRATSPLIAMLDEVPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U3</accession>
    <name>Q1D3U3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RibD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554507.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4511"/>
    <dbReference type="EnsemblBacteria" id="ABF90277">
        <property type="protein sequence ID" value="ABF90277"/>
        <property type="gene ID" value="MXAN_4511"/>
    </dbReference>
    <dbReference type="GeneID" id="41361818"/>
    <dbReference type="KEGG" id="mxa:MXAN_4511"/>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073038_1_0_7"/>
    <dbReference type="OMA" id="MCGRITM"/>
    <dbReference type="OrthoDB" id="900513at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="26348" checksum="5BDEBF26BEE9A201" modified="2006-07-11" version="1">MRRAKRPYVICHMVPSIDGRIVTRNWKLSSRALSEYERTAETFDADGWMIGRISMEPYAGKAKVPVRKSGQPIPRTDFIARRDAESYAIALDPTGKLTWKFGSIDDEHVITILTEQVSDDYLAFLQSKGVSYLFGGKTELNLTRVLEKLRKDFGIKRLLLEGGGKINGSFLAEDLIDELSVLVAPIADGSIGTPSLFDAGEGRGPARHLKLVSCEPRKSDMLWLKYKVRKSESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3V1</accession>
    <name>Q1D3V1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate assembly protein W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554499.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4503"/>
    <dbReference type="EnsemblBacteria" id="ABF87619">
        <property type="protein sequence ID" value="ABF87619"/>
        <property type="gene ID" value="MXAN_4503"/>
    </dbReference>
    <dbReference type="GeneID" id="41361810"/>
    <dbReference type="KEGG" id="mxa:MXAN_4503"/>
    <dbReference type="eggNOG" id="COG3628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133204_0_2_7"/>
    <dbReference type="OMA" id="CGIHDYV"/>
    <dbReference type="OrthoDB" id="1791538at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="15059" checksum="0592B874B3785B8E" modified="2006-07-11" version="1">MSPKPPDRRPPVGFPLRLVPDERGELAFPSLEASVRQSIEVILRTRPGEQLMRQGFGAGLERMVGQPNTVSTRRRIQELVQRALTEWEPRLELIRVDVLELADLPAQVRVEIVYRLRRTGDVQQLGLAMDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D427</accession>
    <name>Q1D427_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554424.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4425"/>
    <dbReference type="EnsemblBacteria" id="ABF90867">
        <property type="protein sequence ID" value="ABF90867"/>
        <property type="gene ID" value="MXAN_4425"/>
    </dbReference>
    <dbReference type="GeneID" id="41361737"/>
    <dbReference type="KEGG" id="mxa:MXAN_4425"/>
    <dbReference type="HOGENOM" id="CLU_1609047_0_0_7"/>
    <dbReference type="OMA" id="DSSTAWY"/>
    <dbReference type="OrthoDB" id="1869500at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188104" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="16940" checksum="7EE6A6F5C9A8254C" modified="2006-07-11" version="1">MRLPIVSAALALAAAGCATPGFDKLYPGMSSHQVVDAMGSGPTRAQEFPDSSTAWYYGEDRCVLMRDDKLVAKATSEDSTTINTPVVSVRDTSKALCAPEGYASSEKREQVIDTPFGTLKGNIDPKAAMEKVKGVVTGKSGDTAPAKTGAAPAETEQASTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D452</accession>
    <name>Q1D452_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase/cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4398"/>
    <dbReference type="EnsemblBacteria" id="ABF86433">
        <property type="protein sequence ID" value="ABF86433"/>
        <property type="gene ID" value="MXAN_4398"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4398"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658519_0_0_7"/>
    <dbReference type="OMA" id="LWSFVQV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="278"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="45596" checksum="42A8AC07215B649B" modified="2006-07-11" version="1">MALTTEAFGLTDVGRRRQHNEDAMLVDAALGLYVVADGMGGHAAGEVASNRATEVVKQHISANRHLLKDLGINPTPDSRSAAAALVEVAVQRACADIYRTAMSDATKRGMGTTFVCLAVGGNKGVIGHVGDSRVYLVRHGQCHRLTEDHTLVAAQLKAGTITKDQAANSQYRNVITRAVGIQESVQVDTLIVDLVPGDMFILCSDGLHGYVEDEEVLPLIAGIAPADLPKRFIDVANERGGKDNITAVVVKVAGEGSSVSEESSEAQSRMEALRKIPLFRHLTYKEQTAVLSIATTRTYPAGREIVVEGQPGEELFVVIRGRVAIEKNGVEIAELRAGGHFGEMGLIDNAPRSATVRATEPTRTMVISRPDLMGLMKRESILAVKMLWSFVQVLSDRLRATNSELSEARQELAVAQAIAPFAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D469</accession>
    <name>Q1D469_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4381"/>
    <dbReference type="EnsemblBacteria" id="ABF88646">
        <property type="protein sequence ID" value="ABF88646"/>
        <property type="gene ID" value="MXAN_4381"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4381"/>
    <dbReference type="HOGENOM" id="CLU_1420117_0_0_7"/>
    <dbReference type="OMA" id="CENDRFA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="23360" checksum="45963C2C79AF14EC" modified="2006-07-11" version="1">MLARKRRRPRIPSEPFAMSTVPTQPAQKSGKNTILIIAAVAVVVGGIGAATLLLGRQPSDVGSLGKTDVGGLQELAVIQAQLRPLRACGIEYGERGRRMKSGSHTSVWVSACENDRFAGVRIEVPTSRQVEGVAFDLERSSVSELWKILVDKNQVPFPELKRTLEQLTPYLVEEIPSRLAQAIEAKVAADRERQKHQAAEPARREASKNSYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q3</accession>
    <name>Q1D4Q3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554198.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90925">
        <property type="protein sequence ID" value="ABF90925"/>
        <property type="gene ID" value="MXAN_4195"/>
    </dbReference>
    <dbReference type="GeneID" id="41361512"/>
    <dbReference type="KEGG" id="mxa:MXAN_4195"/>
    <dbReference type="eggNOG" id="ENOG503330I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382816_0_0_7"/>
    <dbReference type="OMA" id="KTHDYGY"/>
    <dbReference type="OrthoDB" id="1355930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="21476" checksum="91D686D1F505BD02" modified="2006-07-11" version="1">MLVRNAPVSARRPANSPSESPAAEKPNAAAAPAAIHQKDSFSNTTTALQRTAKVGAAPAGDHGKLMMEYLTGARPPPADFEKVIGYKPYAIQTPHGQRMQDPLGYASVPLKIGPDKEFDPAAKTHDYGYDLLRYFDKKGTPLGPDARKAADALFRKDMFDYANDQKGALNRFKYRSWAQIYATAVELNSKRQGNGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S8</accession>
    <name>Q1D4S8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87014">
        <property type="protein sequence ID" value="ABF87014"/>
        <property type="gene ID" value="MXAN_4170"/>
    </dbReference>
    <dbReference type="GeneID" id="41361488"/>
    <dbReference type="KEGG" id="mxa:MXAN_4170"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021908_0_0_7"/>
    <dbReference type="OMA" id="TRTYDPC"/>
    <dbReference type="OrthoDB" id="666169at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="600" mass="65090" checksum="1FDF371250970828" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Y3</accession>
    <name>Q1D4Y3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FolB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4112"/>
    <dbReference type="EnsemblBacteria" id="ABF86875">
        <property type="protein sequence ID" value="ABF86875"/>
        <property type="gene ID" value="MXAN_4112"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4112"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112632_0_2_7"/>
    <dbReference type="OMA" id="IDLAMGW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:folic acid-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
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    </dbReference>
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        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="85" mass="9301" checksum="2FAECDF345D6E7CE" modified="2006-07-11" version="1">MFDLEMGVDNRKPAATDDIAHTLNYKAVSKRLIEFVGQSDFGLVETLAERCAAIVLEEFGVQWLRLKLSKPGAVRGARGGGAHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D508</accession>
    <name>Q1D508_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GufA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4087"/>
    <dbReference type="EnsemblBacteria" id="ABF92021">
        <property type="protein sequence ID" value="ABF92021"/>
        <property type="gene ID" value="MXAN_4087"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4087"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_2_7"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="25947" checksum="9B3817C00559844D" modified="2006-07-11" version="1">MGAGLVASLLAGTATGLGALPVLVTSELSRKAQDRMLGFSAGVMLAATSFSLVIPAMELVRGQGHDGPSAALRVAAGVLLGGLFLRVWHDLMPHEHALKGHEGHGGTKWNSALLFVLAMTLHNFPEGLAVGVSFAAPQPELGLSVALGIGAQNIPEGLVVALALRASGASASRAAFLALLTGMVEPVGALFGVLALSLSSALLPWGLAFAGGAMLYVISHEMIPESHRGGFEREATTGLMWGFVLALVLDMSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D516</accession>
    <name>Q1D516_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mchC</name>
        <name evidence="7" type="ORF">MXAN_4079</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK 1622</strain>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria.</title>
            <authorList>
                <person name="Burgard C."/>
                <person name="Zaburannyi N."/>
                <person name="Nadmid S."/>
                <person name="Maier J."/>
                <person name="Jenke-Kodama H."/>
                <person name="Luxenburger E."/>
                <person name="Bernauer H.S."/>
                <person name="Wenzel S.C."/>
            </authorList>
            <dbReference type="PubMed" id="28128551"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DK 1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX622595">
        <property type="protein sequence ID" value="APZ78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4079"/>
    <dbReference type="EnsemblBacteria" id="ABF88385">
        <property type="protein sequence ID" value="ABF88385"/>
        <property type="gene ID" value="MXAN_4079"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4079"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_223631_0_0_7"/>
    <dbReference type="OMA" id="GCRTWIT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="961"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2001"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3049"/>
            <end position="3124"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4093"/>
            <end position="4168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2036"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3084"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="APZ78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="4465" mass="486825" checksum="CEEAE25BEDDB43BD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D561</accession>
    <name>Q1D561_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88908">
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        <property type="gene ID" value="MXAN_4033"/>
    </dbReference>
    <dbReference type="GeneID" id="41361364"/>
    <dbReference type="KEGG" id="mxa:MXAN_4033"/>
    <dbReference type="HOGENOM" id="CLU_197513_0_0_7"/>
    <dbReference type="OMA" id="THRNLNC"/>
    <dbReference type="OrthoDB" id="1832009at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="77" mass="8746" checksum="3D85DB4A2B03989B" modified="2006-07-11" version="1">MKPCPADLPQTINPEAGPKRAGVETHRNLNCHQYDNCLDEAVRRGWQSFTCMKCPMYQQVAPPQMGLEAYATQRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5P5</accession>
    <name>Q1D5P5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553858.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3846"/>
    <dbReference type="EnsemblBacteria" id="ABF86783">
        <property type="protein sequence ID" value="ABF86783"/>
        <property type="gene ID" value="MXAN_3846"/>
    </dbReference>
    <dbReference type="GeneID" id="41361179"/>
    <dbReference type="KEGG" id="mxa:MXAN_3846"/>
    <dbReference type="eggNOG" id="COG0009">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01300">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="22215" checksum="AB6BC9A6F3970740" modified="2006-07-11" version="1">MAAPILEVDTEHPSPRHIQRAVEVLERGGLLAYPTDTYFGLGCDLSSKKGIERLYQLKGRDKKKPLSFLCPDLSDVARYAHVSNFAYRTMKSLTPGAFTFILEATRLVPDLMMSKQKQVGIRVPDSALVRELTRALGRPLVTTSATNTEGEPLTDAKDIKADLGHGLDLILDGGVTLNEPSTVISLIGDSLEILRQGKGRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Q9</accession>
    <name>Q1D5Q9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553844.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3832"/>
    <dbReference type="EnsemblBacteria" id="ABF87397">
        <property type="protein sequence ID" value="ABF87397"/>
        <property type="gene ID" value="MXAN_3832"/>
    </dbReference>
    <dbReference type="GeneID" id="41361165"/>
    <dbReference type="KEGG" id="mxa:MXAN_3832"/>
    <dbReference type="eggNOG" id="COG3359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035904_1_0_7"/>
    <dbReference type="OMA" id="HCARRVF"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="197"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="523" mass="55544" checksum="08CF8F9B7F870F6D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Q3</accession>
    <name>Q1D6Q3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553506.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3474"/>
    <dbReference type="EnsemblBacteria" id="ABF87643">
        <property type="protein sequence ID" value="ABF87643"/>
        <property type="gene ID" value="MXAN_3474"/>
    </dbReference>
    <dbReference type="GeneID" id="41360821"/>
    <dbReference type="KEGG" id="mxa:MXAN_3474"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_0_7"/>
    <dbReference type="OMA" id="GVAKDQM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="540" mass="58815" checksum="0540760B2525441A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6W3</accession>
    <name>Q1D6W3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553446.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3413"/>
    <dbReference type="EnsemblBacteria" id="ABF86388">
        <property type="protein sequence ID" value="ABF86388"/>
        <property type="gene ID" value="MXAN_3413"/>
    </dbReference>
    <dbReference type="GeneID" id="41360760"/>
    <dbReference type="KEGG" id="mxa:MXAN_3413"/>
    <dbReference type="HOGENOM" id="CLU_1957217_0_0_7"/>
    <dbReference type="OMA" id="KDGVHVM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188444" evidence="2">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="14824" checksum="99D4047F2C8F9700" modified="2006-07-11" version="1">MSPQPVRPRLTSLAVVTLALLTPALALAHGKDGVHVMGTVKEVKQAALVLETSDKKQQEVMTDPGTRYEKSGVAVTASDLKPGERAVVHGMKMNNGQVHAQLVKFGKPPAKGTGKDQGGTGETEPAPTPPTQGKRHEHSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D709</accession>
    <name>Q1D709_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3367"/>
    <dbReference type="EnsemblBacteria" id="ABF93149">
        <property type="protein sequence ID" value="ABF93149"/>
        <property type="gene ID" value="MXAN_3367"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3367"/>
    <dbReference type="HOGENOM" id="CLU_1675984_0_0_7"/>
    <dbReference type="OMA" id="SAWVCEL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20135" checksum="C1F06C75714BBC3F" modified="2006-07-11" version="1">MGTGWLNAPSVESRARRPYVGDLKVGNRGTSMGARHTRLAAALAAAWEAEVVSARRMTALAERIVDARVRARLMVLAAFCRAHASRLLARLAALGRGPLPVPPEDIELDSDTLLELRREGAFARASAARYETTAELARQQADLSSAWVCELNRTEEQDRSRELLSLAEGALGPVVHADAPASAAPGDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D751</accession>
    <name>RS13_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">MXAN_3323</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553358.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D751"/>
    <dbReference type="SMR" id="Q1D751"/>
    <dbReference type="STRING" id="246197.MXAN_3323"/>
    <dbReference type="EnsemblBacteria" id="ABF90638">
        <property type="protein sequence ID" value="ABF90638"/>
        <property type="gene ID" value="MXAN_3323"/>
    </dbReference>
    <dbReference type="GeneID" id="41360676"/>
    <dbReference type="KEGG" id="mxa:MXAN_3323"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_7"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000306658" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="127" mass="14214" checksum="C4BEA294403365C5" modified="2006-07-11" version="1">MARIAGIDLPPNKRAVISLQYIYGIGNKSAQDIIAAAGIDPTTRTKDLTEEQARKIREIIEASYKVEGDLRREVTMNIKRLMDLGCYRGLRHRKGLPVRGQRTHTNARTRKGPKRGIVRAKPAAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7C7</accession>
    <name>Q1D7C7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3247"/>
    <dbReference type="EnsemblBacteria" id="ABF90685">
        <property type="protein sequence ID" value="ABF90685"/>
        <property type="gene ID" value="MXAN_3247"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3247"/>
    <dbReference type="HOGENOM" id="CLU_555291_0_0_7"/>
    <dbReference type="OMA" id="AVARHCH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="58365" checksum="9E265EBFA54B432E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F1</accession>
    <name>Q1D7F1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553268.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3223"/>
    <dbReference type="EnsemblBacteria" id="ABF88672">
        <property type="protein sequence ID" value="ABF88672"/>
        <property type="gene ID" value="MXAN_3223"/>
    </dbReference>
    <dbReference type="GeneID" id="41360577"/>
    <dbReference type="KEGG" id="mxa:MXAN_3223"/>
    <dbReference type="eggNOG" id="COG2947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_2_1_7"/>
    <dbReference type="OMA" id="LWDGIRN"/>
    <dbReference type="OrthoDB" id="1829674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="142" mass="15647" checksum="8C2AC3E63C04D258" modified="2006-07-11" version="1">MAKPQYWLIKSEPSVYAYAQLEKDGKTEWTGVRNFEARNNIRAMKPGDLCLYYHSNEDKAVVGVAQVLTPPGPDSTVPDEDWAATFMGPVVPFTQPVDLATIKATAALKDFPLVTRGRLSVAPVTATHFKQVLKMGKTVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7I9</accession>
    <name>Q1D7I9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553230.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3181"/>
    <dbReference type="EnsemblBacteria" id="ABF93056">
        <property type="protein sequence ID" value="ABF93056"/>
        <property type="gene ID" value="MXAN_3181"/>
    </dbReference>
    <dbReference type="GeneID" id="41364718"/>
    <dbReference type="KEGG" id="mxa:MXAN_3181"/>
    <dbReference type="HOGENOM" id="CLU_969186_0_0_7"/>
    <dbReference type="OMA" id="PRWAPRE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011754">
        <property type="entry name" value="Mxa_paralog_2268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09544">
        <property type="entry name" value="DUF2381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02268">
        <property type="entry name" value="TIGR02268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188457" evidence="1">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="30792" checksum="5DA93D5195680C85" modified="2006-07-11" version="1">MLQPSRLALALALVWGAAVEAQPSAAARMRRERVVTVPGAAAEPLPVVHVAHDTPTLLLFPAPINRKTLTFDESRIRILDAGERSVIVQPVADLPEGERYEVGVFFADGRAPARAAFSLVTDPAEVDTRIDVQRPELADMACPVDVPRTPRPEDFVLLGYVDKEGVTATPIKLHADSERGFSVISAMAYRGQGWVLVDATIRNYPGRAPWVPREAMLTGRAGLPLRARLVTVDEGAFVPGGFGRILAVAETAQLSNSPVYTLEVVGDGRTLTIPNVRLPKAVSGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L5</accession>
    <name>Q1D7L5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553204.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87821">
        <property type="protein sequence ID" value="ABF87821"/>
        <property type="gene ID" value="MXAN_3155"/>
    </dbReference>
    <dbReference type="GeneID" id="41360514"/>
    <dbReference type="KEGG" id="mxa:MXAN_3155"/>
    <dbReference type="HOGENOM" id="CLU_119555_0_0_7"/>
    <dbReference type="OMA" id="DTHARCK"/>
    <dbReference type="OrthoDB" id="2161129at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188242" evidence="1">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="14875" checksum="DD592FF959045783" modified="2006-07-11" version="1">MPKTKLSASLLIVLASLALGCSSGATAAASRREVSTPATTCLDTISCCLQRHPAQPELCGLSASEAVVYLAEIQAVAKEREANRDDGAKAGWKRRCVDTHARCKDAGRGRWVGDCYACFVRCEREREWPYDSCHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D863</accession>
    <name>Q1D863_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553007.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2950"/>
    <dbReference type="EnsemblBacteria" id="ABF88009">
        <property type="protein sequence ID" value="ABF88009"/>
        <property type="gene ID" value="MXAN_2950"/>
    </dbReference>
    <dbReference type="GeneID" id="41360313"/>
    <dbReference type="KEGG" id="mxa:MXAN_2950"/>
    <dbReference type="HOGENOM" id="CLU_079601_0_0_7"/>
    <dbReference type="OMA" id="CHNGHCH"/>
    <dbReference type="OrthoDB" id="1425758at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30244" checksum="149CB39BC9618F41" modified="2006-07-11" version="1">MRTRLLLPLLFISGCALEPGESFAVLEPAVRADYTPVAGRDEGNGFQRLASDFELRLDGAALGVDHIDLVGGGGTRGPTTFDPANPPPGYTNCHNGHCHHDDGALVDYEDIQAELDGGGGGAEATVASLHVDADLDLLADQTLSPDCEPSCELGRTHVSRYQWDVSSVMLEGAVRDSRATPRFNDERRFRLALAAAEEATPLMVLRGTVDIPADRENKPRVKLALRLALTPTLFDSLDWAATTPGPDGVVDLNAPENAAIRTAMVEALATLEPQAEVRREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8F0</accession>
    <name>Q1D8F0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2862"/>
    <dbReference type="EnsemblBacteria" id="ABF88180">
        <property type="protein sequence ID" value="ABF88180"/>
        <property type="gene ID" value="MXAN_2862"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2862"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587808_0_0_7"/>
    <dbReference type="OMA" id="TVREWIA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="579" mass="63518" checksum="D0B651714B716C44" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K9</accession>
    <name>Q1D8K9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552864.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2797"/>
    <dbReference type="EnsemblBacteria" id="ABF91178">
        <property type="protein sequence ID" value="ABF91178"/>
        <property type="gene ID" value="MXAN_2797"/>
    </dbReference>
    <dbReference type="GeneID" id="41360173"/>
    <dbReference type="KEGG" id="mxa:MXAN_2797"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993315_0_0_7"/>
    <dbReference type="OMA" id="ETRWLVY"/>
    <dbReference type="OrthoDB" id="1277929at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="29435" checksum="3FBDBEBCD547BAB0" modified="2006-07-11" version="1">MRGARFRVNQRFPLVTAAVLAVGILMVGLTRDDADLPGPFPYTGAPLSAEERARLASEGWTVTGPDAPPRLVALTRPPSAGETRWLVYFGGNTPGYLAEAKSVLLSLDEGRGLGLAAIAPPGFDGSPGKPSPEALRDSAASAMRWLTETHPAAAQDIHLVGFSMGTMSALAAAHALRAQETPARSLVLFAPFQAMKVGRMGLIGSLVGRHRYDNQPLLQPKRLPPALVLHGGADSALPPVQGERVSRGLRAPLKTYPGIGHAELLKHPPALADARQGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y5</accession>
    <name>Q1D8Y5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92095">
        <property type="protein sequence ID" value="ABF92095"/>
        <property type="gene ID" value="MXAN_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2669"/>
    <dbReference type="HOGENOM" id="CLU_155197_0_0_7"/>
    <dbReference type="OMA" id="MNDDMTR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="14608" checksum="73902B754254227F" modified="2006-07-11" version="1">MCRVLTTHKRVARLVPLPAPRARKKVGGRGRSLLNLLPMNDDMTRERLAQGVSELESRVGPPLPLAESLHKALDGAVFPLSARQLTWVARENEAPALVLSLLGSLPRASFGSVDAVARALEGDLEATVPQQSASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D925</accession>
    <name>Q1D925_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pkn9 associate protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">k9ap1</name>
        <name evidence="3" type="ORF">MXAN_2629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2629"/>
    <dbReference type="EnsemblBacteria" id="ABF91518">
        <property type="protein sequence ID" value="ABF91518"/>
        <property type="gene ID" value="MXAN_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2629"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549481_0_0_7"/>
    <dbReference type="OMA" id="FLYVERG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="51327" checksum="7B7D76625848B6E5" modified="2006-07-11" version="1">MGIMAPPNPKRPPRPPRPPGTQAPQDSDVELPFDDDEVDPLQADDPRPQRVPQFPAGSRRSRRQGPGGRANSDRELASRFDTANEYSDPGYAPAFLYVERGPGAGQLVPVKQGALVIGRSSSSDLRLQHPSISRRHAHLTRRGERFFLKDLSSQNGTFLNRHRITSEVELMPGDEVSLGNALLRLRGPGGTPALGVPAVSHDEKPPSRGALSTVGVALGAAALGSGVAALIALLSMRMAGGAEHTSPVPPPAAPQHAAAASPTVVASGAPTRLDMEVPAAGSAEKTGDTAVGAATATTENPPPEAENAPLTPKATGISALNVARGTTKQVRPVAVAPSNKRAAGARDSAAAPSDATSAKEAEVLRRYEAGDLAAARDLAQAEKLTALHGQLIRFETAEAQAKKALAQRDFPEAIAQLTLAISVDDALAHGWSKHGPPLRKQLSRLHVQVGTEHAAAGRVSEARAAFEQALKHDTGNREAREQLGRLTGASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D937</accession>
    <name>Q1D937_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552687.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2617"/>
    <dbReference type="EnsemblBacteria" id="ABF92294">
        <property type="protein sequence ID" value="ABF92294"/>
        <property type="gene ID" value="MXAN_2617"/>
    </dbReference>
    <dbReference type="GeneID" id="41359994"/>
    <dbReference type="KEGG" id="mxa:MXAN_2617"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001114_1_1_7"/>
    <dbReference type="OMA" id="QSFIVQA"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="7">
        <location>
            <begin position="498"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1220" mass="133463" checksum="A43E1F1D37AC9083" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D992</accession>
    <name>Q1D992_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2562"/>
    <dbReference type="EnsemblBacteria" id="ABF91942">
        <property type="protein sequence ID" value="ABF91942"/>
        <property type="gene ID" value="MXAN_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2562"/>
    <dbReference type="eggNOG" id="ENOG5030SMX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159557_0_0_7"/>
    <dbReference type="OMA" id="YKFDYAA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="28124" checksum="67724AA72AB0B9D9" modified="2006-07-11" version="1">MRDAGVPRSLAVVEEEAVMSRASALGVVALLATLPAWGQDTVVVEEEVSLRSPRSGGIQFRLGGYKPLIDEESGLTGTPYEDYFGGESLLTFEVELQRYFYQGVGTAGVGFSAGYGEKYGTAKLASGADAAERTALRLIPLSLNAFYKFDYAAFEWGIPLVPYGKLGLIYTPWWILKGTGTEAVGGNRGSGGKWGWGATGGVAFLLDVLEPRFARDFDSDLGVNHSYIFAEYTYADVDNFGGPGLNLSNRRWMFGLALDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D998</accession>
    <name>Q1D998_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552626.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2556"/>
    <dbReference type="EnsemblBacteria" id="ABF91043">
        <property type="protein sequence ID" value="ABF91043"/>
        <property type="gene ID" value="MXAN_2556"/>
    </dbReference>
    <dbReference type="GeneID" id="41359934"/>
    <dbReference type="KEGG" id="mxa:MXAN_2556"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_3_7"/>
    <dbReference type="OMA" id="VFDSFAY"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="29982" checksum="145A27C02EFEF614" modified="2006-07-11" version="1">MNDKNRNLVIRVVSAVTLLPLVLLLLFLGGYWSAALLGAAAAACVGEYYLIVQKRLTVASWVGMAFAAVLPFLPMRDAARTGETAFWLTIVFAFFAWIYHLFKGPLAEAPTRTAHLVNGFLYGAVGLTAVSALRLLPDHGLAWVICALVITWANDTAAYFFGRFLGKHKLYPEVSPNKTWEGFFGGMLGSVGGMFIARQFFFPVFTVWDCVLLGIAGGILGPVGDLCESMLKRAYGVKDSGVLIPGHGGVLDRIDALLFNAPLVFVYVQFVRGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I4</accession>
    <name>Q1D9I4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552541.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87148">
        <property type="protein sequence ID" value="ABF87148"/>
        <property type="gene ID" value="MXAN_2469"/>
    </dbReference>
    <dbReference type="GeneID" id="41359852"/>
    <dbReference type="KEGG" id="mxa:MXAN_2469"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043793_0_0_7"/>
    <dbReference type="OMA" id="WGRRTEE"/>
    <dbReference type="OrthoDB" id="985722at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="563" mass="61016" checksum="651ED7D5D81805DE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z1</accession>
    <name>Q1D9Z1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552387.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2312"/>
    <dbReference type="EnsemblBacteria" id="ABF88446">
        <property type="protein sequence ID" value="ABF88446"/>
        <property type="gene ID" value="MXAN_2312"/>
    </dbReference>
    <dbReference type="GeneID" id="41359699"/>
    <dbReference type="KEGG" id="mxa:MXAN_2312"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587701_0_0_7"/>
    <dbReference type="OMA" id="FFEADAS"/>
    <dbReference type="OrthoDB" id="537646at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188358" evidence="1">
        <location>
            <begin position="17"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="508" mass="56242" checksum="DF6F93ACA1768608" modified="2006-07-11" version="1">MILLSLLLAATPPVMLEPNAGSANRLHPRRVTASSFLENGWNKHAQNYLPLYIADDDPATAWVEGAKGRGEGEAIEWWGPELSRAKTYRLFLRNGFQKSEKLFRANARPRKVKLEPLVQGETGPQTTGTALEMELKDVLGWQEVRLPVPNKVHGVRLTLVSTYPGTSYDDTCLSDFRVYVEGEDPYKPEAEAAAFEQVRAFALERKQAAARSGSAAKMEWAPRYEVEKLLTLERSYEEGEPPRGNTYAVGLFSTVPVKDSYKSALDRAKKVAELFDRASLDYEGQDSEARAKWTRVKPAQPKAQTTSARTALSAMESDGIVRIAGLLHLGDASFFEADASQAQMLASIEKLDKKEAQQTKACISKCEKRRAGTREDSYDCSCADECMGCDDPNLPASEKLKHQVTGGDFLLGSLARPTAFLRGKSELSGSRESWYAFRQTLVTYAGEKADVVLTNDHTDMMMEGTVALRIHVIDWGESNGKASPTTITSFLVSETRVQVLRYRPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR4</accession>
    <name>Q1DAR4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2030"/>
    <dbReference type="EnsemblBacteria" id="ABF89091">
        <property type="protein sequence ID" value="ABF89091"/>
        <property type="gene ID" value="MXAN_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2030"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_7"/>
    <dbReference type="OMA" id="RIVFVYY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="128"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22725" checksum="944475226A651C83" modified="2006-07-11" version="1">MSGVPAQDEVRLQALVRRIQEGDLTAFEQLYALTQADASRTLWHLVGNRVDVEDLLQEAYLRLLTAVKSYRGESRFRTFFYRVCSNVALSHLRWKRRRPEDSVWDLPEAVAEGDDPERVASRRQAARLVELALERLKPKKRIVFVYYELCGMSPDEIADAVGSSPNTVRSRLHHARLEFNEAMQRLLGANRSGGFHGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB58</accession>
    <name>Q1DB58_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90504">
        <property type="protein sequence ID" value="ABF90504"/>
        <property type="gene ID" value="MXAN_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1869"/>
    <dbReference type="HOGENOM" id="CLU_943052_0_0_7"/>
    <dbReference type="OMA" id="WTRSEVW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="39818" checksum="7E76DA0E3BD8851B" modified="2006-07-11" version="1">MMRPTRTGYPDARCARSMSGAHDPCSSWQEQVGRAVHGEHAGAPLQRGGDAMDTTYRVARLPARLRAFALPDTSTPPEGYVEAGDYLVLEEKARYPTPDTDYSRLVVPQLGVLGMWVCTRWRTQRYATLASRERAPAMARLSFDDERLAVPEERLTTLLGAFLDYRYDGSRAYYPWALPGVRVQLAPPRLNNCCTFVEALLVKAFSEVHGAAFSWDARRHRQMMIASTQDYFSPVTAAVESGMALPAPSADVPPHPWTLIQGWRSQWGSGHTFLAVDHHPETDKVLVLESNAAFGLDGVGYRGLGNLRDVGLQPPAQWWTRSEVWTWRRICSTYPFRRQAWLKVTDPEVEGAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG1</accession>
    <name>Q1DBG1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87136">
        <property type="protein sequence ID" value="ABF87136"/>
        <property type="gene ID" value="MXAN_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1761"/>
    <dbReference type="HOGENOM" id="CLU_2917802_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="61" mass="6305" checksum="91A991BB9F228392" modified="2006-07-11" version="1">MQALRTLEFAGDQYPIPTSTQTPLEPRTAAASAARWAACTSSSATLAEAARGIALLTKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI6</accession>
    <name>Q1DBI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551846.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1737"/>
    <dbReference type="EnsemblBacteria" id="ABF90099">
        <property type="protein sequence ID" value="ABF90099"/>
        <property type="gene ID" value="MXAN_1737"/>
    </dbReference>
    <dbReference type="GeneID" id="41359170"/>
    <dbReference type="KEGG" id="mxa:MXAN_1737"/>
    <dbReference type="eggNOG" id="ENOG50317BE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574685_0_0_7"/>
    <dbReference type="OrthoDB" id="91612at68525"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="475" mass="53150" checksum="EF1031355D689552" modified="2006-07-11" version="1">MRSLLLPLLLSVAPAPSPEISSANLKKTPAFQDWRGGRFLFEERWVDLPEVGLRVGYFVVASRWTRQYADKLPFHDAFFVVDPRTGQLVAPALVRTSLPRNGCPTMGEVARLIPEPESETSAAIRFGNAPQRCLFRLQRTKEAWAASLFPDEAHSPVEAFPEAVAALEKALGPRDGGARELNWSYQPNSRWLLAASQDECALWVIDSINPEVNATASKAMTREICECLEGTVSADDPYIRLPQTAYTMSRMGAGTALPSCDCTFAQTGEAGVTCEAYMGRPYSLPEFEEMQKDGRLTEKNRVENLKELEDLRRTHQGLLAANEDALAQWKTGDQKAALSAWTTLYRTWLENGRPMAGGTLDEFAVEDATLREQLNQQLEATIDLRAEILNNLGFALWSHKEWSQAEAVLDECLALLTATGHERNVLNLNRGDLFRDMGKGPEAIKAYRSFLLRKVTAAQRKYAERELRKLEQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL1</accession>
    <name>Q1DBL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1711"/>
    <dbReference type="EnsemblBacteria" id="ABF86776">
        <property type="protein sequence ID" value="ABF86776"/>
        <property type="gene ID" value="MXAN_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1711"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_7"/>
    <dbReference type="OMA" id="YPVPDDM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="34051" checksum="95C3561E49259D30" modified="2006-07-11" version="1">MLELRHFKLIAAVADTGSLAAASRQLHLTSSALSHQLRDAEERLGVQLFQRRQRRLLLTGAGEKLLLSARRVLSEVAQAEAVCRAHPQDDLLRLSTGCYTVYGWLPPILGRWQAEHPRVELRIVLEATRQPLGALLNGELDLALTTDVPPQARLAQTALFEDELMLVVPEDHALARRGHVTAEDLVREHLLTYAAPREQLDVFTRVLWPAGIEPHRVSPVPLTEALIELVRGGIGVTALPQWMLPSQHPGLQTVRLTPQGIRRRWSAVTRASRQRPAPLTYFIQLLRERFSRHGKAGPRAASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBU1</accession>
    <name>Q1DBU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1630"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88793">
        <property type="protein sequence ID" value="ABF88793"/>
        <property type="gene ID" value="MXAN_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1630"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647105_0_0_7"/>
    <dbReference type="OMA" id="EHDGWVG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="67"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="43860" checksum="9BD822FAF366256B" modified="2006-07-11" version="1">MTGSTNTAVTWSVQEGAAGGTVTPAGLYTAPAIAGTYHVVATSQADPTKSAVATVTVPNTPPPPSGTWVSGYYTGWNADMYPPEKVDFSALTHILVGRVTPNPDGTVNTQFDNSNGPAIARTLSTRAHAAGRKAIIMVGGAGEHDGWVGAASNANRAQFVQNLLNAMDTFGYDGLDIDWEPVEQVDKPALLALIQALRAARPQMLLTMPIGWVNSNFPEDADPWFTNLVPYLDQMNVMTYEMTGPWGGWLSWYTSALTGEAGNHPTSVSSSLSAWANAGIPKNKLGMGIPFYGMAWRNITGPYQPYTDWSDYVGSDNSFTYSKILQLSATGVYHWDEAAKASYVTFDVPVEDGTVRWISYDSPQTIAAKGAFAHDNGYGGTIIWTINQGCTDPQTGANPLLDAVKNAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBY5</accession>
    <name>Q1DBY5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551697.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1586"/>
    <dbReference type="EnsemblBacteria" id="ABF87184">
        <property type="protein sequence ID" value="ABF87184"/>
        <property type="gene ID" value="MXAN_1586"/>
    </dbReference>
    <dbReference type="GeneID" id="41359031"/>
    <dbReference type="KEGG" id="mxa:MXAN_1586"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_7"/>
    <dbReference type="OMA" id="EWINNGW"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="29479" checksum="CABD8305462DB6A9" modified="2006-07-11" version="1">MARKQRTPRWLEAARRRGPEDVQPSGRSDWLARALGKAGVMPRAQAEAAIREGRVTLDGRVEHEPFAPVRPEMEVRVDGLVRNLEAPVLTLMFHKPAGLVVHGSDAEGVGTVFECLRERLTQPLRDYEWLAVGRLDRDTTGLLLFTNDERLVQHGTSPERHLPKRYVAGVVGPPPEDALRRLREGLVLEDGPTRPAGARLRAPDVVELTLTEGRNHQVKRMLAAVGHPVRTLHREAVGGVTLDVPEGAWRLLTDEEVSQGLSFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC20</accession>
    <name>Q1DC20_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein, GvpL/GvpF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1551"/>
    <dbReference type="EnsemblBacteria" id="ABF86944">
        <property type="protein sequence ID" value="ABF86944"/>
        <property type="gene ID" value="MXAN_1551"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1551"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065736_3_1_7"/>
    <dbReference type="OMA" id="YNFVNIR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30475" checksum="14A60729DB999980" modified="2006-07-11" version="1">MSRTTRPRKGAAHGDSRPAQAARPSPPTAETVTPDGPRYLYGIVRDTAPLDVGRIGLGIVPAQVYAVSEAGLAALVSVAPGRVVDPTRAHLLGHQRVTETLLREHTVIPVAFGTVMASEAQVRALLRTAQGELSGVLDALEGKVELGLKVLWHREHLAQRLVLEDAQLLRRDDEPEAEHERRLEAAVEDRAGRDMRALLEGLRPRAAAMREHPPVGERMLLNAAFLVERPRLEPFEEKVRSLAARSDTYTFRFTGPWAPYSFVDVHLGLRDEDASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ7</accession>
    <name>Q1DCJ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551486.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1369"/>
    <dbReference type="EnsemblBacteria" id="ABF86154">
        <property type="protein sequence ID" value="ABF86154"/>
        <property type="gene ID" value="MXAN_1369"/>
    </dbReference>
    <dbReference type="GeneID" id="41358815"/>
    <dbReference type="KEGG" id="mxa:MXAN_1369"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184012_0_0_7"/>
    <dbReference type="OMA" id="GHGAWFL"/>
    <dbReference type="OrthoDB" id="1456360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="24626" checksum="B936C5E2AF70D2AE" modified="2006-07-11" version="1">MSRRDARGMTLLEVSIVLAIIAVLAALAYAGYAQLSARAGPQNAAADLSGALAEARARAVDRQADVWLIIYPDINPEGQAGAGHGAWFLLEDRLRNFGDAAGAGGQLSFGTFSPPLDIQPSADQGRLMDAMYMDRYSQRTVRFGASGNLAWTGIFEGLAPTACSFCSGAPRRGAIVFRGDGSARFVDGAGQPVIPAGNGAVNRAASLALLSTDGQREYLFAVSAPVGFVDMRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ9</accession>
    <name>Q1DCJ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551484.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1367"/>
    <dbReference type="EnsemblBacteria" id="ABF86779">
        <property type="protein sequence ID" value="ABF86779"/>
        <property type="gene ID" value="MXAN_1367"/>
    </dbReference>
    <dbReference type="GeneID" id="41358813"/>
    <dbReference type="KEGG" id="mxa:MXAN_1367"/>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697956_0_0_7"/>
    <dbReference type="OMA" id="KHQANIR"/>
    <dbReference type="OrthoDB" id="542972at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="42731" checksum="D48762CF1F447870" modified="2006-07-11" version="1">MNAPRTHARRGFTLIELLVGITVSSVVLLAVAGTIIAVNNIFQSNTVSKTAVEGSRVGSDFLNRTLRYAGYGLDPAIAFDFGTMGLPEARKDNYTQEVEDWGNFVTDDLAFRYRDPMFLRRGQLDGTGAEPFQLELEPAATFGQPLRQGQAMLIACPGGQDYFLGRLTADVAADGTSATLNTALAAGLPGDVPKSCMTDTGRMPFVMLVHEKRLRVEAYGGRPYLVVKHGWAENADFDPIAVDVESFQVSYQMNRPPANSACCAGLPAPDGAVGSGMAWVLGDEDAVVLPKYDDHVPAPTYSTPYDAPLRYNMNPANIRSVGVGLTVRSARPLPSGTKNQGRRLFNADPVNPEDMFFRTTVETSVRIPNMTSRAFFIPELRAEGVAGDIKNVWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK5</accession>
    <name>Q1DCK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551478.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1361"/>
    <dbReference type="EnsemblBacteria" id="ABF91934">
        <property type="protein sequence ID" value="ABF91934"/>
        <property type="gene ID" value="MXAN_1361"/>
    </dbReference>
    <dbReference type="GeneID" id="41358807"/>
    <dbReference type="KEGG" id="mxa:MXAN_1361"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515712_0_0_7"/>
    <dbReference type="OMA" id="WLMLEAH"/>
    <dbReference type="OrthoDB" id="268932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="523" mass="57148" checksum="86CF779F41FADE84" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM7</accession>
    <name>Q1DDM7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551106.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0985"/>
    <dbReference type="TCDB" id="2.A.6.1.7">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86683">
        <property type="protein sequence ID" value="ABF86683"/>
        <property type="gene ID" value="MXAN_0985"/>
    </dbReference>
    <dbReference type="GeneID" id="41358441"/>
    <dbReference type="KEGG" id="mxa:MXAN_0985"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_14_3_7"/>
    <dbReference type="OMA" id="HIEIQRL"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188416" evidence="2">
        <location>
            <begin position="25"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="420" mass="44809" checksum="9721CC5B3B1C0AF2" modified="2006-07-11" version="1">MPHPLTVAAFGLAATLLFPRVAAAQPGSADAALSLEETLVLARQRAPALLDAAGRAAEAQGPVAAARSLLNDNPTFELQAGPRSAPGSPGNPAVRGLDLSVGISQSFELGGKRGARRESARAGLEMATAHQRDAERRVLGDVAARFLQALHARERLSLAREAEAAARETANSAQRRFEAGDVPVVDVNVARVSLARMRAEVATAEGDEAVQLHQLRAMLGLPLTHPLAIRGELRVLALQPVTEAKTDTVAARPDIAALEAELAQADADRRMGRASVWPDITAGFLYQREIDEIAYLGALSVPLPLFDRGDNARVTGEARVRRLQSLLAAARLEVDVQVEAARVQHRKRLEAVTLLEADALPLLSDNESLARRSYEAGEMGLAEFLLVRRDTLEARAAYLDSLLQAALSRVQLAVETGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT3</accession>
    <name>Q1DDT3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551050.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0929"/>
    <dbReference type="EnsemblBacteria" id="ABF89229">
        <property type="protein sequence ID" value="ABF89229"/>
        <property type="gene ID" value="MXAN_0929"/>
    </dbReference>
    <dbReference type="GeneID" id="41358388"/>
    <dbReference type="KEGG" id="mxa:MXAN_0929"/>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077096_1_0_7"/>
    <dbReference type="OMA" id="PRDIHRC"/>
    <dbReference type="OrthoDB" id="917815at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008164">
        <property type="entry name" value="XGLTT_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01744">
        <property type="entry name" value="GLTT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="36580" checksum="16E89C41B1023979" modified="2006-07-11" version="1">MRLMPAFLSGFRINHCLKHLRRPRIAGGLLGLALGFGGGACGPAELAGDTWTLCEAHGSAESGNGLSTNGLSTNGLSTNGLSTNGLSTNGLSTIGFSHWFNQDPARADELMRYIIRCAVKENQQRKYTNPVTGVKYTWEGGLGLALNWATGAPATAQEEEIVSACLAAHANKFGLPVAISVLGRNARGGALPYTEQELSTFSEREACFFGNLFDGTGVFAATDRGYLREDESTVRACGLPSNPAHSDCLPIIHAGTCESLCQRAATAALPFDRDADRKNPPPYGEPPYYETCTYNGRTFQPLTTRLQPRDIHRCGDGVCQLTERCGDGVEAGSCQADCGTCPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ8</accession>
    <name>Q1DEJ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0657"/>
    <dbReference type="EnsemblBacteria" id="ABF87689">
        <property type="protein sequence ID" value="ABF87689"/>
        <property type="gene ID" value="MXAN_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0657"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025153_0_0_7"/>
    <dbReference type="OMA" id="WKTSYRI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="585"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="681" mass="75861" checksum="40E21C90EE5BE02A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEU1</accession>
    <name>Q1DEU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0563"/>
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        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89521">
        <property type="protein sequence ID" value="ABF89521"/>
        <property type="gene ID" value="MXAN_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0563"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510669_0_0_7"/>
    <dbReference type="OMA" id="RGADTNP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="539" mass="57071" checksum="76D824A9B3D27DB3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF54</accession>
    <name>Q1DF54_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0449"/>
    <dbReference type="EnsemblBacteria" id="ABF89248">
        <property type="protein sequence ID" value="ABF89248"/>
        <property type="gene ID" value="MXAN_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0449"/>
    <dbReference type="HOGENOM" id="CLU_846854_0_0_7"/>
    <dbReference type="OMA" id="YADHTRS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="353" mass="38015" checksum="3D49CDF837A6B3F3" modified="2006-07-11" version="1">MTTSSTTTRRLPRTRSWSSAPMRPEGRFQALKGLAVATALVLPSVAAAGAVLEPKLSPSDNYGENFTFIGDLDGGTFIFVQLTVTNIGPGSRTGLCRTTVLTPGKKAWSAQTKVKARDWRYDAESSTLKMGPCSARSTDGATRVEVPLDGGRVLLEYAAPMTPQGQEGTEVEVGKDRYHHEVTLAFSALKATVKRPKGEDVVYTGGGYADHTRSTIAPAKLAKRWVRFRALLGGEKLVLLAREGQDGEYGPVYAWEEGAKARSLEHFTLAREGVKERSSWTVELFTDGSSAMVLRSTSLMQRSAPVEDLGAVLGGLVRSVVGSPVTYLHRAVLEREGKAPVTGLMEVTLEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFH0</accession>
    <name>Q1DFH0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550467.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0328"/>
    <dbReference type="EnsemblBacteria" id="ABF89825">
        <property type="protein sequence ID" value="ABF89825"/>
        <property type="gene ID" value="MXAN_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="41357827"/>
    <dbReference type="KEGG" id="mxa:MXAN_0328"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_22_1_7"/>
    <dbReference type="OMA" id="LYIERWP"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="18554" checksum="6C3C2621361DCCDE" modified="2006-07-11" version="1">MLLATVSIDLRAATAADAPFLFALYASTRESELAAWGWAPAQRDAFLRMQWVAQSHDWAARHPHADHQLVCLQGQPVGRLLVAKDAAAWRVVDIALLPAHQGSGVGTRLLTQVRDEAGKAGVPLRLRVLRTNPARRLYERLGFEVDAEPPEEAAAPYVALTWNPAPHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFP4</accession>
    <name>Q1DFP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550393.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0248"/>
    <dbReference type="EnsemblBacteria" id="ABF87631">
        <property type="protein sequence ID" value="ABF87631"/>
        <property type="gene ID" value="MXAN_0248"/>
    </dbReference>
    <dbReference type="GeneID" id="41357748"/>
    <dbReference type="KEGG" id="mxa:MXAN_0248"/>
    <dbReference type="eggNOG" id="ENOG5033G4G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124981_0_0_7"/>
    <dbReference type="OMA" id="KDNCVFD"/>
    <dbReference type="OrthoDB" id="1581144at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="20304" checksum="B47DA53CF24C50B1" modified="2006-07-11" version="1">MTWSQGRKRATKNGAMPRMTLLCLLVVMPLAGCHRTTFEDSVLTKPAVRYRIGKLPAYWEQVRLEDNDLAFAEEGTGRALSVNATCQGHDDPSLQVLTRHLLAGFTDRQEIAEQRIPMDGREALRSRHLAKMDGVPVQLELVVLKKDNCVFDFTYVSPPGLADGRMADFDALLAGFESERKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFQ2</accession>
    <name>Q1DFQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0240"/>
    <dbReference type="EnsemblBacteria" id="ABF90198">
        <property type="protein sequence ID" value="ABF90198"/>
        <property type="gene ID" value="MXAN_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0240"/>
    <dbReference type="HOGENOM" id="CLU_989815_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="281" mass="29940" checksum="BEB42A4C3B79F14D" modified="2006-07-11" version="1">MSSVSPRQEGGPVDGVAAGRFVLQLGGVRVDDAMHPVTGRQRGAQDELGPGVGLHGVSGGDEAEVVERRAGARPAADVEDDIAARVPVSAEGDAARLRVPVERAEREALGVLVDDAHGEGARALNLHRQLVVQCQRLAPAFRVTALEDAEFGRGELGEAHGHPAHEFLGGDPAVADDCPVVALEQGACPFFRELKPAWLVGVCVHGLVRHLALCLHRSHHDGDLFAGLHGAARRKSAACGGPVCPPWEGAWRRTSTRRAGRRSMSTWTCPRWCGRSTPRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT5</accession>
    <name>Q1DFT5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S8A (Subtilisin) subfamily</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550352.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0206"/>
    <dbReference type="MEROPS" id="S08.143"/>
    <dbReference type="EnsemblBacteria" id="ABF89812">
        <property type="protein sequence ID" value="ABF89812"/>
        <property type="gene ID" value="MXAN_0206"/>
    </dbReference>
    <dbReference type="GeneID" id="41357709"/>
    <dbReference type="KEGG" id="mxa:MXAN_0206"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574680_0_0_7"/>
    <dbReference type="OMA" id="TERRCNN"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="192"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="475" mass="50841" checksum="93D164DF77B3EF83" modified="2006-07-11" version="1">MKSYLLVPKESIETQARVGPRGTEQGERVLSRTTALRFAVANKAPDALFALGLRSATLPGARPPVSGQEERRRKGKGAKSARTGTRGADSSTPPMPGATVAEQTGAEPGSYRYMPLIGATMAHFYEDHTEKEARGELERDFEFIPDVVPLSFPGPVSAGQPGPRNRGMSSLAEREWPDECGVPLAHAQGIRGAGVMLGILDTGVDADHPEHAARVIQFRYVSLFPNSPHNPARDIRGFDPDGHGTHVCGIAAGVHHGVAPEVDLYVASVIESETIRTSLGRVAAGMEWLLHQFSRPENSTRPAVVNLSLGFPLMPPPGISEADYNLNLRALQTMIRRLLDSNVLPVVAAGNSGPDTVGYPAAFPESLAVGAVDFERNVATFSASGTVGRRVVPDIMGYGVNVYSSTERRCNNQAFYERMSGTSMAAPYVAGIAALYRCRAPDLTALEVRDLILSNAVKLPRSGTHKTGKGLAVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY7</accession>
    <name>Q1DFY7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550300.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0153"/>
    <dbReference type="EnsemblBacteria" id="ABF86249">
        <property type="protein sequence ID" value="ABF86249"/>
        <property type="gene ID" value="MXAN_0153"/>
    </dbReference>
    <dbReference type="GeneID" id="41357656"/>
    <dbReference type="KEGG" id="mxa:MXAN_0153"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_608097_0_0_7"/>
    <dbReference type="OMA" id="YTSECLL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="232"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="452" mass="48720" checksum="EA3B914994FC9C64" modified="2006-07-11" version="1">MSPRSAGRQALLSSFRRWTRAQDAAEVLAASGLGAWLALCAFVPSLLAMTAWAPGARSFFGIHFGTALLCAAPMLTSGVLFSLVHRRRRRIEPWGWGWLIFGVATMHFFVAALMALSAPPGAAVIASLFLFTTAFHGRLHRVTPRQPFLALGTALALALALPLRGSDEHLALFGVIGPAALTAQLYLGTFAVQHDRARADAERLRAAVHAQLLEQQERDVGRLSQALSEILGYHHDIDNALMAAGSAADMLAVVGAHRPGPGRTEFDDLLRQLNDNLTQIRDMMMDARNKGRRHAGMEPEPVELAPVLDSVQASVGLRFPDVDIQVEVEQPSPPLRALMRGGAPTLRRVVENLVLNACEGNGEEGAARVHIHARVEPLSGRLEVTITDDGPGFPPGQLSRPAEALYTSKSHATGLGLYTSECLLRASGGMLHRRNATGGGAVLRMVLPREYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG38</accession>
    <name>Q1DG38_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0102"/>
    <dbReference type="EnsemblBacteria" id="ABF89119">
        <property type="protein sequence ID" value="ABF89119"/>
        <property type="gene ID" value="MXAN_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0102"/>
    <dbReference type="HOGENOM" id="CLU_1085147_0_0_7"/>
    <dbReference type="OMA" id="FWNTEAP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28232" checksum="A754C53B876A8D85" modified="2006-07-11" version="1">MTEQEQFEEILRELGELLLQLGDLSWNVVLIGGQVLALESLRKGGSGVIAVTTDTGAVIERGYSHEPDLLFDMDGTEFGAERLPEVLKLRGYERTRSFRWSKTLPGGVMHLDLFAPAGVDLEQLPTSMTPLPDARLALRGSQPVFLPMGETSLRIRLPDAVGFLSMKVRAKLEQRPTETKDCFDIFAYVKLVGLDDVRASLKQAGEEGQALRDKLQRLFWSTDAAGVLDIIAYAEGLEEVDRALLAQAAVDLFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG76</accession>
    <name>Q1DG76_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ORF">MXAN_0064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550213.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0064"/>
    <dbReference type="EnsemblBacteria" id="ABF85892">
        <property type="protein sequence ID" value="ABF85892"/>
        <property type="gene ID" value="MXAN_0064"/>
    </dbReference>
    <dbReference type="GeneID" id="41357573"/>
    <dbReference type="KEGG" id="mxa:MXAN_0064"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_7"/>
    <dbReference type="OMA" id="YEISHNL"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="49098" checksum="0749256AC5CDEBD4" modified="2006-07-11" version="1">MSWKQRLEKVSEGHYVLAKTKSMKVDADLFLSDKLLWGEGPEQPGLEDSVFDQVVNAASFPGVTRVAVTPDCHLGYGVPIGTVVETDGILLPTAAGYDIGCGMVQLQTTLTAEDVADATKRRRWIEEVTKRIAVGVGASRVQKQRRVTDRTFADVVRHGAKALGRGSSVTERDYIPVEDDRVDIPERAFGKREQLGSLGGGNHFTEMQVDQDGRVWVMLHTGSRGFGWNIAKHFFVEGAAQLGLKSRSEDHVWLDAESPLGRDYWNLHNMAANFAVANRLIIGEAVCAALEDVFGGTASVYYEISHNLIQKEAGKFVARKGATRAFPGGHPALKGTPWEKTGHPILIPGSMETGSAILFAEPGAQKSIYSVNHGSGRRMSRGEARRVLKQDVTDKRMAEAGILLNTRQTPLDESGPCYKNLDDVLETVEMAGLARVAYRLKPVACIKGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG82</accession>
    <name>Q1DG82_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550207.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0058"/>
    <dbReference type="EnsemblBacteria" id="ABF89425">
        <property type="protein sequence ID" value="ABF89425"/>
        <property type="gene ID" value="MXAN_0058"/>
    </dbReference>
    <dbReference type="GeneID" id="41357567"/>
    <dbReference type="KEGG" id="mxa:MXAN_0058"/>
    <dbReference type="HOGENOM" id="CLU_1466726_0_0_7"/>
    <dbReference type="OrthoDB" id="2133072at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188534" evidence="1">
        <location>
            <begin position="24"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="20004" checksum="06D799919BCC5105" modified="2006-07-11" version="1">MRRFSRGLAVLLAVAGLSSAAASDDVVGYEAPSEEALRCLSEDLPVTVKVDYVLTGCWVFTQSTFYLKVTQSGAEVSGRGDDWEDPVKLSPRKLSRAEGERILQDLTSVMLRRESESASGHAPTRYVTTVEWVCGGVRGTKRGTVAFTAPAYDLYSTDEEEGDTSARAVGVRDVVVKALRQAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVI1</accession>
    <name>Q1CVI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90681">
        <property type="protein sequence ID" value="ABF90681"/>
        <property type="gene ID" value="MXAN_7489"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7489"/>
    <dbReference type="HOGENOM" id="CLU_3138053_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="49" mass="5091" checksum="335D3D464A73F7B6" modified="2006-07-11" version="1">MLGLPQLRAHGCSVQDDEPAGSINDVGLFRAMKTPRSAQTRQPGAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVI4</accession>
    <name>Q1CVI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87483">
        <property type="protein sequence ID" value="ABF87483"/>
        <property type="gene ID" value="MXAN_7486"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7486"/>
    <dbReference type="HOGENOM" id="CLU_1904479_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14533" checksum="97FE9E42930FCA73" modified="2006-07-11" version="1">MKPREASRMSQPRSSNAAMHSLLPSSLGTMKGRATRHIRSFPHPRSTWNSKGPAHEHVASVQRDHEFAPSRSTGNGGGTGLSKPLRSVRRPAHPSSCSKWNGSAKVDERSSKPCARSSPRAVRREHLGEHANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVI9</accession>
    <name>Q1CVI9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90398">
        <property type="protein sequence ID" value="ABF90398"/>
        <property type="gene ID" value="MXAN_7483"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7483"/>
    <dbReference type="HOGENOM" id="CLU_844198_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="36313" checksum="2BD5F4D553F20973" modified="2006-07-11" version="1">MFHVERRGDVQLECWARLARSSACSVPRGTCGRDGRARVRCFEAFHVERGWPQRHANTAVERASVLGSASSRVPRGTWTRLIEADEATWSATSWAPSSWMRWPSRMREMHAACSTWNANAWRAPVRVRGASPVPRGTWAGLGRELVGHGGAWSCGGFGGVRSTWNAATRHPWCWPAPMSSGLRLAPSSRWLGLRPLHQSPRGGVPASSRTRVPRGTKKRRMRCCFAVVGGRRSACALRGDGDGGGAPAHRIDSRMRSAWREFLTLGGKDARADACTSVKWMARLLMRGLLSACSTWNAGWIDGGHARSAGEFADGSAFRLVMRSWFMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVK6</accession>
    <name>Q1CVK6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative alanine dehydrogenase</fullName>
            <shortName evidence="1">AlaDH</shortName>
            <ecNumber evidence="1">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557370.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7463"/>
    <dbReference type="EnsemblBacteria" id="ABF90500">
        <property type="protein sequence ID" value="ABF90500"/>
        <property type="gene ID" value="MXAN_7463"/>
    </dbReference>
    <dbReference type="GeneID" id="41364609"/>
    <dbReference type="KEGG" id="mxa:MXAN_7463"/>
    <dbReference type="eggNOG" id="COG2423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_3_1_7"/>
    <dbReference type="OMA" id="VGLPWQD"/>
    <dbReference type="OrthoDB" id="1193876at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00935">
        <property type="entry name" value="AlaDH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028609">
        <property type="entry name" value="AlaDH_arch-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="34098" checksum="B96DF2A1ED17C7F5" modified="2006-07-11" version="1">MPTLILSAKDLRSLYTVELGLTAVERAFRAHGLGESLMPPKVYLSLPSYDGDFRAMPAFLDGAAGVKWVNAHPRNPEKHGLPTVRALYILSDPDTASPLAILDGTLLTAWRTGAAGGVASKFLAKKQPRTLGLVGCGVQARVLIDSHRALFGDNLELLLADTSEAAAKALQAEKGGRIVSTQEACGADIVCTATPARIPVVKREWFQPGVHINAMGADAPGKQELDARLLTEGRVFIDDTEQALHSGEVNVPRHDGLLRPEQIAGTLGEVVSGKKPGRTRATEITVFDSTGLALQDVALARALYDAALARGLGQSFDIIGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL6</accession>
    <name>Q1CVL6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557360.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7452"/>
    <dbReference type="EnsemblBacteria" id="ABF87170">
        <property type="protein sequence ID" value="ABF87170"/>
        <property type="gene ID" value="MXAN_7452"/>
    </dbReference>
    <dbReference type="GeneID" id="41364600"/>
    <dbReference type="KEGG" id="mxa:MXAN_7452"/>
    <dbReference type="HOGENOM" id="CLU_091669_0_0_7"/>
    <dbReference type="OMA" id="PWMFRAG"/>
    <dbReference type="OrthoDB" id="2113562at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20597" checksum="EBBD30CF82181265" modified="2006-07-11" version="1">MAPRYFDLSEDIQSGNWDLGDPRDAQGNEVEDPWMFRAGQPVQVQGRLTIPVDATGRRLDFSTAGIGVTPVVHVSVASLFAQLAPDDVQLIPVDVPGQPDSYLILVATKLIRCIDDEASQVQFWKPEDDLPEKVGQYSAVDSMHIDPSKVGDAKVFRTWGWDIALIVSEDLKSALEQSGATGMKFTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVX0</accession>
    <name>Q1CVX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557258.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86689">
        <property type="protein sequence ID" value="ABF86689"/>
        <property type="gene ID" value="MXAN_7340"/>
    </dbReference>
    <dbReference type="GeneID" id="41364501"/>
    <dbReference type="KEGG" id="mxa:MXAN_7340"/>
    <dbReference type="HOGENOM" id="CLU_1776324_0_0_7"/>
    <dbReference type="OMA" id="WIDESPA"/>
    <dbReference type="OrthoDB" id="1598542at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="18273" checksum="03ADDE7AD5B2E2E1" modified="2006-07-11" version="1">MDLRVLALPRSAWLSVGSPAVLRGASRMKLLRPCLGALLAAGLFLVPTNSEAAVRVGLGADYWIDDSAVFNFTLGVETPLAGPLSVGARFGAMLITEGNDIGVPLDLVLRANLAKSGVYIEGMVGPWLVFGRGDTFRAHAAFGFGLQGKAASIGLEVGYLEPNPTIGLRLGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW32</accession>
    <name>Q1CW32_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cmr5</name>
        <name evidence="6" type="ORF">MXAN_7278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557197.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7278"/>
    <dbReference type="EnsemblBacteria" id="ABF90455">
        <property type="protein sequence ID" value="ABF90455"/>
        <property type="gene ID" value="MXAN_7278"/>
    </dbReference>
    <dbReference type="GeneID" id="41364443"/>
    <dbReference type="KEGG" id="mxa:MXAN_7278"/>
    <dbReference type="eggNOG" id="COG3337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1873194_0_0_7"/>
    <dbReference type="OMA" id="WFRRAVQ"/>
    <dbReference type="OrthoDB" id="1844429at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="15210" checksum="1B73F65F21840C86" modified="2006-07-11" version="1">MTAQTREQQRALDVYARVRTARDKGKALCAEYKPRVNGLGAAVLRDGLAAALAFLEREVKSNAAAQHLLEDLTWCLERARLPGLSEPSLKRLGLPGAVRALGLNEYMLATRESLRLLVWFRRAVQATFPLEEREHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW33</accession>
    <name>Q1CW33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein Cmr6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmr6</name>
        <name evidence="2" type="ORF">MXAN_7277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557196.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7277"/>
    <dbReference type="EnsemblBacteria" id="ABF89853">
        <property type="protein sequence ID" value="ABF89853"/>
        <property type="gene ID" value="MXAN_7277"/>
    </dbReference>
    <dbReference type="GeneID" id="41364442"/>
    <dbReference type="KEGG" id="mxa:MXAN_7277"/>
    <dbReference type="eggNOG" id="COG1604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053305_1_1_7"/>
    <dbReference type="OMA" id="GHGNASP"/>
    <dbReference type="OrthoDB" id="1359321at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010172">
        <property type="entry name" value="CRISPR-assoc_prot_TM1791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39965">
        <property type="entry name" value="PTHR39965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01898">
        <property type="entry name" value="cas_TM1791_cmr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="39254" checksum="ADEF8A66984F6E68" modified="2006-07-11" version="1">MRDALGRVAGRVEKTSHAGLVYERYAPEKKHESQSGPWEAWLARLEAHPEPDDYADAFIRWKDSLRQSYTATFTARAESRLLVGHGNASPTGVGLTLHHTWGVPVVPGSSLKGVLAGYLRAVYGDAAMEARRRLFGVPGEDGEGAHAGEVIFHDAQWVPYRRVTGADRSPTFLSRDVLTVHHAGWYGGTSSWPNDYESPNPVAFLSVRPRGCFLVALSLAPGMEADAQAEAFLKWTAQRLDEALRHWGVGGKTAAGYGRLVREGPLELQRPQRPVRASPALTEFLSWVEARRADKVEQRQVLVGFEAEWLERLVSLAPEAREAGAKALRSLVKNPKLEARRDELLARMGVAVGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW90</accession>
    <name>Q1CW90_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557139.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7220"/>
    <dbReference type="EnsemblBacteria" id="ABF86349">
        <property type="protein sequence ID" value="ABF86349"/>
        <property type="gene ID" value="MXAN_7220"/>
    </dbReference>
    <dbReference type="GeneID" id="41364389"/>
    <dbReference type="KEGG" id="mxa:MXAN_7220"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_9_0_7"/>
    <dbReference type="OMA" id="GPTIGMW"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187837" evidence="2">
        <location>
            <begin position="27"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="242"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="468" mass="52645" checksum="C839F1699824B2BC" modified="2006-07-11" version="1">MRTRTLLLAPLLLSTSCATVSPKAQAPDATTAEAKSPAPERPFGTLREQAKRQQAWLAERVEKALPQLMRQYGVDMWVIPMREYNEDPVFKALVSPTSFAARRRTIYVFFDRGPEQGVERLALGGGSQGGLYTPRRAQRQVDGGGVSREAELWGPEQWQVLKQVVEERQPKRIALNVSRTFAFADGLSHGEYEGMSEALGPDWVKRFTSVDGLAVDFIAWRSADEARFYEEQTKLAWNIIETAFSNQVITPGVTTTRDVEWWMRQRLADLGLETWFQPSVDLQRQGVTEKELGEDPIIQRGDVLHCDYGVTALGLNTDTQHMGYVLREGETDVPAGLKAALKTSNRLQDIVFEELRPGRTGNDILRTSRERMRAEGIDGTVYSHPIGLHGHGAGPMVGLWDRQEGVPGNGDHKVIANQWYSIELQATSVVPEWNGQQVRSAQEEDITIDAEGRVHWAWKRQTDFHLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWA0</accession>
    <name>Q1CWA0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557129.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86314">
        <property type="protein sequence ID" value="ABF86314"/>
        <property type="gene ID" value="MXAN_7210"/>
    </dbReference>
    <dbReference type="GeneID" id="41364380"/>
    <dbReference type="KEGG" id="mxa:MXAN_7210"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1330074_0_0_7"/>
    <dbReference type="OMA" id="PHAFFAV"/>
    <dbReference type="OrthoDB" id="1345321at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="248" mass="26057" checksum="B1B28336930117F7" modified="2006-07-11" version="1">MGLIARPSRAGHVAFQTRTKESVMKALVRGALCAAALWGGAALAQAEDRPIAEPRMRSAETVEFNASGRKRADTGIYAQLGGGLEGYTGQLAPEVTPGFSYGAAVGYRPHAFFAVELGYSGGLSDIDSRMGLLDDGEGGPDIVRNAGQAVVVGSFTDTRLQPYVLTGIGLDRYNVRNDARGAIRGFSDDTSGYVPAGAGLRYQMGNLITADARVNYNFLFDQDFAPGGRAPGALDGRYSAMLSLGGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWA7</accession>
    <name>Q1CWA7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 28 kDa outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557122.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7203"/>
    <dbReference type="EnsemblBacteria" id="ABF87820">
        <property type="protein sequence ID" value="ABF87820"/>
        <property type="gene ID" value="MXAN_7203"/>
    </dbReference>
    <dbReference type="GeneID" id="41364373"/>
    <dbReference type="KEGG" id="mxa:MXAN_7203"/>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_1_0_7"/>
    <dbReference type="OMA" id="LPNGPHI"/>
    <dbReference type="OrthoDB" id="1825422at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187937" evidence="1">
        <location>
            <begin position="24"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="248" mass="26533" checksum="F82CD6C8775069C5" modified="2006-07-11" version="1">MFARPVRPLLLTAMLLTGLTAFAQPQPVSAPRAQAPAGMRTIRVEGTGEVKAQPDEAFIDVAVETLAPNAKAAGEQNAKRMEKVIAALTSAGIARRDIQTRNYSVYPEYAPPLPNQTEPKLKGYRVSNLVSVHVKDLSRVGNLLDQALAAGANRVDSVRFGLSRQEAVQGEALRQAVARARKSAEVLAASLNVKLGAVLDASTVTEPPQLYPARFAMAEVADARAMATPIQPEEQTVQAKVTLIFAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB2</accession>
    <name>Q1CWB2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M64_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7198"/>
    <dbReference type="EnsemblBacteria" id="ABF92265">
        <property type="protein sequence ID" value="ABF92265"/>
        <property type="gene ID" value="MXAN_7198"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7198"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048556_0_0_7"/>
    <dbReference type="OMA" id="CVMFTRD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032625">
        <property type="entry name" value="M64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038171">
        <property type="entry name" value="M64_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16217">
        <property type="entry name" value="M64_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M64_N" evidence="2">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="502" mass="56277" checksum="A8ACDD9DBCB29812" modified="2006-07-11" version="1">MSRQADTSSAGWERSVNTHPRATTAHRVPPMMRALFVLLLATSASAASPRTLRVDYFHTGNATEERFSLDKVVIEPLPWPGHPERAIDETNLGKYLFEVRGRENNRLLFSRGFASIYGEWEVTNEARSSNRTFHESLRFPAPERPVQVLLKKRDAQNAFREVWSLVVDPKDMFVDASSPPAPGPLLKLLENGPSAQKVDLLILGDGYTKAEHAKFEKDARHMVDILFTFSPFKERKSDFNVWGLVPAAAQSGISRPSTGVHRRSPIGATYDAFGSERYVLTFDNKAFREAAAFAPYEFVEILVNGNTYGGGGIFGLYGTVASDSLWAPYVFVHEFGHHFAGLADEYYTSESVYAPAADRLEPWEKNVTALHSPEGLKWKHLVSPGTPLPTPWNKEGYEKHATAVQKQRGHIRAQRKPESDMDKLFLAQRDWEEKFLSSQKYSGRVGAFEGAMYESKGYYRPQVDCVMFTRDRVPFCAVCQSAISEVIDLYSGPPAMSPQANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWC1</accession>
    <name>Q1CWC1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557108.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7189"/>
    <dbReference type="EnsemblBacteria" id="ABF89544">
        <property type="protein sequence ID" value="ABF89544"/>
        <property type="gene ID" value="MXAN_7189"/>
    </dbReference>
    <dbReference type="GeneID" id="41364362"/>
    <dbReference type="KEGG" id="mxa:MXAN_7189"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067099_0_0_7"/>
    <dbReference type="OMA" id="IFHPIFW"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="39088" checksum="3FFF7422F3364D07" modified="2006-07-11" version="1">MKTQVKALPLPRFYDAAHAGQFGYSPDAGKLQVEAQRWRAANDVSMSATDAFNLHLLLIDVQKDFCFPEGSLYVAGRSGRGAVDDSRRIAEFIYSNLGALTNVTATLDTHFAYQIFFPSFWVDQDDQPLTPYREVTREQIERGQARPNPAMAKWLCGGNYPWLLKQVKYYCEELERAGKYTLYLWPPHCLLGSDGHALAGVVQEARLFHSFARGMQSWAEVKGGNPLTENYSVLRPEVLGRHDGQPLAQRNTQFLKTLLTADAVVIAGQAASHCVKSSIDDLLGEIVAQDAALARKVYLLTDCMSSVTVPDGKGGFAADFTPQAEASLKRFADAGMHLVKSTDPLASWPDLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWK1</accession>
    <name>Q1CWK1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557028.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7109"/>
    <dbReference type="EnsemblBacteria" id="ABF91034">
        <property type="protein sequence ID" value="ABF91034"/>
        <property type="gene ID" value="MXAN_7109"/>
    </dbReference>
    <dbReference type="GeneID" id="41364283"/>
    <dbReference type="KEGG" id="mxa:MXAN_7109"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_2_7"/>
    <dbReference type="OMA" id="HGGPDIG"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="65"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="29812" checksum="DBC6341DEF884E54" modified="2006-07-11" version="1">MRQGLLLMMGALLLSACVQGRSREVLREPSATGAVSESEFKALHTLREDAPPAPKGQEVEVAGTKAYLSLPQGAQGPLPAVIVIHEWWGLNDHIRHWTDRLAAEGYAALAVDLYGGKVATSRDEALALLKAVDPARAQETLTAAHTFLQQDARVQAPRTGTIGWCFGGGWSLHAAMAMPELDAAVLYYGNPVTEARELAAIRAPVLGIFGTKDPSIPLETVQAFRQALDDAGVRHYILEFEAEHAFANPSSERYDAQAAAGAWQQVAAFLDQHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX04</accession>
    <name>Q1CX04_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutathione-regulated potassium-efflux system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_6954"/>
    <dbReference type="eggNOG" id="COG0475">
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="595" mass="64498" checksum="FE0F892A0CBDD4E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX10</accession>
    <name>Q1CX10_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative chemotaxis protein methyltransferase CheR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556869.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6948"/>
    <dbReference type="EnsemblBacteria" id="ABF86317">
        <property type="protein sequence ID" value="ABF86317"/>
        <property type="gene ID" value="MXAN_6948"/>
    </dbReference>
    <dbReference type="GeneID" id="41364126"/>
    <dbReference type="KEGG" id="mxa:MXAN_6948"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_4_1_7"/>
    <dbReference type="OMA" id="ETFFFRY"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="569" mass="60180" checksum="E5E75E86E9CA544F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX41</accession>
    <name>Q1CX41_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6918"/>
    <dbReference type="EnsemblBacteria" id="ABF87274">
        <property type="protein sequence ID" value="ABF87274"/>
        <property type="gene ID" value="MXAN_6918"/>
    </dbReference>
    <dbReference type="GeneID" id="41364100"/>
    <dbReference type="KEGG" id="mxa:MXAN_6918"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_2_1_7"/>
    <dbReference type="OMA" id="AQEAFYA"/>
    <dbReference type="OrthoDB" id="1765806at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="148" mass="16209" checksum="D6A783ACCE67DF47" modified="2006-07-11" version="1">MHLTLHADYSLRVLLYLATRTGRPVSTQEMADAYGISKHHLVRVVQTLAGQGVVDARAGRSGGVVLARAPADIQVGSVLRAAEPDFHLVECFDRERNACPIAPACGLKGVLDEAREAFLAVLDRYTLADLLRRSRPNLQDYFLPTSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA7</accession>
    <name>Q1CXA7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556774.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CXA7"/>
    <dbReference type="STRING" id="246197.MXAN_6849"/>
    <dbReference type="EnsemblBacteria" id="ABF91600">
        <property type="protein sequence ID" value="ABF91600"/>
        <property type="gene ID" value="MXAN_6849"/>
    </dbReference>
    <dbReference type="GeneID" id="41364038"/>
    <dbReference type="KEGG" id="mxa:MXAN_6849"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_0_7"/>
    <dbReference type="OMA" id="RVIAGWD"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="11269" checksum="FCF51887B7FBF486" modified="2006-07-11" version="1">MGLNVEDVKVGTGTEATAGKSVTVHYVGTLTSGSKFDSSRDRGQGFTFRLGAGQVIEGWDKGVAGMKVGGVRKLTIPPEMGYGARGFPPVIPPNSTLLFEVELLDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXF5</accession>
    <name>Q1CXF5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6801"/>
    <dbReference type="EnsemblBacteria" id="ABF88680">
        <property type="protein sequence ID" value="ABF88680"/>
        <property type="gene ID" value="MXAN_6801"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6801"/>
    <dbReference type="HOGENOM" id="CLU_2899469_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="62" mass="6808" checksum="5D2F38EEC0263B60" modified="2006-07-11" version="1">MGVHPGSLGTVSEGVIRAGVKMRRWSSCRAHAWAHVAVTAARARALRARMDVITSHQPHRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL7</accession>
    <name>Q1CXL7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6739"/>
    <dbReference type="EnsemblBacteria" id="ABF88207">
        <property type="protein sequence ID" value="ABF88207"/>
        <property type="gene ID" value="MXAN_6739"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6739"/>
    <dbReference type="HOGENOM" id="CLU_524599_0_0_7"/>
    <dbReference type="OMA" id="FACSRAC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="519" mass="49991" checksum="286A4E144642BB1F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXP5</accession>
    <name>Q1CXP5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556636.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6711"/>
    <dbReference type="EnsemblBacteria" id="ABF90608">
        <property type="protein sequence ID" value="ABF90608"/>
        <property type="gene ID" value="MXAN_6711"/>
    </dbReference>
    <dbReference type="GeneID" id="41363904"/>
    <dbReference type="KEGG" id="mxa:MXAN_6711"/>
    <dbReference type="HOGENOM" id="CLU_468362_0_0_7"/>
    <dbReference type="OMA" id="VEVDWME"/>
    <dbReference type="OrthoDB" id="173604at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187886" evidence="1">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="581" mass="62702" checksum="4D43F1B8F149FDFF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ5</accession>
    <name>Q1CXQ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556626.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6701"/>
    <dbReference type="EnsemblBacteria" id="ABF93017">
        <property type="protein sequence ID" value="ABF93017"/>
        <property type="gene ID" value="MXAN_6701"/>
    </dbReference>
    <dbReference type="GeneID" id="41363894"/>
    <dbReference type="KEGG" id="mxa:MXAN_6701"/>
    <dbReference type="eggNOG" id="COG0854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104057_0_0_7"/>
    <dbReference type="OMA" id="PMSFVQA"/>
    <dbReference type="OrthoDB" id="1115365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="21610" checksum="02DD36DE5727840E" modified="2006-07-11" version="1">MLSGRPPASSYVLIDAENIDWAVSNVVGRKPESQDRVQFDRLVSFCETNFPAPVRCVVVLNARGEQLPDVMIGFVRALKSAGCDVALLYGRPDQKVVDLGILKLLENIRTQRPGAAVVLASHDGADFADALKPMLEEKRQVAVLGLREYVSQRFRELVPSGLKILDLELNAKVFNRPLPRMLPVNVDEFDPGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY7</accession>
    <name>Q1CXY7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556544.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6618"/>
    <dbReference type="EnsemblBacteria" id="ABF91867">
        <property type="protein sequence ID" value="ABF91867"/>
        <property type="gene ID" value="MXAN_6618"/>
    </dbReference>
    <dbReference type="GeneID" id="41363816"/>
    <dbReference type="KEGG" id="mxa:MXAN_6618"/>
    <dbReference type="eggNOG" id="ENOG5032P99">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899614_0_0_7"/>
    <dbReference type="OMA" id="FARDCEH"/>
    <dbReference type="OrthoDB" id="839901at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046181">
        <property type="entry name" value="DUF6209"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19714">
        <property type="entry name" value="DUF6209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188162" evidence="1">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="33935" checksum="F756762AC2AFBB0B" modified="2006-07-11" version="1">METPVWKSLTLALPLMAACGGAPQQQEETSANAMELQQAPLTAPTATVRFLNGWTHSQHGAIVRGGTLVVDYDLYRMTDCHHSTYAGQQAWDTLAYVRFLPSGQLFSGSVKQATGSTSFVNKPFEVTVPSDATSVETWFFTSGRTCAPKYDSNYGQNYVFPVEAQSPSAVVWAGDWGGSFARDCEHRDGLADPIVIDSYVMERACKFVDADVYVPGVTDAATARPELIQAQVEFSVDGAATQHRWLAYQGRVGNNYRYRWNLAAEPLAYTPWNAYAFGFRYSTDGVSWYRIASGAGPTGGTARTVQRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY47</accession>
    <name>Q1CY47_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556484.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6554"/>
    <dbReference type="EnsemblBacteria" id="ABF88537">
        <property type="protein sequence ID" value="ABF88537"/>
        <property type="gene ID" value="MXAN_6554"/>
    </dbReference>
    <dbReference type="GeneID" id="41363759"/>
    <dbReference type="KEGG" id="mxa:MXAN_6554"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_7"/>
    <dbReference type="OMA" id="PRHTVYD"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="35511" checksum="153AED885927BE1B" modified="2006-07-11" version="1">MSAPLLEATELLRTVPVGGFLSRSRRTLLNRVSFTLERGEIVALVGESGSGKSTLARVLARLDTPDAGSLRLGGEDVLTLERGGASLAYRGRVQMVFQDPFASLNPVHTVAHHLERPLLRHGRATRAGLEDRVHALLESVGLTPAEQLAQRYPHELSGGQRQRVAVARALAVEPDVIIADEPTSMLDVSTRRGVLQLLRGLTRERGIGILFITHDLASARHMADRVLVLYAGSVVESGRTADVLAAPRHPYTRLLLSAVPDGADFLNTPLPVRPATGPMPVFGCPFAPRCPHADARCHDTLPPAHVHGAAHTVRCHLESSKGASDNAAVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYA2</accession>
    <name>Q1CYA2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556429.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6498"/>
    <dbReference type="EnsemblBacteria" id="ABF92237">
        <property type="protein sequence ID" value="ABF92237"/>
        <property type="gene ID" value="MXAN_6498"/>
    </dbReference>
    <dbReference type="GeneID" id="41363706"/>
    <dbReference type="KEGG" id="mxa:MXAN_6498"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_2_7"/>
    <dbReference type="OMA" id="PADWTAF"/>
    <dbReference type="OrthoDB" id="1818437at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19652" checksum="FE113746F42E2810" modified="2006-07-11" version="1">MTTPRILAISGSLRTGSFNRQLLAIAVAHARSLGAEVDVVDLKTLELPLYDGDVEAKALPAPVEELRERLGKAQGLLIASPEYNSSIPGGLKNAIDWVSRPPGRLFQEKWVAMMGATPGVFGTARMQPHLRQVMASVGAHVLPTQVHMARVSDAFTPDGKLKDEARQKEVEGLAAALVSKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYD7</accession>
    <name>Q1CYD7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ORF">MXAN_6463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556394.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6463"/>
    <dbReference type="CAZy" id="GH77">
        <property type="family name" value="Glycoside Hydrolase Family 77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89895">
        <property type="protein sequence ID" value="ABF89895"/>
        <property type="gene ID" value="MXAN_6463"/>
    </dbReference>
    <dbReference type="GeneID" id="41363669"/>
    <dbReference type="KEGG" id="mxa:MXAN_6463"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_7"/>
    <dbReference type="OMA" id="QYPNWRL"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="516" mass="59075" checksum="89C56E816DDF9AD7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ83</accession>
    <name>Q1CZ83_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556103.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6159"/>
    <dbReference type="EnsemblBacteria" id="ABF86115">
        <property type="protein sequence ID" value="ABF86115"/>
        <property type="gene ID" value="MXAN_6159"/>
    </dbReference>
    <dbReference type="GeneID" id="41363388"/>
    <dbReference type="KEGG" id="mxa:MXAN_6159"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_7"/>
    <dbReference type="OMA" id="TEYTDAD"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27590" checksum="3F0482FC9A44FDC5" modified="2006-07-11" version="1">MSARFANQKLIVVGGTSGMGKAVARILLEEGGRAVVIGHRDDKLQAAVAELAASGPVEGLRADIASGTERQALVAQLQKDHADATLLVNAAGVFLPKAFLEHEERDYDLYLDINKALFFITQAVARSMVALRKGGAIVNIGSMWAKQAIQATPSSAYSMAKAGLHSLTQHLAMELAGHGIRVNAVSPAVVETPIYEGFIPKEQVHGALQGFNGFHPLGRVGRAEDVAQTIVHLLSDETSWVTGAIWDVDGGVMAGRNKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ89</accession>
    <name>Q1CZ89_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trigger factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6153"/>
    <dbReference type="EnsemblBacteria" id="ABF87867">
        <property type="protein sequence ID" value="ABF87867"/>
        <property type="gene ID" value="MXAN_6153"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6153"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760139_0_0_7"/>
    <dbReference type="OMA" id="VEHVMNK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_C" evidence="6">
        <location>
            <begin position="222"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="44154" checksum="A862CBA6B218F1F2" modified="2006-07-11" version="1">MSERLGWTMPWSMPSRRFSPHWRGRWQAYLPGAFVSRKQGTQGPGHGVERLLKMSPVVSLGSARALELPTVQAPSLEGVSVRVPTPDDLTEEDLLRAFHEKRRALATSRERQPGESLELGDEVRLNIVGYCDGKLIPFSARFGMTTELAPIEALPGFSEAVAEGAKVGESLQIALELPETYPVEALQGKPARFLVDVLAAHEVTLPSESAPEFLEKLGLGSTLGEMMTHLRDELEDAAAAQLWVQARDMVLDELVRRAPVELPRALVDEELRRRWVQAEGQGMLEHQFDVDEQREALQGWLTDPTTRADVERRLHIGIVLKAITEEQKLQLTPEKLEQLVRDQLEPFGLTAADAHAALRESPETTKQLAEMGWYLLAVEHVMNKAKVTFEGSEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB1</accession>
    <name>Q1CZB1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556075.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92998">
        <property type="protein sequence ID" value="ABF92998"/>
        <property type="gene ID" value="MXAN_6128"/>
    </dbReference>
    <dbReference type="GeneID" id="41363361"/>
    <dbReference type="KEGG" id="mxa:MXAN_6128"/>
    <dbReference type="HOGENOM" id="CLU_2024239_0_0_7"/>
    <dbReference type="OMA" id="WMGRTSI"/>
    <dbReference type="OrthoDB" id="1739752at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13499" checksum="170FF212FE0FC358" modified="2006-07-11" version="1">MRKVSTPTLLLSICAVGIIIALGATWWMGRTSILVVNASERELRSLEVKFPGRTCRYENVAPQAEVRCEGRADGDGYVEVSYRFDEGAELGVFSTKYVNPTLGWRGSMLLRPDGTIDATRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB9</accession>
    <name>Q1CZB9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556068.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86290">
        <property type="protein sequence ID" value="ABF86290"/>
        <property type="gene ID" value="MXAN_6119"/>
    </dbReference>
    <dbReference type="GeneID" id="41363353"/>
    <dbReference type="KEGG" id="mxa:MXAN_6119"/>
    <dbReference type="HOGENOM" id="CLU_153840_0_0_7"/>
    <dbReference type="OMA" id="WIESIIM"/>
    <dbReference type="OrthoDB" id="1654414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="13689" checksum="7459F4B8D9B91188" modified="2006-07-11" version="1">MWIESIIMPREDDSEPYVPAPQRDRRSGLAAALEESRKLRDRVQRFVSAHDLSDGVRWLSEPGLLPVITIHCTDFALAKLREAADFVVGCAAPIDVYPALVGTQGQVAPEALLTSAVSHLQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZI6</accession>
    <name>Q1CZI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556001.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90744">
        <property type="protein sequence ID" value="ABF90744"/>
        <property type="gene ID" value="MXAN_6052"/>
    </dbReference>
    <dbReference type="GeneID" id="41363290"/>
    <dbReference type="KEGG" id="mxa:MXAN_6052"/>
    <dbReference type="HOGENOM" id="CLU_562384_0_0_7"/>
    <dbReference type="OMA" id="LAMSIPH"/>
    <dbReference type="OrthoDB" id="1736106at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188069" evidence="2">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="52819" checksum="66E625B8F57F7B34" modified="2006-07-11" version="1">MKRVVLGLFAAVVLHACAAHEKTGDRAAAVGDWKAAYASYRQALTSEPDSPEIKLKFDTARTKALQDAQQRAQTCAQVNDWGCALAESDFALSVEPGNAEIASFRANAAQQVAMGQLDTAVQQAQQGQYAEAASLMDRALQLSPAPEVRTHAEDVRRIITTQGRAQADRYLHEGNFIAAHELAQLVLSLDASASAWAQNIAAEYEHFITEEVERLSREGDAARAQRDWGRAQQSYGAALSLRQGGRAAPLEAYVRHMALADQRIAGRDWNGAADAYHVALRTGQDDGYANHQLERVQLRPYRVVLRSVLVTPGRPDGRAWVGASNDIFTRLANRLTQTARQRGMTDLVKDLAMSIPHENRPRLRIEVHHPDGMHLTTQGRDGIYTAYDAEFVAVANAFDDRRVGFQVYMDGPNGSELLGSVDVPMRELVEHREVSLEGRSVIALMLSTGGDGRQPGPYAGMAHVLPPPPPGTPPPGRGHAATPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ3</accession>
    <name>Q1CZQ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555934.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88695">
        <property type="protein sequence ID" value="ABF88695"/>
        <property type="gene ID" value="MXAN_5985"/>
    </dbReference>
    <dbReference type="GeneID" id="41363224"/>
    <dbReference type="KEGG" id="mxa:MXAN_5985"/>
    <dbReference type="HOGENOM" id="CLU_1617240_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17611" checksum="3D1E614EFCD6E72D" modified="2006-07-11" version="1">MTLLPRPVVHGAGRVPIPGGIGGVVARHAGTRDTVGDLDSTLQARGYEAPAPLAATDEEQDRLASAIVLQSSAFDLKERNHTDAYSLLQESLVRLEQAAGAQDPYLVPQLVELARLHVQHDAPEAARRMLQRAIDIVQAQPGHEPQQVDALNEMLSEIPVPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZT7</accession>
    <name>Q1CZT7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5949"/>
    <dbReference type="EnsemblBacteria" id="ABF91235">
        <property type="protein sequence ID" value="ABF91235"/>
        <property type="gene ID" value="MXAN_5949"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5949"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_2_1_7"/>
    <dbReference type="OMA" id="EFYLAHR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="76"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="35176" checksum="4FD4F6E3F1588881" modified="2006-07-11" version="1">MKPADALARWGDGTALLHPPAVHAFQVLGTFTDASDVLARLASPPFCPGYVSQRIEFQQGVRVVALETPTLPPAAHTNAYVLGNGELLIVDPGAADVKQYAKLLSLVSGLKAEGLRPVAVVLTHHHGDHVGGARAVKERLGIPLWCHARTADRLDFPAERLLEDGDVLELAGEVPQRWRVLHTPGHAQGHVCLVDERSRSAVVGDMVAGVGTIVIDPPEGHMRDYLTQLARLRDWPVSTLYPAHGSPIPDGPAKLQEYLDHRAAREALILQSVPPNGATLAQVVSLAYADTPPLLHPLAERSALATLEKLVEEGLVREESLQYFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0M2</accession>
    <name>Q1D0M2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">batA</name>
        <name evidence="3" type="ORF">MXAN_5663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555616.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5663"/>
    <dbReference type="EnsemblBacteria" id="ABF91605">
        <property type="protein sequence ID" value="ABF91605"/>
        <property type="gene ID" value="MXAN_5663"/>
    </dbReference>
    <dbReference type="GeneID" id="41362908"/>
    <dbReference type="KEGG" id="mxa:MXAN_5663"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024570_0_0_7"/>
    <dbReference type="OMA" id="RYFRATD"/>
    <dbReference type="OrthoDB" id="736429at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01467">
        <property type="entry name" value="vWA_BatA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033881">
        <property type="entry name" value="vWA_BatA_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="93"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="37002" checksum="551EB53458C5EA19" modified="2006-07-11" version="1">MPPLPAFNNPEALWGLLLVPLLLWQAWRERRARATLRFSAAHVFARGGRGFRAYLLPLLPLLRVAAVTAAVLAIARPQVRDSRVRDLSVEGIDIVVALDLSTSMEAGDFRPQNRMHVAKEVLSEFIANRVNDRIGLVVFAGAAYTQAPLTLDYGVLKEVVKQLRTRVLEDGTAIGDALATSLNRLRDSEAKSRVVVLITDGDNNSGKISPMDSANMAQALKVPIYTILVGKGGKVPFPQGTDLFGNTVWRDTEIPINPELMQDIADRTGGEYYRATDPEQLREGLQKVLDSLERSKLMEGGASATYREEFHPFLLAAFGLAALELLLRASFLRVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Y7</accession>
    <name>Q1D0Y7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555501.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5547"/>
    <dbReference type="EnsemblBacteria" id="ABF88298">
        <property type="protein sequence ID" value="ABF88298"/>
        <property type="gene ID" value="MXAN_5547"/>
    </dbReference>
    <dbReference type="GeneID" id="41362795"/>
    <dbReference type="KEGG" id="mxa:MXAN_5547"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_7"/>
    <dbReference type="OMA" id="WIGPAQE"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="207" mass="23143" checksum="AB608B865864634C" modified="2006-07-11" version="1">MERKRRSATGEQSRRAILDAALDCFSRLGWAATTIEDIRKVSGASVGSVYHHFGAKEGIAVALYIDCLRLHQESLRGRLERKHDAEAFVRTIVTHHIAWSREHPEAARYLLRMRREEAVAAAEQEIQSATGDFIREGFSRMKAHAQAGELLPLPPAVYMPLMLGPAQELLRAWANGQVELKAGIEKVLADAAWRCLRPETAPSRKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D100</accession>
    <name>Q1D100_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4476 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555488.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5530"/>
    <dbReference type="EnsemblBacteria" id="ABF89441">
        <property type="protein sequence ID" value="ABF89441"/>
        <property type="gene ID" value="MXAN_5530"/>
    </dbReference>
    <dbReference type="GeneID" id="41362783"/>
    <dbReference type="KEGG" id="mxa:MXAN_5530"/>
    <dbReference type="HOGENOM" id="CLU_1155446_0_0_7"/>
    <dbReference type="OMA" id="FAEDKMR"/>
    <dbReference type="OrthoDB" id="1796532at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028011">
        <property type="entry name" value="DUF4476"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14771">
        <property type="entry name" value="DUF4476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188001" description="DUF4476 domain-containing protein" evidence="3">
        <location>
            <begin position="40"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4476" evidence="4">
        <location>
            <begin position="148"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="27456" checksum="74EA803EFA508CFD" modified="2006-07-11" version="1">MEPAPARQMLRAHERTLPMKALITSLALLFALPSLDAHAQAEMRRPPSPPPGQQMPQPHHPHQPNYPPQHSGSQVVVDRRELNERLDRLEKLLKEAEQRMNRQERNKFRNAKETLNSVQDLVNRAPLLATVLPPPAPMPPPQPVVRPISDSELRRIHSSISLQTFAEDKMRVLVSAAQHHYFLVSQVGQLLGNFQFTQDKLAVVRELKPYILDPQNSHTLYSHFSFSSDKKRLDDILSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B0</accession>
    <name>Q1D1B0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555378.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91860">
        <property type="protein sequence ID" value="ABF91860"/>
        <property type="gene ID" value="MXAN_5416"/>
    </dbReference>
    <dbReference type="GeneID" id="41362678"/>
    <dbReference type="KEGG" id="mxa:MXAN_5416"/>
    <dbReference type="eggNOG" id="ENOG502Z7UH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896243_0_0_7"/>
    <dbReference type="OMA" id="AYRWQYI"/>
    <dbReference type="OrthoDB" id="787360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="35094" checksum="B85F4CAB78EE55B1" modified="2006-07-11" version="1">MPNQTPEYQSCIQSSEKVSWRLDDLLPKDTVLDFSHRFLSDALTGAEAIPFLNAEERLMLNHIRSNSYAHLFLFLEEYAVALAAQRASLELHGNATHMRALLRFTEEELKHQQLFARFTGAFARGFKVVPALLDNHVEVARAIMAKSNLGVLIFNLHLELMTQQHYLETVRGNNAETLDPLFCNLLKHHWLEEAQHTRLDFLEAQKILAREPDTLDEALTEYAELLQALRGTLNAQLALDLQTLEKAVGRTFTPEEHKHLAESQERSYVWGFIGMGMKAPLFLSRLRALSPIAEQRILELAPTYYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1M5</accession>
    <name>Q1D1M5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5297"/>
    <dbReference type="EnsemblBacteria" id="ABF86862">
        <property type="protein sequence ID" value="ABF86862"/>
        <property type="gene ID" value="MXAN_5297"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5297"/>
    <dbReference type="HOGENOM" id="CLU_808513_0_0_7"/>
    <dbReference type="OMA" id="ENSACAF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="36330" checksum="622E76B2C7EBD73E" modified="2006-07-11" version="1">MSGGCTESKVAEDQDIVLSGRLVDEAGAPLSDALLKLYRSENSACAFAAFSSSWRSVKTRVDGTFEVDLLGADTRNGSIARCFVARSPEQSQGRRVSAFFLIQQSEVALPVIQEWTGTMTATAQAQGVSVGFRPLSATHGAGNNEHVLSLHPSSAREAWQVLKATSPVLLSDYVLEDAEGLKASIITTRDVNAGGVTVGLTYTSDDVVLPRRALVPASRGAACTYLNAETPCRVTNGDLGGIVLFQEGVREVAVQLSRPVVPRKAVLRNFGVTGTMSELVLEGSADGAQWMPLANLLDGASVQSFMEVDLTGTTPVSQVRVRATPQESVGALRSLGQLSLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1N0</accession>
    <name>Q1D1N0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Biosynthetic peptidoglycan transglycosylase</fullName>
            <ecNumber evidence="11">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycan polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peptidoglycan glycosyltransferase MtgA</fullName>
            <shortName evidence="11">PGT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">mtgA</name>
        <name evidence="14" type="ORF">MXAN_5291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555258.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5291"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91258">
        <property type="protein sequence ID" value="ABF91258"/>
        <property type="gene ID" value="MXAN_5291"/>
    </dbReference>
    <dbReference type="GeneID" id="41362564"/>
    <dbReference type="KEGG" id="mxa:MXAN_5291"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_1_0_7"/>
    <dbReference type="OMA" id="WDGIQKA"/>
    <dbReference type="OrthoDB" id="1793788at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00766">
        <property type="entry name" value="PGT_MtgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011812">
        <property type="entry name" value="Pep_trsgly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02070">
        <property type="entry name" value="mono_pep_trsgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Transgly" evidence="13">
        <location>
            <begin position="90"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF91258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="33143" checksum="F1B9C81423BF5285" modified="2006-07-11" version="1">MASRPPSVRASSPRTQKTKQLPAGARRAVRKDSSPGWGRWMFGGWLLFVVWLSVEYVRLPDVRALQTQNPRTTALITQRAEEALAEGKKPRVRQAWVPLEAVAPHALDAVLSSEDARFYKHEGVDWIEVENALEQSVRKARLGRGASTLTQQLAKNLYLSTDRSLLRKGKELLLARQLETHLSKQHILTLYVNVVEWGEGVYGIEAAAREHFGTSARALSVAQGAMLAGMLPAPRRWLPAQKPETLRIRAGAIIGRLQREGRITATQAREAQAELSRFFGETSVPGSVVEAISRLSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X2</accession>
    <name>Q1D1X2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ansA</name>
        <name evidence="8" type="ORF">MXAN_5198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555169.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D1X2"/>
    <dbReference type="STRING" id="246197.MXAN_5198"/>
    <dbReference type="EnsemblBacteria" id="ABF90196">
        <property type="protein sequence ID" value="ABF90196"/>
        <property type="gene ID" value="MXAN_5198"/>
    </dbReference>
    <dbReference type="GeneID" id="41362480"/>
    <dbReference type="KEGG" id="mxa:MXAN_5198"/>
    <dbReference type="eggNOG" id="COG0252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_3_7"/>
    <dbReference type="OMA" id="AIVPKLM"/>
    <dbReference type="OrthoDB" id="1659551at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="7">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="353" mass="37785" checksum="F8D43E57E0785676" modified="2006-07-11" version="1">MPRVLLLHTGGTLGMAGGRPSALKPAAFFKTLKARVPELFELADIELELFSNLDSSEMQPELWSRMAAHLHARLPHFDGAVVTHGTDTLAYTASALSFMLRNPPCPVVLTGSQRPLGKIRSDARLNLIDAVLSALHGPREVTICFDSRLYRGNRARKVKVSEYDAFDSPNFPVLGTLGVDTTFEPGLKSRGAFRLYERLDAKVFLLKVYPGLDPALPLQLLPHVRGLVLEAYGAGNFPIAPELGRSLTPLFLQARERGVPVVVVSQAHRNGVDLSLYESGAAALEAGAMGGADMTPSAALVKLMQGLAYHSGSSGALARYIQTPVAGELTVGRPTVAPEAPAGPPATRRPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D239</accession>
    <name>Q1D239_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555103.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5130"/>
    <dbReference type="EnsemblBacteria" id="ABF87895">
        <property type="protein sequence ID" value="ABF87895"/>
        <property type="gene ID" value="MXAN_5130"/>
    </dbReference>
    <dbReference type="GeneID" id="41362414"/>
    <dbReference type="KEGG" id="mxa:MXAN_5130"/>
    <dbReference type="eggNOG" id="ENOG502ZSCK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093748_1_0_7"/>
    <dbReference type="OMA" id="YELSTCD"/>
    <dbReference type="OrthoDB" id="1368875at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="198" mass="21803" checksum="3C5174A81D71E220" modified="2006-07-11" version="1">MAAHGSLRASLLAALLLAAREARPEPAHEASPWYVPDHAAMQFAGAIGFLSAGPGWSFLDDTVEAALLVGWAPPALAGEDFFTFTLKGQWRPFLLDAAEWTVRPLMVGAMLSYTVGDDYFAGLPSRYDRGYYWFRTAVRPALLLGASAGRPVEALNLRFVEGYFELVATDYRLVQFIRNPTTVNVELFTLALGVKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D262</accession>
    <name>Q1D262_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">argH</name>
        <name evidence="6" type="ORF">MXAN_5107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555081.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5107"/>
    <dbReference type="EnsemblBacteria" id="ABF92783">
        <property type="protein sequence ID" value="ABF92783"/>
        <property type="gene ID" value="MXAN_5107"/>
    </dbReference>
    <dbReference type="GeneID" id="41362391"/>
    <dbReference type="KEGG" id="mxa:MXAN_5107"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_7"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="5">
        <location>
            <begin position="35"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="449" mass="48466" checksum="5CDBFDE234DCB25B" modified="2006-07-11" version="1">MADTLWGKGLPLDAAIHRFTVGNDPVVDLALAPHDALGSAAHARMLARVGLLKDAEAKSLVTALKALHDEARAGTFVIRPEQEDGHTALEAALVERVGEPGKRIHLGRSRNDQVQLALRLLLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRRAMPSTFGLWGMAFAEGLLEELEALRGVWARLDRCPLGAAAGFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAVLGWACSVAGTLEKWLWDVQLYSMDEFGFLGLPDAYTTGSSIMPQKKNPDVVELARGRCRELRGLAHQVEAVAGGLPSSYHRDFQLLKSPTLTALGSTRELLDVLTRLVPALQVKADAAARASDDTLYAAHHAYALVAQGQAFRDAYKQVGRELVEGTFRPDRGALTATHLGGAGNLGLPQAREELAASRAWLDETHRLVADAAGRVWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R8</accession>
    <name>Q1D2R8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554879.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4898"/>
    <dbReference type="EnsemblBacteria" id="ABF85975">
        <property type="protein sequence ID" value="ABF85975"/>
        <property type="gene ID" value="MXAN_4898"/>
    </dbReference>
    <dbReference type="GeneID" id="41362188"/>
    <dbReference type="KEGG" id="mxa:MXAN_4898"/>
    <dbReference type="eggNOG" id="ENOG5032K7K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064716_0_0_7"/>
    <dbReference type="OMA" id="FANPHAD"/>
    <dbReference type="OrthoDB" id="2120393at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="365" mass="39324" checksum="9F247E985A4B350F" modified="2006-07-11" version="1">MTQDSGFWPNVRLVWGVVKHTAPFHCPRLMLLMVAILAAACRSTPFQVRGAVPESLGASAVVVQPFGFQWAEPDWRSVELSQRLVNVALAQTGDAALFFGPTELQVARPGEDGGNGLTRAVVATLASYGVRPDGLMVLRPSAEKRIQSGERELIDTEGYTVGQSATEVVMYVGRVEVLHPATHEVVLEVFGEATVNPYADILDEGADPAPELTSLMEALTREALRGLSSHLKPPRAPSPALATSLAWAPWDVLDMAAWMPKDMTDLEAPLRTEAGQDPRSLRMQRLRFANPHADAALLETLARRPGGLYVRAAPEGAKLSAGDLVLTLDGRPALPQTLARARLALVPVEARVQQPSGRIVPLVLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D345</accession>
    <name>GLYA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="1">SHMT</shortName>
            <shortName evidence="1">Serine methylase</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyA</name>
        <name type="ordered locus">MXAN_4766</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D345"/>
    <dbReference type="SMR" id="Q1D345"/>
    <dbReference type="STRING" id="246197.MXAN_4766"/>
    <dbReference type="EnsemblBacteria" id="ABF91510">
        <property type="protein sequence ID" value="ABF91510"/>
        <property type="gene ID" value="MXAN_4766"/>
    </dbReference>
    <dbReference type="GeneID" id="41362065"/>
    <dbReference type="KEGG" id="mxa:MXAN_4766"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_7"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000006282" description="Serine hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <sequence length="418" mass="44654" checksum="659A4DBD3B91B582" modified="2006-07-11" version="1">MENIRTLAEVDPEIARVLREETQRQEEGLELIASENFVSPAVMEAVGSVLTNKYAEGYPGKRYYGGCEVVDVAENLAIARAKDLFGADAVNVQAHSGSQANMGAFMALMKPGDTMLSLDLNSGGHLTHGATFNFSGKLYKVVHYGLTRDTETIDFAQVESLAKEHKPKVIVVGASAYPRTLDFAKFREIADAVGAAMLVDMAHIAGLVAAGVHPSPVPVADIVTSTTHKTLRGPRGGLVLSREPYAKAINSQIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQRQIVANAKALAEALQRAGLRLTSGGTDNHLMLVDLRPKKLTGKVAEEVLDKAGITVNKNMIPFDPEKPMTTSGVRVGTPAITTRGMREAEMAVVGRLIGEALDAAQDDAALARIKGQVKELSQGFPLYASRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D354</accession>
    <name>Q1D354_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554744.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4757"/>
    <dbReference type="EnsemblBacteria" id="ABF90229">
        <property type="protein sequence ID" value="ABF90229"/>
        <property type="gene ID" value="MXAN_4757"/>
    </dbReference>
    <dbReference type="GeneID" id="41362056"/>
    <dbReference type="KEGG" id="mxa:MXAN_4757"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_7"/>
    <dbReference type="OMA" id="MPQYVEG"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20410" checksum="EC5286803C4B8CD7" modified="2006-07-11" version="1">MSRFSELLDDFFYRPDEDVSGLQDFAAGSDGVLPSAPEEVPEEYLAFRLEGECYAVPIRGVREISKVPPLTEIPRAEPQLLGVMNLRGELLPVYDVKVRLRLAERAPLVAGPDAPAPPRSARILVLRTETGPAGVWVDGVVGVVKLKPSMLEAPPPGLRVGDRDCVVGMGRRGPMLYILLDAEQALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K4</accession>
    <name>Q1D3K4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554596.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4601"/>
    <dbReference type="EnsemblBacteria" id="ABF86447">
        <property type="protein sequence ID" value="ABF86447"/>
        <property type="gene ID" value="MXAN_4601"/>
    </dbReference>
    <dbReference type="GeneID" id="41361901"/>
    <dbReference type="KEGG" id="mxa:MXAN_4601"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_225225_0_0_7"/>
    <dbReference type="OMA" id="RIAQWAP"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
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        <property type="entry name" value="FAAL/FAAC"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="596"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1662"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2723"/>
            <end position="2798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1645"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3256"/>
            <end position="3292"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1697"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="3292" mass="361671" checksum="DC7ABDB71BBB15E5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3S2</accession>
    <name>Q1D3S2_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4533"/>
    <dbReference type="EnsemblBacteria" id="ABF90538">
        <property type="protein sequence ID" value="ABF90538"/>
        <property type="gene ID" value="MXAN_4533"/>
    </dbReference>
    <dbReference type="GeneID" id="41361835"/>
    <dbReference type="KEGG" id="mxa:MXAN_4533"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_7"/>
    <dbReference type="OMA" id="LWQMMLL"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="259"/>
        </location>
    </feature>
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        <location>
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            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="47783" checksum="2CD712431346423D" modified="2006-07-11" version="1">MAFSSRNVVTNPARVFSLIWLGQLISSLGTGLTQFSVGVYVYQNSDSVTEYSLASFFGFLPMVLLAPVAGSMVDRSNRQRVMLLADLGAMTAIGLMWCFVAADRAGLWPLQNWHFYPPLAMSAAFSTFRVLAFSTATPLLVSKQNLGRANGMVELAMSAGQLLGPAMAGVLVVRMGLQGVLLIDLATFLFAVATLLSVRIPQPEPDAARTEPRKSLWTDIALGWRFIRERPGLLGLLGFSSAVNLITVLVTVLITPLVLSFTDPTTLGLVVSCSGVGMVAGGITMGVWGGPKRRILGVLGAELVAGVALLAAALPASVFVVACAAFVFMFTAPVAMGCSQAIWQSKVPPAIQGRVFATRRMLALVAPPVAALLAGPLTDKVFDPWMAPDGALANTFGQVLGTGPGRGIALLYVVLGLLLAGCVMLTASSPRVRGVEDELPDALLPQGLPAAQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D425</accession>
    <name>Q1D425_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554426.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4427"/>
    <dbReference type="EnsemblBacteria" id="ABF93006">
        <property type="protein sequence ID" value="ABF93006"/>
        <property type="gene ID" value="MXAN_4427"/>
    </dbReference>
    <dbReference type="GeneID" id="41361739"/>
    <dbReference type="KEGG" id="mxa:MXAN_4427"/>
    <dbReference type="eggNOG" id="COG4464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085966_1_0_7"/>
    <dbReference type="OMA" id="VHPERNS"/>
    <dbReference type="OrthoDB" id="1666267at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26187" checksum="39DA7870EE384F5E" modified="2006-07-11" version="1">MSGFVDLHCHLLPGVDDGARTLEDALEMARALVDLGFSTVAPSPHARPEYAPVEVVDVRRAELAEALERERIPLALGRNAENVLDDAFLRGLSTPQARKLGPGRYVLVELPYTAPVPALPDILFRIRTKGVVPLLAHPERCLEFERKGRAAEAVRAGALLQLDIGALIGRYGGTAKKLSRAFLDDGLYAVGATDLHGPVGARDWVGRSLAELRSRAGEASFARLMRDNPATLLAGESLESDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4J2</accession>
    <name>Q1D4J2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CHASE2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554259.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4256"/>
    <dbReference type="EnsemblBacteria" id="ABF88910">
        <property type="protein sequence ID" value="ABF88910"/>
        <property type="gene ID" value="MXAN_4256"/>
    </dbReference>
    <dbReference type="GeneID" id="41361571"/>
    <dbReference type="KEGG" id="mxa:MXAN_4256"/>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574682_0_0_7"/>
    <dbReference type="OMA" id="WVIPLVP"/>
    <dbReference type="OrthoDB" id="796410at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="51133" checksum="338BA8BC3B65DEA5" modified="2006-07-11" version="1">MDSSPAEPHRRDGLRLPSPAVLRVLGACVGIALAGVTAATGGAPGFLERPLYDQAVSRLLPAVPPSADLVLVEVDDRALATLSERWPLSRTTWARAFHALAAQRPAAVAVDVVFDQPGPRDALELGEDILEALRRSGLTEQPAGEALAADLEARLLARDGDARLAEAISEGNGVVLGAAALTDDVPVMAPLQDGALGTPLALPAHALRLQAREVAGSIAPLRMAARGSGTLNMLVDGDGVIRRYPYAVGVSGQAWPSLALATALHLTPERAEPLRELAAWDHGAPLMRLPAPNWLPRVSLADLLHADPRSVGLDLALRGKTVFVGVTATGLHGQSTLPGQVAVPGVEIHAFALDNLRSGRLMRSSGLVALLGVLETAAVLAAFVWLCRRARTSGAVLRWAVTLAVLHTALVAWLASDPGWVIPLVPSWVGLLLMLVVDAASRAQEMGRQRGALRRLFIRYPQASVEPAAPQRDAQRARADAMHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4J8</accession>
    <name>Q1D4J8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554253.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4250"/>
    <dbReference type="EnsemblBacteria" id="ABF92135">
        <property type="protein sequence ID" value="ABF92135"/>
        <property type="gene ID" value="MXAN_4250"/>
    </dbReference>
    <dbReference type="GeneID" id="41361565"/>
    <dbReference type="KEGG" id="mxa:MXAN_4250"/>
    <dbReference type="eggNOG" id="COG1926">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_7"/>
    <dbReference type="OMA" id="ECPAYLI"/>
    <dbReference type="OrthoDB" id="1567476at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24490" checksum="85DDDFB22935AAA4" modified="2006-07-11" version="1">MREPEFQDRYEGGRVLADHLRRHARQPGTLVLALPRGGVPVGAEVARKLGVPLDVFLVRKLGTPGHEELAMGAIASGGVRVLNREVVNELNIGREQIEAAARREAVELQRREESYREGRPPPNVRGRTVLLVDDGLATGTTMRAAVAALRLLEPAAIIVAVPVAAAESCESLAQVADEVICVRMPEPFYSVGLWYRDFAQTEDDEVRALLAEATREGAASEAQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4P5</accession>
    <name>Q1D4P5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554206.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4203"/>
    <dbReference type="EnsemblBacteria" id="ABF92915">
        <property type="protein sequence ID" value="ABF92915"/>
        <property type="gene ID" value="MXAN_4203"/>
    </dbReference>
    <dbReference type="GeneID" id="41361520"/>
    <dbReference type="KEGG" id="mxa:MXAN_4203"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606594_0_0_7"/>
    <dbReference type="OMA" id="LTHVVTN"/>
    <dbReference type="OrthoDB" id="1128317at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="224"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="46381" checksum="9AD80E2E9D943388" modified="2006-07-11" version="1">MPESPRPLALEQMAQRVLSDASNEGEALVSGGRIVFCALILTRFLALGGAHAEGGAAAAWLQLPLLLGSIAASVMALWAARRRMFGAKLLVASTVLDAVFAHASLLSTVLWHGPHYTGLLRMPDPAAAIAVAFITALRLSPSAAWIGTAANLLLMAGLTAVDLHVNAGQSTYGAKELMLLFIFIGSAGVFASVICGIARRLVLEAGTASVHMERARTNLRALLREHHDVRTLLSAARLRADLLLREPLSASAPGHASALVEDLGELSSFIESVKARTLSELTVIEDATAVNVGATLRRAMEVVQARFARVRFELEGTAGLARAAANDVSVRIVGGERGLTHVVTNLFVNACEGDGRQGARTVRISVEPNPALHRVLLSVSDDGPGFRPGLLEGERPRAGTTKPEGAGLGMLLVSGLVEASGGTLRACNPPEGGARVEVTLPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D511</accession>
    <name>Q1D511_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4084</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria.</title>
            <authorList>
                <person name="Burgard C."/>
                <person name="Zaburannyi N."/>
                <person name="Nadmid S."/>
                <person name="Maier J."/>
                <person name="Jenke-Kodama H."/>
                <person name="Luxenburger E."/>
                <person name="Bernauer H.S."/>
                <person name="Wenzel S.C."/>
            </authorList>
            <dbReference type="PubMed" id="28128551"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX622595">
        <property type="protein sequence ID" value="APZ78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554091.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4084"/>
    <dbReference type="EnsemblBacteria" id="ABF88303">
        <property type="protein sequence ID" value="ABF88303"/>
        <property type="gene ID" value="MXAN_4084"/>
    </dbReference>
    <dbReference type="GeneID" id="41361413"/>
    <dbReference type="KEGG" id="mxa:MXAN_4084"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680979_0_0_7"/>
    <dbReference type="OMA" id="AGFQHYL"/>
    <dbReference type="OrthoDB" id="701334at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="267"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="APZ78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="42485" checksum="E537D461A4B41335" modified="2006-07-11" version="1">MSRSEAEMSLEGPRAAVPGEGAFHGLLTQPSSEVAAQLYEELGSSQRERLQKEAAQAAVAERQRLAEVLRQARDFSGAARLLDGCGAAGLVAELYVQGGRYVDAAEAYLRAGEVERAAAAFERGGAMERALEAYRGLGAREAMAHCLVRLGRPYEAAQLYRELGQPHAEVEALASVPSGDPRHLESVLRMCKLLDGEGFTRRALALLADTVRGTESARGDPALAAEKARLLRRLGMDAEAEAVIARLPSNAAAPEANGYHYLKAIPIFGELSLDDMKDLYRVARQVLIPAGGVLLEKGSPGSGLFVLLEGEVDVFSGPETDARRLNTLGPGAYLGEISLVQDAPVSAHVRARTAVRALRVTRAGFQHYLDTHDAAALRIFRLFTHNLAARVRALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D555</accession>
    <name>Q1D555_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">accA</name>
        <name evidence="12" type="ORF">MXAN_4039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554047.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4039"/>
    <dbReference type="EnsemblBacteria" id="ABF90150">
        <property type="protein sequence ID" value="ABF90150"/>
        <property type="gene ID" value="MXAN_4039"/>
    </dbReference>
    <dbReference type="GeneID" id="41361370"/>
    <dbReference type="KEGG" id="mxa:MXAN_4039"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_7"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="35544" checksum="FA6D8A24DB935F71" modified="2006-07-11" version="1">MATGTSYVLEFERPLIELEKKIDELKVLSTSGTVDFSSEISKLEKKAKKLQTEIFSDLTRWQVVQMSRHPNRPYFLDYVHYLFTDFVELCGDRAFGEDPSIVGGFARFDGKPVMVMGHQKGRNTKENMARNFGMPRPEGYRKARRLMELAERFEKPILTFVDTPGAYPGIGAEERGQAEAIAVNLEVMSRLRVPIISTVVGEGGSGGALAIGVGNRVLMLQNSVYSVISPEGCASILFRDAAKADKAADAMRLTAKDLLEMKIIDEAIAEPAGGAHRDPAKMAEALGKTLRKHLGQLAELSPDELVQDRYAKFRALGVFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D556</accession>
    <name>Q1D556_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hisC</name>
        <name evidence="8" type="ORF">MXAN_4038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554046.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4038"/>
    <dbReference type="EnsemblBacteria" id="ABF90946">
        <property type="protein sequence ID" value="ABF90946"/>
        <property type="gene ID" value="MXAN_4038"/>
    </dbReference>
    <dbReference type="GeneID" id="41361369"/>
    <dbReference type="KEGG" id="mxa:MXAN_4038"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_3_7"/>
    <dbReference type="OMA" id="YPDMACT"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="7">
        <location>
            <begin position="32"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="40037" checksum="465D754BF28832AE" modified="2006-07-11" version="1">MRPLVPTHVETLKPYVPGKPIEETEREFGLKGVIKLASNENPLGPSPRAVEAMRNVSGATHLYPDATSFHLVRKLAAHVDVKPEQVVLGSGSNELIELLIRTFTTPEDEILLCQGSFSAYRISAQAHGRPFVEMPMREGFLYDLEAMAKAITPRTRMVFLANPDNPTGTAFSRDALTRFLAAVPPEVLVVHDEAYCEFVEWPEYTSAVPLVGQHPNLVALRTFSKIHGLAGVRLGYGIMDARLAAYLHRTRMPFNLTVLAQAAGLAALEDTEHVRRTREVNRAGLDYFAAELPMLGGTLTHSHANFVFVDFGRPAVALYEQLLRKGIIVRPFAGQGFPNHVRISVGTPAENARCVQVLKEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5B3</accession>
    <name>Q1D5B3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553990.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3980"/>
    <dbReference type="EnsemblBacteria" id="ABF89561">
        <property type="protein sequence ID" value="ABF89561"/>
        <property type="gene ID" value="MXAN_3980"/>
    </dbReference>
    <dbReference type="GeneID" id="41361312"/>
    <dbReference type="KEGG" id="mxa:MXAN_3980"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794164_0_0_7"/>
    <dbReference type="OMA" id="VAMQDMV"/>
    <dbReference type="OrthoDB" id="540798at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="39455" checksum="4B0DF327DF554D99" modified="2006-07-11" version="1">MVEVRAFEGGAKEASQFINSVWQRTYGAKMGLTIWDERFFDWLLFSNPLADRDYLLGAYSKGKLVGAFLAEPAKIQLGQRQVDGTYGSWVSVAPESRGQGIGIKLSDTMQARHRERGAALTLSCVADGTLGQGFWSRRSHTRYLNNLGMWLHIFNTEKAVRWSLSAAERAFLTFTRPLHRRDFLAARTDNIRAYQPRDLPQCMALVQKMMRPVNLGYAYTSERLAHQLQFRDIPHTFVLERDGVIQGMVNYYTLQMTARGLLTTGLVDLLAFQDGLPFSEQRRLLWVAMQDMVAQGADCAAMLRSPCTPTHLMLRSGWLPFPGGSRVTCLLTTPDVELPASPRVFMHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5M2</accession>
    <name>Q1D5M2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553881.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3871"/>
    <dbReference type="EnsemblBacteria" id="ABF91533">
        <property type="protein sequence ID" value="ABF91533"/>
        <property type="gene ID" value="MXAN_3871"/>
    </dbReference>
    <dbReference type="GeneID" id="41361204"/>
    <dbReference type="KEGG" id="mxa:MXAN_3871"/>
    <dbReference type="eggNOG" id="COG4531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042661_0_0_7"/>
    <dbReference type="OMA" id="ASLDWLM"/>
    <dbReference type="OrthoDB" id="1778971at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="43919" checksum="90C417BF5EA15CA6" modified="2006-07-11" version="1">MTATVLTRLNLGRRVVWGAVAVGGLGLLATLLGGVAAPREAAYGYLFAFAFWLTLSLGALIILASFHASRARWPTVLRRPLEVMAASSPVFVLLFVPVVLTMPHLFPWVAIPADLSAHDVHLLAHKKPYLNVPFFLGRAVFYFAVWSVVGLLLYRWSVRQDAEPAITERAVRFTLYQRKLGAGSLPLMVLCLSFASLDWLMSLEPLWESTVYALTLGCGAVVGALALVAVVAATARGAGQFGALMGPAHFLRLGTLLLAFVCLWAYGAFSQLLLIWIASLPEEVTWYRARLDGGWLAVAVVLAVGHFVVPFFLLLLRRLKQDPRALAVVGAWLLLMRALDVYWLVFPALHPGTASFHWTSVTAWAGVGGWTVAAWWLLSRGGYTVPVRDPFLPHSLRVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5W5</accession>
    <name>Q1D5W5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553789.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91011">
        <property type="protein sequence ID" value="ABF91011"/>
        <property type="gene ID" value="MXAN_3776"/>
    </dbReference>
    <dbReference type="GeneID" id="41361108"/>
    <dbReference type="KEGG" id="mxa:MXAN_3776"/>
    <dbReference type="HOGENOM" id="CLU_1336845_0_0_7"/>
    <dbReference type="OMA" id="VEFETYM"/>
    <dbReference type="OrthoDB" id="1284523at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="23832" checksum="E3A353314BE46A2E" modified="2006-07-11" version="1">MFEAWMLRRLSAPTAAATLLLLSASGCVKEISSDERLDRETQNLSAKEMPGAAELEKLTCEDSTEALIKARNVNRPETDRLVDYIELYSSLRKRTATFEDAMNRNPDLSYREGTQHLVNAKDNCIQQTADVRVEFETYMRELVGVPTVQEIKGGNTVTIARLDFNTLRQAIETLEPDDKDTLLNQVNAAEKRVAPSTPAGDESAPASGGGRKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D677</accession>
    <name>Q1D677_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3659"/>
    <dbReference type="EnsemblBacteria" id="ABF88437">
        <property type="protein sequence ID" value="ABF88437"/>
        <property type="gene ID" value="MXAN_3659"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3659"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141550_0_0_7"/>
    <dbReference type="OMA" id="SMGAKEY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17236" checksum="5C9856E0E5A63366" modified="2006-07-11" version="1">MVMGSRTGAARTRESPMNTLRGLCTFNLWADDLRAATRWYAEQLGVEPYFSSEAAGRGLGYVEFRIGDYQHELGIIDRRFAPPGLATARGGTVAYWHVDDIAATLDQLLSLGAQLLEGVTERGPGFVTASVIDPFGNVLGVMFNRHYLDVLGGARGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6A8</accession>
    <name>Q1D6A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-ribosomal peptide biosynthesis thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553646.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3628"/>
    <dbReference type="EnsemblBacteria" id="ABF90669">
        <property type="protein sequence ID" value="ABF90669"/>
        <property type="gene ID" value="MXAN_3628"/>
    </dbReference>
    <dbReference type="GeneID" id="41360966"/>
    <dbReference type="KEGG" id="mxa:MXAN_3628"/>
    <dbReference type="eggNOG" id="COG3208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070456_1_1_7"/>
    <dbReference type="OMA" id="GQHFFIR"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="27701" checksum="7355E8984469A11B" modified="2006-07-11" version="1">MTDWLAFHVPAPASWVRLFCLPHAGGSASLFRTWQAELGQDIEVCPVQLPGRENRLREPPLRALPDVIAPLVDVLAKHTDKPYALFGHSMGALLAYELTRALRERGLPAPLHLFVASYRAPHTLQAHTPATATHDIDASEARRLGESRAVSGEMAEELLTLMRATMLADTAVCEGYAWKPGPILACPLSAFRGFDDYVPDDATEAWRQLTSGPFATQTFLGDHFFLRQTPRGLLQNIRRSLTRLRPASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6F6</accession>
    <name>Q1D6F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553603.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3577"/>
    <dbReference type="EnsemblBacteria" id="ABF87012">
        <property type="protein sequence ID" value="ABF87012"/>
        <property type="gene ID" value="MXAN_3577"/>
    </dbReference>
    <dbReference type="GeneID" id="41360923"/>
    <dbReference type="KEGG" id="mxa:MXAN_3577"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562383_0_0_7"/>
    <dbReference type="OMA" id="YANVRFV"/>
    <dbReference type="OrthoDB" id="250960at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="221"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="53158" checksum="DA2494F9EA73288E" modified="2006-07-11" version="1">MRHLRTSVPVALLGLLAACGGPVESQPEVEIATTESALNCDSMSRAVHHRIKPANEDSLYTLNANEAANAATTWGYTEDRGVAFLAAASTGTGLSPVYRIYSPSRQEHFWTIDEAERNDLMQNGGYTTDENVGFYASKTAASCLVPVYRFSNTTLRKHRFAITEAQRDALASTGWVNQGIKFYAAPESAPPVDTKFTFAVIPDTQNEVLTTPPTRLTHRLQWLVDNRSSLDLRFVLHTGDVVNWDTPDHIQYVRASEATEILDAAGLPYVYAIGNHDTAAVCPGGSACPGNVNANLRDTTTFNAHFPLTRFTALGGVYEPGKIDNSYHTFSAGDLDWLVLNLELWARTGAVDWAKTVLAQHPRHNVIINTHSHLNGSGAIEQSNGGYGNNSPQYVFDQLIKQYANVRFVFSGHTGNAAYRTSTGVHGNTIHQILTSYHENTSNLTRLVEVDTAANTFSTRVYSPMTNAEKQDGSKFAISNVSWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6W1</accession>
    <name>Q1D6W1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553448.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3415"/>
    <dbReference type="EnsemblBacteria" id="ABF88611">
        <property type="protein sequence ID" value="ABF88611"/>
        <property type="gene ID" value="MXAN_3415"/>
    </dbReference>
    <dbReference type="GeneID" id="41360762"/>
    <dbReference type="KEGG" id="mxa:MXAN_3415"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_7"/>
    <dbReference type="OMA" id="ACGMNMV"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="767"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="YHS" evidence="8">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="9">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HMBD" evidence="9">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="821" mass="87362" checksum="2B50702CE4403254" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A3</accession>
    <name>Q1D7A3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553316.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3271"/>
    <dbReference type="EnsemblBacteria" id="ABF91169">
        <property type="protein sequence ID" value="ABF91169"/>
        <property type="gene ID" value="MXAN_3271"/>
    </dbReference>
    <dbReference type="GeneID" id="41360623"/>
    <dbReference type="KEGG" id="mxa:MXAN_3271"/>
    <dbReference type="HOGENOM" id="CLU_1359192_0_0_7"/>
    <dbReference type="OMA" id="GCSKRDN"/>
    <dbReference type="OrthoDB" id="1701963at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="21753" checksum="03B478BCA8CE31F9" modified="2006-07-11" version="1">MRKLMMAVTAVAGMSLVVTGCSKRDNVESQRQDVAEAQVEAQQKTAEVRQDAREDIARTQIEAQEDIAGTQREAAEEVASAQQDVQDERQDLAEAEADRRTDLNGDMALGGSGAAGATAAASSVSGRVLSTGNDELTVVDTSNNKQLELKTNDQTRILHNNQPLKLDDIEEGAQVRASYVRDGEDMVVRELTVTQPVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W3</accession>
    <name>Q1D7W3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553107.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3052"/>
    <dbReference type="EnsemblBacteria" id="ABF89737">
        <property type="protein sequence ID" value="ABF89737"/>
        <property type="gene ID" value="MXAN_3052"/>
    </dbReference>
    <dbReference type="GeneID" id="41360414"/>
    <dbReference type="KEGG" id="mxa:MXAN_3052"/>
    <dbReference type="HOGENOM" id="CLU_1061013_0_0_7"/>
    <dbReference type="OMA" id="EVFVKSQ"/>
    <dbReference type="OrthoDB" id="1668122at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="28037" checksum="EEE0747B7DD88090" modified="2006-07-11" version="1">MKVDSREPTSGSGQTKSSADGERFKKALDEADARSSPPRPQRLGLNPRSAARTGPTPTLLARASGPVLTAQRGAVSSPESLGLKRQAMNVEVQRLGTVRSESQALGQERTEHRLHDLIARELSKDLRPALPVQPEARPAPGPPPPDEKRPLQEPMGSENATAVTASAGGAHAPAEEVTPAARAEAAMALIERIEVFVKSQRPALSMSLRGHLDATVEVERTGPREVSLRIQGRHRPVAAEDLSRLRDALESLGLKLSSLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D812</accession>
    <name>Q1D812_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA topoisomerase 1</fullName>
            <ecNumber evidence="11">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">topA</name>
        <name evidence="14" type="ORF">MXAN_3002</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3002"/>
    <dbReference type="EnsemblBacteria" id="ABF88835">
        <property type="protein sequence ID" value="ABF88835"/>
        <property type="gene ID" value="MXAN_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3002"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
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        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="464"/>
            <end position="572"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
            <end position="461"/>
        </location>
    </feature>
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        <location>
            <begin position="622"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="614"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1242" mass="136417" checksum="CC44B08F8921B677" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D843</accession>
    <name>Q1D843_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2971"/>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2971"/>
    <dbReference type="eggNOG" id="ENOG5033AW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138568_1_0_7"/>
    <dbReference type="OMA" id="SCRNCRH"/>
    <dbReference type="OrthoDB" id="2043883at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="95" mass="10626" checksum="269CFADB8910AD4D" modified="2006-07-11" version="1">MPGCAHCGHRLDIIANQVGRRDECPHCGEDIRSCRNCRHFDLGVAKECKEPFAEVPKDKDGANFCELFQIGEGGIHEKESRDALLNAAESLFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D859</accession>
    <name>Q1D859_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2954"/>
    <dbReference type="EnsemblBacteria" id="ABF86516">
        <property type="protein sequence ID" value="ABF86516"/>
        <property type="gene ID" value="MXAN_2954"/>
    </dbReference>
    <dbReference type="GeneID" id="41360317"/>
    <dbReference type="KEGG" id="mxa:MXAN_2954"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_7"/>
    <dbReference type="OMA" id="KCPHKGG"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="12056" checksum="1FC1727A98C7E662" modified="2006-07-11" version="1">MNGHLDGGFIPVATLDVLDARGRAVVQVDGVAVALFRVNGELHAVADACPHRAGPLSEGDLVGYVVHCPLHTWPFDIRTGQCPRHPGVQVRTYVVRVQGQHILVSASGRVHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8D7</accession>
    <name>Q1D8D7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552936.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2875"/>
    <dbReference type="EnsemblBacteria" id="ABF90901">
        <property type="protein sequence ID" value="ABF90901"/>
        <property type="gene ID" value="MXAN_2875"/>
    </dbReference>
    <dbReference type="GeneID" id="41360244"/>
    <dbReference type="KEGG" id="mxa:MXAN_2875"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_6_0_7"/>
    <dbReference type="OMA" id="LSFQNFF"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
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    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="42654" checksum="484952E4B78CA48E" modified="2006-07-11" version="1">MKASRRQLPVYVPPRTVWIVGTQVLLLILCWAALRAVYPVLTLLAVVLLLSIALSPLVRRLTQWGLPRGAGVAIVALALLGMMGVLVGSLVPMLIHQLQGLVQSMPAMLERLAQSRWVEELSTRYGVEVQAEDLIRFEPTDVAGRLINVLSSTLGLVAGGITVVVLTVFSLLFGEDLYESTIQWVSPRRRPRVRLLMSRMRKAVANYLAGTLLVMTIGGTVAATIALIQGVPYFLPLGLMVMMMGVIPYLGSIISAVLVGVITLAAVGLKDALIAVVVFIVYQQIESNVLGPMIQRRAIKMNPLLISIVVLCGGALAGLPGVVLAVPLAAAAQVLVQEVLGLRQEAWQRSHRMEDSKREPGRGAVEEGLLFAGPMAGPRPSAPPSREPPPPDTPSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8J9</accession>
    <name>Q1D8J9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GSPII_E domain/HD domain/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552874.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2807"/>
    <dbReference type="EnsemblBacteria" id="ABF87190">
        <property type="protein sequence ID" value="ABF87190"/>
        <property type="gene ID" value="MXAN_2807"/>
    </dbReference>
    <dbReference type="GeneID" id="41360183"/>
    <dbReference type="KEGG" id="mxa:MXAN_2807"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415508_0_0_7"/>
    <dbReference type="OMA" id="EFQTRFV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
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            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="660" mass="70621" checksum="0D91D3F561037CC0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8N6</accession>
    <name>Q1D8N6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">gvpA</name>
        <name evidence="5" type="ORF">MXAN_2770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552837.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2770"/>
    <dbReference type="EnsemblBacteria" id="ABF89003">
        <property type="protein sequence ID" value="ABF89003"/>
        <property type="gene ID" value="MXAN_2770"/>
    </dbReference>
    <dbReference type="GeneID" id="41360147"/>
    <dbReference type="KEGG" id="mxa:MXAN_2770"/>
    <dbReference type="eggNOG" id="ENOG5032YMQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169045_1_0_7"/>
    <dbReference type="OMA" id="IDVWARV"/>
    <dbReference type="OrthoDB" id="1823180at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="74" mass="7576" checksum="02D22FBAD5495E00" modified="2006-07-11" version="1">MANVSTSTGTTSTADVIDRILDKGIVVDAWVKVSLVGIEVLSIEARVVIASIETYLKYADAIGLTAAAAAPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8U5</accession>
    <name>Q1D8U5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552778.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2711"/>
    <dbReference type="EnsemblBacteria" id="ABF90134">
        <property type="protein sequence ID" value="ABF90134"/>
        <property type="gene ID" value="MXAN_2711"/>
    </dbReference>
    <dbReference type="GeneID" id="41360089"/>
    <dbReference type="KEGG" id="mxa:MXAN_2711"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_2_7"/>
    <dbReference type="OMA" id="CRIADVA"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013570">
        <property type="entry name" value="Tscrpt_reg_YsiA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08359">
        <property type="entry name" value="TetR_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="25378" checksum="8470F540B8F115B7" modified="2006-07-11" version="1">MGQQSKPAAESGTRESERRRTILRAAIDVFARKGYHGCRIADVAKEAGVAYGLVYHYFKNKDELLETVFDTGWSGFVTRVRAVVEGEGPLAEKVRGIVEVAFEAYRVDPRAVKVLILEIARSPAGSRINRQTAFVDAIRLSSALFNAAQERGELRPGLDPHLASALLFGNIEMALTAFVVGLADARDPDALERAKSQIADSFLYGVLTGAQAAEVSEWKPEKSATKSKAPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8V0</accession>
    <name>Q1D8V0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552774.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2706"/>
    <dbReference type="ESTHER" id="myxxd-q1d8v0">
        <property type="family name" value="Abhydr_predicted"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.020"/>
    <dbReference type="EnsemblBacteria" id="ABF92631">
        <property type="protein sequence ID" value="ABF92631"/>
        <property type="gene ID" value="MXAN_2706"/>
    </dbReference>
    <dbReference type="GeneID" id="41360084"/>
    <dbReference type="KEGG" id="mxa:MXAN_2706"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646937_0_0_7"/>
    <dbReference type="OMA" id="QFARWIR"/>
    <dbReference type="OrthoDB" id="891360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="64"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="48280" checksum="1D29CA0994BEAE5A" modified="2006-07-11" version="1">MRLPDWRAAATSGPPIPSIDEVDFRALYSKTKYVVETADGWSLVITRYRPVKQPFPQPLFGEPLLLVHGFSQNRHTWTSGQFVKNLLFFGVDIHILELRGHGKSSIAFQKERAERFKRPLPPDLDYGWDIDSYFLYDLPAAVSGVKRITRRERIFYCGHSMGGMLGYGYAGIHNDFEGLITIGSPADLGRGFMLLRLLAHGAPMLAGMIDLTLASLNVGGKVEGAGRSLLARGVGVLNKGLGRRLSPRARRTLRFDAVPVDIILKTLERQLAKAEDSPLYQQLTTRLNRLINPERVSADDIRWLLREGGEREPRRVLEQFARWIRRGEMVCYRTGFDFKRGFGRIEVPMAIIFGDLDPLASLESTRSVYRAAKSEYLLWRPVKGNSHIELTMGHDIRQICYDIKNLIEYARTHRYRSPSLPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8X2</accession>
    <name>Q1D8X2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator CheY4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY4</name>
        <name evidence="3" type="ORF">MXAN_2684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552752.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2684"/>
    <dbReference type="EnsemblBacteria" id="ABF88007">
        <property type="protein sequence ID" value="ABF88007"/>
        <property type="gene ID" value="MXAN_2684"/>
    </dbReference>
    <dbReference type="GeneID" id="41360062"/>
    <dbReference type="KEGG" id="mxa:MXAN_2684"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="MHFTKPF"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="14110" checksum="8A03ADD1D78D8991" modified="2006-07-11" version="1">MNAKVLIVEDTKTITNLLQVYLMGWGLEFFDAPNGAIGLTKARELKPDLIISDVQMPEMDGFALCAAIRADRQLHDTPFMMLTSLKDDASRQKGKLVGASAFLNKPVSVDDLRSKVRDILKLPATRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D964</accession>
    <name>Q1D964_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552660.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2590"/>
    <dbReference type="EnsemblBacteria" id="ABF91780">
        <property type="protein sequence ID" value="ABF91780"/>
        <property type="gene ID" value="MXAN_2590"/>
    </dbReference>
    <dbReference type="GeneID" id="41359968"/>
    <dbReference type="KEGG" id="mxa:MXAN_2590"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_7"/>
    <dbReference type="OMA" id="WIDICGA"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="18919" checksum="6358E885F2998F00" modified="2006-07-11" version="1">MTDLSAKNPKDTEVVMTQLILPPDANNLDAAFGGKVMQWIDICGAVAAQRHCRQVVVTASMDDLHFHAPIKVGWVALLHGRVLAAFRTSMEVGVTVHAENPLTGERHLTTSALLTFVAIDKDGQRVPVPPLLMETDADRMAFQEAQTRRTLRLARQKENQSWLKVMTPIAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9C0</accession>
    <name>Q1D9C0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5 7" type="primary">purK</name>
        <name evidence="7" type="ORF">MXAN_2534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552604.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2534"/>
    <dbReference type="EnsemblBacteria" id="ABF86046">
        <property type="protein sequence ID" value="ABF86046"/>
        <property type="gene ID" value="MXAN_2534"/>
    </dbReference>
    <dbReference type="GeneID" id="41359912"/>
    <dbReference type="KEGG" id="mxa:MXAN_2534"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_1_7"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="OrthoDB" id="1165275at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="112"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="153"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="380" mass="40254" checksum="3FC4A21B48A44BA5" modified="2006-07-11" version="1">MSPRVVLPGGTIGMLGGGQLGRMMALAARTLGFQVQALDPDADCPAHSVVDLCVTASFGDTAAAETLARACDTVTLEIEKIPLPTLEAVARHTPMRPGADVLRVIQHRGRQKGWLAKGGFPLGPWREAHSAAELAEAIQALGGRCFVKSSEGGYDGRGQVEVTSADEAAQAWRELGERSVVVEAALALQSELSVLVARSPNGEVAVYPPAFNHHEERILAWSLLPGPLPPAVLDTATELARGITESLQVEGLLVIELFLLKDGSVLVNELAPRPHNSFHSTEVACLTSQFEQAVRAVCNLPLGSVEVVRPAAIVNLLGDLWLKDGGPRFQEVLAMPGVRLHLYGKREARKGRKMGHLSAVGSSPEDALARVQAAATALGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9F2</accession>
    <name>Q1D9F2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AsmA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552573.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2502"/>
    <dbReference type="EnsemblBacteria" id="ABF87979">
        <property type="protein sequence ID" value="ABF87979"/>
        <property type="gene ID" value="MXAN_2502"/>
    </dbReference>
    <dbReference type="GeneID" id="41359880"/>
    <dbReference type="KEGG" id="mxa:MXAN_2502"/>
    <dbReference type="HOGENOM" id="CLU_860041_0_0_7"/>
    <dbReference type="OMA" id="EDHASHQ"/>
    <dbReference type="OrthoDB" id="821742at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030925">
        <property type="entry name" value="T2SS_GspN_Lepto"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04411">
        <property type="entry name" value="T2SS_GspN_Lepto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="2">
        <location>
            <begin position="120"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="33417" checksum="2CCB1AEB93B36134" modified="2006-07-11" version="1">MSTDSKAARWKILLGYAAFAVVAFVVGLLVTFPYDAIRKRLVSEAAQAGLAVRIGSLRPGLAGITATNVRVSKPPQPLSADTVAALARGEGMLGAAELGEPLVLDSVALRPALFPPGIALRASVMGGTLSASVGLLGDTRVKVTADGLQASGGNLPAFTGMDLDGELNAALSLTMPKSGAQPDLSQANGELTLDTRNMVIKSGKVAIPMGGGTAVPMDLPQIDLGALTGRIQFVKGLGTVESLRLKSNELEAVATGTLKLGKRLEYSEPGMDVNIKLDPEFQKRLGLVGAGVTILPPDKTDPSFRAARLAGFLNRPTFLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA09</accession>
    <name>Q1DA09_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552369.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2293"/>
    <dbReference type="EnsemblBacteria" id="ABF86586">
        <property type="protein sequence ID" value="ABF86586"/>
        <property type="gene ID" value="MXAN_2293"/>
    </dbReference>
    <dbReference type="GeneID" id="41359680"/>
    <dbReference type="KEGG" id="mxa:MXAN_2293"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_7"/>
    <dbReference type="OMA" id="RAMEFMP"/>
    <dbReference type="OrthoDB" id="1337662at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="30287" checksum="E67CB52AD0D57650" modified="2006-07-11" version="1">MDTEALARIPGVNPNVPNAARIYDYTLGGTHHFEADRQAAEYLFSLVPSTRKWVPMLRACLRTAAQRLAADGFHHWVDFASGLPTGDHVHAVLPDARVLYSDVNPLTITTAHHLLGDTPRVRYMECDIRQAGAFLRRPDVNAFLGGERRVAFGANGITVFLSAEENRQFFRDLYDWAAPGSKLFTTFETKSPDLSTPKWEQFVGMFRQMGESFQLYSLPEYLDLCGPWARDATGVLPVREFLGLPPEHITDEDREGVGIEFYAVVLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI2</accession>
    <name>Q1DAI2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposition helper protein, IS21 family, truncated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2115"/>
    <dbReference type="EnsemblBacteria" id="ABF86690">
        <property type="protein sequence ID" value="ABF86690"/>
        <property type="gene ID" value="MXAN_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2115"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_1_2_7"/>
    <dbReference type="OMA" id="NGNSYRM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="93"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="25034" checksum="E789C0C067BE525F" modified="2006-07-11" version="1">MVRYTQKLRLSGLLQSLELRCREAADANLPLTEFLYRLLADEVERRDGKQLDVRLRRAAFERPSTLEDFDFSFNVSVPRTQVLELGTCTFVERHENVLVVGPAGVGKSHLAQALGQRACRAGHAVLYVSAHDMLTQLRASRADNSYERRLLRFTTPALLIIDDLGLRPLTGEEGIDMYEIVRRRYERVADFNADGRLDVAATIAAANTVSLFPGLGDGSLSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK7</accession>
    <name>Q1DAK7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552171.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2087"/>
    <dbReference type="EnsemblBacteria" id="ABF91449">
        <property type="protein sequence ID" value="ABF91449"/>
        <property type="gene ID" value="MXAN_2087"/>
    </dbReference>
    <dbReference type="GeneID" id="41359494"/>
    <dbReference type="KEGG" id="mxa:MXAN_2087"/>
    <dbReference type="eggNOG" id="ENOG50339XT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773450_0_0_7"/>
    <dbReference type="OMA" id="AYFGELR"/>
    <dbReference type="OrthoDB" id="613606at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="358" mass="39672" checksum="C9557D4A08AFC428" modified="2006-07-11" version="1">MSARLQPEELFQAARERAAQLDVGRGDAAVERVRAAASALFVRIPEPPVYRRAEDPSRKAAQALLPEVERVLAEALAAGRDVSAVAPLEKLVAALLAHGEALCHTAAGRLEAAETAWRRAQELERAAHPTRHLVTSPPRPPPVFDKGSRVSRYDPRPAPQASVKLVCPNMGCKRVGDYAFLTSHAYNRFICPVCRTPFLAYFGELRGLEVEVGRSSKRYFFTVDEVGTTGSTRIEFEEASGQEFPSARRDLLAFVYTEARELKAVVNLTNQRLMWVSPASSCFVATVAFGAGAPELVAFRAYRDDVLRKSAPGRVFIRGYYRWGPDVAAWVSRRPAAREGVRWVLRRVHGRLTRSGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAS5</accession>
    <name>Q1DAS5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oligopeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552103.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2019"/>
    <dbReference type="EnsemblBacteria" id="ABF87270">
        <property type="protein sequence ID" value="ABF87270"/>
        <property type="gene ID" value="MXAN_2019"/>
    </dbReference>
    <dbReference type="GeneID" id="41359429"/>
    <dbReference type="KEGG" id="mxa:MXAN_2019"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946317_0_0_7"/>
    <dbReference type="OMA" id="RPWEKLF"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="31412" checksum="24EE0C3F36696054" modified="2006-07-11" version="1">MRAIAQRLLRQVVLVPVVAVASYFLMASLPLTTETDAKRQVSRELAASYRRDLGIGEPLGFLRPWEKLFRGERLGTSAQGITGDELLTKLSGSVGVGLMALPLSLTWALGFALLRTRWRKGPWAALGDVVPAVAFGTPVFIPALLLAPGVVERGHLLPELCAALVTSIWPGIFLGTLVGDSLEAELSRDYVRTALGKGLSRAAVLRRHVLPNVWPAMLDAVGPVATSLLAGSFAAERVLGLPYFGQLYVLAVLNKQVAVVVVATTTFAALLVIVSLAVEVLRYAVDPRSREASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB93</accession>
    <name>Q1DB93_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551936.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1834"/>
    <dbReference type="EnsemblBacteria" id="ABF89002">
        <property type="protein sequence ID" value="ABF89002"/>
        <property type="gene ID" value="MXAN_1834"/>
    </dbReference>
    <dbReference type="GeneID" id="41359251"/>
    <dbReference type="KEGG" id="mxa:MXAN_1834"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1914135_0_0_7"/>
    <dbReference type="OMA" id="HVHAELV"/>
    <dbReference type="OrthoDB" id="2096798at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16449" checksum="D1BD45398B008E51" modified="2006-07-11" version="1">MAIHEITAEDVLQRCARCGSGNRLSLDTLEVGVARREDVDDGLVQLPPCPACRSTEFLIRAPEGEPEHPAPGSFGHLHRLLVGHVHAELVKRGRLHTVLKPKGGGAGKVVVRPLSQEARERWFPQGLRIEVPPGERRAHPEASSQDTPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI8</accession>
    <name>Q1DBI8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551844.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1735"/>
    <dbReference type="EnsemblBacteria" id="ABF92416">
        <property type="protein sequence ID" value="ABF92416"/>
        <property type="gene ID" value="MXAN_1735"/>
    </dbReference>
    <dbReference type="GeneID" id="41359168"/>
    <dbReference type="KEGG" id="mxa:MXAN_1735"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567211_0_0_7"/>
    <dbReference type="OMA" id="LYWSDFN"/>
    <dbReference type="OrthoDB" id="387178at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="DUF5050"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188453" evidence="1">
        <location>
            <begin position="32"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5050" evidence="2">
        <location>
            <begin position="241"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="482" mass="49169" checksum="5E052C0F23285B1D" modified="2006-07-11" version="1">MSYLLSRWLTAPAAALRAGLVIGLAASTLGACRDNDPPPNAPPVASDITLETVEDTPLEVRLPASGNGALAFTIVDTPDHGTLSEISANGSVTYTPGADYNGVDALIFRATNREGQSAQATVSITITPVNDTPTLSSVADQSIPAGSSTGDLAFTVGDVETAADSLTVIATSSNTDLVPNDPSNLALGGSGSSRTLSVVPVASASGSTTITLSVSDGSDTTSTTFTVDVTGLASLYWMTAAGSLWRVDVNGTNAIELETGISGASSVAADPVTRTLFYTRDSAIVRADSDGANPVDIVANGGYPSGLAVDSTNRKLYWSDFNGSRVMCAELDGSNPTQVVGGIGSPSAIAVDVPNGSVYVIAYNNTRLVRFNLDGTNLETLASNLGGLGVGLAVDSSGGKVYYSTRGNSIYVANLDGSDVTTLVTNQTTVHGIAIDVTAGRLYWADWLGTVLRSANLADGSDIQDVNSGSARNLGLAWMPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC66</accession>
    <name>Q1DC66_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551616.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1505"/>
    <dbReference type="EnsemblBacteria" id="ABF89582">
        <property type="protein sequence ID" value="ABF89582"/>
        <property type="gene ID" value="MXAN_1505"/>
    </dbReference>
    <dbReference type="GeneID" id="41358951"/>
    <dbReference type="KEGG" id="mxa:MXAN_1505"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116683_0_0_7"/>
    <dbReference type="OMA" id="HRCEKHE"/>
    <dbReference type="OrthoDB" id="1639031at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="21702" checksum="9671465F7443C4C7" modified="2006-07-11" version="1">MLLLDGVGTVRRTRHFMKEGQPMPNDREQGKGAPQGSERQASRRDTPIEVRRRLRHESRTSQTYAAFIKHLCERGGMSPAVAEKAAVSVLCALEQRILSEEASDLEDQLPRKLTLLLHRCEKHEEELPPKFHREHLLRRVGEDLSLHPDAVEPVVRAVMDAVRHQITEGESEDVMGQLPPDIRDLWTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM8</accession>
    <name>Q1DCM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551455.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92147">
        <property type="protein sequence ID" value="ABF92147"/>
        <property type="gene ID" value="MXAN_1338"/>
    </dbReference>
    <dbReference type="GeneID" id="41358784"/>
    <dbReference type="KEGG" id="mxa:MXAN_1338"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793223_0_0_7"/>
    <dbReference type="OMA" id="MSMRLRT"/>
    <dbReference type="OrthoDB" id="1540229at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15856" checksum="2DF518BFAC5DB7D3" modified="2006-07-11" version="1">MSMRLRTRWLPIIFFALAGCGEETELPQAPTLFIDRAALTFNREFNHGTYVGQTAYNSLAIQNRGLDPLDITAITLSAPSVFTLQLPEGFTPGTPLRLETYDRAYLTVAFMPTDDVEYNGTITIESNAANAAQQVITLNGLGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDG2</accession>
    <name>Q1DDG2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551171.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1050"/>
    <dbReference type="EnsemblBacteria" id="ABF90995">
        <property type="protein sequence ID" value="ABF90995"/>
        <property type="gene ID" value="MXAN_1050"/>
    </dbReference>
    <dbReference type="GeneID" id="41358503"/>
    <dbReference type="KEGG" id="mxa:MXAN_1050"/>
    <dbReference type="eggNOG" id="ENOG5031H2C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182005_0_0_7"/>
    <dbReference type="OMA" id="SEKLCDC"/>
    <dbReference type="OrthoDB" id="1812972at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10421" checksum="AB6CB21E6F7A4EC5" modified="2006-07-11" version="1">MFAAAMRRFIVTAALLCSALSGLTGCKGACRELSEKLCDCSINSVEKELCLRRASQEENRVEPTAEDEAVCEERLAGCDCRAIETDEGKRACGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDJ5</accession>
    <name>Q1DDJ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551138.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1017"/>
    <dbReference type="EnsemblBacteria" id="ABF89211">
        <property type="protein sequence ID" value="ABF89211"/>
        <property type="gene ID" value="MXAN_1017"/>
    </dbReference>
    <dbReference type="GeneID" id="41358472"/>
    <dbReference type="KEGG" id="mxa:MXAN_1017"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260320_0_0_7"/>
    <dbReference type="OMA" id="RWEALAC"/>
    <dbReference type="OrthoDB" id="1529619at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23089" checksum="BF45E326B2FAAC03" modified="2006-07-11" version="1">MRPRNRGMTLLEVMVVVALVGLFATLSVSSFQGMTERQRLSAAQRELVLMMQEARQKARATHQPVRLGTRVMDEQGVQVTRMRWEALACSDAWGTVCPMPACQENACGVGGCECAELGPELVIPPKLDVELLVGLCWLGNPSAGAPVVAPPAPGGRVCEQNAPLPPTERLILLRNRGTLEAPDWKPELVFQADGLTAAIRPLDCDKHASTPGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDN8</accession>
    <name>Q1DDN8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0974"/>
    <dbReference type="EnsemblBacteria" id="ABF91310">
        <property type="protein sequence ID" value="ABF91310"/>
        <property type="gene ID" value="MXAN_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0974"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2207187_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="11244" checksum="F331621FE3045882" modified="2006-07-11" version="1">MSVNASCGFHFRHGIFHSRQGLAGMPGARGGCRRCVGVLVPTLKPEYADILRKVDLVERGVPGVAREALKKQLERSCGSCAAHGCLDCSCKPSHRAGEALAPGSADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDQ8</accession>
    <name>Q1DDQ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551075.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0954"/>
    <dbReference type="EnsemblBacteria" id="ABF88503">
        <property type="protein sequence ID" value="ABF88503"/>
        <property type="gene ID" value="MXAN_0954"/>
    </dbReference>
    <dbReference type="GeneID" id="41358413"/>
    <dbReference type="KEGG" id="mxa:MXAN_0954"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930088_0_0_7"/>
    <dbReference type="OMA" id="VIFEMNC"/>
    <dbReference type="OrthoDB" id="1340956at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="88"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="33849" checksum="5C1775A39E135817" modified="2006-07-11" version="1">MRPITPALRAARLAHTFLLFSQLRTARLLLELNGQQPLEVQRRLFGYDLTLKAHRSTTHMLLYLQGDDFLSDLPLIAPHLRPGMVAFDVGANIGYLSMYLRSRIGPLGQLFSFEPEPENYAELDANFRNNHLRNCQAIQTAVGSQEGVITFATGLNGHVPVEGAEGISVPVVTVDGFVQKQGLSHVDFVKVDVEGFELDVLAGMRATLERPDKPILYIKVHGRGEYARADPRRVCEVLEGHYKNIRAYLPPDDFKAKRSHLRRLWGRVSPFDDIEQACRVDLREVKQHDTQRYQLLCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDR6</accession>
    <name>Q1DDR6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551067.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0946"/>
    <dbReference type="EnsemblBacteria" id="ABF90282">
        <property type="protein sequence ID" value="ABF90282"/>
        <property type="gene ID" value="MXAN_0946"/>
    </dbReference>
    <dbReference type="GeneID" id="41358405"/>
    <dbReference type="KEGG" id="mxa:MXAN_0946"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_3_4_7"/>
    <dbReference type="OMA" id="PLYDDRP"/>
    <dbReference type="OrthoDB" id="1885303at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="192"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="38148" checksum="A155F4703E2C59C3" modified="2006-07-11" version="1">MSREDSRLALEWHTWLAENLALGVSAEDAQRVLVDAGVEASLAQREIATAQAHPYVVAARRIGRRYEWLEALADLYAELHRQSGAVTLEKRRGVSPEEFFTRYYFGHRPVVLQGFMEDWPAMRRWSLADFRERFGDVEVEIMSGRDANPDHASQPDKHRQVVKLRDYVQRVETGGESNDFYMVPRNENWKRDGLARLREDIRAPAGIIDPELRPDMTTLLLGPPGTVTPLHHDNMNVLLGQVMGRKHVRLVPSFQRHLVYPRHGTFSSVDAASPDAARFPLYGEATVLEGVVEPGELLFLPVGWWHWVRALDVSATVTFHHFQLPGGNTHLRTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE30</accession>
    <name>Q1DE30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
            <ecNumber evidence="2">1.5.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lys1</name>
        <name evidence="2" type="ORF">MXAN_0831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.7" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550953.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0831"/>
    <dbReference type="EnsemblBacteria" id="ABF89202">
        <property type="protein sequence ID" value="ABF89202"/>
        <property type="gene ID" value="MXAN_0831"/>
    </dbReference>
    <dbReference type="GeneID" id="41358294"/>
    <dbReference type="KEGG" id="mxa:MXAN_0831"/>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065104_1_0_7"/>
    <dbReference type="OMA" id="GVWFPEH"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="40089" checksum="760F54FA56CA1DBE" modified="2006-07-11" version="1">MDGPRRRVERAMVAEDSVVLVGGYGVVGTWLAQLLRERHPDLPLVIAGRRREPAEALARRLGNAEAVVLDVTAPDPLACLSGRPRAVVSLVNDPDDAVLRSAVREGVAVLDITRWTSRVKSAVLRLSGTPPRAPVLLSSAWMAGLVPRLVAGASERVGGVERVDVGIRFALADQAGPDSVEYMDRLGMAFDITEGGKERQVLPLTDGRRVMFPDGRPTRVFRLDTPEQATLPLVLGARTVSTRLGFDSGTVTWMLAALQQVGLLRLLQHPRLTSVRRALMASSGTGGEAAWVADVEGPRGALRIEVVDPKGQAHLTAVGAVLGTERLLGWDGAPPPAAGVWFPEHDARPEQALAALRGCGVQVRFEEQSRREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE46</accession>
    <name>Q1DE46_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550937.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0814"/>
    <dbReference type="EnsemblBacteria" id="ABF88667">
        <property type="protein sequence ID" value="ABF88667"/>
        <property type="gene ID" value="MXAN_0814"/>
    </dbReference>
    <dbReference type="GeneID" id="41358280"/>
    <dbReference type="KEGG" id="mxa:MXAN_0814"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762498_0_0_7"/>
    <dbReference type="OMA" id="PADLMHP"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045430">
        <property type="entry name" value="EAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19955">
        <property type="entry name" value="EAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EAD1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="37810" checksum="FDED3A5F439ABA41" modified="2006-07-11" version="1">MELDGAERDELQRALTSAFASVEHLRRVVAATCRRDLEALGVSGGLRERVFALIHMAEAEGWLRELIRGVYQALPRHPRLQRFVQVYLASIQRSIPRVGLERIFGSGRADAEREHWRKRLTSIERQVCRVEPEVGAALGTGFLVSPSVVLTNFHVIENRLLESLRVRFGRKVLQDGTLLHPGTVYRVTRCLARSPYSPADLMHPRPRDATSGELDYAFLEVAGVPGEDLVDGEPRGWLEPPDSRESFTPGSLVLIVQHPAGQPMSVALDEFLGVNPGRTRVAYRACTGPGSSGAPCFTQDLRLAALHHSGGPRVPSASVGHNEGIPIDTIRGSLSGSMLSQLGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE71</accession>
    <name>Q1DE71_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88746">
        <property type="protein sequence ID" value="ABF88746"/>
        <property type="gene ID" value="MXAN_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0789"/>
    <dbReference type="HOGENOM" id="CLU_3120173_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="50" mass="5514" checksum="E6FB24BDF42E3D37" modified="2006-07-11" version="1">MTNLALNVSQFLDADVGTDQRDMLLGFIDEAVKSADRVDFSQDLKRIGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE82</accession>
    <name>Q1DE82_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550901.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0775"/>
    <dbReference type="EnsemblBacteria" id="ABF93101">
        <property type="protein sequence ID" value="ABF93101"/>
        <property type="gene ID" value="MXAN_0775"/>
    </dbReference>
    <dbReference type="GeneID" id="41358244"/>
    <dbReference type="KEGG" id="mxa:MXAN_0775"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743383_0_0_7"/>
    <dbReference type="OMA" id="SGTVWGF"/>
    <dbReference type="OrthoDB" id="1232664at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188433" evidence="3">
        <location>
            <begin position="36"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="386" mass="38468" checksum="030E40EED84D25BC" modified="2006-07-11" version="1">MADTCRRRASHTVTGAMTLATLILLATLSAQPSEAPPSSEATAPETVTAPPLVSTPDACAASSEADYSAGFDALVSGNDAKALELFERVLAACPQHPYATELARLSRTRLAPGGRLATGAASEMGREPYSSAARASLVVVQTLHGVAQGILLCAIGDCSGQGYAAVSLLGAGAGAASSLLLTRGGVTDGQAAVINSGTVWGFWFGIATLLAFDLDGDHAIGAAILGGAGFTGVGVLLAHLVNPTSGQVSLANSGGLWAGAVTALFLATSDNTDLKRFFAVELGATAAGILSMAILSKYVPVSRGRMLLIDAGGILGGLVGASALYLTAGNDAGDAILVGSGVGVLGGLALTTYLTRNFDLPDAPQVALAPLTTPRGGTGLSMVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DED8</accession>
    <name>Q1DED8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550845.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0717"/>
    <dbReference type="EnsemblBacteria" id="ABF89086">
        <property type="protein sequence ID" value="ABF89086"/>
        <property type="gene ID" value="MXAN_0717"/>
    </dbReference>
    <dbReference type="GeneID" id="41358190"/>
    <dbReference type="KEGG" id="mxa:MXAN_0717"/>
    <dbReference type="eggNOG" id="ENOG5032YXK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2448305_0_0_7"/>
    <dbReference type="OMA" id="AVYILCA"/>
    <dbReference type="OrthoDB" id="1994212at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046027">
        <property type="entry name" value="DUF5985"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19447">
        <property type="entry name" value="DUF5985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9307" checksum="A5CD9D47FC476626" modified="2006-07-11" version="1">MAEAVYILCALTSVACAVLLLRAYKRTGMRLLLWSGLCFVGLVVSNVLLFVDLVLLPATIDLYMPRAIATLSSASVLLYGLIWDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEG0</accession>
    <name>Q1DEG0_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QLH55566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550823.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0695"/>
    <dbReference type="EnsemblBacteria" id="ABF91459">
        <property type="protein sequence ID" value="ABF91459"/>
        <property type="gene ID" value="MXAN_0695"/>
    </dbReference>
    <dbReference type="GeneID" id="41358168"/>
    <dbReference type="KEGG" id="mxa:MXAN_0695"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_0_0_7"/>
    <dbReference type="OMA" id="NIDIAWI"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="321"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLH55566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="684" mass="78019" checksum="DEF24D1E708D330B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DER1</accession>
    <name>Q1DER1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0594"/>
    <dbReference type="EnsemblBacteria" id="ABF89005">
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        <property type="gene ID" value="MXAN_0594"/>
    </dbReference>
    <dbReference type="GeneID" id="41358072"/>
    <dbReference type="KEGG" id="mxa:MXAN_0594"/>
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    <dbReference type="OMA" id="MLDRTGN"/>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="1">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="27721" checksum="15DE51B7A7DA0334" modified="2006-07-11" version="1">MFTGPHGEAPPGRPCLPWAPRGTHLRTSLRREVDMTGRLGRAGGVAVLAALWGTGPLVGLTARAEAPQAGQTRDVLSARDLLLGQLALFDAKTIAAGNLALEKSANPQVRQFALRLVEDHRRHLQDLKAWGSSPSMDIVVADLTQPRTTAGIGGSGSKDGGLIPGPSLPMQRADARLEQAVAHAQQHLDVLRKAQGPDFDEAFLKRVIEDQEEALRLVKQAQATYKNDGAFTLMLDRTGNLADRHLQRAQGLKESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEU2</accession>
    <name>Q1DEU2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate-selective porin O and P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550694.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0562"/>
    <dbReference type="TCDB" id="1.B.16.1.3">
        <property type="family name" value="the short chain amide and urea porin (sap) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90247">
        <property type="protein sequence ID" value="ABF90247"/>
        <property type="gene ID" value="MXAN_0562"/>
    </dbReference>
    <dbReference type="GeneID" id="41358046"/>
    <dbReference type="KEGG" id="mxa:MXAN_0562"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040285_0_0_7"/>
    <dbReference type="OMA" id="WNWGRGP"/>
    <dbReference type="OrthoDB" id="1578713at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188562" evidence="2">
        <location>
            <begin position="42"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="457" mass="51259" checksum="66901409AD3A15AC" modified="2006-07-11" version="1">MRAFARCWQFRAVMTPTASFRAALQVLLSGSALLLAPLAHAQQDDAAPSSATEPPPASEPTPTPVPEAAMPEPETKPQAKKEERAWYDRIRIRGYTQFRYNRLPSFRVNDELVNDQGDRFLGKNTGFGIRRARLVLFGDVHDRVSIYLQPDFASVIGDQYNVTIMRDWYADIFLDAKKEFRLRVGQSKVPYGFENLQSSQNRLALDRNDAINSGLKDERDLGVFFYWAPDEIRKRFKFLVDNNLKGSGDYGVVGLGVFNGQTANRAERNDTPHGVVRVTWPFLFGSQYVEAGVGGYYGRFNLNASPRDGAPYALARGSDMVDARAIVSLVIYPQPLGLLAEFNLGRGPSLGEGPVEGLLIDSRRLRGGYAQLMYKLDGVLGVSLIPYIRGTLYDGGKKFETNAPLYDVRELEMGAEWQLNKALELTGTYLISDRTSSRYPYIQEQGHVTRIQLQVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF70</accession>
    <name>Q1DF70_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0433"/>
    <dbReference type="EnsemblBacteria" id="ABF87234">
        <property type="protein sequence ID" value="ABF87234"/>
        <property type="gene ID" value="MXAN_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0433"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265812_0_0_7"/>
    <dbReference type="OMA" id="CLDFCDD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="27149" checksum="161C9F8994B4AA06" modified="2006-07-11" version="1">MLGFPAEAFPGGCGMPVPKRSRSAARALARAGGTVSRDAQEEGVKQVYGEIASAYEVLFPALHRYEERVERFLAAVVAPGARVLDVGCGPGLHTRGLDASIAVVGTDLSEDMLALARTARPGGAWHVHSYHQPIPPDWGRFTVALAIGCLDFCDDLPRVLKHLAEALEPGGKLLFTVLERRPGLDGHEAPVQPIQTAGPAVTLHLYSFEETARAVAEAGLLPRTYAHAPGWVQLTEQRTMWFGWWEVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR5</accession>
    <name>Q1DFR5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88888">
        <property type="protein sequence ID" value="ABF88888"/>
        <property type="gene ID" value="MXAN_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0226"/>
    <dbReference type="HOGENOM" id="CLU_3390399_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="32" mass="3505" checksum="0D0B24CD98138371" modified="2006-07-11" version="1">MGLWLALARRIVDAHGGARCWSAGLAWGPPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT7</accession>
    <name>Q1DFT7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0204"/>
    <dbReference type="EnsemblBacteria" id="ABF87762">
        <property type="protein sequence ID" value="ABF87762"/>
        <property type="gene ID" value="MXAN_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0204"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_7_3_7"/>
    <dbReference type="OMA" id="TWTLCSI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="216" mass="23314" checksum="C14F97C60557D9FA" modified="2006-07-11" version="1">MGPEFRRIRGGLPGPRVSDEEAASMKALAYDAVMTPLGWLGLTAARRKLVRGLSGHVLEVGTGTGLALPGYPDTVTAVTAIDVDEAALARAQRRRPDARLLYASVESLPFPTASFDAVVSSLVFCSVEAPAQALTEIFRVLRPGGALRMLEHVRAPSPALATVQDLLTPAWMRVSGGCRLDRETFDLVRRAGFDIERRVQRLQGVSELIIARRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG58</accession>
    <name>Q1DG58_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acetyl-CoA carboxylase, biotin carboxylase</fullName>
            <ecNumber evidence="10">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accC</name>
        <name evidence="10" type="ORF">MXAN_0082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.4.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550229.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0082"/>
    <dbReference type="EnsemblBacteria" id="ABF88267">
        <property type="protein sequence ID" value="ABF88267"/>
        <property type="gene ID" value="MXAN_0082"/>
    </dbReference>
    <dbReference type="GeneID" id="41357589"/>
    <dbReference type="KEGG" id="mxa:MXAN_0082"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_7"/>
    <dbReference type="OMA" id="HLMGSKR"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="3"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="122"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="583"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="664" mass="70919" checksum="8A2BB112D1500C31" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q07765</accession>
    <accession>Q1CW48</accession>
    <name>DEVR_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>CRISPR-associated protein Cas7/Cst2/DevR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/Tneap</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Fruiting body developmental protein R</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">devR</name>
        <name type="synonym">cas7</name>
        <name type="ordered locus">MXAN_7262</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="7450" last="7462">
            <title>devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus.</title>
            <authorList>
                <person name="Thoeny-Meyer L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="7693658"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="J. Bacteriol." volume="189" first="3738" last="3750">
            <title>Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.</title>
            <authorList>
                <person name="Viswanathan P."/>
                <person name="Murphy K."/>
                <person name="Julien B."/>
                <person name="Garza A.G."/>
                <person name="Kroos L."/>
            </authorList>
            <dbReference type="PubMed" id="17369305"/>
            <dbReference type="DOI" id="10.1128/JB.00187-07"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>OPERON STRUCTURE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="function">
        <text>Has a role in fruiting body development, sporulation and aggregation.</text>
    </comment>
    <comment type="developmental stage">
        <text>Operon expression begins by 6 hours after starvation has initiated development and is under strong negative autoregulation.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Essential for sporulation, decreases sporulation 100 to 1000-fold, aggregation is defective.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CRISPR-associated protein Cas7/Cst2/DevR family. Subtype I-B/Tneap subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="L19029">
        <property type="protein sequence ID" value="AAA16134.1"/>
        <property type="molecule type" value="Unassigned_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B49941">
        <property type="entry name" value="B49941"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557181.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q07765"/>
    <dbReference type="STRING" id="246197.MXAN_7262"/>
    <dbReference type="EnsemblBacteria" id="ABF86719">
        <property type="protein sequence ID" value="ABF86719"/>
        <property type="gene ID" value="MXAN_7262"/>
    </dbReference>
    <dbReference type="GeneID" id="41364428"/>
    <dbReference type="KEGG" id="mxa:MXAN_7262"/>
    <dbReference type="eggNOG" id="COG1857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076037_0_0_7"/>
    <dbReference type="OMA" id="EMHTTEY"/>
    <dbReference type="OrthoDB" id="1098288at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016581">
        <property type="entry name" value="Cas7/Cst2/DevR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013414">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-B/Tneap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01905">
        <property type="entry name" value="DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011362">
        <property type="entry name" value="Fruiting_body_devlp_DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02585">
        <property type="entry name" value="cas_Cst2_DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0293">Fruiting body</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="chain" id="PRO_0000079871" description="CRISPR-associated protein Cas7/Cst2/DevR">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17369305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="7693658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="302" mass="32470" checksum="0A1CFD0D514A3161" modified="1994-10-01" version="1">MSLHVFAAFVTPLGTAANNRGLTEGNITSLQKLVWNGQVHTTVSAESIRFALRRRLNEQEPCNRTYDDASRANAWKDAAFSAWSGKSKEKTYIDDDLLGFMSAEGAKQEKEKGTAKVRRAVLEVSRAVSLTPWSGDVTFNAASPGATPSAQKKGSNPVPYGTEMHATRYQYGVALTPEALRVPARAVTALNQLCALGPVAGNHGRFLFDFSPESVVFRLTQEAAPRILYAFEPSSRAGGVELAALLRKVKSGDVPAKELVLGGQVVEGLGAEEREVLSGAELHTGVVAACRAACKRLEVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVF9</accession>
    <name>Q1CVF9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rnpA</name>
        <name evidence="6" type="ORF">MXAN_7511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557413.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7511"/>
    <dbReference type="EnsemblBacteria" id="ABF86797">
        <property type="protein sequence ID" value="ABF86797"/>
        <property type="gene ID" value="MXAN_7511"/>
    </dbReference>
    <dbReference type="GeneID" id="41364644"/>
    <dbReference type="KEGG" id="mxa:MXAN_7511"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_2_7"/>
    <dbReference type="OMA" id="RWVREIF"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="15800" checksum="E79A1BF5A57CBA60" modified="2006-07-11" version="1">MRAEGATPGQSRPADQRFPKALRLLQRREFLEVQEGGQKVPSDCLLALVKRNSRPYSRVGLTVSSKVGNAVVRARLRRVLRELFRKRRMQWPSGLDVVLVARSSAKDASFPALSRAFDGVTRKLQRLPRAAETKPKEPPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVG0</accession>
    <name>YIDD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_7510</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557412.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CVG0"/>
    <dbReference type="SMR" id="Q1CVG0"/>
    <dbReference type="STRING" id="246197.MXAN_7510"/>
    <dbReference type="EnsemblBacteria" id="ABF89292">
        <property type="protein sequence ID" value="ABF89292"/>
        <property type="gene ID" value="MXAN_7510"/>
    </dbReference>
    <dbReference type="GeneID" id="41364643"/>
    <dbReference type="KEGG" id="mxa:MXAN_7510"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_6_0_7"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000253128" description="Putative membrane protein insertion efficiency factor">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <sequence length="72" mass="8166" checksum="0F2C549BBC8FAA71" modified="2006-07-11" version="1">MSPLAFVISLPIRFYRKFLGPLLPKVCRFHPSCSTYAMEALEKHGGLKGSWLTLWRLVRCQPFHPGGIDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ8</accession>
    <name>Q1CVJ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557378.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7471"/>
    <dbReference type="EnsemblBacteria" id="ABF87996">
        <property type="protein sequence ID" value="ABF87996"/>
        <property type="gene ID" value="MXAN_7471"/>
    </dbReference>
    <dbReference type="GeneID" id="41364616"/>
    <dbReference type="KEGG" id="mxa:MXAN_7471"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_9_2_7"/>
    <dbReference type="OMA" id="LYEAQAW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="50746" checksum="CD0BB59039C4C207" modified="2006-07-11" version="1">MMFQMAEERSHPREEGGAHPPWKSRAWTELETARARVLAMLGGLPEDELRRQHSPLMSPLIWDVAHVANYEEQWLLRALGAPAITDPAFDAIYDAFRHPRSTRAELPLLPPEAAFAYARRVREAVREHLHRLPEDSTAPLLAGGYVFGMVAQHEQQHAETLAATLQLMTSPEYHVPSARPRPRPGAVPQAEVFIPGGEARLGSTSPWAYDNERPTFSQHVAPFLMDAHPVTNGDYLVFVEAGGYEDPRWWHPKGWEVIQAEGLKYPGFWLPQGNHTWLRRRFGQVEPLPKDEPVQHVCWYEADAYARWAGKRLPTEAEWEKAARGSDGRPREYPWGDTPPTRARANLDGSTWGPAPVGSYPQGVSQDGVWGLLGDVWEWTASDFRPYAGFSAFPYPEYSEVFFGESYKVLRGGAWASAPVAMRNGFRNWDFPNRRQIFAGFRCARNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVM8</accession>
    <name>Q1CVM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent DNA-binding response regulator Nla24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nla24</name>
        <name evidence="8" type="ORF">MXAN_7440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557348.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7440"/>
    <dbReference type="EnsemblBacteria" id="ABF90318">
        <property type="protein sequence ID" value="ABF90318"/>
        <property type="gene ID" value="MXAN_7440"/>
    </dbReference>
    <dbReference type="GeneID" id="41364589"/>
    <dbReference type="KEGG" id="mxa:MXAN_7440"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="MVITNAR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
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        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="145"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="451" mass="49236" checksum="9E16D7B07D43C7A0" modified="2006-07-11" version="1">MSTPRKRLLILDDDAGVVDFLCESLDARGYEAVGRTSPEEALALFERESFDLVITDVEMPRMRGTEVLEALLTRKPGQLVVLITAFGSVELAVAAVKAGACDFVTKPFNIDALVLTLERAFRERQLRREIVRLRAAVPGDTPGGLVARSSAMQKALEVSRRAARSDATVLLTGETGTGKSALARFIHESSGRRTQPFLQLNCAALPSGLAESELFGARRGAYTDAREDRAGVFVSVGGGTLFLDEVGELSLEVQAKLLQALETGRVRPLGSSTETPVRARVLAATNQPLEVLLREGRFRADLYYRLNVIRIEVPPLRERREDILPLVDFFLGRLGEQQQREVLGVSASALKRLLAHAWPGNVRELANLLERAVALADHDTLVPEDFDLPGGGESGLTSLLSHASGEDAPLEEVERAYVRRVVEAQGGNKAAAARILGINRRTLYRKLDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVR2</accession>
    <name>Q1CVR2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_7405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557316.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7405"/>
    <dbReference type="EnsemblBacteria" id="ABF93140">
        <property type="protein sequence ID" value="ABF93140"/>
        <property type="gene ID" value="MXAN_7405"/>
    </dbReference>
    <dbReference type="GeneID" id="41364561"/>
    <dbReference type="KEGG" id="mxa:MXAN_7405"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_7"/>
    <dbReference type="OMA" id="YPMIGSH"/>
    <dbReference type="OrthoDB" id="1746057at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="50"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF93140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="35498" checksum="5BE41B85E50406E3" modified="2006-07-11" version="1">MSTDATHLPRSALLFLARRPGLEDAAMRLRPFRRLASRFIAGETLEEAVDAVKALSARGLMASFDHLNEAVQTPEETREEVRQYQRLLARIDAVGVRANVSLKLTQCGLLFDEALALENARTVVAEAAARDSFVRIDMEDSSMTQVTLDIVRRLRAEFGEPHVGAVLQSALRRTEQDAKELCAQRIRIRLCKGAYLEKPDVAFPDKQDVDASFVRTMRVLLDSGVYHGIATHDERMIEATLDHAAKRGLPRGAFEFQMLYGIRRDLQERLVREGHPVRIYVPYGRHWYPYFMRRLAERPANLAFLLRNLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW02</accession>
    <name>Q1CW02_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan lytic exotransglycosylase</fullName>
            <ecNumber evidence="2">4.2.2.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Murein hydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_7308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exolytic cleavage of the (1-&gt;4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.</text>
            <dbReference type="EC" id="4.2.2.n1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557227.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7308"/>
    <dbReference type="CAZy" id="GH102">
        <property type="family name" value="Glycoside Hydrolase Family 102"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86934">
        <property type="protein sequence ID" value="ABF86934"/>
        <property type="gene ID" value="MXAN_7308"/>
    </dbReference>
    <dbReference type="GeneID" id="41364471"/>
    <dbReference type="KEGG" id="mxa:MXAN_7308"/>
    <dbReference type="eggNOG" id="COG2821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037751_1_1_7"/>
    <dbReference type="OMA" id="DQNGHPY"/>
    <dbReference type="OrthoDB" id="1529555at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14485">
        <property type="entry name" value="mltA_like_LT_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026044">
        <property type="entry name" value="MltA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034654">
        <property type="entry name" value="MltA_3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005300">
        <property type="entry name" value="MltA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30124">
        <property type="entry name" value="PTHR30124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03562">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019422">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00925">
        <property type="entry name" value="MltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188109" description="Peptidoglycan lytic exotransglycosylase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MltA" evidence="7">
        <location>
            <begin position="136"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="45263" checksum="CD1DFEA080622019" modified="2006-07-11" version="1">MDMRHLRILLLSALGLLASACPSPTRAPVTRPEDALIRLSRKMEPRDDGDVASLRTAVAESLVWLRSRPSDQRFIYGARQVSIAELRTALERLHARLREDLTPEALWALVLEDFEPLEAAGGEDGQVLFTGYYEPTIEASLTRTDVYNVPIHGPPSDLIEVPLESFAERFKSERVFGRLDGRKVVPYWSRGDIRGGRLSGRKLELAWAKDPVALFFLEVQGSGSLLLPDGSRRRIGYAASNGKPYRSIGSLLIQEGAIPKEEMSMQALRAWLAANPQQCHRVLDHNESYVFFRFLNTASVGSLGRPVTAGRSIATDARLFPKGGLAFIHTERPVRMADGSVQWKPLSRFVLNQDTGGAIRGAGRVDVFWGAGPQAELAAGMMKQKGRLLFLVPRPGRAAPLVAPVSVTPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD8</accession>
    <name>Q1CWD8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557091.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7173"/>
    <dbReference type="EnsemblBacteria" id="ABF92062">
        <property type="protein sequence ID" value="ABF92062"/>
        <property type="gene ID" value="MXAN_7173"/>
    </dbReference>
    <dbReference type="GeneID" id="41364346"/>
    <dbReference type="KEGG" id="mxa:MXAN_7173"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031793_0_0_7"/>
    <dbReference type="OMA" id="VRIAYFG"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="297"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="497" mass="51641" checksum="890FA6F12D451585" modified="2006-07-11" version="1">MTHSEVGRSGRRTWFPVLLGGLLTACDIGSSPRAATPPASAPEAPVVRPAEPPRPSPAPEVRRRMPVRPERTAEVQALAEKLGAPGAKVEDPCVAPLGNGCARTALAPFFASLDALATGTATRPVVIEAFGNSLIAGDRIVDVLRDDLATAFGSAGRGVLLVDRMAPYGGRGRTSASSSGWQPRTLGELRAPPHAFGVTGVYHVATNAKARSRFKLDGEPRGTLWWLDVPGAGAVSLSSGGKVLARTEPTGSGLSRATHFELPEDAQTLDVVAEGQGAVVQGVVLQHARPGIVLDTLGVPSSDASLYARIDGATLTSQLAERSPQLLVFFLGGNESKRIEWKRLDMEKLRTDLRALLRRAREAAPGSACLLVGPMDAVKGPGAKAQALTQRSSLEAVNAAEREVALAEGCAFFDFYAAMGGKGALARFHASGYMHDDLVHPRGAGLDVLGHLVTDALLRAYVETPPSARGVAAVMPTPSGAGAAPTGVSEPSAEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWK6</accession>
    <name>Q1CWK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase, M3 (Thimet oligopeptidase) family</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_7104</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7104"/>
    <dbReference type="EnsemblBacteria" id="ABF87039">
        <property type="protein sequence ID" value="ABF87039"/>
        <property type="gene ID" value="MXAN_7104"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7104"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_2_1_7"/>
    <dbReference type="OMA" id="WSSVIAK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="206"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="644" mass="72857" checksum="6A090E909F8151C5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR5</accession>
    <name>Q1CWR5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7045"/>
    <dbReference type="EnsemblBacteria" id="ABF87349">
        <property type="protein sequence ID" value="ABF87349"/>
        <property type="gene ID" value="MXAN_7045"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7045"/>
    <dbReference type="HOGENOM" id="CLU_1330755_0_0_7"/>
    <dbReference type="OMA" id="TGDIYWV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="23616" checksum="2BF60727D2403747" modified="2006-07-11" version="1">MAHGVHIDRLLMTLPIRKRLWAPCAAVLLVLGTACDGEDAPRDEACGEPLYGGDATDEAWRTFVDAQGRPTDSSQAVTLESPVPGQTYAMDAAPPIWRWTSPLASRLPSRETPHSMMAWLGNLLLPSAQAHLPPVTGDFYWVQVTVPGRRCPVELLTSNMEWQLDAATWDTLRAASGQDLRVQVTSAYLVQNRLREGPYRLESPRTIRVEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX40</accession>
    <name>Q1CX40_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556839.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6919"/>
    <dbReference type="EnsemblBacteria" id="ABF86810">
        <property type="protein sequence ID" value="ABF86810"/>
        <property type="gene ID" value="MXAN_6919"/>
    </dbReference>
    <dbReference type="GeneID" id="41364101"/>
    <dbReference type="KEGG" id="mxa:MXAN_6919"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_7_0_7"/>
    <dbReference type="OMA" id="YIELHIK"/>
    <dbReference type="OrthoDB" id="1834577at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="35375" checksum="AF11167B2A7FFA76" modified="2006-07-11" version="1">MAKVKHESDWYPLESGESVLDALLRQGVSIPNACRAGACQSCLMRAVAGTVPEAAQVGLKDTLRAQGYFLACACRPPEGTQLEVTGAEALRIPARIQALSLLSTSVLRVRLVTDSPLAYHAGQYISLVREDGLARSYSLASLPHEDALELHVRLQPGGAMSGWLAHDAQPGDRLQVQGPAGSCFYVPGRPEQPLLLAGTGTGLAPLYGIVRDALAAGHTGPIWLFHGARTPEGLYLTSELRALAEQHPQFLYRPGVLEGGSRDVAEGALDVLIRAECPKPLGWRAWLCGDGPLVLSLRKKLFLAGLSLKDLHTDAFLPSVPSGQRTSDAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA6</accession>
    <name>Q1CXA6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556775.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6850"/>
    <dbReference type="EnsemblBacteria" id="ABF88977">
        <property type="protein sequence ID" value="ABF88977"/>
        <property type="gene ID" value="MXAN_6850"/>
    </dbReference>
    <dbReference type="GeneID" id="41364039"/>
    <dbReference type="KEGG" id="mxa:MXAN_6850"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660270_0_0_7"/>
    <dbReference type="OMA" id="RCEPVGQ"/>
    <dbReference type="OrthoDB" id="958206at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="42366" checksum="5C8E8DE66223A5B4" modified="2006-07-11" version="1">MPPPRLAGRRAGNNLHVCHSTTEAWMKAKILAGAVAALMYGGVAVADDGDCPPPQASTSQSQQGTMVAQAQQEDPGGDDLLQEDDTIILETEPVPGVSGQQSQDSMGMGGSGQEGMDDAALGGSGQQPSNAQGEVYMNVPVRCEPVGQQGMGGSGRESMTPPPAAPQGTHDSEQLVVPPAPPLGTGGSGQPSSEPVYPEPESAYPPPKGGTGGSGIATTPPPSNFQPSAERAEPMKVEKHEDKNKIKGLSVMLGGGVEGYTGALAPQLSPGATAGVRASIKPSKVLGLELGYTGALNNIRRGETGASGPDLVRNGGQAVLTLGITPTAWQPYLLGGIGINDYNFRGGESLGYHDDTVGNVPAGVGLRGHVGHFVVDARANYNFLFDKDFAPGIDRGGDDFQGGGSYQGTVSVGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY4</accession>
    <name>Q1CXY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hyrolase, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556547.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6621"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88404">
        <property type="protein sequence ID" value="ABF88404"/>
        <property type="gene ID" value="MXAN_6621"/>
    </dbReference>
    <dbReference type="GeneID" id="41363819"/>
    <dbReference type="KEGG" id="mxa:MXAN_6621"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_0_2_7"/>
    <dbReference type="OMA" id="WQMAAEM"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="11"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="39685" checksum="88C11283565E56D3" modified="2006-07-11" version="1">MTTSSSLYRDCARLFMVGFPGTHIDSELAALMDDGIYGAILFKRNVGSAADTAALCHALKTRAGRPFILSVDQEGGRVARLRGAPFTALPPMRELGQRGDAAQVERVGRLLAYELRALGFDWDFAPVLDVDTNPANPVIGDRSFSREAEEVARLGVALARGLEAGGVASCGKHFPGHGDTTTDSHLTLPRLPHDLERLRSVELVPFRAFAQAGLASLMTAHVLFDALDPGVPATMSQRVLQGVLREELGFDGVLVSDDLEMKAIAGHYSVEEATVQGTLAGVDLFLVCHNADVQRRAIEALVKAVESGRVSRERIAQAHRRLDALSARFAHPAEDRLALLGSPEHHALAEGLVSTFTGRDPTEVMLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY96</accession>
    <name>Q1CY96_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556435.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6504"/>
    <dbReference type="EnsemblBacteria" id="ABF88434">
        <property type="protein sequence ID" value="ABF88434"/>
        <property type="gene ID" value="MXAN_6504"/>
    </dbReference>
    <dbReference type="GeneID" id="41363712"/>
    <dbReference type="KEGG" id="mxa:MXAN_6504"/>
    <dbReference type="eggNOG" id="COG4325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032303_1_0_7"/>
    <dbReference type="OMA" id="YVQHIDM"/>
    <dbReference type="OrthoDB" id="1749489at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018723">
        <property type="entry name" value="DUF2254_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10011">
        <property type="entry name" value="DUF2254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="472" mass="51393" checksum="82E62CA2A675E76F" modified="2006-07-11" version="1">MAEVLRMAGIQALPRTALGRGVPSSGPPRDAPPLRWWLRHRLWLTPVVGAVVGACLGVVFVDPPVFAARVLRGVAWQATSSEARDMLSTVLGIALTSLSIVLSLSMLVVQNAAGQFSPRLLRHFVHGAGIRVVIPVFVATSVFCLVATHEFGLVAGAERAPRPALSLAMLLLVVCEGALVFHVLHTLQSMRVENIVQRVRVDTLRVARRLERLRSGDLEAPAEVPAPTGGRWPLRAEQNGFVVSVDARRLLEVATARRLVVHLERAIGEPVIQGGEVGWFASDDRLSPASCEVAEALLLRAIHTDRWRDEDADVALGVRQLVDVAVKALSPGINDPYTVVEALDQLTFLMCELSQMRLGPRVVPDSSGRPRVFLRAPSLRDYLDLVTDQTLRYGATEPAVVLRLLRLAGAVGQHARQAETRRTARETLHRVLAATEQGQKDASWLAGIRRYAESLEQALEGKPLPPLPAIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYE5</accession>
    <name>Q1CYE5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556386.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88320">
        <property type="protein sequence ID" value="ABF88320"/>
        <property type="gene ID" value="MXAN_6455"/>
    </dbReference>
    <dbReference type="GeneID" id="41363661"/>
    <dbReference type="KEGG" id="mxa:MXAN_6455"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818415_0_0_7"/>
    <dbReference type="OMA" id="RPHAWVR"/>
    <dbReference type="OrthoDB" id="1188084at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="242"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="35676" checksum="AF9F946C8B4BB126" modified="2006-07-11" version="1">MATLLALLLLTLPVKPENPGSAGAPPASQADSTRYVFAWRGVPVGTVTLKLEPGRFTYVSQHLHTRAGKAGARRREQSLAVDAQGRVRGSPAVPQALWLWKGVPAVGCVVGREELTGREGPHCVTRVEDRRVEGTLLGTAFQARYGADGQMEALEVGDSRFTVAAPGERLRAPPELFADGLPVEGARGALSLEPPLDVPARPAGLTPWNAAAARALAAEVHAAFPEKTPGGADWSEDGEGEAGGCLAHALRFAAGARARGVKVALVHGLLVVDGGPARPHAWVRVALSKGGTLDLDPTSLDEVSPQTHLPIALAEAQGPALEAGARWLSLLRGAHRVVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYL2</accession>
    <name>Q1CYL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6387"/>
    <dbReference type="EnsemblBacteria" id="ABF86945">
        <property type="protein sequence ID" value="ABF86945"/>
        <property type="gene ID" value="MXAN_6387"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6387"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_1_7"/>
    <dbReference type="OMA" id="FMTRTCK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="28677" checksum="65623D997D6CF411" modified="2006-07-11" version="1">MLRLRRMLILILATFGSLYLVLCVVVFALQRSLLYPAPKGTPPLAESDGFSRLPLEGGLYVDLFHLPAPPGAPTVVHFHGNGEEVLTQMGLGSLMQARGLGFLTVEYPGYGASPGHPTEEGIYAAAEAALAWLRAKGVSAEQTVLSGRSLGTGVAVEMARRGHGSRVMLVSPYTSIPDIGATAFPFLPVRLLARDRYDTASKAAAVKLPVLIIHGEEDTLIPVDMGRRLGTLFPQAVVETVAGAGHNDVLEDPGKVYRHRMASFALGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYP5</accession>
    <name>Q1CYP5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556286.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6354"/>
    <dbReference type="EnsemblBacteria" id="ABF93132">
        <property type="protein sequence ID" value="ABF93132"/>
        <property type="gene ID" value="MXAN_6354"/>
    </dbReference>
    <dbReference type="GeneID" id="41363567"/>
    <dbReference type="KEGG" id="mxa:MXAN_6354"/>
    <dbReference type="HOGENOM" id="CLU_2106316_0_0_7"/>
    <dbReference type="OMA" id="WIERHYL"/>
    <dbReference type="OrthoDB" id="1815638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="14364" checksum="E0D9AC46CADB5D0E" modified="2006-07-11" version="1">MVLRIRPEQMACLDTSIRGTYVSSVVRFLRTQLPRESADLKERELRARAERGIDAAARHGITARWDVARFIACQLCLGEHFDTDPAHAWPQAVLARPYLTPSRKMDWIERHYLRPRRGRSPTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ57</accession>
    <name>Q1CZ57_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556129.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6185"/>
    <dbReference type="EnsemblBacteria" id="ABF85893">
        <property type="protein sequence ID" value="ABF85893"/>
        <property type="gene ID" value="MXAN_6185"/>
    </dbReference>
    <dbReference type="GeneID" id="41363414"/>
    <dbReference type="KEGG" id="mxa:MXAN_6185"/>
    <dbReference type="eggNOG" id="ENOG503309N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014571_0_0_7"/>
    <dbReference type="OMA" id="KMTNVIS"/>
    <dbReference type="OrthoDB" id="821646at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188190" evidence="1">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="30953" checksum="A16A9BEBE177B61B" modified="2006-07-11" version="1">MRFQRFAFAAMSFACTAAMAAEPIQPPWGKESNLGEKMMLEATSVCTDGKGHFVALTPDDEDTNAVLYYGDEKQFVQVPRPGPYTSATSFLDPRFFNKGANPNFRGIDWRVMSSVEIDRKERTCSLTCGEKKIPLTMLDGEPAAELLRKAAFQPNPQKFVPYALLRDTKGAYYFVDRGFHEAEKKNYRVFIGPRGNLKAQKMTNVISDSEGEIFSTKRGDLRLLLDKAKPAMWIENTKRRLELRQVPVDENLPLIYNELGVYEGARLGTPCDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZB2</accession>
    <name>Q1CZB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1800</name>
        <name evidence="3" type="ORF">MXAN_5207</name>
        <name evidence="4" type="ORF">MXAN_6127</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551905.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1800"/>
    <dbReference type="EnsemblBacteria" id="ABF86504">
        <property type="protein sequence ID" value="ABF86504"/>
        <property type="gene ID" value="MXAN_5207"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87870">
        <property type="protein sequence ID" value="ABF87870"/>
        <property type="gene ID" value="MXAN_6127"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89110">
        <property type="protein sequence ID" value="ABF89110"/>
        <property type="gene ID" value="MXAN_1800"/>
    </dbReference>
    <dbReference type="GeneID" id="41363360"/>
    <dbReference type="KEGG" id="mxa:MXAN_1800"/>
    <dbReference type="KEGG" id="mxa:MXAN_5207"/>
    <dbReference type="KEGG" id="mxa:MXAN_6127"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033141_3_0_7"/>
    <dbReference type="OMA" id="WRVERDY"/>
    <dbReference type="OrthoDB" id="699395at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="50856" checksum="BB62464ADD1F8F84" modified="2006-07-11" version="1">MTPAQLRKLDRELSEFLDSMTEGMGRTERRRALGGYLTGLLLDGERKSIEPMAARLVEAPEQTEAMRQRLQQCVSGAAWDDSEMRRRLARQLECELPGLEALVIDDTGLPKKGVHSVGVARQYSGTLGRTENCQVAVSLHVAGEKGSGCIAMQLYLPEEWTRSRKRCKAAGVPSGVKFQKKWQIALSQLDDAMAWSVRRHLVLADAGYGDAREFRDGVRERGLHYLMGVQGTHKVWPPGAKPRQPQRAPGQNGRPRTRYVAEGVQPWAIEELALQLPKEEFQTVYWREGSRGEQSSRFAAVRVRTAERHVQRAPPSEEVWLLIEWPQEEKAPTKYSLCSLPANTPLKELVRLSKLRWRVERDYQELKGEVGLDHFEGRGWRGFHHHATLCMVAHGFLALRRALFPPEESTLDTARSAPPPSAPAAAPHWPLPTLPAPHRRPRTSSGAVTHVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZJ4</accession>
    <name>Q1CZJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6044"/>
    <dbReference type="TCDB" id="1.B.14.10.3">
        <property type="family name" value="the outer membrane receptor (omr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89835">
        <property type="protein sequence ID" value="ABF89835"/>
        <property type="gene ID" value="MXAN_6044"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6044"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_16_0_7"/>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="641"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="682" mass="72616" checksum="CEB0379450D8A29B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZN9</accession>
    <name>Q1CZN9_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Kelch domain protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5999"/>
    <dbReference type="EnsemblBacteria" id="ABF86295">
        <property type="protein sequence ID" value="ABF86295"/>
        <property type="gene ID" value="MXAN_5999"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_5999"/>
    <dbReference type="eggNOG" id="COG3055">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01344">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
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        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="788" mass="80554" checksum="B40C1296B7AF0DD2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J0</accession>
    <name>Q1D0J0_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF90895">
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        <property type="gene ID" value="MXAN_5695"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="460"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="585" mass="65306" checksum="AC84E5E8C6C1D73F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q2</accession>
    <name>Q1D0Q2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5632"/>
    <dbReference type="EnsemblBacteria" id="ABF87805">
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        <property type="gene ID" value="MXAN_5632"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_5632"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5004188236" evidence="2">
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            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="16517" checksum="CC3E6270F9ADB9A1" modified="2006-07-11" version="1">MSRLALPTLLLALLTTACSEDLCTQAPRCDDSEALNCEPECKVGPCSSGPILQACTERTTCTVVPGDRNDARFYRSRAVCAVTLEACDPATAAPPTCGSDRFATGCSAYRRDIRVPCAQSALYFAQVPACCQGLGTGDGGTDAGTGDGDAGVPDAGTADAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D165</accession>
    <name>Q1D165_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555423.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5465"/>
    <dbReference type="EnsemblBacteria" id="ABF86601">
        <property type="protein sequence ID" value="ABF86601"/>
        <property type="gene ID" value="MXAN_5465"/>
    </dbReference>
    <dbReference type="GeneID" id="41362721"/>
    <dbReference type="KEGG" id="mxa:MXAN_5465"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_2_1_7"/>
    <dbReference type="OMA" id="MMAAIME"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="18520" checksum="8AAA259665D24D83" modified="2006-07-11" version="1">MRTHTEAIPYEVHRDDGLVASDDPARIDLDVVHGYLSRSYWSAGIPRETVERAARNSLVFGLYSSGGQVGYARVVTDRASFAYLCDVFVLEPYQGRGLGQWMMEALLEHPDLQGLRRFLLATRDAHSLYARCGFQPLGAPASFMERHDPDVYVRNREEGAKGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1A6</accession>
    <name>Q1D1A6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555382.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5420"/>
    <dbReference type="EnsemblBacteria" id="ABF91512">
        <property type="protein sequence ID" value="ABF91512"/>
        <property type="gene ID" value="MXAN_5420"/>
    </dbReference>
    <dbReference type="GeneID" id="41362682"/>
    <dbReference type="KEGG" id="mxa:MXAN_5420"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031758_4_2_7"/>
    <dbReference type="OMA" id="GPWQAPR"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="117"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="420" mass="44527" checksum="8746EDD8ADFF1618" modified="2006-07-11" version="1">MTDKELRMRQSVDSSRTSTPVELVNVTLPDGRCVDVLLRDGRIASIDEHRPDTGKSAHREATSIQLDGALLLPALVDGHCHLDKTFFGAPWQPHRAAGSIRQRTVDERALRNAVGVSVAQRATALANRMVSLGTGHIRSHVDIDPVGKLDGLHALFEVREAFRDRLGIQLVAFPQSGIVTAKGVADLLDAALSEGADLIGGLDPAGFDGDVDGQLDIVFGLADRHGSGIDIHLHDGGEVGTQQLRAIAERTKALGLSGKVAVSHAYALGQIDEHELARTAAALGAAGVAIMTNGPSRSMPPLRALREHGVRVFSGSDNIRDAWWPYGTADMLERATIIGLQAELMSDDDLKYASSLITDSAAEVLGITDYGLHPGCRADLVVIAASSVPEAVAAHPERLLVVHDGRVVGPVPGDGRARWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1C8</accession>
    <name>Q1D1C8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92513">
        <property type="protein sequence ID" value="ABF92513"/>
        <property type="gene ID" value="MXAN_5398"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5398"/>
    <dbReference type="eggNOG" id="COG4102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1883517_0_0_7"/>
    <dbReference type="OMA" id="GMETHHF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010869">
        <property type="entry name" value="DUF1501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07394">
        <property type="entry name" value="DUF1501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14498" checksum="1095E84A25ABDA2D" modified="2006-07-11" version="1">MDCVARFLGEMKASPAPGKPGKTLLDDTLVLVMSEFGRSWASRSSNGTYNLPDDHHPYTSVMFAGGNVAANRQVGTYTTRGLGVPVDIIEETGQTQKRVPRSAGVVTTALRIMGMETHHFFIPGGYGEVVGLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T4</accession>
    <name>Q1D1T4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5237"/>
    <dbReference type="EnsemblBacteria" id="ABF90246">
        <property type="protein sequence ID" value="ABF90246"/>
        <property type="gene ID" value="MXAN_5237"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5237"/>
    <dbReference type="HOGENOM" id="CLU_3101222_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="51" mass="5532" checksum="9B615D3F08BEA3B1" modified="2006-07-11" version="1">MDLRCGHPFVRVRFHTHTLDLQPGFGGGAVVGGVCLTPGCKKPDVRNVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2B3</accession>
    <name>Q1D2B3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555031.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5055"/>
    <dbReference type="EnsemblBacteria" id="ABF87875">
        <property type="protein sequence ID" value="ABF87875"/>
        <property type="gene ID" value="MXAN_5055"/>
    </dbReference>
    <dbReference type="GeneID" id="41362339"/>
    <dbReference type="KEGG" id="mxa:MXAN_5055"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_233682_0_0_7"/>
    <dbReference type="OMA" id="QCRRQQE"/>
    <dbReference type="OrthoDB" id="155273at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="856"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="1806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2014" mass="219398" checksum="FADCA1710B23D245" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D4</accession>
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            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_5034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
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        <reaction evidence="1">
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        </reaction>
    </comment>
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    </dbReference>
    <dbReference type="GeneID" id="41362319"/>
    <dbReference type="KEGG" id="mxa:MXAN_5034"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="QITHEIR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
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    </dbReference>
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        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
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            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
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            <end position="515"/>
        </location>
    </feature>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="515" mass="56859" checksum="7B5C4170D3184997" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2H2</accession>
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        <recommendedName>
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    </protein>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89467">
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        <property type="gene ID" value="MXAN_4995"/>
    </dbReference>
    <dbReference type="GeneID" id="41362279"/>
    <dbReference type="KEGG" id="mxa:MXAN_4995"/>
    <dbReference type="eggNOG" id="COG3148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="WQPYVVF"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DTW"/>
    </dbReference>
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        <property type="entry name" value="DTWD2/YfiP"/>
    </dbReference>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022694"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21278" checksum="457DC19FE8955EAD" modified="2006-07-11" version="1">MRSRTPEDLAGRCPRCFLPAALCLCAEVPCVSTRTELLIVRHHKETLKSTNTARMAALAIPRCNIVSYGSPGVPFDASILEGDDTWLLFPDAHHEPAPGAAFPSRLIILDGSWGQARRMVQRVPALRRLPGLKLPPPAPDSRRLRRPPHPDGMSTLEAIAGALAYLEGEHIAQPLHALHEQMIDRVLASRGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2K3</accession>
    <name>Q1D2K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4964"/>
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        <property type="gene ID" value="MXAN_4964"/>
    </dbReference>
    <dbReference type="GeneID" id="41362249"/>
    <dbReference type="KEGG" id="mxa:MXAN_4964"/>
    <dbReference type="eggNOG" id="ENOG5031UTB">
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    </dbReference>
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    <dbReference type="OMA" id="FEIIRPT"/>
    <dbReference type="OrthoDB" id="1421838at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="205" mass="21628" checksum="8359D80E9A036255" modified="2006-07-11" version="1">MVAIRKWVWGLLALTAACSGARQAVKHAGTGGSGPAPSAEAASEDSRSTTRRYVDEDLGFEIIRPTADWQLDETNERTPEGLAIPVILRHNVSGAQVVLQVAPAVASPTQFAERLTEGLRQHPGFTTTDPAPIPLSDTAVGFDFQVGDGVHGKVAVREGIPGRVLMMLATWPAQAAADVPQSVDALIQGVRPLAGPATAWKVPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L4</accession>
    <name>Q1D2L4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554931.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4953"/>
    <dbReference type="EnsemblBacteria" id="ABF89430">
        <property type="protein sequence ID" value="ABF89430"/>
        <property type="gene ID" value="MXAN_4953"/>
    </dbReference>
    <dbReference type="GeneID" id="41362238"/>
    <dbReference type="KEGG" id="mxa:MXAN_4953"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314696_0_0_7"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="929" mass="96349" checksum="AC9B54AC70918E7F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2N5</accession>
    <name>Q1D2N5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4932"/>
    <dbReference type="EnsemblBacteria" id="ABF92229">
        <property type="protein sequence ID" value="ABF92229"/>
        <property type="gene ID" value="MXAN_4932"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4932"/>
    <dbReference type="HOGENOM" id="CLU_3292842_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="40" mass="4453" checksum="7D8516E70669D423" modified="2006-07-11" version="1">MKKPARTKRAKTLKVTVRVLKVSALKAFETNVSSISHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2T8</accession>
    <name>Q1D2T8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554860.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4878"/>
    <dbReference type="EnsemblBacteria" id="ABF90854">
        <property type="protein sequence ID" value="ABF90854"/>
        <property type="gene ID" value="MXAN_4878"/>
    </dbReference>
    <dbReference type="GeneID" id="41362168"/>
    <dbReference type="KEGG" id="mxa:MXAN_4878"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="26150" checksum="5FE102969E01EA2E" modified="2006-07-11" version="1">MIEVQHLTKRYRDRVAVDDLTFQVEAGEILGFLGPNGAGKSTTMKILTGFLPPSEGVVRVGGYDVEAQPLEVKRRIGYLPEMPPLYVEMTVRGYLRFVASLKGLSGSALKAELERVAALMGVTHVMDRVIQNLSKGYKQRVGIAQALLGSPPVLILDEPTEGLDPAQRAELRALIKGLAGKHTVILSTHILPEVTMTCQKVLIIHQGKMAAYDDISQLARIHGQAENASLEEVFIKLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2U0</accession>
    <name>Q1D2U0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4876"/>
    <dbReference type="EnsemblBacteria" id="ABF90257">
        <property type="protein sequence ID" value="ABF90257"/>
        <property type="gene ID" value="MXAN_4876"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4876"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320248_0_0_7"/>
    <dbReference type="OMA" id="WMANGYE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="868" mass="92440" checksum="10BE2FB1807F5C18" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3H6</accession>
    <name>Q1D3H6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554624.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4631"/>
    <dbReference type="EnsemblBacteria" id="ABF87219">
        <property type="protein sequence ID" value="ABF87219"/>
        <property type="gene ID" value="MXAN_4631"/>
    </dbReference>
    <dbReference type="GeneID" id="41361931"/>
    <dbReference type="KEGG" id="mxa:MXAN_4631"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_4_2_7"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="OrthoDB" id="1255127at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="20851" checksum="6BCD77BEF209F138" modified="2006-07-11" version="1">MEVRSVCVFCGSRPGARPEYMDAATRMGAELARRGLTLVYGGASVGLMGAVADGALAAGGNVVGVLPGFLGAKELAHRGLTELHSVGSMHERKALMAERSDAFIALPGGFGTLDELFEIVTWAQLGLHRKPMGLLDTRGFFQPLLAMARHHAEEGFVPLEQAVPFAVSASPTALVDRLLAGPTMPPAEKWLKRSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K3</accession>
    <name>Q1D3K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554597.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4602"/>
    <dbReference type="EnsemblBacteria" id="ABF87535">
        <property type="protein sequence ID" value="ABF87535"/>
        <property type="gene ID" value="MXAN_4602"/>
    </dbReference>
    <dbReference type="GeneID" id="41361902"/>
    <dbReference type="KEGG" id="mxa:MXAN_4602"/>
    <dbReference type="HOGENOM" id="CLU_857444_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="324" mass="37148" checksum="E9FCFF36BA403BD0" modified="2006-07-11" version="1">MRKRIVEYVLPVQDEQSLLARIEQELRWYHNTHYAHLTAFLGVPHDNAQVRAQLEQIIGVFRDRKDSQKPDPNFKILSPVQPDASFVDLLTRLDCRLPKLMLLPHLTDHDNFSGLADSLRSTAALLRRYIIDFRFCITAERLPQTLPALLSELRKLSESPEDRALLSRFPVIEVPFTAGGDDSAQLANALAELWSRWPQLNDSVNLSRGGFVKHFYALKELWHLARIMNQEQSVEADIAKLRTGYGVEAAVEARIAAFDQAFLERYASLGQYNEWRHSSNSVVLEFDLDSIADTYECQSPVFVDNRWILERNSLELATDKGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3W0</accession>
    <name>Q1D3W0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Phage tail sheath protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554490.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4494"/>
    <dbReference type="EnsemblBacteria" id="ABF89179">
        <property type="protein sequence ID" value="ABF89179"/>
        <property type="gene ID" value="MXAN_4494"/>
    </dbReference>
    <dbReference type="GeneID" id="41361802"/>
    <dbReference type="KEGG" id="mxa:MXAN_4494"/>
    <dbReference type="eggNOG" id="COG3497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009303_1_0_7"/>
    <dbReference type="OMA" id="IFRIGQW"/>
    <dbReference type="OrthoDB" id="558210at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="505"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="680"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="794" mass="83947" checksum="FBEA251633BBFBD5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D463</accession>
    <name>Q1D463_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4387"/>
    <dbReference type="EnsemblBacteria" id="ABF88783">
        <property type="protein sequence ID" value="ABF88783"/>
        <property type="gene ID" value="MXAN_4387"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4387"/>
    <dbReference type="HOGENOM" id="CLU_1640902_0_0_7"/>
    <dbReference type="OMA" id="TTWSVVF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187859" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="16581" checksum="DF7BA50904EA3FC1" modified="2006-07-11" version="1">MMLGSILAMVLSAGGSADALAQVQVKNVSIQVPASWNRTEEGGTNKFQAPSGDAYFLVDVGAVQTAGMKAQTCVDKIVASIGGKGWERLKVGAQPAAKRQETDVAPDGSGAVDSVTYVGCDGKTTWSVVFYLEQTKKERFAPLAQKVGSSVKIQRAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4C8</accession>
    <name>Q1D4C8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554323.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4320"/>
    <dbReference type="EnsemblBacteria" id="ABF86997">
        <property type="protein sequence ID" value="ABF86997"/>
        <property type="gene ID" value="MXAN_4320"/>
    </dbReference>
    <dbReference type="GeneID" id="41361631"/>
    <dbReference type="KEGG" id="mxa:MXAN_4320"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_0_7"/>
    <dbReference type="OMA" id="REPREWS"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000002402">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="108" mass="11598" checksum="E0E5DF9DD96BEFD7" modified="2006-07-11" version="1">MTLRPYQDITPSQLDTLGPEVRRIDVREPDEYTGPLGHLPGAELIPLATLEAAASAWPREAPLLLICRSGGRSAQAARLLAHGGFKHLFNLAGGMLAVREPLAPRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="COG2010">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
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            <begin position="18"/>
            <end position="775"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="ABF92976.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="775" mass="84658" checksum="077F060C71BDC024" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
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    </reference>
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        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATP-grasp"/>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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            <end position="321"/>
        </location>
    </feature>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="729" mass="80307" checksum="69CFB25F659323AC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D520</accession>
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        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
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        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">MXAN_4075</name>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
            <strain evidence="6">DK1622</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2017" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Genomics-Guided Exploitation of Lipopeptide Diversity in Myxobacteria.</title>
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                <person name="Burgard C."/>
                <person name="Zaburannyi N."/>
                <person name="Nadmid S."/>
                <person name="Maier J."/>
                <person name="Jenke-Kodama H."/>
                <person name="Luxenburger E."/>
                <person name="Bernauer H.S."/>
                <person name="Wenzel S.C."/>
            </authorList>
            <dbReference type="PubMed" id="28128551"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DK 1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_4075"/>
    </dbReference>
    <dbReference type="GeneID" id="41361405"/>
    <dbReference type="KEGG" id="mxa:MXAN_4075"/>
    <dbReference type="eggNOG" id="COG0308">
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    </dbReference>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="3">
        <location>
            <begin position="869"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="APZ78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1200" mass="135264" checksum="6AA213744049AF53" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D547</accession>
    <name>Q1D547_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnaK</name>
        <name evidence="5" type="ORF">MXAN_4047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554055.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4047"/>
    <dbReference type="EnsemblBacteria" id="ABF92396">
        <property type="protein sequence ID" value="ABF92396"/>
        <property type="gene ID" value="MXAN_4047"/>
    </dbReference>
    <dbReference type="GeneID" id="41361378"/>
    <dbReference type="KEGG" id="mxa:MXAN_4047"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_0_7"/>
    <dbReference type="OMA" id="VSIIEIR"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="506" mass="55432" checksum="142BA6065AFE3A77" modified="2006-07-11" version="1">MHKEPIIGIDLGTTNSCAAIVEDSGNVKLIPYKGGEYTIPSIFAIDDKGNELIGYEAKRQWQLNPRNTVYGSKRLVGRGFGSEVVDTMKQVVAYNMRPGKQSDVILDVGKKEFALQEISAKILGKIREVASNYLKMPIKRAVVTVPAYFNDRQRQSVKDAGKLIDLEVVRIINEPTAAALAYGVGKGLKEKVVIYDLGGGTFDVSIIEIRDRVFEVKATGGDVFLGGIDFDNAIIHHVLKDFAAKTGLDLATDPVAMQRIKDLAERTKIDLSAREEVPFNIPFITMTSQGQPLNIEMKFSRKMLEQLTNQLVDRTLQMVARVLVDSGLSTKDVDEVMLVGGQTRMPIVQDRLTKFFGKPPSKGVHPDEAVAIGAALYAHSLQDDTNLRIQLLDVIPMAIGLEKAGGAFHTVFPRNASIPNAKQLLATTSMDNQTELAVRIFQGDNELVARNDMLGEFTFSGIQPGRAGAAQVEITFDVNVEGILTMRARDPASGREMKTTVRVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D599</accession>
    <name>Q1D599_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554004.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3994"/>
    <dbReference type="EnsemblBacteria" id="ABF85919">
        <property type="protein sequence ID" value="ABF85919"/>
        <property type="gene ID" value="MXAN_3994"/>
    </dbReference>
    <dbReference type="GeneID" id="41361326"/>
    <dbReference type="KEGG" id="mxa:MXAN_3994"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074793_0_0_7"/>
    <dbReference type="OMA" id="PVEHSHI"/>
    <dbReference type="OrthoDB" id="1643586at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="35818" checksum="530E35F06A50EA1D" modified="2006-07-11" version="1">MFLHPCLKDGLREYIVLALHEGLPNGYTLVTPARGWALERRLRQFAQDSSNQRTLQSLVYIHGHRSGMRAPLPVDEVVRQAALLLDSGVLRLAQAPPREAAVSPSFSVPQPGGVPVPVEEPVWLRLQVVDDTTDVPIAGIQLRIQLDDRSEHQARTDSEGRIDLKGVPKGGAHVLSDLEGATLDNTLALVRTGGPWSQQKPAKRGQRARGASGPRFLARVTQHRVIDGETLESVAEMYGLTVEELTRFNWNTTDAADIERHLILDVGCTRKGSRGQYVFTREDDPGILYVPRPEAIPRLPVEHSHILRVKRVPEPRHFLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K5</accession>
    <name>Q1D5K5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553898.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3888"/>
    <dbReference type="EnsemblBacteria" id="ABF88555">
        <property type="protein sequence ID" value="ABF88555"/>
        <property type="gene ID" value="MXAN_3888"/>
    </dbReference>
    <dbReference type="GeneID" id="41361221"/>
    <dbReference type="KEGG" id="mxa:MXAN_3888"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064479_1_0_7"/>
    <dbReference type="OMA" id="MLIGFRN"/>
    <dbReference type="OrthoDB" id="1222575at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022060">
        <property type="entry name" value="DUF3616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12275">
        <property type="entry name" value="DUF3616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="377" mass="39684" checksum="FCA81A6A33174FF9" modified="2006-07-11" version="1">MSDGAHCSMQAQGPVSRSTQTAPRHSPHGRGVAKSGAMRMLPVCMGVLVCGCAAHGVGERPDAVTAASMDGREVLRFEGMCDASGAVALGGSLFVVGDDEDNILRVYDARRGGPPVQSVDLSPDLELPAAKKKPPEADIEAATGLGSLSFWLTSHGRKSSGKKAPSRLRFFATKETDAGPRLVGRPYTQLLDDMLAAPQLARFGLDGAETKAPKAPGGLNIEGMTAMADGRTILVGFRSPVPDGKALLVPLLNPVALVEEGARAQLGEPVQLDLGGLGIRSLSWWRGRYVIISGGTAGEGTSRLFTWRGGEDAPVAVESVDLAGLNPEAFFTPEDTEEILLLSDDGAAPVDGVECKRLKDPSRKRFRGVWVRLPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L9</accession>
    <name>Q1D5L9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoredutase membrane subunit, NrfD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553884.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3874"/>
    <dbReference type="EnsemblBacteria" id="ABF89892">
        <property type="protein sequence ID" value="ABF89892"/>
        <property type="gene ID" value="MXAN_3874"/>
    </dbReference>
    <dbReference type="GeneID" id="41361207"/>
    <dbReference type="KEGG" id="mxa:MXAN_3874"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_7"/>
    <dbReference type="OMA" id="TWGNNIP"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="474" mass="53025" checksum="1EB435E6AAF2DB56" modified="2006-07-11" version="1">MSEPLPLAPVTADPLVVHPLLEERRPDAQLSEALLRPVLTAPGKGWWALVGVCAALTGLLVVAITITFATGVGTWGNNIPVAWAFGIINFVWWIGIGHAGTLISAILLLFGMKWRSSVNRIAEAMTLFALICAALFPLLHLGRPWKFYYLVPYPSSLRMWPQFRSPLTWDIVAVTTYLTVSVLFWYLGMVPDLATARDTAKQLWRRRVWGVLSLGWRGSARHWRHWRIGYLMLAGLATPLVVSVHTIVSFDFAVAQLPGWHSTIFPPYFVAGAIFSGLAMVLSLLIPARRALHLYTVVTQAHLDALARLLLVSGLFVAYGYVQEHFFGWYSGDPYEMHAMGMLRTGPYAPAFWTVFTCNVLVPQLFWSARMRTRPLVLWFAALLVNVGMWLERFVIIVSSLSEDFLPSSWRHYAPTWVDLSLLSGTVGLFGLGFLLFLRFLPPVPISEVKELQHQVEASEAFAHEVSAREGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Q2</accession>
    <name>Q1D5Q2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluB</name>
        <name evidence="6" type="ORF">MXAN_3839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553851.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3839"/>
    <dbReference type="EnsemblBacteria" id="ABF88468">
        <property type="protein sequence ID" value="ABF88468"/>
        <property type="gene ID" value="MXAN_3839"/>
    </dbReference>
    <dbReference type="GeneID" id="41361172"/>
    <dbReference type="KEGG" id="mxa:MXAN_3839"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015585_0_0_7"/>
    <dbReference type="OMA" id="WRAMMAQ"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="745" mass="77866" checksum="100E8D69A6372DE1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X1</accession>
    <name>Q1D5X1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3770"/>
    <dbReference type="EnsemblBacteria" id="ABF91185">
        <property type="protein sequence ID" value="ABF91185"/>
        <property type="gene ID" value="MXAN_3770"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3770"/>
    <dbReference type="eggNOG" id="COG3359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073770_0_0_7"/>
    <dbReference type="OMA" id="DLMYPCK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="89"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="33687" checksum="387889E4B5E58F40" modified="2006-07-11" version="1">MMLQRTFQHIPNVGPWREKDLWSRGIRTWDDFPEAGQGVALNRKSDDVARARIAEAKDALARRDLRKLAELLPGREHWRLYPEFQDDAVYFDIETDGREAQAPTVVSLFDSKGLHVFIQGRNMDALPEAMAARRLWVTFNGSCFDVPVLRDYFGPARFPVPDAHIDLRFVTRRLGMGGGLKEIEGKIGAERPPHMKGVNGYDAVLLWRAYQRRGDVEALRFLVEYNLYDAFQLRTLMDVAYNRGADDLNQDVPRLPVFERGDVLYDVSRIILELGPTERDLQTLARVRAMEQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D686</accession>
    <name>Q1D686_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3650"/>
    <dbReference type="EnsemblBacteria" id="ABF87931">
        <property type="protein sequence ID" value="ABF87931"/>
        <property type="gene ID" value="MXAN_3650"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3650"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="WRAACAN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="41"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="321"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="446"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="751"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="845" mass="89386" checksum="0302709188D0A6A5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6A1</accession>
    <name>Q1D6A1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-ribosomal peptide synthase/polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3635"/>
    <dbReference type="EnsemblBacteria" id="ABF89250">
        <property type="protein sequence ID" value="ABF89250"/>
        <property type="gene ID" value="MXAN_3635"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3635"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_21_2_7"/>
    <dbReference type="OMA" id="VAQFGSH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="914"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3245"/>
            <end position="3319"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4258"/>
            <end position="4333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2242"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2250"/>
            <end position="2273"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="949"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="4375" mass="470531" checksum="056566B17D870CD8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6K1</accession>
    <name>MEND_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="1">SEPHCHC synthase</shortName>
            <ecNumber evidence="1">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menD</name>
        <name type="ordered locus">MXAN_3528</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553558.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6K1"/>
    <dbReference type="SMR" id="Q1D6K1"/>
    <dbReference type="STRING" id="246197.MXAN_3528"/>
    <dbReference type="EnsemblBacteria" id="ABF88383">
        <property type="protein sequence ID" value="ABF88383"/>
        <property type="gene ID" value="MXAN_3528"/>
    </dbReference>
    <dbReference type="GeneID" id="41360872"/>
    <dbReference type="KEGG" id="mxa:MXAN_3528"/>
    <dbReference type="eggNOG" id="COG1165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006051_3_0_7"/>
    <dbReference type="OMA" id="FCNRGTS"/>
    <dbReference type="OrthoDB" id="897995at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032264">
        <property type="entry name" value="MenD_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16582">
        <property type="entry name" value="TPP_enzyme_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000341789" description="2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <sequence length="589" mass="61438" checksum="C4E167C01C88038D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6M8</accession>
    <name>Q1D6M8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integration host factor, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ihfB</name>
        <name evidence="5" type="ORF">MXAN_3501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553531.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3501"/>
    <dbReference type="EnsemblBacteria" id="ABF89893">
        <property type="protein sequence ID" value="ABF89893"/>
        <property type="gene ID" value="MXAN_3501"/>
    </dbReference>
    <dbReference type="GeneID" id="41360846"/>
    <dbReference type="KEGG" id="mxa:MXAN_3501"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_1_7"/>
    <dbReference type="OMA" id="FRASTEM"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="13765" checksum="C9BA11AD1BA45008" modified="2006-07-11" version="1">MTRSELIERIVERATHVPRREVEAIVHAVFEEMSQALIAGRRIELRGFGVFCVRTRRARTGRNPKTGQRVSVPARRTLSFAAGKDLRERLNAPPAMAASPVPDTPPGEALSPLPLAAGASFSVPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S6</accession>
    <name>Q1D6S6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding heavy metal response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553483.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D6S6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3450"/>
    <dbReference type="EnsemblBacteria" id="ABF87509">
        <property type="protein sequence ID" value="ABF87509"/>
        <property type="gene ID" value="MXAN_3450"/>
    </dbReference>
    <dbReference type="GeneID" id="41360798"/>
    <dbReference type="KEGG" id="mxa:MXAN_3450"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_7"/>
    <dbReference type="OMA" id="LMLTARC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="121"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24793" checksum="A1DAFAB7C62AF875" modified="2006-07-11" version="1">MRLLLVEDEERMANLLRRGLGEEGHLVDTCRTAEDALDQAGEVAYDAIILDWALPGMDGVALLRRWRERGLMTPVLMLTARGTVGERVTGLRAGADDYLVKPFAFEELLARLEALHRRSEGQTQSWGGGAIHIDARRRMLTCGDREVALTGREFALLGELASRAGEVHTRSSLLAKVWGPSFDGPPNIVDVYVGYVRTKLTEVGAEGVTIQAVRGVGFRLVIEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6U8</accession>
    <name>Q1D6U8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF92374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3428"/>
    <dbReference type="EnsemblBacteria" id="ABF92374">
        <property type="protein sequence ID" value="ABF92374"/>
        <property type="gene ID" value="MXAN_3428"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3428"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_0_7"/>
    <dbReference type="OMA" id="NTVHAAT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="793" mass="88497" checksum="F2FD3706FEFFFCF5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D704</accession>
    <name>Q1D704_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553405.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3372"/>
    <dbReference type="EnsemblBacteria" id="ABF88895">
        <property type="protein sequence ID" value="ABF88895"/>
        <property type="gene ID" value="MXAN_3372"/>
    </dbReference>
    <dbReference type="GeneID" id="41360719"/>
    <dbReference type="KEGG" id="mxa:MXAN_3372"/>
    <dbReference type="eggNOG" id="COG5373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620852_0_0_7"/>
    <dbReference type="OMA" id="TYHLQEN"/>
    <dbReference type="OrthoDB" id="889774at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030820">
        <property type="entry name" value="OMP_myx_plus_Proteobacteria"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04565">
        <property type="entry name" value="OMP_myx_plus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187950" evidence="2">
        <location>
            <begin position="18"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="442" mass="46978" checksum="BDC4FA54BAC7DFFA" modified="2006-07-11" version="1">MRPFLSLALLVATATQAAPRVPAPAFALAQVQQVPAPGAETSVPPPSTQSQSLPEAPVGPASRPEPLVPAEATEAFAPPAGVRPNAAPAQGSDEVPASEPSRVDDTAPVPSAEPAPTVGTDPAPATTGMAGQEAPPVPDDAPMLASDLGSDAPRTTDAQQQRLVNGAPLYNPNVSVHIVQKKRFADEGRHELTVYPATVQVNGKYTDHAGTAAHYTYHLQENFALQVMGQYNWYSNESAFNLELIDKVREQAQAASSLLLVWGAHAGVEVTPLYGKFAFLNNSLAQFSVVLSGGAGVGSTRHLIRPAVTNDVEGESFRVPARFGDTGTKFMGSVGGGFRLQFGESYALRVEVRDLIYTARVDRVDGCNLADFEALEAARSTNQDFASLNLSGSCRYEKFDGIDPKTKKNYREDIILGRDLVVEPSSDVLNNVSFYAGFSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D740</accession>
    <name>Q1D740_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter, drug/metabolite exporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553369.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3334"/>
    <dbReference type="TCDB" id="2.A.7.3.40">
        <property type="family name" value="the drug/metabolite transporter (dmt) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91499">
        <property type="protein sequence ID" value="ABF91499"/>
        <property type="gene ID" value="MXAN_3334"/>
    </dbReference>
    <dbReference type="GeneID" id="41360687"/>
    <dbReference type="KEGG" id="mxa:MXAN_3334"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_2_7"/>
    <dbReference type="OMA" id="LWMTGLK"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="31179" checksum="28577B41150FDBE7" modified="2006-07-11" version="1">MSTPTTAVVPAPSRGISASDLAIVGVVIAWGTNYTVVKEAMETLPPLAFMSLRFTIAALAMGALLLGVEGWKPLPRPVFLKLLGLGLVGNTVYQVCFIVGLANTSVANSGMLTAVTPVLVATLGAVFGVDRLTRPLIAALALGVVGMLLVLGGRGASEHGASLIGDGLIVGASLCWAIYTVGIRTVGPEVSALRITAISMLTGAPGVVLVGVPELLRLETENIRAGAWAGVVYSALVPLVLAYFTWGRTVQKVGSSRAGLYNTGIPVVAALTAWAVRGEQPTWMQVLGAGLVLSGVLLSRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A5</accession>
    <name>Q1D7A5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ORF">MXAN_3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3269"/>
    <dbReference type="EnsemblBacteria" id="ABF92347">
        <property type="protein sequence ID" value="ABF92347"/>
        <property type="gene ID" value="MXAN_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3269"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_2_1_7"/>
    <dbReference type="OMA" id="HFLPMNI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="88" mass="9289" checksum="5159A2CACEAFDDFC" modified="2006-07-11" version="1">MTARSHPCSACPGPVVARSREAMQVWVNGETHEVPEGTTLSALLESLQVGGPGVAVEVNAEVVRRARHPEHHLQAGDRVEIVTFVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F0</accession>
    <name>Q1D7F0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553269.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3224"/>
    <dbReference type="EnsemblBacteria" id="ABF85876">
        <property type="protein sequence ID" value="ABF85876"/>
        <property type="gene ID" value="MXAN_3224"/>
    </dbReference>
    <dbReference type="GeneID" id="41360578"/>
    <dbReference type="KEGG" id="mxa:MXAN_3224"/>
    <dbReference type="HOGENOM" id="CLU_206562_0_0_7"/>
    <dbReference type="OMA" id="GTGAMTW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="81" mass="8071" checksum="AF90405AC5987939" modified="2006-07-11" version="1">MKSTTRDEFARTGDGRMRKAAGAVAASFAMGTGAMTLMGVAFATQMEAAVVAVVGLALYASSALLTNKAPATAATSVAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7K4</accession>
    <name>Q1D7K4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3166"/>
    <dbReference type="EnsemblBacteria" id="ABF89020">
        <property type="protein sequence ID" value="ABF89020"/>
        <property type="gene ID" value="MXAN_3166"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3166"/>
    <dbReference type="eggNOG" id="ENOG502Z7YZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071811_0_0_7"/>
    <dbReference type="OMA" id="GYWTTVK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="37700" checksum="C75CFA2AA0D24A91" modified="2006-07-11" version="1">MTRVSFRATFRARRCADVMHEGSPPWTHTLRRTRPGRPAHRAGCGWGVLPAPSCPRLNSPYRPESHIARQGKTPCCVEGDNPLFRKIGSTVMPKLNQIIAVEKGVKNRSQQELTQAHHDLQKPQLLSGISRTYQPRDEEGERFPPESTRVQVRTQDVLKKTQEILTRLFDVTATKDLTNCHAKADVRVDGRVLLKGVPATYLLFLEKQLVDLHTFVKKLPTLDPSESWVPDPAQGLWATEPVQTAKTKKVPRNHVKSEATEKHPAQVEVYYEDIVVGYWKTVKFSGALPATRMNDLLERVEKLQQAVKFAREEANAVEVEEMKAGEALLGYLFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Y6</accession>
    <name>PYRD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="1">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DHOdehase</fullName>
            <shortName evidence="1">DHOD</shortName>
            <shortName evidence="1">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrD</name>
        <name type="ordered locus">MXAN_3028</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553084.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7Y6"/>
    <dbReference type="SMR" id="Q1D7Y6"/>
    <dbReference type="STRING" id="246197.MXAN_3028"/>
    <dbReference type="EnsemblBacteria" id="ABF92496">
        <property type="protein sequence ID" value="ABF92496"/>
        <property type="gene ID" value="MXAN_3028"/>
    </dbReference>
    <dbReference type="GeneID" id="41360390"/>
    <dbReference type="KEGG" id="mxa:MXAN_3028"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013640_4_0_7"/>
    <dbReference type="OMA" id="ERIKMGA"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86006.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="141" mass="15234" checksum="F54BF85D191CED91" modified="2006-07-11" version="1">MLQCRPLVPRREKTMGSFQQFLTDKNIPTEKLLRLSRQLESYGSEGRTLLKKRSARRRDKDTQGKSYESLSIGKPKSGRGISAQQLQAALGDLPLTASVRGKLVRAVNAVLGKQGGSPVDAPALFGASPVRRGATAKKSAS</sequence>
</entry>
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        <submittedName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Eisen J.A."/>
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                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="51317" checksum="A17A17789FB70502" modified="2006-07-11" version="1">MNLHDYSRFDAVGLAELVRRKEVTPEELLRVAVEAIHAVNPALNAVIDTREGDASEALKQGIPEGPFRGVPFLIKDIGLHAAGVPTDMGSRMAQGTVFPHDSALMARYRRAGLVLLGRTNAPEFGNNATTEPVLHGPTRNPWDVKRSPGGSSGGSAAAVAAGIVPVAHGNDGGGSLRIPAALCGVFGLKPTRGRNSLGPDAGDFIFGMGIEHVLSRSVRDSAAMLDATQGPEVGDPYFAPPPQRPYLEEVGRAPGRLRIALMTEAPMGSPASAECVEAARAAARLCTELGHDVVEAAPEHDGQLLHEAVCTVWSATMASLVGMLGQFSGRDPGPELLEATTWAAVRHGRELKATDLQRALGVFNLVSRQVGAFFQQYDVLLSPTVAAPPFPLGLLDANAPRTAREWYDHAFGHCPFTALFNVTGQPAMSVPLHWSAEGLPIGVQFAGRYAAEATLFQLAGQLEQARPWAQRTPPVHVTRPAESP</sequence>
</entry>
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    <accession>Q1D8J2</accession>
    <name>Q1D8J2_MYXXD</name>
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        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
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        </recommendedName>
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        <name evidence="5" type="ORF">MXAN_2814</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
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        </reaction>
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        <property type="protein sequence ID" value="ABF86987.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="PRERDWQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14488">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM6/CBM35/CBM36-like_2"/>
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        <property type="entry name" value="FN3_dom"/>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
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        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="433"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="867" mass="90930" checksum="4BF43D36519CB716" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8M0</accession>
    <name>Q1D8M0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hppD</name>
        <name evidence="7" type="ORF">MXAN_2786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552853.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2786"/>
    <dbReference type="EnsemblBacteria" id="ABF89344">
        <property type="protein sequence ID" value="ABF89344"/>
        <property type="gene ID" value="MXAN_2786"/>
    </dbReference>
    <dbReference type="GeneID" id="41360162"/>
    <dbReference type="KEGG" id="mxa:MXAN_2786"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_1_0_7"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="OrthoDB" id="402639at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="160"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="39807" checksum="C14DB26F4240FC69" modified="2006-07-11" version="1">MADTAENPLGLNGFEFVEFTSPQPEVMEHLFERLGFTAYSKHPSKELVRYKQGGINLLINREASGQAAEFRAEHGPSASGMAFRVANARTAYEMALERGAKAADPERGSLGEGSYVLEGIGGSLLYLVDRHGEKGTLYDSWQEIPGAEAAEAKNSVGLETLDHLTHNVRRGQMRTWSSFYNRIFGFTEQKYFDIKGQATGLFSQAMIAPDKAIRIPLNESQDDKSQIEEFIRQYKGEGIQHLALTTPDIYDTVERLRARGVVLQDTLETYYDLVDKRVPKHGEDLARMRKNRILIDGSEEEGLLLQIFTENLFGPIFFEIIQRKGNEGFGNGNFQALFESIELDQIRRGVIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P2</accession>
    <name>Q1D8P2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552831.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2764"/>
    <dbReference type="EnsemblBacteria" id="ABF87651">
        <property type="protein sequence ID" value="ABF87651"/>
        <property type="gene ID" value="MXAN_2764"/>
    </dbReference>
    <dbReference type="GeneID" id="41360141"/>
    <dbReference type="KEGG" id="mxa:MXAN_2764"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717115_0_0_7"/>
    <dbReference type="OMA" id="RYEITPR"/>
    <dbReference type="OrthoDB" id="821623at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="393" mass="41782" checksum="F80125E7DAC87698" modified="2006-07-11" version="1">MHLRGAPHPMIRAARRSLAASLVALLAAGLFVVPGWLQGLSLVVRAAGMQGRVETALADWRTGPFDVSDVQVPTRHGPVRARLYRPVTQRGRTVVLTSGVHADGIDEPRLVKLAEDLAMGGQAVLTPEPPDLLRYEITPRLPDIIEDAAVWAASQADLAPDGKVNLFGISFSGGLSVVAAGRPALQDRVAATLSFGGHGDLPRVLTFLCSGDLPDGSHLAPHDYGVVIILLNVAEMLVPPEQVEPLRAGIRTFLRASHQAMVDGRLAAETFAKARDLQAELPEPAATLMGYVNTRDVAALGPRLLPFVKTFAADPALSPERSPPPTAPVFLLHGAGDTVIPAMESSRLAAALRPHTEVNALATPLITHAEMDGPQALMDVLRLVHFWADLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M3</accession>
    <name>Q1D9M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552505.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2430"/>
    <dbReference type="EnsemblBacteria" id="ABF91151">
        <property type="protein sequence ID" value="ABF91151"/>
        <property type="gene ID" value="MXAN_2430"/>
    </dbReference>
    <dbReference type="GeneID" id="41359814"/>
    <dbReference type="KEGG" id="mxa:MXAN_2430"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="EGTTMLM"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="26693" checksum="C8B2FC5DBCCADD92" modified="2006-07-11" version="1">MNPTASQSSIVSITNVTKDYTLGKVVVPALRGVDLEVHAGEFISIAGPSGSGKTTLLNLIGCVDTATGGVVRVAGQDTKQLTERQLTNLRLNTIGFIFQSFNLVQVLSVFQNVEFPLLLQRKLDKAQRRERVMQLLEQVGLASHAKHRPNELSGGQRQRVAVARALVTRPQLVLADEPTANLDSVTGQNIIDLMKELNQKEGTTFIFSTHDAKVMSHANAVVRLADGKFLDRISAAEASRAMASGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9P7</accession>
    <name>Q1D9P7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552481.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86687">
        <property type="protein sequence ID" value="ABF86687"/>
        <property type="gene ID" value="MXAN_2406"/>
    </dbReference>
    <dbReference type="GeneID" id="41359790"/>
    <dbReference type="KEGG" id="mxa:MXAN_2406"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885146_0_0_7"/>
    <dbReference type="OMA" id="HYEQLPF"/>
    <dbReference type="OrthoDB" id="1036682at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="34842" checksum="E2B64CE5D77ED1C1" modified="2006-07-11" version="1">MGLACRATRAGLRAVAFTSCFIGGAVLPSRPALALVSVLSSLALFVGPAEARAQGRSLPSFNLQRLELDPAALGSLMVGTGRTLPQGALRMSVQGHYEQLPFTFQRRWEPGSGRGLVEDRFTMDLTAAYGVLPWLQVAAEVPFIVTQGGTRFRDFNAPEGSGMGTPWLGLRAALKRQDFGFQMAADVSAALPVGSTALLARDDYAVHPRLQVGFLAETWQVGGEAGVLVRKKHELSSVSGFSQDVIGSELRLGATVTSRAGESTRGEVSLVAGLPLQGGRPGGELLLAIRKHALSWLDLYVLGGPGVGAGMDTPTFRFVAGASFSTFRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9U1</accession>
    <name>Q1D9U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552437.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2362"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88906">
        <property type="protein sequence ID" value="ABF88906"/>
        <property type="gene ID" value="MXAN_2362"/>
    </dbReference>
    <dbReference type="GeneID" id="41359747"/>
    <dbReference type="KEGG" id="mxa:MXAN_2362"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_7"/>
    <dbReference type="OMA" id="FDWGAFH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="210"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42808" checksum="6DDE365116D7C552" modified="2006-07-11" version="1">MLVTTQGEAPPVAARKRVLFTLVFLGSGGIERSVCNVLTGLDPSQFDTKMFFHHRPHPKSQSDRIPQRTEVVWGTDAFEYRRGMLPRFFWRLVREARDVDVIVAGQEGRAALLACLAGRLLRKPVVGMIHFDWGAFHLEQPRRQLWGLRWLYPRMSRIVACGHDSAKAFRDLVPVRPEQLHVIPNFVDGDRVRAAGEHPLPAWAEPIFRKPVVIAVGRLEHQKAFDVLIRSHALMRQAGVDQHLLILGEGSLEAELKALVKSLGVEDSVFLPGFAPNPHALMRRAAAFALSSRFEGLPMVLLEALALGCPVVSTDCPSGPAEVLEHGKHGVLVPMEQPQALADALARIVQDDVHRADLSARARRRSEELSADRALKAWESLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V2</accession>
    <name>Q1D9V2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552426.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2351"/>
    <dbReference type="EnsemblBacteria" id="ABF86018">
        <property type="protein sequence ID" value="ABF86018"/>
        <property type="gene ID" value="MXAN_2351"/>
    </dbReference>
    <dbReference type="GeneID" id="41359735"/>
    <dbReference type="KEGG" id="mxa:MXAN_2351"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_7"/>
    <dbReference type="OMA" id="YGICELC"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="138" mass="15017" checksum="D6EB3B47BAAEC534" modified="2006-07-11" version="1">MRIGELMTKNLETIEAGEPIRAAALRMRTCNIGSLPVLEGGQLVGMLTDRDIAVRSAALGQDPNTTPVREVMTATVITCDVDATLEVAEKVMEEKMVRRLVVVDGERRPVGLLSLDDLATVPEEVLHAGEVLERLQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA07</accession>
    <name>Q1DA07_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552371.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2295"/>
    <dbReference type="TCDB" id="2.A.1.86.1">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91426">
        <property type="protein sequence ID" value="ABF91426"/>
        <property type="gene ID" value="MXAN_2295"/>
    </dbReference>
    <dbReference type="GeneID" id="41359682"/>
    <dbReference type="KEGG" id="mxa:MXAN_2295"/>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008530_0_0_7"/>
    <dbReference type="OMA" id="HLMTREY"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="420"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="731" mass="77769" checksum="01A73EF71190821E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA29</accession>
    <name>Q1DA29_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="7" type="ORF">MXAN_2273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF87542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552349.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2273"/>
    <dbReference type="EnsemblBacteria" id="ABF87542">
        <property type="protein sequence ID" value="ABF87542"/>
        <property type="gene ID" value="MXAN_2273"/>
    </dbReference>
    <dbReference type="GeneID" id="41359661"/>
    <dbReference type="KEGG" id="mxa:MXAN_2273"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_7"/>
    <dbReference type="OMA" id="RFHDCAH"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
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        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="107"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="113"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="204"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="38819" checksum="8332762C3E27450C" modified="2006-07-11" version="1">MSLETLGWGPAFEHAFSTLVSQSPLSLVPGRVVRQHRGLLTVQTDTRTLLARTAGRLLHQAPGVESLPTIGDWVALQLPDGDGEALLHAVLPRASVLARREAGSERDGQLIAANLDVVVLVAGLDGNFNPRRIERALALAWTSGAAPVVVLTKADLRPDADSLVAEVEELAPGVPVLALSSWTGEGIEALRAQLPAGKTGALLGSSGVGKSTLVNRLLGEARLVTQAVRAEDDKGRHTTTHRELFVLPGGGLLIDGPGMRELGLWGEDDGIGQTFTDILELAAGCRFTDCQHQREPGCAVRAAVSSGALPEARLASYERLRREQAYQVRQRSASAERDHRRHERGRTLMGWEASRSKRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAE2</accession>
    <name>Q1DAE2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2158"/>
    <dbReference type="EnsemblBacteria" id="ABF86348">
        <property type="protein sequence ID" value="ABF86348"/>
        <property type="gene ID" value="MXAN_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2158"/>
    <dbReference type="eggNOG" id="ENOG50323EY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079332_0_0_7"/>
    <dbReference type="OMA" id="CASFAPC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dickkopf_N" evidence="1">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="31544" checksum="CB30180C5F90E6FB" modified="2006-07-11" version="1">MPVLARFPRHQVLGGSGASCNPVESGRFDVSRGLGTHVAQVLPIARRRRTATVQMNLTETTMKHVVMGLFLALTVMGCGSTKDDDGEGPDGNPNEQSAGLCSASKACPSGQFCFNGLCAIGCQSNGDCAADQYCDLEDTGMAVSFCKNKKVPTCSSNSQCLSNQVCIEGLCSLAPPANPPSCNPNTSDFKDGCDTYAVCLDAADQGSQQPYCASFAPCPEDGVCPTGLGGAVCNDGYLPNKGRFCMQGLCSDNSNCPSAWSCVKPFSGAVLGFCSPGAFGFPCAENSHCKSGQCFSAPGVMGTCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG0</accession>
    <name>Q1DAG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552218.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2140"/>
    <dbReference type="EnsemblBacteria" id="ABF89760">
        <property type="protein sequence ID" value="ABF89760"/>
        <property type="gene ID" value="MXAN_2140"/>
    </dbReference>
    <dbReference type="GeneID" id="41359539"/>
    <dbReference type="KEGG" id="mxa:MXAN_2140"/>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057081_0_0_7"/>
    <dbReference type="OMA" id="YTSSPGD"/>
    <dbReference type="OrthoDB" id="589228at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="37176" checksum="F35F200F846E58C3" modified="2006-07-11" version="1">MTISVRCVLRHHFRHFNARTLVDAADAWAAHADDGGKMMVTLAGAMSTAELGISLAEMIRRDKVHAITTTGANLEEDVFNLVAQEHYVRVPDPRSLTAEQEAELRDKGLNRVADTCIPEEEAMRKVERPLLELWQRAERDGRRHFPHEYLYELLLSGALAGSYQVDPRHSWLLAAAEKRLPIFVPGWEDSTLGNVFVASVMRKELETWSPIRGGAEYMAALADWYRETSSSAKVGFFQIGGGIAGDFPICVVPMLRLDLEEEVPYWSYFCQISDSTPSFGSYSGAPPNEKITWHKVDVDTPRFVIESDATIVAPLVFSYVLDCWGVRQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAS3</accession>
    <name>Q1DAS3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552105.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2021"/>
    <dbReference type="EnsemblBacteria" id="ABF93002">
        <property type="protein sequence ID" value="ABF93002"/>
        <property type="gene ID" value="MXAN_2021"/>
    </dbReference>
    <dbReference type="GeneID" id="41359431"/>
    <dbReference type="KEGG" id="mxa:MXAN_2021"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="EFAVRNK"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16927" checksum="148D77F5097FBABC" modified="2006-07-11" version="1">MSLTPSEELATFTELDTREREERTDLLKLEPARAAVLVVEDDPSHREILVEMLAGWGYEPLPVGSAEEAEFAVRNKRMDAAIVDVFLPGRSGATLMSRLRERFPQSVLIGVSALSDAAMARKCKGLGADLFIGKPLDPQRLAEALQSRHTSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAS9</accession>
    <name>Q1DAS9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">MXAN_2015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552099.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DAS9"/>
    <dbReference type="STRING" id="246197.MXAN_2015"/>
    <dbReference type="EnsemblBacteria" id="ABF90817">
        <property type="protein sequence ID" value="ABF90817"/>
        <property type="gene ID" value="MXAN_2015"/>
    </dbReference>
    <dbReference type="GeneID" id="41359425"/>
    <dbReference type="KEGG" id="mxa:MXAN_2015"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_7"/>
    <dbReference type="OMA" id="IESKVAM"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="47156" checksum="2B49D41F659F5F8C" modified="2006-07-11" version="1">MAGKNVEKRDNQTLCCSFCGKSQKEVKKLIAGPTVYICDECIGLCNDIIAEEIDREETKDTKLRIPRPSEIKAVLDEYVIGQERAKKTLSVAVHNHYKRIESKVAMEDVELQKSNILLLGPTGSGKTLLAQTLARILNVPFTIADATCLTEAGYVGEDVENIIVNLLQAADHDIERAQRGIVYIDEIDKIARKSENPSITRDVSGEGVQQALLKLIEGTVANVPPKGGRKHPQQEFLQVDTTNILFICGGAFGGLDQVIERRMGGRSLGFGADVQSKKQRSLTELLKHVEPEDLLKFGMIPEFIGRLPIITALEELDEAALINILNQPKNALTKQYRKLFELDGVTLKFTDGALKAIANEAIRRKAGARGLRSILESAMLDVMYEIPSRKTAREVLISEEVILKKSEPVVLHAQPEKEAAEPKKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAU3</accession>
    <name>Q1DAU3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Twitching mobility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pilT</name>
        <name evidence="4" type="ORF">MXAN_1995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1995"/>
    <dbReference type="EnsemblBacteria" id="ABF92951">
        <property type="protein sequence ID" value="ABF92951"/>
        <property type="gene ID" value="MXAN_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1995"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="WELDCSY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="491" mass="52959" checksum="3D427E316A90CD39" modified="2006-07-11" version="1">MCFRGPSRPIACARERLVGFAPLMELNEILQIALRGGASDIHLKAGLPPMFRVDGSLVPLKDGRRLPPEEVARMAFGIMNEFQKEKFKGSNEVDLAYGVPGLGRFRVNVFQQRGTVGAVLRVIPFKVMTIQDLLLPQILAKICGEERGLVLVTGTTGSGKSTTLAAMIDYINANETSHIMTIEDPIEFLIRDKRSIVNQREVGVDTMTFAQALKSALRQDPDVILVGEMRDHETIETALHAAETGHLVMSTLHTLDATETINRIVSAFPPHQQKQVRLQLASVLKAVVSQRLVPRADGKGRVAAVEVLRVTARVREMIEDKDRTKEIHDAIAQGTDTYGMQTFDQSLMSLVRQGLVTYEEAHRQATNPDDFALRFSGISGTSDSKWDNFDSKPGESRPIPGSSAFAQKGAPTAVAAPQAAPAPAPMAQPMRPAAPAAQQMRPGGPPQAMRPGAPAGAPVGRPMASPAARPPAPAPAPAAAGGDDDFQIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ2</accession>
    <name>Q1DAZ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552036.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1943"/>
    <dbReference type="EnsemblBacteria" id="ABF89734">
        <property type="protein sequence ID" value="ABF89734"/>
        <property type="gene ID" value="MXAN_1943"/>
    </dbReference>
    <dbReference type="GeneID" id="41359356"/>
    <dbReference type="KEGG" id="mxa:MXAN_1943"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026719_2_1_7"/>
    <dbReference type="OMA" id="DGPSWLI"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="48463" checksum="A1F6F3DAA67ADB85" modified="2006-07-11" version="1">MEPIVILGAGLAGLSTAHFLNKPWRLIEKSDRVGGLIKTEVIQGCYFDPTGHWLHLRDPEIQALVNTLWLPEQMVRIQRKAGIFTRGVFTRFPYQVNTHGLPPEVVAENLTGYVEAVYGEKGRELREREPRNFEEFILRYMGEGFAKNFMVPYNQKLWTVHPREMSAAWVGRFVPRPNLKEVVDGALGAGSDAVGYNASFLYPREGGIESLARAMLSHLKGGQLSTHTEPTAIDWKARKVTLSDGSVQPYAGLVSSISLPGLVKLLAKGEAGVPDAVQDAAKQLRATTVTYVAVGAKGANRQPWHWIYLPEPEFHTYRIGSPSAVYAPLAPPDTSTFYVEYSHHGELSLAAAEKYAVEDLVRSQMIHAADDVLFAQAREIPHAYVLYDDAYGPAKSEILRFLEHTGIQIAGRYGQWEYSSMEDAILAGRACARILNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB52</accession>
    <name>Q1DB52_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551977.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1875"/>
    <dbReference type="EnsemblBacteria" id="ABF89288">
        <property type="protein sequence ID" value="ABF89288"/>
        <property type="gene ID" value="MXAN_1875"/>
    </dbReference>
    <dbReference type="GeneID" id="41359289"/>
    <dbReference type="KEGG" id="mxa:MXAN_1875"/>
    <dbReference type="eggNOG" id="ENOG5031R18">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007704_0_0_7"/>
    <dbReference type="OMA" id="PRHHAVF"/>
    <dbReference type="OrthoDB" id="1313542at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="31131" checksum="8ABFF1B115F9C273" modified="2006-07-11" version="1">MVGGPSSVSDFFGHLLGLLRVEALASRHQAVFAAARTRRPAFARHATLESVLAALGDAREETYPEREALTRALVAEIQASSSPAWTAALASAYAPMLTRLRRRIIGNAVPKEDLDQLVLATFLSVARAFPLSRWGDWTAARLRQQTAREVFRYLRKERAEQHDTYTQSQLAEWLPDARPATPVESPRRPSVRRSFVRRDAVLVHLARATLPRSDVEVLMATVVRREKLRAYVSRLVEGDTTEVERVYQRLKRQRTRLMQRLRTQDVDAAVQPPGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB87</accession>
    <name>Q1DB87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1840"/>
    <dbReference type="EnsemblBacteria" id="ABF88794">
        <property type="protein sequence ID" value="ABF88794"/>
        <property type="gene ID" value="MXAN_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1840"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_541743_0_0_7"/>
    <dbReference type="OMA" id="VEHSKTH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="277"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="536" mass="57556" checksum="5EBBD9BCE3EC888A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBU2</accession>
    <name>Q1DBU2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1629"/>
    <dbReference type="EnsemblBacteria" id="ABF89867">
        <property type="protein sequence ID" value="ABF89867"/>
        <property type="gene ID" value="MXAN_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1629"/>
    <dbReference type="HOGENOM" id="CLU_214705_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="45" mass="4751" checksum="0F8862B11AB514B7" modified="2006-07-11" version="1">MAESLRGLGNDMNDGVRTLVSGKKALDVGTANPMNLHPDGGWELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ3</accession>
    <name>Q1DBZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551689.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1578"/>
    <dbReference type="EnsemblBacteria" id="ABF92676">
        <property type="protein sequence ID" value="ABF92676"/>
        <property type="gene ID" value="MXAN_1578"/>
    </dbReference>
    <dbReference type="GeneID" id="41359023"/>
    <dbReference type="KEGG" id="mxa:MXAN_1578"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056905_0_0_7"/>
    <dbReference type="OMA" id="TWRLIVH"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42334" checksum="279135360DA88A77" modified="2006-07-11" version="1">MSSTIAPVPSPSQSSDLRLVPVEIAPETFWVGKREPGNIFYANPYLLRFRGTDKKTQRPTEFNLLIDPGSSSDFSTIHTKVTSLIGGMERLSAMFINHQDPDVGSSASIISARYAPRAGLLCSEDTWRLIVHQNLPRHRFIPTEKFAQGLSVPTGHRLLPVPSPFCHFRGAVMLYDPQTRVLFTGDLFGGLTDSNAKGIWADESDWAGIRAFHQIYMPVNSALQRTVAAIRKLEPGVEMIAPQHGRIIRGPLVQQFLDRMEKLQVGLDIMDEAQDRTHLQAWNAVLDRVVSLARGYLGDSVEAKLAASPELSDTAQYDGTRLVVSRLGKWTLEHVVDLLCHGEPPEIAGPIIVEATSAAAEYNLPTPHLDIEGVGAPSHVSLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCA0</accession>
    <name>Q1DCA0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, 2OG-Fe(II) oxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551582.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1466"/>
    <dbReference type="EnsemblBacteria" id="ABF91825">
        <property type="protein sequence ID" value="ABF91825"/>
        <property type="gene ID" value="MXAN_1466"/>
    </dbReference>
    <dbReference type="GeneID" id="41358912"/>
    <dbReference type="KEGG" id="mxa:MXAN_1466"/>
    <dbReference type="eggNOG" id="COG3491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_7"/>
    <dbReference type="OMA" id="FKEAMNF"/>
    <dbReference type="OrthoDB" id="400496at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="35725" checksum="1D027B659268909D" modified="2006-07-11" version="1">MSPTQRRIPVVNLSHYRTGTPQERARFVQVFGDGIKEFGFVTVEGHGIDDGLIRRTYTDVERFFALPEATKAQYAQAGHGGQRGYIGYGQEHAKNRQVGDLKEFWHVGRELPPDHKYHALYGPNVWPTEVSTFREHTLSLFNALDGAAGVMLQALAEYFGVARDTFSGMATDGNSVLRLIHYPPLKERFIPGGVRAAEHEDINLITLLCEGTASGLELLTRDGEWLPVDTLRGQIVVDSGDMLSRVTNEIIPATTHRVVNPRSKEEDTVRYSMPFFVHPYADCVLQALPCTQTADTPARHAPITADAFLKQRLRENGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ4</accession>
    <name>Q1DCJ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1372"/>
    <dbReference type="EnsemblBacteria" id="ABF89471">
        <property type="protein sequence ID" value="ABF89471"/>
        <property type="gene ID" value="MXAN_1372"/>
    </dbReference>
    <dbReference type="GeneID" id="41358818"/>
    <dbReference type="KEGG" id="mxa:MXAN_1372"/>
    <dbReference type="HOGENOM" id="CLU_1184020_0_0_7"/>
    <dbReference type="OMA" id="QSAFRIN"/>
    <dbReference type="OrthoDB" id="1375218at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="27556" checksum="9FB8DFAFD2CD1A16" modified="2006-07-11" version="1">MPGCHGGRMLARTRRFKNMTPSLRRSLFRGLFLVGSALALSCGSDGPFFRIAFDLPDTLTAIPGESLPVDITVRREGDDQSAFRINLQNAPEGVTLTPEIVLPEGEPSVTATATYSVAQDTQARGMMRAQLMATNATETFAASANIFLVILPPPVAQPDFSVTIEPRQLDLFAGQNEKVRITVTRAEGFTGPVTVALESPTRRISMPTVTIPADQTFVEPYIDTDRGMTRVPVAASITATSEDGRQASTGTTINVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCN2</accession>
    <name>Q1DCN2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thrombospondin type 3 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DK1622</strain>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88907.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="497" mass="53141" checksum="A06037678A7B031D" modified="2006-07-11" version="1">MDVGSTPRPHWGVPPTPFVRRVPARAQLTDIPGLPPSVWYGSFLARRPALKGVTMTRARFASALTLGAFLVLGPTGALAQSNNNPDNPECLGDRCGMPLEVGGGCGCGAGGSVWVNYTDDGDTLSYTDDADGDGRADDRDNCPFVSNRDQADDDGDDVGNACDNCATLSNFQQRDADGDGIGDDCDPDQDNDGRDNAEDNCPLVPNPGQEDLDGDGLGDVCDLDDDGDGVLDGDDNCPRVYNPDQVIKDEEAHLCRVDADNDNISDSSDNCPGVPNPDQRDTDGDGVGDACDPDIDGDSVLNTQDNCPAVENRDQRDDDRDGIGDACDTRYCLVTNPERPDDCLDPKSPFTVSAGGLFRTDKAGITIRPPLFANRNGAAMEYEWVVVKRPSGSISVVERPQGAVTLSRDWQYMYVDGSVPTFVPDKKGEYQLQLTARLAFSDRVFPDQRVSTSTLTVLVGDESEKGNNCSSVPAGFSATALGAALLSVLMRRRRPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCN6</accession>
    <name>Q1DCN6_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
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        <name evidence="3" type="ORF">MXAN_1330</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1330"/>
    <dbReference type="EnsemblBacteria" id="ABF88358">
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    </dbReference>
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    <dbReference type="eggNOG" id="COG1716">
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    <dbReference type="HOGENOM" id="CLU_337628_0_0_7"/>
    <dbReference type="OMA" id="QVHAGGH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
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        <property type="entry name" value="YscD_cytoplasmic_dom"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49879"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="512"/>
        </location>
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            <end position="528"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="749" mass="77504" checksum="D95EA32D45CB9778" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH2</accession>
    <name>Q1DDH2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1040"/>
    <dbReference type="EnsemblBacteria" id="ABF90275">
        <property type="protein sequence ID" value="ABF90275"/>
        <property type="gene ID" value="MXAN_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="41358494"/>
    <dbReference type="KEGG" id="mxa:MXAN_1040"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014385_3_2_7"/>
    <dbReference type="OMA" id="LIQYDIT"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="302"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="675" mass="75423" checksum="DC99F05B80D9ECF1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM9</accession>
    <name>Q1DDM9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF92621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0983"/>
    <dbReference type="TCDB" id="2.A.6.1.7">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92621">
        <property type="protein sequence ID" value="ABF92621"/>
        <property type="gene ID" value="MXAN_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0983"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="VYAEFDW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1040" mass="111175" checksum="A4024447A472E16F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDR9</accession>
    <name>Q1DDR9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0943"/>
    <dbReference type="EnsemblBacteria" id="ABF90449">
        <property type="protein sequence ID" value="ABF90449"/>
        <property type="gene ID" value="MXAN_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0943"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_3_7"/>
    <dbReference type="OMA" id="TEHAETY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="20415" checksum="C084D85A578E829F" modified="2006-07-11" version="1">MPTRPPTSPTPAAMPRYERLRRLALRFPELDASAIETCITLLRASHDLSGAYEAHLGRHGLSMGRFMVLVRLFTTEDDDVERVRGLTPADLAESSGVSRATMTGLLDTLEKDALISREDHPEDRRMYTVRLTPKARQLIESVLPDHYRRIAALMAPLSEEERTTLRTLLAKVTSGLPLLKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT5</accession>
    <name>Q1DDT5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine dioxygenase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551048.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0927"/>
    <dbReference type="EnsemblBacteria" id="ABF90497">
        <property type="protein sequence ID" value="ABF90497"/>
        <property type="gene ID" value="MXAN_0927"/>
    </dbReference>
    <dbReference type="GeneID" id="41358386"/>
    <dbReference type="KEGG" id="mxa:MXAN_0927"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480527_0_0_7"/>
    <dbReference type="OMA" id="TRFAWAG"/>
    <dbReference type="OrthoDB" id="1571420at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="21737" checksum="AB132EC74D7AE109" modified="2006-07-11" version="1">MREPIIDQREHGAVAQALLGWPLPEQTEDIVSMAWLVERLRSSRVDWGLLDKLVRFEPSGYTRQTIARTTACELLLVSWLPGQASRVHDHGGSGGASWLVRGMLRETRFAWAGDRLVPEVIVGANEGDLLVEFPDTIHRIDNASRHGAVSLHLYAPPMQGMTPYDASLAPESLRPPRPLAAKREAPGRRRRPRAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDU6</accession>
    <name>KMO_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="1">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kmo</name>
        <name type="ordered locus">MXAN_0916</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551037.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDU6"/>
    <dbReference type="SMR" id="Q1DDU6"/>
    <dbReference type="STRING" id="246197.MXAN_0916"/>
    <dbReference type="EnsemblBacteria" id="ABF90126">
        <property type="protein sequence ID" value="ABF90126"/>
        <property type="gene ID" value="MXAN_0916"/>
    </dbReference>
    <dbReference type="GeneID" id="41358375"/>
    <dbReference type="KEGG" id="mxa:MXAN_0916"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023210_0_1_7"/>
    <dbReference type="OMA" id="REFMFIA"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000361941" description="Kynurenine 3-monooxygenase">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01971"/>
        </source>
    </evidence>
    <sequence length="464" mass="50920" checksum="F89635B2099C96B9" modified="2006-07-11" version="1">MSEARKDTVTVVGAGLVGSLLSIYLARRGHTVELLERRPDMRRETVDGGRSINLAISTRGLHALRQVGLENEALKHAIPMRGRMIHPPQGELVYQPYGKDDSQHINAMSRGWLNAFLMTAAEATGKVRIRFKQRVTDVDFGSGALTVHDDATGEARQEPGRVVFGTDGSASAIRQALEKRPDFKGTQEQLGHGYKELTIPAGPGGAFQMEKHALHIWPRGTFMLIALPDEEGSFTCTLFLPWQGPVSFASLDTPAKLEAFFGAQFPDAKALIPDLVEAFFSRPTGSMVTVKGAPWHAGGQTLLLGDAAHAIVPFFGQGMNCGFEDCVVLDQLLGQGAGWEQVFTDFERLRKTNADAIADMAVENFVEMRDSTGDPRFLFRKAVEKVLLNAFPGEFVSRYSLVSFSHVPYRLAYQMGALTDGIVSELSEGLPRAEDVDLKRAAELIRSRLTPFMKEHADGFRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEC6</accession>
    <name>Q1DEC6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550857.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0731"/>
    <dbReference type="EnsemblBacteria" id="ABF90206">
        <property type="protein sequence ID" value="ABF90206"/>
        <property type="gene ID" value="MXAN_0731"/>
    </dbReference>
    <dbReference type="GeneID" id="41358202"/>
    <dbReference type="KEGG" id="mxa:MXAN_0731"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089297_0_0_7"/>
    <dbReference type="OMA" id="DFQAMQP"/>
    <dbReference type="OrthoDB" id="1660023at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="31413" checksum="DB44FB762B2A5A02" modified="2006-07-11" version="1">MSASIDYSHAEKLRLELAEPLFNPLLKKWVGKGELDYEVYLKTPTLLSLQAPDGERVAHDELMFQVVHQAQELWLKLASREAVEVVAELDRDALWAASSRLERICRVLQAVKQELAILETMTPDTYQVIRRSLGNGSGQESPGYNMLRRVALGLEGALDRLLARRGLALASVYTSGGPDDLKRICEQLVDMDEAFQGWLHAHFQLVRRTIGVDRTVKALDGLPTQVLAGRMMLPLFRQLWDVRLELTSGWQREGGIAPGANRAPPGGGCPMAHAARMQVEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP3</accession>
    <name>Q1DEP3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0612</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550743.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0612"/>
    <dbReference type="EnsemblBacteria" id="ABF87597">
        <property type="protein sequence ID" value="ABF87597"/>
        <property type="gene ID" value="MXAN_0612"/>
    </dbReference>
    <dbReference type="GeneID" id="41358090"/>
    <dbReference type="KEGG" id="mxa:MXAN_0612"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012704_0_0_7"/>
    <dbReference type="OMA" id="GLSICDT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PHYTOCHROME_2" evidence="5">
        <location>
            <begin position="187"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="353"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="491"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="723" mass="78275" checksum="346D13D1D2826C1F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DER5</accession>
    <name>Q1DER5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF89046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0590"/>
    <dbReference type="EnsemblBacteria" id="ABF89046">
        <property type="protein sequence ID" value="ABF89046"/>
        <property type="gene ID" value="MXAN_0590"/>
    </dbReference>
    <dbReference type="GeneID" id="41358069"/>
    <dbReference type="KEGG" id="mxa:MXAN_0590"/>
    <dbReference type="HOGENOM" id="CLU_462960_0_0_7"/>
    <dbReference type="OMA" id="KGNDYAT"/>
    <dbReference type="OrthoDB" id="417413at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188458" evidence="1">
        <location>
            <begin position="25"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="590" mass="63526" checksum="E1EF5232821EE68C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DET0</accession>
    <name>Q1DET0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0575"/>
    <dbReference type="EnsemblBacteria" id="ABF88276">
        <property type="protein sequence ID" value="ABF88276"/>
        <property type="gene ID" value="MXAN_0575"/>
    </dbReference>
    <dbReference type="GeneID" id="41358057"/>
    <dbReference type="KEGG" id="mxa:MXAN_0575"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_7"/>
    <dbReference type="OMA" id="IDGMERM"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14941" checksum="EC337FD7C1D91E4A" modified="2006-07-11" version="1">MNKVIFACVRNAGRSLMAEAFFNVMVDPQKARAVSAGTQPGDKVHPEVLAAMRDIGIDLHDVKPRLLTDDLTQDAQWLITLGCGEACPQVPGLQREDWPLEDPKDKSDVLVHRIRDELAARVAGLLEREGWMRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEX1</accession>
    <name>Q1DEX1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550665.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0533"/>
    <dbReference type="EnsemblBacteria" id="ABF87649">
        <property type="protein sequence ID" value="ABF87649"/>
        <property type="gene ID" value="MXAN_0533"/>
    </dbReference>
    <dbReference type="GeneID" id="41358016"/>
    <dbReference type="KEGG" id="mxa:MXAN_0533"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061176_0_1_7"/>
    <dbReference type="OMA" id="FNRGTNK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="391" mass="41935" checksum="6539ECAA67C35B1F" modified="2006-07-11" version="1">MTLSRRSVIQGAAAVGSLWAMGCATTGTSGTTASSTQGQGEQSSAPAAPLRILILGGTAFLGPALVEFARSRGHTVTLFNRGKTKPGLFPDVEKLTGDRDPNKGEGLKALEGRKWDAVVDTSGYVPRVVRASAELLAPHVQHYTFVSSISVYKDLSRQGLDETATVATVEDATTEDVEEHYGALKALCEQAAEAAMPGRVFNVRPGLIVGPDDPSDRFTYWPLRVARGGEVLAPGDGVDPLQFIDARDLAAFIIRSVEARTTGIFNATGPSQDLLMRDFLEANKTTLGSDARFTWVDTDFLTKHKVEAWSDMPAWMPRNGKEGGIGKVSIAKALAAGITFRPASETIRDTVAWFKTLPPERQAKPRSGLSAEREKEVLAAWHQERGTANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEY0</accession>
    <name>Q1DEY0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0524"/>
    <dbReference type="EnsemblBacteria" id="ABF89672">
        <property type="protein sequence ID" value="ABF89672"/>
        <property type="gene ID" value="MXAN_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0524"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="KPCLPQD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="18620" checksum="6621DC3AA7F7E673" modified="2006-07-11" version="1">MYRLFNARSNPRGVCPMKSTAMTVPAEDMPTAKEPAPGGNKKRVLVVDDFDDAREMYAEYLEFVGFEVDTARNGVEAVEKASEGEPDIILMDLSLPVMDGWEATRRIKQDSRTRDIPVMALTGHVLAGNAEHARDAGADEFVAKPCLPQDLENKIRNMLKPSKGKVRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFI7</accession>
    <name>Q1DFI7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550450.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0306"/>
    <dbReference type="EnsemblBacteria" id="ABF92223">
        <property type="protein sequence ID" value="ABF92223"/>
        <property type="gene ID" value="MXAN_0306"/>
    </dbReference>
    <dbReference type="GeneID" id="41357805"/>
    <dbReference type="KEGG" id="mxa:MXAN_0306"/>
    <dbReference type="HOGENOM" id="CLU_1445390_0_0_7"/>
    <dbReference type="OMA" id="VSPYPHD"/>
    <dbReference type="OrthoDB" id="1591793at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="21836" checksum="4A6AE3B9CF2034EB" modified="2006-07-11" version="1">MSPMAFDIREIQTQLEAAPIVSPYSHDLALAIICDTFRLAKVRPPSRADWGALEDQARSPLWREQVVMLAHVLVSSALRQETVQALNKNDDATTLLQRFFQDVAPLTAEMIRSNTFRREEFIRKWVRVVGGECKGESPKGSVARIEQLDYRKAEAEMRRAEEARKKEADKRQQALREAEQRATEARGWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM3</accession>
    <name>Q1DFM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550414.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0269"/>
    <dbReference type="EnsemblBacteria" id="ABF92393">
        <property type="protein sequence ID" value="ABF92393"/>
        <property type="gene ID" value="MXAN_0269"/>
    </dbReference>
    <dbReference type="GeneID" id="41357769"/>
    <dbReference type="KEGG" id="mxa:MXAN_0269"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_7"/>
    <dbReference type="OMA" id="YIRVPYG"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="42329" checksum="D1EA463C088FBF81" modified="2006-07-11" version="1">MRALCWNGINDLGVETVGDPRIVNPHDVILQVRMSTTCGSDLHFIDGYIPTMRKGDVIGHEFMGTVVEKGPAVKKVQVGDRVVVPSFIGCGSCWYCQHDLWSLCDNTNPKGELQEPLFGYQTAGIYGYTHTFGGYAGAHAQFVRVPHADNDCFRVPEGVTDEQALFLSDAVPTGYMGADFCDIQPGQTVAVWGCGGVGLMAQKAAFLLGAERVIGIDRFPERLKLAREKVGAETISYEEVDSVLDVLKELTGGRGPDACIDAVGMEAHGTGVGAAYDRAKQAMRLQTDRGQALRQAILACRKGGILSVVGVYGFMDAFPLGAIMNKGLTVRSAQQHGQKYLPRLLEHVVKGELDPSFLATHRFSLEDAPKGYELFKKKQDGCVRAVFLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG18</accession>
    <name>Q1DG18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0122"/>
    <dbReference type="EnsemblBacteria" id="ABF92890">
        <property type="protein sequence ID" value="ABF92890"/>
        <property type="gene ID" value="MXAN_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0122"/>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029639_1_0_7"/>
    <dbReference type="OMA" id="AHRNVIG"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_CH_N" evidence="8">
        <location>
            <begin position="45"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="GTP_cyclohydro2" evidence="7">
        <location>
            <begin position="272"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="454" mass="49534" checksum="B47A59C81E8BB0AD" modified="2006-07-11" version="1">MVGPDRRLVDELKRAPRREAPPPAPRLCSRARKEGAPMAEKKNLNHIRLTSHPDGDVPSVPIRWGDGEPTRRGPVVATLTEAGHRNVIGTHAGAYAVYRALAVAAGMLPQDHRADLKNTAPAAQVGPHPSWSDPQRIVSLDPWGAIAPQAFRPFAEQGIDFRPTIAVTKAHINFPEVRDAIDAGRLTPDGDLLRGNGDIKVTKAAVDPVWYLPGIAKRFGMTESALRRGLFEQTGGMFPELITRPDLHVFLPPIGGLTLYVFGGIETLADRDVPLTVRVHDECNGSDVFGSDICTCRPYLAHGIEECVRTAQAGGAGLIVYLRKEGRALGEVTKFLVYNARKRQEGGDSAATYFQRTECVAGVQDMRFQELMPDVLHWLGITRIHRFVSMSDMKHDAITRSGIEILERVPIPDELIPADAKVEMEAKKAAGYFTQGPVADAAGLAQVKGRDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVM3</accession>
    <name>Q1CVM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557353.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7445"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87622">
        <property type="protein sequence ID" value="ABF87622"/>
        <property type="gene ID" value="MXAN_7445"/>
    </dbReference>
    <dbReference type="GeneID" id="41364594"/>
    <dbReference type="KEGG" id="mxa:MXAN_7445"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_2_7"/>
    <dbReference type="OMA" id="PGQTHIF"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="412" mass="44506" checksum="39E4464DC19C86FB" modified="2006-07-11" version="1">MPSSVQKIGYLIPEFPGQTHIFFWRELQALQGKGVTPELVSTRPPPARIISHSWAREAMSRTEYLTPPGPLGVAKAAAEVARAMPTGWARCLASIARAEGLDAKGRAQLLAFAVMGGRLASLARERGWTHVHVHSCANAAHVALFANLLSGLPYSLTLHGPLYDYGPNQREKWRHARFAFVITKKLLKEVNDELAGALPSRIELAPMGVELRKFNRSVPYSAWTGEGPLRIFSCGRLNPCKGHADLIDAVGMLRAKGLDARLSIAGEDEAGGTTYRKVLEAKIQETGLGDAVTLLGAVSEDTVRGEIERAHIFSLASLQEPLGVAIMEAMAMRVPVVVTGAGGVPELVDDGVDGILVPPQQPRTLADKLETVARDAQEAHRLGEAGRRKVETTFSSERSADMLAQMLQRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS5</accession>
    <name>Q1CVS5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557303.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88995">
        <property type="protein sequence ID" value="ABF88995"/>
        <property type="gene ID" value="MXAN_7391"/>
    </dbReference>
    <dbReference type="GeneID" id="41364550"/>
    <dbReference type="KEGG" id="mxa:MXAN_7391"/>
    <dbReference type="HOGENOM" id="CLU_132065_0_0_7"/>
    <dbReference type="OMA" id="CARDYLW"/>
    <dbReference type="OrthoDB" id="2038152at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="18391" checksum="1BFF42105516D775" modified="2006-07-11" version="1">MEWPEPACGRGRGTASRPCARDYLWRQRRTVTETRRAMAISKRGLVDRVKEVAVQAGTRGARVLLGTAVVTARGVANLQSKIRGTPARGRVKTAAATGTRRTAKAARGVIESGKPTKAPARRKSPSTKTASAAGANNQVGRKSVPGQAAAARRGTAKTPRPATRAKRGQKHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW09</accession>
    <name>Q1CW09_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557220.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7301"/>
    <dbReference type="EnsemblBacteria" id="ABF88539">
        <property type="protein sequence ID" value="ABF88539"/>
        <property type="gene ID" value="MXAN_7301"/>
    </dbReference>
    <dbReference type="GeneID" id="41364463"/>
    <dbReference type="KEGG" id="mxa:MXAN_7301"/>
    <dbReference type="eggNOG" id="ENOG502Z85F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066824_1_0_7"/>
    <dbReference type="OMA" id="NFTNGFR"/>
    <dbReference type="OrthoDB" id="959247at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032315">
        <property type="entry name" value="DUF4846"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16138">
        <property type="entry name" value="DUF4846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="36769" checksum="B00063A2833D4B2E" modified="2006-07-11" version="1">MRELQAREKPPTRGATCRAALTPGDGCFVSAFDCSPCSSSPSWPATEGRFRPWAWTLLWALCLLPASGWAAEEGQPRPATREELTRYAWLPAQAVVRPLEAAVAPPEGYTRVPVVKGSFGAWLRGLPLRPDGTPVLSHQGGRILASEDARLAAVAELDVGTANLQQCADSVIRLHAEWLWASGKRERLAYRFTSGHLAEWPRYAEGDRARVSGSKVSWVRGAAPDASRASFRAWLDLVFTYAGTHSLESLKGRPSREDVRPGDFFVLGGSPGHAVLVLDVAANAAGKRVALLGQGFMPAQDFHVLSAGGDTGPWFPLEGEDVVTPFWKPFPWSSLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW77</accession>
    <name>Q1CW77_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557152.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7233"/>
    <dbReference type="EnsemblBacteria" id="ABF87957">
        <property type="protein sequence ID" value="ABF87957"/>
        <property type="gene ID" value="MXAN_7233"/>
    </dbReference>
    <dbReference type="GeneID" id="41364401"/>
    <dbReference type="KEGG" id="mxa:MXAN_7233"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639081_0_0_7"/>
    <dbReference type="OMA" id="IAWVEKT"/>
    <dbReference type="OrthoDB" id="363392at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="308"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="487" mass="53710" checksum="61589A26AED59FB0" modified="2006-07-11" version="1">MWNCCSIVFIRLGWILVAFRCGHPEVGADSVTRSFPERCSRGWASAGPTWGSQGMCHRAARVDAESPRASVSRLMLKLQWLQVHQFRSVKPGTRLLFSPSLNVLLGENGTGKSTLLDLAAAVVSSDFTPLRHEAFDLEYALAADTGRITVRVRNVPSGAEGTSGLSMDITVAPRDMAWPLVIHREGQQLRVSREDDTTDVVHERIAPEVGGRLWLVLMTGGIAWVEKTGEGTASVEPMLAMAREVSAQADLHRFDEGLAHFDQLWRAELRLSRRTEGVLATGTGVASEDLLDGLRKVAAAQWGASRYVLSSENVPFLRDAARLLGFASAEALLSPLETQPQGKYETLSLGNLDLCFVTAAGQRLSARQLGYGQKRLVAFLHYLAHARAVVIADEVAHAFHPRQVRAILEQLEPRQALLTSQSPELLDSLTFDSPEQVRSTFVRCRREEDTGRLVWENLSPEAAGDFFTAWRAEPRRVGELLQAKGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG6</accession>
    <name>Q1CWG6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557063.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7144"/>
    <dbReference type="EnsemblBacteria" id="ABF91986">
        <property type="protein sequence ID" value="ABF91986"/>
        <property type="gene ID" value="MXAN_7144"/>
    </dbReference>
    <dbReference type="GeneID" id="41364318"/>
    <dbReference type="KEGG" id="mxa:MXAN_7144"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="LPWLTCF"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="225" mass="24724" checksum="1CCB3651734169A9" modified="2006-07-11" version="1">MPSPLISLRNVEKSYPLAGGRAWVLRRIDLDIQPGEFVTLMGPSGAGKSTLLSILGMLDVDWTGEYLLDGQAVHAMKPKARGELSRRTIGFVFQQYHLLDNLTVAENLEVPLSYRDLKRGEREALVGDMLDRFQLVGKKDLFPSQLSGGQQQLVGIARALIANPKVLLADEPTGNLHSQQAKQIMEVFQGLNRDGTTIIQVTHSEANAAYGHRVIQLADGWLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWL1</accession>
    <name>Q1CWL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7099"/>
    <dbReference type="EnsemblBacteria" id="ABF88862">
        <property type="protein sequence ID" value="ABF88862"/>
        <property type="gene ID" value="MXAN_7099"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7099"/>
    <dbReference type="HOGENOM" id="CLU_3138052_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="49" mass="5194" checksum="487B3A2B499FB15B" modified="2006-07-11" version="1">MEGDDAASTHRIAYEARSLADFEAGLVQLASEKKPARSQACGRTSARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWS1</accession>
    <name>Q1CWS1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556958.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7039"/>
    <dbReference type="EnsemblBacteria" id="ABF91095">
        <property type="protein sequence ID" value="ABF91095"/>
        <property type="gene ID" value="MXAN_7039"/>
    </dbReference>
    <dbReference type="GeneID" id="41364214"/>
    <dbReference type="KEGG" id="mxa:MXAN_7039"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_307751_0_0_7"/>
    <dbReference type="OMA" id="QEFTRDY"/>
    <dbReference type="OrthoDB" id="35666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1015" mass="107334" checksum="35ACD7AC255D1653" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWV1</accession>
    <name>Q1CWV1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7009"/>
    <dbReference type="EnsemblBacteria" id="ABF92814">
        <property type="protein sequence ID" value="ABF92814"/>
        <property type="gene ID" value="MXAN_7009"/>
    </dbReference>
    <dbReference type="GeneID" id="41364184"/>
    <dbReference type="KEGG" id="mxa:MXAN_7009"/>
    <dbReference type="eggNOG" id="ENOG5032XCP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427478_0_0_7"/>
    <dbReference type="OMA" id="GGEPQGY"/>
    <dbReference type="OrthoDB" id="177497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="608" mass="66169" checksum="A200EDD127CDE1C9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWZ2</accession>
    <name>Q1CWZ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556887.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6966"/>
    <dbReference type="EnsemblBacteria" id="ABF89342">
        <property type="protein sequence ID" value="ABF89342"/>
        <property type="gene ID" value="MXAN_6966"/>
    </dbReference>
    <dbReference type="GeneID" id="41364144"/>
    <dbReference type="KEGG" id="mxa:MXAN_6966"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="LQISAFP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="294"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="432"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="656" mass="71291" checksum="141C48268B06D4C9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX08</accession>
    <name>Q1CX08_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556871.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6950"/>
    <dbReference type="EnsemblBacteria" id="ABF87794">
        <property type="protein sequence ID" value="ABF87794"/>
        <property type="gene ID" value="MXAN_6950"/>
    </dbReference>
    <dbReference type="GeneID" id="41364128"/>
    <dbReference type="KEGG" id="mxa:MXAN_6950"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="DMSVQMN"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="275"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="58841" checksum="74569E7B81FF735B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX67</accession>
    <name>Q1CX67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556814.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6891"/>
    <dbReference type="EnsemblBacteria" id="ABF85954">
        <property type="protein sequence ID" value="ABF85954"/>
        <property type="gene ID" value="MXAN_6891"/>
    </dbReference>
    <dbReference type="GeneID" id="41364077"/>
    <dbReference type="KEGG" id="mxa:MXAN_6891"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036077_0_0_7"/>
    <dbReference type="OMA" id="CHTCRSM"/>
    <dbReference type="OrthoDB" id="1479209at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187959" evidence="1">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="451" mass="48399" checksum="26C63A45A543E283" modified="2006-07-11" version="1">MRLLAACLLLSGLVACTAANTNAPAAAASHAKGPLPFIEDDYARALAEAQAKGLPLFVDVWAPWCHTCRSMKAYVLSDASLARHADRFVWLEVNTDLTSNAAFQEKYPVEFWPTLYVIDPRQEKALLRFAGSATVAQLEKLFEDGERAYKGGVTGAEALLARGDALYAEGRSAEAAETLVEALAEAPADWSRRGRAVESLLTAMYGAKQHEACAHKALEELPKTPRSLSWANGALLGMYCVLSLPEDHAAGAELRGGLEAKVAEALAPPAIEMSADDRSGLYEVRVQAREVAKDTAAVKALSEEWLAFLEGEAAKAPNPQARTVFDSHRMLAAMKLETPARAIPALEQSEKDLPQDYNPPARLSTLYRLVGRLDDALAASDRALARVQGARRLSVLSGRADILVARQDTASAVKTLEEAITFAKSLPASQVSPRTVAGLEKKLSGLQASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX98</accession>
    <name>Q1CX98_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556783.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6858"/>
    <dbReference type="EnsemblBacteria" id="ABF89898">
        <property type="protein sequence ID" value="ABF89898"/>
        <property type="gene ID" value="MXAN_6858"/>
    </dbReference>
    <dbReference type="GeneID" id="41364047"/>
    <dbReference type="KEGG" id="mxa:MXAN_6858"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059885_0_0_7"/>
    <dbReference type="OMA" id="MEIRVWR"/>
    <dbReference type="OrthoDB" id="831505at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="406" mass="44349" checksum="BD6AB0040CC95A3D" modified="2006-07-11" version="1">MRAPMCRRPSAARRAVVLATAWVLGCGRSPSFGEREPFIPRDSAEVLARVPAVGVDARARERAALRKALAGHAGQLDMALRLARLEVEASRVLGEPRYLGRAQAVLRPWWELATPPLGVRLVRATFHHARRDFPAALEDLDAVVKEDPGNVDAWLLRAEVLGIRGEHAEAAHSCARLTALTSSLTVAVCEARVRSLAGHSRKAHALLSEALRRSERSQESRTRALATLAEAAALAGDAGLAERYFLRAISLDSKDYAARAAYADLLLDAGRAREAAVVVMDHTQDDRLLLRHALAENALRSSRAPEVAHALSRRFEESRLRGDSLLAREEARFALQVEKAPEKALRLAQAVWASQREPWDVRLLIEAALAAGRPEAARPALDFLQASGCEDPGLVFLAERVRSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY30</accession>
    <name>Q1CY30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA/GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556501.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6571"/>
    <dbReference type="EnsemblBacteria" id="ABF90376">
        <property type="protein sequence ID" value="ABF90376"/>
        <property type="gene ID" value="MXAN_6571"/>
    </dbReference>
    <dbReference type="GeneID" id="41363776"/>
    <dbReference type="KEGG" id="mxa:MXAN_6571"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485570_0_0_7"/>
    <dbReference type="OMA" id="VLCIPIG"/>
    <dbReference type="OrthoDB" id="224546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="373"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="561" mass="60009" checksum="7E5F7FAE98DE7D11" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY51</accession>
    <name>Q1CY51_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556480.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6550"/>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87893">
        <property type="protein sequence ID" value="ABF87893"/>
        <property type="gene ID" value="MXAN_6550"/>
    </dbReference>
    <dbReference type="GeneID" id="41363755"/>
    <dbReference type="KEGG" id="mxa:MXAN_6550"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_0_3_7"/>
    <dbReference type="OMA" id="SWPAIWM"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="284" mass="31998" checksum="F8119791D420DB18" modified="2006-07-11" version="1">MTLPRLLPMAVALTGLACDPAANRVNRPGTPPPHTNPQPSTDWELVWQDEFDGPEGTPPSPERWVHDVGGHGWGNEQQEFNTDRTENTAHDGAGNLVITARRERYNGRDYTSGRIRTQGRYETTYGRIEARIQLPVGRGIWPAFWMLGANIHSVDWPECGEIDIMEYRGQLPSILRGSLHGPRYSAGNNLGQDYVVSGVRLNEDFHVYAVEWEPNRIRWFLDGTAFFEATPAQLPEGARWVFDQPQFIILNVAVGGNFVGPVGRDTVFPQQMKVDYVRVYARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY54</accession>
    <name>Q1CY54_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556477.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6547"/>
    <dbReference type="EnsemblBacteria" id="ABF93121">
        <property type="protein sequence ID" value="ABF93121"/>
        <property type="gene ID" value="MXAN_6547"/>
    </dbReference>
    <dbReference type="GeneID" id="41363752"/>
    <dbReference type="KEGG" id="mxa:MXAN_6547"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_0_7"/>
    <dbReference type="OMA" id="PGIENIS"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187982" evidence="1">
        <location>
            <begin position="26"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="2">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="669" mass="72397" checksum="B082228EE1A221E1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY99</accession>
    <name>Q1CY99_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556432.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6501"/>
    <dbReference type="EnsemblBacteria" id="ABF91500">
        <property type="protein sequence ID" value="ABF91500"/>
        <property type="gene ID" value="MXAN_6501"/>
    </dbReference>
    <dbReference type="GeneID" id="41363709"/>
    <dbReference type="KEGG" id="mxa:MXAN_6501"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_7"/>
    <dbReference type="OMA" id="QRPMYEE"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="37567" checksum="2EB0D4849D72362D" modified="2006-07-11" version="1">MALYPVIMAGGSGTRFWPLSRQARPKQFLPLASKLPLITDTSARLKGLASVKDTFIVCGPLHAKAAAKLVKGLPKANLLVEPVARNTAPAIALAAVQVAARDPKGVMVVLPSDHHVADVPGFKRTLADAADLAEAGHIVTLGIKPSRPETGYGYIQVGEALEGGGRKVQAFKEKPDLETARGYMSSGDYLWNGGIFVFRVDVILEAFAKHMPEMKKGLDALRKAAGKRTFGAVLKKVFPKLPSTSIDYGVMEKASNIAVLPGDFGWSDVGSFAAIPEVRPADANGNVVSGNLAVVVDCHSCVVLADKRPLSVVGLTDMVVVDSGDAVLVVPKDKSQDVRKVVEALKARKLTKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYG9</accession>
    <name>Q1CYG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6430"/>
    <dbReference type="EnsemblBacteria" id="ABF86918">
        <property type="protein sequence ID" value="ABF86918"/>
        <property type="gene ID" value="MXAN_6430"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6430"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2845236_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="65" mass="7529" checksum="E1E3F42659B917D3" modified="2006-07-11" version="1">MDSLSLNKLKEGSLVIHDASFVRKLARCWARDLRHSKEITLENGGRTNPWRRLARRATQLVGQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYP6</accession>
    <name>Q1CYP6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6353"/>
    <dbReference type="EnsemblBacteria" id="ABF90104">
        <property type="protein sequence ID" value="ABF90104"/>
        <property type="gene ID" value="MXAN_6353"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6353"/>
    <dbReference type="HOGENOM" id="CLU_3390405_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="32" mass="3309" checksum="DBC3D02D68B72718" modified="2006-07-11" version="1">MGTAGRVTLHGVAAPLSHLATRSRLKALPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ03</accession>
    <name>Q1CZ03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556183.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6241"/>
    <dbReference type="EnsemblBacteria" id="ABF91180">
        <property type="protein sequence ID" value="ABF91180"/>
        <property type="gene ID" value="MXAN_6241"/>
    </dbReference>
    <dbReference type="GeneID" id="41363463"/>
    <dbReference type="KEGG" id="mxa:MXAN_6241"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060070_2_0_7"/>
    <dbReference type="OMA" id="EYVQRMM"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="95"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="32718" checksum="F9CDFD8B2A3FEE11" modified="2006-07-11" version="1">MALASSSRWQPKEPSRARQRHRSVLALARVSRAFEFPRTILHVAKSASGPIIVSEDDEGRRYLQFGWIGAFQSAMWPGFPLRLELDYTRAVVATLAFVPEPSRLLVVGLGGGTIPTFLRAVLPHAHIDAVEIQPQVLDMARRYFDFREDEALHAHLADGRRFIESPGAPYDVIILDAYGTRSIPPALATQEFLRATQARLTPDGVVVGNVLRKSGRPGSLMDPLWQASFPQLYAFDVQASDNRILVGLPHARRLLRARLLARAGQLARKWGVPFNLRARVARRVSGSRGPANSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ66</accession>
    <name>Q1CZ66_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6176"/>
    <dbReference type="TCDB" id="2.A.6.3.7">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88763">
        <property type="protein sequence ID" value="ABF88763"/>
        <property type="gene ID" value="MXAN_6176"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6176"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044987_0_0_7"/>
    <dbReference type="OMA" id="QNWNAAF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="50120" checksum="6C700AB7FB15F91A" modified="2006-07-11" version="1">MLAVALSPAEALAQTLTLRESLDTALHNYGDIRAKQSRRDAAEHDVSYTRKSYLPDVVLSAQQTFGTVNALHGTLYSPGGPSNASTSLPLPEQNWNAAFGALYSVLVHWNVSTFGRLDRQIELSERTHELKQRELELARFQHGVRVTHAYLNLSTAQRITHIQKQSVARFEVVLESVQSHAENGLVPGVDVSFARAELANARSLQLKAYDAELLASKELAVLMGVPFREFQLEPTFHQSTPESGEPAHVAPGHPVLAEHEGKVRRSEQEKKVAAAEGLPTLFAFGMLQGRGSGFRSNYAQDPGAFSSGYLGGVGIDRGNTLVGLGLSWNLASVLRSFSSEAARDARTRALHQEQELVTQELVAQARFAEHKFDLAREVTHHAVLQRDAATEGFRQSKARYDSGLGTIVELTQATFSATRADVDLELAQNGIWQALLLKSAAAGDLNEFLQQVRGVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ2</accession>
    <name>Q1CZQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5986"/>
    <dbReference type="EnsemblBacteria" id="ABF90335">
        <property type="protein sequence ID" value="ABF90335"/>
        <property type="gene ID" value="MXAN_5986"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5986"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523560_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="520" mass="54306" checksum="EE8967D85516745F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ8</accession>
    <name>Q1CZZ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555839.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5888"/>
    <dbReference type="EnsemblBacteria" id="ABF92819">
        <property type="protein sequence ID" value="ABF92819"/>
        <property type="gene ID" value="MXAN_5888"/>
    </dbReference>
    <dbReference type="GeneID" id="41363127"/>
    <dbReference type="KEGG" id="mxa:MXAN_5888"/>
    <dbReference type="eggNOG" id="ENOG5031DAT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150624_0_0_7"/>
    <dbReference type="OMA" id="HADTPWE"/>
    <dbReference type="OrthoDB" id="1825737at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="143" mass="15089" checksum="E7BD438B6D94E3B8" modified="2006-07-11" version="1">MGPGVVAPGAARSELEANGAAPHALPTHGDGTMAGKKDKGPQDARPRDIGDDQQAGFHAGENFQPRNRGQVADAQDRGAADASRHLAHEHGDAAPHADTPWEARVERGEEWTSQDVPDREARGDEEPDSAVSRQGLVSPPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ9</accession>
    <name>Q1CZZ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555838.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5887"/>
    <dbReference type="MEROPS" id="S01.260"/>
    <dbReference type="EnsemblBacteria" id="ABF91961">
        <property type="protein sequence ID" value="ABF91961"/>
        <property type="gene ID" value="MXAN_5887"/>
    </dbReference>
    <dbReference type="GeneID" id="41363126"/>
    <dbReference type="KEGG" id="mxa:MXAN_5887"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089283_0_0_7"/>
    <dbReference type="OMA" id="TACHTSE"/>
    <dbReference type="OrthoDB" id="1695507at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="23036" checksum="C45390DC646AB952" modified="2006-07-11" version="1">MRDAGWRTWLGAGVGALLLTACHTSEEETPPDLDDVAAATVTLEPGHCAGVVVEDGRHILTAAHCLRNEDTRVPLSFLGGRRMDGSAVHVDRGRDIAVLRLDAPAPVRPLDVAQALPAPGEQLVFAGRNDRPDEPQQAVLERLGRCPSLPEVPAALFTTIRGRPGDSGAPLVDARMQVVGLVHGGAACRVAAPTAGLAEVVAQLSRRGPALARQAPPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D002</accession>
    <name>Q1D002_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5884"/>
    <dbReference type="EnsemblBacteria" id="ABF89069">
        <property type="protein sequence ID" value="ABF89069"/>
        <property type="gene ID" value="MXAN_5884"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5884"/>
    <dbReference type="eggNOG" id="ENOG5032KXC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282075_0_0_7"/>
    <dbReference type="OMA" id="FTWEGRV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24438" checksum="7F8DA2B1F2C1AFEE" modified="2006-07-11" version="1">MGGNAPGGPPFMNVLAELGIAVAGLVLALVLLSMNLWRSILFLFPSSVRVEPEAPADQMDLPLELSGRANQLQALGFVPLGSHEEKPRLQRATRSYDWAHPGECVFATLHEGQGGAPRLYLLTPLASGGFVITADYRRPALEVPGVYLAGSLEDAPPDRLLRAHLRRLDGLQPAGDFTWEGRVAAGRSWYQGLGRKEIRKQNLQGLLWTVIALAIVASAFFGPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D036</accession>
    <name>Q1D036_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5850"/>
    <dbReference type="EnsemblBacteria" id="ABF87027">
        <property type="protein sequence ID" value="ABF87027"/>
        <property type="gene ID" value="MXAN_5850"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5850"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_7"/>
    <dbReference type="OMA" id="WGPGDTQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="36109" checksum="3B4C654384971D1B" modified="2006-07-11" version="1">MQAMRAFVTGGSGFVGRHLLTALKVRGTPARALARSAAARASVTEAGGEPFEGDLSDVEKLKAGMEGCDTVFHCAAVVKGWGARSEFYETNVRGTERVLEAARAAGVKRLVHVSTEAVLADGSPLERVDETMPLPERPIGDYPSTKGEAERRVLSVNAPDFVTVVVRPRFIWGAGDTSLLPQFQEAVRTGRFRWFGGGRYLTSTCHVANCVEGMLLAAEKGRGGEAYFLTDGEPVEFRGFITAMLATQGVDAGERTLPYGVAATVASVGDLLWGTFGLGGRPPLTRTEVLLMGREVTVRDDKARRELGYEGRRSREEGLREMKAEHQDTASRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0G7</accession>
    <name>Q1D0G7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C4-type zinc finger domain protein, DksA/TraR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555670.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5718"/>
    <dbReference type="EnsemblBacteria" id="ABF90352">
        <property type="protein sequence ID" value="ABF90352"/>
        <property type="gene ID" value="MXAN_5718"/>
    </dbReference>
    <dbReference type="GeneID" id="41362963"/>
    <dbReference type="KEGG" id="mxa:MXAN_5718"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_4_0_7"/>
    <dbReference type="OMA" id="EQPLNEM"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="130" mass="14465" checksum="A1964CFE3F027D0C" modified="2006-07-11" version="1">MNAKQRDELKALLLALHSELTDKTPSRIEPNRTDDARIGGDEDEQPLNEMMQAIASNRNRNMDGVLARVLKALGKLRDDPDAFGECEECGDEIPLGRLRAMPYAEFCVTCQGNKDGPKGRATRSKLTDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V1</accession>
    <name>Q1D0V1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555537.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5583"/>
    <dbReference type="TCDB" id="3.A.1.144.3">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88120">
        <property type="protein sequence ID" value="ABF88120"/>
        <property type="gene ID" value="MXAN_5583"/>
    </dbReference>
    <dbReference type="GeneID" id="41362830"/>
    <dbReference type="KEGG" id="mxa:MXAN_5583"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091276_0_0_7"/>
    <dbReference type="OMA" id="VPIGVVW"/>
    <dbReference type="OrthoDB" id="1028001at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="28925" checksum="B449C131A494486F" modified="2006-07-11" version="1">MAFRPKRALAVFWKDFLDLRKNVGLLVSMMVLPAVMVLVPIGVVWTYVRTPDHADLRSVALFYDPTLPLGASAARFLIDKTLTDWFGMFLVMPVFVPILIASQSVAGEKERRTLEPLLASPVTAAELVTGKSLAALVPSVAITWTAFVLFCVGVDIVAWPLVKMPLMPNALWTFGVFVIAPLFAFFGNGVAVLISARVSEARMAQQLSALVVLPIVGMVGGQVAGVLKAGFGYYLLQGAVVLVLDALLLWASIRLLDRERLVSRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D129</accession>
    <name>Q1D129_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555459.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5501"/>
    <dbReference type="EnsemblBacteria" id="ABF86452">
        <property type="protein sequence ID" value="ABF86452"/>
        <property type="gene ID" value="MXAN_5501"/>
    </dbReference>
    <dbReference type="GeneID" id="41362755"/>
    <dbReference type="KEGG" id="mxa:MXAN_5501"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093389_0_0_7"/>
    <dbReference type="OMA" id="GHVPYFT"/>
    <dbReference type="OrthoDB" id="1588047at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="26571" checksum="2E3CF350E3684CA3" modified="2006-07-11" version="1">MRREVQWMEWGQGRGPRVLLLPGLGARGSGFQALAHQLLPWARPILVEYPEGEAAACGAGALARQVLRAVGEVDAVVASSFGGMVAAHLAAAGAARGVAFLGAFARTEHLGVRGLAIGMMGPIARWARPGAVAAGLAAWTPVSFSRVPEVVPTTALERSSTWHRALAIRGEAPPPELRRLPVSCVCIQGTRDVLVPPSTVERLAASLPPGTPRHLLRGAGHVPYFTHPEACAGLLRPWLAALDAAAAPEVESSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1A0</accession>
    <name>Q1D1A0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ORF">MXAN_5426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555388.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5426"/>
    <dbReference type="EnsemblBacteria" id="ABF87339">
        <property type="protein sequence ID" value="ABF87339"/>
        <property type="gene ID" value="MXAN_5426"/>
    </dbReference>
    <dbReference type="GeneID" id="41362688"/>
    <dbReference type="KEGG" id="mxa:MXAN_5426"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_7"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="349"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="420"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="497" mass="53263" checksum="624295FCF17C3715" modified="2006-07-11" version="1">MSEPPCHEASMETLPEVPQQLEPLIRQIGPALYELGQGFREDMRVPARIVADSELLQQMVQDRSVPQLVNVTTLPGIQGFAIGMPDMHEGYGFPVGGVAGTALPDGVISPGGIGFDINCGVRLLATGLRHEDVKEVLPKVAHDLARSIPTGFGRHGRLSLAPEQMDRVLTEGVPYLVDVLGLGTPEDVDYLEARGCLDGADTAKVSVRAQERGHDQLGTLGGGNHFLEVQRVERVLDSEAAPALGLFEGQLTVLIHTGSRGLGHQVCTDAVRTMDRALAREGIQLVDRQLACAPLSSAEGQDYFAAMCAAANFAWANRQVLTYRVREVFRRWFGDRSAAWPRIVYDVAHNIAKLEPHGGQRLCVHRKGATRAFGPGHPELPAAYHQVGQPVFIPGSMGTASFVLVGKEAAEAISLSSACHGAGRRLSRAASKRQVVGSELRAALNRQGIAVECPSNAELAEEAPLAYKDVDRVVDVVEAAGIARKVARLVPLAVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I5</accession>
    <name>Q1D1I5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphohistidine phosphatase SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555303.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5338"/>
    <dbReference type="EnsemblBacteria" id="ABF86209">
        <property type="protein sequence ID" value="ABF86209"/>
        <property type="gene ID" value="MXAN_5338"/>
    </dbReference>
    <dbReference type="GeneID" id="41362607"/>
    <dbReference type="KEGG" id="mxa:MXAN_5338"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_3_0_7"/>
    <dbReference type="OMA" id="GMQSFPK"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17732" checksum="802E06E9CEFB59E1" modified="2006-07-11" version="1">MRLFLVRHADADAEIPEGLGDEARALTAKSRTSTAQHFASLTERIGPVGRILTSPLVRTVQTAQILSISARFEGPLKVHRCLLPDMPVGAVEPVLNEYADENLVLVGHQPSMGALAAHLLGMQSFPKPVNPGTVIGLERAEGESSPAFKFLFYAAPGQQVLDIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L4</accession>
    <name>Q1D1L4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555274.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90034">
        <property type="protein sequence ID" value="ABF90034"/>
        <property type="gene ID" value="MXAN_5308"/>
    </dbReference>
    <dbReference type="GeneID" id="51987700"/>
    <dbReference type="KEGG" id="mxa:MXAN_5308"/>
    <dbReference type="HOGENOM" id="CLU_069347_0_0_7"/>
    <dbReference type="OMA" id="GDCRVRF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188121" evidence="1">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="37891" checksum="962B851AD47F0D9A" modified="2006-07-11" version="1">MRILFIILTAAITLCLWPTTAQACVCVAGGGNLHTDLKVARERASAIYRARVVPAPRGPYLGTVDVEVLEVIKGPVVTGEKFNLPQGGGGDCRVRFRGEAEYLIYAEPKDARLIWHCSRSRPMTSLDDAEWVWLTTGKLPSLPAVVQRESVSCEPCDMERIGGSLITPPGKALIPPHEERKALALMKARRPFLTHSSAASTGQRLVMVGRSWEGKSFELIQTPAHAAEARCTQQVHLRWCKQLTVSKPYPDESPRFQCVEPETPELACDEAQSRQSKWEPLETLAADQCHWRTSSYARCTFNGPPVPHPEGVPTSPLLVCRPEAGRHPRYACSVQAASPPSQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1P9</accession>
    <name>Q1D1P9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5272"/>
    <dbReference type="EnsemblBacteria" id="ABF86493">
        <property type="protein sequence ID" value="ABF86493"/>
        <property type="gene ID" value="MXAN_5272"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5272"/>
    <dbReference type="HOGENOM" id="CLU_2718145_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="72" mass="7997" checksum="027E47BA618919F9" modified="2006-07-11" version="1">MSAYYAQPDAGERTMTDCRTRIPRDVCPGFWELLGRPENVAGCQRYFGNAALGSGGNPFVWPDPNWQPLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y8</accession>
    <name>Q1D1Y8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555153.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5182"/>
    <dbReference type="EnsemblBacteria" id="ABF86445">
        <property type="protein sequence ID" value="ABF86445"/>
        <property type="gene ID" value="MXAN_5182"/>
    </dbReference>
    <dbReference type="GeneID" id="41362464"/>
    <dbReference type="KEGG" id="mxa:MXAN_5182"/>
    <dbReference type="HOGENOM" id="CLU_583483_0_0_7"/>
    <dbReference type="OMA" id="VNFWSGR"/>
    <dbReference type="OrthoDB" id="933075at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188035" evidence="1">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="452" mass="46453" checksum="B8D99E1B5D3AD75F" modified="2006-07-11" version="1">MSPARALLLAPVLATLVARAAPAADTTAAIPRLARQVTGAVRAQRGVESPVAVNVTGGSAELRRAVSTMLASQLSSAGLSPVVLEAPTADAAETLARAQGARTLVRLSLNVEGGELRARGDVIGTWVNFWSGRTPTRPPKPAATLVETVPADPTVLALALEGAGTSPTSPPETGPQGIRLLGAALARLEHPLAALAAGDLDGDGRDEVVALTEHDVSVFDAEGRLVARKELDSLPAGSATTREPFGALAFLPGPPRLAAWSTRHAHGELLALDKARATLRAVGTLDTAPLGATERGTFVPGQTAFAPTLKLAEGRALTVPAPFTTASMDAQRMLFVHPDGTAAFYAHAGAAPARWTNLGAGSALGDLDGDGVPELITTSTQLTPAPDVLRVHGTSGGDPGTHEPLWQGALPTGRALYVVTARLDGDTRREVIVGLWKPDGTSELFLLRQGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D221</accession>
    <name>Q1D221_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chemoreceptor McP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mcP1</name>
        <name evidence="7" type="ORF">MXAN_5149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555120.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5149"/>
    <dbReference type="EnsemblBacteria" id="ABF91174">
        <property type="protein sequence ID" value="ABF91174"/>
        <property type="gene ID" value="MXAN_5149"/>
    </dbReference>
    <dbReference type="GeneID" id="41362432"/>
    <dbReference type="KEGG" id="mxa:MXAN_5149"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452514_0_0_7"/>
    <dbReference type="OMA" id="ARQTSHA"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="317"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="595" mass="62888" checksum="0A5DFD8E572E4139" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D261</accession>
    <name>Q1D261_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="9" type="ORF">MXAN_5108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555082.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5108"/>
    <dbReference type="EnsemblBacteria" id="ABF87041">
        <property type="protein sequence ID" value="ABF87041"/>
        <property type="gene ID" value="MXAN_5108"/>
    </dbReference>
    <dbReference type="GeneID" id="41362392"/>
    <dbReference type="KEGG" id="mxa:MXAN_5108"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_0_0_7"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="42774" checksum="432A418F5CB23721" modified="2006-07-11" version="1">MSNKKNVVLAFSGGLDTAFCAVYLREQGYDVTTVTVDTGGFPPEQLERIAALSKQLGAVEHVTVDARETLFQGYLRYLIAGNVLRGQVYPLSVSAERACQAAEVVRVAREKGTQALAHGSTGAGNDQVRFDVAFRSLAPELELLTPIRTLSLSRQQELTYLAERGVHMPPKLGSYSVNEGMWGTSVGGAETLDSWKALPEAAFPGGELSQDLKPRPLTVSFEKGVPVALDGEKLGPVKLVEALNALGRTYGIGRGVHLGDTILGIKGRVGFEAPAAHLLVTAHRELEKLVLSGKQLFWKESMGNLYGSLLHEGHFFDPLVKDLEAFLTSSQERVTGDVRLVLHPRTQVVEGVRSPHSLMDAKVATYGEANVLWNGSEAAGFAKLYGVAQMLSHRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2G5</accession>
    <name>Q1D2G5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Iron-sulfur cluster assembly scaffold protein IscU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iscU</name>
        <name evidence="5" type="ORF">MXAN_5002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002634235.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5002"/>
    <dbReference type="EnsemblBacteria" id="ABF89450">
        <property type="protein sequence ID" value="ABF89450"/>
        <property type="gene ID" value="MXAN_5002"/>
    </dbReference>
    <dbReference type="GeneID" id="41362286"/>
    <dbReference type="KEGG" id="mxa:MXAN_5002"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_7"/>
    <dbReference type="OMA" id="YKNPRNY"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISC_FeS_clus_asmbl_IscU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14334" checksum="B3EE34EB29F37C74" modified="2006-07-11" version="1">MAYSDKVIEHYENPRNVGTLDKEDPNVGTGLVGAPACGDVMRLQLKISEDGLIEDARFKTFGCGSAIASSSLVTEWVKGKTVDQAMTISNKDVARELSLPPVKIHCSVLAEDAIKAAIEDFKKKRAARQAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2H3</accession>
    <name>Q1D2H3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4994"/>
    <dbReference type="EnsemblBacteria" id="ABF86131">
        <property type="protein sequence ID" value="ABF86131"/>
        <property type="gene ID" value="MXAN_4994"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4994"/>
    <dbReference type="HOGENOM" id="CLU_102154_0_0_7"/>
    <dbReference type="OMA" id="YVSEATC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="26047" checksum="FD6F0409D8A89AF1" modified="2006-07-11" version="1">MGGGRATRHPPGRAAARRGTLNACAKSPLACLGSPLVLLGPRTHSSLRSWRRRMPMETAADSREYRVVFFCPASSARLERMEVPVRRLLTRIHAPPAELAPLQEAGAITEAGWQVFLVRSLTERSAAQAMAAYVSEATCALAAELDAEVLGLYVDVSGDTARICRCGPEDGPETFAGRRQAALNRTAEWLEVTPVSLSALFHLDLPDAEYEPDADDRFVEEKLREARTLMERYRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D361</accession>
    <name>Q1D361_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554737.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4750"/>
    <dbReference type="EnsemblBacteria" id="ABF87370">
        <property type="protein sequence ID" value="ABF87370"/>
        <property type="gene ID" value="MXAN_4750"/>
    </dbReference>
    <dbReference type="GeneID" id="41362049"/>
    <dbReference type="KEGG" id="mxa:MXAN_4750"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="RWFGNVV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="27009" checksum="D41C7F8D924C655C" modified="2006-07-11" version="1">MDSVLRVEGLEKAYGEVKAVQGLTFEVAPGEVLGLVGPNGAGKTSTLRCLAGILPPSSGRILVAGYDLSRTPVDAKRALAFLPDEPRFFEYLTVWEHLNFTARLYGVEDWEERGRALLEEMELTGKEKSLPGELSRGMKQKLSIACGFLHSPKLILLDEPLTGLDPIGIRRMKASLRRRAEEGAALVLSSHLLPLVEELCHRLLVIAGGKAMALGSLEDIRARLSGAEGEHASLEELFVRITSSGTQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B6</accession>
    <name>Q1D3B6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ORF">MXAN_4691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554682.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4691"/>
    <dbReference type="EnsemblBacteria" id="ABF91859">
        <property type="protein sequence ID" value="ABF91859"/>
        <property type="gene ID" value="MXAN_4691"/>
    </dbReference>
    <dbReference type="GeneID" id="41361990"/>
    <dbReference type="KEGG" id="mxa:MXAN_4691"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_3_7"/>
    <dbReference type="OMA" id="SAHLQMM"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="590" mass="64444" checksum="D718EF17980565BB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T0</accession>
    <name>Q1D3T0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-ribosomal peptide synthase MxaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554520.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4525"/>
    <dbReference type="EnsemblBacteria" id="ABF90459">
        <property type="protein sequence ID" value="ABF90459"/>
        <property type="gene ID" value="MXAN_4525"/>
    </dbReference>
    <dbReference type="GeneID" id="41361827"/>
    <dbReference type="KEGG" id="mxa:MXAN_4525"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_4_7"/>
    <dbReference type="OMA" id="MFRPGDD"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1515" mass="162928" checksum="00EE9E8DCC622B01" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D456</accession>
    <name>Q1D456_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554395.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4394"/>
    <dbReference type="EnsemblBacteria" id="ABF89424">
        <property type="protein sequence ID" value="ABF89424"/>
        <property type="gene ID" value="MXAN_4394"/>
    </dbReference>
    <dbReference type="GeneID" id="41361704"/>
    <dbReference type="KEGG" id="mxa:MXAN_4394"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_5_1_7"/>
    <dbReference type="OMA" id="HAGMVST"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="PTHR21660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="143" mass="15485" checksum="4831DE415D4B6449" modified="2006-07-11" version="1">MAHQNPDYRQDTEDLFTSAAFVMDLGIQPVDIRPGEVEARLVVQPRHLQQDGVIHAGVQATLADHTAGAAAFSVVRKGQRVLSTSITVHLLQTASGEELRCKARVLRAGRRLIVTESEVHAVSGGTPRLVSKTTVTLAVMEPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U7</accession>
    <name>COAX_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type III pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaX</name>
        <name type="ordered locus">MXAN_4151</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554154.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D4U7"/>
    <dbReference type="SMR" id="Q1D4U7"/>
    <dbReference type="STRING" id="246197.MXAN_4151"/>
    <dbReference type="EnsemblBacteria" id="ABF92916">
        <property type="protein sequence ID" value="ABF92916"/>
        <property type="gene ID" value="MXAN_4151"/>
    </dbReference>
    <dbReference type="GeneID" id="41361470"/>
    <dbReference type="KEGG" id="mxa:MXAN_4151"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_7"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000267568" description="Type III pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <sequence length="256" mass="27982" checksum="1A657C043CCE0603" modified="2006-07-11" version="1">MLLAIDVGNTNTVLGVFEGRRLLDHWRVETSTRRTSDEYGILVRQLFTHRGIDPMKVTAVVVSSVVPPLQSNLEKMSERYFRVRPMFIGPGVKTGMPILYDNPREVGADRIVNAVSAYERHHAGVLVVDFGTATTFDAVSPKGEYLGGCICPGINISMEALFQNASKLPRVEFARPPHVIGRNTVHSMQAGLVYGYVGMVDGICARMQAELGFPVKVVATGGLASLVASESKAIHQVDEFLTLEGLRIIYGRNHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4V0</accession>
    <name>Q1D4V0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transmembrane regulator PrtR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554151.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4148"/>
    <dbReference type="EnsemblBacteria" id="ABF87940">
        <property type="protein sequence ID" value="ABF87940"/>
        <property type="gene ID" value="MXAN_4148"/>
    </dbReference>
    <dbReference type="GeneID" id="41361467"/>
    <dbReference type="KEGG" id="mxa:MXAN_4148"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088256_0_0_7"/>
    <dbReference type="OMA" id="WLRAGAM"/>
    <dbReference type="OrthoDB" id="1494577at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="33944" checksum="E72E1BCDFFDFA1CC" modified="2006-07-11" version="1">MNCQDLERLLYPYLDGEFQPEERVDLETHLSGCADCRRRAEEEKQMQQALRRAARHSVSGMRAPASLRAGIQVGLKQEQRRVQFGVWLRAGAMALVVVTVGGGWAAFHAEQRLSAARTEAVQRHSKSKALPFEIASNTPEQVEEWFKDKVDPRITVPQIPKAKPLGGRISILNGREVAYISYETLPDNEGEPSRRLGVFVLPGDNEVVIPKFQALQAVEVDSAQGFNVVTWRDDEIVYEMVTDMDESDIRRMLAERDSGEKLARKSAPEADEPLYSLPPAPRTPHSWPPISVEPVTYPTYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4V3</accession>
    <name>Q1D4V3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4145"/>
    <dbReference type="EnsemblBacteria" id="ABF91280">
        <property type="protein sequence ID" value="ABF91280"/>
        <property type="gene ID" value="MXAN_4145"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4145"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645348_0_0_7"/>
    <dbReference type="OMA" id="ISFGQGC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
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        <location>
            <begin position="198"/>
            <end position="450"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="49686" checksum="BF327347E50C557F" modified="2006-07-11" version="1">MRCVMKRAPLVLVTSDMTFAPKLLFADPKGRVMEHPYLLATLRSGEELVPPQDKPIPLPSTGRLVHLPGRLPVGLHPETGELELVREMKVGGKTFVPNAVGALLPPGYTRTFLPGEVKGSGPVLPQWAYTAAAWVGEGPVAWAIHTDRRSHWDPERFSTPDMKDLVAKHMARFPDNRVLKQLKTCAMLYRCFTSQNTFYVRDEAAIPASVMCNARCVGCISDQPADGPPASHERMDDGPTGEEMGQIGLFHLEHAPGRTMVSFGQGCEGEPLTRWKQIAEAIRYMRARTQAGSININTNASLTRGLEALFDAGLDAIRVSLNSAVKDLYEAYYKPVKYGWEDVEASIALARERGAYLALNLLLFPGVTDREGEVRALERLVKKYRVDQVQTRSLCIDPLQYLEVARERGAGGEPVGIRTLLQRLKAARPGLIVGNFARGLDERENAAGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D553</accession>
    <name>Q1D553_MYXXD</name>
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        <name evidence="2" type="ORF">MXAN_4041</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4041"/>
    <dbReference type="EnsemblBacteria" id="ABF87756">
        <property type="protein sequence ID" value="ABF87756"/>
        <property type="gene ID" value="MXAN_4041"/>
    </dbReference>
    <dbReference type="GeneID" id="41361372"/>
    <dbReference type="KEGG" id="mxa:MXAN_4041"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429468_0_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GET3_arsA_TRC40"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
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            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF87756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="655" mass="70254" checksum="AA3ADB06B72BCFA0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5N2</accession>
    <name>Q1D5N2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone/plastoquinone oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3861"/>
    <dbReference type="EnsemblBacteria" id="ABF90044">
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        <property type="gene ID" value="MXAN_3861"/>
    </dbReference>
    <dbReference type="GeneID" id="41361194"/>
    <dbReference type="KEGG" id="mxa:MXAN_3861"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_2_7"/>
    <dbReference type="OMA" id="AFPVNFW"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="129"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="53053" checksum="5F1D7EC4B914B939" modified="2006-07-11" version="1">MTPSTLLSLPMILCLGAAAAGLLAPSRAWPRRWLALMTMVSLAVVGAMLLVTVRREGIQSMQVGGWAAPFGITLVADLLSALLVLVTGVMGLTVVSYSAATLPASKEAGAYYPLVLVLVGGVCGAFLTGDLFNLFVWIEVMLGASFVLLALEARQEQLEASIKYMSLSLMGSVVLLCAVGLLYGAAGTLNLADLAVTVPGLGTPNLMTAVSMFFLVAFALKAGAFPLFFWLPASYHTPPAAVTTLFSALLTKVGVYALARVFTLVFTQDSQLTSTLLLVMGGLTMVTGVLGAVAQYDMRRLLSFHIISQIGYLIAALGLLTRSALTALIAFLIHYIFAKSALFLVSGATARVTRTYDLHQMGNLYRTQPLLAALFFIPALSLAGVPPFSGFFAKLAVIQAALRAENWIIAGTAVVVGLLTLFSMMKIWREAFWKAPPEDQPQEPTRPLSLGDGVLGPCMAMTLFMVVLGLGAEPLLELADAAAGQLLDPEEYVRAVLGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D604</accession>
    <name>Q1D604_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553750.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3734"/>
    <dbReference type="EnsemblBacteria" id="ABF90505">
        <property type="protein sequence ID" value="ABF90505"/>
        <property type="gene ID" value="MXAN_3734"/>
    </dbReference>
    <dbReference type="GeneID" id="41361067"/>
    <dbReference type="KEGG" id="mxa:MXAN_3734"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470760_0_0_7"/>
    <dbReference type="OMA" id="LEPDLYY"/>
    <dbReference type="OrthoDB" id="255525at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="436"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="577" mass="60627" checksum="276014CD3506C548" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6J4</accession>
    <name>Q1D6J4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553565.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3535"/>
    <dbReference type="EnsemblBacteria" id="ABF87075">
        <property type="protein sequence ID" value="ABF87075"/>
        <property type="gene ID" value="MXAN_3535"/>
    </dbReference>
    <dbReference type="GeneID" id="41360880"/>
    <dbReference type="KEGG" id="mxa:MXAN_3535"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023735_0_0_7"/>
    <dbReference type="OMA" id="RIRHRWH"/>
    <dbReference type="OrthoDB" id="71760at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="758" mass="83872" checksum="705F1D7AB382EAF6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6K2</accession>
    <name>Q1D6K2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553557.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3527"/>
    <dbReference type="EnsemblBacteria" id="ABF87533">
        <property type="protein sequence ID" value="ABF87533"/>
        <property type="gene ID" value="MXAN_3527"/>
    </dbReference>
    <dbReference type="GeneID" id="41360871"/>
    <dbReference type="KEGG" id="mxa:MXAN_3527"/>
    <dbReference type="eggNOG" id="COG1169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_8_4_7"/>
    <dbReference type="OMA" id="REQNPRC"/>
    <dbReference type="OrthoDB" id="1469584at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="177"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="436" mass="46808" checksum="55886DA52BD4DC79" modified="2006-07-11" version="1">MKTHTPVESQRWVAGMTPLAVVDPLAGADVLGVPTVYWERPLAQDAAAGWGEAAVVEAQDASDIPDVLASLGRVQVRWLGEAPESMPGPWFGGIRFGDSGTVDTAWASHGVTRWTLPEVLVFRTARGACVVAFAQEGRGGEDLVRSRLERVRACFPESYRHARGEPVALELRASRLDFEVRVQRALDAIASGHLQKVVLARPLDAEGPAPFDVVDVLARLREQNPRCATFLFRAPDDTCFLGATPETLCRVDGQVLETEALAGTAAPGQADGLRGHDKNVREHASVVRYLVTALTPLAEQVSSDAEPALLALKNVVHLRTGFRAELRPGVTPAQVVEALHPTPAVGGTPRERALSFLVEHEGLDRGWYAGPVGWVGPGRAHLMVALRSARVKGAKARLFVGVGLVAGSNADSEWRETEMKSLAMLRALGGGDVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6K8</accession>
    <name>Q1D6K8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3521"/>
    <dbReference type="EnsemblBacteria" id="ABF93127">
        <property type="protein sequence ID" value="ABF93127"/>
        <property type="gene ID" value="MXAN_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3521"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_7"/>
    <dbReference type="OMA" id="IKMAVCF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF93127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="34899" checksum="E93D08FD701CCE54" modified="2006-07-11" version="1">MAVVDRTVAKLHPSLIPTLEARSPRAIIQLTGGESAKTFTALEKVLANGLALPRSGTLVAVGGGTIGDVSTVAAHVLKRGVRLVQVPTTLLAAVDSSVGGKGAVDMTVRGRVVKNPAGVFHYADEGWVCPEFFDTLSDAQRREGALEAWKMVVSLDAPLFRRYVRKPPALEKLVKDARALKERICAQDPYEHTGLRRVLNFGHTFGHVLESVSRFKLSHGDGVGLGMLLALDVGRHLGVTPEPVAAEVEAALANGPGVQGRERAAALLRRAPMKDVRALLTADKKAGAKGELRMVLLTAIGATEVRDVDESSWRALWPAWTKGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Q1</accession>
    <name>Q1D6Q1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553508.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3476"/>
    <dbReference type="EnsemblBacteria" id="ABF89293">
        <property type="protein sequence ID" value="ABF89293"/>
        <property type="gene ID" value="MXAN_3476"/>
    </dbReference>
    <dbReference type="GeneID" id="41360823"/>
    <dbReference type="KEGG" id="mxa:MXAN_3476"/>
    <dbReference type="eggNOG" id="ENOG5031KI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2451535_0_0_7"/>
    <dbReference type="OMA" id="PGRQDYQ"/>
    <dbReference type="OrthoDB" id="1953883at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="89" mass="9853" checksum="462A330CD119ABA5" modified="2006-07-11" version="1">MGIKDDLKKQALNVSGKAMEKLMADDRRAMAIANAIGKAQRGKQALDRGQEELMKALNFAPRSEFKALGKQLSGLKRRLRELDEKLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6U5</accession>
    <name>Q1D6U5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553464.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3431"/>
    <dbReference type="TCDB" id="1.B.17.2.4">
        <property type="family name" value="the outer membrane factor (omf) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86730">
        <property type="protein sequence ID" value="ABF86730"/>
        <property type="gene ID" value="MXAN_3431"/>
    </dbReference>
    <dbReference type="GeneID" id="41360778"/>
    <dbReference type="KEGG" id="mxa:MXAN_3431"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043115_0_0_7"/>
    <dbReference type="OMA" id="ADAWQST"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="502" mass="55228" checksum="123E6FE3E80AD274" modified="2006-07-11" version="1">MRLSLLVGAALLAGGCASIQKERGHAEVAALVEERLGRKTRWNQGTPEDAEVARHLDALLKEDLTSDHSVEVALLNNPALQATYEDLGVSQADMVQAGLLSNPTLDGSIGFPISGRGASEHEVSLVQDFVDLFTLPLRKRVAREQFMADTLRVAHEALATAAKVRKAFSEVQALQQLMELRRMALQAAVAAADLSARLRAAGNITELELASEQAAAEGARLELAEGELALVEAREHLNRLMGLWGPRTQWTLSEKLPPLPDQEVSLAHLESLAIRHRLDIDAARKQVMLLWNALELARSTRFFGRVDVGVHEHRDADGPRLFGPTLSLELPIFDQRQALIARLEAQHRQGERRLMELSVNTRSEVRAARARLLALRLVADRYRRVVLPLREKVVEQSQLQYNAMQIGLFQLLSAKREQVDAYQGYIEAVRDYWMARADLEQLVGGRLREGSAAPTPSPSQPSQRVPPGPPGPPAQPAPPGTPSGHGQDVTHGTESPHEHPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X1</accession>
    <name>Q1D6X1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">MXAN_3405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553438.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3405"/>
    <dbReference type="EnsemblBacteria" id="ABF92639">
        <property type="protein sequence ID" value="ABF92639"/>
        <property type="gene ID" value="MXAN_3405"/>
    </dbReference>
    <dbReference type="GeneID" id="41360752"/>
    <dbReference type="KEGG" id="mxa:MXAN_3405"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_0_7"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF92639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="18946" checksum="3A9E921836AD4367" modified="2006-07-11" version="1">MSSGSDNIPMTPSGLRKLKEELKHLQSVERGKISREIEVARAHGDLRENAEYHAAKEKQSHIEGRILTLNDWIARAEVIDPKKLGGDKVIFGATVDLLDTETDKPVSYRLVGEIEADLKKRWIAVTSPVARALIGKKVGDIATVQSPGGVRELEVQEIRFEEPEEEAPASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A9</accession>
    <name>Q1D7A9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553310.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3265"/>
    <dbReference type="EnsemblBacteria" id="ABF85859">
        <property type="protein sequence ID" value="ABF85859"/>
        <property type="gene ID" value="MXAN_3265"/>
    </dbReference>
    <dbReference type="GeneID" id="41360617"/>
    <dbReference type="KEGG" id="mxa:MXAN_3265"/>
    <dbReference type="HOGENOM" id="CLU_945663_0_0_7"/>
    <dbReference type="OMA" id="PCAERED"/>
    <dbReference type="OrthoDB" id="1465674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="217"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="32374" checksum="3CF4B09E2335DA36" modified="2006-07-11" version="1">MPSLPLLLLLASLPCAEREDITLDLRETAEYRPAGFADEASTLSARLGGIPLPPVQDGDTAPERAEQIARFLKEACDVQALANSPSAVPPPPTEPERLEAILDRPEFARARQRHGDALKRIMREVTAWLEGLFESRGAQGFAVATRAVMLGLALALILWSVLRLRARRGRKAAHVSASSAANAEPLVLDSPAEHLRRARAALSTDAREAIREGLLSLLSSLEERRLARPDRVRTNRELAAELPGRGASAALVREVERLMGWYDRTFYSLAPVAPEEAARFVTEVESLNGTLATEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Q5</accession>
    <name>Q1D7Q5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553165.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3115"/>
    <dbReference type="EnsemblBacteria" id="ABF86119">
        <property type="protein sequence ID" value="ABF86119"/>
        <property type="gene ID" value="MXAN_3115"/>
    </dbReference>
    <dbReference type="GeneID" id="41360476"/>
    <dbReference type="KEGG" id="mxa:MXAN_3115"/>
    <dbReference type="eggNOG" id="COG1300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069787_0_0_7"/>
    <dbReference type="OMA" id="AQGRMWT"/>
    <dbReference type="OrthoDB" id="1745181at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="35009" checksum="B0B33F5AFC533F9F" modified="2006-07-11" version="1">MATPLPAYVAQRRADWDALQALLAKQRSGTLKLGELRTLDTLYRRASADLAHAQTFYAGTDVHRFLNQLCGQAYASIYQPPRERWPAVRDFFRREFPATLRRERGFVGASAVLFILGILLGALVVLWEPRGAELLVPSGVRHYVAQGRMWTDDILSVAPPNSVASGIATNNLTVTIVTFALGLTGGLGTLFLLVNNGVHIGAISALCAREGMLGGLLDFIAAHGPVELSILVIAGGAGLMVGQALIDPGELPRGQALAVRGREAVKLVLGCAPFLALIGVVEGYVSPGDMFPTWLKAGLGLVLGALFWAYLLRAGRTEAEATGAPADSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W0</accession>
    <name>Q1D7W0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpB</name>
        <name evidence="3" type="ORF">MXAN_3055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553110.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3055"/>
    <dbReference type="EnsemblBacteria" id="ABF90629">
        <property type="protein sequence ID" value="ABF90629"/>
        <property type="gene ID" value="MXAN_3055"/>
    </dbReference>
    <dbReference type="GeneID" id="41360417"/>
    <dbReference type="KEGG" id="mxa:MXAN_3055"/>
    <dbReference type="eggNOG" id="COG1643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_6_7"/>
    <dbReference type="OMA" id="DLRILVM"/>
    <dbReference type="OrthoDB" id="604268at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="854" mass="93413" checksum="B9925F2D56167BDF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D877</accession>
    <name>Q1D877_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552995.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91447">
        <property type="protein sequence ID" value="ABF91447"/>
        <property type="gene ID" value="MXAN_2936"/>
    </dbReference>
    <dbReference type="GeneID" id="41360301"/>
    <dbReference type="KEGG" id="mxa:MXAN_2936"/>
    <dbReference type="eggNOG" id="ENOG502ZRS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543830_0_0_7"/>
    <dbReference type="OMA" id="FLAVWTD"/>
    <dbReference type="OrthoDB" id="973629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="47075" checksum="3DF289AE76F724C7" modified="2006-07-11" version="1">MFAKGRLHMKREVKAGIAGLLFGSMLVGCGVAPEQEELGGLEDATAESEAEAPMSAETGLEKSGGYAQPAPLARFWPAVAYGGGKFLAVWTDVRTGGIYGTRVKPDGTVLDPADIRINIGDVEGFRPGIGFNGTHFFVVWESVDGIDAVRVKPDGTVVGPVFNVKQSGETVGPARVACSPKICLVTYTVSGDFSNIFFTRVTKDGVVLDTGDESLSASDTFANDASPTWNNKTKEFLVVWSDEHGQGPENADIYGNRVKEDGTILDGDGFPISQAEGAQTTPDVEWTHKNYQVVWTDDRNGNADIFGARVSKTGMVKDPEGIPISTAEGAQAEPRIAHHNDKSLVVWDDRRDGPHAVWGARWGENGDVWDPSGFPISTGDQPQEYLPDVAYGGGKFFVVYSGQETFDPLEPHFILGTRVTHQAHVKDVPALPLTRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D887</accession>
    <name>Q1D887_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_2925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552985.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2925"/>
    <dbReference type="EnsemblBacteria" id="ABF89829">
        <property type="protein sequence ID" value="ABF89829"/>
        <property type="gene ID" value="MXAN_2925"/>
    </dbReference>
    <dbReference type="GeneID" id="41360292"/>
    <dbReference type="KEGG" id="mxa:MXAN_2925"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_0_1_7"/>
    <dbReference type="OMA" id="WACADPG"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="163"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="930" mass="101702" checksum="8FCA3C376AD52502" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8H8</accession>
    <name>Q1D8H8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_2834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2834"/>
    <dbReference type="EnsemblBacteria" id="ABF90950">
        <property type="protein sequence ID" value="ABF90950"/>
        <property type="gene ID" value="MXAN_2834"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2834"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314306_0_0_7"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="24114" checksum="26241E1B50C77EF9" modified="2006-07-11" version="1">MHIFVKAGAQRKRTGQARRRRVGTWSPLAGPCSEELRGDSLDSSCLLPYSAGRRSRLRRRYHGVCSLRAAHQDLTTTTSKWTAMHYLSLTAEFKASHAVTFPDGQREPLHTHDWWVRVWVKARALNHWDVIIDFKDLQDIIVRVCRELHDTNINEHPYFKTVNCTAERVTEYVFKQVESGLPEGVTLDRVHLRRTGGELPEAEYAHARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K6</accession>
    <name>Q1D8K6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase III, delta' subunit</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">holB</name>
        <name evidence="4" type="ORF">MXAN_2800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552867.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2800"/>
    <dbReference type="EnsemblBacteria" id="ABF88614">
        <property type="protein sequence ID" value="ABF88614"/>
        <property type="gene ID" value="MXAN_2800"/>
    </dbReference>
    <dbReference type="GeneID" id="41360176"/>
    <dbReference type="KEGG" id="mxa:MXAN_2800"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_0_7"/>
    <dbReference type="OMA" id="RIESGNH"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="37042" checksum="160B29DC7CF6348F" modified="2006-07-11" version="1">MTLATVLGQPRAVDALQAALRSGAVHHAYLFAGPEGVGKELAAVGLAQALTCPEQPDVGCGACASCQRVERGLHPDVTWVMPDDERVSRGLAGRSDFTGTPSRELRVEQVRQLQERIALRGLESRRKVALIVSAQTMNVQAQNAFLKTLEEPPSDTTIILVASAIDRLLPTIRSRCGKVHFGPLPVDMVAQRVAEARKLDAETAMLAAVMAGGSLGRAMALDVDALSRRKDTLTAFEALRGEDAVGLLRFAEAHGGSREEAESTLELLALWTRDVALVKSGLESGLANRDMVDLARQVAARTSDILLHRRHSLLDAARAAIARNGAPRLQLERMLIDLFTEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8W7</accession>
    <name>Q1D8W7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552757.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2689"/>
    <dbReference type="EnsemblBacteria" id="ABF86826">
        <property type="protein sequence ID" value="ABF86826"/>
        <property type="gene ID" value="MXAN_2689"/>
    </dbReference>
    <dbReference type="GeneID" id="41360067"/>
    <dbReference type="KEGG" id="mxa:MXAN_2689"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_7"/>
    <dbReference type="OMA" id="IELANTH"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="330"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="48465" checksum="11EF529B3E7D55A8" modified="2006-07-11" version="1">MVSSPLLDRIKKRDARVGVVGLGYVGLPLGMAFAEAGFPVMGLDVDKRKIDKIEKGESYIKHIPGAPLAELSKSGKLKATTDFAKAKDMDCVIICVPTPLTASREPDMSYIIQTGEALAPHVRPGQLFILESTTYPGTTEEVLKPLLEKNGLKAGKDFYLAFSPEREDPGNKSFNTKTIPKIVGGYSPECSEMAAALYGSALKEVVPVSSTRVAELTKLLENIFRCVNIAMVNEMKMLCDRMGVDVWEAIQAASTKPFGYMPFYPGPGLGGHCIPIDPFYLTWKAREYEFHTKFIELAGEVNWQMPYYVVQRTMEALNKNKQTLNGAKVLCLGAAYKKDIDDMRESPSLRVMTLLAEKGAELSYHDPYVPELHKGHGFNLEMKSVPLKPETLGQYDAVLILTDHSDIDYAMLVDRAKVVVDTRNATKGVSKGREKVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y6</accession>
    <name>Q1D8Y6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pdhC</name>
        <name evidence="11" type="ORF">MXAN_2668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 2 lipoyl cofactors covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a 24-polypeptide structural core with octahedral symmetry.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552738.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2668"/>
    <dbReference type="EnsemblBacteria" id="ABF88747">
        <property type="protein sequence ID" value="ABF88747"/>
        <property type="gene ID" value="MXAN_2668"/>
    </dbReference>
    <dbReference type="GeneID" id="41360044"/>
    <dbReference type="KEGG" id="mxa:MXAN_2668"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_7"/>
    <dbReference type="OMA" id="QVTVIKH"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF88747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="527" mass="55096" checksum="51320C2A91FF945E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D959</accession>
    <name>Q1D959_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552665.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2595"/>
    <dbReference type="EnsemblBacteria" id="ABF86903">
        <property type="protein sequence ID" value="ABF86903"/>
        <property type="gene ID" value="MXAN_2595"/>
    </dbReference>
    <dbReference type="GeneID" id="41359972"/>
    <dbReference type="KEGG" id="mxa:MXAN_2595"/>
    <dbReference type="HOGENOM" id="CLU_771230_0_0_7"/>
    <dbReference type="OMA" id="GIRGVWD"/>
    <dbReference type="OrthoDB" id="961460at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="370" mass="38800" checksum="E663F80FD9C484E9" modified="2006-07-11" version="1">MEILEMQLRKTLGAAALVTAATMASMAGCSGRDDDTDPLPDAGCLGTCSPDSGTGDAGTGDAGTGDAGTGDAGIQTVTIREARLLGDRPQIILEGVVVTTVVYVSSKDTGVSADFWVADPNNAQDGIFVQKYRTDPPTTYVPAKGDIVTIQGYVQNNSRFRDREGYRKVLKNNFDFRGASEATPMVITKTGTMTAPNDIAVSIDNGFGNADGGVGRPNLEHLGARVHIQGPLTLTDANPMAMKRLATPDDGEDTMHFGFEVSGGVLVNNLTTFGTTTDGGTPRCDYRVMVNDGGSVTFPDGIRGVWDTFTHAPCMDGGTSTFSCFNDAGVIPGTTNTWTTVLYPEGCDDLQGVVTEPETFRPAAPGAQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D979</accession>
    <name>Q1D979_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552645.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2575"/>
    <dbReference type="EnsemblBacteria" id="ABF88410">
        <property type="protein sequence ID" value="ABF88410"/>
        <property type="gene ID" value="MXAN_2575"/>
    </dbReference>
    <dbReference type="GeneID" id="41359953"/>
    <dbReference type="KEGG" id="mxa:MXAN_2575"/>
    <dbReference type="HOGENOM" id="CLU_153181_0_0_7"/>
    <dbReference type="OMA" id="CNCQPEP"/>
    <dbReference type="OrthoDB" id="1753049at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="14743" checksum="3313D43C62925B1F" modified="2006-07-11" version="1">MPRSHASITLHGMVRARWFSWLIGFGLFAACDQAPRMERAVDDCQAEQVSLKVEVLSAEGARVRGATVTGTNVTSNVSITGVTDDQGVSTAINESLAPSAVRVVATAGAKVSDAQQVEWVCDTCNCQPEPATLQLQLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B2</accession>
    <name>Q1D9B2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2542"/>
    <dbReference type="EnsemblBacteria" id="ABF86339">
        <property type="protein sequence ID" value="ABF86339"/>
        <property type="gene ID" value="MXAN_2542"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2542"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_7"/>
    <dbReference type="OMA" id="FAPFWGR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="6"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="43750" checksum="9F80FEDDD9787AF5" modified="2006-07-11" version="1">MRRAASLRVVFGIVALDLIGFGILIPQLGVYGVRFGASPFTVGLLISVFSLMQLVSAPILGRLSDRYGRRPVLLVSQVGSLLAYLLFAFAQSLPLLFLARVIDGISGGNISTAQAVVADITTPKDRARGMGVIGAAFGLGFVLGPALGGFLGAWGGNLAIGLFAAGLVAINLTGTYFYLPETRVEGRPGEGHARTLKGATLAMSLPVVGRCLVLMLVFTTAFAQMEGTFSVYLLTRFLSSGPVPLQEGGLFLRAAVTDLDVLREASLRSGWLFAAIGVISAGVQGGLVRRLTGGPGSAPGREALLATVGFGLTAAGLALLPVAPDYAWLFPVMGLLAVGSALVTPCLSALVSLHAPPERLGAVLGAYQAFGSLGRILGPALGGWLFTRLGPAAPYGTAAGMVAMAGLLGLSLVAQTRMAGAGAEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E3</accession>
    <name>Q1D9E3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2511"/>
    <dbReference type="EnsemblBacteria" id="ABF89529">
        <property type="protein sequence ID" value="ABF89529"/>
        <property type="gene ID" value="MXAN_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2511"/>
    <dbReference type="HOGENOM" id="CLU_214924_0_0_7"/>
    <dbReference type="OMA" id="YGPQQPR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="56" mass="5944" checksum="7CE3153845B53C46" modified="2006-07-11" version="1">MRCGGMMNDMADRWIQRVTLAAMVAMAAALLTVGARLYGPQQPRPPAGAADSVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9X9</accession>
    <name>Q1D9X9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2324"/>
    <dbReference type="EnsemblBacteria" id="ABF91799">
        <property type="protein sequence ID" value="ABF91799"/>
        <property type="gene ID" value="MXAN_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2324"/>
    <dbReference type="eggNOG" id="COG3228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063037_0_0_7"/>
    <dbReference type="OMA" id="EHSGEAW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd20169">
        <property type="entry name" value="Peptidase_M90_mtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010384">
        <property type="entry name" value="MtfA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042252">
        <property type="entry name" value="MtfA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30164">
        <property type="entry name" value="PTHR30164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06167">
        <property type="entry name" value="Peptidase_M90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="28060" checksum="095897721617D62B" modified="2006-07-11" version="1">MFSFIRQFRRRRLLRRPFPEAWLGYLDARVPFFRTLSPELRQPFLDKLKVFAWEKEFIGAGGLEVTDEIRVVISATAVQLVLHLGLSYYDRLREVIVYPSAFRIPDRTGGVLGEAKNWGSVILSWESVLAGLRNPGDGHDTATHEFAHVLDRADGAFDGTPNLRAYSHYRAWSAVMSEHFHKLQQGQRRERQVLDDYGGLNEAEFFAVATESFFEKPRQMQEKTPDLYEELKRFYGWDPAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA73</accession>
    <name>Q1DA73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2229"/>
    <dbReference type="EnsemblBacteria" id="ABF89351">
        <property type="protein sequence ID" value="ABF89351"/>
        <property type="gene ID" value="MXAN_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2229"/>
    <dbReference type="HOGENOM" id="CLU_159803_1_0_7"/>
    <dbReference type="OMA" id="HIARLRW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14345" checksum="C2FE92D458086D21" modified="2006-07-11" version="1">MHLPGHLPRALKAAYLPGGRDSPAPEGDPPLRIVVREVGGVFMRYITQIRLEGGALHEHIARLRWKEGNEVGEGSRLELVQWLKAGGDARVQTWPRDVKVEVIDARPPYLRTKANGILTDNLLELPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAQ1</accession>
    <name>Q1DAQ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552127.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2043"/>
    <dbReference type="EnsemblBacteria" id="ABF92019">
        <property type="protein sequence ID" value="ABF92019"/>
        <property type="gene ID" value="MXAN_2043"/>
    </dbReference>
    <dbReference type="GeneID" id="41359452"/>
    <dbReference type="KEGG" id="mxa:MXAN_2043"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_7"/>
    <dbReference type="OMA" id="INHAHLG"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="35951" checksum="8CD493BD700C8C27" modified="2006-07-11" version="1">MKAMVLCAGLGTRLRPLTERWPKPAMPFLGQPLLRYHLAVLKAAGVTAVGINTHHLPDTMEAVARAECARAGLPLHVVNEPVIQGTGGGIRGLRDFLSDGDFIVFNGDILYPVDLRPVVALHQASGALATMVLQPMPAGETYAAVELDAEGRVRRIAGHGPGGEGLSPWHFTGVHVMSPRVFDFMSPRGEEDINRGVYVRAMEAGQMVRGVRVDGYWSDLGTPSRYLATVQDVLAGHVRLEWLGADSPLAGTVRGASGTWAHAEARLDGTAEGPVYLGRGSAVAAGAAVGPGVSLEPGAKVAAGARLSRATVFEDTEVSSGESLSEVLAWGAHRIAAPLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB27</accession>
    <name>Q1DB27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1901"/>
    <dbReference type="EnsemblBacteria" id="ABF85862">
        <property type="protein sequence ID" value="ABF85862"/>
        <property type="gene ID" value="MXAN_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1901"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_1_4_7"/>
    <dbReference type="OMA" id="LACATIC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="19576" checksum="280634C4AC08D579" modified="2006-07-11" version="1">MEASTWRRASSTRTSPRRKRGALRRQTKRGKRTKVMAAADGAGLPLAIGTASASPHETRLLEATLDESLIDELPERLIGDKPYDADKLDERLWHQRGVKLIASHRRGRKTKTQDGRELRRYRRRWKVERLFAWLQNFRRLVTRYEVKVENFLGFLHLGCILILLRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB43</accession>
    <name>Q1DB43_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551986.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1884"/>
    <dbReference type="EnsemblBacteria" id="ABF87218">
        <property type="protein sequence ID" value="ABF87218"/>
        <property type="gene ID" value="MXAN_1884"/>
    </dbReference>
    <dbReference type="GeneID" id="41359299"/>
    <dbReference type="KEGG" id="mxa:MXAN_1884"/>
    <dbReference type="HOGENOM" id="CLU_1413845_0_0_7"/>
    <dbReference type="OrthoDB" id="1308229at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="22253" checksum="832FADEDE3471546" modified="2006-07-11" version="1">MTRLSRSKLWAEFLQRLASEMEPLAPMLHQGRRLVWRQGEWLNWVTLSRHSWPDRHFPEAPPVTRISMNRFIFEPSEAMLRRFGFSGVGLPLGERRLRLEWTVYGEELLAFASWLPLLIRGRLNATEPIPLPPHPSHVFNGGLRKTSYAWTATAWEAYARWKRTDASLPCVAIPAGRVKPARALTRTLRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB88</accession>
    <name>Q1DB88_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551941.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1839"/>
    <dbReference type="EnsemblBacteria" id="ABF87724">
        <property type="protein sequence ID" value="ABF87724"/>
        <property type="gene ID" value="MXAN_1839"/>
    </dbReference>
    <dbReference type="GeneID" id="41359256"/>
    <dbReference type="KEGG" id="mxa:MXAN_1839"/>
    <dbReference type="HOGENOM" id="CLU_1523576_0_0_7"/>
    <dbReference type="OMA" id="WHTNEAY"/>
    <dbReference type="OrthoDB" id="713755at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="19756" checksum="1CC87608FF2F631A" modified="2006-07-11" version="1">MALLNPSFEDAGARPGEAAHWTLTAVTRIEVLAGFGVPEEACEDFERWYVWHAALSDVPVALAFFSGQRDGFEAFSRGWDNDGFLFELPPAQLVPHRFEGNVAETWGHGPFLADWADATSVEGLFSDSPREDFEQRWHTNEAYAWRWEDVATRAALFNTTQPSEDFDTGWPVAATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB9</accession>
    <name>Q1DBB9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551913.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1808"/>
    <dbReference type="REBASE" id="13171">
        <property type="entry name" value="MxaDKORF1808P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92729">
        <property type="protein sequence ID" value="ABF92729"/>
        <property type="gene ID" value="MXAN_1808"/>
    </dbReference>
    <dbReference type="GeneID" id="41359224"/>
    <dbReference type="KEGG" id="mxa:MXAN_1808"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4889">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002151_1_0_7"/>
    <dbReference type="OMA" id="APMKRAV"/>
    <dbReference type="OrthoDB" id="45009at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039442">
        <property type="entry name" value="Mrr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13156">
        <property type="entry name" value="Mrr_cat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="178"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1656" mass="186070" checksum="0E9E3A3BD652018C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD3</accession>
    <name>Q1DBD3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551899.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1792"/>
    <dbReference type="EnsemblBacteria" id="ABF92807">
        <property type="protein sequence ID" value="ABF92807"/>
        <property type="gene ID" value="MXAN_1792"/>
    </dbReference>
    <dbReference type="GeneID" id="41359213"/>
    <dbReference type="KEGG" id="mxa:MXAN_1792"/>
    <dbReference type="HOGENOM" id="CLU_468364_0_0_7"/>
    <dbReference type="OMA" id="AGELHMM"/>
    <dbReference type="OrthoDB" id="127108at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="582" mass="63821" checksum="D51BFC2E0D9D6CB4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBI7</accession>
    <name>Q1DBI7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551845.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91445">
        <property type="protein sequence ID" value="ABF91445"/>
        <property type="gene ID" value="MXAN_1736"/>
    </dbReference>
    <dbReference type="GeneID" id="41359169"/>
    <dbReference type="KEGG" id="mxa:MXAN_1736"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_1_4_7"/>
    <dbReference type="OMA" id="DFVQSWS"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="28"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="386" mass="42934" checksum="B3937EEA325A26F8" modified="2006-07-11" version="1">MRGALHPPSHPQTSDAGVLDSGPSRKDGLDVLRALAIVSVLCFHAPESVRRALPEVLRAGFEVGWVGVDLFFVLSGYLIGRQVFAMEDSAPLGLQLRTFWLKRWMRTLPLYFVVLAFYALKPWLFGTPFVGGGWHYLVFLQNYVGVRDFVQSWSLCVEEHFYVVLPLIAFGLRARSAPAWAWLMPLLLSLGARAWEVHTATPGLLPAEQWVRLQWRTHLHLDGLAVGVFLAKTAPRWQRWPQAWRGACGAMGALLLGVTLAVCVPHLPDWGGVWIFAGLAVGFGGLLVATEAVALPVPLRGLVYQTAVLSYGTYLWFWVVARVFERRNLTLGVWGLDLLAFITVTHGVAWVTYVAVERPALRLRDRLLAWQASRAEARDGVVAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR3</accession>
    <name>Q1DBR3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD domain G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1658"/>
    <dbReference type="EnsemblBacteria" id="ABF86230">
        <property type="protein sequence ID" value="ABF86230"/>
        <property type="gene ID" value="MXAN_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1658"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356737_0_0_7"/>
    <dbReference type="OMA" id="QVLCAAF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="786" mass="85420" checksum="7816FB977F3FF366" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ4</accession>
    <name>Q1DBZ4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1577"/>
    <dbReference type="EnsemblBacteria" id="ABF91796">
        <property type="protein sequence ID" value="ABF91796"/>
        <property type="gene ID" value="MXAN_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1577"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="HDDKRVF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="313" mass="34159" checksum="ACD80DA947FCA33F" modified="2006-07-11" version="1">MVPAPSSVVRGLVPGQTVAQRYRVERWLGAGGSSTVYEATDLHQDMRVALKVLAVPHADAAMVARFRQEVEHARALEHVNILRVFDAGVDGERHFLTVELLDGVDLRQRLLERRATLAEALRWLTHATVALEHAHGRGVLHRDVKPANLFITRTGVLKLMDFGLAKSTHVMGTTAQGAVLGTPEYMAPEQVTGNPAVSPATDLYALGVVAYELFTGQLPFRHPEPVPLMFLHVQERPVPPRTLRPALPEPFERVVLRLLEKRPDDRYRSAAELRTALAKLWPHALNGDASVAARAPAPPLARARAPGPGGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC33</accession>
    <name>Q1DC33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551649.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89536">
        <property type="protein sequence ID" value="ABF89536"/>
        <property type="gene ID" value="MXAN_1539"/>
    </dbReference>
    <dbReference type="GeneID" id="41358983"/>
    <dbReference type="KEGG" id="mxa:MXAN_1539"/>
    <dbReference type="eggNOG" id="ENOG50319T6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820908_0_0_7"/>
    <dbReference type="OMA" id="PRGKMEP"/>
    <dbReference type="OrthoDB" id="1217172at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="35589" checksum="F672BCA0DC922D93" modified="2006-07-11" version="1">MKQSVFGLVVALSLTACKEEPRGKMEPIPRPPGMKDAPPPAEAAPAAAAEPPVDPSKVVLRWKIAQGAPSSYRLDIERTGGAPASTEEAAPPKSAKGKGKEKPAPVAAAPAVLPGPVTYFMERTDSGDYRLRVVPVGSNVDADTATLSERGFVLDGLQGATRNTATLVLELPRDPVGTGDVWSLGTELILMEALGPQFQAGQPERSNRVKLASLTPADGGEQVATLEYAISEKLAGKVRAKDEPPTSPARAEEEDAEADDSGRPRPRAAPETSASAEVSITGRGEFLVKAGRWRSWEGTVTSVTKGGFPTAALQVPTGALKLRLTAVESAPAPTPTAQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCA7</accession>
    <name>Q1DCA7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1459"/>
    <dbReference type="EnsemblBacteria" id="ABF89950">
        <property type="protein sequence ID" value="ABF89950"/>
        <property type="gene ID" value="MXAN_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1459"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141544_1_1_7"/>
    <dbReference type="OMA" id="FQSEDFQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="11059" checksum="09863CA32B884FBB" modified="2006-07-11" version="1">MPMIVAIARFRPAPEEADRLVARFQARTRAVDGYPGFLGLEELRSFERPPELMLVTRWRDKASMRAYFQSEDFQRAREASAQQEDATFALYEAVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB1</accession>
    <name>Q1DCB1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551571.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1455"/>
    <dbReference type="EnsemblBacteria" id="ABF92386">
        <property type="protein sequence ID" value="ABF92386"/>
        <property type="gene ID" value="MXAN_1455"/>
    </dbReference>
    <dbReference type="GeneID" id="41358901"/>
    <dbReference type="KEGG" id="mxa:MXAN_1455"/>
    <dbReference type="eggNOG" id="ENOG5032PHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426605_0_0_7"/>
    <dbReference type="OMA" id="GVRVTFK"/>
    <dbReference type="OrthoDB" id="1492020at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032577">
        <property type="entry name" value="DUF4920"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16267">
        <property type="entry name" value="DUF4920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="23315" checksum="0F7D9A7F049A74B0" modified="2006-07-11" version="1">MTTFKRTSSACANGWTLVRGSPCRSKDFWLSGRGMNTLRTSLMLLVAVPLVAAAGDKSSAKAGKAAEADCHHPPAPQAQTAPKAEGAPDGWKLTRGEPLKGAKAVKLADVLAKPQAHDGKTVLLEGQVRKACERKGCWMELAANGQDKGPGVRVTFKDYGFFVPLDSAGAQARVEGVLKVAELTDSRAQHYESEGAIVPRGADGKPREVQLVATGVELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ0</accession>
    <name>Q1DCJ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551493.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1376"/>
    <dbReference type="EnsemblBacteria" id="ABF92737">
        <property type="protein sequence ID" value="ABF92737"/>
        <property type="gene ID" value="MXAN_1376"/>
    </dbReference>
    <dbReference type="GeneID" id="41358822"/>
    <dbReference type="KEGG" id="mxa:MXAN_1376"/>
    <dbReference type="HOGENOM" id="CLU_492506_0_0_7"/>
    <dbReference type="OMA" id="WRNPRAR"/>
    <dbReference type="OrthoDB" id="367737at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="551" mass="59242" checksum="0DF039A54C66E127" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW4</accession>
    <name>Q1DCW4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RibD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551369.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1250"/>
    <dbReference type="EnsemblBacteria" id="ABF86527">
        <property type="protein sequence ID" value="ABF86527"/>
        <property type="gene ID" value="MXAN_1250"/>
    </dbReference>
    <dbReference type="GeneID" id="41358698"/>
    <dbReference type="KEGG" id="mxa:MXAN_1250"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_0_7"/>
    <dbReference type="OMA" id="IWLYGGA"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19945" checksum="DF826D441D826B61" modified="2006-07-11" version="1">MRKLKYHVATSVDGFIAHEDDTYGAFMQDRLIKDSEHVADYVASLATYATVLMGRRTYDGGLKVGVTDPYPNMDTYVFSRTMKESPNPRVKLVSDDAVGEVRRLKAQEGGDIYLSGGGAFAGLLLAEGLVDEVLLKMNPLILGSGILLASSLKQVVDLDLKSTKVYANGVVLLRYAVMPRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD27</accession>
    <name>Q1DD27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551306.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1187"/>
    <dbReference type="EnsemblBacteria" id="ABF90323">
        <property type="protein sequence ID" value="ABF90323"/>
        <property type="gene ID" value="MXAN_1187"/>
    </dbReference>
    <dbReference type="GeneID" id="41358637"/>
    <dbReference type="KEGG" id="mxa:MXAN_1187"/>
    <dbReference type="eggNOG" id="ENOG5031CQP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1382087_0_0_7"/>
    <dbReference type="OMA" id="RCDVTRP"/>
    <dbReference type="OrthoDB" id="1452468at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="22046" checksum="BC10BD8B9A8C4709" modified="2006-07-11" version="1">MDWPRKHVGRGLGTALIAVAGLHAPTVHAEEPRTTCTATLAGRRVMVRSEAFDFVSPELDRLVRLGMAGKLEVELTLWQRNTVWFDARMDTARLTQVLAFSKGAYVLDGRPLPEGPSSLTLERVAWTLEKRPEPGARYEVRISVRLHVVTAASLGRVAAWLTQGKQAPGEEGTTLTGTVLLRSVAEDLARGASARCDVTRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDI0</accession>
    <name>Q1DDI0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551153.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1032"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90912">
        <property type="protein sequence ID" value="ABF90912"/>
        <property type="gene ID" value="MXAN_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="41358486"/>
    <dbReference type="KEGG" id="mxa:MXAN_1032"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_1_7"/>
    <dbReference type="OMA" id="PMTEVGG"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="392" mass="42317" checksum="780FF1C25C4337BA" modified="2006-07-11" version="1">MTPRHATPQTAARLALLMDPREEGWPSMDLVGEALLAGLAAHPSEVHATAVRPDMPAVLRRLPRAGARNAAFNADRLLTRFGLYPGRALLARGRHDAFHVVDHTYAQLVHALPASRTGVYCHDLDAFRSVLEPRREPRPAWFRAMARAQLAGLERAAIVFHSTQAVRMELLAHGLVPESRLVWAPYGVSPEYRPVPTPGAPDASEAVLAPLGGRPYLLHVGSAIPRKRLDVLFAVFAALRARYPELRLVQQGGALNGTQRAQVEALGIGDALLQPPRQERATLAGLYRRATAVLVTSEAEGFGLPVIEALACGAPVVASDLPVLREVGAEACTYCPVGDVPAWVESVTALLAGHDTQPSREARLTRASRFTWSAHARTVLDAYLRLLGASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM4</accession>
    <name>Q1DDM4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cation efflux system protein CusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551109.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0988"/>
    <dbReference type="TCDB" id="2.A.6.1.8">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91882">
        <property type="protein sequence ID" value="ABF91882"/>
        <property type="gene ID" value="MXAN_0988"/>
    </dbReference>
    <dbReference type="GeneID" id="41358444"/>
    <dbReference type="KEGG" id="mxa:MXAN_0988"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="NSWTYPI"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="929"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116523" checksum="8270FDB6BD7C7532" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDN6</accession>
    <name>Q1DDN6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0976"/>
    <dbReference type="EnsemblBacteria" id="ABF87824">
        <property type="protein sequence ID" value="ABF87824"/>
        <property type="gene ID" value="MXAN_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0976"/>
    <dbReference type="eggNOG" id="ENOG5030DUI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061770_0_0_7"/>
    <dbReference type="OMA" id="WQYQNVA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023977">
        <property type="entry name" value="CHP04052"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04052">
        <property type="entry name" value="AZL_007920_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="33056" checksum="503E66C14F320257" modified="2006-07-11" version="1">MACGNLPRSPPVGIALRGDSISRESAMVSAHRRAVRMLPFALLGVLGCGDGMEVAIPFEARVGSEPFACGRIYTGVGTTGTTYEPMDLRVYLHDVRLVTADGIEVPLKLEQDGRWQTRGTALLDFADKAGLCTNGTQATNLRITGTAPEGTYTGLRFKLGVPETQNHLDVSTAPSPLNDTSLYWGWRSGYLFTRIEGRTKGLPEGHVMHLGSTDCAPPPEGQTNGTAGCTFGNRPEVALDSFDLASGKVVLDLGALFSGSNLDENAEVPNTSVGCMSQQADPDCAPVFSRMGLTHRSQELAPGPQAFIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT2</accession>
    <name>Q1DDT2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0930"/>
    <dbReference type="EnsemblBacteria" id="ABF87320">
        <property type="protein sequence ID" value="ABF87320"/>
        <property type="gene ID" value="MXAN_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0930"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="ESTFRIQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="473" mass="51043" checksum="3B1C570DF9848A27" modified="2006-07-11" version="1">MRHPMAADSESTFRIQARADLHASERAQSEPSRAQRGPGTLAGEYVLKALLASGGHGSVYEAEHRILGRRAAVKVLHPHLADQGEMLKRFVREARVVNQIRHPNIVDVYDFGLMPDGSPYYVMELLTGRTLSQVVQERGRLSSTRALAYLEPVCGALEAAHRAGVVHRDLKASNILVVEEGERPRVKLLDFGIAKLLHAEPSQEGLTIAGQRLGTAHAMAPEQFRGGPIGPHTDIYALGVLLHQLITGRYPFQCEDRMELERLHLEAPAPRPSAIAAVSPAVDAVVLRCLEKDGSRRFGSVTAFLAALSEAAEEPVQPTRRTRLALAVHAEVVLAASAQDDDAVYAVLADVLDGLEQGLRGGGFLLALQSGTSLLAVHPLDHGAPSAERTEYLREAERTLRVLQDMAQKLADPVNARVHLCVHLGQAETRGDSSESEVVGGPVTDVGTWRLRTADGFALTPAASLALEFDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDU9</accession>
    <name>Q1DDU9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551034.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0913"/>
    <dbReference type="ESTHER" id="myxxd-q1ddu9">
        <property type="family name" value="Est9X"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90714">
        <property type="protein sequence ID" value="ABF90714"/>
        <property type="gene ID" value="MXAN_0913"/>
    </dbReference>
    <dbReference type="GeneID" id="41358372"/>
    <dbReference type="KEGG" id="mxa:MXAN_0913"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_10_1_7"/>
    <dbReference type="OMA" id="LIHGGCW"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="91"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="28838" checksum="21589A9B5EDB6BE1" modified="2006-07-11" version="1">MSSMWVLETPAPTADARMAYGREPHQFGDLRMPEGPGPHPVVVVIHGGFWRAKYDLEHAGHLCADLTRRGFATWSLEYRRVGHDGGGWPGTLEDVARGTDFLRTLAQAHALDLSRVVALGHSAGGHLAAWLGARHRLRPGDALYSAAPLPLHGVVPLAGVVDLPRAFAHRLGDGIVETFLGGTPSSVPERYRTASPASLQPLGVAQVLVHGTEDDTVPVSMSEDFCARGRELGDDVRCVTLPGAGHFEVIDPRSREWPHVVAAVQSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE61</accession>
    <name>Q1DE61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="gene ID" value="MXAN_0799"/>
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        <property type="entry name" value="HisK_dim/P"/>
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        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF47384"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="12164" checksum="154DEAD915AE10A1" modified="2006-07-11" version="1">MTGICGRGALTRDAGAPASLAWTPCSCSSRASPRQTVVFREQFLGVLGHDLRSPLQAISVNRISVSADRMARMSNDLLDFTCTRLGGGYPEEGTRFRLCLPRFEKPDMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEG4</accession>
    <name>Q1DEG4_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_0691</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0691"/>
    <dbReference type="EnsemblBacteria" id="ABF91538">
        <property type="protein sequence ID" value="ABF91538"/>
        <property type="gene ID" value="MXAN_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0691"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLH55568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="493" mass="54614" checksum="5B9021D7454050E5" modified="2006-07-11" version="1">MPLAMVPGFTTCCCCCCCCCWTSVVGKLTLLTPMVSFTTGFRVAALLAKAPKSTVRAAGEASARIVRREPFFESSMRTSGGVVFVCDPSRSSRLTCPGVLIVHSLLTTYQDASRQKQTPHCRHEWNDFTRRPERRTRASGVPGPRDGLETGGAGDSGRRGRRRRGRLRRGRQGQPRELRRRASEHQTRSASEDLELEGRGRSGAPDEEDVRRAGDLLRVDAHDDVVLLEGPERHRRRLGDDHRADVTHRLEFDHQARTIGLHGDTVPRGTGAGGVHRGRPFTRGVRGMTRVCAGHEQTQNQDGTVHRRPSLWRWAAGRREERLRTRASRTAQRGPAVSDHQHGRQASWLRQKAAHEEIIQSRLPVKPQQPICECSHSAPARRGAKRQDSRLDPPVFPDKSHPHHRCLDSWLLHFMSQLGLSRHRRRPRASSLAPGRLGRTPPSTVSRRHGASAREELLGGACHVGRHGPQRVTPGVGVGAEEHGAAHAGEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEW3</accession>
    <name>Q1DEW3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">treZ</name>
        <name evidence="13" type="ORF">MXAN_0541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0541"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90802">
        <property type="protein sequence ID" value="ABF90802"/>
        <property type="gene ID" value="MXAN_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0541"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020726_2_0_7"/>
    <dbReference type="OMA" id="FTPMLFM"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="106"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="338"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="407"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="621" mass="68026" checksum="A4C395D6DE3CA72C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF53</accession>
    <name>Q1DF53_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0450"/>
    <dbReference type="EnsemblBacteria" id="ABF88769">
        <property type="protein sequence ID" value="ABF88769"/>
        <property type="gene ID" value="MXAN_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0450"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668742_0_0_7"/>
    <dbReference type="OMA" id="PSARIWT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="279"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="44205" checksum="AA55BDBB432AEDB5" modified="2006-07-11" version="1">MAWLTGNLSPSARIWTALAPAIVACTYFIGGLLLFCIRCAFKGIPRDEETLKRGSNGLVGFFLRHYFFWVIQPLWAVILRSGLPANALSMLSGLLGISSGVAVAAGRFALGGWLFLFAGILDVMDGRIARTRKEANPAGAALDSVLDRYVDSAMLMGLAWYYRDTWVLLPALMALLGSSLVPYVRAKGEGLGVNVRDGAMQRLERVLFMGAGTALSPILEAVFWPEEKHPMHWLAVVGLVFVAVMSNVTALSRFRNLVKALAPKRQEARSGKAIIGLNALAGAVATAVDFALVLALVEWAGVLPAWATVLGCGLGAVVNYSINRVLTFKSTGAVGRQLARYSVVSGTSALLNAGGVALLTLHPQLAYALGWWLVRGVVYFAWNLPLQRDYVFNNDAAASEDALMEQRPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF80</accession>
    <name>Q1DF80_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_0422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550556.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0422"/>
    <dbReference type="EnsemblBacteria" id="ABF92279">
        <property type="protein sequence ID" value="ABF92279"/>
        <property type="gene ID" value="MXAN_0422"/>
    </dbReference>
    <dbReference type="GeneID" id="41357916"/>
    <dbReference type="KEGG" id="mxa:MXAN_0422"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_1_7"/>
    <dbReference type="OMA" id="IKGASTC"/>
    <dbReference type="OrthoDB" id="357522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="41"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="164"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="288"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="10">
        <location>
            <begin position="474"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF92279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="604" mass="66139" checksum="50D42453D1B26379" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC4</accession>
    <name>Q1DFC4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550513.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0375"/>
    <dbReference type="EnsemblBacteria" id="ABF89156">
        <property type="protein sequence ID" value="ABF89156"/>
        <property type="gene ID" value="MXAN_0375"/>
    </dbReference>
    <dbReference type="GeneID" id="41357873"/>
    <dbReference type="KEGG" id="mxa:MXAN_0375"/>
    <dbReference type="HOGENOM" id="CLU_2521906_0_0_7"/>
    <dbReference type="OMA" id="CNDLEVC"/>
    <dbReference type="OrthoDB" id="1806570at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188477" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="9992" checksum="9B97FFABB766770B" modified="2006-07-11" version="1">MTTRANPGTTAAVRRALCGAFAAIAVGLFGCNDLEVCGSTASAITRDGGEPYRCVTSEDCPRTSRVNVCVTDVSPVEVCVRCQDTKCVTVTPEACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFI3</accession>
    <name>Q1DFI3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89671">
        <property type="protein sequence ID" value="ABF89671"/>
        <property type="gene ID" value="MXAN_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0310"/>
    <dbReference type="HOGENOM" id="CLU_544930_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="53732" checksum="35E18B817A65E708" modified="2006-07-11" version="1">MDDVLVDGAGQLVPCEQLLHEHRHLIHALLGGAQVHAGQALVQLMAQRRHLAPDGRVRVVVAHGHVEHVPQPGHAVLEEHAVALHLEEGAARVGHQLLVQHPGGNLPEVLQLHGAVAAEEGHGLREVEDGLVRAHADAVLRLRAEVDLLVQRALLVAHRGHRLPGQLERVLVLELEARRGHAAEVQLPQEEGDALQHVLGHLHFQDGGVGALQLARREDDFLGQQLLGGLVGLQALEELVHEARVEGHRAHHHVDAVLQRLDDLEGAAALVVVGGEEPGRAARVDVLVHHLRVALRHEGQERGLRLGGDAVVLVDDFDALANPLAPAHLHRGQVLRLEHVGGQRRAQQVRDGELRVPALDAAVDLVAAHAGQQGHEDGGRRLPASRSAHQQRAPAGEEGEQGDEDERAVAGVLGEVELVTRRRLEGRGRAELQVVVGTDDGVVGDPPIRLPHLVVEAAAVALGEVDIELLVRRRAPGEQARHPVLVGHARRSLSPRGNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK0</accession>
    <name>Q1DFK0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550437.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0293"/>
    <dbReference type="EnsemblBacteria" id="ABF90896">
        <property type="protein sequence ID" value="ABF90896"/>
        <property type="gene ID" value="MXAN_0293"/>
    </dbReference>
    <dbReference type="GeneID" id="41357792"/>
    <dbReference type="KEGG" id="mxa:MXAN_0293"/>
    <dbReference type="eggNOG" id="COG5207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163943_1_0_7"/>
    <dbReference type="OMA" id="WGWCYVD"/>
    <dbReference type="OrthoDB" id="1674309at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="97" mass="11066" checksum="3D4CFF27AF203B89" modified="2006-07-11" version="1">MEPICEHIRQAEDPPPRSRGCEECLAMGASWVHLRRCLSCGHVGCCDSSPNRHATKHFQQSAHPVVQSFEPGEEWAWCYEDELFTEHRPAPSHDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFW8</accession>
    <name>Q1DFW8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550319.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DFW8"/>
    <dbReference type="STRING" id="246197.MXAN_0172"/>
    <dbReference type="EnsemblBacteria" id="ABF89084">
        <property type="protein sequence ID" value="ABF89084"/>
        <property type="gene ID" value="MXAN_0172"/>
    </dbReference>
    <dbReference type="GeneID" id="41357675"/>
    <dbReference type="KEGG" id="mxa:MXAN_0172"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="DMSPAIQ"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="148"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="49727" checksum="AFD2B39634D5FF61" modified="2006-07-11" version="1">MDIGERPMRVLVVDDERNIRHTLRVCLEGFGCEVREAATPEAALAALAQGPADLAFVDLRLGTASGMELLPRLLAESPHLDVVLITAYATFDTAVEAMRRGARDYLPKPFTPAQIRHAVEKARRHQELASQLENLEGQLSQAVPEATLETASPAMHAAIGLLTRAAASDAAVLLRGESGTGKGVLARALHSMSARRRRPFVTVNCPTLSEQLLASELFGHVRGAFTGAVKDQPGRVEAAEGGTLFLDEIAEMSPGLQAQLLRFLQEKQFERLGEGRTRKADVRVVAATNRDLEKDVAEGRFREDLLYRLNVIEVKLPSLRERPEDLLSLARRFVSFFARAAQRPPPELSPATEKMLLAYGWPGNVRELRNAMERALIVWPAEVLEPQAFPDRIAAAGSPVMTLGGPHTLEDIEREHVLRVMASAPTLDEAARVLGIDASTLWRKRKKYESGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY4</accession>
    <name>Q1DFY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550303.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0156"/>
    <dbReference type="EnsemblBacteria" id="ABF92352">
        <property type="protein sequence ID" value="ABF92352"/>
        <property type="gene ID" value="MXAN_0156"/>
    </dbReference>
    <dbReference type="GeneID" id="41357659"/>
    <dbReference type="KEGG" id="mxa:MXAN_0156"/>
    <dbReference type="eggNOG" id="ENOG502ZC53">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110670_0_0_7"/>
    <dbReference type="OMA" id="EEHRHAY"/>
    <dbReference type="OrthoDB" id="1271828at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="27877" checksum="B2BAB7FDF021E3D4" modified="2006-07-11" version="1">MKPSPRADQKGPPTPFPGVGPVFGLAMGPGAGLEDGLMRDRIQAVLRQLAQSPDMEARWLHTLSLMEFIGARKISRTVADRHPTLEVLGHLADETRHAFAFKRLSAEVAGAEITTFLCPEAAGRYFQALDHELATWATSFTGAPDVYLHYLLTTTAIERRAMVLYPLYKAASRQPAVREELGRVVTEEQSHRLTIEDACVERLTAVGATLDAALALEERLFAAFIGELEATVARESGAQAAFVPAPGEDVAARSQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFZ0</accession>
    <name>Q1DFZ0_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0150"/>
    <dbReference type="EnsemblBacteria" id="ABF90328">
        <property type="protein sequence ID" value="ABF90328"/>
        <property type="gene ID" value="MXAN_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0150"/>
    <dbReference type="HOGENOM" id="CLU_144766_0_0_7"/>
    <dbReference type="OMA" id="SGHEMQG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="15187" checksum="FDB454F68A2172D8" modified="2006-07-11" version="1">MKRAPGRPAGAWADMCNGRGGGVQHARVASSLGPVATQGGNAMQAFNRWMVLGAVAVAMSITGCREQNREHQGTTTTPGMEGTGGSGQGTKPHPSGGTGGTGGSGHEMQGYDAGTGGSGHEMQGYDAGMGGSGMMNDHNTKDTGTHSPEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG83</accession>
    <name>Q1DG83_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550206.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0057"/>
    <dbReference type="EnsemblBacteria" id="ABF88496">
        <property type="protein sequence ID" value="ABF88496"/>
        <property type="gene ID" value="MXAN_0057"/>
    </dbReference>
    <dbReference type="GeneID" id="41357566"/>
    <dbReference type="KEGG" id="mxa:MXAN_0057"/>
    <dbReference type="eggNOG" id="COG2913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545985_0_0_7"/>
    <dbReference type="OMA" id="SAWNVDP"/>
    <dbReference type="OrthoDB" id="1558023at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="19033" checksum="CD762CA83C451665" modified="2006-07-11" version="1">MLHPRYEDCMSGDVSATETTPKADAASGLFTAFQKDRKVPRGRWAGALLMALIPVVLGVGFWTLAKGEEKTFRIVTPQGFKSMRGGMTTEQVRAVLGRPITLERDTNGAECYRYGQPNFVNPQFLIYSVCYEDGKLRDVKTHQYSAWNVDPATGTFAAPGEEPADAAPVPAQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL1</accession>
    <name>Q1CVL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat/fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557365.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7458"/>
    <dbReference type="EnsemblBacteria" id="ABF86546">
        <property type="protein sequence ID" value="ABF86546"/>
        <property type="gene ID" value="MXAN_7458"/>
    </dbReference>
    <dbReference type="GeneID" id="41364605"/>
    <dbReference type="KEGG" id="mxa:MXAN_7458"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265258_0_0_7"/>
    <dbReference type="OMA" id="CESFLAN"/>
    <dbReference type="OrthoDB" id="1715972at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187948" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="162"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="254"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="347"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1267" mass="132479" checksum="B11E4D44270F0FF0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS2</accession>
    <name>Q1CVS2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557306.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7394"/>
    <dbReference type="EnsemblBacteria" id="ABF89028">
        <property type="protein sequence ID" value="ABF89028"/>
        <property type="gene ID" value="MXAN_7394"/>
    </dbReference>
    <dbReference type="GeneID" id="41364552"/>
    <dbReference type="KEGG" id="mxa:MXAN_7394"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610877_0_0_7"/>
    <dbReference type="OMA" id="CQATERE"/>
    <dbReference type="OrthoDB" id="423207at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="146"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="310"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="49424" checksum="D43E780E1AF235D8" modified="2006-07-11" version="1">MAIVCVTNLSPESLAAAHVAAAVAGRLQESLLLLGVAEGDAFLDDGTGALVLTQQRLEAEAARLETLARVVHYRLQAGTSADEVLSDEECRHARWIVVAASGWRTPAWRRATVPERLSRYGCAPVLAVRSDTALTDWARGRRRLLVLVGVDPGSSTTGAAVSFLRELRRVGPCDVLATYVCSPMDERERLGIHSPVHVELLEPALQGMEALDPIVERVLQREVREQVGDLVGEGRVEVVLEPGFGRPADHLMHVAHTRGADLMVVGTHQRSGVKRLWHGSVSAGVLRHAAQSVVCVPPMVQARRADRPPRSVLVPVDFSEACTKAISHARTLVGPGGRVHLLHVHRRKLEDRGFADHYGVLPEPARDRDQVLQRLWELVPRDETAQTVRWSVEGVTGEDVTLAICQATEREGVDLVCVGTSLEPSRLRDALEGEVAHELVTRCRRPVMVVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU6</accession>
    <name>Q1CVU6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7370"/>
    <dbReference type="EnsemblBacteria" id="ABF89832">
        <property type="protein sequence ID" value="ABF89832"/>
        <property type="gene ID" value="MXAN_7370"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7370"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_2_0_7"/>
    <dbReference type="OMA" id="GDHACSP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="42966" checksum="DC8049EDC3D3EA9F" modified="2006-07-11" version="1">MMPEEGLHPLMLQESEEVGAFRIVRRLATGGFGAIFLAESETRRQVALKFALQGPSEEDSPAADARTWKEVHVLMRLEHPNVVELLGYRRWPDARDGYLVLIMGYVEGPTLSEWALAAQPTPRRAVQVFQQLALTLDAIHRAGVLHRDIKGNNIIIRASDGQPVLVDFGSGDHACSPVLTEDTLPPGTPSYRSPEALRFWAQPRPAGSRYAFAPTDDLYSLGLVLYEVLTGSFPYPTQLPPAGLLASIESGGFPLPSVRNPRVPKALDAIVARLLSPSAAGRPPSGAALFDALDAALAGADSAWDEHLFPPLAPEEAVTEEALEFFDGDEEARELRHWMRVPERARPPASFAPPTEPASPWALTEVRASTGWRRWRDALKRLWATLRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW69</accession>
    <name>Q1CW69_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclic nucleotide-binding/patatin-like phospholipase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557160.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7241"/>
    <dbReference type="EnsemblBacteria" id="ABF92849">
        <property type="protein sequence ID" value="ABF92849"/>
        <property type="gene ID" value="MXAN_7241"/>
    </dbReference>
    <dbReference type="GeneID" id="41364407"/>
    <dbReference type="KEGG" id="mxa:MXAN_7241"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445313_0_0_7"/>
    <dbReference type="OMA" id="GGVWGFY"/>
    <dbReference type="OrthoDB" id="284349at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="353"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="357"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="384"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="501"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="643" mass="68884" checksum="6346E610E5FAF80E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW70</accession>
    <name>Q1CW70_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557159.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7240"/>
    <dbReference type="EnsemblBacteria" id="ABF91182">
        <property type="protein sequence ID" value="ABF91182"/>
        <property type="gene ID" value="MXAN_7240"/>
    </dbReference>
    <dbReference type="GeneID" id="41364406"/>
    <dbReference type="KEGG" id="mxa:MXAN_7240"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="REYPKMT"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
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        <property type="entry name" value="Acrflvin-R"/>
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        <property type="entry name" value="HAE1"/>
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    </dbReference>
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        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACRIFLAVINRP"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="869"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112283" checksum="06936EE1419BB2B0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF3</accession>
    <name>Q1CWF3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7157"/>
    <dbReference type="EnsemblBacteria" id="ABF91409">
        <property type="protein sequence ID" value="ABF91409"/>
        <property type="gene ID" value="MXAN_7157"/>
    </dbReference>
    <dbReference type="GeneID" id="41364331"/>
    <dbReference type="KEGG" id="mxa:MXAN_7157"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_7"/>
    <dbReference type="OMA" id="LGTHLNQ"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="26932" checksum="B5AE3CCECE141D07" modified="2006-07-11" version="1">MSDTLLTKLDSGVLTLTFNRPEKKNAFTHAMYEAATRALKDAEGNVDVRAVLLTGAGNVFTAGNDIGDFMEHPPAGEDSAVFRFLRALVDADKPILAAVDGPAVGIGTTMLLHCDYVVASERARFHMPFVQLGLCAEGASSLLIPRTAGFALASELLLFGEPFDAATALRAGLINKVVPDASLQQVATERAATLASRPAEAVRVTKRLIREPLRAQIRETLAREGGEFIQRLQSTEAQEAFMSFMSRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ9</accession>
    <name>Q1CWQ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87058">
        <property type="protein sequence ID" value="ABF87058"/>
        <property type="gene ID" value="MXAN_7051"/>
    </dbReference>
    <dbReference type="GeneID" id="41364227"/>
    <dbReference type="KEGG" id="mxa:MXAN_7051"/>
    <dbReference type="eggNOG" id="COG4911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137908_1_0_7"/>
    <dbReference type="OMA" id="PAVSHWH"/>
    <dbReference type="OrthoDB" id="1777117at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17928" checksum="546CBEA69598C7D1" modified="2006-07-11" version="1">MGDRQTSPPRQDSSGDGPYRCMLEGMRYFSVEEANRLVPLLTRTFERVRPWVERAQQLADELGAAPKPNDPSLASLRDERDTLLERIRGELLQLQEMGLEIKGADGLVDFRAHRGGEQVYLCWRFGDPAVSHWHALLDGFSGRRPIESPDDFAPTYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR0</accession>
    <name>Q1CWR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556969.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7050"/>
    <dbReference type="EnsemblBacteria" id="ABF91397">
        <property type="protein sequence ID" value="ABF91397"/>
        <property type="gene ID" value="MXAN_7050"/>
    </dbReference>
    <dbReference type="GeneID" id="41364225"/>
    <dbReference type="KEGG" id="mxa:MXAN_7050"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073040_0_0_7"/>
    <dbReference type="OMA" id="NEGRCAP"/>
    <dbReference type="OrthoDB" id="1539910at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="37635" checksum="9FC4A67B9AB29E7F" modified="2006-07-11" version="1">MSSHPTSQLGLFDTAATECADVEAEPRASTSVQRRLPAREEARPLAAERPVSTGVQRRHPSGEEVLPLATEQRAGTSAEDRRPVHERDEALPLATEQRASSVPESRLPAREEALPLAADLARRLSSILGLPVHLRLTDNRATLVSFRRGEEGLRLRIHHLFLGAPDAVVQAMAAYAGRADAQAGEVLESYAHAHNERVRRERRPGKPLRTRGRCFDLQAIFTRLNASWFDGRVQVDVGWARKPAGTKRRSIHVGGYDARLREIRIHPALDRPHVPAFVVDYLVFHAMLHADLDDGTGNEGRCAPEHTSAFREREALFPLRDTAQRWLGDNHASLLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWT9</accession>
    <name>Q1CWT9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556940.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7021"/>
    <dbReference type="ESTHER" id="myxxd-q1cwt9">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86539">
        <property type="protein sequence ID" value="ABF86539"/>
        <property type="gene ID" value="MXAN_7021"/>
    </dbReference>
    <dbReference type="GeneID" id="41364197"/>
    <dbReference type="KEGG" id="mxa:MXAN_7021"/>
    <dbReference type="eggNOG" id="COG4947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090325_0_0_7"/>
    <dbReference type="OMA" id="NREYHRW"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="27540" checksum="3132B46658CA34C1" modified="2006-07-11" version="1">MNREYHRWYSERLHRDMELLIFGHSGEPVLLLPTSKGRFFQAEDFGLIGAIADRVQSGRYIVVCPDSVDEESWFNTAIHPADRVRRHQQWEEYLLHEVVPLLKSRSTGGRLTLAGCSFGGFHAYNVGLRHPHVFRRLLSMGGKFETNEFLDGHHDADVYFHSCTEWLPNLTDPAQLSALQRVEMVLAVGEHDFCRPSNEHLSNLLWKKDIGNHLAVWQGGTHDWPVWRQMIQQYLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWW7</accession>
    <name>Q1CWW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556912.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90345">
        <property type="protein sequence ID" value="ABF90345"/>
        <property type="gene ID" value="MXAN_6993"/>
    </dbReference>
    <dbReference type="GeneID" id="41364169"/>
    <dbReference type="KEGG" id="mxa:MXAN_6993"/>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077096_1_0_7"/>
    <dbReference type="OMA" id="RCTYNGV"/>
    <dbReference type="OrthoDB" id="917815at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008164">
        <property type="entry name" value="XGLTT_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01744">
        <property type="entry name" value="GLTT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="35796" checksum="03A366BC6337A0F2" modified="2006-07-11" version="1">MYHHPTSKTCSSSKVTYAGRRCAHRWELLPALLLVAAVGCGPAEPMDTASETLGTQSDALVSSNGLSTNGLSTNGLSTNGLSTNGLSTNGLSTNGLSTNGLSTNGFSTWFSADPVKAEEVMRYIVRCALASGQSLTYTHAGTTHTWQGSLGLAPTWSNPTPPPPSSPGAPVAPEPEQQLVSSCLAAHVNKYGVHLNISVQGKDSQGVVIPTTAEEVQTYNQNEAVFFGNLFNGQGLFAANDAPYLAYDESTVRACGLSSWSGDPDCAAVITHVGAALTYCQQDSTRTYYTRCTYNGVTYRPLTTRIRPQDIYKCGDGTCQLSESCGTSNTPDSCAADCGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXE3</accession>
    <name>Q1CXE3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556738.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6813"/>
    <dbReference type="EnsemblBacteria" id="ABF88178">
        <property type="protein sequence ID" value="ABF88178"/>
        <property type="gene ID" value="MXAN_6813"/>
    </dbReference>
    <dbReference type="GeneID" id="41364002"/>
    <dbReference type="KEGG" id="mxa:MXAN_6813"/>
    <dbReference type="eggNOG" id="COG4340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078728_0_0_7"/>
    <dbReference type="OMA" id="WQPVEYN"/>
    <dbReference type="OrthoDB" id="597962at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018724">
        <property type="entry name" value="2OG-Fe_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10014">
        <property type="entry name" value="2OG-Fe_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26807" checksum="83A78E07E2C66142" modified="2006-07-11" version="1">MSFQPPVTPTSEVPTALREHGYAVLTRDGLCELAGIDSPALDALRPSWNELPLDGFLRDGGRYRSRRHSCFIVDGDALTQVPHRAHWQPVEYNALHGGMERWFEPVQPDIVSQPVWAGLIRGIAACCSQLKGERPWYVEAHQFRIDTTDGIGRPTPEGAHRDGVDFVAVLLVGREGIKGGETRVFEADGPNGLRFTLTEPWSALLLDDARVIHESTPIQPQGDTGHRDTLVLTFRAGGFQGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI6</accession>
    <name>Q1CXI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556695.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91896">
        <property type="protein sequence ID" value="ABF91896"/>
        <property type="gene ID" value="MXAN_6770"/>
    </dbReference>
    <dbReference type="GeneID" id="41363960"/>
    <dbReference type="KEGG" id="mxa:MXAN_6770"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537276_0_0_7"/>
    <dbReference type="OMA" id="WVAGGED"/>
    <dbReference type="OrthoDB" id="276434at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="546" mass="58309" checksum="286931B583D7EBDD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXV8</accession>
    <name>Q1CXV8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6648"/>
    <dbReference type="EnsemblBacteria" id="ABF92091">
        <property type="protein sequence ID" value="ABF92091"/>
        <property type="gene ID" value="MXAN_6648"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6648"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082992_0_0_7"/>
    <dbReference type="OMA" id="YWTVREA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="127"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="31460" checksum="30F8375415F0D2C1" modified="2006-07-11" version="1">MSCRARAGSRRAAAERRFIPRAFPFPVGTCAQATRQRWQGSPPRQFLPAVAATRAGVRPPGIGVDCAVAEGRLQASVRRVPPTSLTPRTARLFRLLMVGAGVLTCGVFGLAWVVDRFGQREQAAPADVLVVLGARVLPGGVPSGALRARTEHAVALYHRGVAPRLVFSGGVGVNPPSEARAMLALATRMGVPAEACVLEEGSHSTDDNARLTAEVLRGLGARRVVVVSDPYHLLRARNYFRLYGWEVATSPALETERNLDTFDRIYWTVREAVALLLHPRVLLARAPTPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY01</accession>
    <name>Q1CY01_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FliB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556530.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6603"/>
    <dbReference type="EnsemblBacteria" id="ABF91281">
        <property type="protein sequence ID" value="ABF91281"/>
        <property type="gene ID" value="MXAN_6603"/>
    </dbReference>
    <dbReference type="GeneID" id="41363802"/>
    <dbReference type="KEGG" id="mxa:MXAN_6603"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658435_0_0_7"/>
    <dbReference type="OMA" id="KREDGHC"/>
    <dbReference type="OrthoDB" id="1674644at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="46380" checksum="62A82869261A66B2" modified="2006-07-11" version="1">MTATAPRYMTRFRCLADACEDTCCAGLVVLVSEPRLQRLKQAVAGTPDAERVETFIRLEPDASPGDDAVIAKREDGHCVFLDARKTCSLHRAYGEAALPDACATFPRVATRWAHGLEVTGSLACPEVARLCLLAEDAVDTVPVSEDLALRPETARSLGGGDSEDAWTQHAAAVRSTALSVLQRRELPFAARLFALGQLGLRLDGFYCRGTEVFHGDAREGAEALLTEVLRAFTLPETLTALHGGFAALSLPGGPWVGICAAVLKSRLGAVRSERFLTLAELVLESYGGVDLLPDDAWRRYSERRERLSPGLAQRVEQYLRHHAVNHWLRHPFTDAPRVLDYVFRMALREAVLCWTLFGHPTVVALCAEVAADTAESRARLDAAAVECFQLIAKHVEQAPQLHALAQGLAGSGGDETLGRMLVLLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY32</accession>
    <name>Q1CY32_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferrichrome ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556499.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6569"/>
    <dbReference type="EnsemblBacteria" id="ABF90231">
        <property type="protein sequence ID" value="ABF90231"/>
        <property type="gene ID" value="MXAN_6569"/>
    </dbReference>
    <dbReference type="GeneID" id="41363774"/>
    <dbReference type="KEGG" id="mxa:MXAN_6569"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_7"/>
    <dbReference type="OMA" id="HEFTWDF"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27696" checksum="2B7B693C6138A903" modified="2006-07-11" version="1">MEPLLVTRALVAGYGPRPILHGVACEVRPGELWAVLGPNGTGKSTLLRAVLGLGPWTRGEVRLLGRERAAWEPRALARKVAWVPQTIESTEGFSGLELVLMGRSPHLGLWGLPSAADVALAREVMTELGIAHLSERPAEALSGGERRMLMLARGLVQQPELLLLDEPTAFLDVAHQVGSLDRVRARVDAGLGAVAVLHDVNLAAAFATHVLLLRDGQVLAQGPANEVLERGSLETLYGLPMETALAPSGARLFAPRAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF1</accession>
    <name>Q1CYF1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556380.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6448"/>
    <dbReference type="EnsemblBacteria" id="ABF86754">
        <property type="protein sequence ID" value="ABF86754"/>
        <property type="gene ID" value="MXAN_6448"/>
    </dbReference>
    <dbReference type="GeneID" id="41363655"/>
    <dbReference type="KEGG" id="mxa:MXAN_6448"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OMA" id="PPGRWEK"/>
    <dbReference type="OrthoDB" id="1412466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="24906" checksum="44DE8F973F3278BD" modified="2006-07-11" version="1">MRTCLLRMLPVLAVLWLGCSTSVKPPMQQAWDDAELECWTPHEDQCVSLLCLGDACGFYRCTDLPGEVELARFPPARPPVAAAAPGRGPRRNWGLGQQLPRGAVMVFPSWGGAPGRVIPPSHRLPPGRWEKHHIFPQAPELAQWFTQRGVKIHDYTMPIPRELHRRIPGGAGAGGAWNEAWRAYMRRNSGASPEEIFKHAGELIYRFELLGGPIRPYYSRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYN5</accession>
    <name>Q1CYN5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556296.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6364"/>
    <dbReference type="EnsemblBacteria" id="ABF88364">
        <property type="protein sequence ID" value="ABF88364"/>
        <property type="gene ID" value="MXAN_6364"/>
    </dbReference>
    <dbReference type="GeneID" id="41363577"/>
    <dbReference type="KEGG" id="mxa:MXAN_6364"/>
    <dbReference type="eggNOG" id="ENOG5033DN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107128_0_0_7"/>
    <dbReference type="OMA" id="VWPLELR"/>
    <dbReference type="OrthoDB" id="1997168at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="29794" checksum="A6176DF79F7FDEC9" modified="2006-07-11" version="1">MPGVVEGRTSLRPAGQYLHLEAGDTLQVRKAPGCEWPGSTGPGRGVRMIDEVDQRLKAWVGRIAGDVPVFLGVPDRESLERGVCLYLLELGPAPPVRSGGGGRASLQISVCYLITAGAESPERAHRLLGELVFAAMEEADFEVELTPVPTTVWAGLRTAPRPCFRLRVPVRRERSMPVIHRVLFPATPQATPTPAEALLGCVVGPGDVPIPGALVELPTLKLTTRTDAKGCFRFPSVPPVATLGRLEVRAKGALLELGPEVLAAEPQPLLIRLPLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV7</accession>
    <name>Q1CYV7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556225.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6290"/>
    <dbReference type="EnsemblBacteria" id="ABF89780">
        <property type="protein sequence ID" value="ABF89780"/>
        <property type="gene ID" value="MXAN_6290"/>
    </dbReference>
    <dbReference type="GeneID" id="41363508"/>
    <dbReference type="KEGG" id="mxa:MXAN_6290"/>
    <dbReference type="eggNOG" id="COG4912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061369_0_0_7"/>
    <dbReference type="OMA" id="RLQWAMN"/>
    <dbReference type="OrthoDB" id="1933111at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="41905" checksum="A67F40676DE5D452" modified="2006-07-11" version="1">MGGDWRPRTSPGRLSVLRFRLEWRQRRGGSLARMISRRWASTRAGYARLVASFRFPWLRCHIRMAAPSLPKLRGGSERKWFSTEGACGATLPAALKPPPVEVLPMPKTMSLSQVMKLLEGHGDEKVRQRYVRDGVVDNVFGVLLGKIRGLAATLGTNHGLGLELWGTGNHDARILACMLLDPAALTEKEARGLLEPLSNPTLVDELVGRVLVHAPVAPKLQEKWMDGSKELPRRAGWKLLAGRIARGLEKELDVGATLERIERELPDAPYRVKEGINFCLVWIGLHLPAYTSEAIAIGERLGRWDPRPIPKGCTSSYAPDWISAALALRKGEKTEARKAMEAAAKAKAPRGEGKPAVAKAKVASARKKSTAKKPSARTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYW9</accession>
    <name>Q1CYW9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556215.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6277"/>
    <dbReference type="EnsemblBacteria" id="ABF91506">
        <property type="protein sequence ID" value="ABF91506"/>
        <property type="gene ID" value="MXAN_6277"/>
    </dbReference>
    <dbReference type="GeneID" id="41363497"/>
    <dbReference type="KEGG" id="mxa:MXAN_6277"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_9_7"/>
    <dbReference type="OMA" id="GANHERD"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="158"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="41366" checksum="A34FB120E3C9793F" modified="2006-07-11" version="1">MTSPPSPLPPMPTLLAILHIVGCVLLAAVFFAPAGVPTLVHLLKGIVREYSLAMLLPALLTALVAVWISHVDVWRWLRWGTAACALLVGILAVWPAASAWRMARAADTPLRLREYFRPLVGARPLPSHTVRFAVVEGHDLHADVFLPDASATRARPAVLYFHGGGWRGGERGYARAWADFLTARGYALISFDYRLFPPATGLKAPGDVKCGIRWVKDHAATYGIDPDRLVLFGESAGGHLASLAGYTEGDARLPSSCAPGDTSVAAIISFYAPSDLVAYAASAPAPLVGFTGVPQEGHRELYELLSPINHVGPRSPPTLLLHGGADSVVPLDASQAMAARLAQAGVPHTLFTLPYAEHGFDIWDGGFGRQLARAQVGRFLQQHAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ28</accession>
    <name>Q1CZ28_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92605">
        <property type="protein sequence ID" value="ABF92605"/>
        <property type="gene ID" value="MXAN_6214"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6214"/>
    <dbReference type="HOGENOM" id="CLU_3397540_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="31" mass="3475" checksum="53C6ECB5B9AE7027" modified="2006-07-11" version="1">MRPAVLSHATSTREEVDVILQRMGLGPWRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ80</accession>
    <name>Q1CZ80_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556106.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6162"/>
    <dbReference type="EnsemblBacteria" id="ABF90919">
        <property type="protein sequence ID" value="ABF90919"/>
        <property type="gene ID" value="MXAN_6162"/>
    </dbReference>
    <dbReference type="GeneID" id="41363392"/>
    <dbReference type="KEGG" id="mxa:MXAN_6162"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_2_7"/>
    <dbReference type="OMA" id="AMWVYIN"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="288" mass="29622" checksum="4D440F24DD382321" modified="2006-07-11" version="1">MNPTMVFWLFAAAFGASALGGVLGMASGIFIVPILTLFFSIDIHVAIGASIISVIACSCGSAAPLLKKRLTNIRLAIVLETATTLGALTGVFLIGIVSNSFLYGLFSFILALSAKQMLARRREVEVVATSGPNVKSLATVLRLHSSFPDHASGRDVPYQVGHVPISLALMYGAGVISALLGIGSGVLKIPAMDTALRLPIKVSSATSNFMIGVTAAASAGAYFVRGDIDIGIAGPVALGSVVGALVGARLLMRLPAEKIRISFVVILTLLAVQMLLSALGVQFLGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ94</accession>
    <name>Q1CZ94_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87127">
        <property type="protein sequence ID" value="ABF87127"/>
        <property type="gene ID" value="MXAN_6148"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6148"/>
    <dbReference type="HOGENOM" id="CLU_3330553_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="38" mass="3867" checksum="0925A7542EEDA726" modified="2006-07-11" version="1">MFAPQVTATLVTSALPIVPLPLSTVQEAPSGGDWTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZD8</accession>
    <name>Q1CZD8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556049.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6100"/>
    <dbReference type="EnsemblBacteria" id="ABF86031">
        <property type="protein sequence ID" value="ABF86031"/>
        <property type="gene ID" value="MXAN_6100"/>
    </dbReference>
    <dbReference type="GeneID" id="41363334"/>
    <dbReference type="KEGG" id="mxa:MXAN_6100"/>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1658897_0_0_7"/>
    <dbReference type="OMA" id="FTPWHLL"/>
    <dbReference type="OrthoDB" id="1941442at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="16970" checksum="C2B5B1AE0166A291" modified="2006-07-11" version="1">MRCSRYPARRMRFISLVPMLCGLAVVAQAGLNRRFGGQWGLMSAVLLNMVVATVATFAVYFVVRTVPGLWPEAAAGQGRLSGFTPWHLLPGLCGVVIVLGMPLAMSRLGAVQSVLLLMAAQLLTSLVWDAMVEGRPVTFPRVLGSGLAFIGATIAVWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZS9</accession>
    <name>Q1CZS9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555908.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5957"/>
    <dbReference type="EnsemblBacteria" id="ABF92701">
        <property type="protein sequence ID" value="ABF92701"/>
        <property type="gene ID" value="MXAN_5957"/>
    </dbReference>
    <dbReference type="GeneID" id="41363196"/>
    <dbReference type="KEGG" id="mxa:MXAN_5957"/>
    <dbReference type="eggNOG" id="COG0819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098953_0_0_7"/>
    <dbReference type="OMA" id="VHYPTHA"/>
    <dbReference type="OrthoDB" id="1571811at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="26267" checksum="291B6B55FABD5021" modified="2006-07-11" version="1">MGAPSLIRNLKLRQHIAGLKAEWNALDAPYLRALRDGTFAREDFVETQLQFSSAVAHFSRPMAMLASRLPRPHQRLPLVENIFDEHGRGTLAHGHERTFHLLLSRLGVETARVERHVTWPEVRAFNVALTGIAAFEGPLTGLAVFGIIEDLFSGISLDLGRGIVARGWLQHGEVVHYPTHADLDEEHAEGFYRQLDAPYETDAGAAEIEQGLTLGGHLFLGLYDALFRARHRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZV7</accession>
    <name>Q1CZV7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">MXAN_5929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555880.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5929"/>
    <dbReference type="EnsemblBacteria" id="ABF86365">
        <property type="protein sequence ID" value="ABF86365"/>
        <property type="gene ID" value="MXAN_5929"/>
    </dbReference>
    <dbReference type="GeneID" id="41363167"/>
    <dbReference type="KEGG" id="mxa:MXAN_5929"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_0_7"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="30"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="413" mass="44235" checksum="D3048044F7F3F014" modified="2006-07-11" version="1">MNHFAYHKGVLHAEDVPLAAIAESVGTPTYVYSTATLTRHIRVVTEAFGDRPHLICYSVKANSNLAILRLIAERGGGFDIVSGGELARVRHVGGDAGKTVFAGVGKTQEEMEAALAAGILLFNVESAEELEALDAVGRRLGRRAPFALRVNPDVDARTHRYISTGLKTSKFGVPFEEAVALYARAKKMKGLLAAGLDCHIGSQLTQTAPIRAALSKVAGLYSALKEKGHPLAYLDVGGGLGITYLDETPPSPEEYARTVLAAAGATGATLILEPGRALVGNAGVLLTRVLYRKKTPARHFVVVDAGMNDLLRPALYEAHHGLQPLVKRRGKAVEVDVVGPVCESTDVLAKARPLVLPQAGELFAFMSAGAYGMSMSSTYNSRPRPAEVLVDGAAWRVVRERERVEDLWRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZZ5</accession>
    <name>Q1CZZ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pruA</name>
        <name evidence="9" type="ORF">MXAN_5891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555842.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5891"/>
    <dbReference type="EnsemblBacteria" id="ABF89021">
        <property type="protein sequence ID" value="ABF89021"/>
        <property type="gene ID" value="MXAN_5891"/>
    </dbReference>
    <dbReference type="GeneID" id="41363130"/>
    <dbReference type="KEGG" id="mxa:MXAN_5891"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_7"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="59"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="551" mass="60203" checksum="71AED73EBC8EF049" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D039</accession>
    <name>Q1D039_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5847"/>
    <dbReference type="EnsemblBacteria" id="ABF91790">
        <property type="protein sequence ID" value="ABF91790"/>
        <property type="gene ID" value="MXAN_5847"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5847"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057677_0_0_7"/>
    <dbReference type="OMA" id="KKSVYQP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="460" mass="50259" checksum="54120F2C6C89E870" modified="2006-07-11" version="1">MASSAHSGMSFVFKQTCRSGHFGFQAWVPRRTCRPCTASRRLPTRMLRRRAPVPRSASRSMKPAVLIIIGVLTALGGALYLSSRRAAERTEEARPAAQAPVSTRAVRTEITFLYSTEKKAWVEEAAADFQKAHPLIRVNLVGRGSLEAARAILEGSERPTVWSPADSAVLRMLESDWATDATREPLFATEGEAAPRPLVKTPLVFVAWEDRAEVLQRASGGGAVSWKVIHDAVSSDQGWPAVGGQPEWGFVKLGHTDPTRSNSGLQALLLASLEFYGKQSGLTVADLLEPRFQTWLSQLERGTGRFEQSTGTLMADMVRFGPSRYDIAVVYENLAIAQLSQPQGTWGALKVLYPTLTSWSDHPAAVLDGDWVLPRQREAALEWLRYLHSRPVQQRALAFGFRPADASVPLTPPGEASLFPPLAARGLQVDVPDGAAVPDGAVVRNLLTLWTRRVGNARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D048</accession>
    <name>Q1D048_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555789.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5838"/>
    <dbReference type="EnsemblBacteria" id="ABF86301">
        <property type="protein sequence ID" value="ABF86301"/>
        <property type="gene ID" value="MXAN_5838"/>
    </dbReference>
    <dbReference type="GeneID" id="41363076"/>
    <dbReference type="KEGG" id="mxa:MXAN_5838"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_7"/>
    <dbReference type="OMA" id="GSICSAQ"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PTHR43296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="27379" checksum="794ED5DB8BB80B57" modified="2006-07-11" version="1">MADGVFRDGLLAGKVAFISGGSSGINLGIAESFVKAGAKVAINGRNVEKLEAAVKGLQAHGTAMGVAADVRDYAAVEKALQTVREAYGELDVVVCGAAGNFPAPALGMSSNGFKAVMDIDVLGTFNISRAAFEHLRKPGASLINISAPQAYLPMAMQAHVCAAKAGVDMLTRVLAIEWGGSGVRVNAITPGPIDDTEGMRRLAPSDEGRDKLAQALPLQRFGKKQDIAQLALFLASEGSSYITGSIMVCDGGQSLLGGGALMAALGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D061</accession>
    <name>Q1D061_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555776.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89715">
        <property type="protein sequence ID" value="ABF89715"/>
        <property type="gene ID" value="MXAN_5825"/>
    </dbReference>
    <dbReference type="GeneID" id="41363065"/>
    <dbReference type="KEGG" id="mxa:MXAN_5825"/>
    <dbReference type="HOGENOM" id="CLU_986337_0_0_7"/>
    <dbReference type="OMA" id="GMEPAWR"/>
    <dbReference type="OrthoDB" id="1684657at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="34622" checksum="8AE717043A5AC990" modified="2006-07-11" version="1">MQWGMAPVLPWSLLVPVLLLVATCLLGAWGQATVPHAEGDVVATALLDAGRSPRRALRLEQRRGWGQGMVVSVSPEVETVLGVGAGRELRTEYGPEVAVPLYVEWQAGAGRGQARYRVRVGRPEVRAVDDEGMEPAWRLAEELGAVSGRDGAVVLSDRGVPVQAWVQLGPGASAALSSLVRAALSSDWLVTPRLPEEPVGAGARWVVARAQEEGLAVVTYELVELEGARGRVRFLLQSQGAEGPLAPRAEGELRFDLRRPFPERLEVLYTSRAELGTQGARRLEVVRRTRVTLESGSPLAPAHPEMIAAPWISEGEQVRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C0</accession>
    <name>Q1D0C0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555717.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D0C0"/>
    <dbReference type="STRING" id="246197.MXAN_5766"/>
    <dbReference type="EnsemblBacteria" id="ABF89826">
        <property type="protein sequence ID" value="ABF89826"/>
        <property type="gene ID" value="MXAN_5766"/>
    </dbReference>
    <dbReference type="GeneID" id="41363009"/>
    <dbReference type="KEGG" id="mxa:MXAN_5766"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289629_0_0_7"/>
    <dbReference type="OMA" id="IAYKEMG"/>
    <dbReference type="OrthoDB" id="1702458at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1060" mass="113261" checksum="7A83C3978B735B09" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T0</accession>
    <name>MURG_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">MXAN_5604</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0T0"/>
    <dbReference type="SMR" id="Q1D0T0"/>
    <dbReference type="STRING" id="246197.MXAN_5604"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90743">
        <property type="protein sequence ID" value="ABF90743"/>
        <property type="gene ID" value="MXAN_5604"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5604"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_2_1_7"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000315124" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="383" mass="41785" checksum="F7A79EBEC6E3359B" modified="2006-07-11" version="1">MMKVLIAGGGTGGHLFPGIALAEEVVTRHHRNEVVFVGTERGIESRVVPKEGYPLELVKVQGLKGKGFLSLLKALFALPLAFIESFRILARQKPDVVVGVGGYASGPVVMAAWLMGIPTAIQEQNALPGFTNKVLGRIVRVVFIAFEEARAFFPEKKVQLIGNPIRRKLMDNYLRSHVAHERFSVLVFGGSLGARGINQRMTEALDSLGDLKDSLHFVHQTGKNDLESVRKGYADKGFQAEVVEFIDDMSSAYARADLVVCRAGATTLAELTVCKKASILIPFPHATDDHQAVNARALVDAGAALMFRESELTGEKLAQTVRELKSHPERLKSMEKKAGLLGRPEAAKELADVCVDLMVQTWGPNGRERTPIEAEKKAPRSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D133</accession>
    <name>Q1D133_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General secretion pathway protein E, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555455.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5497"/>
    <dbReference type="EnsemblBacteria" id="ABF90396">
        <property type="protein sequence ID" value="ABF90396"/>
        <property type="gene ID" value="MXAN_5497"/>
    </dbReference>
    <dbReference type="GeneID" id="41362751"/>
    <dbReference type="KEGG" id="mxa:MXAN_5497"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946318_0_0_7"/>
    <dbReference type="OMA" id="YGWPPVT"/>
    <dbReference type="OrthoDB" id="1181965at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="31562" checksum="CE0A425BFFEBE628" modified="2006-07-11" version="1">MQTSCLLMETGSRRPLGEILLEQGVLNRAQLRVGLVHHHEVHVPLGRALVREGLCSGADVLRGLAEQFGVDAVDLERTPPDSRRLNHIPARVARQYRVVPLRIDKVLLDQGEREVLHIALPAPVSLDAVDAVRAVSGMPRVEAHIASDAALARALADLYGIETPAEPPMPPSLAPGGPLLLYGWSPVTAVLITRLLARNGLQARTATPLEVLHTGPEDVVLAPLQAMEGLLAGEVHIKGALIVHGSDDESFDRVRELGARGFLASPRDEELLLRAVRRLRPHPGSPDSAPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D185</accession>
    <name>Q1D185_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92164">
        <property type="protein sequence ID" value="ABF92164"/>
        <property type="gene ID" value="MXAN_5445"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5445"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879484_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="33200" checksum="26004A2F46E11B7F" modified="2006-07-11" version="1">MMVVFAHRESASTCLEEETMKRTIWVLMGILIFIPIRTDAQVATRCGDDDKLLPDQVVGRNAWARKCGYIDAARESMLNSMSSYQIFSNGCFKYPCAGRNSNCANFVPASAFSPCVAGLIKIGTCYAEALTLARAEAGQACGPPDPHAQAAGETAQGPGLVKWPVELGVCGDFICGVGEDFLTCPEDCGVAEYCGNGWCGLWENEATCPADCQCGDGICSGDESVDRCPMDCGCPAQCGNGVCNNNETPSTCPADCGTLCGDGVCNGGEDAYTCYLDCGSFCGDGICGLGEDRWSCPSDCGRPCVGKICPVPEIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B2</accession>
    <name>Q1D1B2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555376.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5414"/>
    <dbReference type="EnsemblBacteria" id="ABF92508">
        <property type="protein sequence ID" value="ABF92508"/>
        <property type="gene ID" value="MXAN_5414"/>
    </dbReference>
    <dbReference type="GeneID" id="41362677"/>
    <dbReference type="KEGG" id="mxa:MXAN_5414"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283674_0_0_7"/>
    <dbReference type="OrthoDB" id="1063831at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188256" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1097" mass="115906" checksum="1F87C62058428BA8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I9</accession>
    <name>Q1D1I9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555299.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5334"/>
    <dbReference type="EnsemblBacteria" id="ABF91876">
        <property type="protein sequence ID" value="ABF91876"/>
        <property type="gene ID" value="MXAN_5334"/>
    </dbReference>
    <dbReference type="GeneID" id="41362603"/>
    <dbReference type="KEGG" id="mxa:MXAN_5334"/>
    <dbReference type="HOGENOM" id="CLU_086642_0_0_7"/>
    <dbReference type="OrthoDB" id="1857427at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27702" checksum="D8726D144EA249ED" modified="2006-07-11" version="1">MKLLGRDIPARELIARIEERLRTRGLPTSEEVELPTEGVEPRVEPLTFNLHALEEYADATRALPLHTHRGGVGQVVLLAKWAFRKSCQVFINEALGRQRVFNGHVRDSYAQLSAEVLRLRREVEALRARPVPAVSDAVVPQQERAQRREHEAAPSAVAQPSTAPAPVIDTVLPKPRDTKAHSRPPARPKQPVSAASTEVDATSAPRAPAAGEPVTSKTARAKKAAPSAPAQPSAESSPRRSASGQKKRRNKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L6</accession>
    <name>Q1D1L6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF86040">
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        <property type="gene ID" value="MXAN_5306"/>
    </dbReference>
    <dbReference type="GeneID" id="41362576"/>
    <dbReference type="KEGG" id="mxa:MXAN_5306"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1497607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="20013" checksum="D4B6F073161695FF" modified="2006-07-11" version="1">MPAATIPTIETERLVMKGHSLEDYEECLALWSDPAVVRYISGKPSTREEMWSRLLRYVGHWDLLGFGFWVVREKATGRLVGEVGLGDFHRDMQPPLSAGPEAGWVLAPGFHGKGYATEAVRAALAWADAQLSPERVVCIIAPENAASIRVADKCGFRQTGQGRYKGEPSLMFERLAPVKAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1M7</accession>
    <name>Q1D1M7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5295"/>
    <dbReference type="EnsemblBacteria" id="ABF88940">
        <property type="protein sequence ID" value="ABF88940"/>
        <property type="gene ID" value="MXAN_5295"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852130_0_0_7"/>
    <dbReference type="OMA" id="CTRSGTD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188122" evidence="2">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="326" mass="33037" checksum="9AF7BB60687A1155" modified="2006-07-11" version="1">MTKTSFGRALLPLLLCCLFTTACSSEGPVGPQGPAGPQGPQGPSGGPPGPQGLAGPRGEQGLTGPRGPMGVEGPRGVMGPQGSQGPKGDTGEQGLPGATGAQGPQGPRGDTGPAGPMGPVGESPEICTPGEFFCEGTRLWACTRSGTDAVLNTKCAGGTTTNPTGCFTTACAPGDAACCRTERPTCQWSMSRPISSTGAGYENTNGGFVSPDRSYCYAPSSCLSTDTFTVQMGITGNESVTCGAVFSTLIIRLPRPMTAPGQVFTLPTSRVSLSLFADENARACSNWTGTVTWHSEVPSWSVSVNATCSETGKSHIQLVGSFSGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X4</accession>
    <name>Q1D1X4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555167.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5196"/>
    <dbReference type="EnsemblBacteria" id="ABF92996">
        <property type="protein sequence ID" value="ABF92996"/>
        <property type="gene ID" value="MXAN_5196"/>
    </dbReference>
    <dbReference type="GeneID" id="41362478"/>
    <dbReference type="KEGG" id="mxa:MXAN_5196"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646624_0_0_7"/>
    <dbReference type="OMA" id="FKCVTHQ"/>
    <dbReference type="OrthoDB" id="351393at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="100"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="52981" checksum="5405EE4E156343AD" modified="2006-07-11" version="1">MRWTCPSWRRRCCRTAWKTSWSGPPTRTPGRLTDAAMTPRFRIDASAQLVPEDRHVPSPLAGRSGTYALMATAPDLLVFSRTPAEGGSIPLPRVVLAGDAGGFPLSDLIAFLSQSRWSGVVRVHSPGGERSVTLREGEVRGASSDDPADRLGEVLVRMGYVERAQVEAALREQPPSKVGRSLVEKGLLKSHDLFKCVTHQVSEIFHAIVLCREGTFFLIDQPVEDKSGHIIQLSTQSLLMDSIRKIDEMAHFRKRISHGRLYVTRKRASDGKLEEDEDRVLGLLDGRRTILELGHAARLSEFDVTKVVFRLLEGGFASVTDKPLMVPGPGVPTPIPQPSERTAQAPARAPARPVVTVDPRPVARVFNFIFREIRDEVAKQGMDREFIAAANAALSGQGLSSSPVLEGLAFAPDGSLPENKLIESFERHRAQLGSEPLATFRQALSDMMFFLLFQAGELLESRADEDLARRVKELLSTLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D205</accession>
    <name>Q1D205_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GMC oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5165"/>
    <dbReference type="EnsemblBacteria" id="ABF89743">
        <property type="protein sequence ID" value="ABF89743"/>
        <property type="gene ID" value="MXAN_5165"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5165"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002483_2_0_7"/>
    <dbReference type="OMA" id="WAPRLGM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="4">
        <location>
            <begin position="453"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="540" mass="58899" checksum="ECD4032075C74A25" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D249</accession>
    <name>Q1D249_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional activator TipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tipA</name>
        <name evidence="6" type="ORF">MXAN_5120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555094.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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    <dbReference type="EnsemblBacteria" id="ABF92088">
        <property type="protein sequence ID" value="ABF92088"/>
        <property type="gene ID" value="MXAN_5120"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="HAGHRRY"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="29393" checksum="306B7D0505CBD956" modified="2006-07-11" version="1">MEMALTVSQVARLAKISIRALHHYDELGLLCPSDRSEAGYRLYSQADLQKLQQVLFFKELGFPLEDIRRILGDPTFDLRTALRMQRQLLTERAARLDALVHAVDAALDALEKGTHVDKEAMFEAFGDFDPSKYEEEAKQRWGNTEAYKESARRTARYKKEDWKRIKEEGDVLFQALADLLAAGTSAASAAAMDLAEAHRQYLGRWFYACPPAMHRGLGEMYVADTRFTENIDKARPGLSLFLRDAFAANAERQGAADVPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2I5</accession>
    <name>Q1D2I5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554960.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4982"/>
    <dbReference type="EnsemblBacteria" id="ABF90081">
        <property type="protein sequence ID" value="ABF90081"/>
        <property type="gene ID" value="MXAN_4982"/>
    </dbReference>
    <dbReference type="GeneID" id="41362267"/>
    <dbReference type="KEGG" id="mxa:MXAN_4982"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_1_1_7"/>
    <dbReference type="OMA" id="PGSMGDY"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="BRENDA" id="6.5.1.8">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
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        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="44925" checksum="6611133A46F84BF7" modified="2006-07-11" version="1">MSRINGNYEVLSDEAGRPIKAWTVGVPFEDEAKKQLRNLRGLPFIHKWVSVMPDVHRGYGATVGSVVPTVGAVVPAAVGVDIGCGMIAVRTTLRADQLPDSLRGVRSAIERAVPHGRSDNGGRNDVGAWRVAPARHQKEWARLVEGYDRIVGKHPRIGRGPELSHLGTLGTGNHFIELCLDESDGVWLMLHSGSRGVGNRIGSYFIELAKEDMRRWFINLPDGDLAYLAEGTEHFEDYVFAVSWAQDFAATNRALMLQEAVDALQLSGELPPFELKDAAVNCHHNYIAREHHFGKNCFVTRKGAVRAREGDLGIIPGSMGARSFIVRGKGNADSFHSCSHGAGRVMSREAAKRRFTVEDHVKATAGVECRKDVDVIDETPAAYKPIDAVMAAQADLVEVVHTLKQVVCVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2X3</accession>
    <name>Q1D2X3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554825.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4839"/>
    <dbReference type="EnsemblBacteria" id="ABF88111">
        <property type="protein sequence ID" value="ABF88111"/>
        <property type="gene ID" value="MXAN_4839"/>
    </dbReference>
    <dbReference type="GeneID" id="41362135"/>
    <dbReference type="KEGG" id="mxa:MXAN_4839"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_2_7"/>
    <dbReference type="OMA" id="NERFRQF"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="44"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="239"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="661" mass="72579" checksum="D3A3CDFB231E443B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D341</accession>
    <name>Q1D341_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ORF">MXAN_4770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554757.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4770"/>
    <dbReference type="EnsemblBacteria" id="ABF92383">
        <property type="protein sequence ID" value="ABF92383"/>
        <property type="gene ID" value="MXAN_4770"/>
    </dbReference>
    <dbReference type="GeneID" id="41362069"/>
    <dbReference type="KEGG" id="mxa:MXAN_4770"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="25689" checksum="7BB1231E7F2FFBAD" modified="2006-07-11" version="1">MSGFKDKVVLVTGGSRGIGRACAVAFAKAGASTVVISYAGNEAAAQETVALLQAEGAKAEAIRFDVSDSAACASAVDGIVKGHGRLDVLVNNAGVAVDGLVMRVKDEDWDKQLDTNLKGAFSLIRAVSRPMMKQKGGAIINITSVVGEMGNGGQAAYSASKAGLIGLTKSVARELSSRNIRVNAVSPGFIGTDMTHQINDEMRQKMLEGIPLGRLGNPEEVAGAVLFLAGDAASYITGEVLKVNGGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D343</accession>
    <name>Q1D343_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ORF">MXAN_4768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554755.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4768"/>
    <dbReference type="EnsemblBacteria" id="ABF90877">
        <property type="protein sequence ID" value="ABF90877"/>
        <property type="gene ID" value="MXAN_4768"/>
    </dbReference>
    <dbReference type="GeneID" id="41362067"/>
    <dbReference type="KEGG" id="mxa:MXAN_4768"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_7"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="6"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF90877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="417" mass="43914" checksum="D9AECEAC27099B23" modified="2006-07-11" version="1">MSQRRVVVTGTGLVSALGTGTEKNWQALIAGKSGIAQVTRFDVGKIDTRIAGEVKDFEPEAFIEKREVRRMDLYAQFALAAAQMAVTESGIPIGPDAPHGYIPEKVGVIVGSGIGGISSLEEQHRKGLEKGFDRLSPFFIIQMIINMAPGLISMRYNCKGPNWAPVSACATSAHAIGEAWKSIRLGETDAVIAGGAEAAITPLGLGGFSVMKALSTRNDDPAGASRPFDKDRDGFVMGEGAGILVLEEMEAAKKRGANILAEVVGYGANSDAYHVTQPAPEGEGAARCMRLALQSAGMNPEDVGYINAHGTSTPFNDANETKAIKTVFGDHARKIAVSSTKSMTGHMLGAAGGFEGVVSALALARNILPPTINQTTPDPDCDLDYVPNQAREARVDAVMSNSFGFGGTNAVLVFKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D362</accession>
    <name>Q1D362_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4749"/>
    <dbReference type="EnsemblBacteria" id="ABF87359">
        <property type="protein sequence ID" value="ABF87359"/>
        <property type="gene ID" value="MXAN_4749"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4749"/>
    <dbReference type="eggNOG" id="ENOG5030KHK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464419_0_0_7"/>
    <dbReference type="OMA" id="FTDTRRV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031584">
        <property type="entry name" value="Put_ABC_export"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16962">
        <property type="entry name" value="ABC_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="570" mass="61199" checksum="173BCF8199234A7A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B0</accession>
    <name>Q1D3B0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89472">
        <property type="protein sequence ID" value="ABF89472"/>
        <property type="gene ID" value="MXAN_4697"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4697"/>
    <dbReference type="HOGENOM" id="CLU_976006_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="30907" checksum="44BC418958E4F3C9" modified="2006-07-11" version="1">MRSRWTPASRATTTRPSTRCPCGSRSFGRATPWTTRRARTAVRWERRLASWRSRCARSWSTILTGTTCRPAVPRDKSNAPLPGMSARDAAPERHGPGAQKQAPCLDCDGSRCPERGPPVMSPRSALLLVTSWLVIPGQALAADSTELTPEKVAEIRRDEAQALSEVNAEYGNRKSSEMSTAERREAIDKQKAASASVLEKHGVSGKDFARYEARMSPADNARAKAEEQRLAEAAKAAKQPAPAAAPEEVHVQQGFSDQDPVELEATEGAEPSIDVGVPKDAELPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3E3</accession>
    <name>Q1D3E3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4664"/>
    <dbReference type="EnsemblBacteria" id="ABF86027">
        <property type="protein sequence ID" value="ABF86027"/>
        <property type="gene ID" value="MXAN_4664"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4664"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_7"/>
    <dbReference type="OMA" id="VACHWAE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="350" mass="37707" checksum="530C2AFF4A73A7FB" modified="2006-07-11" version="1">MNSTPLLQVRDLQVHFPVRGGVLGRVRGAVKAVDGVGFDVMRGETLGLVGESGCGKSTLGRAVLRLVEPTAGSVRFDGQELTGLSQRQLRPLRQRMQFVFQDPYASLNPRMTVREILEEPFAIHGLARGPGEREREVAELVDAMGLPREALARYPHEFSGGQRQRIGIARALALRPDLVVADEPISALDVSVQAQIVNLLVDLQQARGLTYVFIAHDLNIVEYVSTRVAVMYLGRIVELAPAASLYRQPRHPYTQALLSAVPVPDPDHARTRLLVPGEPPSPLAPPPGCTFHPRCPHAMERCRRESPPSYALGGGHFAACFLAEADAREAPAAAPSGGSPGVLAQPSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K1</accession>
    <name>Q1D3K1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4604"/>
    <dbReference type="EnsemblBacteria" id="ABF91977">
        <property type="protein sequence ID" value="ABF91977"/>
        <property type="gene ID" value="MXAN_4604"/>
    </dbReference>
    <dbReference type="GeneID" id="41361904"/>
    <dbReference type="KEGG" id="mxa:MXAN_4604"/>
    <dbReference type="eggNOG" id="COG2850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_3_3_7"/>
    <dbReference type="OMA" id="DENPEMT"/>
    <dbReference type="OrthoDB" id="1885303at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="133"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="34424" checksum="249818D6D28762D1" modified="2006-07-11" version="1">MEEHAMKPQAIPRVPLVSREHFIASWEKAGQPVIFTGAVQAWPAFSKWTFEWFRAMHGDIEITVRSALYTRGALPGTSAPLGGARRMKLSTYLDEVGASSSLPLESDLDELADTMLGKRPEDINHLVGPSLLRAVPSLREDVRFPDYAPRWLNRLTESSVWIAPRGTFAQLHRDRAHNLYAQLSGQKRWQLYAPHQARRLQPAPLDWAADLSGVDLEVGAARRMTASGLRPDYDFILEPGDLLFLPVNWWHRVHTVSPSIAFNLWWWDIPSAVRVGPVAARIALGMKLQEAYSSLHRRSPASEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L8</accession>
    <name>Q1D3L8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554582.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4587"/>
    <dbReference type="EnsemblBacteria" id="ABF87313">
        <property type="protein sequence ID" value="ABF87313"/>
        <property type="gene ID" value="MXAN_4587"/>
    </dbReference>
    <dbReference type="GeneID" id="41361887"/>
    <dbReference type="KEGG" id="mxa:MXAN_4587"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007816_0_0_7"/>
    <dbReference type="OMA" id="CAATHYT"/>
    <dbReference type="OrthoDB" id="89840at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1022" mass="106365" checksum="85A00D59C298B16D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M5</accession>
    <name>Q1D3M5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554575.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4580"/>
    <dbReference type="EnsemblBacteria" id="ABF86423">
        <property type="protein sequence ID" value="ABF86423"/>
        <property type="gene ID" value="MXAN_4580"/>
    </dbReference>
    <dbReference type="GeneID" id="41361880"/>
    <dbReference type="KEGG" id="mxa:MXAN_4580"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="QLLSHDW"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="145"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="457" mass="50330" checksum="287D6BEB651E4D1B" modified="2006-07-11" version="1">MSSRARVLVVDDHVEMGQMLKEPLTDDGYKVDIATGGADAIAQLRARVYDAVLCDLRMQDVDGFDVLDAARKLDPDLPVVMMTAFGGVESAVEAMKRGAFHYFTKPFRLDEVRLSLERALEQRRLRTEHRTLKQQAADRGGLGALVGSSTAMRDLYALIERVAWSGAPVLVRGESGSGKELVARALHFEGTRRAGPFVAVNCTALPHALLESELFGHVKGAFTGATTARRGLFVEADGGTLFLDEIGDMAPELQARLLRVLEDGEVRAVGADGSRTVDVRVVAATHQDLETRVKEGRFRADVFYRLNVVTLRLPPLRERREDIPALIEHFLQQAKARNPRSVVQRFSPETLAALGALPWAGNVRELENLVQRLVVLGSTEVVDLPQLRPHLPSDTSQENHPLAAAQRTIVPLRQLETEYIAWAVARCGGNKTKAAELLGIDVSTIHRRERAEGNPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3W4</accession>
    <name>Q1D3W4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88825">
        <property type="protein sequence ID" value="ABF88825"/>
        <property type="gene ID" value="MXAN_4490"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4490"/>
    <dbReference type="HOGENOM" id="CLU_2181029_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="12347" checksum="3CC289F42C04AA6F" modified="2006-07-11" version="1">MEPNDERRGAIITRCRGVERFDEDVRYLLRFFGRQRGGNEALVDRAPLVHVLETRRLMGQRLAEGDRKGAGGHFLGRVLGAPEGPLEQCSLESSDEVLPRIALDFDRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D465</accession>
    <name>Q1D465_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-alanyl-CoA:ammonia lyase</fullName>
            <ecNumber evidence="3">4.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4385"/>
    <dbReference type="EnsemblBacteria" id="ABF85963">
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        <property type="gene ID" value="MXAN_4385"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4385"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047698">
        <property type="term" value="F:beta-alanyl-CoA ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="14250" checksum="396BE66D19782108" modified="2006-07-11" version="1">MSTGTKAIIRLRMSSHDAHYGGNLVDGARMLGLFGDVATELCIRSDGDEGLFRAYDSVEFLAPVYAGDFIEAEGEIISAGNTSRKMRFEARKVIKPRPDVNDSAADVLAEPVVVCRATGTCVVPKDKQRGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4W8</accession>
    <name>Q1D4W8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain, G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4130"/>
    <dbReference type="EnsemblBacteria" id="ABF86842">
        <property type="protein sequence ID" value="ABF86842"/>
        <property type="gene ID" value="MXAN_4130"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4130"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254403_0_0_7"/>
    <dbReference type="OMA" id="GPVWDCA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="535"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="576"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="617"/>
            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="699"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="740"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="781"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="822"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="863"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="904"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="945"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1399" mass="155719" checksum="B4B2B674247BEA4C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D538</accession>
    <name>Q1D538_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">MXAN_4057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4057"/>
    <dbReference type="EnsemblBacteria" id="ABF89951">
        <property type="protein sequence ID" value="ABF89951"/>
        <property type="gene ID" value="MXAN_4057"/>
    </dbReference>
    <dbReference type="GeneID" id="41361387"/>
    <dbReference type="KEGG" id="mxa:MXAN_4057"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_7"/>
    <dbReference type="OMA" id="FHAQWSA"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
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        <property type="entry name" value="tRNA_psdUrid_synth"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="160"/>
            <end position="255"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="281" mass="30772" checksum="6208852C964CD8DC" modified="2006-07-11" version="1">MLPSNSKRIPVALWIWYRGGIFRGFQRQPEGPTVQSALEEALRSVGVPATLMPSGRTDRGVHARMQVVSVRLEAGDSAESLEKRLPPRLPPGLGLCGVRRPTSFHAQWSACGKEYRYRFQLGGAVMPEWAPYALDVSAEPLLQATAVTPERLAALLRSAEGTRDFIAFHEKSSPRKPRTLESATLHALGGGLYEARLRGDGFARYQIRYLVGSALKVAAGLLPEEAWLAALETGQAMEGFKAPAHGLVLWEVRYPPQVDPFTAGERLHPPGLPLEPPFHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5G2</accession>
    <name>Q1D5G2_MYXXD</name>
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        <submittedName>
            <fullName evidence="5">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3931"/>
    <dbReference type="EnsemblBacteria" id="ABF89350">
        <property type="protein sequence ID" value="ABF89350"/>
        <property type="gene ID" value="MXAN_3931"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3931"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965339_0_0_7"/>
    <dbReference type="OMA" id="EWILRAH"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="4">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="32627" checksum="159DEF42BE6C63B3" modified="2006-07-11" version="1">MTRSVGIVIHKVVPSFRLAVARFQYNMASKMYSHQGYKFINCGYADMEGDHKAVDFNRPENVYVLWESLYQRVVGQAELSGREVLEVGCGRGGGSEYLMTRLKPRSLTAVDLSDVAIARCKENYRLDGLSFQVGNACALPFEDRRFDVVVNIESSHCYPSQLTFFEEVKRVLKPGGAFCFADITESAEHTARINEEFKALGFTVVHHENITANVVKALNVVKETPQFTEAFERWESPNKKGNMKVPLMVINGTLKDLNSGKEYQRWVVRREEATERPVAGEQARAAAAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U1</accession>
    <name>Q1D5U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmgB</name>
        <name evidence="5" type="ORF">MXAN_3800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.157" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3800"/>
    <dbReference type="EnsemblBacteria" id="ABF89759">
        <property type="protein sequence ID" value="ABF89759"/>
        <property type="gene ID" value="MXAN_3800"/>
    </dbReference>
    <dbReference type="GeneID" id="41361131"/>
    <dbReference type="KEGG" id="mxa:MXAN_3800"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_7"/>
    <dbReference type="OMA" id="FYDYSES"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044248">
        <property type="term" value="P:cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="186"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30237" checksum="665264AD470C053A" modified="2006-07-11" version="1">MATEHIVVVGAGQMGAGIAQVALVAGLRVTLADVSEAGLAKGADRIRAGLKKLVEKGKLDAAKQQAAEANLLTVTKVTDAKDVDFAVEAVTESEGLKRGIFLDLDEIVRPGGVLATNTSSIPITRIAAYTKRPESVIGMHFMNPVPVMQLVEIIRGAATSDETYATTRVLAEKMGKTTVVSKDYPGFIVNRILIPMLNEACFAVMEGLGSVEDIDTAMKLGTNQPMGPLQLADFIGLDTVLYIAEVLHKGLGDPKYRPSPLLRQYVEAGWYGKKNGRGFYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z9</accession>
    <name>Q1D5Z9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553755.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3740"/>
    <dbReference type="EnsemblBacteria" id="ABF90747">
        <property type="protein sequence ID" value="ABF90747"/>
        <property type="gene ID" value="MXAN_3740"/>
    </dbReference>
    <dbReference type="GeneID" id="41361073"/>
    <dbReference type="KEGG" id="mxa:MXAN_3740"/>
    <dbReference type="HOGENOM" id="CLU_1958257_0_0_7"/>
    <dbReference type="OMA" id="VWRQVQK"/>
    <dbReference type="OrthoDB" id="1840798at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16957" checksum="8E64B5997C1D34E6" modified="2006-07-11" version="1">MTGSENARYAIVDFSRSVTDLAADSKQSEVVKQINEAFQAAQDRLAQLREAVERNTDLARANARTTVLKDQKEKALKELGEAVWRQVQKGRLDLPAGFGVALKAVEAAEQAVEAHARELTDLLREGEEVAQRLNEQKNAPRPQRVLVPGAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D644</accession>
    <name>Q1D644_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3692"/>
    <dbReference type="EnsemblBacteria" id="ABF89905">
        <property type="protein sequence ID" value="ABF89905"/>
        <property type="gene ID" value="MXAN_3692"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3692"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="RNGSYCE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="65"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="155"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="476" mass="52486" checksum="C94E38F8865B85BE" modified="2006-07-11" version="1">MRRPTPQSGCDIVRAVASLGDEDGDDELVRTDALPAIRVQRVRTRLVVLSGPDAGRDWPLMPGRYRVGSGRDADILLSDRAVSRQHLILDVNESGVRAVDPGSRNGSYCEGMRFQELEVRTGAVLKLGTSELKLMPESERPRARPLSARSAFGSLVGNSRRMRELFTLLERLSAGESDVLIQGETGTGKELCAEAIHTHSPRARGPFVIADLAGIAPSLLESELFGHVKGAFTGAHSDRAGAFERAHGGTLFLDEVGELPLEVQPRLLRALERRQVKRVGSNDYRTFDVRVVAATHQDLEGSVQAGRFRGDLFHRLAVLRVSLPPLRERLEDVPLLVDTVLQRMGRPPSALSDQTRALLAQYPWPGNVRELRNVVDRVVNLGDEALPDIPDLPSPPEDPTTLPPPSDDPESTRPISLDLPFKEAKDRIIEGFERDYLRALIDRCEGNVSRAAREAGIDRVYLRKLLRKHGLDTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6U3</accession>
    <name>Q1D6U3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553466.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89245">
        <property type="protein sequence ID" value="ABF89245"/>
        <property type="gene ID" value="MXAN_3433"/>
    </dbReference>
    <dbReference type="GeneID" id="41360781"/>
    <dbReference type="KEGG" id="mxa:MXAN_3433"/>
    <dbReference type="eggNOG" id="COG3911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114480_0_0_7"/>
    <dbReference type="OMA" id="TPPWPEI"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19910" checksum="4CD54F5F9AF584B4" modified="2006-07-11" version="1">MTVHLHVITGGPGSGKSSLIEALAVEGLAHMPEAGRAIIQQQVAIGGHALPWADRTAFAELMLGWEMRTHKEACELRRPVILDRGVPDVIGYLRVCGLPVPPHLWKAAELFRYNRRVFIAPHWPEIFAQDAERKQAPDEAKATYRSMVEVYTSLGYELLPLPLASLPERVRFVRSNIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D768</accession>
    <name>RL16_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">MXAN_3306</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002633601.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D768"/>
    <dbReference type="SMR" id="Q1D768"/>
    <dbReference type="STRING" id="246197.MXAN_3306"/>
    <dbReference type="EnsemblBacteria" id="ABF88224">
        <property type="protein sequence ID" value="ABF88224"/>
        <property type="gene ID" value="MXAN_3306"/>
    </dbReference>
    <dbReference type="GeneID" id="41360659"/>
    <dbReference type="KEGG" id="mxa:MXAN_3306"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_7"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251648" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="139" mass="15511" checksum="AB3CAEDBB7688D8C" modified="2006-07-11" version="1">MLQPARTKYRKMHKGRMPGSAHRGSDMTYGEYGLMSLQPGWITSRQIEAARIAMTRHVKRGGKIWIRIFPDKPITKKPAETRMGTGKGGVEYYVAVVKPGRILYEMEGMTPEVATGALKLAQAKLPVLTKIVKRADLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D799</accession>
    <name>Q1D799_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553320.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3275"/>
    <dbReference type="EnsemblBacteria" id="ABF85999">
        <property type="protein sequence ID" value="ABF85999"/>
        <property type="gene ID" value="MXAN_3275"/>
    </dbReference>
    <dbReference type="GeneID" id="41360627"/>
    <dbReference type="KEGG" id="mxa:MXAN_3275"/>
    <dbReference type="eggNOG" id="ENOG502Z93N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570643_0_0_7"/>
    <dbReference type="OMA" id="INHFNQA"/>
    <dbReference type="OrthoDB" id="434836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="55283" checksum="185F1AFBB0B79D27" modified="2006-07-11" version="1">MAALAEARVEQVAREDLVMFVNACFSCTGQREFYGDARGQSVSIEFLHQYILGNYRRLYARTLAAGINHFNQAQIILNLLASGSPADARDKAEEGALIAAALRALPPQRAFRVLESLRGRRINNRRARAIARDYVHGRANLAFDAVKYRSKLRAAVSHGHLKLEGELGPFLFRGWKKRFFTQPLLETFRRAHYTHEALYELPYTVAEGLAVKHGISREVFLRRIEPRLTAAERLRLQESAARERGTPPPVDLGRASLTKLALYVLALSLEVRRERHAELHAALEQAAARVLRRAPSPLQRVAAILDNSYSSSGSLEKRRRPLGVALATHYLLSAAAREYRAWWTCPVEEPLLVSARGQTDIATPLLDALAWGADLVVIVSDGYDNDPPKAVAELTRVFRSKLDPERHTALVHVNPVFDSEGYAPRSFGAAVPTVGVRDAEDVPTVLGFARFAEGVASLSELEAYLASRVGAMLQRDAGDRRGDDEGRRQEAPSAEEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A0</accession>
    <name>Q1D7A0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553319.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3274"/>
    <dbReference type="EnsemblBacteria" id="ABF88448">
        <property type="protein sequence ID" value="ABF88448"/>
        <property type="gene ID" value="MXAN_3274"/>
    </dbReference>
    <dbReference type="GeneID" id="41360626"/>
    <dbReference type="KEGG" id="mxa:MXAN_3274"/>
    <dbReference type="HOGENOM" id="CLU_161986_0_0_7"/>
    <dbReference type="OMA" id="CRGPLGC"/>
    <dbReference type="OrthoDB" id="1819455at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187955" evidence="1">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="12968" checksum="908512F26BA89B43" modified="2006-07-11" version="1">MPMNRSLLALVPLVGSLLLAGCGPSAGGDCDGGGFVCQERVLALECRGGKWRELPCRGPLGCRETSEAVRCDTSNNVAGDACASSAEGTGLCRADGQAVLECRQGVLTETATCSACTVENSQVTCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H0</accession>
    <name>Q1D7H0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3202"/>
    <dbReference type="EnsemblBacteria" id="ABF89218">
        <property type="protein sequence ID" value="ABF89218"/>
        <property type="gene ID" value="MXAN_3202"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3202"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="YGAFAHE"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="59494" checksum="95BF6B582A2E4239" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7M8</accession>
    <name>Q1D7M8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553192.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3142"/>
    <dbReference type="EnsemblBacteria" id="ABF91164">
        <property type="protein sequence ID" value="ABF91164"/>
        <property type="gene ID" value="MXAN_3142"/>
    </dbReference>
    <dbReference type="GeneID" id="41360501"/>
    <dbReference type="KEGG" id="mxa:MXAN_3142"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047522_1_0_7"/>
    <dbReference type="OMA" id="HCERELA"/>
    <dbReference type="OrthoDB" id="1622875at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="278"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="42596" checksum="3BBF186512CCA8A7" modified="2006-07-11" version="1">MSSMVQACRPPAARALTDGDRTACWPRQRAISVPFVAQPPLSSSSEPSLSARMARQALRLAATLGLPVEALCREAGFRMEDLDDPELRIPYAALDGLLERAAELSGDANLGLHIARVDVVDLDDPATFVVLTCATLREAMERGCRYQRVWGDGERFLMEETERGVRMRFTPVGAPRPAHRHLVDAALVQFATGVRAFTGVDVRPLVVRFTHTAPADLREHEALFGCPLEFGAPFNAIEFSHEDAQRPFIHGNALLNAMFQRQAQRALERLPDVSTTTERVRQQVRRELAGGDFSFVAVARALRQPPRTLQRRLAGEGQSYAAIVEALRRELSESYLQRRMSIAEVSFLLGYADPVAFHRAFKRWWGVSPEGFRRERLQAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8C7</accession>
    <name>Q1D8C7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552946.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2885"/>
    <dbReference type="EnsemblBacteria" id="ABF86473">
        <property type="protein sequence ID" value="ABF86473"/>
        <property type="gene ID" value="MXAN_2885"/>
    </dbReference>
    <dbReference type="GeneID" id="41360254"/>
    <dbReference type="KEGG" id="mxa:MXAN_2885"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064453_0_0_7"/>
    <dbReference type="OMA" id="DNATPNY"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="41940" checksum="95C6EAD450A1BB6D" modified="2006-07-11" version="1">MIEIGTIEAFERHLSAGVGFANVIIQGLDLRRYTQELASAKLVGAVFLGCELEKDALKATVEHGAMVFPPISGVPYQPYRGALYTPEELYAGFDPAQPESYADTPDARIYAHWAANGRGSPPTLLETLAQRLHDHSVTEAMQGLLYRSGGVRKVVAIMGGHSMKRGQPDYRAVASLARELARRGFFMVSGGGPGAMEATHVGVWFARRTEAELDAGLALLAQAPSYTDREWLSRAFDVRRAFPLGEDDLPYCTSLGIPTWHYGHEPPNPFATHIAKYFANSVREDGLLTVAKGGIIYSPGSAGTIQEVFQDACQNHYNSVGVISPMIFLGTEFWTRTRPVYPLVHQLAQGYDYARYLMLTDSQEEVVWALEAFDREAHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R1</accession>
    <name>Q1D8R1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2745"/>
    <dbReference type="EnsemblBacteria" id="ABF91230">
        <property type="protein sequence ID" value="ABF91230"/>
        <property type="gene ID" value="MXAN_2745"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2745"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089959_0_0_7"/>
    <dbReference type="OMA" id="MALTYEP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="24803" checksum="6F94E1AB5644E98A" modified="2006-07-11" version="1">MAPIVPSVAPAAATAVTPPPAPAASTDLGLDIQQLADLESRCAKLDQLDYFEVLMLERTATPADIKRAFYRESRTYHPDRFFHMDSKELKERINDLYKRVTEAYYVLRDDTKRKKYVVDVTGPERAQKLRFTEASEAETKAAAKKEQEEQIGTHPKGRQFFQQAQKDADAGNWSAAERNLKMALTYEPSNARYKERLAEVQKQSQDEARDKGGSFKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8W2</accession>
    <name>Q1D8W2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552762.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D8W2"/>
    <dbReference type="STRING" id="246197.MXAN_2694"/>
    <dbReference type="EnsemblBacteria" id="ABF88673">
        <property type="protein sequence ID" value="ABF88673"/>
        <property type="gene ID" value="MXAN_2694"/>
    </dbReference>
    <dbReference type="GeneID" id="41360072"/>
    <dbReference type="KEGG" id="mxa:MXAN_2694"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786761_0_0_7"/>
    <dbReference type="OMA" id="FYNATRK"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="372" mass="40148" checksum="46B297E02E718D8F" modified="2006-07-11" version="1">MSSVNLMAREVAAKIVFYGPGLSGKTTSLRKIYETVRPAHRGEMMSIATEGDRTLFFDFLPVKVERVGDCSVRLALYTVPGQVFYNATRKLVLQGADGVVFVADSQPEAMDANRESLANLEENLFEHGIRLDRFPLVMQWNKRDLDGVLPVEVLRKELNPRGVPELETSAANGRGVLDTLKAITRLVIKDLRAKRIVPPPRPTASAQPAGLEAQLTQHLQHRQQPGAVASQPVQAGGPVPRVAPVAVMPPPRVEPTPIPAPQPGPKLLGAASALAPGDMFDHARAAEAAFMTGDYATCVTACTDAIRRALAFAGEGSLGQQAFLLRVDGADLLRLQGLGTQQHLRVDDAAFSLYVMMQVFIRLNAVGLPNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Z5</accession>
    <name>Q1D8Z5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2659"/>
    <dbReference type="EnsemblBacteria" id="ABF91659">
        <property type="protein sequence ID" value="ABF91659"/>
        <property type="gene ID" value="MXAN_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2659"/>
    <dbReference type="eggNOG" id="ENOG50319B7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536264_0_0_7"/>
    <dbReference type="OMA" id="YAYRISW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188370" evidence="1">
        <location>
            <begin position="22"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="511" mass="55631" checksum="9DAF9F15320B5F36" modified="2006-07-11" version="1">MKTLQKLALTGLISLSAPAWASDFVDTRLSFVFADDNVLAGSGETTPNSPDARFGAGNQNTQFYDNFNTRFSGFESLSNVVLYKRAPAFFEGLTTEAALTLLVLERPSGGVDIRDNSSYIRLNYQPPGWSEKEGISLVGFPVSADRFRLGYAYRISWGGSGVFTTRAATNGVPGGKLQITRDNWYAYVGGKTALMQNELIREEETKYGLMAGAGWDILETLRVEAGGGYFQKGLVPGLATLGVEAPVNAAGVSGQIVYHVGVPVGTSVDFRLYKNDPDIYQRFFAPEQYPGGLSYTVSLEGSYLSQTLEKPNDFGATKPQGATAVALQARAKYDLLRVSLLGLYRSLSFIQFEVPGFPPFQDFPEGTELKPEMFLAVGADYHLPKLHFTPGFIIGVQQPASFRSPTPVLGGNNPPENLIGTRTVVVRDVNQLSILPETCGRGGAACKAEPIYSAKATFRWDLSDSVAAVGEVYYTYDTNRTTFRDDVTGVAQPSFERPHALGFNTMLQARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D945</accession>
    <name>Q1D945_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">MXAN_2609</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552679.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2609"/>
    <dbReference type="EnsemblBacteria" id="ABF87466">
        <property type="protein sequence ID" value="ABF87466"/>
        <property type="gene ID" value="MXAN_2609"/>
    </dbReference>
    <dbReference type="GeneID" id="41359986"/>
    <dbReference type="KEGG" id="mxa:MXAN_2609"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_7"/>
    <dbReference type="OMA" id="GSMYILD"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="261"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="607"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="643"/>
            <end position="650"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF87466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="966" mass="105822" checksum="763542053D729383" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I9</accession>
    <name>Q1D9I9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552536.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2464"/>
    <dbReference type="EnsemblBacteria" id="ABF91830">
        <property type="protein sequence ID" value="ABF91830"/>
        <property type="gene ID" value="MXAN_2464"/>
    </dbReference>
    <dbReference type="GeneID" id="41359847"/>
    <dbReference type="KEGG" id="mxa:MXAN_2464"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789653_0_0_7"/>
    <dbReference type="OMA" id="SGTHVED"/>
    <dbReference type="OrthoDB" id="268932at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="38745" checksum="6457A31548086D63" modified="2006-07-11" version="1">MSVRLTVTQRSEAGAAQSTEFVLDDAVITLGRDKACQVVLAQQAVSRNHARICQDGPLFFVEDLGSSYGTQINGKPVPKGEKRLLRNGDVIAIATFDVRFERVMDLNPESGGEKTSFIARGMVKDAMRGLAGGGEERYLRFMNGPREGERIELGDAKEVILGRDEKDADIILKDDLVSRKHAKVRRDWSGTHVEDLGSRNGIKVNKKRVNRRQLKDGDELEVGATRFLYVDPTEPAEEPVQLAAEVKAPPPPSPRRPRPEPKPVEPPPEEEPAPPPEEPAPAPEEPPAEEPAPPPEEQVSEEPPPPVSAEYPMPDEPAQPSAMAALKDKGKLVPLVVMSVVGLVFLVLMIAVLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA87</accession>
    <name>Q1DA87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552291.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89830">
        <property type="protein sequence ID" value="ABF89830"/>
        <property type="gene ID" value="MXAN_2215"/>
    </dbReference>
    <dbReference type="GeneID" id="41359603"/>
    <dbReference type="KEGG" id="mxa:MXAN_2215"/>
    <dbReference type="eggNOG" id="ENOG5031GSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562381_0_0_7"/>
    <dbReference type="OMA" id="NEQSGRH"/>
    <dbReference type="OrthoDB" id="588009at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="505" mass="53500" checksum="45955C79CB65DADA" modified="2006-07-11" version="1">MARSLLMRGHCQPTPKEQHPMQNSRSWLAAVAAVAFVTTGCDSDEAPDAKKVADIAASRSAETLRGVSSSMKTVSGLSTLNGLDDAMALFGAGFEGVPLPGLQVGDEGEALSTLFDADEVDAQADELERFLRERVFTEANVESTEDNATVFRLKGEQICTDGRAPADADCVRFVDDAQLRVRATNLGDDSLELELLIGAKRAEPLALRFLPKAVSLVVDLGGLKGAVEQLDAESAGFLPKVMVGQVELKVTKEGESHWIVSASILDALRLELALEGSTFAFSSARAVPLVAFEADGQAKRARFSLDLNTTEVRLPYTGLAPALRGKDWTVSLAGISYSVEATENQTDFVVKNLGLGDAQTHLSLGNDKLFALDLNEQSGRHFDVTLTRGADGAPLLKVQPEFDLVTRFYLAPLKADPASEIPAAYEDATYRLRLSGGAGGPSLRAAPANSATGFKGGLQVVTGELLLSANDSQVVVAQGQCLVGAEPASENDASLLSYLRQGSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAJ2</accession>
    <name>Q1DAJ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase orfB, IS3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2103"/>
    <dbReference type="EnsemblBacteria" id="ABF92687">
        <property type="protein sequence ID" value="ABF92687"/>
        <property type="gene ID" value="MXAN_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2103"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093676_1_1_7"/>
    <dbReference type="OMA" id="DARAWVM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="17241" checksum="99B9139FA98413F2" modified="2006-07-11" version="1">MLHSDNGGPMKGATLLATLQWLGVTPSFSRPRVSDDNAFSEALFRTLKYRPTFPQRPFASAEDARAWVMRFVAWYNSEHRHSAIHFVTPDDRHSGHEATLLARRDQVYQRARVRHPERWRGGTRNWTPAGPVRLGPSPNLTPAVQEMKRIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT4</accession>
    <name>RNPH_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease PH</fullName>
            <shortName evidence="1">RNase PH</shortName>
            <ecNumber evidence="1">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rph</name>
        <name type="ordered locus">MXAN_2004</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552094.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAT4"/>
    <dbReference type="SMR" id="Q1DAT4"/>
    <dbReference type="STRING" id="246197.MXAN_2004"/>
    <dbReference type="EnsemblBacteria" id="ABF87690">
        <property type="protein sequence ID" value="ABF87690"/>
        <property type="gene ID" value="MXAN_2004"/>
    </dbReference>
    <dbReference type="GeneID" id="41359414"/>
    <dbReference type="KEGG" id="mxa:MXAN_2004"/>
    <dbReference type="eggNOG" id="COG0689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_7"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000024837" description="Ribonuclease PH">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <sequence length="237" mass="25265" checksum="C25670C9013C04CD" modified="2006-07-11" version="1">MRSFQRGALDLRPVVLTPGVSRYAEGSVQVEFGHTKVLVTCSTEERVPPHLMGKGSGWVTAEYGMLPRATHSRNQRESAKGKQTGRTMEIQRLIGRSLRAAVDLSTLGPRTLTLDCDVLQADGGTRTASITGAYVALVLALRSLQKAGTISKLPKLTPLAAVSVGIVKGEVRVDLDYDEDSTADVDLNLVATADGRMVELQGTAEHQLFDRKALDAMVDGGLAAIQKLTAAQAQVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAX4</accession>
    <name>Q1DAX4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1964"/>
    <dbReference type="EnsemblBacteria" id="ABF86451">
        <property type="protein sequence ID" value="ABF86451"/>
        <property type="gene ID" value="MXAN_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1964"/>
    <dbReference type="HOGENOM" id="CLU_154543_0_0_7"/>
    <dbReference type="OMA" id="CLPRTEY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="14852" checksum="10B2C86F7E34701C" modified="2006-07-11" version="1">MVPRPGHPHVVIAHERTSAGASAPRQKGRQTMAYGLAEDPALSITPHLDAVEYPVEREQLAAAAADAGAPPDVINLFKCLPRREYATREAVQRDLSEASRRSALGGSRDDDDGVNRDRRNIGRDAVEDAPDGQTRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB18</accession>
    <name>Q1DB18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552011.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1911"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="EnsemblBacteria" id="ABF86202">
        <property type="protein sequence ID" value="ABF86202"/>
        <property type="gene ID" value="MXAN_1911"/>
    </dbReference>
    <dbReference type="GeneID" id="41359325"/>
    <dbReference type="KEGG" id="mxa:MXAN_1911"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_1_7"/>
    <dbReference type="OMA" id="AGWAVRY"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="393" mass="41466" checksum="B896EC0C68C3B469" modified="2006-07-11" version="1">MSGGTHPIAILQKVLDDACELGVFPSAQAVVLHRGAQVFGGVAGKVSGDTRFDLASLTKVISTTSLFLRLWTEGKVGPETLVSRYFPGTPVGDAGVTVADLLYHRSGLPPFVPFFAQALTAHPELLDADCPSALRARVRDEVIQAAAATPLAAEPQTLAAYSDVGFILLGEILSRAAGAPLDTLFSRHVAEPLGLSARFHRLTDFPADAMPAPTGATRPREPAPGQETLWKDVPTQPTRLGEVDDDNAWVMDGVAGHAGLFGTAVDVARFGQAVLDGCAGGAIIAPGPLWHRALATDPKVQASTRSMGFDSPSEGVSSAGHYIGDTPPGAVGHLGFTGTSLWVDLRRSLVVALVTNRVANGRQETRIRDFRPLFHDFVVEALELTETKQGHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB74</accession>
    <name>Q1DB74_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551955.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1853"/>
    <dbReference type="EnsemblBacteria" id="ABF90512">
        <property type="protein sequence ID" value="ABF90512"/>
        <property type="gene ID" value="MXAN_1853"/>
    </dbReference>
    <dbReference type="GeneID" id="41359270"/>
    <dbReference type="KEGG" id="mxa:MXAN_1853"/>
    <dbReference type="eggNOG" id="COG3497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_533072_0_0_7"/>
    <dbReference type="OMA" id="RTVHYED"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="511" mass="52334" checksum="AE05FC922E93FB21" modified="2006-07-11" version="1">MSRALLSSKIVVEEEEPRVRGIPSAPTSVAGAVGLAERGPIGQAVLCTSFEEYQATFGGFTPDSDLALAAMGFFEQGGSHLWAVRTVHYEDVSNPESHTATRAAAALTTGGGPTPAVVRGTLRPPFTLADGQRLEVSVNGAEAVDVIFSGAAASVSAGRPGPYALTAGQALRVRVDAGRDVFIPFLEESFGDIAQATAQEVAAVLNAGLVGGRALVEDGVLRIASDTQGAASRLEVDDEVAGDVFGFPGGPQVGSGNVQSLRAVELAEVRALVEAAVAGVRVAPSSLGTLQVRTQSTGPGASLRVQGDAGPGLGLDALLHTGDASGAIDVLHLEAKDAGAYANRIEVEVRPATAGAPDTFDVLVLEDGAYRESFPNLSSAEDDARYAERVLNDERTGSSYVRAFMVQPGALPDEQTVALTGGTDGLVGLNDTDFIGSEAGGSGLLRARRSAGPHASPGPRPGHASRAQRHGALLRGGEKRIGVRHSRLARGLQGGGHGFLRLAGGGSRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ9</accession>
    <name>Q1DBJ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1723"/>
    <dbReference type="EnsemblBacteria" id="ABF90038">
        <property type="protein sequence ID" value="ABF90038"/>
        <property type="gene ID" value="MXAN_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1723"/>
    <dbReference type="HOGENOM" id="CLU_2826618_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="66" mass="7658" checksum="6024D4C7B4E32111" modified="2006-07-11" version="1">MQSVVVRVTNSASARMFLTNALVSRCLNGEPRRKTARYWQHPRLEREPTPQWKRMRGDAFAEKAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL6</accession>
    <name>Q1DBL6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF88038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88038">
        <property type="protein sequence ID" value="ABF88038"/>
        <property type="gene ID" value="MXAN_1706"/>
    </dbReference>
    <dbReference type="GeneID" id="41359144"/>
    <dbReference type="KEGG" id="mxa:MXAN_1706"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="NIARCRH"/>
    <dbReference type="OrthoDB" id="1977684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188460" evidence="3">
        <location>
            <begin position="23"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="440" mass="44903" checksum="4D18111F60659C0C" modified="2006-07-11" version="1">MAMKPLRRSTVLGLLVLSVHLAACLDVDEAVDQFCNSKPGACLDGASDAGPDGNGSLDGGNDGGGPHGEDGGPHGGGDGGSDAGTDGGPPDGGREPPGWKSVAPMQTRRTGHTATELRNGRVLVVGGSSSGNTPTNTTELYTVSSNSWSPGPDLATARMDHTATLLPNGNVLVVGGRGPGGGALNSAEIYDAEANEWAPANPIPLGARASHAAVLLPSGKVLVAGGGNSHLDGLNTAALYHPDTDSWTDAGSLNVKRNVLTLTLLEAGVVVAIGGFNAAGAETTAEVYDSNQPEAGWRLLLAQMEHGRHGHASTRLPSGRILVTGSLEGSPGRVLRAAELFQLSSTSWTPQAEMMEARFFHTATALPSGEVLIAGGYSSPYAMPRASAEIFRRDGSSEFIAPMSSARVNHTATWLESGSVLIIGGIDGGAVLNTAERYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL7</accession>
    <name>Q1DBL7_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF90619">
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        <property type="gene ID" value="MXAN_1705"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_489860_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="556" mass="59625" checksum="06098791661DD951" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX5</accession>
    <name>Q1DBX5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_1596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1596"/>
    <dbReference type="EnsemblBacteria" id="ABF88799">
        <property type="protein sequence ID" value="ABF88799"/>
        <property type="gene ID" value="MXAN_1596"/>
    </dbReference>
    <dbReference type="GeneID" id="41359041"/>
    <dbReference type="KEGG" id="mxa:MXAN_1596"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="EIHYGEP"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="105"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="34653" checksum="131EAE8E08F79B46" modified="2006-07-11" version="1">MCHEWGAGGRAGEYRSTPGGCPTNPVWKAAGPGTSGWYGAPVALTDSLEARVDRLELPFNEYGVDPYGISKSHVKHALRVFGAIYRYYFRVRCYGVEHIPPRGRGMLVGNHSGGVAVDGAMVLTSTMLEMDPPRLAQGMVERFLHNFPVSSLWASRTGQFIGLPEHAKRLLEDDRLLMIFPEGARGTAKLYNERYSLVDFGTGFVRLALQTRSPIIPFAFLGGGSAVPTVFNAYTLGKLLGVPYVPLTPYLLPLPLPVQLEIHYGEPLVFHGTGDEEDHVIEGYVEKVKQRIAGLIERGRAQRHSRRIGRNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBY1</accession>
    <name>Q1DBY1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative para-aminobenzoate synthase, component I</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_1590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1590"/>
    <dbReference type="EnsemblBacteria" id="ABF88353">
        <property type="protein sequence ID" value="ABF88353"/>
        <property type="gene ID" value="MXAN_1590"/>
    </dbReference>
    <dbReference type="GeneID" id="41359035"/>
    <dbReference type="KEGG" id="mxa:MXAN_1590"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_7"/>
    <dbReference type="OMA" id="MHMVSDV"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="218"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="53731" checksum="16DAA8307C9B27C9" modified="2006-07-11" version="1">MSRPPSPTRFPDRTSFETFVAQGYNQVPVVRRLPLGALRPVDLLRALPAESRFLLESTRVSAEGRYSFLGAKPFLRFTAKEGQCFIDGALQQGTPQEVLRSLLRRWRGVRHPGMPLFCGGAVGFFGYEAAHCFESLPRHPRDDLHLPEIDLSFIDTFLTVDHHEGQLLLVATGSDWEDCERRLDALEVHVRTATPTAPRVPPAMDGPTSAYRSNFTLDAYLDAVERVREYIRAGDTYQVNLSQRLEVDFPGEPLALYETLSAINPVHFASYLEGDGFHVVSASPERLVRVENGRATTRPIAGTRRRGTPEEEARFVHELRTNEKERAEHAMLVDLERNDLGRVCTYGSVEVTKLMDIVEYAHVLHIESEVVGQLAPGVEPLDVVGALFPGGTITGVPKIRTMQIITELEPHARGLYTGSLGYLSFTGDLDLNIVIRTLVVKDGQAYAQVGGGIVHDSQPRQEYKETLNKARSQLLALASVGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBY2</accession>
    <name>Q1DBY2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative para-aminobenzoate synthase, glutamine amidotransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551700.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1589"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="ABF89768">
        <property type="protein sequence ID" value="ABF89768"/>
        <property type="gene ID" value="MXAN_1589"/>
    </dbReference>
    <dbReference type="GeneID" id="41359034"/>
    <dbReference type="KEGG" id="mxa:MXAN_1589"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_7"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20214" checksum="92F13FEB53C70BBD" modified="2006-07-11" version="1">MILVIDNFDSFTFNLVQALGAQGAELKVVRNDAITVAQVEALRPDHILISPGPCTPHEAGVSMDVIRALGGRVPVLGVCLGHQCLGQVFGAKVVRAPVPVHGKTATIEHSGQGVFRGLPAPFTAARYHSLVVDAESLPACLEVTAWQDGLIMGLKHRELPRLEGVQFHPESFLTPQGPQLLANFLEPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC51</accession>
    <name>Q1DC51_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551631.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1520"/>
    <dbReference type="EnsemblBacteria" id="ABF90494">
        <property type="protein sequence ID" value="ABF90494"/>
        <property type="gene ID" value="MXAN_1520"/>
    </dbReference>
    <dbReference type="GeneID" id="41358966"/>
    <dbReference type="KEGG" id="mxa:MXAN_1520"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_7"/>
    <dbReference type="OMA" id="RIWDSKV"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="26596" checksum="FDA2C7B9619098F9" modified="2006-07-11" version="1">MDLELGGKVVLVTGGSEGLGAAVARRLVREGAKVALCARGAERLEATAAALRAEGGDVLTVQADVSRAWEVEHFVDAAHARFGRIDGLVNNAGTAAGRPFASVSDAEWEADLQLKVFAAIRASRQALPFLKESGSGAIVNVLAIAAKTPGANSTPSSVSRAAGLALTKALSKELGPHAIRVNAVLVGIIESGQWARRAKEVGKPMESFLQEMARHAGIPLGRVGKAEEFADTVAFLLSPRGGYISGAAINVDGGLSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCE1</accession>
    <name>Q1DCE1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 5">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">galU</name>
        <name evidence="7" type="ORF">MXAN_1425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551542.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1425"/>
    <dbReference type="EnsemblBacteria" id="ABF93008">
        <property type="protein sequence ID" value="ABF93008"/>
        <property type="gene ID" value="MXAN_1425"/>
    </dbReference>
    <dbReference type="GeneID" id="41358871"/>
    <dbReference type="KEGG" id="mxa:MXAN_1425"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_7"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF93008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="32619" checksum="A0838034D4CC8950" modified="2006-07-11" version="1">MASKTSKVEPLIRKCVIPAAGLGTRFLPATKAVPKEMLPIVDTPTLQYIVEEAVSAGIEDVVLINGRGKGAIEDHFDIGFELETTLRARGKDSEADKLRAIADLVRVVSIRQKEPKGLGHAVLCAKSVIGDEPFGVLLGDDMIDAEEPGIRQLARVYRQYNQAVIALMEVPESETHMYGIAAGTDLGDGVMRIDRIVEKPKKGTAPSNLAVIGRYVLPPDIFPILENQTPGVGGEIQLTDGLATLQQSKGLLGYRFKGQRYDAGDKVGYLKANIAYALKRPDLRAGLLEYMREVVKTEKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS1</accession>
    <name>PDXH_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="1">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PNP/PMP oxidase</fullName>
            <shortName evidence="1">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxH</name>
        <name type="ordered locus">MXAN_1295</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF87165" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87165.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCS1"/>
    <dbReference type="SMR" id="Q1DCS1"/>
    <dbReference type="STRING" id="246197.MXAN_1295"/>
    <dbReference type="EnsemblBacteria" id="ABF87165">
        <property type="protein sequence ID" value="ABF87165"/>
        <property type="gene ID" value="MXAN_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1295"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_7"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255872" description="Pyridoxine/pyridoxamine 5'-phosphate oxidase">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="206" mass="23783" checksum="A1D845CDAC8A5196" modified="2006-10-31" version="2">MHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATVGDDGRPSARVVLLKDFDARGFVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRVERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEARVAEVEQKYAGQPVPRPPHWSGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS9</accession>
    <name>Q1DCS9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551404.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1287"/>
    <dbReference type="EnsemblBacteria" id="ABF92684">
        <property type="protein sequence ID" value="ABF92684"/>
        <property type="gene ID" value="MXAN_1287"/>
    </dbReference>
    <dbReference type="GeneID" id="41358733"/>
    <dbReference type="KEGG" id="mxa:MXAN_1287"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043531_0_0_7"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="466" mass="51419" checksum="C3E45FB60638E5A5" modified="2006-07-11" version="1">MRLTLIGHASLLIETADCRVLMDPVLWDPHQEGLFHVHPAREVLHARLPPLDVLVISHRHLDHFDIRSLAHLPRQVQVVVPQDPLLEKSLRALGFEEVHALAPLTEFFVGGTRFVTTPSRAPVREFGLVIQDETGTCFNAVDTVLDASAVAAVRQVAPTLDVFLASWQPMLEVDFQWNRPVAFPVQRYAELLGHVAALEPRAVVPGANGFRYCGISSWLNQVVFPVSRARFCVDVKRARGDCAVFPMDPGDVLEFGAAGFRLDAGGASFVRRLPEARVSLDYRPVDFDGRLVDGPCAPDEAAAIRASVERVMDVELPRFLEEADATCWRLHQQHGVVQQLEVVFPDERLSWCIDFTASPPRMARGASSLATVHSLVTASVLHGIASGTRTWDYAIMGGFYRRFLTFEPQAPLSDPLRLRFPSGQAQASVIEAEVARWAGVRPLSSARAPRALLQRCGVFPTGATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD08</accession>
    <name>Q1DD08_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91878">
        <property type="protein sequence ID" value="ABF91878"/>
        <property type="gene ID" value="MXAN_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1205"/>
    <dbReference type="HOGENOM" id="CLU_3082154_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="52" mass="5866" checksum="F361051C1824A240" modified="2006-07-11" version="1">MLVQLDLNFVGELSLSVAPADCLFPRSAVGRWIHEQHSREHRQVLARPVGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD32</accession>
    <name>Q1DD32_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551301.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1182"/>
    <dbReference type="EnsemblBacteria" id="ABF88658">
        <property type="protein sequence ID" value="ABF88658"/>
        <property type="gene ID" value="MXAN_1182"/>
    </dbReference>
    <dbReference type="GeneID" id="41358632"/>
    <dbReference type="KEGG" id="mxa:MXAN_1182"/>
    <dbReference type="eggNOG" id="ENOG50301RV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183870_1_1_7"/>
    <dbReference type="OMA" id="MCLGISI"/>
    <dbReference type="OrthoDB" id="2054882at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="76" mass="7828" checksum="96D6E6C5F7C0CD0E" modified="2006-07-11" version="1">MLLLGVVVSVQGVLASIIYSLIGLAVFVAGFYVIRLIMPFDVHKELEADQNTAVGIVIGSFIIGLAIIVAAAISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD50</accession>
    <name>Q1DD50_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551283.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1163"/>
    <dbReference type="EnsemblBacteria" id="ABF87784">
        <property type="protein sequence ID" value="ABF87784"/>
        <property type="gene ID" value="MXAN_1163"/>
    </dbReference>
    <dbReference type="GeneID" id="41358614"/>
    <dbReference type="KEGG" id="mxa:MXAN_1163"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448217_0_0_7"/>
    <dbReference type="OMA" id="ICRAIEY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="612" mass="65380" checksum="500441F0902987C8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD84</accession>
    <name>Q1DD84_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">frgB</name>
        <name evidence="6" type="ORF">MXAN_1129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551249.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1129"/>
    <dbReference type="EnsemblBacteria" id="ABF92788">
        <property type="protein sequence ID" value="ABF92788"/>
        <property type="gene ID" value="MXAN_1129"/>
    </dbReference>
    <dbReference type="GeneID" id="41358580"/>
    <dbReference type="KEGG" id="mxa:MXAN_1129"/>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534028_0_0_7"/>
    <dbReference type="OMA" id="FSAQMAH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="290"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="510" mass="53770" checksum="189D109223109747" modified="2006-07-11" version="1">MTGGMWISLLACAGQLALAGLALVRVGKSPLALPLSLLSIALSTWNFSGFALVRADEDGWRLVGFTAGLMTVPCALHFILSFVGRRRSLAWAMYGAYALFGALALAMLVALGAPTLEAHLLTLRFGLLVSALAIPILGGGFALLGFHVLHSRHPDERARAGLVLLGLTLVVALLMTELAAELGLEVVRLGHVGTLLGLPVMATAALRFGLFGDDPGAPRLALHAAGIAGLGVLAYLAVVRLFVAQAGTLIICTTAVTFALVAATRRGVTAYVSRSERLERLATLGRFSAQMAHDLKNPIAAMKGAAQYLKEEHARGRSWDGQGEFLDLLLEQVERLDRVVDTYQRLARVEPLPKPVDLRRLVEGVLSLQVFASPGKVVIIRELAAGLPPCAGDQDLLANALENLVRNACEAMPGGGTLTVRALRDGADVAMEVEDTGEGMDARTRERAFDDFFTTKASGSGLGLAFVRRVVEAHGGEVLLTSREGRGTVVRMRLPVTDASLGGAGVGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDV1</accession>
    <name>Q1DDV1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0911</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551032.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0911"/>
    <dbReference type="TCDB" id="2.A.3.3.18">
        <property type="family name" value="the amino acid-polyamine-organocation (apc) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90557">
        <property type="protein sequence ID" value="ABF90557"/>
        <property type="gene ID" value="MXAN_0911"/>
    </dbReference>
    <dbReference type="GeneID" id="41358370"/>
    <dbReference type="KEGG" id="mxa:MXAN_0911"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645324_0_0_7"/>
    <dbReference type="OMA" id="FNSDNRV"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="42576" checksum="B088260E537D380E" modified="2006-07-11" version="1">MGPFQLLSLGVNGIVGVGIFFAPAEVAALAPGASAIAAFALTGLALIPVALAFAVLGRRFDADGGPVLFARAAFGERASFLVGWVAYVSAFLSTAAVVAGLSQAVAPSLGLEGALGRSVLASVLVTALAGVVASGIRVSAGTWTALTVFKLLPLAALLVAFLALSGPPPAAAVAAGPVVDVSWLRAGLTVMFAYQGFEIVPVIAGQVRSSSRTVPLATVGSLLVAVLLYVGLVWACVAALPELASQAAPLAAAAGVWGGPGLEGWVKAGTSVSALGICLGMMVTTPRYLSALASGAHTLLGLDGMSAGGVPVRALAVTWALVLLFVNLGDLSELFALSSIAVLMQYGVTSAALAALAWRRERGLRPLHALLAVPTLGLGLTLVAFGANPREGVTMALTLIAGVVLLRLSRPRASEPSAALRGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DED0</accession>
    <name>Q1DED0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550853.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0725"/>
    <dbReference type="EnsemblBacteria" id="ABF92922">
        <property type="protein sequence ID" value="ABF92922"/>
        <property type="gene ID" value="MXAN_0725"/>
    </dbReference>
    <dbReference type="GeneID" id="41358197"/>
    <dbReference type="KEGG" id="mxa:MXAN_0725"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_3_7"/>
    <dbReference type="OMA" id="WGLGKRI"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="434" mass="47906" checksum="4C0D123A6E11C0B5" modified="2006-07-11" version="1">MASDPDDKLPPQGRFNRLRKLAGLSVQVGTDVLKSGAKRLSGSTPDLLSKEAAEKLVSTLGELKGAAMKMGQAISMDPDLLTPEVRQVLARLQNQAPSMSYAQVSRVVQAELGAPPESLFREFSEEPLAAASLGQVHRAVLEDGRAVAVKVQYPGIDVSLANDMANLGIVAKTASTVLRVSDAGAYFQEFRDEMLLELDYHREAELAEGFARSVAKLPELCVPAVISSHSAKRVLTLELLEGLTLKDWLPTNPSNEARFRVARQLILATYGPFFGAGEIHADPHPGNFMVMPDGRLGLLDFGSIKRFSPRFVDVNQRMLRQTMRMEPLDILSLSREVGFTVELPDDEAEDLITEVLRIAGRPMRLPDYDYAVCEINRDMRHHFSRNAPRFLKIRPPPEAMMFFRSTGGLAQNLRLIGARGDFRAVFLEVTDLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ2</accession>
    <name>Q1DEQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sigma-54 dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0603"/>
    <dbReference type="EnsemblBacteria" id="ABF90820">
        <property type="protein sequence ID" value="ABF90820"/>
        <property type="gene ID" value="MXAN_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0603"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012398_0_0_7"/>
    <dbReference type="OMA" id="IERSMAY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="673"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="918" mass="100187" checksum="E23D8C64E7A32F2A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF31</accession>
    <name>Q1DF31_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0472</name>
    </gene>
    <organism evidence="2 3">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Mackenzie C."/>
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                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
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            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="205" mass="23223" checksum="1E88C3B3AD67C38B" modified="2006-07-11" version="1">MDASSGKSGRPRNRGWTSDPDEIFGSSSRRSHTMKKTRDEALNLQEVGDMEARWRGLATQLLELGDDAMDAQLLVAFRAAREEGVVPPDAGFFLVAHILTAMADEAIGDEPRVCRLALELELMEREYGVEQGVWLSGEETPPEDWEALRAAYEAACDEARATFFTAYGEEEMARLYLDDRICFHRRFESGRRFFHGLPMLPEHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="7">Putative cation transporter/universal stress family protein</fullName>
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        <name evidence="7" type="ORF">MXAN_0260</name>
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    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DK1622</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABF92456">
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        <property type="gene ID" value="MXAN_0260"/>
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    <dbReference type="KEGG" id="mxa:MXAN_0260"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
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        <property type="entry name" value="UspA"/>
    </dbReference>
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    </dbReference>
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            <end position="23"/>
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            <end position="54"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        </location>
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        <location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00582"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF92456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFV4</accession>
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        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="643" mass="72227" checksum="B67C261C930D8863" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG07</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90001">
        <property type="protein sequence ID" value="ABF90001"/>
        <property type="gene ID" value="MXAN_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0132"/>
    <dbReference type="HOGENOM" id="CLU_3397535_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="31" mass="3428" checksum="8C591BDFE2D990E3" modified="2006-07-11" version="1">MVHDVFWLRVLAIALPPTVKAAHMATTDIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG39</accession>
    <name>Q1DG39_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
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            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550248.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0101"/>
    <dbReference type="EnsemblBacteria" id="ABF90511">
        <property type="protein sequence ID" value="ABF90511"/>
        <property type="gene ID" value="MXAN_0101"/>
    </dbReference>
    <dbReference type="GeneID" id="41357607"/>
    <dbReference type="KEGG" id="mxa:MXAN_0101"/>
    <dbReference type="eggNOG" id="ENOG5032JHX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743600_0_0_7"/>
    <dbReference type="OMA" id="PHNFWVL"/>
    <dbReference type="OrthoDB" id="973529at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="41151" checksum="C98F763C16172C32" modified="2006-07-11" version="1">MDSTAEFRDAFWKQDLRLPRGVELLRQDVFLLPRRGPGGQAIYELAEVVLPQVRVPVLMAYRAPLLPADVHSLRERLRAASVALDQRDGTAERLPVVRIPMIATDSASSGVIAACEQEDVALVDQRGTFFLRSGSTFIRVQGREPSQRRPREPVFHGKGCRIVRTLLQSPGEAQTVRALSERTQTSYSYAYGVVRHLVLDGYVEPVGKRSGFRLRAPVRLLRAWMASGEKTSVTLDGFNAPSTTPELLGKGLERLKAQGIRGIYTLASALLPEERFVSGLPHGLYLTGSIDAAVEAFGLRRLMPHNFWVLRAEPSAETDAGGVFFSPRTLPHGLGVALPQLTVDFHQSGGRGKEQADELVQRFAQALPISEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG62</accession>
    <name>Q1DG62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550225.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0078"/>
    <dbReference type="EnsemblBacteria" id="ABF91415">
        <property type="protein sequence ID" value="ABF91415"/>
        <property type="gene ID" value="MXAN_0078"/>
    </dbReference>
    <dbReference type="GeneID" id="41357585"/>
    <dbReference type="KEGG" id="mxa:MXAN_0078"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_7"/>
    <dbReference type="OMA" id="NMLPIPW"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="30375" checksum="07690178238E11CD" modified="2006-07-11" version="1">MGYRSLFAPGCFSNRTIVVTGGGSGIGRCTAHELAALGANVVLVGRKPDKLEAVAREIQEDGGKVSFEVLDIRDEEGVKATVARIIAAHGPIHGLVNNAGGQFPSPLSAISKKGFDAVVSTNLTGGFLMAREVYLQSMSSHGGSIVNMLADSWGGMPGMGHSGAARMGMLNLTQTAAVEWAASGVRVNAVAPGWVASSGMDSYKDEGVRAMIPLLKKEVPLQRLATESEVSAAIVFLLTDAAAFITGDVIKIDGGASCNTKIFPLEETTASKPYEGFHRASAPRILGGESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVR5</accession>
    <name>Q1CVR5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vegetative protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">vegA</name>
        <name evidence="2" type="ORF">MXAN_7401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7401"/>
    <dbReference type="EnsemblBacteria" id="ABF90235">
        <property type="protein sequence ID" value="ABF90235"/>
        <property type="gene ID" value="MXAN_7401"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7401"/>
    <dbReference type="HOGENOM" id="CLU_092039_0_0_7"/>
    <dbReference type="OMA" id="RTKGYCA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19356" checksum="749946E1694AD71B" modified="2006-07-11" version="1">MRIQRMSVDKAFRDMIRNEIEVQLKPLRDVVARLEEGTADLDALRNVAERLAPLAEVVGPLFGAQIPAAAKAGRRGPGRPPAARSAVTAAPAAVGGKRRGRKPAAAGADGSRACAIIGCGKPSRTKGYCAAHYQKLRMLEKTNRRPSDWKDYADPDSVDDIKLPRGRAASKALAAAAQAGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS4</accession>
    <name>Q1CVS4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92196">
        <property type="protein sequence ID" value="ABF92196"/>
        <property type="gene ID" value="MXAN_7392"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7392"/>
    <dbReference type="HOGENOM" id="CLU_976007_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="29689" checksum="EBA6813D9FF99FC4" modified="2006-07-11" version="1">MAAAKDSHGDEARHGDFQAGAGGQGEGGGRPGRHARRAGPPGHRGGDCAGSGQPPVQDSGHPGPRPREDGGGNGDAAHGQGGPRRHREWQAHEGPRAPQITVHQDGLRGRSEQSGGPQVRARTGRRRQARHREDAAPRHQGEARAEAPALRRGFSGRRSWTRPSLERRRSPSSAWERCASPYPDAGQWPLRGPLPRRRGPRRPSARAVRPAAPSGSSTRPAARPSASPPGPCADGSAGPRAACRAPAPRPPSRRRPAPALAAPLASAGTAAGRTARPAPASPRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW62</accession>
    <name>Q1CW62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557167.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7248"/>
    <dbReference type="EnsemblBacteria" id="ABF92555">
        <property type="protein sequence ID" value="ABF92555"/>
        <property type="gene ID" value="MXAN_7248"/>
    </dbReference>
    <dbReference type="GeneID" id="41364414"/>
    <dbReference type="KEGG" id="mxa:MXAN_7248"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670537_0_0_7"/>
    <dbReference type="OrthoDB" id="2110383at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="45047" checksum="1B9F3007B704F086" modified="2006-07-11" version="1">MDTLAALWRDPELRHAIGIIAMLSLLAPILVEVRRRKLRRAIELLDTHLEDVLEGRREEPGPQVEARALWRAIREQLVFPPGGQPMPRPALIRAEPSQGLRETCRALFRHSWGHALGKNLTGIALVMTFGLLGKVLVGPVREALMGGGAAGATQAVLLSAAIGQMGAKFFVSAMGLVGSFFFQAIASVQESRLLARLDAMRPRFESATQTLDAHGIVLATARRDALSALKGELVQTRRELSERLLHLESVEVSLQDIGTQVQTSFGTMMKEQVGDVITRQLSAVEKAVREIATDLQRSIASGFAATLQQEMSTVRDSLGSIQQSLSERQEHDLGRILEQLRDAVSGGFHSQSQDMARQMQELLGVLPRLEQQFEAMSHMMGTQARQWGAENQRAIDVLGARVTTVVESFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWM5</accession>
    <name>Q1CWM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557004.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7085"/>
    <dbReference type="EnsemblBacteria" id="ABF88779">
        <property type="protein sequence ID" value="ABF88779"/>
        <property type="gene ID" value="MXAN_7085"/>
    </dbReference>
    <dbReference type="GeneID" id="41364260"/>
    <dbReference type="KEGG" id="mxa:MXAN_7085"/>
    <dbReference type="HOGENOM" id="CLU_2650672_0_0_7"/>
    <dbReference type="OMA" id="CPMVKTE"/>
    <dbReference type="OrthoDB" id="1857258at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="89" mass="10170" checksum="DC2CC8D2726CD6B5" modified="2006-07-11" version="1">MHGCMSRGIDTPEMCPMVKTEDLIDAQAVAGLLRLRHANSVSTYLRRYPDMPRPVLDLGTGRPRLWLRPQVVRWMRARKPEQLRAGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWV5</accession>
    <name>Q1CWV5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90489">
        <property type="protein sequence ID" value="ABF90489"/>
        <property type="gene ID" value="MXAN_7005"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7005"/>
    <dbReference type="HOGENOM" id="CLU_105840_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188132" evidence="1">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="23962" checksum="2BFDEE493FB8CA2E" modified="2006-07-11" version="1">MGACMRRRLRFQGAFMGLLLAACSSTPAGPVEGADYGYRNGDVWVRGPWDAIIPSADVDAVIDQLCPAIMQLPRAQGREYGQEYCGAIYSLGDGTYYASLPSTLGPLLKATPEPQKACFAPRFVNDSRGRTVVLADYHSHSWANSRMSSADRRQSRQRFSIRIQFDTGCRVMKLVPYIGEARPGELFERRERKWVRIGVIKPEHKAAGIVTWMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX23</accession>
    <name>Q1CX23_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556856.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89368">
        <property type="protein sequence ID" value="ABF89368"/>
        <property type="gene ID" value="MXAN_6936"/>
    </dbReference>
    <dbReference type="GeneID" id="41364117"/>
    <dbReference type="KEGG" id="mxa:MXAN_6936"/>
    <dbReference type="HOGENOM" id="CLU_582440_0_0_7"/>
    <dbReference type="OrthoDB" id="534088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="469" mass="51535" checksum="8398CD2A8E724E08" modified="2006-07-11" version="1">MSARGTRVRQKPACALAPGDGGRAGALGLPMLHRESISSPKDWMAGAQASAQLFEEKPVLGGQMVSSRHNNLITAGTQLDTALRNLGKPLFAGLHARYQGGWAWMKVLIEQAESDWRHSPARGLHGIDLWGGPDQEPAAHYLKLGEKPIVPCGGGQWGDYNGDGAPDYLGVDPARWNHDVLRPLLIADNMNVDHATIDLCGEGSWQLYSEVFTGLGGLYNRTYHLVSTVYVRYTYWDTATNAWKSERVFTHRFTGGESLGVFVREQDRPTYNPNNTRNPQEWMAKRWGHVSQNIASFDYAGANDFRAAVRTRMVDVLKEQQRQFYGSIATRMGQAGDALQVQAKRMTGTRLLWQSYAALALPLSLDHDEHLRGLLYGEDAVLSGHDTPQDVEVTPVLNDVMDMYALFSATASPPAHNILADLHPAVTSRADRLKAAIDASLDAQAEAGGPEASAWVESTLLRLRLSVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX44</accession>
    <name>Q1CX44_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6915"/>
    <dbReference type="EnsemblBacteria" id="ABF91316">
        <property type="protein sequence ID" value="ABF91316"/>
        <property type="gene ID" value="MXAN_6915"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6915"/>
    <dbReference type="eggNOG" id="ENOG5031EBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1892667_0_0_7"/>
    <dbReference type="OMA" id="VMHAKKE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="17528" checksum="07F26DF89C011346" modified="2006-07-11" version="1">MRRSGPQGCQAGMGAHVWSAESSQEAHVVDLESERLERSQLETLSTAELIRHALAETRLLVRAEVMHAKKELREELKAARTAGILLGAGAVLALTALAVLFVALGLALPMAQALGVLVVGVVLLAIAGVLLFVGRKRVPKKPLPHTQERLKMDYQLTRETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXH6</accession>
    <name>Q1CXH6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556705.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6780"/>
    <dbReference type="EnsemblBacteria" id="ABF88394">
        <property type="protein sequence ID" value="ABF88394"/>
        <property type="gene ID" value="MXAN_6780"/>
    </dbReference>
    <dbReference type="GeneID" id="41363971"/>
    <dbReference type="KEGG" id="mxa:MXAN_6780"/>
    <dbReference type="HOGENOM" id="CLU_2194105_0_0_7"/>
    <dbReference type="OMA" id="YARRWPF"/>
    <dbReference type="OrthoDB" id="1806571at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="108" mass="12035" checksum="B388A2316C19F63F" modified="2006-07-11" version="1">MTLMAWPTVASPYERRSLTSGLRVRDESGAMLGYVALIGREHLYARRWPFSRQWTEFPLARVRHVSRGSVFLEGQMPGRVVAADKGAHAEIPTQTLPLAELDEASTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW4</accession>
    <name>Q1CXW4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron utilization domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6642"/>
    <dbReference type="EnsemblBacteria" id="ABF88962">
        <property type="protein sequence ID" value="ABF88962"/>
        <property type="gene ID" value="MXAN_6642"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6642"/>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2233627_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="105" mass="11273" checksum="5734861607FEDDEF" modified="2006-07-11" version="1">METLAPRLRRVCVEGESLKGVRGEPGHEVEFRVGPTAFRHDTPSLGDPARGALEVVFFLHGHGPGSTCRHAVQGVARLARLREARRAQQGLLGGRRAGPLIAAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY08</accession>
    <name>Q1CY08_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556523.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6595"/>
    <dbReference type="EnsemblBacteria" id="ABF86356">
        <property type="protein sequence ID" value="ABF86356"/>
        <property type="gene ID" value="MXAN_6595"/>
    </dbReference>
    <dbReference type="GeneID" id="41363796"/>
    <dbReference type="KEGG" id="mxa:MXAN_6595"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463686_0_0_7"/>
    <dbReference type="OMA" id="TIAICKF"/>
    <dbReference type="OrthoDB" id="1262117at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188027" evidence="3">
        <location>
            <begin position="33"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="593" mass="65762" checksum="E65521E046F64474" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY21</accession>
    <name>Q1CY21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87545">
        <property type="protein sequence ID" value="ABF87545"/>
        <property type="gene ID" value="MXAN_6582"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6582"/>
    <dbReference type="HOGENOM" id="CLU_949376_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="32705" checksum="10A0DAA26DE72FA3" modified="2006-07-11" version="1">MDACNMDTRLRRRQFLEPRDVRFTVESHRVGCPPTPATRRLRSVRRPRVLASHARAGIRLDLRAIRKRQLQVILTEEQGLVVIGGEGARPTVRDTHPRDGVLHGAASAPGEQCQDEQVPERPVRRVRCKVSAVHRAATFHGKTIIATLSRGRTAQPSWSGSNPCALWKPMRGRPKTMSIASEPSTAKYFEKRQRREVSGPVRSAGTKRGPAVSSPPTRAKAVRPKRRKPAPAPTLQRHAPERSMGVSSQKPKTYCSSFTSVRVSTMLDGRPARNWKRKRSRGNSQPAPSSHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYK5</accession>
    <name>Q1CYK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556326.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6394"/>
    <dbReference type="EnsemblBacteria" id="ABF87918">
        <property type="protein sequence ID" value="ABF87918"/>
        <property type="gene ID" value="MXAN_6394"/>
    </dbReference>
    <dbReference type="GeneID" id="41363605"/>
    <dbReference type="KEGG" id="mxa:MXAN_6394"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_2_6_7"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="PTHR23200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="29157" checksum="11FF527A67492492" modified="2006-07-11" version="1">MFLNVLLQGSGFPRLRSTVTLVQSQQRNILVDSGLCDDAGRLVLALKERGLTPDDVDVVVATHLHYDHCGNHLLFRNAQYVVGAKDFVENAHFIEAYHQDHTPGKAATSELLREHYQTVKEFYVRSIVREVTRNIGFYNRVLERDSRFVPVDGSHWLTEEVEVLPTPGHTHGHISVVAHRARTDDESTPRKILIAGDALFTRKTLVENAERELQLAQDTELYSHTRRKLLREYRHIIPGHDCLVDTAPSEPLEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYQ4</accession>
    <name>Q1CYQ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556277.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6345"/>
    <dbReference type="EnsemblBacteria" id="ABF87157">
        <property type="protein sequence ID" value="ABF87157"/>
        <property type="gene ID" value="MXAN_6345"/>
    </dbReference>
    <dbReference type="GeneID" id="41363559"/>
    <dbReference type="KEGG" id="mxa:MXAN_6345"/>
    <dbReference type="HOGENOM" id="CLU_1658890_0_0_7"/>
    <dbReference type="OMA" id="MAVNDRW"/>
    <dbReference type="OrthoDB" id="1844579at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="16507" checksum="0D7D596689CE6F9E" modified="2006-07-11" version="1">MKRLPSMPEFLAPLPLFAVALMAVNDRWLKPTFHNALTGKLSDVAICFFLPLYVSALLALVTRWPRARRVAVGAGFTACLYTALKVSQPAADLFCELLRPLGLPLGIRSFRAWADPTDLVTLPLVWAAVRYSRAAAREPSSLPAAPSTGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU9</accession>
    <name>Q1CYU9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ORF">MXAN_6299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556232.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6299"/>
    <dbReference type="EnsemblBacteria" id="ABF91802">
        <property type="protein sequence ID" value="ABF91802"/>
        <property type="gene ID" value="MXAN_6299"/>
    </dbReference>
    <dbReference type="GeneID" id="41363515"/>
    <dbReference type="KEGG" id="mxa:MXAN_6299"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_7"/>
    <dbReference type="OMA" id="PGCHCAV"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="361"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF91802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="477" mass="51530" checksum="9F3560F009A1BA49" modified="2006-07-11" version="1">MRRAKIVCTLGPASQSQEMLEALLENGMDVARLNFSHGSHEQHAENIAKLRAASLKVRKAVGILGDLQGPKIRTGRFVKGSTELKEGGTFHITTDETVPGTDEIVSTTYPFLAADVNPGDRILLDDGLLELKVLETDKQKLIRTQVIHGGTLKNNKGINLPGVAVRAEALTPKDREDLVFGIKAGVDYIALSFVRQPSDLDTARQAMAEVGRTVPIIAKLEKPEAIARLDAILDKTDGVMVARGDLGVEIPPEEVPAVQKDIIRRSNLRGLPVIVATQMLNSMIDNPRPTRAEASDVANAVFDGADAVMLSGETASGKFPIESVQMMERIILAAESSARTTQSLMRVLETPVGLPNHFPDVIARVACEAAKASNASLIAAFTLSGVTARLLSHYRPPVPIVAFSPNQEVRRRLSLLWGVVPRVLEPTQDTEAMVKRVEEELLARGLGRKGDRIVIVFGAPVGQPGKINSLRLHTIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ69</accession>
    <name>Q1CZ69_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556117.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6173"/>
    <dbReference type="EnsemblBacteria" id="ABF88753">
        <property type="protein sequence ID" value="ABF88753"/>
        <property type="gene ID" value="MXAN_6173"/>
    </dbReference>
    <dbReference type="GeneID" id="41363402"/>
    <dbReference type="KEGG" id="mxa:MXAN_6173"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516326_0_0_7"/>
    <dbReference type="OMA" id="AIAGWEC"/>
    <dbReference type="OrthoDB" id="2083869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
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            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="177" mass="20004" checksum="BF3FDE9E88244601" modified="2006-07-11" version="1">MSVRTVSELDALMARLAEGDRVAFTRVFELLWGPIQKLCLSLLRNEADAADAGQEAMHKILERASDFDKTRPAMPWALAIAGWECRTLARRRDRRRESQADAMPSCAGPHAEEEFLQRDLTAAAMAALGELSELDREVLIATFWDEAASVSGATLRKRRERALDRLRKTFRRLYGLD</sequence>
</entry>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Kim H.S."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="38"/>
            <end position="605"/>
        </location>
    </feature>
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            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
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            <end position="592"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="605" mass="66245" checksum="F88552A36FF31DAD" modified="2006-07-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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            </authorList>
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            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="37" mass="4228" checksum="C9EE19BD5E84087E" modified="2006-07-11" version="1">MMNFKNLMDRDDLELKAVMAVMAVYVMMGAVFLGQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR6</accession>
    <name>Q1CZR6_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Putative DNA helicase</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GeneID" id="41363211"/>
    <dbReference type="KEGG" id="mxa:MXAN_5972"/>
    <dbReference type="eggNOG" id="COG1112">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF87123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D009</accession>
    <name>Q1D009_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">YceI-like family protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">MXAN_5877</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF90219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5877"/>
    <dbReference type="EnsemblBacteria" id="ABF90219">
        <property type="protein sequence ID" value="ABF90219"/>
        <property type="gene ID" value="MXAN_5877"/>
    </dbReference>
    <dbReference type="GeneID" id="41363116"/>
    <dbReference type="KEGG" id="mxa:MXAN_5877"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_7"/>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188209" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="21763" checksum="886D5E0E372B8304" modified="2006-07-11" version="1">MKTSMKTAVALFFALPSIALASTWKVDDSHSSAGFSVRHMMVSNVTGSFNVKSGTLNLDDKDITKSKVEAVLDASTVNTGNAKRDEHLRAPDFFDTAKFPEITFKSTKVQKAGQGKLKVTGDLTMHGVTKPVVLDVTGPSKESKDPWGNTRTGVTATTKLNRKDFGLAYNQALEAGGVAVGEEVTVNLELSLVKQADAAATDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D051</accession>
    <name>Q1D051_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase helper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipase modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_5835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipase chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555786.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5835"/>
    <dbReference type="EnsemblBacteria" id="ABF86240">
        <property type="protein sequence ID" value="ABF86240"/>
        <property type="gene ID" value="MXAN_5835"/>
    </dbReference>
    <dbReference type="GeneID" id="41363073"/>
    <dbReference type="KEGG" id="mxa:MXAN_5835"/>
    <dbReference type="eggNOG" id="ENOG5030VG1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066623_0_0_7"/>
    <dbReference type="OMA" id="PRQWGRN"/>
    <dbReference type="OrthoDB" id="1011405at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004961">
        <property type="entry name" value="Lipase_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03280">
        <property type="entry name" value="Lipase_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="40074" checksum="A39EC83602393A55" modified="2006-07-11" version="1">MRLQANRVLGASAAILGLLLGWRILPVGQTAGAPPAPGPVSSQGRSGPTLVGAPASRPPMPGAVNAAAPAAESLALELEVLRLSLLERFGSRLHEPSVQLRMLEQLMRYFQTRSPDRWREELQTFLRRAFPGQYEALATLLRDRLDYEKWVKDNDAYLRGLDSKQRRAAVWDARNRLFGKETAQRLWASELKHHALVDALQVIDARQDLPLSEKLSAYKARLGEVYGDGAPAQLSRHSQETMNRFLALPSVQRELTGMTPAERARSLWAVRQEMGLNDEALRRWDALDQTRDARWEAGLRYMAERATLARTLSGDALEARLQEVRARYFGTEADVIAQEEASGLFRFTRPRQWGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0B6</accession>
    <name>Q1D0B6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2021" name="J. Biol. Chem." volume="296" first="100308" last="100308">
            <title>Structural characterization of Myxococcus xanthus MglC, a component of the polarity control system, and its interactions with its paralog MglB.</title>
            <authorList>
                <person name="Kapoor S."/>
                <person name="Kodesia A."/>
                <person name="Kalidas N."/>
                <person name="Ashish"/>
                <person name="Thakur K.G."/>
            </authorList>
            <dbReference type="PubMed" id="33493516"/>
            <dbReference type="DOI" id="10.1016/j.jbc.2021.100308"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555721.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="7CT3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A=1-120"/>
    </dbReference>
    <dbReference type="PDB" id="7CY1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="A=1-120"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D0B6"/>
    <dbReference type="STRING" id="246197.MXAN_5770"/>
    <dbReference type="EnsemblBacteria" id="ABF90799">
        <property type="protein sequence ID" value="ABF90799"/>
        <property type="gene ID" value="MXAN_5770"/>
    </dbReference>
    <dbReference type="GeneID" id="41363013"/>
    <dbReference type="KEGG" id="mxa:MXAN_5770"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161433_1_0_7"/>
    <dbReference type="OMA" id="LACSVMG"/>
    <dbReference type="OrthoDB" id="1643542at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="7CT3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7CY1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13122" checksum="8D4BD6C6420F5148" modified="2006-07-11" version="1">MSFRTHLESVVNQVEGALACSVMGFDGISVDTFQKDESAELDLNGAWVEYANLLTQLRNAAETLKTGTVSEVSVNSEKVLTVMRLVSPDYFLVLALHADGNFGKGRYVLRVTAPKVRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D6</accession>
    <name>Q1D0D6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carotenoid synthesis regulator CarF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">carF</name>
        <name evidence="8" type="ORF">MXAN_5750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555701.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5750"/>
    <dbReference type="EnsemblBacteria" id="ABF87487">
        <property type="protein sequence ID" value="ABF87487"/>
        <property type="gene ID" value="MXAN_5750"/>
    </dbReference>
    <dbReference type="GeneID" id="41362993"/>
    <dbReference type="KEGG" id="mxa:MXAN_5750"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065233_1_1_7"/>
    <dbReference type="OMA" id="RTQECIC"/>
    <dbReference type="OrthoDB" id="824493at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid_desat" evidence="7">
        <location>
            <begin position="67"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="281" mass="31210" checksum="02D4597978D29A0A" modified="2006-07-11" version="1">MKTQEIEKKVRQQDAQVLAQGYSPAIRAMEIAAIVSFVSLEVALVYRLWGTPYAGTWLLLSAVLLGYLAADFVSGFVHWMGDTWGSTEMPVLGKALIRPFREHHVDEKAITRHDFVETNGNNCLISLPVAIIALCLPMSGPGWVFCASFLGAMIFWVMATNQFHKWSHMDSPPALVGFLQRVHLILPPDHHRIHHTKPYNKYYCITVGWMNKPLTMVHFFPTAERLITWATGLLPRQDDIGAEAARALVVAAGGSEAPVVQAAKELLTQATVQEKPASTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0K4</accession>
    <name>Q1D0K4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555634.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5681"/>
    <dbReference type="EnsemblBacteria" id="ABF86825">
        <property type="protein sequence ID" value="ABF86825"/>
        <property type="gene ID" value="MXAN_5681"/>
    </dbReference>
    <dbReference type="GeneID" id="41362926"/>
    <dbReference type="KEGG" id="mxa:MXAN_5681"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048325_0_0_7"/>
    <dbReference type="OMA" id="PEHERWV"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="33481" checksum="5A95530004422F5A" modified="2006-07-11" version="1">MEKRTDWYEHPQYYEAIFGTDTVREVDFLQTLSERFGTGGKLWLEPACGAGRLVEEASSRGLRVVGYDISEAMLAHARKRLTPAQRRRVKLGPSRMESFSDPSLEGQVDLAHCLVSTFRYLDSEAAARQHLLGTRRLLKPGGIYVLGFHLTDYARARPEHERWVGQVGEDRVVCNTNEGLPEQRARRSPMRNRLRVTGPDKDWLIETQWYFRTYSNAQAAKLFRDAGMRVLAGYTFDYDINAPVERGSLRLDRVFVLQPDPESPSVDPAEPGRASARKAPKRASTPQKSRKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D122</accession>
    <name>Q1D122_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555466.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5508"/>
    <dbReference type="EnsemblBacteria" id="ABF91297">
        <property type="protein sequence ID" value="ABF91297"/>
        <property type="gene ID" value="MXAN_5508"/>
    </dbReference>
    <dbReference type="GeneID" id="41362762"/>
    <dbReference type="KEGG" id="mxa:MXAN_5508"/>
    <dbReference type="HOGENOM" id="CLU_1509060_0_0_7"/>
    <dbReference type="OMA" id="IDPKHET"/>
    <dbReference type="OrthoDB" id="1903233at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188251" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19450" checksum="DD8FA4265C70E9FF" modified="2006-07-11" version="1">MKKYLLPLACLFLASACRHLGNTPDWPPSEDIPPGTYVLITLQDAHSPQRRSTYVVDPRTGTVVERRDGKRAYAVADPQSLDTESTGEAAQAALAPTSRVTVAMSVNCRDTLTLPDGCVDLAIDPKHETSGDPNPIKDEKQRIAITERYVKQLAVNVLQTARRTGVQVHVPALKRPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1K7</accession>
    <name>Q1D1K7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555281.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5315"/>
    <dbReference type="EnsemblBacteria" id="ABF88238">
        <property type="protein sequence ID" value="ABF88238"/>
        <property type="gene ID" value="MXAN_5315"/>
    </dbReference>
    <dbReference type="GeneID" id="41362584"/>
    <dbReference type="KEGG" id="mxa:MXAN_5315"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077411_1_0_7"/>
    <dbReference type="OMA" id="TKDVEVC"/>
    <dbReference type="OrthoDB" id="1869568at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="30968" checksum="115AB34A26A4C437" modified="2006-07-11" version="1">MSRWVGQALPLSLRGGQTHHLTSRGDCTMTLRTLGLTLLGTAGLLTLSACKKEEPAAAPPAAAPAAKKEPHAASPIQAPEGAAAAPVAPAGKGVVKGTVKFTGTPPEAADIPASNDPACEGMATKDASVLVKDGNLQNVVVRVKGKVPGAPPAPATPVVVDQSKCTYVPRVQGAMAGQQVAFKNSDGTLHNVRGIAGTKPVFNVAQPPSGAPVERPLPADADVLKLKCDVHPWMSAFVVSNENPYFATTGADGAFALEGLPAGTYTVEAWHETLGSKTAEVTVTDDAPAEAAFSFSAEDASAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M5</accession>
    <name>Q1D2M5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554920.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4942"/>
    <dbReference type="EnsemblBacteria" id="ABF88623">
        <property type="protein sequence ID" value="ABF88623"/>
        <property type="gene ID" value="MXAN_4942"/>
    </dbReference>
    <dbReference type="GeneID" id="41362227"/>
    <dbReference type="KEGG" id="mxa:MXAN_4942"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002483_2_0_7"/>
    <dbReference type="OMA" id="TRFCGNG"/>
    <dbReference type="OrthoDB" id="365211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="501"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="584" mass="64249" checksum="FE80095044119B4B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2T1</accession>
    <name>Q1D2T1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554867.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4885"/>
    <dbReference type="EnsemblBacteria" id="ABF91547">
        <property type="protein sequence ID" value="ABF91547"/>
        <property type="gene ID" value="MXAN_4885"/>
    </dbReference>
    <dbReference type="GeneID" id="41362175"/>
    <dbReference type="KEGG" id="mxa:MXAN_4885"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1077324_0_0_7"/>
    <dbReference type="OMA" id="WILSVDP"/>
    <dbReference type="OrthoDB" id="1547128at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4384" evidence="1">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="27548" checksum="38D9D7C2EF8D7D21" modified="2006-07-11" version="1">MSAHESEWTLRRLSAGELAATEAARVQAHAASCETCAQALRGIQKAQTRFEAEVPFERFEASEEQALRRQQDSARPPPRRWVATTVAIAASLLVVVLVRPLLDSTAESGAIVGLNRLKGGATAELLIGGGLGPQREAIPDRPEALDLGERVIVGYKAGTHRYVAALSVDAIGEVTPLYPEAGASAPVAPGSGQHWLPGGWEFTGSGDERVIVVLSDEPLPQETLVEAARRAFAQADGDVGRMAELEVPGAQTHWVLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2X6</accession>
    <name>Q1D2X6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug resistance transporter, EmrB/QacA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554822.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4836"/>
    <dbReference type="EnsemblBacteria" id="ABF88259">
        <property type="protein sequence ID" value="ABF88259"/>
        <property type="gene ID" value="MXAN_4836"/>
    </dbReference>
    <dbReference type="GeneID" id="41362132"/>
    <dbReference type="KEGG" id="mxa:MXAN_4836"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_7"/>
    <dbReference type="OMA" id="IPGWVWR"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188312" evidence="6">
        <location>
            <begin position="24"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="487" mass="50541" checksum="FB2351E120EEA5E8" modified="2006-07-11" version="1">MRTTHRPLTTLALALSLFMAALEATVVSTAMPTVVGELGGIQHYAWVFTAYMLSSTITVPIYGKLADLYGRKPVLVFGIVLFLVGSIASGLSTSMAMLIGFRTLQGLGAGAMQPVALTVIGDIYTLEERAKVQGAFSAVWGIAGLIGPITGGFLVKYLTWHWVFFINVPVGVGCLVLLLSYFHERVERKPQKLDYAGAALLTGWVVALLVGVQGVGVNLWGLPVAAVLLAAFVAVERKVAEPIIPMSIFKVPAIVISSIAGALFSAAMFGATTYVPLFVQGVLGGTPTEAGGMITPMIVGWPLAALVAGKLLLKTGFRPLIVGGLGLTVVGTSLMALLLGPQAPRLLPEVAMGLFGIGMGFASTALLIAVQTSVGWELRGVATASNMFFRTIGGAIGVGLMGGVMVSQLLKDPTVPISAANALMSPDHGQDLPADLLATLSGALGTGLSINFWLICAFTVAAFAAGLFFPKVSRTTTVSSTEVVAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3R7</accession>
    <name>Q1D3R7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554533.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4538"/>
    <dbReference type="EnsemblBacteria" id="ABF87072">
        <property type="protein sequence ID" value="ABF87072"/>
        <property type="gene ID" value="MXAN_4538"/>
    </dbReference>
    <dbReference type="GeneID" id="41361840"/>
    <dbReference type="KEGG" id="mxa:MXAN_4538"/>
    <dbReference type="eggNOG" id="ENOG502Z921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058807_0_0_7"/>
    <dbReference type="OMA" id="GFPMLLD"/>
    <dbReference type="OrthoDB" id="829678at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="43790" checksum="2AFBCE81E77A40B9" modified="2006-07-11" version="1">MAGGFHAEDGADLVGDDDFVDAFGEDLLTTLNLDTWSQGLDLESVMARFRKEIASAVDKEGVVKKIIRQQVLPKISANSRGGAKEAGVYRATPEELATVHQSLLFSGKVEAVNSISTSHESLPIGITQIGIAAVGYGGTSGTFSQRLFRKEMSDQRSNPVQEALACIDQRMDRSASPRERSLSKLARRGIKTYAERAVLVDKSEAEWRIGHGNPCAYELITGSGYMSLLRESINVLRRLILQQKKFVFVPSTLEERGILTIGHALQAGEYVIFETLERYGRRVIEQWKYGDRSQNFAARFVQECCPEVISGVFRASERTPPRSFYAHRDHVHLAARVAMADSILRPDRGFPMLLDVAEASCRSAFGEDGFMGLVHDAYAQAGANLEFFNEHSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U4</accession>
    <name>Q1D3U4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554506.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4510"/>
    <dbReference type="EnsemblBacteria" id="ABF86043">
        <property type="protein sequence ID" value="ABF86043"/>
        <property type="gene ID" value="MXAN_4510"/>
    </dbReference>
    <dbReference type="GeneID" id="41361817"/>
    <dbReference type="KEGG" id="mxa:MXAN_4510"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016564_1_1_7"/>
    <dbReference type="OMA" id="HLGMAHE"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="429"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="657" mass="70614" checksum="FEAC54B7FE2A17FA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3V7</accession>
    <name>Q1D3V7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554493.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4497"/>
    <dbReference type="EnsemblBacteria" id="ABF88275">
        <property type="protein sequence ID" value="ABF88275"/>
        <property type="gene ID" value="MXAN_4497"/>
    </dbReference>
    <dbReference type="GeneID" id="41361805"/>
    <dbReference type="KEGG" id="mxa:MXAN_4497"/>
    <dbReference type="eggNOG" id="ENOG5032C5Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_2_1_7"/>
    <dbReference type="OMA" id="ERAMPVK"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="17381" checksum="53AD0CCF26D63717" modified="2006-07-11" version="1">MSGDLWPLHTFRFELTFQPEPLSGSGPEEAPVDGAFSECTGLEATMEPKAIRVGGHNLGAVQRAGPVSFGTVVLKRGLSSGERLARWFMRVTDGDYGYRCTVRIRLKAPSENGGTQTVLTYKLERAMPVKFKAADFNARATDVGIEELHLVHEGLSLED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D445</accession>
    <name>Y4406_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0060 membrane protein MXAN_4406</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_4406</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0060 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554406.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D445"/>
    <dbReference type="SMR" id="Q1D445"/>
    <dbReference type="EnsemblBacteria" id="ABF89645">
        <property type="protein sequence ID" value="ABF89645"/>
        <property type="gene ID" value="MXAN_4406"/>
    </dbReference>
    <dbReference type="GeneID" id="41361719"/>
    <dbReference type="KEGG" id="mxa:MXAN_4406"/>
    <dbReference type="eggNOG" id="COG1742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117653_2_0_7"/>
    <dbReference type="OMA" id="WLWAVEG"/>
    <dbReference type="OrthoDB" id="1991345at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000282238" description="UPF0060 membrane protein MXAN_4406">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <sequence length="109" mass="11772" checksum="92A6DCF3C90EEE4A" modified="2006-07-11" version="1">MNLLYAFGLFVLTAVAEVVGCYLPYLWLRQGKSPLLLVPAAGSLAVFAWLLTLHPTGAARTYAAYGGVYIAVALVWLWLVEGERPTTWDLVGALVAILGMAIIVLGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D462</accession>
    <name>Q1D462_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-lysine 5,6-aminomutase, alpha subunit</fullName>
            <ecNumber evidence="2">5.4.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kamD</name>
        <name evidence="2" type="ORF">MXAN_4388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554389.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4388"/>
    <dbReference type="EnsemblBacteria" id="ABF90868">
        <property type="protein sequence ID" value="ABF90868"/>
        <property type="gene ID" value="MXAN_4388"/>
    </dbReference>
    <dbReference type="GeneID" id="41361698"/>
    <dbReference type="KEGG" id="mxa:MXAN_4388"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517447_0_0_7"/>
    <dbReference type="OMA" id="SGLCMPE"/>
    <dbReference type="OrthoDB" id="346908at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047826">
        <property type="term" value="F:D-lysine 5,6-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="1">
        <location>
            <begin position="7"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="516" mass="57814" checksum="E7857E365AB8AB0F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4D8</accession>
    <name>Q1D4D8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4310"/>
    <dbReference type="EnsemblBacteria" id="ABF90431">
        <property type="protein sequence ID" value="ABF90431"/>
        <property type="gene ID" value="MXAN_4310"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4310"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766879_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188215" evidence="2">
        <location>
            <begin position="32"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="38116" checksum="E702AFAF97F1A333" modified="2006-07-11" version="1">MAPMERATRRTRTVLSLCLLALAGMARPGRAEEVVEEGPRLEFREALQLRIDQGLSAAGAAAVSLRRGRVGLHLTGSPWVRGGLEVSFDRLVLLPGPLQGPPLALHEASVTFTVMPQRAWLSVGLFRPQVGRESLTSGFEVDSLDKAITQGPLREHLTGTESGRAPGVDVGGLLRGEGWSVRYDSGVVVYRPGPEGAWRPPLLVARAALTLGAPEADVYSLSLPMNDFGLRPGLTLALQGSTEPGGDARSWGVDALLRLRPLVLSAELHQVASPQGHALLAHVRAGLNLPGPGATVLEPWALVARVTGGALADAPGGARLDAGLSWYLRRQALRATLGGSWRPPGHAASGGHLGLSLQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U2</accession>
    <name>Q1D4U2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4156"/>
    <dbReference type="EnsemblBacteria" id="ABF89165">
        <property type="protein sequence ID" value="ABF89165"/>
        <property type="gene ID" value="MXAN_4156"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4156"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022008_0_0_7"/>
    <dbReference type="OMA" id="WEAPLDL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="550" mass="58766" checksum="4BDCB5776E4C57B4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Z9</accession>
    <name>Q1D4Z9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dmpA</name>
        <name evidence="3" type="ORF">MXAN_4096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554102.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4096"/>
    <dbReference type="EnsemblBacteria" id="ABF87912">
        <property type="protein sequence ID" value="ABF87912"/>
        <property type="gene ID" value="MXAN_4096"/>
    </dbReference>
    <dbReference type="GeneID" id="41361425"/>
    <dbReference type="KEGG" id="mxa:MXAN_4096"/>
    <dbReference type="eggNOG" id="COG3191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024709_0_0_7"/>
    <dbReference type="OMA" id="CHAAIFK"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="47547" checksum="D3AE0741E02BF997" modified="2006-07-11" version="1">MVHIPEETGPRVRARELGLPLGRFKPGKFNAITDVEGVLVGHSTLIRGEGPLRPGHGPVRTGVTAILPNQGNIFMERMTGGGFVLNGAGEVAGMTQLMEWGLIETPILLTNTMAVGAVSDGVARYLVDRYPGIGDEHDVIIPVVGECDDSWLNDISGRHVREEHVFEAINNASTGPVAEGNVGGGTGMVTCDFKGGIGTSSRKLPEVLGGYTLGVLVMSNFGKMHNLRVGGMPVGEVLAEKFKGTPKRGQTYGSIIAVVATDAPLLSHQINRLCKRVALGIGRVGSYAAHGSGEIVVGFSTANIIPRRTQKMVYKLKLLLDQRLDPLYEAVMEATEEAILNAMCMATSMTGANGNHCPALPLGEVRRFLDAYKPIFASVKKRPQQSSAPAAKERPSNEDREGDVTVSTARPTQVRSAEGIPFPTRPAPDDTGEPGGPEGSSSGSPPGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D559</accession>
    <name>Q1D559_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554043.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4035"/>
    <dbReference type="EnsemblBacteria" id="ABF85924">
        <property type="protein sequence ID" value="ABF85924"/>
        <property type="gene ID" value="MXAN_4035"/>
    </dbReference>
    <dbReference type="GeneID" id="41361366"/>
    <dbReference type="KEGG" id="mxa:MXAN_4035"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_5_3_7"/>
    <dbReference type="OMA" id="ADWTHPI"/>
    <dbReference type="OrthoDB" id="1819702at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="220" mass="24735" checksum="0F658922C520B115" modified="2006-07-11" version="1">MSLVLYGHPFSSYTQKVLIALYENGTPFEFRCIGPETPQHSAEWSRRWPLRKFPLLVDGERDIAETSIIIEYLQLAHPGPVRLLPADPMAALDVRFLDRFFDLHVMNAAQHAVDGALTGDSVKRQEGLALAVKKLEVAYAWLEGQLAGRTWAAPGEDFTLADCAAAPSLFYADWTHRISDAFPVLRAYRSRLLARPSFARAVNEARRFRPLFPLGAPDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D574</accession>
    <name>Q1D574_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554029.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4020"/>
    <dbReference type="EnsemblBacteria" id="ABF88063">
        <property type="protein sequence ID" value="ABF88063"/>
        <property type="gene ID" value="MXAN_4020"/>
    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_95_2_7"/>
    <dbReference type="OMA" id="VGACQGM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR025662">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHFIS"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
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    </dbReference>
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            <end position="123"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="630" mass="69983" checksum="83DE132B7120EA60" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L8</accession>
    <name>Q1D5L8_MYXXD</name>
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        <name evidence="3" type="ORF">MXAN_3875</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89402">
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        <property type="gene ID" value="MXAN_3875"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="757"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="812"/>
            <end position="843"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89402.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5N7</accession>
    <name>Q1D5N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="VEVAWPP"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="499" mass="55617" checksum="0F97B27671884623" modified="2006-07-11" version="1">MSPRPALFGWPRKEELSLTAAMATGFALFFVAVYGGASWLTGFYTGGLRVELSFERHIPFMPPWALVYVSMDVLLLLSLFVFRTWRDMVPFALALCVETALAAVCFLLFPVEVAWPPRAVEGAWAGVFQLADTLNLERNYLPSLHVAFACTAALAYAERAGVLGRILFGLWALAIAASTLLIHEHHVVDVVAGALLAWGTWRWVAPWARRTAFLEALRVEALCARESYRFARRHLRYGLIALVLYRYAVSRWWREARGARVGFCFLQLVDDVLDGDRAVDGEPLDWVDALLWELESGRGEDRGTAATLGRVLLEQLGDDTARAQVFALVRTMRKDRERVKAGQWWSAEALRAQQRDTFCLSVDLMLHVAGAGVRAEDAPALMEAFGWCSVMRDLREDLAQGLYNVPEEVAAAVRGDGADPTDIDALLGTEAGRAWMTAEHVRARALLDGTAGQLAALEGRPGLALLRLFHRSIESFWRKRLPRRHPFLAEVTARRLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D657</accession>
    <name>Q1D657_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH-type transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GbsR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_3679"/>
    </dbReference>
    <dbReference type="GeneID" id="41361014"/>
    <dbReference type="KEGG" id="mxa:MXAN_3679"/>
    <dbReference type="eggNOG" id="COG1510">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_107540_2_0_7"/>
    <dbReference type="OMA" id="GNVIEFW"/>
    <dbReference type="OrthoDB" id="1646730at2"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="99"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90270.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N5</accession>
    <name>Q1D6N5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_3493</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ABF86214"/>
        <property type="gene ID" value="MXAN_3493"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="41" mass="4422" checksum="FE408338EF474E56" modified="2006-07-11" version="1">MRLGVEGALPVEAVPEVSVRSWFAKRAPAKRGAIRSPSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D726</accession>
    <name>Q1D726_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_3349"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_3349"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="FEQQTYY"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="579" mass="58261" checksum="5E43BFA03C4169CB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D757</accession>
    <name>RL30_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">MXAN_3317</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D757"/>
    <dbReference type="SMR" id="Q1D757"/>
    <dbReference type="STRING" id="246197.MXAN_3317"/>
    <dbReference type="EnsemblBacteria" id="ABF87599">
        <property type="protein sequence ID" value="ABF87599"/>
        <property type="gene ID" value="MXAN_3317"/>
    </dbReference>
    <dbReference type="GeneID" id="41360670"/>
    <dbReference type="KEGG" id="mxa:MXAN_3317"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_0_7"/>
    <dbReference type="OMA" id="MAFKVKH"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000347124" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="89" mass="9720" checksum="4E95286BC1491E21" modified="2006-07-11" version="1">MALKVKLVKSFAGASSDMLDTIRGLGLKKFGDERLLKDTPAVRGMAFKVKHLVTLETVSGDAPAPKRRKPAKIALRERAIAYQAKQNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7G8</accession>
    <name>Q1D7G8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="6">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">relA</name>
        <name evidence="6" type="ORF">MXAN_3204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3204"/>
    <dbReference type="EnsemblBacteria" id="ABF91365">
        <property type="protein sequence ID" value="ABF91365"/>
        <property type="gene ID" value="MXAN_3204"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3204"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_7"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="402"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="681"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="753" mass="84737" checksum="C9F891E7D6B0144C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J1</accession>
    <name>Q1D7J1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553228.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3179"/>
    <dbReference type="EnsemblBacteria" id="ABF86823">
        <property type="protein sequence ID" value="ABF86823"/>
        <property type="gene ID" value="MXAN_3179"/>
    </dbReference>
    <dbReference type="GeneID" id="41360535"/>
    <dbReference type="KEGG" id="mxa:MXAN_3179"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789467_0_0_7"/>
    <dbReference type="OrthoDB" id="112275at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="39719" checksum="48C79ED8714D2073" modified="2006-07-11" version="1">MQRSQQQRQGEWRPSGKCVRYRSSEGDAKHEDRAAPVGIEERDEPATELPQQVDEHHHHQGGEQRVVPARHGIEKKARELLEVRPDYTSVNHVAPGIAWVEFPELGQRIAKAAGVPFHGGGPEASATIIRESGKRSIVASLRARGTGKNLTMFSRMLFVNPPADGVAWEQAIGRRHRQGQLADEVEVELYQHTDELVGAFQKARDFARFIEQTEGTPQKQNFATHDCVKHQSASANVPPIYRLRSTLTIAARPSHWSRGRSDNHVLDTRGSIRQIHLKLATIRRLAFNPTTLLNIYHRPIRNNRGGLSPRRLGTSIVGVLRPLSVRLIFSLGICREKENREHCTYYDMHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J5</accession>
    <name>Q1D7J5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553224.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3175"/>
    <dbReference type="EnsemblBacteria" id="ABF86921">
        <property type="protein sequence ID" value="ABF86921"/>
        <property type="gene ID" value="MXAN_3175"/>
    </dbReference>
    <dbReference type="GeneID" id="41360533"/>
    <dbReference type="KEGG" id="mxa:MXAN_3175"/>
    <dbReference type="HOGENOM" id="CLU_1407464_0_0_7"/>
    <dbReference type="OMA" id="YGGAICT"/>
    <dbReference type="OrthoDB" id="1770092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187961" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="19776" checksum="EF66E975C42073C8" modified="2006-07-11" version="1">MTRNVKRFLAGSLLSLTPSIAFAGQIELDFPDFLTQRSEYVSLREGAVQVPVRKGPSVEAIGPAVEDFFVSNQAGVDLHLGIQILTGSFNGTWNTHPVPPSTYGGFQVGAPAPAPTVIQQYYYTVDPANPAGSKTCVWRVEVTDNAGACNAQVFFGTYGGAICTVDAAQSSIDPVTCQTQVVTNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L1</accession>
    <name>Q1D7L1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553208.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3159"/>
    <dbReference type="EnsemblBacteria" id="ABF90602">
        <property type="protein sequence ID" value="ABF90602"/>
        <property type="gene ID" value="MXAN_3159"/>
    </dbReference>
    <dbReference type="GeneID" id="41360518"/>
    <dbReference type="KEGG" id="mxa:MXAN_3159"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318821_0_0_7"/>
    <dbReference type="OMA" id="FIWANNN"/>
    <dbReference type="OrthoDB" id="11597at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187963" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120885" checksum="7B0D63447001418F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7M3</accession>
    <name>Q1D7M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553197.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3147"/>
    <dbReference type="EnsemblBacteria" id="ABF88283">
        <property type="protein sequence ID" value="ABF88283"/>
        <property type="gene ID" value="MXAN_3147"/>
    </dbReference>
    <dbReference type="GeneID" id="41360506"/>
    <dbReference type="KEGG" id="mxa:MXAN_3147"/>
    <dbReference type="eggNOG" id="COG2311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039610_0_0_7"/>
    <dbReference type="OMA" id="ALIYIHI"/>
    <dbReference type="OrthoDB" id="1742337at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="255"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="442" mass="48463" checksum="DC4E3E435C5B1E53" modified="2006-07-11" version="1">MPTAPSSDASAPRSEARPVEAGERLELLDALRGFALFGILISNVQMWFSGRVFPSREQFEASIASASLLDTITRYAFEVLVSGKFITLFAFLFGLGFAVQLGRVEARGGGFVPLYVRRLTVLLVVGVLHLFLLWYGDILSSYALMGFCLLLLRRRSERTLLIIAAVLVLVWPLLMSLLWRLPQLLADSPEAGAAVMAAAREKTSAIHARMLTAITGGSWWDVTKTSAGFYRDEFFTMMLAGLLTCLGRFALGLWAGRRGIFQDVPSHLGFFRRLLGWGLVAAVVGSVPGVVVTVLMQKKVLTPETMPVWLPLVLAPLRNLAQVGLAGVYLAGITLLFQRATWQRALGLLAPAGRMALTNYLSQTVISLLIFYGYGLGQVGKRGPFACVVICVGVFCVQVLWSHLWLSRFRFGPVEWAWRSLTYGKAQAMRRAASDTPAPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7S7</accession>
    <name>Q1D7S7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3093"/>
    <dbReference type="EnsemblBacteria" id="ABF87723">
        <property type="protein sequence ID" value="ABF87723"/>
        <property type="gene ID" value="MXAN_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3093"/>
    <dbReference type="eggNOG" id="COG5184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522462_0_0_7"/>
    <dbReference type="OMA" id="YSVMTAP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="584" mass="61591" checksum="4ECB063B29EC79CA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U3</accession>
    <name>RPOB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">MXAN_3077</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553127.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7U3"/>
    <dbReference type="SMR" id="Q1D7U3"/>
    <dbReference type="STRING" id="246197.MXAN_3077"/>
    <dbReference type="EnsemblBacteria" id="ABF90369">
        <property type="protein sequence ID" value="ABF90369"/>
        <property type="gene ID" value="MXAN_3077"/>
    </dbReference>
    <dbReference type="GeneID" id="41360439"/>
    <dbReference type="KEGG" id="mxa:MXAN_3077"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_0_7"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000300356" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1408" mass="157532" checksum="864B06F9E379B6ED" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D836</accession>
    <name>Q1D836_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2978"/>
    <dbReference type="EnsemblBacteria" id="ABF89610">
        <property type="protein sequence ID" value="ABF89610"/>
        <property type="gene ID" value="MXAN_2978"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2978"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_1_1_7"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="147"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23378" checksum="F9703E7E527821D4" modified="2006-07-11" version="1">MGAASVSETVVEEAAARKQTLREELTARRKAMTPDLIDTRGLKVQSRFLAAPYYQKARTVALYAPIRGEVPTRDILIAALQDGKIVCYPLSHVHGRILSFRAIKSESELEPGRLGVREPTNSADLIAVDQIDLFVVPGLGFTREGKRLGRGGGYYDATLRAASQRSRRVGLAFNDQVVPVLPTTGDDVDMDLVVTESESLRGLYRDWDFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D868</accession>
    <name>Q1D868_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553002.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2945"/>
    <dbReference type="EnsemblBacteria" id="ABF88086">
        <property type="protein sequence ID" value="ABF88086"/>
        <property type="gene ID" value="MXAN_2945"/>
    </dbReference>
    <dbReference type="GeneID" id="41360308"/>
    <dbReference type="KEGG" id="mxa:MXAN_2945"/>
    <dbReference type="eggNOG" id="ENOG5032TNB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109759_0_0_7"/>
    <dbReference type="OMA" id="PTTGHER"/>
    <dbReference type="OrthoDB" id="1939127at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="21618" checksum="17B662B2DB8A9A6A" modified="2006-07-11" version="1">MSGHAMSTVLPCELRRDGDRLFDVSMWCLGRDVLCPEGNLLVRRGLVRHARPEGAEGQSPYTVGLPDGGRLTLWGFGALCECGEAIFVPRAGFAPVLLEGVPGHLPFRAEELGPARLPTTGHERRALRAGLASLAGWLAEHEDWISSEMGPSWRRECFGARRKAAPVEADGLASAWRRFASRLRSLDSGFNVCTAPVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8A2</accession>
    <name>Q1D8A2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase Pkn7</fullName>
            <ecNumber evidence="4">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pkn7</name>
        <name evidence="4" type="ORF">MXAN_2910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2910"/>
    <dbReference type="EnsemblBacteria" id="ABF86569">
        <property type="protein sequence ID" value="ABF86569"/>
        <property type="gene ID" value="MXAN_2910"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2910"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_151_1_7"/>
    <dbReference type="OMA" id="PHLAEND"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="779" mass="84773" checksum="F7E777AE54D37F52" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8F4</accession>
    <name>Q1D8F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2858"/>
    <dbReference type="EnsemblBacteria" id="ABF92002">
        <property type="protein sequence ID" value="ABF92002"/>
        <property type="gene ID" value="MXAN_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2858"/>
    <dbReference type="HOGENOM" id="CLU_2753673_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="70" mass="7170" checksum="20DB6009CEBC1716" modified="2006-07-11" version="1">MPVNAGRPCSLGMQSKRDGGSDLYDALIIGSGAGGGPLPLKFSQAGLHVLANSFRSADPIVRRVQAGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G5</accession>
    <name>Q1D8G5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552908.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2847"/>
    <dbReference type="EnsemblBacteria" id="ABF90097">
        <property type="protein sequence ID" value="ABF90097"/>
        <property type="gene ID" value="MXAN_2847"/>
    </dbReference>
    <dbReference type="GeneID" id="41360218"/>
    <dbReference type="KEGG" id="mxa:MXAN_2847"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040905_0_0_7"/>
    <dbReference type="OMA" id="YATDFHN"/>
    <dbReference type="OrthoDB" id="1242971at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017549">
        <property type="entry name" value="APMV_L690"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03118">
        <property type="entry name" value="PEPCTERM_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="417" mass="43267" checksum="712B3764A0562B87" modified="2006-07-11" version="1">MFIQRRPPNLLLNEHTAVRRLRGGIMMNTRRSTLVHGVLSAAVAVLAVPVARAATPPAPPADCSVAGGYTQRNLVANSPALGAEHVDPHLVNAWGLAFNPMGIAWVANEGTGTSTLYDGNGVQQSLVVGIPAPPGVTESGEPTGVVFNGSEAFVVTGTGVSGPARFIFATEEGVLAAWAPAVDEASAKIVADNSAMGSVYKGLAMAGTGADAKLYAADFRNGRIDVFNSSFTPMPMPGAFADPSLPAGYAPFNIQDIEGTLYVSYAQQDKERTDDVPGAGAGYINAFDMNGQLLRRFASQGALDAPWGMALAPAGFGQFSNHLLVGNFGDGAINAYDPASGAWAGALTRPDGHPVKVDGLWSLHFGTGVQGLPAETLFFTAGPADEEQGLYGRLDMTPVCPQGGLPPWKAPHEPEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P3</accession>
    <name>Q1D8P3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552830.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2763"/>
    <dbReference type="EnsemblBacteria" id="ABF92138">
        <property type="protein sequence ID" value="ABF92138"/>
        <property type="gene ID" value="MXAN_2763"/>
    </dbReference>
    <dbReference type="GeneID" id="41360140"/>
    <dbReference type="KEGG" id="mxa:MXAN_2763"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_79_7"/>
    <dbReference type="OMA" id="HIRIETV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="162"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="404"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="521" mass="56617" checksum="29747694C5AB086C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q3</accession>
    <name>Q1D8Q3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552820.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2753"/>
    <dbReference type="EnsemblBacteria" id="ABF86298">
        <property type="protein sequence ID" value="ABF86298"/>
        <property type="gene ID" value="MXAN_2753"/>
    </dbReference>
    <dbReference type="GeneID" id="41360130"/>
    <dbReference type="KEGG" id="mxa:MXAN_2753"/>
    <dbReference type="eggNOG" id="COG5470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145407_1_2_7"/>
    <dbReference type="OMA" id="QYTQRAP"/>
    <dbReference type="OrthoDB" id="1534521at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="11935" checksum="3E40B30C195FD937" modified="2006-07-11" version="1">MPAYVLVEVSVHDAQTYERYKQLAPPSLKAYGGRYLVKGGPTQALEGTWQPPRFVLLEFPSVELARAWWASPEYAAAKALRHESAHSIMLLVEGVPATTPVTEVGESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y2</accession>
    <name>Q1D8Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552742.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2674"/>
    <dbReference type="EnsemblBacteria" id="ABF90062">
        <property type="protein sequence ID" value="ABF90062"/>
        <property type="gene ID" value="MXAN_2674"/>
    </dbReference>
    <dbReference type="GeneID" id="41360052"/>
    <dbReference type="KEGG" id="mxa:MXAN_2674"/>
    <dbReference type="HOGENOM" id="CLU_153018_0_0_7"/>
    <dbReference type="OMA" id="VRIYIVP"/>
    <dbReference type="OrthoDB" id="1636893at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14928" checksum="6CDDEFCF2E0E0E3E" modified="2006-07-11" version="1">MMRALDSLKRGFYKARPLGAALVALWAVSAGAEVINGAQLPDGSKRVGENRYRSPRDFDGTLEYYRAVYSTSGYPRRQIVNQPGVKAVHISNPSGKNFAGLNIYEANDEVRIYIVPTQQAAKPAKKPETTKSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D939</accession>
    <name>Q1D939_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552685.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2615"/>
    <dbReference type="EnsemblBacteria" id="ABF91213">
        <property type="protein sequence ID" value="ABF91213"/>
        <property type="gene ID" value="MXAN_2615"/>
    </dbReference>
    <dbReference type="GeneID" id="41359992"/>
    <dbReference type="KEGG" id="mxa:MXAN_2615"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081349_0_0_7"/>
    <dbReference type="OMA" id="SALECSI"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="29327" checksum="ED6D5B8CA89972A3" modified="2006-07-11" version="1">MQLTSASELPLRTLSTLFARAFEGYFVTVPDAPGLFDARVRSEHISLEESRVARVDGEPVGLVLMARRGRESRVAGMGVVPAWRNRKLGGAMLRPLLEDARARGDTRMLLEVIEQNAPAVTLYERLGFQRVRRLVGFMGTPEPWVGASALEEVDPWECARLLPEGLPWQLAPATVMGLALPARAFRLGPAVAMVADVSAPTLVVRSVGVEPSARGQGAGRRLLGALAARWPGKALAVSAVVPEGPLARFFQGAGLGATPLTQLELELPLEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D952</accession>
    <name>Q1D952_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552672.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2602"/>
    <dbReference type="EnsemblBacteria" id="ABF90194">
        <property type="protein sequence ID" value="ABF90194"/>
        <property type="gene ID" value="MXAN_2602"/>
    </dbReference>
    <dbReference type="GeneID" id="41359979"/>
    <dbReference type="KEGG" id="mxa:MXAN_2602"/>
    <dbReference type="eggNOG" id="COG1996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370910_0_0_7"/>
    <dbReference type="OMA" id="RALVWKC"/>
    <dbReference type="OrthoDB" id="1207224at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22045" checksum="EADEF327B19388FC" modified="2006-07-11" version="1">MAFRFLAVPAHRLVNFPQTLPDDERLEPELPPVHEAVERALTGAEFRDMRAKDRLRILLQGDRPPSLGAPETGFGPSAIFAHPPQDLPALLRLADELENLARREAGERALVWKCGDCGARYAVPVALVRQVSIRCERCGTPVELAATRSLGEESLIDPFLGAVNHSRRELAAFFREAMARGWPVLVAEDKRVPRTQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D972</accession>
    <name>Q1D972_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thymidylate kinase</fullName>
            <ecNumber evidence="3 6">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tmk</name>
        <name evidence="8" type="ORF">MXAN_2582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552652.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2582"/>
    <dbReference type="EnsemblBacteria" id="ABF86769">
        <property type="protein sequence ID" value="ABF86769"/>
        <property type="gene ID" value="MXAN_2582"/>
    </dbReference>
    <dbReference type="GeneID" id="41359960"/>
    <dbReference type="KEGG" id="mxa:MXAN_2582"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477201_0_0_7"/>
    <dbReference type="OMA" id="CITDRYL"/>
    <dbReference type="OrthoDB" id="223888at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="7">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="566" mass="62065" checksum="7177FB414CFAAA8B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D975</accession>
    <name>Q1D975_MYXXD</name>
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        <submittedName>
            <fullName evidence="7">Metallophosphoesterase/PKD domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">MXAN_2579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF91089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2579"/>
    <dbReference type="EnsemblBacteria" id="ABF91089">
        <property type="protein sequence ID" value="ABF91089"/>
        <property type="gene ID" value="MXAN_2579"/>
    </dbReference>
    <dbReference type="GeneID" id="41359957"/>
    <dbReference type="KEGG" id="mxa:MXAN_2579"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509795_0_0_7"/>
    <dbReference type="OMA" id="RYYAFDW"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <end position="544"/>
        </location>
    </feature>
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        <location>
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            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="474"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="544" mass="57783" checksum="B0E9E397F32E0192" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9F7</accession>
    <name>Q1D9F7_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552568.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2497"/>
    <dbReference type="EnsemblBacteria" id="ABF86770">
        <property type="protein sequence ID" value="ABF86770"/>
        <property type="gene ID" value="MXAN_2497"/>
    </dbReference>
    <dbReference type="GeneID" id="41359875"/>
    <dbReference type="KEGG" id="mxa:MXAN_2497"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_2_1_7"/>
    <dbReference type="OMA" id="LSVNHTQ"/>
    <dbReference type="OrthoDB" id="1544298at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26074" checksum="E84CC88A6143F36C" modified="2006-07-11" version="1">MRTASGAQLDFGRLALLALMLGVGWYFWDSPALWPMKVLVVMMHESGHALATLLVGGSVDRIHLAANESGSCLSRLPPGLFAKVAVYSGGYLGSAVAGAGLMLATFRFRLRRWVLGTASVWLTVMGLVYAGDGFTLLFCLGTAVVLALGAKFLPDGVVDALNLFIAAFTALYALFDLRSDLWNSAVRSQSDAALLADLTYVPAVVWAALWSLIAIGLLAVAAYTSLHARPKGLQMPSITARARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9F8</accession>
    <name>Q1D9F8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2496"/>
    <dbReference type="EnsemblBacteria" id="ABF88954">
        <property type="protein sequence ID" value="ABF88954"/>
        <property type="gene ID" value="MXAN_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2496"/>
    <dbReference type="HOGENOM" id="CLU_111046_0_0_7"/>
    <dbReference type="OMA" id="CLEPRED"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011755">
        <property type="entry name" value="CHP02269_MYXXA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09533">
        <property type="entry name" value="DUF2380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02269">
        <property type="entry name" value="TIGR02269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188343" evidence="2">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="24793" checksum="313E2CF6E654CB80" modified="2006-07-11" version="1">MMRTFLVSAFSVLALSFLGCSNAARMPAPEAWESAEEMCTTADDAHCGSLLCHGDACGLYRCEDVPGAVELARFPPARPPAAAAAPGRGPRRNWGGGQNLPRGAVMVFPNWNGAAGWVVPPSRGLTAGRWEKHHIFPQARDLAEWFRDRGLRIHDYTLPIPRDIHQRIHKGGESGGAWNRAWREFRLRNENASPEEIFKHAGELIYRFQLMGGPIRAYHSKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Q0</accession>
    <name>Q1D9Q0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:dicarboxylate symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2403</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552478.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2403"/>
    <dbReference type="EnsemblBacteria" id="ABF92888">
        <property type="protein sequence ID" value="ABF92888"/>
        <property type="gene ID" value="MXAN_2403"/>
    </dbReference>
    <dbReference type="GeneID" id="41359787"/>
    <dbReference type="KEGG" id="mxa:MXAN_2403"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_7"/>
    <dbReference type="OMA" id="GHGMNVD"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="43812" checksum="118B3B5C23DCCF48" modified="2006-07-11" version="1">MKAHQKMLVGIASGAVAGLVANVVAGGAPWLAFVVDNVASPVGQIFIRLLLMLVVPLLFSAIVVAVAELDLKQVGRLGARTLGYTVVLSSISVLIGLVLVNTLEPGAGLSDEARALAQGGMTIQAAAAPGASSFGAVLVSMVPTNPIKAAADGDFIGLIVFSLIFGMGVALTPSEPVQRLRESIQGLYDVMMKLIDGVLSLAPFGVAALLFAMTARLGFGIFVQLASYMGTVLLALGLHMFVVYSLSVRFLGGRSPIEFFRSSRLAIVTAFSTSSSSATLPTALKVAEEHLKLPRSVSRFVLTAGSAMNQNGTALFEGVTVLFLAQVYGVPLSLSDQALIMFICILAGIGTAGVPAGSIPVIAMILGMFKIPVEGLGLILGVDRFLDMCRTTLNVTGDLAAAVYVARGESADSPAEEGAVDPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9R1</accession>
    <name>Q1D9R1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552467.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2392"/>
    <dbReference type="EnsemblBacteria" id="ABF90130">
        <property type="protein sequence ID" value="ABF90130"/>
        <property type="gene ID" value="MXAN_2392"/>
    </dbReference>
    <dbReference type="GeneID" id="41359777"/>
    <dbReference type="KEGG" id="mxa:MXAN_2392"/>
    <dbReference type="HOGENOM" id="CLU_1641886_0_0_7"/>
    <dbReference type="OMA" id="TRMAVMM"/>
    <dbReference type="OrthoDB" id="1936701at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188353" evidence="1">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="161" mass="18455" checksum="B171CBEBCB92184A" modified="2006-07-11" version="1">MRTRVRTRMAVMMLALLPWVAVAAPTGREARVEERMERAEQRHRLRQVLELSDVLDLDNAQALKLEETLQRFDERRRPLRKQVREAARILHRAARGDSEALAQVDAAALGAFEARERIAALDKELYLALAKSLPQEKRARLALALARSEGRQKMKREPGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA21</accession>
    <name>Q1DA21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552357.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2281"/>
    <dbReference type="EnsemblBacteria" id="ABF92944">
        <property type="protein sequence ID" value="ABF92944"/>
        <property type="gene ID" value="MXAN_2281"/>
    </dbReference>
    <dbReference type="GeneID" id="41359668"/>
    <dbReference type="KEGG" id="mxa:MXAN_2281"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_7"/>
    <dbReference type="OMA" id="LFNGKYD"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="23412" checksum="869A3B280CFF88CE" modified="2006-07-11" version="1">MLEKLMPKSDEFFDDFDAQCAVTVEGAKMLYELLSDYRDVGPRVQALKDAEHRGDEVTHTAFNRLHKQFITPFDRGQIHTLLSRIDDVLDLTNAAAARLHYYEIPASLPDATELARLLVLSTQKVQEVVAALRLIKKPEQILAGCKEIKRLETQADEALRSGVGRLFKSGADTLLIIKWKEIYDFIETATDKCQSVANVIEGVVLEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA81</accession>
    <name>Q1DA81_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase, M27 (PrtB) family</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552297.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2221"/>
    <dbReference type="MEROPS" id="M57.001"/>
    <dbReference type="EnsemblBacteria" id="ABF86961">
        <property type="protein sequence ID" value="ABF86961"/>
        <property type="gene ID" value="MXAN_2221"/>
    </dbReference>
    <dbReference type="GeneID" id="41359608"/>
    <dbReference type="KEGG" id="mxa:MXAN_2221"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052330_0_0_7"/>
    <dbReference type="OMA" id="FNPSISC"/>
    <dbReference type="OrthoDB" id="1415414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="26324" checksum="069E4A905759F836" modified="2006-07-11" version="1">MFKRAAVLMLNCGALLSGCGPDSHTGNAELLSNLTEAGFRPDDITVVDDAVYVGGDAHVTLAASREMLQRGEGSKEHYMTTNIVGSSVTRICVNPTTEFRSYVRLIQGLDMALANYNALGLRITFVRGPATGCTANITAKTMAGSGHVAGFPSGGLPYGAISIGTGLNSYGVDLNEHVITHALGHTLGLRHTDHFNPSISCGSGAMEPTGTGALHIPGTPTGATPGGSIMNTCYPSGTDGEFTPSDIVALNFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAB9</accession>
    <name>Q1DAB9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2182"/>
    <dbReference type="EnsemblBacteria" id="ABF86926">
        <property type="protein sequence ID" value="ABF86926"/>
        <property type="gene ID" value="MXAN_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2182"/>
    <dbReference type="HOGENOM" id="CLU_496802_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="548" mass="57462" checksum="025FDF0C430467A4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAM1</accession>
    <name>PNP_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">MXAN_2073</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552157.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAM1"/>
    <dbReference type="SMR" id="Q1DAM1"/>
    <dbReference type="STRING" id="246197.MXAN_2073"/>
    <dbReference type="EnsemblBacteria" id="ABF92645">
        <property type="protein sequence ID" value="ABF92645"/>
        <property type="gene ID" value="MXAN_2073"/>
    </dbReference>
    <dbReference type="GeneID" id="41359481"/>
    <dbReference type="KEGG" id="mxa:MXAN_2073"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_7"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329728" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="722" mass="77796" checksum="697ACF508B818963" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBN7</accession>
    <name>Q1DBN7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551795.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1684"/>
    <dbReference type="EnsemblBacteria" id="ABF91204">
        <property type="protein sequence ID" value="ABF91204"/>
        <property type="gene ID" value="MXAN_1684"/>
    </dbReference>
    <dbReference type="GeneID" id="41359123"/>
    <dbReference type="KEGG" id="mxa:MXAN_1684"/>
    <dbReference type="eggNOG" id="COG5649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111570_0_0_7"/>
    <dbReference type="OMA" id="RYFHIHE"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="2">
        <location>
            <begin position="94"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="21017" checksum="4150E5EC5774CAB1" modified="2006-07-11" version="1">MAVKSSKVAKKATARPSTSKAARPSKAVAKSAAPKSKKATAKKSAAAPKATAARRKSPAAAAEPVLLSGGNPQIAKGYGDAPIRAYIKAMPGWKRDVGHRLDELIERTVPGVSKAVKWNSPMYGVEGQGWFLSVHCFTKYIKVAFFRGTSLRPIPPGASKSRDTRYLDIREDEPLDEAQFAAWVKQASRLPGERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBP3</accession>
    <name>Q1DBP3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551789.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1678"/>
    <dbReference type="EnsemblBacteria" id="ABF87240">
        <property type="protein sequence ID" value="ABF87240"/>
        <property type="gene ID" value="MXAN_1678"/>
    </dbReference>
    <dbReference type="GeneID" id="41359117"/>
    <dbReference type="KEGG" id="mxa:MXAN_1678"/>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057081_0_0_7"/>
    <dbReference type="OMA" id="RFWHEYF"/>
    <dbReference type="OrthoDB" id="589228at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="37963" checksum="BFABA53C38AC011E" modified="2006-07-11" version="1">MSSSELPVLKFVLTNYKNFNARATRDALLSYWEHVSNGGRMFWSVAGAMSSAQLGITLAPAIRAGLIHGLSVTGANIEESLFRLVAHTGYKDFPEYRYFTKQDDTRILEQRMRRVTDTSIPEDEAFRAVEKIAVPMWKGATEKGERRFWHEYFYAFIQALDPSVYEGDPEACWLLEAARLRLPIVVPGYEDSTFGNIFASYVKAGDFNASIVKSGIEYMADFYDRYEEMSEGRGVGFFQIGGGIAGDFPICVVPSIKYDLQKPVKPWAYFCQISDSTTSYGSYSGATPNEKITWDKLTETTPMFVIESDATIVAPLILSALLECKSNPEAANALIAKHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC08</accession>
    <name>Q1DC08_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="6">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ahpD</name>
        <name evidence="8" type="ORF">MXAN_1563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AhpD family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551674.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1563"/>
    <dbReference type="PeroxiBase" id="4641">
        <property type="entry name" value="MxAhpD"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90463">
        <property type="protein sequence ID" value="ABF90463"/>
        <property type="gene ID" value="MXAN_1563"/>
    </dbReference>
    <dbReference type="GeneID" id="41359008"/>
    <dbReference type="KEGG" id="mxa:MXAN_1563"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105328_0_0_7"/>
    <dbReference type="OMA" id="AIMAMNN"/>
    <dbReference type="OrthoDB" id="1427837at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="7">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="18943" checksum="86B0739278EB7BC6" modified="2006-07-11" version="1">MASLEVVRSELADSHKDTRLNLQGVLEGGSLTAEQRWGVAVACAFAARNERLKEAMLNEAKKALANPEPVIEDARAAASLMAMNNVYYRFRHMIGKESYSTKRAGLRMNRLAQVLTNKVDFELVCLAVSAINGCEMCMQSHEKVVLDGGLSEDQVHDAVRIASVIHAAAVGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB2</accession>
    <name>Q1DCB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551570.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1454"/>
    <dbReference type="EnsemblBacteria" id="ABF93145">
        <property type="protein sequence ID" value="ABF93145"/>
        <property type="gene ID" value="MXAN_1454"/>
    </dbReference>
    <dbReference type="GeneID" id="41358900"/>
    <dbReference type="KEGG" id="mxa:MXAN_1454"/>
    <dbReference type="eggNOG" id="ENOG50320NJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106677_0_0_7"/>
    <dbReference type="OMA" id="WFLPRAK"/>
    <dbReference type="OrthoDB" id="1229930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21561" checksum="0342613069836433" modified="2006-07-11" version="1">MARSFSMRGVQSAADRAVQHARAWMLETEPGSRVHDVQLDPRFQHRGVDLLWELPSGEVRGIEVKGDRNATRRRYFFELVSNLEKDTPGCFLYSGADLLVYVFLSQGELHVVPMKAAREWFLPRAKEYPLKHAFTQTGAIRYTTVGAVVSVRDVAEGVPGVLRVPLKRRGGAKDVEEEVPPTSESPQGQESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCH3</accession>
    <name>Q1DCH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF93005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="618" mass="68440" checksum="2251AD7E3C8E86AE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI9</accession>
    <name>Q1DCI9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">MXAN_1377</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="29297" checksum="9DC1AF39AE5B1AB2" modified="2006-07-11" version="1">MPSPTDDLAVDARGLQKRFGGFSALNGLDLQIPRGAFYAYLGPNGAGKSTSIALLTGVYGPDAGSIRMLGVDAVARPMEVKRRVGVVPEELSLFERLTGRQYLTFCARMYGLDGDEAAARATELLELTELTYKAGALVAEYSKGMRRRLAIAAALIHAPELVLLDEPFEGIDVLAAGVIRELLRELSRRGVTLLLTTHVLEIAERLATHAGIIRGGRMLDQGPVGSLLSRYECPSLEAVFEKLISVPASRNARLSFYGEAPASVTPLRQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCN3</accession>
    <name>Q1DCN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF86824">
        <property type="protein sequence ID" value="ABF86824"/>
        <property type="gene ID" value="MXAN_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1333"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="AGTNEVY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="561" mass="59954" checksum="F6D5E814DEBE67FF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD06</accession>
    <name>Q1DD06_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1208"/>
    <dbReference type="REBASE" id="13888">
        <property type="entry name" value="M.MxaDKORF1208P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85941">
        <property type="protein sequence ID" value="ABF85941"/>
        <property type="gene ID" value="MXAN_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1208"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="GRWPANV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF85941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="45574" checksum="126EB760C1A9CEBD" modified="2006-07-11" version="1">MSHSQNPHAFTVHEQQATHQPCGALRWRCRAGGRGSRARQRRRHCHRPTGRNRLHGSRVGQRQGRARRVDCVALRRDARSSAGAQARGHALVWALPRTSHWTATALEDAGFEIRDVVTHLFGTGFPKSLNVSKALDAAAGAQRRVVGPGKYANRGRRSDNQVYSSGTPSHLEVETLPATDAAREWEGWGTALKPAAEHWILCRKPLGGTVAANVQRWRTGALNVAACRTPHADPTDLAESKARNPGRPDTVTSAVYGTGRPQQRVDESGRWPANVTLDESAAELLDGQATNGGASRFFYIAKPTRTERDTGCAHLPFRTGAEACGRKEGSAGMNSPRAGANSGGGRNHHPTVKSLALMRWLCRLITPPGGTVLDLFAGSGSTGVAALAEGFDFIGIEREPAYAEIAHARLCHAIEPLPKSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD13</accession>
    <name>Q1DD13_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551320.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1201"/>
    <dbReference type="EnsemblBacteria" id="ABF92992">
        <property type="protein sequence ID" value="ABF92992"/>
        <property type="gene ID" value="MXAN_1201"/>
    </dbReference>
    <dbReference type="GeneID" id="41358651"/>
    <dbReference type="KEGG" id="mxa:MXAN_1201"/>
    <dbReference type="HOGENOM" id="CLU_1452993_0_0_7"/>
    <dbReference type="OMA" id="HHNVWDA"/>
    <dbReference type="OrthoDB" id="1401580at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="20134" checksum="76144A8C7386CF6D" modified="2006-07-11" version="1">MPTTRNLLVALDPGLRECGVAVFDLDSGELLAAGMPTNPERKARGLATWSRMAGGVAEFVSTFLEPLRAAGVAVSVTVACECPQVYTAGKSKGDPNDLIELAGVVGRVAGELRATSERSFLPREWKGTLDGDVMVERIKARLGERPHEHLRVQLPRAQDKHHNVWDAVGIGLHVVGRLAPRKVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD42</accession>
    <name>Q1DD42_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551291.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1171"/>
    <dbReference type="EnsemblBacteria" id="ABF92295">
        <property type="protein sequence ID" value="ABF92295"/>
        <property type="gene ID" value="MXAN_1171"/>
    </dbReference>
    <dbReference type="GeneID" id="41358622"/>
    <dbReference type="KEGG" id="mxa:MXAN_1171"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008901_0_0_7"/>
    <dbReference type="OMA" id="CFLKDYA"/>
    <dbReference type="OrthoDB" id="983098at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="58645" checksum="84D790F98E63DB0A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD49</accession>
    <name>Q1DD49_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1164"/>
    <dbReference type="EnsemblBacteria" id="ABF89169">
        <property type="protein sequence ID" value="ABF89169"/>
        <property type="gene ID" value="MXAN_1164"/>
    </dbReference>
    <dbReference type="GeneID" id="41358615"/>
    <dbReference type="KEGG" id="mxa:MXAN_1164"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1388927_0_0_7"/>
    <dbReference type="OMA" id="ERQGTQS"/>
    <dbReference type="OrthoDB" id="1155654at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="21769" checksum="A037F36F97767A21" modified="2006-07-11" version="1">MIEAFSKVSEASKLLLEKGLGPSTGMEALRMVGHALGVDRAYILENRVQGTYGRFITDMRHAWAEPPTPSPLANPVMRAFSFREFAPGWVDMLEAGMVVACPTRDAPPTIKDLLERQGTQSILLCPINPSRQQWWGMVAFEDCRRPRAWKPEEVTLLKSLARAVAASVRHGQMRSSLDQVRNSLRQAVSRTPVSGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE5</accession>
    <name>DTD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">MXAN_1068</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551188.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDE5"/>
    <dbReference type="SMR" id="Q1DDE5"/>
    <dbReference type="STRING" id="246197.MXAN_1068"/>
    <dbReference type="EnsemblBacteria" id="ABF86443">
        <property type="protein sequence ID" value="ABF86443"/>
        <property type="gene ID" value="MXAN_1068"/>
    </dbReference>
    <dbReference type="GeneID" id="41358520"/>
    <dbReference type="KEGG" id="mxa:MXAN_1068"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_7"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000259292" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="153" mass="16370" checksum="D6E2441DA1D15EB3" modified="2006-07-11" version="1">MRAVVQRVLEASVTVEGQRVSDIGPGLLVLLGVGKGDTEADVAWMVEKLATLRIFEDAAGKMNLSLEETSRQLIVVSQFTLYGDARKGRRPSFIDAMEPVSAKALYERTCELLRQRGLSVGTGIFAADMKVALVNDGPVTLLLESPGPAAPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDG0</accession>
    <name>Q1DDG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551173.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1052"/>
    <dbReference type="EnsemblBacteria" id="ABF87231">
        <property type="protein sequence ID" value="ABF87231"/>
        <property type="gene ID" value="MXAN_1052"/>
    </dbReference>
    <dbReference type="GeneID" id="41358505"/>
    <dbReference type="KEGG" id="mxa:MXAN_1052"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328956_0_0_7"/>
    <dbReference type="OMA" id="RHPSDYL"/>
    <dbReference type="OrthoDB" id="370538at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="852"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="889" mass="93924" checksum="F2F885C83CC151FE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM1</accession>
    <name>Q1DDM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551112.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0991"/>
    <dbReference type="EnsemblBacteria" id="ABF88644">
        <property type="protein sequence ID" value="ABF88644"/>
        <property type="gene ID" value="MXAN_0991"/>
    </dbReference>
    <dbReference type="GeneID" id="41358447"/>
    <dbReference type="KEGG" id="mxa:MXAN_0991"/>
    <dbReference type="HOGENOM" id="CLU_1883513_0_0_7"/>
    <dbReference type="OMA" id="CCGELAV"/>
    <dbReference type="OrthoDB" id="1957212at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="14372" checksum="808F2510E87603A1" modified="2006-07-11" version="1">MLVRVLTVLVVLGLPPIAGAVEGLFHFCQGTVKLDLTCVCPQSKRTKAAPDTQEAGIRGNHHDCCGELAVQLPAPEPVTASSRHAWALTPLAVLPQAVPVVPPAPEALPTSWVRIRGVHHATAPPLYLQHCSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDN1</accession>
    <name>Q1DDN1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding protein, Rieske family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551102.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0981"/>
    <dbReference type="EnsemblBacteria" id="ABF86853">
        <property type="protein sequence ID" value="ABF86853"/>
        <property type="gene ID" value="MXAN_0981"/>
    </dbReference>
    <dbReference type="GeneID" id="41358437"/>
    <dbReference type="KEGG" id="mxa:MXAN_0981"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_1_0_7"/>
    <dbReference type="OMA" id="DRCPHRN"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="363" mass="40024" checksum="4F37477991D3A5E8" modified="2006-07-11" version="1">MSSREEGRTSGTPAGHISVVHLPNAWFILCASSELGDKPLARTLQGSPLVLFRGEGGKPAALVDRCPHRNVPLSLGRVKEGQLQCGYHGWRFDGAGQCRAIPGFLGEPGARARCATAHATREQDGFVWVYSTPGVEPTTEPYRFPLLEAREYTTVRRTLRAPGSLHSTLENTLDVPHTAYLHGGLFRTEEKRNEIDVVVRRSADKVEAEYIGEPRPSGLVGRLLAPGGGVVQHFDRFLMPSIAQVEYRIGDTSHIMVTSAMTPVSDWDTLVYAVVTFRLPLPRWLVRAALPLLMPVALHIFGQDARILRQQTETIRRFGTEAYASTEIDVLGPGILRLLRAAEREKPGAVGDAVHETRLKMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE08</accession>
    <name>Q1DE08_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chalcone_isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550975.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0854"/>
    <dbReference type="EnsemblBacteria" id="ABF92052">
        <property type="protein sequence ID" value="ABF92052"/>
        <property type="gene ID" value="MXAN_0854"/>
    </dbReference>
    <dbReference type="GeneID" id="41358313"/>
    <dbReference type="KEGG" id="mxa:MXAN_0854"/>
    <dbReference type="HOGENOM" id="CLU_102167_0_0_7"/>
    <dbReference type="OMA" id="VYVWSLY"/>
    <dbReference type="OrthoDB" id="1954032at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16036">
        <property type="entry name" value="Chalcone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="SSF54626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188191" description="Chalcone_isomerase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone_isomerase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="20366" checksum="4DCF119385F26F34" modified="2006-07-11" version="1">MRTQAWGGNLRCLVAGMLLVAGAAQAGQKQVGGVHMPVSLNLKGRTVELAHMELHKQLFFKVYVWSLYMEDRPRSTHEAINSNSVKRLHFHFLRNISRDQLVGSFRDGLEHSPALRRGPLANHLRIMLASLKDVQKGEDLVITYTPGVGLEVGGDASGGVFIPGKNFADALFSVWLDSHPIFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA0</accession>
    <name>Q1DEA0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550883.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0756"/>
    <dbReference type="EnsemblBacteria" id="ABF90575">
        <property type="protein sequence ID" value="ABF90575"/>
        <property type="gene ID" value="MXAN_0756"/>
    </dbReference>
    <dbReference type="GeneID" id="41358226"/>
    <dbReference type="KEGG" id="mxa:MXAN_0756"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489025_0_0_7"/>
    <dbReference type="OrthoDB" id="1806893at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188547" evidence="2">
        <location>
            <begin position="29"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="559" mass="52003" checksum="3E94BF82FAB943D6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEG1</accession>
    <name>Q1DEG1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0694</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550822.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0694"/>
    <dbReference type="EnsemblBacteria" id="ABF90550">
        <property type="protein sequence ID" value="ABF90550"/>
        <property type="gene ID" value="MXAN_0694"/>
    </dbReference>
    <dbReference type="GeneID" id="41358167"/>
    <dbReference type="KEGG" id="mxa:MXAN_0694"/>
    <dbReference type="HOGENOM" id="CLU_165462_0_0_7"/>
    <dbReference type="OMA" id="MRRLWTI"/>
    <dbReference type="OrthoDB" id="2154475at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLH55567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13076" checksum="7D9817CF62DCD16E" modified="2006-07-11" version="1">MRRLWTIKTPGQVRREDLDGSQTKTTPPEVRMDDSKKGSRRTIRALASPAALTVLFGAFASNAATLKPVVNDTIGVSNVSFPTTEVQQQQQQQQQQVVKPGTMASGKPVMLQSLVADLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ7</accession>
    <name>Q1DEJ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550789.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0658"/>
    <dbReference type="EnsemblBacteria" id="ABF92430">
        <property type="protein sequence ID" value="ABF92430"/>
        <property type="gene ID" value="MXAN_0658"/>
    </dbReference>
    <dbReference type="GeneID" id="41358133"/>
    <dbReference type="KEGG" id="mxa:MXAN_0658"/>
    <dbReference type="HOGENOM" id="CLU_1480528_0_0_7"/>
    <dbReference type="OMA" id="HERFGED"/>
    <dbReference type="OrthoDB" id="1169199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="21337" checksum="EAB183E9A7ADA7F3" modified="2006-07-11" version="1">MTASLSGVNYKGFTVQNLLAYVHERFGEDTARTAVESLLPELQPHADPRTTLAVGWVPVETYFGIIQHVVDRHFDGKPEGAHTVGYEVTLRDIHSIFKMVLRFTTPNMVLGMARRMWRSYCDQGELLHQEENGTGMLLLRQFTYQTPVALHEMAGGFRAYLECSSAKNPRVEIVAPDKDGTLRWRIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEK2</accession>
    <name>Q1DEK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S8A (Subtilisin) subfamily</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
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        <property type="protein sequence ID" value="ABF91759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0653"/>
    <dbReference type="EnsemblBacteria" id="ABF91759">
        <property type="protein sequence ID" value="ABF91759"/>
        <property type="gene ID" value="MXAN_0653"/>
    </dbReference>
    <dbReference type="GeneID" id="41358128"/>
    <dbReference type="KEGG" id="mxa:MXAN_0653"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_037733_0_0_7"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07473">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P_dom"/>
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    </dbReference>
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        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="P/Homo B" evidence="5">
        <location>
            <begin position="170"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="611" mass="63375" checksum="19BD50CA99D5480C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEV3</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="gene ID" value="MXAN_0551"/>
    </dbReference>
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    <dbReference type="OMA" id="WAATRTI"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="413" mass="43890" checksum="FC963151D80FF862" modified="2006-07-11" version="1">MDPLTGPGAMTPESLHRSAAPAPGRRVPKALAWLASAALLVGGVALLSSRGGDGASSDAEAGGTAAAAREAASGGRGHGGRAGAGGTHDEEPPPPRFDEAVCWRELERFDAAVTLENFRAWAAPLLASGDSLVADYLAGRLTELIGQDPGRASEVLSWARTAGPDEFDVLLTALRGSEAVHHAQVATRLLAQGLDATLDGGRRAGLLAALDTQKRFEPAALNTLTSFAKDPVSGEAGWAATRTIARVMKRDFEAKGNAAPYMDALLTIGTESPDEQIRYLALSTPMHATPVLDERTRAQYAKVLTQEGSPDGREAAAHNLSISGDNQQVLELFAQAFAREQETCVRWALFRFAARASGREALPVMANMAMTDPRFQPIYQIFEQLYASGLHDFVRLWNSLPDQDPFGCLVGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF78</accession>
    <name>Q1DF78_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0425</name>
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    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF91145">
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        <property type="gene ID" value="MXAN_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0425"/>
    <dbReference type="HOGENOM" id="CLU_1433114_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20464" checksum="9CE61E35926705DE" modified="2006-07-11" version="1">MERGMDGQDFPRLPTWCRALLVRGQEGIDATFQALLKEREHHCHTQAKSFMPRDEESETEPFIFVGAWRSCIWPSVAGSRRSPTISSCPASPVRAETLVCHHAHGQPGHSRIPSCQTPRRVPSLDLGGIQRRHGAVPGLPTPGRGALRPGVGEGVPGSIARSGFLMSDRPAGPPSGPTGSRRQMRLAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG0</accession>
    <name>Q1DFG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550477.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89393">
        <property type="protein sequence ID" value="ABF89393"/>
        <property type="gene ID" value="MXAN_0339"/>
    </dbReference>
    <dbReference type="GeneID" id="41357837"/>
    <dbReference type="KEGG" id="mxa:MXAN_0339"/>
    <dbReference type="eggNOG" id="ENOG5031JIF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516321_0_0_7"/>
    <dbReference type="OMA" id="RDCTYRL"/>
    <dbReference type="OrthoDB" id="1587968at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188504" evidence="1">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="181" mass="19497" checksum="74A1760454FF6EAE" modified="2006-07-11" version="1">MKRMLMPLRRSVLVLGVVLGASVAMAERKQDAINMKIAYQSFNLEMTPEAVSGADFQVARSPGMLKGRGLKGNFALTLKDGAVEGAVGGAPVNLTVTKEGDAIVAKGGFGGRPVNLKLSPSELTIYVRDCTYRLKAANTNRFYTGRRSCDRAMTPDSEIWLPDEFLAASPEEKAAILFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFQ5</accession>
    <name>Q1DFQ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550382.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90918">
        <property type="protein sequence ID" value="ABF90918"/>
        <property type="gene ID" value="MXAN_0237"/>
    </dbReference>
    <dbReference type="GeneID" id="41357738"/>
    <dbReference type="KEGG" id="mxa:MXAN_0237"/>
    <dbReference type="HOGENOM" id="CLU_645143_0_0_7"/>
    <dbReference type="OMA" id="MATHPDN"/>
    <dbReference type="OrthoDB" id="824819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="49211" checksum="66ADA95BD3C815B0" modified="2006-07-11" version="1">MPSYGEGMATHPDNLRARLEDRADLLEATRLRYRALRGMLASFFWKQRVRSQFELLLEVARTQPEVDATLAALKRRAAAEGWPANAAPMKLMREVERLREDVRRVAFKRLPAEGRPATLGEALLKLEETVLEAGPLLGRHIWARAVELLPRNLPELRAACAAAEVFEHVFKRPAPEGVLPFTVEEAEALQRALPLAETALAALWQRLEHFDTRGQVKGFLQARVSRAPQRVPRSGPELLLHVAFWRGVAWARLRASLGERLAPVVPADAEVPALLVWLAAREGRFERGAEPRMGGPGLFAPEAPGPQPRTDGAVGLRGVGVEVAGEVRLPACEAFGEGRAGLFELAAQLAALSRERPVGTWDEETAWARLWNAAQRARGEQGEDVERLRDALRLFILLRGQGQTPARLFSPERARVPTVEIGADAGAAVKDLPALVHAARAAAWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFU9</accession>
    <name>Q1DFU9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90794">
        <property type="protein sequence ID" value="ABF90794"/>
        <property type="gene ID" value="MXAN_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0192"/>
    <dbReference type="HOGENOM" id="CLU_172515_0_0_7"/>
    <dbReference type="OMA" id="TRKTARG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="12446" checksum="4D20AAD1780FFF89" modified="2006-07-11" version="1">MAEHEGQQTPRTKVRRRRTPTPKAVRTGERNAGPDWGSIALRRTASEYRATAEEQAARVREEIEAALVQARSTREAIEQRIADQLHAPPVRHPPPPRRKRATRASRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG37</accession>
    <name>Q1DG37_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0103"/>
    <dbReference type="EnsemblBacteria" id="ABF88349">
        <property type="protein sequence ID" value="ABF88349"/>
        <property type="gene ID" value="MXAN_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0103"/>
    <dbReference type="HOGENOM" id="CLU_142202_0_0_7"/>
    <dbReference type="OMA" id="QVRCSGS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="16498" checksum="6746021405C342B6" modified="2006-07-11" version="1">MGALGFPRHPLEHGVARVTRVAAQLTGLVCDGVCLARLGQSLVRGRTFMMKQGKRVPGLKWVIAAFILAGCRGAEGEVPTETESRLSLKEGQVLGPACTGEQKQCPEGLSCASFNLGSGPEIRCVQSPEICDLFKCSSGECVVLESHPIQVRCSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG87</accession>
    <name>Q1DG87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550202.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90175">
        <property type="protein sequence ID" value="ABF90175"/>
        <property type="gene ID" value="MXAN_0053"/>
    </dbReference>
    <dbReference type="GeneID" id="41357562"/>
    <dbReference type="KEGG" id="mxa:MXAN_0053"/>
    <dbReference type="eggNOG" id="ENOG5032XT1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530915_0_0_7"/>
    <dbReference type="OMA" id="WHFMAPP"/>
    <dbReference type="OrthoDB" id="1452495at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="207" mass="23241" checksum="CC9DA0F384BFA064" modified="2006-07-11" version="1">MSTSPHPFGTRTAGARLSARAPPPVHAVPSHKDTAMGDPRNPKRAHERWNLERLRACEAEVRALAPWVTVSGGWAWHFMAPPHEELKRFHDHKDVDLFVEPARFPELIAVLTARGYHRIWTRFDATSTHFYRYARHDEGGKVLLDVFVRRVPSVDAGGIRVVDPATLLTFYGDIHSTDDCVSVLAARRLLAKGHSPLGRVELVTQAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VQZ3</accession>
    <accession>Q1CXR7</accession>
    <name>Y6689_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_6689</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="J. Bacteriol." volume="184" first="1462" last="1465">
            <title>Mapping of Myxococcus xanthus social motility dsp mutations to the dif genes.</title>
            <authorList>
                <person name="Lancero H."/>
                <person name="Brofft J.E."/>
                <person name="Downard J."/>
                <person name="Birren B.W."/>
                <person name="Nusbaum C."/>
                <person name="Naylor J."/>
                <person name="Shi W."/>
                <person name="Shimkets L.J."/>
            </authorList>
            <dbReference type="PubMed" id="11844780"/>
            <dbReference type="DOI" id="10.1128/JB.184.5.1462-1465.2002"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LarC family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF89710" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AF449411">
        <property type="protein sequence ID" value="AAL56586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89710.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8VQZ3"/>
    <dbReference type="SMR" id="Q8VQZ3"/>
    <dbReference type="STRING" id="246197.MXAN_6689"/>
    <dbReference type="EnsemblBacteria" id="ABF89710">
        <property type="protein sequence ID" value="ABF89710"/>
        <property type="gene ID" value="MXAN_6689"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6689"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000146849" description="Putative nickel insertion protein">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="390" mass="41860" checksum="4B78D6AD4A7642F7" modified="2002-03-01" version="1">MRRILYLEPVGGIAGDMFLAAGLDLGISPAELERALSGLRVPGWKLAVSRAVRHAISGTHLDVVLDAREAHPHRAYADIRRLIEEADTLPPRAKERALAVFRAIGEAEAKVHGVSIDDIHFHEVGAVDSIVDICGAAVVLELLGNPEVHAAPPPLGSGTIRVAHGAMPIPVPATLELLRDVPVRFEGVGELTTPTGAALLKVLAHIGHPPDFIVEKVGYGVGTKDFKDRPNVLRASLGRLEQASNEGLWVVEANLDDATPQLLGHLLERLLAVGALDAWVTPVVMKKSRPGHLLSALVEGGTREAIVDVVLRESTTLGVRYHRVERQALERDWVEVETPWGKVRVKRGLRQGAVLNAHPEFEDCRQVAEAAGVPVKQVMAAAVAALGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ0</accession>
    <name>Q1CVZ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding monooxygenase, PheA/TfdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557239.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7320"/>
    <dbReference type="EnsemblBacteria" id="ABF87382">
        <property type="protein sequence ID" value="ABF87382"/>
        <property type="gene ID" value="MXAN_7320"/>
    </dbReference>
    <dbReference type="GeneID" id="41364483"/>
    <dbReference type="KEGG" id="mxa:MXAN_7320"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_2_7"/>
    <dbReference type="OMA" id="PPFVGQG"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="58266" checksum="135885C556BB8780" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ2</accession>
    <name>Q1CVZ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase, Slt family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7318"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88670">
        <property type="protein sequence ID" value="ABF88670"/>
        <property type="gene ID" value="MXAN_7318"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7318"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513604_0_0_7"/>
    <dbReference type="OMA" id="VWMFIPE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="181"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="398"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="535" mass="57115" checksum="10968107F7698965" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ5</accession>
    <name>Q1CVZ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557234.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7315"/>
    <dbReference type="ESTHER" id="myxxd-q1cvz5">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90715">
        <property type="protein sequence ID" value="ABF90715"/>
        <property type="gene ID" value="MXAN_7315"/>
    </dbReference>
    <dbReference type="GeneID" id="41364478"/>
    <dbReference type="KEGG" id="mxa:MXAN_7315"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_7"/>
    <dbReference type="OMA" id="ERWAKND"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29110" checksum="A6ACE83BE395D5B6" modified="2006-07-11" version="1">MPLLQLEELSLYFEESGEGTPVLFLHGLGSSGRDWESVAPRLTGRHRVIVPDARGHGRSGKPPGAYGVPRFARDIAGLCDALGLTGVHVVGLSMGGMMGFQLAVDRPELVRSLVIVNSGPELVARTLRRKFEFGLRLTLLKLLGPSVLAKVLAPKLFPKPEQEALRQRALEIFSANDPDAYLRATKGLVGWSVMRHLGGITCPVLVLASDRDYTPVSTKQAYVDLLPNARLQVLSDSGHASPHDQPDKVADAVEAFLAGVEDAAADARQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF7</accession>
    <name>Q1CWF7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7153"/>
    <dbReference type="EnsemblBacteria" id="ABF88993">
        <property type="protein sequence ID" value="ABF88993"/>
        <property type="gene ID" value="MXAN_7153"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7153"/>
    <dbReference type="eggNOG" id="COG1371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_1_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="55"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19687" checksum="70AB9430AA1621AE" modified="2006-07-11" version="1">MVPPLPRRRRRGGACVNLASGHTNEGGVMETGQASAAREAMPRWEHLTRGSQRVVRGQGRSLEEAFEQAAVALCALVVDPASVEVREEVELVCEATAPERLLADWLRAIVHKMAARRLCFRCFAVRMDGTRLFGHAFGEPLDRERHPFARDVRGVSLVDTRVSQGADGLWTAECEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH3</accession>
    <name>Q1CWH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557056.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7137"/>
    <dbReference type="EnsemblBacteria" id="ABF92473">
        <property type="protein sequence ID" value="ABF92473"/>
        <property type="gene ID" value="MXAN_7137"/>
    </dbReference>
    <dbReference type="GeneID" id="41364311"/>
    <dbReference type="KEGG" id="mxa:MXAN_7137"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643769_0_0_7"/>
    <dbReference type="OMA" id="PWLIQQM"/>
    <dbReference type="OrthoDB" id="1684783at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011959">
        <property type="entry name" value="CHP02270"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02270">
        <property type="entry name" value="TIGR02270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="47490" checksum="EFEECBB8B675C764" modified="2006-07-11" version="1">MTNMLTWRPPHWSNYETHLDEAAFRLSQWEAALDAPDFILEEAAELEEQLAAHIDGLVLGGQPVAIQLLEPSLAAAEPEHITVAALSLLKGAAPSGTTAVLSALESAEPPALAALQRALGLAPFPALLSSLPALLQKDDALPELQALVLDTLGQHGVATHQQCLPWITHPVPQVAAAALRAASRSRLPLEPAHIQRAMNSASSDLRDAAIVAGLLSGHSAAWTACQAVAAPGGTGGRLPLLLLGLNGDERDLKRLLERLSDKSLQADVLWALGFSGRLDAANACVELLGQGPIAALAGEAFSAITGLRIEGDFAIPKDEQEAEEPVPLENDDLDADLKPKPEDSLPTPNAMTVTAWWQQTRPKLDARQRYLSGQPHQPQVLLDALISAPMRRRHALALDLELRSRGALRVPTRMFVAQQVEAWKKAQGAPTSTFNRPFAEALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWP0</accession>
    <name>Q1CWP0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556989.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7070"/>
    <dbReference type="EnsemblBacteria" id="ABF90030">
        <property type="protein sequence ID" value="ABF90030"/>
        <property type="gene ID" value="MXAN_7070"/>
    </dbReference>
    <dbReference type="GeneID" id="41364245"/>
    <dbReference type="KEGG" id="mxa:MXAN_7070"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008143_0_0_7"/>
    <dbReference type="OMA" id="GDLHHYA"/>
    <dbReference type="OrthoDB" id="1395551at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="611" mass="67694" checksum="89E76B33F0418E4D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWP2</accession>
    <name>Q1CWP2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556987.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7068"/>
    <dbReference type="EnsemblBacteria" id="ABF90674">
        <property type="protein sequence ID" value="ABF90674"/>
        <property type="gene ID" value="MXAN_7068"/>
    </dbReference>
    <dbReference type="GeneID" id="41364243"/>
    <dbReference type="KEGG" id="mxa:MXAN_7068"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_8_1_7"/>
    <dbReference type="OMA" id="DCSCGIG"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="29581" checksum="A0F4F9E07AD8B8F4" modified="2006-07-11" version="1">MSERRFSHGAPSMSDLALGFYEGMAEEYHLLFANWPQVVERQGAMLDALLRRCEAPPPRRVLDCACGIGTQALGLAGRGYTVHATDLSPAAVARAEREARAMNVHLTTGVADMRTLDAQVEGTFPVVLALDNAVTHLLTDEDLDAAARAMASKLASGGLVALSVRDADALVQSQPRFTSERLLDAPEGRRILFQIWDWAADGRTYTVHQFILRPEGKGWHTTEHTGVYRALQRVDLERALTRAGLMDTRWHTPEETGFHQPILTARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXB0</accession>
    <name>Q1CXB0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556771.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6846"/>
    <dbReference type="EnsemblBacteria" id="ABF89212">
        <property type="protein sequence ID" value="ABF89212"/>
        <property type="gene ID" value="MXAN_6846"/>
    </dbReference>
    <dbReference type="GeneID" id="41364035"/>
    <dbReference type="KEGG" id="mxa:MXAN_6846"/>
    <dbReference type="eggNOG" id="ENOG5031D9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959432_0_0_7"/>
    <dbReference type="OMA" id="GTHRGVQ"/>
    <dbReference type="OrthoDB" id="803323at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32973" checksum="5169BCF508932F2E" modified="2006-07-11" version="1">MLQLTIYCMNTERRKSRKWWCATLVVWGLAGTACDNVATGDVQVSMSGGDGTQRGLPDTLFQDGWSIQFTRYLVSLGDVTLTSASGETHRSSRHVLVDVQKGDIPLVELTGVPAGRWDVGFRVSPPEARTELADGQVSAEDLAMMRERGFSYFVEGHATKQGEPVLRFRMGFPVNALMNNCINGADGTQGIIVPEGSVARPEVTIHAEHMFYDRLGTHRGVQLRFEAIAATAGEDHVITPGGLATQELTDLRGRDGNELRDAQGQPVIYQPGAFDVRTLQEFITQSVVDQAHLNGGGVCTVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC2</accession>
    <name>Q1CXC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
        </source>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92961">
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        <property type="gene ID" value="MXAN_6834"/>
    </dbReference>
    <dbReference type="GeneID" id="41364023"/>
    <dbReference type="KEGG" id="mxa:MXAN_6834"/>
    <dbReference type="HOGENOM" id="CLU_478043_0_0_7"/>
    <dbReference type="OMA" id="RMDGAMR"/>
    <dbReference type="OrthoDB" id="570347at2"/>
    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="570" mass="61345" checksum="52910A504690028E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ6</accession>
    <name>Q1CXJ6_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_6760</name>
    </gene>
    <organism evidence="3 4">
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="ABF86436">
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_6760"/>
    <dbReference type="HOGENOM" id="CLU_911621_0_0_7"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="33401" checksum="A6BC55392185206D" modified="2006-07-11" version="1">MPMSSFRIPNVIDRALRSLGGGRGARRPEGPGAPGPQLQDWGPSAQPPRPGDNFRPRLPPPLHPPMGGQERAPVKSVAELVPPGLEDTPGQEALGQRFGSDAALLASHLSPPQVPGSERATRLWAFYTAYATAAARHPPQPEARQAFREALEGQGFGELRDARTGEDGVTRGLWVMEARTPAEARTRAAEVRLDPPPEVRHSEEAAARPAEQPLVQAAGARAATALHGPVMPALRPRDEASSSEDAQQDGDTQRRRGTNRRLGARMLWNVLHRFRAGPDDGAVAEGQWDRVTFGALLVLLAIALAVAALVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXQ8</accession>
    <name>Q1CXQ8_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6698</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88321">
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    </dbReference>
    <dbReference type="GeneID" id="41363891"/>
    <dbReference type="KEGG" id="mxa:MXAN_6698"/>
    <dbReference type="HOGENOM" id="CLU_535094_0_0_7"/>
    <dbReference type="OMA" id="CYEGQER"/>
    <dbReference type="OrthoDB" id="574071at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="509" mass="57586" checksum="80650B7AC28EE5EE" modified="2006-07-11" version="1">MSKIGERLPFVSTSKTQTSPTGQKDVSTQQWVDLLGSVLPTQSVTKAAPASTFATQAPGTSGTPQPPFGKEILPSALGPLRDERLAACIDKAFREVFQGERWPSGPERSKWMDFARELRNKNPEITAEEVRFAIQDKLRLERDGLDAHSPANTDRFISEAIAWVNQCYDEKAPPPTEADMQHWRAFAADLMSKNPKTTPEELKYAIIDAVRAKVTGTDAVTPENIDKFIQDAVKWVTQCYEDKEREATPAELKEWRAFAQEQLKKDPEISPEHLKYAITDAIRAKMTGTGEATPLNIDRFIEDGVKWVTQCYEGQERKPTAGELAHWRDFARKHQKANPDITPEALKFAIQDAIRVKATGMDGTGSTNIDQFIQDAVKWVSFCYEGQERDATPEEMQRWRAFANEKKKENKDISPEELKFAIQDAMRDEKMGTDAPASNRIEDHIRAAYGWLIYLNQAGPSQPSSEPTPNELHEWKKFAEKKLKETPEMTSEELRYYILDSLRTAMANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXR3</accession>
    <name>Q1CXR3_MYXXD</name>
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            <fullName evidence="3">Fibril biogenesis regulator DifD</fullName>
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    <gene>
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        <name evidence="3" type="ORF">MXAN_6693</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-2012704">
            <id>Q1CXR3</id>
        </interactant>
        <interactant intactId="EBI-2012627">
            <id>Q1CXR4</id>
            <label>difE</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ABF87390"/>
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    </dbReference>
    <dbReference type="GeneID" id="41363886"/>
    <dbReference type="KEGG" id="mxa:MXAN_6693"/>
    <dbReference type="eggNOG" id="COG2201">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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            <position position="54"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13170" checksum="4D555ED2DE21FFDF" modified="2006-07-11" version="1">MAKRVLVVDDAIFMRNMIKDIFASGGFEVVGEAANGLEAVEKYKELKPDLTTMDIVMPFKSGIEATREIIKADSSAVVIMCSALGQESLVMEAIEAGASDFIVKPFRAEDVLAVVKKVLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY63</accession>
    <name>Q1CY63_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6538"/>
    <dbReference type="EnsemblBacteria" id="ABF87605">
        <property type="protein sequence ID" value="ABF87605"/>
        <property type="gene ID" value="MXAN_6538"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6538"/>
    <dbReference type="HOGENOM" id="CLU_3330554_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="38" mass="4254" checksum="509B784E4ED88E7D" modified="2006-07-11" version="1">MMFPDENFFDEVVLNMGLLIALKVVGVVMLLVTYAHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF9</accession>
    <name>Q1CYF9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556372.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6440"/>
    <dbReference type="EnsemblBacteria" id="ABF91997">
        <property type="protein sequence ID" value="ABF91997"/>
        <property type="gene ID" value="MXAN_6440"/>
    </dbReference>
    <dbReference type="GeneID" id="41363649"/>
    <dbReference type="KEGG" id="mxa:MXAN_6440"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2057423_0_0_7"/>
    <dbReference type="OMA" id="RRCATCT"/>
    <dbReference type="OrthoDB" id="1769957at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14557" checksum="6E27F886DACD1437" modified="2006-07-11" version="1">MRATDAKWERPQKGDVMDAKRRCATCTEEVSLEVRRCPRCGARTEPMHRGVDGRLLTGVCAALGRELGVDAALIRVGFVVALAVSGGTALMVYLLLWAFTPPSATGTAPLRRTYNWLSGLGNSERTPRVERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM2</accession>
    <name>Q1CYM2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86574">
        <property type="protein sequence ID" value="ABF86574"/>
        <property type="gene ID" value="MXAN_6378"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6378"/>
    <dbReference type="HOGENOM" id="CLU_405878_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="677" mass="72900" checksum="D334783DA241E549" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYW7</accession>
    <name>Q1CYW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86789">
        <property type="protein sequence ID" value="ABF86789"/>
        <property type="gene ID" value="MXAN_6279"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6279"/>
    <dbReference type="HOGENOM" id="CLU_1288246_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187911" evidence="2">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="24795" checksum="3005BF1874884CF6" modified="2006-07-11" version="1">MNSIARAVLASSMFAASSAFAQDVEMNIHADDIGMPSTSISVEGMSPDGNAAGVNMEIRGGGARMEVNVSGTGTPPPSGRHERRERREYREEVAPRETPVRHVRHHSEPAFRDCGTNQDPGCTMQRNGHFAMDAETFHGFMQSLKSTRNELTREDMVEKVMTRAFLTAKQFGLVLDLFQNEITRLDVAKTAAPRVVNPQHALGFSSKWRNSISADEYVEIITEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYY4</accession>
    <name>Q1CYY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556202.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6260"/>
    <dbReference type="EnsemblBacteria" id="ABF92842">
        <property type="protein sequence ID" value="ABF92842"/>
        <property type="gene ID" value="MXAN_6260"/>
    </dbReference>
    <dbReference type="GeneID" id="41363483"/>
    <dbReference type="KEGG" id="mxa:MXAN_6260"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023622_1_0_7"/>
    <dbReference type="OrthoDB" id="448815at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="532" mass="58968" checksum="252B54B33D4A01AD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ09</accession>
    <name>Q1CZ09_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS630 family, truncated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556177.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6235"/>
    <dbReference type="EnsemblBacteria" id="ABF87080">
        <property type="protein sequence ID" value="ABF87080"/>
        <property type="gene ID" value="MXAN_6235"/>
    </dbReference>
    <dbReference type="GeneID" id="41363457"/>
    <dbReference type="KEGG" id="mxa:MXAN_6235"/>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_15_3_7"/>
    <dbReference type="OMA" id="WQLKCRA"/>
    <dbReference type="OrthoDB" id="1363223at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="25293" checksum="98B1540FC3D3AEF9" modified="2006-07-11" version="1">MGRALASVGARRKRPRPVVRCPWPERQRQQRLWQLKCRAVYARPEEPVCYEDEMDVHLNPKVGPDWMLPGERREVVTPGNNQKRYVAGALNSRTGELTWVKGERKTSALFIELVRAVSEANPMARRLHFILDNAATHSSKKTKKALAEMGERMVLHFLPPYCPEGNRIERVWWDVHANVTRNHRCKKMSALIAEVDAYLEARNAQQTASPLLRAGPARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ10</accession>
    <name>Q1CZ10_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556176.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6234"/>
    <dbReference type="EnsemblBacteria" id="ABF92575">
        <property type="protein sequence ID" value="ABF92575"/>
        <property type="gene ID" value="MXAN_6234"/>
    </dbReference>
    <dbReference type="GeneID" id="41363456"/>
    <dbReference type="KEGG" id="mxa:MXAN_6234"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_5_7"/>
    <dbReference type="OMA" id="DYNVLMF"/>
    <dbReference type="OrthoDB" id="1384345at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="394" mass="41394" checksum="95CCABC92314DE49" modified="2006-07-11" version="1">MKNSTRIYLLSFISFLIGTAEYIIAGILDQIAQDLNLPVPVIGQMITVFSIAFAVGTPLVITLTSSVDRKKLLIFFMLVFAAANLVTLALSDYGWLNASRAASGLSAGVVEVIALTLAATLAAPGKKAGAIAMVVIGFSAALVVGVPLGRVISGIMDWRYIFAGLGVLTLASLVLVVRAIPSTRGEAAVPLKHQLKLLKNGQISIVYVMTFFWISAFSIIYSYISPYLANVARMADGTISIMLLICGIASIIGSRLGGWFTDKSGYAPTLLAGFAVHCATLGLFFLFGQSAWIMYALLITWSLSAWSSGPALQFRLISLAPESTSIIFSCYTSMIQFGMAAGAIAGGVVIQIGSLDQLPSVGAASVLVSLVLLATVASEKARSGHKLGLPGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE3</accession>
    <name>Q1CZE3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6095"/>
    <dbReference type="EnsemblBacteria" id="ABF90479">
        <property type="protein sequence ID" value="ABF90479"/>
        <property type="gene ID" value="MXAN_6095"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6095"/>
    <dbReference type="HOGENOM" id="CLU_1265819_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="25223" checksum="EA8537FA79DA2F15" modified="2006-07-11" version="1">MTGTAWKRTVIQERFTRVTKRGWRNELRSVTARMPVNGTGEVAGVADIRACVSVQRGTRRVPDGTERVCRTKSRKVACGTEEKCRRKDMGNGFMEEVCEDVTKYCRESYEDCQNETRYRREPVYADQCTYDTHEWKPLTRREASGTDDAPRWPELAVGAADRLRREETYTVRLRYEDDGAHEHVLEPEDERTFLVWKKGQGARLTVTNLGTVEKVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZH8</accession>
    <name>Q1CZH8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amine oxidase, flavin-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556009.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6060"/>
    <dbReference type="EnsemblBacteria" id="ABF91378">
        <property type="protein sequence ID" value="ABF91378"/>
        <property type="gene ID" value="MXAN_6060"/>
    </dbReference>
    <dbReference type="GeneID" id="41363296"/>
    <dbReference type="KEGG" id="mxa:MXAN_6060"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039679_0_0_7"/>
    <dbReference type="OMA" id="WSSIQGA"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="464" mass="50377" checksum="37C41AB2E64A4F2B" modified="2006-07-11" version="1">MHGWDGQQPVFLHQVSVARNRFRVSLAPPTLIKRAWALFLSGKCGGACVSNPEVIVVGAGLAGLACARALVASRVKVLLLEGSDAPGGRVRTDVHEGFLLDRGFQVYLSAYPEGRRTLDLEALTLRRFAPGAKVWRGGKLHTVADPLRRPVEALGHLFAPVGTFGDKLRILELRQLALSGEVEDVWHRPSRTSRRYLDELGFTEALRESFLRPFFAGIFLERELTTSSRFLEFVFRMFSSGYAAVPESGMGAIPAQLSARLPSGLLRMRAPVADVWGHRVRLADGELIGARAVVVATDPASAVELLPGMVPPVMNRVTCLYFAAPEPPVEGPWLLLNGEGRGRVNNVAVMSEVSPAYAPRGQALVSVSVVGATPDLATLQAEVLAELTDWFGPAVSAWRHLRTYAIPLALPAQPPEVLEPPRRPVRLSPGLFVCGDHRDNASIDGALVSGRRAAEAVLRELERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZX1</accession>
    <name>Q1CZX1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555866.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5915"/>
    <dbReference type="EnsemblBacteria" id="ABF86666">
        <property type="protein sequence ID" value="ABF86666"/>
        <property type="gene ID" value="MXAN_5915"/>
    </dbReference>
    <dbReference type="GeneID" id="41363153"/>
    <dbReference type="KEGG" id="mxa:MXAN_5915"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_1_0_7"/>
    <dbReference type="OMA" id="DHADFPS"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="35532" checksum="A815EB23A2F312A2" modified="2006-07-11" version="1">MSVELRRNGMHLTGTPLSLDAKRKSPLCFVSHGHSDHIARHESTIATAATLRFMTHRLGPVREPREVPFRQPFELGPLVLELLPAGHILGSAQLRVTRPDGRRIVYTGDLNVAPSLTAEATEVAECDTLVIESTFGHPRYRFPPRPEVLGQVETWLRMQLERGAVPVLLGYPLGKSQEAMKHLAGRGFPLVAHSSIYEVAQLYAELGVPIENLRCYDGKVEPGEVLFFPPHHARGGALAPLWPRATAVLTGWAVDRGAVRRYGADVAFPLSDHADFPGLVSYAKSTGAREVLTCHGFAEELAQALRDAGMDARPLGGKPQQLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY2</accession>
    <name>Q1CZY2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ORF">MXAN_5904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555855.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5904"/>
    <dbReference type="TCDB" id="2.A.64.1.2">
        <property type="family name" value="the twin arginine targeting (tat) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91982">
        <property type="protein sequence ID" value="ABF91982"/>
        <property type="gene ID" value="MXAN_5904"/>
    </dbReference>
    <dbReference type="GeneID" id="41363142"/>
    <dbReference type="KEGG" id="mxa:MXAN_5904"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686649_0_0_7"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="OrthoDB" id="1848013at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="43578" checksum="FDD1883807B18611" modified="2006-07-11" version="1">MSLADHLTELRSRLMRCTIAVLILGTISLVFAKPIFGLLMQPVLDALPPENRSLIYTSGIEELNVLMKVGVYCGIFLTTPVILMQIWGFVSPGLYPEERRFAAPFVAFGSIAFLLGAAFCYFAVLPSMFTFLLNEEETLALEQRLDTARLRADDALRFLRLGEAEEAGRIAKETSTQLRAEGQGQAPAPEVAPAASVEMTGRLDGLGRLLDAASVGYGAQSRGVLRQAVEKRVEAVTAYEKKDFAAAAAAMDGSASLLAGIAPTRTEELAGLWRLEKELATAHAAHEAARWTRPMLSMHEQLSLVLLLILAFGIIFELPLVMALLGVVGVVKSSWLFRYQRHAFVVCLIAAAIITPTGDVVNLSLMAGPMLLCYELGVLLVWMVERRRARNSAETGITPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C1</accession>
    <name>Q1D0C1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative general secretion pathway protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555716.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D0C1"/>
    <dbReference type="STRING" id="246197.MXAN_5765"/>
    <dbReference type="EnsemblBacteria" id="ABF86573">
        <property type="protein sequence ID" value="ABF86573"/>
        <property type="gene ID" value="MXAN_5765"/>
    </dbReference>
    <dbReference type="GeneID" id="41363008"/>
    <dbReference type="KEGG" id="mxa:MXAN_5765"/>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024125_3_0_7"/>
    <dbReference type="OMA" id="INTLCDN"/>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="45"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="35055" checksum="6BBE840CF3E2D68C" modified="2006-07-11" version="1">MTTYLDFFELTQEPFSNAPVSRFYYNSAQHSQALTRLMHAVSYMKGLSILVGDIGAGKTTLARRMLDSLPESEYEAALLVIIHSGITANWLLRRIALQLGVENPAQEKLALLSQLYQRLLQIYESGKKAVVLIDEAQMLETRELMEEFRGLLNLEVPERKLISFVFFGLPEIEKNLKLDPPLAQRVAMRYRLEPFTAESTEAYVKHRLRLAGCPRMPFSPEALLAVHQHSSGSPRVINTLCDNALFEAFLAREQTVSAELVHRIGKNLGLLGVNTPAGQAAERPSASASTLPRTTSSKVDLAEIDRYLEGLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D116</accession>
    <name>Q1D116_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5514</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_5514"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="39" mass="4354" checksum="5B70D4741DE63783" modified="2006-07-11" version="1">MVLAREQAVATSRTEAMRSVRITRAIHPQGRPRGPLPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D117</accession>
    <name>Q1D117_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">MXAN_5513</name>
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    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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    <dbReference type="Proteomes" id="UP000002402">
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="599" mass="63478" checksum="845BDA328ECF3233" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D159</accession>
    <name>Q1D159_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Glutathione S-transferase domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_5471</name>
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    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22953" checksum="F2A02250C6CB888C" modified="2006-07-11" version="1">MNDYELIGSPGCGSAIVEMALSITGIPHRLTELPYLEPGPGRDRLLKLNPLGQVPTLILPDGAVMTESAAIILHLHDVSPQSGLVPEPTAPERVRFLNLLFRLVGAVYPTFTYADDPPKWTLPGPAADRLRDTVMERRANLWREIEAQVGKPHVLGKRFSALDLYVTVMTHWRPNKAWFIQNCPALAAAASQAEKNPHVAAVLERHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D164</accession>
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    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S1E (Streptogrisin A) subfamily</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5466</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
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    <dbReference type="STRING" id="246197.MXAN_5466"/>
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        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
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    </dbReference>
    <dbReference type="GeneID" id="41362722"/>
    <dbReference type="KEGG" id="mxa:MXAN_5466"/>
    <dbReference type="eggNOG" id="COG1318">
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ricin_B-like_lectins"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
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    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="452"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="568" mass="59676" checksum="CE8D4F0CF0CD2225" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1C4</accession>
    <name>Q1D1C4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome c</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">MXAN_5402</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Proteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF86299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86299">
        <property type="protein sequence ID" value="ABF86299"/>
        <property type="gene ID" value="MXAN_5402"/>
    </dbReference>
    <dbReference type="GeneID" id="41362665"/>
    <dbReference type="KEGG" id="mxa:MXAN_5402"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="361"/>
            <end position="468"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="468" mass="52825" checksum="FC31C65793CB81DB" modified="2006-07-11" version="1">MKPQGGIPHIAVAVMGLFMMDTGMSHAQEVQRRGSTSYMPVAQTEPFADVMARMKAEKPKITARHQQLLEHRYDLGNRPARGVTMSRGKAVQEGVRVKLPQGVTWESLAAMSPEAIRDRGLFPAGFMPLPHPNHPEGGMVFPKFHIDEIKRQEGRDLTRFDLDFDLPDHLLPEFPPPIFLTTRPDLGDVSQGKLVTIMNVQELFNGLLNPKQLEGLRLLVTPFPQQQFNQTADRRSELPSRGVSCFDCHVNGHSNGATHLVGDIRPQEFRHRIDTPTLRGVNIQRLFGSQRALKTVEDFTEFEQRAAYFDGDPVIATKKGVNILERGSQVHFMAEVQALLDFPPAPKLRFDGKLDPKKATQQEMRGQTLFFGKAQCSVCHLPPYYTDNLMHNLQAERFYKPRLVNGAVMGSDGPIKTFPLRGIKDSPPYLHDGRLMTLEDTVEFFNLVLETRLNAQEKKDLVAFMRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1D9</accession>
    <name>Q1D1D9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5387"/>
    <dbReference type="EnsemblBacteria" id="ABF86142">
        <property type="protein sequence ID" value="ABF86142"/>
        <property type="gene ID" value="MXAN_5387"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="MHELRES"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="563" mass="61453" checksum="75C9B45A583BE6F2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1G0</accession>
    <name>Q1D1G0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="7" type="ORF">MXAN_5363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF87448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5363"/>
    <dbReference type="EnsemblBacteria" id="ABF87448">
        <property type="protein sequence ID" value="ABF87448"/>
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    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5363"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="203"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="32998" checksum="BC1AD773143BA20C" modified="2006-07-11" version="1">MSAGGHPGISHARPGPSWTTRRGCVQTLAIVAKRDKPEAVALAAQIRERYPHLSVLADRTLAHELGWPRVDDRELVTRADLMVVLGGDGTLIYAARLLGGRGVPILGVNLGSLGFMTEVPVEELYPMLEQVLAGRFQVDSRMKLSCRLLRGGRVLIEDEVLNDVVINKGALARIADHETSIDGVPITTYKSDGVILATPTGSTAYSLSAGGPIVHPSVDCTVLSPICSHALTQRSIVVPADRTIRVTLRSETADTYLTIDGQTGHGLQGGDCIEVVRSHNRVNLVRNPKVAYFSILRQKLHWGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1M9</accession>
    <name>Q1D1M9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4034 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555259.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5292"/>
    <dbReference type="EnsemblBacteria" id="ABF88014">
        <property type="protein sequence ID" value="ABF88014"/>
        <property type="gene ID" value="MXAN_5292"/>
    </dbReference>
    <dbReference type="GeneID" id="41362565"/>
    <dbReference type="KEGG" id="mxa:MXAN_5292"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500461_0_0_7"/>
    <dbReference type="OMA" id="ERSGTHY"/>
    <dbReference type="OrthoDB" id="631038at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025115">
        <property type="entry name" value="DUF4034"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13226">
        <property type="entry name" value="DUF4034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4034" evidence="1">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="535" mass="58746" checksum="2609904AA5AA082F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2H6</accession>
    <name>Q1D2H6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554969.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4991"/>
    <dbReference type="ESTHER" id="myxxd-q1d2h6">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92917">
        <property type="protein sequence ID" value="ABF92917"/>
        <property type="gene ID" value="MXAN_4991"/>
    </dbReference>
    <dbReference type="GeneID" id="41362275"/>
    <dbReference type="KEGG" id="mxa:MXAN_4991"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_7"/>
    <dbReference type="OMA" id="IAYTMEL"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="252" mass="26942" checksum="88023A1764B1B224" modified="2006-07-11" version="1">MMGSTGMLNVDDGGVGGLPVVFVHSSAGNTTHWAAQLSYLRERRRALALDLRGHGKSELPRDGGFAVEDFARDVGTVVDGLGLQRFVLVGHSLGGAVCVAYAGAQPDRVAGLFLLDPASDGRSMPAEQARGLMAVLATEAWSAVVEEAWSPMLAPSRPEVRERILSEMRATSQEGVRGGLGALLDFDPVTPLRRYSGPRLSVVTAFNEEPGSYHHLVPELPHAKVEGTGHWVQLDAPDEVNRLLDGFLATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L0</accession>
    <name>Q1D2L0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554935.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4957"/>
    <dbReference type="EnsemblBacteria" id="ABF91496">
        <property type="protein sequence ID" value="ABF91496"/>
        <property type="gene ID" value="MXAN_4957"/>
    </dbReference>
    <dbReference type="GeneID" id="41362242"/>
    <dbReference type="KEGG" id="mxa:MXAN_4957"/>
    <dbReference type="eggNOG" id="COG3975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574551_0_0_7"/>
    <dbReference type="OMA" id="YWTGALF"/>
    <dbReference type="OrthoDB" id="679125at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="559" mass="61357" checksum="88B19C6A298DC8B5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2T9</accession>
    <name>Q1D2T9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartokinase</fullName>
            <ecNumber evidence="9">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_4877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554859.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4877"/>
    <dbReference type="EnsemblBacteria" id="ABF91832">
        <property type="protein sequence ID" value="ABF91832"/>
        <property type="gene ID" value="MXAN_4877"/>
    </dbReference>
    <dbReference type="GeneID" id="41362167"/>
    <dbReference type="KEGG" id="mxa:MXAN_4877"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_7"/>
    <dbReference type="OMA" id="MPIVVQK"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
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        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="11">
        <location>
            <begin position="3"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="42116" checksum="5F44B5F4B9E77223" modified="2006-07-11" version="1">MPIVVQKYGGSSVAGVEKLRKVAQRVKDKREAGYQVVVVVSAMGDTTDELLALAKGVSVDPPRRELDMLLTCGERISMALLSMALQEMDVPAISFTGSQSGIITTDAHAQARIVEVRPYRIHDELARGKVVIVAGYQGVSFKKEVTTLGRGGSDTTAVALAAALDAEACEIYSDVDGVFSADPRVVPDARKLESLSYDEMQELASAGATVLNAQAVEWAKARGITILARTAHGQGTGTAVQELAVPTDHRLKGVTADAEMAVLSASEPIRLAELLEFLDARAVRGRTLDCEGSVGGVRRTVITVPLADIHGADALRRELATRFGDAVSWREDLGTVTCVGVGLNADWAPLRRALAAAEELGAHVHAAHTSPLQLTLLVDKAHLKALTARLHRELLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2U3</accession>
    <name>Q1D2U3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4873"/>
    <dbReference type="EnsemblBacteria" id="ABF87125">
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        <property type="gene ID" value="MXAN_4873"/>
    </dbReference>
    <dbReference type="GeneID" id="41362163"/>
    <dbReference type="KEGG" id="mxa:MXAN_4873"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_3_2_7"/>
    <dbReference type="OMA" id="GSPFEME"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="130"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="35424" checksum="53AC9BE36E7B6E11" modified="2006-07-11" version="1">MAVREMAPKANGEACGVCGGRTYVIERRGDQAQARICACSEHCSVCGGRGHVLVEREGEFSQKMGPRRYEVMETCTCTKLRTRIARFDALGLPASAAHANFENYRSYEEAQDRGRSVAMQFAYQYVQGGSSKGYIISGPVGTGKTHLLAATLAHLALELGVRGRYVEISLLYATIRRGFQEGKSGGEIIGPLSEVEVLAIDELGKGRGSPFEMETLDELIARRYNAGRTTLFATNYSLEPERRAMRSAAPSGYRTTDDSRSAAREAELLRERVGERIYSRLCELCTFVEFPKETPDRRRPRQEMNAPMHHAAGNGRPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2W1</accession>
    <name>Q1D2W1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554837.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4852"/>
    <dbReference type="EnsemblBacteria" id="ABF90700">
        <property type="protein sequence ID" value="ABF90700"/>
        <property type="gene ID" value="MXAN_4852"/>
    </dbReference>
    <dbReference type="GeneID" id="41362147"/>
    <dbReference type="KEGG" id="mxa:MXAN_4852"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_7_7"/>
    <dbReference type="OMA" id="AWIHADQ"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="129"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="37633" checksum="504A282AF633698F" modified="2006-07-11" version="1">MGPFSHSGWNSTKPGQLHNKHSSVDSKRQILRDHILPFFGKVALANIGLAEIEDFKAHMRKKKSAAHKRKDSASKRAIRKRQRSEPKPLSLKTINNVLTVLHKLLTLAEEHGVIRQAPRVKPFGKLPKPPFDFLSFEEADQLLAVAEPEWRTLLRVAIKTGLRQGELIGLRWHDLTLTRGLLHVRRTIWRGIEGLPKGGRERTVDLPASVVDALNAHRHRRGRFVFCQEDGQPLTKGKMAAPLGRALRAAGITREVGQIGWHDLRHTYGSHLAMRGIPLKVIQELIGHATIEMTNRYAHLSPDTRREAVAVLDRPLALPCDIRATWKEAAPNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2X9</accession>
    <name>Q1D2X9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554819.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4833"/>
    <dbReference type="EnsemblBacteria" id="ABF91189">
        <property type="protein sequence ID" value="ABF91189"/>
        <property type="gene ID" value="MXAN_4833"/>
    </dbReference>
    <dbReference type="GeneID" id="41362130"/>
    <dbReference type="KEGG" id="mxa:MXAN_4833"/>
    <dbReference type="eggNOG" id="ENOG5031JIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142833_0_0_7"/>
    <dbReference type="OMA" id="ANFFIAA"/>
    <dbReference type="OrthoDB" id="1691359at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="15918" checksum="464C26ED7BDF4F4C" modified="2006-07-11" version="1">MSEQKPRLKRPVENVRAELLADPDTQRIAKSLDMELEAYVELVLDYAQNPDKEPTLIVAPDEELRAAGYNPPTTQDVANFFIAAANGELGIGPPKSYYSGFEGKQDDANKPSLRGDEGQEPVKVDEETSQKLRQHVPKGGPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q7</accession>
    <name>Q1D3Q7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554543.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4548"/>
    <dbReference type="EnsemblBacteria" id="ABF90029">
        <property type="protein sequence ID" value="ABF90029"/>
        <property type="gene ID" value="MXAN_4548"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4548"/>
    <dbReference type="eggNOG" id="ENOG5031FQN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2288516_0_0_7"/>
    <dbReference type="OMA" id="ACSCAFH"/>
    <dbReference type="OrthoDB" id="1891154at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="11067" checksum="F0C0500E24EF8E5E" modified="2006-07-11" version="1">MFDSCGGCERRGGAGEVFDWCAHCELSLCPRCMERGCCDNEPADSGRSAPRCLPEPPEDDEATALPEHFGGRCCTRARAVACSCAFHWVCAHHGDQHIGTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D455</accession>
    <name>Q1D455_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">MXAN_4395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554396.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4395"/>
    <dbReference type="EnsemblBacteria" id="ABF88450">
        <property type="protein sequence ID" value="ABF88450"/>
        <property type="gene ID" value="MXAN_4395"/>
    </dbReference>
    <dbReference type="GeneID" id="41361705"/>
    <dbReference type="KEGG" id="mxa:MXAN_4395"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_7"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="189"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="194"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="310"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="406" mass="42504" checksum="973019C126F97B5B" modified="2006-07-11" version="1">MDVTTLKGRRVVVGVGGGIAAYKACELVRELSRAGAEVRVAMTESARQFVTPLTFQALSGHPVLTDYFDPAQEGNFGHLDLARWAEVFVVAPATADLLARIRAGMGNDAVTTSLLAFRGPVVLAPAMNVAMWDNPLTQENLAALLAYPRFSRVGPGAGMLACGDVGEGRLADVPAIVQAVAARFGAGPLAGKRVLLTAGPTREFLDPVRFISNPSTGKMGMALAHAARTLGAEVTVVLGPVGTVERGGLDIVDVVSADDMAREVLSRVGTVDVFIATAAVSDWRPETRAPQKVKKGASTSPEALTLVRTPDVLAEASRQVAGQPKRPVLVGFAAETERVVAHARDKLERKGLDAIVANDVTAPGAGFGTDTNRVTVLTRSGAQHELQGSKREVAQALIELLLVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4C3</accession>
    <name>Q1D4C3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4324"/>
    <dbReference type="EnsemblBacteria" id="ABF90911">
        <property type="protein sequence ID" value="ABF90911"/>
        <property type="gene ID" value="MXAN_4324"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4324"/>
    <dbReference type="HOGENOM" id="CLU_1007710_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="31133" checksum="DEC38C0518969A7C" modified="2006-07-11" version="1">MLVELQPKAGQYAVVHESGTVSDNGQHTRPAGHDFANRRTNSDRSVMTAIHSHKAHPLDAPGFLGGKVLDLEDHSRFAFALEDRGINFGIRIFARNVVKDCERGLRNRPRREQGSQGVVLGGLLFAVAFVLFHQGVVLRECINQRGVHRRVALPVLEHVDLLVEDWCPVVVFLRPRWPHKERDLRSIRQGHDQRKAVIAVEIPDGLQDDLVVDHREWFESTFPAEHLRLARVDGLLEAQRRDDLPLHVDGVGPVLRMLGEQDGPPIVIGGLRTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F4</accession>
    <name>Q1D4F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenical pump-driving ATPase</fullName>
            <ecNumber evidence="4">3.6.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554297.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4294"/>
    <dbReference type="EnsemblBacteria" id="ABF92911">
        <property type="protein sequence ID" value="ABF92911"/>
        <property type="gene ID" value="MXAN_4294"/>
    </dbReference>
    <dbReference type="GeneID" id="41361605"/>
    <dbReference type="KEGG" id="mxa:MXAN_4294"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_1_0_7"/>
    <dbReference type="OMA" id="PHEPAIS"/>
    <dbReference type="OrthoDB" id="1225869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="3">
        <location>
            <begin position="320"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="41567" checksum="00EAA62C93AF44E3" modified="2006-07-11" version="1">MARIILVSGTGGSGKTTVAAATALAASRRGLRTLVLSFDLSRGLSAAMGVESPLFSGPRGVPVGVNDHLSFHEVDVGEELRRGWNGGQGGLAALVDGGPERVNAEEVAMTAEAAHVVMLLRLGEYLHEQQHDLVIVDCPSTRTALQLLNTVPAMSWYARQQQTPTQAGRKARLLAASLHGADASLEVRDRLNAVDALLHDPEVTTLRLVTTADTVAGQEAQRAYTYFSLLGLAVDCVVINRLAPEAADAGSDPMRAQQSHVEKLQRAFSSLLVLKVPHQAMEVVGEKPLEVFAEQLYQGEDPVRLTAPQPALGIRKDAVDAYSLEVRLPFVAKSDVELSRRGAEFVIQVGAVRRNVVLPRMIALLPTSGARMEGDRLIVSFQKERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4J7</accession>
    <name>Q1D4J7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554254.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4251"/>
    <dbReference type="EnsemblBacteria" id="ABF86035">
        <property type="protein sequence ID" value="ABF86035"/>
        <property type="gene ID" value="MXAN_4251"/>
    </dbReference>
    <dbReference type="GeneID" id="41361566"/>
    <dbReference type="KEGG" id="mxa:MXAN_4251"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019119_0_0_7"/>
    <dbReference type="OMA" id="TQELFEY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="483"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="707" mass="77149" checksum="CCE16F3F520358A1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D527</accession>
    <name>Q1D527_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554075.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4068"/>
    <dbReference type="EnsemblBacteria" id="ABF87452">
        <property type="protein sequence ID" value="ABF87452"/>
        <property type="gene ID" value="MXAN_4068"/>
    </dbReference>
    <dbReference type="GeneID" id="41361398"/>
    <dbReference type="KEGG" id="mxa:MXAN_4068"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_2_1_7"/>
    <dbReference type="OMA" id="RMNEGEP"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="79" mass="9006" checksum="CF7FB4B78C141FDA" modified="2006-07-11" version="1">MRDMTARLDITREVCPMTYVRTKLKLESLEPGTLLEVLLRGTEPLKNVPRNARDEGHEVVSLDALPDGTHRLVLRKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5E1</accession>
    <name>Q1D5E1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3952"/>
    <dbReference type="EnsemblBacteria" id="ABF88464">
        <property type="protein sequence ID" value="ABF88464"/>
        <property type="gene ID" value="MXAN_3952"/>
    </dbReference>
    <dbReference type="GeneID" id="41361284"/>
    <dbReference type="KEGG" id="mxa:MXAN_3952"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_95_2_7"/>
    <dbReference type="OMA" id="HVNGPRR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="207"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="57924" checksum="E33D0616FF6B7808" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5G5</accession>
    <name>Q1D5G5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3928"/>
    <dbReference type="EnsemblBacteria" id="ABF89352">
        <property type="protein sequence ID" value="ABF89352"/>
        <property type="gene ID" value="MXAN_3928"/>
    </dbReference>
    <dbReference type="GeneID" id="41361259"/>
    <dbReference type="KEGG" id="mxa:MXAN_3928"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836323_0_0_7"/>
    <dbReference type="OMA" id="AQFIYER"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="35"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="37778" checksum="D061B95D87459B93" modified="2006-07-11" version="1">MSARIRERQESWGTIIYDNLRDEFSAKVFEGCVPVPRSPIGCGWLVTAPCNLVCIHCYGNVEDLPSKRLSTPQQLKVADEVIRAGIMRQILSGGEPLMRRDTLNVIDKLTDHGVATILGTNGTFLTQQMMKTVSRCTRVEISLDSMDERVNNEIRPSRNAKGNTYQETLRAMGLCVDHGVAPRILTCLNRHNSQHVEELAQFIYERGIRDWAISWTLSAGRAYHIYGELMPEETSHVTAAVERLRVRYPDMQIRLSDRTVNYSRYYFLIWPDGIMGTEEIVTGKKLFFASLVTGSVQDGWKQENYDLDAHFRKWVGDRIEVIPAEGRKPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5H2</accession>
    <name>Q1D5H2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553931.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3921"/>
    <dbReference type="EnsemblBacteria" id="ABF87695">
        <property type="protein sequence ID" value="ABF87695"/>
        <property type="gene ID" value="MXAN_3921"/>
    </dbReference>
    <dbReference type="GeneID" id="41361252"/>
    <dbReference type="KEGG" id="mxa:MXAN_3921"/>
    <dbReference type="eggNOG" id="COG4654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133112_1_0_7"/>
    <dbReference type="OMA" id="MGCHQVD"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002324">
        <property type="entry name" value="Cyt_c_ID"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00606">
        <property type="entry name" value="CYTCHROMECID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188241" evidence="5">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="11026" checksum="5A68A4AD3BC39511" modified="2006-07-11" version="1">MKRFLWLSVFAVASVSNVASASEELSKAKNCSTCHSATARLVGPSFKEIAARYAKQEGVEDKLAQRVRKGSSGVWGAIPMPANAQVSEAEARALVKWIMTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z5</accession>
    <name>Q1D5Z5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553759.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3746"/>
    <dbReference type="EnsemblBacteria" id="ABF87537">
        <property type="protein sequence ID" value="ABF87537"/>
        <property type="gene ID" value="MXAN_3746"/>
    </dbReference>
    <dbReference type="GeneID" id="41361079"/>
    <dbReference type="KEGG" id="mxa:MXAN_3746"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_7"/>
    <dbReference type="OMA" id="GFGPKRY"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="333" mass="35323" checksum="BCCBE0C28A0C7D24" modified="2006-07-11" version="1">MRFLLTGGTGFIGQRLARRIVERGDTLTLMVRASSRRGPLEGLGARFVVADLTTGAGLAEAVRDVDCVLHLAGVTKSREPEGYIEGNAKGTRRLVEAMAALPHPPRLVYCSSLAAAGPSTPERPRREEDPPAPVSIYGRSKLGGEEAVRAFADRVPSVIVRPPIVYGPGDVEFLPSLLPMAKLGLALKSGFGPKRYSLIHVDDLCTALLAAADRGPTVSKEDPARGVYAVSDGVEHSWEDVCTAMAGALGKGRPAVLPVPQTVSYVVGLGSEAVARLRGTVPILNRDKVREMRCPAWTCSTERANRELGFLPTIPLAQGLAGTLAAYREAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D697</accession>
    <name>Q1D697_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-chelator utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553657.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3639"/>
    <dbReference type="EnsemblBacteria" id="ABF89135">
        <property type="protein sequence ID" value="ABF89135"/>
        <property type="gene ID" value="MXAN_3639"/>
    </dbReference>
    <dbReference type="GeneID" id="41360976"/>
    <dbReference type="KEGG" id="mxa:MXAN_3639"/>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_4_0_7"/>
    <dbReference type="OMA" id="VHAFVHG"/>
    <dbReference type="OrthoDB" id="1630289at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29989" checksum="6DFA49ADFCD4F088" modified="2006-07-11" version="1">MTTTTERVYRRGPFPVKFRLLEVKRVTRVTPQMVRITLAGEDLEGFYSPGADDHVKLLFPEEGKRMPVIPTVTPTGLVLKEGERKPDARDYTPRRYDAAAGELDIDFVVHGTGPATTWASKAQVGDLLAVGGPRGSTFVAQDFSWYLLAGDQSALPAIGRILEELPEGTRAIVFCEVPDASEEQHFTTRANATVTWLHRNGVEAGHSDVLQQAIRGLEFPAGDYFAWVAGEAHTVRPIKDHLINERGANKSWVRVTGYWKRGTSDHHDAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6B2</accession>
    <name>Q1D6B2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lant_dehydr_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553642.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3624"/>
    <dbReference type="EnsemblBacteria" id="ABF92418">
        <property type="protein sequence ID" value="ABF92418"/>
        <property type="gene ID" value="MXAN_3624"/>
    </dbReference>
    <dbReference type="GeneID" id="41360962"/>
    <dbReference type="KEGG" id="mxa:MXAN_3624"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011068_1_0_7"/>
    <dbReference type="OMA" id="LTAARWM"/>
    <dbReference type="OrthoDB" id="1406236at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="70"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="754" mass="82643" checksum="8C835BF16FE925ED" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6B5</accession>
    <name>Q1D6B5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3621"/>
    <dbReference type="EnsemblBacteria" id="ABF88343">
        <property type="protein sequence ID" value="ABF88343"/>
        <property type="gene ID" value="MXAN_3621"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3621"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_16_6_7"/>
    <dbReference type="OMA" id="EYATARL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1056"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1096" mass="117584" checksum="1603E3BA7A0D92CC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F4</accession>
    <name>Q1D7F4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553265.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3220"/>
    <dbReference type="EnsemblBacteria" id="ABF92585">
        <property type="protein sequence ID" value="ABF92585"/>
        <property type="gene ID" value="MXAN_3220"/>
    </dbReference>
    <dbReference type="GeneID" id="41360574"/>
    <dbReference type="KEGG" id="mxa:MXAN_3220"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_4_2_7"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="29252" checksum="71466A9129400F5C" modified="2006-07-11" version="1">MPESPRRIAFQGEPGAYGEEALRALHGADVEAVPCLTFRAVFEAVAEGRVHGGVVPVESSLGGPVAETVDLLLEHDVPATGELSLRIRHCLLAPPGLSLDDVQQALSHPQALAQCAGYLRRRGISPLPEANTAIAARKVAEEKPPHTAAIASRMSADLYGLAVLEEGVEDSPDNFTRFIALGTAPERTWTRRKTALAFTVENGPGALFRVMSAFSSRGLNVARLESRPQRRAWEYVWCLDVDGALEDPRVREAVAAAQAACVTLRVLGSYGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Y5</accession>
    <name>Q1D7Y5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine/AMP deaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553085.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3029"/>
    <dbReference type="EnsemblBacteria" id="ABF87221">
        <property type="protein sequence ID" value="ABF87221"/>
        <property type="gene ID" value="MXAN_3029"/>
    </dbReference>
    <dbReference type="GeneID" id="41360391"/>
    <dbReference type="KEGG" id="mxa:MXAN_3029"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_0_0_7"/>
    <dbReference type="OMA" id="RGWFRFQ"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="331" mass="37708" checksum="FC6E7430964295DB" modified="2006-07-11" version="1">MARDLIDLHIHVGGAVAPHILWSIAHQQGFKLPVKNYFDFVELITSRPGKVGSLDDYLKILHTWTEKIQSSPSAIERSVYEVIGKEYRGSRVTQMELRFNPMKRNLNSELDLDHIIHAALRGMDRAVLEYGVKMGLIFCLAREFDHRLNSIIVDKAIKYRTRGVYGIDLAGTETNAMELKPEVVTQYEELFSRARRAGLKCTVHTGETRGTGAEGVMAVVEKLQPHRIGHGIRAAYDEHAMKVLRERDLVLELCPTSNLHTKAVEGVEELRHIVRTFWDRKVKFTINTDGPYLLETDMRREIDIIEQNGILTPEQVDQTLAWAREASFIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D882</accession>
    <name>Q1D882_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552990.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2930"/>
    <dbReference type="EnsemblBacteria" id="ABF87727">
        <property type="protein sequence ID" value="ABF87727"/>
        <property type="gene ID" value="MXAN_2930"/>
    </dbReference>
    <dbReference type="GeneID" id="41360297"/>
    <dbReference type="KEGG" id="mxa:MXAN_2930"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972629_0_0_7"/>
    <dbReference type="OMA" id="LDQEAQH"/>
    <dbReference type="OrthoDB" id="1735819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="30317" checksum="58AF2A2CD3DFDF93" modified="2006-07-11" version="1">MSDFREERDDALNALVLPLDEGVGPARRISRERSARMVLTALEAGALVTPPAPRPLGKRPPVWLMAGALLVAGAAAAAVWNFTRSSRASTSQVESAALMGPPRLGTESRRIGSGVVDAAPSRLDAVSDEASPETPVVPAASIAEAEPARPRAPLASVKSAAPEDLLLKANALRSEGRWKEAEALYLRVIRAEPSSLASYVARVASGSLRLEHLGDARGALRQFKAALRVQPRGVLDQEAQHGIAEAHRVLGDRDAERSALESFLSTHPDSPLVPSARARVRELTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8B6</accession>
    <name>Q1D8B6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fvmX7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552957.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2896"/>
    <dbReference type="EnsemblBacteria" id="ABF90996">
        <property type="protein sequence ID" value="ABF90996"/>
        <property type="gene ID" value="MXAN_2896"/>
    </dbReference>
    <dbReference type="GeneID" id="41360264"/>
    <dbReference type="KEGG" id="mxa:MXAN_2896"/>
    <dbReference type="eggNOG" id="COG4861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_284960_0_0_7"/>
    <dbReference type="OMA" id="NTNSHFC"/>
    <dbReference type="OrthoDB" id="43101at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045486">
        <property type="entry name" value="fvmX7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20005">
        <property type="entry name" value="fvmX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="fvmX7" evidence="2">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1090" mass="116861" checksum="57CBE0734DB13FC1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8C8</accession>
    <name>Q1D8C8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552945.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2884"/>
    <dbReference type="EnsemblBacteria" id="ABF87018">
        <property type="protein sequence ID" value="ABF87018"/>
        <property type="gene ID" value="MXAN_2884"/>
    </dbReference>
    <dbReference type="GeneID" id="41360253"/>
    <dbReference type="KEGG" id="mxa:MXAN_2884"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370816_0_0_7"/>
    <dbReference type="OMA" id="GMAYTHH"/>
    <dbReference type="OrthoDB" id="105174at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AAA_16" evidence="3">
        <location>
            <begin position="94"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="671"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="804" mass="86749" checksum="93D87E83CD71EEB1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8L5</accession>
    <name>Q1D8L5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protease B</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prtB</name>
        <name evidence="1" type="ORF">MXAN_2791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552858.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2791"/>
    <dbReference type="MEROPS" id="M57.001"/>
    <dbReference type="EnsemblBacteria" id="ABF86622">
        <property type="protein sequence ID" value="ABF86622"/>
        <property type="gene ID" value="MXAN_2791"/>
    </dbReference>
    <dbReference type="GeneID" id="41360167"/>
    <dbReference type="KEGG" id="mxa:MXAN_2791"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052330_0_0_7"/>
    <dbReference type="OMA" id="HTDWFSR"/>
    <dbReference type="OrthoDB" id="1415414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024653">
        <property type="entry name" value="Peptidase_M10/M27/M57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12388">
        <property type="entry name" value="Peptidase_M57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="265" mass="27512" checksum="393435123B2485E1" modified="2006-07-11" version="1">MPMFKKMFKGAAVLAVTGSMMLTGCGTDVQADSQHEQDEIISNLVEAGFPADDILLSDGQVYVGRDAHVTLEASREMLQTDLKTQEQYRTTNLVAASITRICIVPNSAYAANTTLMSALDRAIANYNALGLSFTMQRGGSGCSATISARTMSGAGGSAGFPSGGRPYGIINIGTGTATYGVAVVEHVVTHELGHAVGLRHSDYYNRSISCGGAATNEGTAGVGAIHIPGTPTTATRGGSLMNSCFGSSETGNFKSSDVTALQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Z4</accession>
    <name>Q1D8Z4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552730.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2660"/>
    <dbReference type="EnsemblBacteria" id="ABF90168">
        <property type="protein sequence ID" value="ABF90168"/>
        <property type="gene ID" value="MXAN_2660"/>
    </dbReference>
    <dbReference type="GeneID" id="41360036"/>
    <dbReference type="KEGG" id="mxa:MXAN_2660"/>
    <dbReference type="HOGENOM" id="CLU_400026_0_0_7"/>
    <dbReference type="OMA" id="YNYSFPE"/>
    <dbReference type="OrthoDB" id="70427at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="656" mass="71268" checksum="0741B4014B5063B3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9A5</accession>
    <name>Q1D9A5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pkn5</name>
        <name evidence="6" type="ORF">MXAN_2549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552619.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D9A5"/>
    <dbReference type="STRING" id="246197.MXAN_2549"/>
    <dbReference type="EnsemblBacteria" id="ABF92541">
        <property type="protein sequence ID" value="ABF92541"/>
        <property type="gene ID" value="MXAN_2549"/>
    </dbReference>
    <dbReference type="GeneID" id="41359927"/>
    <dbReference type="KEGG" id="mxa:MXAN_2549"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="PSMAPMW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="380" mass="41924" checksum="DC3ADFB24420C1F1" modified="2006-07-11" version="1">MPLKVIGPYRVLETLGSGGAGTVYRALDRRTTDEVALKLLSAGPARDARAARRLAREFDTLVDLSHPNVVKVFESGVHQGVPYLAMELIEGLTLRHYLDLSSGDRQTPPGSHTPRSPLSVLRTADDDFGPLSRSFSDSMDDSEDSPFDGTFGLEAFAEEAPSEDLESFASSASPHVGIGSDDSLEGFDLPPPMPRPAEPEEEPGRVVREEDLNRPERMGRLKDAMLQICEALAYIHGHGLVHRDLKPSNIMVDDDRQVRLMDFGLAKFLADDAAITEAGKLVGTYRYMAPEQILGEPLDGRADLYSLGVILYELLSGRPPFDAKTPHELWRQVLETEPPPVLALNLHGDPQLARVAHRLIRKEPDDRFQTAEEVYEALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D1</accession>
    <name>Q1D9D1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552594.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2523"/>
    <dbReference type="EnsemblBacteria" id="ABF91012">
        <property type="protein sequence ID" value="ABF91012"/>
        <property type="gene ID" value="MXAN_2523"/>
    </dbReference>
    <dbReference type="GeneID" id="41359900"/>
    <dbReference type="KEGG" id="mxa:MXAN_2523"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517606_0_0_7"/>
    <dbReference type="OMA" id="ALAHTYQ"/>
    <dbReference type="OrthoDB" id="851444at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="56073" checksum="CA90B9F410922149" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9L8</accession>
    <name>Q1D9L8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2435"/>
    <dbReference type="EnsemblBacteria" id="ABF90161">
        <property type="protein sequence ID" value="ABF90161"/>
        <property type="gene ID" value="MXAN_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2435"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793225_0_0_7"/>
    <dbReference type="OMA" id="GYLWLDM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="15930" checksum="8B3A915A7D872149" modified="2006-07-11" version="1">MSPKGASMADTSEISNSLVPLGRQQARVLLEAGYLWLDMGHFDKAKEIFSGAAALMPRSEVPQLALGAVEFSQGRHDKALQAYRVAQRLAPQSGLPRAHAGEALLFMGKVPEALKELKAAMDLDPDGDGARLAQSLIQAKEAGVLPPAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9P0</accession>
    <name>Q1D9P0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552488.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2413"/>
    <dbReference type="EnsemblBacteria" id="ABF90461">
        <property type="protein sequence ID" value="ABF90461"/>
        <property type="gene ID" value="MXAN_2413"/>
    </dbReference>
    <dbReference type="GeneID" id="41359797"/>
    <dbReference type="KEGG" id="mxa:MXAN_2413"/>
    <dbReference type="eggNOG" id="ENOG502Z9Y1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_273404_0_0_7"/>
    <dbReference type="OMA" id="KETHNIF"/>
    <dbReference type="OrthoDB" id="286403at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1177" mass="124084" checksum="324D32617636D203" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W8</accession>
    <name>Q1D9W8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfite reductase [NADPH] flavoprotein alpha-component</fullName>
            <shortName evidence="10">SiR-FP</shortName>
            <ecNumber evidence="10">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cysJ</name>
        <name evidence="14" type="ORF">MXAN_2335</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -&gt; FAD -&gt; FMN to the hemoprotein component.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="10 11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552410.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2335"/>
    <dbReference type="EnsemblBacteria" id="ABF91013">
        <property type="protein sequence ID" value="ABF91013"/>
        <property type="gene ID" value="MXAN_2335"/>
    </dbReference>
    <dbReference type="GeneID" id="41359721"/>
    <dbReference type="KEGG" id="mxa:MXAN_2335"/>
    <dbReference type="eggNOG" id="COG0369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_7_7"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="707164at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010199">
        <property type="entry name" value="CysJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000207">
        <property type="entry name" value="SiR-FP_CysJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01931">
        <property type="entry name" value="cysJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0288">FMN</keyword>
    <keyword evidence="6 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="12">
        <location>
            <begin position="71"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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            <begin position="528"/>
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</entry>
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<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
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            <dbReference type="EMBL" id="ABF90460.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="71" mass="7905" checksum="54FCF284F1291DE8" modified="2006-07-11" version="1">MTPRKPRTTKPARAPEATLERIASETLNIETLKTRNSDSLDFHDVPVWRLKEALEAAYQAGLSAASNPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBA1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020479225.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91153">
        <property type="protein sequence ID" value="ABF91153"/>
        <property type="gene ID" value="MXAN_1826"/>
    </dbReference>
    <dbReference type="GeneID" id="41359243"/>
    <dbReference type="KEGG" id="mxa:MXAN_1826"/>
    <dbReference type="HOGENOM" id="CLU_2143161_0_0_7"/>
    <dbReference type="OrthoDB" id="1942667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="112" mass="12464" checksum="E6FFBC7574C86C64" modified="2006-07-11" version="1">MSTTAVPFYIVPIKVIDFSNARLSLDLGKNQVGRAQPQLDIFLPGAPHRQLSALLHTYAASLELNTPPNERWLIRTDCCVEPNHGRIFLELAEGDHAEAMRGMMLLNALLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBJ0</accession>
    <name>Q1DBJ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551842.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1733"/>
    <dbReference type="EnsemblBacteria" id="ABF90677">
        <property type="protein sequence ID" value="ABF90677"/>
        <property type="gene ID" value="MXAN_1733"/>
    </dbReference>
    <dbReference type="GeneID" id="41359167"/>
    <dbReference type="KEGG" id="mxa:MXAN_1733"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349075_0_0_7"/>
    <dbReference type="OMA" id="GCRADCQ"/>
    <dbReference type="OrthoDB" id="99348at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043543">
        <property type="entry name" value="PAPPA/PAPPA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46130">
        <property type="entry name" value="PTHR46130"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13948">
        <property type="entry name" value="DUF4215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="883" mass="90270" checksum="8DE640F382EA7A77" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC43</accession>
    <name>Q1DC43_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative long-chain-fatty-acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551639.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DC43"/>
    <dbReference type="STRING" id="246197.MXAN_1528"/>
    <dbReference type="EnsemblBacteria" id="ABF88003">
        <property type="protein sequence ID" value="ABF88003"/>
        <property type="gene ID" value="MXAN_1528"/>
    </dbReference>
    <dbReference type="GeneID" id="41358973"/>
    <dbReference type="KEGG" id="mxa:MXAN_1528"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247289_0_0_7"/>
    <dbReference type="OMA" id="LHHTFEF"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1450"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1470" mass="162309" checksum="2D37AE4460ACCE63" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC8</accession>
    <name>CINAL_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_1438</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551554.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCC8"/>
    <dbReference type="SMR" id="Q1DCC8"/>
    <dbReference type="STRING" id="246197.MXAN_1438"/>
    <dbReference type="PRIDE" id="Q1DCC8"/>
    <dbReference type="EnsemblBacteria" id="ABF87889">
        <property type="protein sequence ID" value="ABF87889"/>
        <property type="gene ID" value="MXAN_1438"/>
    </dbReference>
    <dbReference type="GeneID" id="41358884"/>
    <dbReference type="KEGG" id="mxa:MXAN_1438"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_7"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000058717" description="CinA-like protein">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <sequence length="421" mass="44639" checksum="62AE8F1472B8BE34" modified="2006-07-11" version="1">MRVELLCTGDELVTGLITDTNSTYLEARLFDLGVKVERVVLVGDVRPDIIQSLKEAASRADVVVVSGGLGPTADDFTLECAAEAAGVPLEEDAQVLDWLHQRYAARGLSPNPSALRMARVPQGSEPVKNPEGSAPLVVMKLGGAQLFFLPGVPREFKALLEGEVLPRIRATLDARPERTYRAFRLLRTVGIPESELDIAVAPMGPRHPRIVFGFRTHAPENHLKLMAEAPSQSEADAALAAVEVECRQMLGTKLFGVDSEAYAAVVLETLRRAGATLAVAESCTGGLIAQQLTAVPGSSEVFIGGAVVYSEKMKSAWVGVPPDVLARHTAVSRETAEAMAEGVRDACGTTYGLSVTGYAGPGGGTPEDPVGTVYCALSAPGVPTRCERISVTGDRDRVRLFAASHTLEMLRQHLLAAPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCE8</accession>
    <name>Q1DCE8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1418"/>
    <dbReference type="EnsemblBacteria" id="ABF88548">
        <property type="protein sequence ID" value="ABF88548"/>
        <property type="gene ID" value="MXAN_1418"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1418"/>
    <dbReference type="HOGENOM" id="CLU_823641_0_0_7"/>
    <dbReference type="OMA" id="CSDPVDK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="378" mass="40763" checksum="E151CF8CB817AB73" modified="2006-07-11" version="1">MGVLSLARPHASHCLLLVYAPRNLPALSYPPGGVVSRLKKSAFTLAVALAAVGCSDPVDKAAKARIFSPEDPPKVVASAKEKLPPEDVADNPQVARRILGMDAAEVTERLGPHRYQATLGYEWTSEASIPVKLTETRTFRAGPGGVSGDFHGVLENSRDQGLEVMRVGGQVFARNRYGPFRQRLRDRGMAERTRAELTGAIRDFDSLFQGRIKLTPEGTVTHEGRTAWRYVVTLAPAAQADASRPLPPTPQAKKGGVDETTVRRANFFAHRLPRSLDGEVLVDSATSVVLKARLDGRMGVPGDKTPEAAELRLTLEAALSEVGKDPRLQPPEDFLPDADKPQGIADALDTFGIQRKKPSDSDSASPESAPEPEDEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCF0</accession>
    <name>Q1DCF0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551533.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1416"/>
    <dbReference type="EnsemblBacteria" id="ABF89516">
        <property type="protein sequence ID" value="ABF89516"/>
        <property type="gene ID" value="MXAN_1416"/>
    </dbReference>
    <dbReference type="GeneID" id="41358862"/>
    <dbReference type="KEGG" id="mxa:MXAN_1416"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_7"/>
    <dbReference type="OMA" id="HEHQPRV"/>
    <dbReference type="OrthoDB" id="1094766at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="26027" checksum="730365E722104689" modified="2006-07-11" version="1">MTTTSKTVVVTGASRGIGRAVALGFAKAGHDVWALARSTEALESLRQEGGERIRPLAVDVADEAALIAASQRILAEGPPRVLVNNAGITVSAPLAKTRTEDLARVMAVNVTAPFLLCRELMPAMAQAGGGRVINIGSMAAVRGVKYTSAYCASKHALLGLTRALAVEYAKKQVTVNIVNPGWVETDMFAGATSAISASTGRSEEQAREALASMNAMGRIITPEEVAALCLFLASDAAGGITGSAYAIDGGELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI3</accession>
    <name>Q1DCI3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">ggt</name>
        <name evidence="6" type="ORF">MXAN_1383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551500.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1383"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="EnsemblBacteria" id="ABF88912">
        <property type="protein sequence ID" value="ABF88912"/>
        <property type="gene ID" value="MXAN_1383"/>
    </dbReference>
    <dbReference type="GeneID" id="41358830"/>
    <dbReference type="KEGG" id="mxa:MXAN_1383"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_3_7"/>
    <dbReference type="OMA" id="FMVIGSP"/>
    <dbReference type="OrthoDB" id="595845at2"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="602" mass="62852" checksum="108CEC741B605AE7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK0</accession>
    <name>Q1DCK0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551483.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1366"/>
    <dbReference type="EnsemblBacteria" id="ABF85977">
        <property type="protein sequence ID" value="ABF85977"/>
        <property type="gene ID" value="MXAN_1366"/>
    </dbReference>
    <dbReference type="GeneID" id="41358812"/>
    <dbReference type="KEGG" id="mxa:MXAN_1366"/>
    <dbReference type="HOGENOM" id="CLU_1609046_0_0_7"/>
    <dbReference type="OMA" id="AKCKDRR"/>
    <dbReference type="OrthoDB" id="1626284at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17361" checksum="6C38E90F8F3A66A1" modified="2006-07-11" version="1">MTHFASRRGSALAITLIALTVLLLLVVGAITFTGRNQSAAVAKTRSDRVEACAETARRYLLSRLKVFGTGAVPVTSISLEQVLQDDQVVADSSVMRTAHLGDTASAPTAAVLASSSFSSGKDQVSDAANTLREGTAGGSYYRVVVMCDEPGGRQAETEFVFRFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL0</accession>
    <name>Q1DCL0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hflX</name>
        <name evidence="8" type="ORF">MXAN_1356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1356"/>
    <dbReference type="EnsemblBacteria" id="ABF90422">
        <property type="protein sequence ID" value="ABF90422"/>
        <property type="gene ID" value="MXAN_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1356"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_7_1_7"/>
    <dbReference type="OMA" id="TGRGVQM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="378"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="550" mass="60967" checksum="D3B408AF245CFE4B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCR8</accession>
    <name>Q1DCR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551415.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1298"/>
    <dbReference type="EnsemblBacteria" id="ABF92603">
        <property type="protein sequence ID" value="ABF92603"/>
        <property type="gene ID" value="MXAN_1298"/>
    </dbReference>
    <dbReference type="GeneID" id="41358744"/>
    <dbReference type="KEGG" id="mxa:MXAN_1298"/>
    <dbReference type="HOGENOM" id="CLU_1641885_0_0_7"/>
    <dbReference type="OMA" id="DFRQDGT"/>
    <dbReference type="OrthoDB" id="1684546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="16753" checksum="1199359511FF7B43" modified="2006-07-11" version="1">MRSRRAVILGLLGGGLAVSGCLGSVPFRPRAYEDAVRVVGFQVDFRQDGTGVLDLDLAVTNPASDAATLAAVDFTLRVDGRRVAVGTQQVAAPLAADGSAPLRVLFPLASARATGGPEPVPRRVQVEGGVVLRFGGTERRAPFRSERVLPLAWVPPLDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW6</accession>
    <name>Q1DCW6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="325"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="599" mass="64343" checksum="8B5B30C67C93B26D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCY4</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="99" mass="10095" checksum="29E0B9A791FB3E4F" modified="2006-07-11" version="1">MKLGALVLAVLLALPASGSEVVSVERAQLFPDGGSAAVEVEGGCWLAESRCIRTASEIARLRAENESLRQQAGDVSFTVAVVALLAGLGAGFAVARLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCZ6</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1218"/>
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        <property type="protein sequence ID" value="ABF88133"/>
        <property type="gene ID" value="MXAN_1218"/>
    </dbReference>
    <dbReference type="GeneID" id="41358667"/>
    <dbReference type="KEGG" id="mxa:MXAN_1218"/>
    <dbReference type="eggNOG" id="ENOG5033EZY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="SHVIYTE"/>
    <dbReference type="OrthoDB" id="2014275at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="12016" checksum="B75CE828208B201F" modified="2006-07-11" version="1">MSGPASLFRQRVSYAEVVGRDAWGTPLLGPIQEAPARIQPSRKLIRDANGAEFVASFVVYTEAPVTLRHRLWFKGDDITDFNHARRPAAVDEHVDGAGVLRYRKVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD19</accession>
    <name>Q1DD19_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1195"/>
    <dbReference type="HOGENOM" id="CLU_234024_0_0_7"/>
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    <dbReference type="OrthoDB" id="796378at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1994" mass="195896" checksum="D1943D651459F7D6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE2</accession>
    <name>Q1DDE2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ORF">MXAN_1071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="ABF92733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551191.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1071"/>
    <dbReference type="EnsemblBacteria" id="ABF92733">
        <property type="protein sequence ID" value="ABF92733"/>
        <property type="gene ID" value="MXAN_1071"/>
    </dbReference>
    <dbReference type="GeneID" id="41358522"/>
    <dbReference type="KEGG" id="mxa:MXAN_1071"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_0_1_7"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="160"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="17629" checksum="68EB8B7A86AC1C98" modified="2006-07-11" version="1">MAGGVNKVILIGNLGADPEVRFTPGGQAVANFRIATSESWVDKNGQKQERTEWHRIVVWGKLAELCGEYLKKGRQCYVEGRLQTREWTDKENRKNYTTEVVANAVTFLGGGGRDAGDGMGGGGGGGGRRQFSQQRGGDNNDYGQPPPDDMGGGHGGGNGDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDV2</accession>
    <name>Q1DDV2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551031.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0910"/>
    <dbReference type="EnsemblBacteria" id="ABF91517">
        <property type="protein sequence ID" value="ABF91517"/>
        <property type="gene ID" value="MXAN_0910"/>
    </dbReference>
    <dbReference type="GeneID" id="41358369"/>
    <dbReference type="KEGG" id="mxa:MXAN_0910"/>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547279_0_0_7"/>
    <dbReference type="OMA" id="FSCRFNV"/>
    <dbReference type="OrthoDB" id="1213112at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="507" mass="55359" checksum="6F06141467E71B84" modified="2006-07-11" version="1">MRLHGALMGLTLMCAGCATLSRGFGATANEDTGEYETPEEELVYIVPAEDAMMVARRILEEQRYDVMEKEGGLEMFSSAHEPGKNMPGLRTIERYYIKGERLGPRQTVVRVFRLSYNEMETQLEIPPQAAGKREAAMFAVLDAHPFDATRDAFTYANGPNGPRAVPMEDPFKNAPGMERMRMVRGVRDLDIERTLLQRLEMVPALELVGSNAPVPIRSVTPEGGQTEQAQQAPECGTPVDGAGPLMAPGHVLLLADPLGTRELPAAALRMLCEATAQGLPVTLALSLPASEQPLLETYLASPGQFQDLQTMMSESPFWRRTYQDGRSSSAMLWLIEQARRLRASGKDISVVAFDAEKAQGNEREAEMARHLLAHQQTRAQAWTLVLAGGTHVRTAGVNWDSDYAPLGARLAQVLPSVRALDVGFTRGTQFSCRFNVWDAVECNVFAISPTKEVRQKPDIASGVRLFPQPLAEGFHGRLYVGALSASPPALHRLAPTTAAQTPPATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE60</accession>
    <name>Q1DE60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0800"/>
    <dbReference type="EnsemblBacteria" id="ABF89513">
        <property type="protein sequence ID" value="ABF89513"/>
        <property type="gene ID" value="MXAN_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0800"/>
    <dbReference type="HOGENOM" id="CLU_2317335_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="99" mass="10554" checksum="FE5EF9B813D59235" modified="2006-07-11" version="1">MKGGTTHLSRVKTKWPCSPPWRAAPASEGQLMEILGATILGVVIFSVLIMGVILGGAMGHKQERNLREITERQQAAGITGDVTMNDNAFACPPDQTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEC3</accession>
    <name>Q1DEC3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0734"/>
    <dbReference type="EnsemblBacteria" id="ABF85922">
        <property type="protein sequence ID" value="ABF85922"/>
        <property type="gene ID" value="MXAN_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0734"/>
    <dbReference type="eggNOG" id="COG3287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713542_0_0_7"/>
    <dbReference type="OMA" id="THHILPR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="2">
        <location>
            <begin position="231"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="41188" checksum="0EE48784FBFE3280" modified="2006-07-11" version="1">MQTARTTLREPDAAAEDLLSQLGSDTPRLVTMFASRERDQLALNRAVRQRLPADTRLIGATTAGELDNTGIHEGSVVMSALFGDFEVGLGLGTGLSVDAISAGAAAIKRACEDLGVRQQDLDPRRFVGLVIDDGFRYKKEELLLGILEKCQTLVLVGGGASDANRDPAKQSAMVHVDGEVATDAVLVALFKTSAPWAALRSHWYVPTGEKLTITKVDESHTRALEIDGHPAAKRYAEILGVGVEELEFGTPRGFAVRPTALRVGREYFIRAAWSPQEDGSILFANLLEEGTELELMKLGDMAGMTRSFFTDEVPRRVQNPQAALLFHCGGRMWYASATNTAQQLAETLKAAPTAAGMNVHFEIYSGFHINTTLTALVFGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF1</accession>
    <name>Q1DEF1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain fatty acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550832.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0704"/>
    <dbReference type="EnsemblBacteria" id="ABF89965">
        <property type="protein sequence ID" value="ABF89965"/>
        <property type="gene ID" value="MXAN_0704"/>
    </dbReference>
    <dbReference type="GeneID" id="41358177"/>
    <dbReference type="KEGG" id="mxa:MXAN_0704"/>
    <dbReference type="eggNOG" id="COG2031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037744_0_0_7"/>
    <dbReference type="OMA" id="QDKTIAH"/>
    <dbReference type="OrthoDB" id="350103at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006160">
        <property type="entry name" value="SCFA_transpt_AtoE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41983">
        <property type="entry name" value="PTHR41983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02667">
        <property type="entry name" value="SCFA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="48558" checksum="DB0846D3AFF998A6" modified="2006-07-11" version="1">METLVRIAESLGRFSSRFVPSAFAIAVLLTLLTMALATGWAGAAPPAVLDAWGGGFWELLGFSMQMALVMFTGYLLALTGPVRALLERAARVPRTPRGAAAWMAFVSMALAYVNWGLSLVASAMLVRFMVKRRPDVDYRLLVACAYFGLGATWHSGLSASAPLLVATPGHFLEKSLGVLPIDRTLFSPFNIGLTLAVVAGLTLLAWLLHPKPENTVRVDPAVLESLGDFTPPPRPSERGFAAWLDHSRLLNTVIGVLGLVWLARHLWMNGGWRALNLNVVNFTFLVLAVLLHGTPARLLKASEEAGTVLHGIVLQFPLYAGIYGIFKATGLTERIGELFVSLSTRETFPAIVYLYSGVVNYFVPSGGSKWAIEAPYLLDAATRLGVAPEKVVLAYAWGDMATDLIQPFWALPLLAVARLEFKELLGFLLVAFLVYLPLVTLAFFLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP2</accession>
    <name>Q1DEP2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neutral ceramidase</fullName>
            <ecNumber evidence="3">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550744.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0613"/>
    <dbReference type="EnsemblBacteria" id="ABF89280">
        <property type="protein sequence ID" value="ABF89280"/>
        <property type="gene ID" value="MXAN_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="41358091"/>
    <dbReference type="KEGG" id="mxa:MXAN_0613"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011300_2_0_7"/>
    <dbReference type="OMA" id="VWHRTNT"/>
    <dbReference type="OrthoDB" id="704008at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102121">
        <property type="term" value="F:ceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="PTHR12670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188456" description="Neutral ceramidase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Ceramidase_alk" evidence="5">
        <location>
            <begin position="50"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Ceramidse_alk_C" evidence="6">
        <location>
            <begin position="524"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="686" mass="73582" checksum="1FA28603BC217B39" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP6</accession>
    <name>Q1DEP6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550740.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0609"/>
    <dbReference type="EnsemblBacteria" id="ABF91494">
        <property type="protein sequence ID" value="ABF91494"/>
        <property type="gene ID" value="MXAN_0609"/>
    </dbReference>
    <dbReference type="GeneID" id="41358087"/>
    <dbReference type="KEGG" id="mxa:MXAN_0609"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_3_0_7"/>
    <dbReference type="OMA" id="DLVPHGM"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="98"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25497" checksum="BE0BBEDC259BA728" modified="2006-07-11" version="1">MSGWDVAVTRPLGLLLLVLVCCLGFIALSDEVAEGETQQLDERMLLALRNPEDPAQPRGPWWLRRTAEDVTALGGIPVLTLATLAVCGFLLLVRRYRTLLLVLGATLGGAGLNVLLKQFFARPRPSVVPHLTEVVSQSFPSGHAMLSATVYLTLGALLAQLAERKRLKLYVLTVALLLSFLVGLTRVYLGVHYPTDVLGGWVAGLAWALLMAVCARTLRRRSPALRAEARRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEV9</accession>
    <name>Q1DEV9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550677.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0545"/>
    <dbReference type="EnsemblBacteria" id="ABF89480">
        <property type="protein sequence ID" value="ABF89480"/>
        <property type="gene ID" value="MXAN_0545"/>
    </dbReference>
    <dbReference type="GeneID" id="41358029"/>
    <dbReference type="KEGG" id="mxa:MXAN_0545"/>
    <dbReference type="HOGENOM" id="CLU_209775_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="60" mass="6805" checksum="B2471525669F266E" modified="2006-07-11" version="1">MLELSDPNVWRIPMVKAKTKTKASKQTKKLTQALRELNKTTKPAGSANVFNTCSRFMYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEW9</accession>
    <name>Q1DEW9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA topoisomerase III/ATP-dependent DNA helicase, RecQ family</fullName>
            <ecNumber evidence="17">3.6.1.-</ecNumber>
            <ecNumber evidence="17">5.99.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">topB</name>
        <name evidence="17" type="ORF">MXAN_0535</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="853"/>
            <end position="1021"/>
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        <location>
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            <end position="522"/>
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            <end position="829"/>
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        <location>
            <begin position="1401"/>
            <end position="1490"/>
        </location>
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        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
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        <location>
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            <end position="774"/>
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            <begin position="1402"/>
            <end position="1422"/>
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            <end position="1453"/>
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        <location>
            <begin position="1454"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1560" mass="169640" checksum="FD557844D1843C64" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEY7</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="GNAT"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="8"/>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="148" mass="16447" checksum="B7261EF83D04ECBF" modified="2006-07-11" version="1">MTAGATFTFIHPGHPLYAGEMELRFRVLREPLGYTRDDVAFPFEADSLHLVAHQEEGVLGCVLFNPEDAHGGRLFQMAVASHLQGQGLGARLVRTLEAELVRRGFTHVHLHAREPAVPFYERLGYAVFGAPYTEVGVPHRNMRKTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF16</accession>
    <name>Q1DF16_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92043">
        <property type="protein sequence ID" value="ABF92043"/>
        <property type="gene ID" value="MXAN_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0487"/>
    <dbReference type="HOGENOM" id="CLU_3273142_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="41" mass="4579" checksum="6328D9583D14FD5D" modified="2006-07-11" version="1">MMKEERLRPLVVRCSELLHRHPVFLEVLGFISGDDSGSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG12</accession>
    <name>Q1DG12_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550275.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0128"/>
    <dbReference type="EnsemblBacteria" id="ABF92929">
        <property type="protein sequence ID" value="ABF92929"/>
        <property type="gene ID" value="MXAN_0128"/>
    </dbReference>
    <dbReference type="GeneID" id="41357632"/>
    <dbReference type="KEGG" id="mxa:MXAN_0128"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027067_0_0_7"/>
    <dbReference type="OMA" id="KGCATEQ"/>
    <dbReference type="OrthoDB" id="1537888at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021655">
        <property type="entry name" value="Put_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11617">
        <property type="entry name" value="Cu-binding_MopE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="679" mass="72047" checksum="6FD3013E0F0F03C2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG88</accession>
    <name>Q1DG88_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550201.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0052"/>
    <dbReference type="EnsemblBacteria" id="ABF92174">
        <property type="protein sequence ID" value="ABF92174"/>
        <property type="gene ID" value="MXAN_0052"/>
    </dbReference>
    <dbReference type="GeneID" id="41357561"/>
    <dbReference type="KEGG" id="mxa:MXAN_0052"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045796_0_0_7"/>
    <dbReference type="OMA" id="HWQARVG"/>
    <dbReference type="OrthoDB" id="994146at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="347" mass="38109" checksum="8520DCED115F98A3" modified="2006-07-11" version="1">MGHPSTENLTPFTFEPLFLTDEALRPLFVPVLKATFDLRPRGAPTLSAEQAPLLTGGERWDGGDVASLRLEPEGAFFKAATDVVLVGHAHAPAAGTRELLAELHVGPVHKQVRVLGDRTWFKSMGGIGVTQPLPFERVPVRYERAFGGKDGSAFESRNPLGMGFREKGSRFEENLRLPNLESPTEPLRSWGQRPPPTGFGFIEPHWQPRAGYAGTYDDAWKKSRSPLLPKDFDRRFLNGAPQDQLVPGYLRGGEAVLLKHMAPGAPLTFRLPALPSPEVLAPRARGLDDLEGALRLDTVVLDTDAMKLFLVWRGTFALQREPTELRSIQVTCEGAETLEPGQPVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB3</accession>
    <name>Q1DGB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550176.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0027"/>
    <dbReference type="EnsemblBacteria" id="ABF86134">
        <property type="protein sequence ID" value="ABF86134"/>
        <property type="gene ID" value="MXAN_0027"/>
    </dbReference>
    <dbReference type="GeneID" id="41357536"/>
    <dbReference type="KEGG" id="mxa:MXAN_0027"/>
    <dbReference type="HOGENOM" id="CLU_1146240_0_0_7"/>
    <dbReference type="OMA" id="YVLEQTA"/>
    <dbReference type="OrthoDB" id="1162776at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="31688" checksum="95707B48460ECAB3" modified="2006-07-11" version="1">MRRPIWIHTSGGASDGRIECGDAVNPSRLAHPCGYDAGAIIRAVLPRRRVTPRTSMKTNASVLAVMTCSLLTAPLAIADNTAPVKSASVDLNGDGTPEAVSIQFDEPKNEFILKAGSATIRGPGDDNEPAGVFIVDLDSRDKRKELVVRTGQTDYDQRSYIYGFDGKALKLLGTVPALTEAKGNGIILSDSWQGFWNRRDKYVVDAKTGKVSEVPQDLYAVGVEATVKQSFPLARSRTDKSAVATLAQGSKIQVLAAAPPGRKGEGYLYLVKSSTGLLGWATAKDLTWKTDGLPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q306N4</accession>
    <name>Q306N4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilO</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type IV pilus biogenesis protein PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilO</name>
        <name evidence="3" type="ORF">MXAN_5774</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="1249" last="1261">
            <title>The pilH gene encodes an ABC transporter homologue required for type IV pilus biogenesis and social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Wu J."/>
                <person name="Cheng Y.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9767592"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01013.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="24" last="33">
            <title>The Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pilus biogenesis, social motility, and development.</title>
            <authorList>
                <person name="Wall D."/>
                <person name="Kolenbrander P.E."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9864308"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>New pil genes required for pilus assembly, S-motility, and Tgl stimulation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="6">
        <citation type="journal article" date="2016" name="Science" volume="351" first="aad2001" last="aad2001">
            <title>Architecture of the type IVa pilus machine.</title>
            <authorList>
                <person name="Chang Y.W."/>
                <person name="Rettberg L.A."/>
                <person name="Treuner-Lange A."/>
                <person name="Iwasa J."/>
                <person name="Sogaard-Andersen L."/>
                <person name="Jensen G.J."/>
            </authorList>
            <dbReference type="PubMed" id="26965631"/>
            <dbReference type="DOI" id="10.1126/science.aad2001"/>
        </citation>
        <scope>STRUCTURE BY NMR</scope>
    </reference>
    <dbReference type="EMBL" id="DQ242507">
        <property type="protein sequence ID" value="ABB43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555725.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JC8">
        <property type="method" value="EM"/>
        <property type="chains" value="Oa/Ob/Oc/Od/Oe/Of/Og/Oh/Oi/Oj/Ok/Ol=1-205"/>
    </dbReference>
    <dbReference type="PDB" id="3JC9">
        <property type="method" value="EM"/>
        <property type="chains" value="Oa/Ob/Oc/Od/Oe/Of/Og/Oh/Oi/Oj/Ok/Ol=1-205"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JC8"/>
    <dbReference type="PDBsum" id="3JC9"/>
    <dbReference type="STRING" id="246197.MXAN_5774"/>
    <dbReference type="EnsemblBacteria" id="ABF90968">
        <property type="protein sequence ID" value="ABF90968"/>
        <property type="gene ID" value="MXAN_5774"/>
    </dbReference>
    <dbReference type="GeneID" id="41363017"/>
    <dbReference type="KEGG" id="mxa:MXAN_5774"/>
    <dbReference type="eggNOG" id="COG3167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102444_0_0_7"/>
    <dbReference type="OMA" id="TARTFRY"/>
    <dbReference type="OrthoDB" id="1803493at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3JC8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3JC9"/>
        </source>
    </evidence>
    <sequence length="205" mass="22883" checksum="5C6E887B707D0463" modified="2005-12-06" version="1">MDKYLDQFVKAPPAIKFGGLAFVVGALTAANFFMVIQPTEEEIGWAVAERRKLDLELADKSEIAQNLNERRREMDVLEQKLSEALTELPEQRDIEELLAQINDIGKKSGLELSSVTPGKESVGGGEFFARIPIKMTVSGNYHEIALFLQEMANMRRIVNVNNIKFDSAKLKNEKVVLQSEFQATTFRFVEQKAAASTAGNSNSKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-28" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S449</accession>
    <accession>Q1D807</accession>
    <accession>Q84F98</accession>
    <name>TRMFO_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="1">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmFO</name>
        <name type="synonym">gid</name>
        <name type="synonym">gidA</name>
        <name type="ordered locus">MXAN_3007</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Mol. Microbiol." volume="36" first="662" last="678">
            <title>AglU, a protein required for gliding motility and spore maturation in Myxococcus xanthus, is related to WD-repeat proteins.</title>
            <authorList>
                <person name="White D.J."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="10844655"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2000.01887.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Mol. Microbiol." volume="49" first="555" last="570">
            <title>Identification of genes required for adventurous gliding motility in Myxococcus xanthus with the transposable element mariner.</title>
            <authorList>
                <person name="Youderian P.A."/>
                <person name="Burke N."/>
                <person name="White D.J."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="12828649"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2003.03582.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="503" last="517">
            <title>GidA is an FAD-binding protein involved in development of Myxococcus xanthus.</title>
            <authorList>
                <person name="White D.J."/>
                <person name="Merod R."/>
                <person name="Thomasson B."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="11703671"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02659.x"/>
        </citation>
        <scope>FAD-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="1"/>
    <dbReference type="EMBL" id="AF162663">
        <property type="protein sequence ID" value="AAD46374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY204472">
        <property type="protein sequence ID" value="AAO22919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553063.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S449"/>
    <dbReference type="SMR" id="Q9S449"/>
    <dbReference type="STRING" id="246197.MXAN_3007"/>
    <dbReference type="EnsemblBacteria" id="ABF92331">
        <property type="protein sequence ID" value="ABF92331"/>
        <property type="gene ID" value="MXAN_3007"/>
    </dbReference>
    <dbReference type="GeneID" id="41360368"/>
    <dbReference type="KEGG" id="mxa:MXAN_3007"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_7"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117253" description="Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD46374." evidence="3" ref="1">
        <original>EQ</original>
        <variation>DE</variation>
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD46374." evidence="3" ref="1">
        <original>Y</original>
        <variation>S</variation>
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD46374." evidence="3" ref="1">
        <original>D</original>
        <variation>N</variation>
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD46374." evidence="3" ref="1">
        <original>Q</original>
        <variation>H</variation>
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD46374." evidence="3" ref="1">
        <original>R</original>
        <variation>L</variation>
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD46374." evidence="3" ref="1">
        <original>I</original>
        <variation>M</variation>
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11703671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="457" mass="49764" checksum="BE51C4E247353970" modified="2006-09-19" version="2">MADQKQRVTVIGGGLAGTECAYQLSRRGVPVVLREMKPQKRSPAHKSDTLAELVCSNSLRSDNPESAIGLLHAELRALGSLVLSAADANRVPAGDALAVERERFSAAITESLLRQPGVELVAGEVEQLPEDGPVVIATGPLTSDALTRELERHVGTRLYFYDSIAPILSADSIDMNVAFRQSRYGKGGGDDYLNLPMTKDEYYRFIAEVKAGQKVVPHAFEEPKYFEGCLPIEVMAERGDDTLAYGPMKPVGLRDPRTGQEPYAVVQLRMEDVGGTSWNMVGFQTRLTWGEQKRIFSSFIPGLQQAEFLRMGQIHRNTFIDSPRLLAKDLSLKTEPRLYFAGQISGVEGYVESAACGYLVALALHARLTGTEFVPPPATTAMGALLRHVTGEAHPPDYPHQPSNISFGIFSPLTGRMKKAEKRAAYSARAKQDLAAWLPHAGVPAAGAPEHVDQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVN5</accession>
    <name>Q1CVN5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557341.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7433"/>
    <dbReference type="EnsemblBacteria" id="ABF85861">
        <property type="protein sequence ID" value="ABF85861"/>
        <property type="gene ID" value="MXAN_7433"/>
    </dbReference>
    <dbReference type="GeneID" id="41364583"/>
    <dbReference type="KEGG" id="mxa:MXAN_7433"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019123_1_0_7"/>
    <dbReference type="OMA" id="KLRGSYW"/>
    <dbReference type="OrthoDB" id="692608at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021908">
        <property type="entry name" value="DUF3520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022156">
        <property type="entry name" value="Uncharacterised_YfbK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12034">
        <property type="entry name" value="DUF3520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12450">
        <property type="entry name" value="vWF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187915" evidence="2">
        <location>
            <begin position="23"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="335"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="700" mass="76353" checksum="3E838B2A78E96E83" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVQ7</accession>
    <name>Q1CVQ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557321.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7410"/>
    <dbReference type="EnsemblBacteria" id="ABF87473">
        <property type="protein sequence ID" value="ABF87473"/>
        <property type="gene ID" value="MXAN_7410"/>
    </dbReference>
    <dbReference type="GeneID" id="41364566"/>
    <dbReference type="KEGG" id="mxa:MXAN_7410"/>
    <dbReference type="eggNOG" id="ENOG502ZZV4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077132_0_0_7"/>
    <dbReference type="OMA" id="EINAWHK"/>
    <dbReference type="OrthoDB" id="1664282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="26523" checksum="7767FD80E5BA9EF3" modified="2006-07-11" version="1">MSRFFWMHEDKAAAAKYGGEINAWHKLSLPGVSCGTCGETWAHTGHEYPCVDLAQLPERNEFARPRPEPFPEFARLRELVRPLVPPGAELPPGTGFGPLVGRATGVFGPIAWVWGQKLLVQREALSRLHSEGVQGLQACPTQLRFRQKDPPELLELQIEPHGRLHPDCIPPDEPPPCVTCGRFGLTRPDAPILDAASLPTGLDLFRVGNFSTMIVGTERFMEAVRRLDLDGITFQALPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV9</accession>
    <name>Q1CVV9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7356"/>
    <dbReference type="EnsemblBacteria" id="ABF92490">
        <property type="protein sequence ID" value="ABF92490"/>
        <property type="gene ID" value="MXAN_7356"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7356"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051820_2_1_7"/>
    <dbReference type="OMA" id="YVYETRE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="38"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="288" mass="32645" checksum="A1F8C517BE0EC76B" modified="2006-07-11" version="1">MLKGWSMSQAPTPVRFKGTDTYLTHESLQAAVNCALTLQRPLLVKGEPGTGKTLLAEAIAEALGHRLITWHVKSTTRAQDGLYVYDTVQRLYDSRFNDGDVRDIRKYIRQGPLGEAFSSPERVVLLIDEVDKADLEFPNDLLHELDRMRFRVTETGDEVVAKHRPVVVITSNNEKELPDAFLRRCVFHFIDFPDAELMRRIVGVHHPGLDSALSEQALKVFYELRSFTRLRKKPSTSELIDWIAVLKAQGVNDLKLDEQLPFLGALLKKEQDLVSVAEAFGRGRRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW13</accession>
    <name>Q1CW13_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88356">
        <property type="protein sequence ID" value="ABF88356"/>
        <property type="gene ID" value="MXAN_7297"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7297"/>
    <dbReference type="HOGENOM" id="CLU_154541_0_0_7"/>
    <dbReference type="OMA" id="FETTFVK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="16837" checksum="C263E92E6B5A8BBB" modified="2006-07-11" version="1">MSVMLTRVSGGSDMQQLEWTFGSHSVRYEAPDVVQATFVGPIDLDEIKRAVDVYGEIAQQYGPYYLIADIGRSQLGAEPRRYLSENGKADWFKGTVYVGADVVQQTFGKVIALGMLFTGKARFETTFVKDHDEARAWVAQHRQKNKKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW52</accession>
    <name>Q1CW52_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557177.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87752">
        <property type="protein sequence ID" value="ABF87752"/>
        <property type="gene ID" value="MXAN_7258"/>
    </dbReference>
    <dbReference type="GeneID" id="41364424"/>
    <dbReference type="KEGG" id="mxa:MXAN_7258"/>
    <dbReference type="HOGENOM" id="CLU_1128514_0_0_7"/>
    <dbReference type="OMA" id="EQADCPV"/>
    <dbReference type="OrthoDB" id="1939117at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="28261" checksum="79F3FC28681D29C5" modified="2006-07-11" version="1">MMPYAMKELLKYINGFEPAFSDQAQGASAVEVSRLESLLKRPLPSHYKDFLLSMGRSMGSLREEDTDFAIGRILKFYETSKRHPPRRYIFIGAQLVDTYGRFLLDCGEATEQADCPVVQADPEEPFKNEDHIVPLYGPLKDMLFLMAFSRKRMALLEHRRRFLPSLVRSGTGNVRIVAPSLVGAIDETLLQLGFQTLPYTSPLTPLYERGDAAFYVDRSSQGGGLSAELAARDEREFGRLVEVIQDSTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW87</accession>
    <name>Q1CW87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7223"/>
    <dbReference type="EnsemblBacteria" id="ABF88141">
        <property type="protein sequence ID" value="ABF88141"/>
        <property type="gene ID" value="MXAN_7223"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7223"/>
    <dbReference type="eggNOG" id="ENOG503196Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979447_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="284" mass="31665" checksum="FB6C399CEBEC3BF4" modified="2006-07-11" version="1">MRPVRQPVQSGPERACNALRHSFSRGSRLHVDIHGLALQSLGMARRERAAVVIHLQREERMVRVDQVDVVATDEVHVGELHQVVAPGNGHQPLLQFEVRVPDARHAPDDMACRRPHGHAFVYVVCPNHSGLLALGCPARPGLPDNSASGHDGTHLQWRTRWSARDDGPPLHHHANAGAAEPHVLPGEREAPGRQPWRTPGRHRGHMGGCVPNVPGRRCTMLLELSAVEARDVKQALDTALRALLEEMAHADPHAHRDLLRERYERLDQLNRRLDMSLEGEQVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW95</accession>
    <name>Q1CW95_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557134.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7215"/>
    <dbReference type="EnsemblBacteria" id="ABF92754">
        <property type="protein sequence ID" value="ABF92754"/>
        <property type="gene ID" value="MXAN_7215"/>
    </dbReference>
    <dbReference type="GeneID" id="41364385"/>
    <dbReference type="KEGG" id="mxa:MXAN_7215"/>
    <dbReference type="eggNOG" id="ENOG5030YWJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068858_0_0_7"/>
    <dbReference type="OMA" id="CSEAIAV"/>
    <dbReference type="OrthoDB" id="2049340at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="27521" checksum="989101A73C2334B8" modified="2006-07-11" version="1">MSEHLSDLVLDEVVAGGAQPPHLTHCTTCRARLEQLRTHAEEIRPRAHFSRVRAHVLSEAAALPQERATPWFARWMLVPILATLATVVVVRGSMTEVPETTPAGPETPPPLLGMRVKGPPHVELLRLKDGAVNPLLQEGDEVALRLRSGGQRYALVVVMDSEKLVEALWPQAGLQSGELATAQPAPLFQVTQGDFVVHALYSETPLRLDTVRDWLSTLRPECRAAPMPAACLSLASTPPGVAHAAVSLQVEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWE0</accession>
    <name>Q1CWE0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TonB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89095">
        <property type="protein sequence ID" value="ABF89095"/>
        <property type="gene ID" value="MXAN_7170"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7170"/>
    <dbReference type="HOGENOM" id="CLU_110225_0_0_7"/>
    <dbReference type="OMA" id="MIRCTIK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TonB_C" evidence="1">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="24435" checksum="D2D6D920A8BCD0A8" modified="2006-07-11" version="1">MDGTHGVRGAWRGLLQKRRAAPRAALRAWDGEGLTTGTRDAHTCPHPRTGARWEVRVSASRFRPTPLTLKGETMHMPGLVSLLLLSAPVLAAEPATQDKAVFEAELQRNLEAFEKNMDRSMPIPCGHPPMRPERIKGEDLQFAPSQLTRIKETTYQLRCTFHLDGTATDCQMLKPGVDLDAKSRETIKQWRFKPAIYKDKPIATTCTVSGKLKRRPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH9</accession>
    <name>Q1CWH9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557050.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7131"/>
    <dbReference type="EnsemblBacteria" id="ABF86327">
        <property type="protein sequence ID" value="ABF86327"/>
        <property type="gene ID" value="MXAN_7131"/>
    </dbReference>
    <dbReference type="GeneID" id="41364304"/>
    <dbReference type="KEGG" id="mxa:MXAN_7131"/>
    <dbReference type="HOGENOM" id="CLU_120443_1_0_7"/>
    <dbReference type="OMA" id="DIKYHRS"/>
    <dbReference type="OrthoDB" id="1968586at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="22844" checksum="407467169A32033C" modified="2006-07-11" version="1">MGRLVRERGIVRYFEIETLGDINNSELLFLDQEPEVLGLDGYCLAAGEPIGTDYPSEVKVKPSEEHAGIQLSSLLGNNFNYLIASAAVKEAVSEHCVEAAIEYLPFTLLDHRERVRSQDYFFINPLGSIDAVDAAASDIKYHRSGAVVAIRKLVLDPQKLIGAPGLFRLKQDPQRYIVSEPLVRAFKERGFTNLVLREIAVSAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI2</accession>
    <name>Q1CWI2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557047.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7128"/>
    <dbReference type="EnsemblBacteria" id="ABF88805">
        <property type="protein sequence ID" value="ABF88805"/>
        <property type="gene ID" value="MXAN_7128"/>
    </dbReference>
    <dbReference type="GeneID" id="41364302"/>
    <dbReference type="KEGG" id="mxa:MXAN_7128"/>
    <dbReference type="eggNOG" id="ENOG502ZE8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347358_0_0_7"/>
    <dbReference type="OMA" id="YAVFLWF"/>
    <dbReference type="OrthoDB" id="1395163at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22663" checksum="1F0C99C50BF79D5E" modified="2006-07-11" version="1">MPSPHTRALLAILAAVCIVAAAGFRHAQNVKGSRGGRISGPKLAWLFYAVFLWFLACPLVALDVAVPEEARGVLGAFAAFMWLRGVAELYLLYGVKRWRPPYGVAHDVACIALVLGGLFWGRARWLGVLGPEDLWALAFLGLVLVSLFVEVAYAALFFHAVEGRTTGEDGIWFADEEQARFRRINRLTLALNVPLYAGLVGLLAVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWK4</accession>
    <name>Q1CWK4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat (Twin-arginine translocation) pathway signal sequence domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557025.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7106"/>
    <dbReference type="EnsemblBacteria" id="ABF88663">
        <property type="protein sequence ID" value="ABF88663"/>
        <property type="gene ID" value="MXAN_7106"/>
    </dbReference>
    <dbReference type="GeneID" id="41364280"/>
    <dbReference type="KEGG" id="mxa:MXAN_7106"/>
    <dbReference type="eggNOG" id="COG2960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044709_0_0_7"/>
    <dbReference type="OMA" id="CDSGYAC"/>
    <dbReference type="OrthoDB" id="497249at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011447">
        <property type="entry name" value="DUF1552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07586">
        <property type="entry name" value="HXXSHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="48088" checksum="33C85D034DD78206" modified="2006-07-11" version="1">MSKKFRLSRRTVLRGTGALMALPLLEQMIPRNAHGAPGTVPRRLAVFYTPNGIHMQKWTPKIEGPAWELTPTLEPLAAVKNDLLVVTGLANQPAFPDGDGHHAAATGAFLSCAKVYKTEGTNLRVGISMDQVIANHMTATRATRYGSMELGIDAGRGIGNCDSGYACPYANNIAWSGPRTPVAKETNAQAAFNRLFAGGIPGETQAQIEKRRAYGKSIIDVVRDDATALKGQLGTSDLQKLDEYFTSVRELEKQVEDVSVPSMACASGAAPIVSEDPTAKTKAMMDLIILAFQCDLTRVATFMLANARANKVYPFLGLSGAHHTYSHHQKSQSNYNALATIDKWEVTLLQYLLERMKSVIEANGLSMLDNSMVYFSSEIGDGDSHNHVNLPIILAGKGGGALTPGRHIVYQQDPLANLYIYLMQAMGVPNVTTFGDDGTGPLPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR4</accession>
    <name>Q1CWR4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556965.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7046"/>
    <dbReference type="EnsemblBacteria" id="ABF89136">
        <property type="protein sequence ID" value="ABF89136"/>
        <property type="gene ID" value="MXAN_7046"/>
    </dbReference>
    <dbReference type="GeneID" id="41364221"/>
    <dbReference type="KEGG" id="mxa:MXAN_7046"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009318_3_2_7"/>
    <dbReference type="OMA" id="TLYQTHF"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="417" mass="44345" checksum="68D1D35DBF948E44" modified="2006-07-11" version="1">MSHRTPWWMPALALLMAGCDENSARVVGVTPPDGLDYAHEEPWREGTFIPPPGPGGRILVTNSLDDTLSLVELATVGTPDFRELARVPVGLNPVELEGPHHTAVSPAGDFYYVGISNYVPGGGSGPHGAHGTGADDGYCLKLDARNNRLVGSVRVNPNPGDVIISADGSTLYQTHFDTLKISEMARQGRPESDMNANLAIIDARTMTRKAMVEVCPAPHAVRLSADERTAYIACWSDEVAIVDLAEAKPTVARVKVVAAGSGGAVAPRHQPYALTLSPTTGEVWVSSMASRQVHVLNPQTRTMMHERAVPLRGPPMFGAFTADGRTLYMPYQLVDALAVIDPETGTVLREVQLADAGCLNVHQVTLTPDERIGLVVCEGDHVGPGTLHAVDLTEGTVVGTVEVGIFPDSVSILRGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX78</accession>
    <name>Q1CX78_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556803.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6880"/>
    <dbReference type="EnsemblBacteria" id="ABF91255">
        <property type="protein sequence ID" value="ABF91255"/>
        <property type="gene ID" value="MXAN_6880"/>
    </dbReference>
    <dbReference type="GeneID" id="41364067"/>
    <dbReference type="KEGG" id="mxa:MXAN_6880"/>
    <dbReference type="HOGENOM" id="CLU_138404_0_0_7"/>
    <dbReference type="OMA" id="VWVPEVC"/>
    <dbReference type="OrthoDB" id="1739942at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187721" evidence="2">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="18706" checksum="6FA0F79F34CC1AB6" modified="2006-07-11" version="1">MFRGGPRQKVQAGRRRRTTMALKTGFAVLAFGMMFLGSTAAHAKDDNEKSRFSQQHRHDGRGGNFGVHVDARRHPGPAPLPPPHARGRYELQTVNRWVQGRYEQVWVPEVCRERNNRRSRVTRCTGGFYEQRWVPARYEPVQEWVWVTYAPGRVHVASAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXN4</accession>
    <name>Q1CXN4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556647.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6722"/>
    <dbReference type="EnsemblBacteria" id="ABF88166">
        <property type="protein sequence ID" value="ABF88166"/>
        <property type="gene ID" value="MXAN_6722"/>
    </dbReference>
    <dbReference type="GeneID" id="41363915"/>
    <dbReference type="KEGG" id="mxa:MXAN_6722"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_2_7"/>
    <dbReference type="OMA" id="YQHALAW"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26590" checksum="921B9CD6D4447B06" modified="2006-07-11" version="1">MVENVIFDVDGTLVDSVDEHAEAWRRAFLHFGRDIPFAHVRSQIGKGADQLIPVFFNDEEVERFGKELDEYRGKLFLDEFLPKVRPFPRVRELFQRLRAGGIRIVLASSAKEQELKHYVKLCGIEGLFETKTSADEVDKSKPHPDIFEAALARLGKPSPDVTVVVGDTPYDALAANKSSLPSVGVLAGGFPPDDLRAAGCRTLVKDPAALLARYEASRREWPWNESGTSQVAKDDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY36</accession>
    <name>Q1CY36_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">hprK</name>
        <name evidence="13" type="ORF">MXAN_6565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556495.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6565"/>
    <dbReference type="EnsemblBacteria" id="ABF86734">
        <property type="protein sequence ID" value="ABF86734"/>
        <property type="gene ID" value="MXAN_6565"/>
    </dbReference>
    <dbReference type="GeneID" id="41363770"/>
    <dbReference type="KEGG" id="mxa:MXAN_6565"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052030_0_1_7"/>
    <dbReference type="OMA" id="AMNNRQK"/>
    <dbReference type="OrthoDB" id="391150at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="135"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="268"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF86734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="35347" checksum="64842777C8E3F604" modified="2006-07-11" version="1">MKSIRISQLLEDRDYDMRLSLVAGGGGLSRIVVSSRIQKPGLALAGFTEHLHPHRVQVFGNTEISYLATLPEARQRESLAQLFGEEELACVVVTKDLDIPQALVSACEGAGLALMKTPLLSSDFIMRVQTFLEEALTESSSLHGVLMDVFGVGILLLGKSGIGKSEIALDLVMRAHRLVADDIVDVTRRKGAVYGAGNPVIKHHMEIRGLGIINIKDLFGVAAIREQKKIELVIELQEWDPHQEYDRLGVEDRHLQIVGVDIPLSVVPVRPGRNMATIIEVAARNQLLKLQGHHSAREFAERLNRAIAEGAMRRTLGEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY68</accession>
    <name>Q1CY68_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative PTS system, mannose/fructose/sorbose family, IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556463.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6533"/>
    <dbReference type="TCDB" id="4.A.6.1.12">
        <property type="family name" value="the pts mannose-fructose-sorbose (man) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89219">
        <property type="protein sequence ID" value="ABF89219"/>
        <property type="gene ID" value="MXAN_6533"/>
    </dbReference>
    <dbReference type="GeneID" id="41363740"/>
    <dbReference type="KEGG" id="mxa:MXAN_6533"/>
    <dbReference type="eggNOG" id="COG3715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183048_0_0_7"/>
    <dbReference type="OMA" id="LWGMWPH"/>
    <dbReference type="OrthoDB" id="1567583at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="24392" checksum="868835962A4ADBC9" modified="2006-07-11" version="1">MSVVWTQVALAGLWGGLVALERKAFLQAMMSRPLVAATVMGALLDDVASGLAIGMLLELFFLGTANLGAALPENDTLAATGTSAAAATLSAATGAGSTPAIWSLAVLLFIGLGRVGRKGDRLLEGYTARLARVALASAEAGNITRAMRQNLWGMWPHFAVYGSLTALCALLGFFIEPLLQALPPVVVRGLAWAWPAMASVAAAIAAQGSHARRAPLFAGLGAAVVTASVVCVILLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYG8</accession>
    <name>Q1CYG8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cardiolipin synthetase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6431"/>
    <dbReference type="EnsemblBacteria" id="ABF91249">
        <property type="protein sequence ID" value="ABF91249"/>
        <property type="gene ID" value="MXAN_6431"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6431"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033743_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="29425" checksum="84B4033CC9ADAA50" modified="2006-07-11" version="1">MDEMQELEALIPKPGALGFSGSVERARHEMHGPFSLPPGPEAFSFALYQSTGVGLIPGHALELLENGAVFERMLADIRAAQSSVHVLVYIWRPCALSDRVVEALVERARAGVACRVVVDPVGSEEIRGDRDFDQKVEKVLTDAGVEVHYFRLLAGKVLGRLLGRSHQKLVIVDGRIGYTGGFGIWKVWEGDGLKPDEWRDTHSRVEGPEVRRMQLSFSRHWQESGGGLIPPSAFPEAEPAGPCAAGFIDSAGKLGLTDAERWTRCRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYJ8</accession>
    <name>Q1CYJ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6401"/>
    <dbReference type="EnsemblBacteria" id="ABF91716">
        <property type="protein sequence ID" value="ABF91716"/>
        <property type="gene ID" value="MXAN_6401"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6401"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="13"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="42923" checksum="FC9DF22B107CAE59" modified="2006-07-11" version="1">MAGGTRMTDEMRVVITGMGAVSPYGAGVPPLLDALAEGRSAIRPIDDFDVSGCGCKHGARVPRGSLSALTGSNNLRRAPRGTQYTMLATEEALQMAGHGPSTWNPERVGVFLGTYRAMAEVSQDIWHRIITSEPRFVQPLLFQETVTNAVASALSIRWGWRGTNYAISAGNACGFQVLALAAQALRSGRADALIAGTFDLFTTATHFDMDDIGVLSDANVSRPFDTRRDGYIMGEGAAVVVLETLASARARGATPLAEIAGLGVAHDGHAFGIHHPEGRGLASAMSQALRDAEASPEAVDYIAAASNSTQSLDRAEVAALKTVMGAAASTVPLSSVKGLMGEAESASDMFNLLACVGAVRGGGLPVQAGIEQPEFELNLVRQPRPHRPVRTALAHSYSFGGNAGAALVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZD7</accession>
    <name>Q1CZD7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556050.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6101"/>
    <dbReference type="EnsemblBacteria" id="ABF86717">
        <property type="protein sequence ID" value="ABF86717"/>
        <property type="gene ID" value="MXAN_6101"/>
    </dbReference>
    <dbReference type="GeneID" id="41363335"/>
    <dbReference type="KEGG" id="mxa:MXAN_6101"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_7"/>
    <dbReference type="OMA" id="PAITHQT"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="321"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="459" mass="51240" checksum="8BF3785207049EEF" modified="2006-07-11" version="1">MPSPTELHFDCGTLVAPTLPEDARLRALFQKDGRTGVYRAPAWHYREAVLRLRELGIPYEDKAKRFEPLELPLTSPIQPFPHQQQALEAWTRAGGRGLVELPTGAGKTLLAVLAIAHVKRPTLVVVPTLDLMTQWQGVLARHFSAPVGLLGGGVNDRQPLTVTTYDSAAMQTEFHGNRFGLLVCDECHHLPAPSYRFIAEGSLAPYRLGLTATLERADGGERVCEELLGPRVHRSDIRELQGEYLAPYEVKRVEVPLTPDEKARYDTARALYLGFVRRLSVPLSAPDGWARFLAQSQRSDEGRAAYRAYREQRRIALTSSGKQEVLWRILLEHRDDRVLVFTDDNETVYTLARRFLLPALTHHTPVPERKALLAAFASGELPVLLTSRVLNEGVDVPEARVGVVLSGSASVREHVQRLGRILRKRPGKRALLYEVCSAQTAESSISERRRQHGAYQEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZG4</accession>
    <name>Q1CZG4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556023.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6074"/>
    <dbReference type="EnsemblBacteria" id="ABF88425">
        <property type="protein sequence ID" value="ABF88425"/>
        <property type="gene ID" value="MXAN_6074"/>
    </dbReference>
    <dbReference type="GeneID" id="41363310"/>
    <dbReference type="KEGG" id="mxa:MXAN_6074"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_2_7"/>
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    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_A_M"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04120">
        <property type="entry name" value="DNA_lig_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_LIGASE_A1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="DNA_LIGASE_A3" evidence="6">
        <location>
            <begin position="307"/>
            <end position="435"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="60285" checksum="A003BD6B9DF6CCE2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ1</accession>
    <name>Q1CZQ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5987"/>
    <dbReference type="EnsemblBacteria" id="ABF91171">
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        <property type="gene ID" value="MXAN_5987"/>
    </dbReference>
    <dbReference type="GeneID" id="41363226"/>
    <dbReference type="KEGG" id="mxa:MXAN_5987"/>
    <dbReference type="HOGENOM" id="CLU_1426611_0_0_7"/>
    <dbReference type="OrthoDB" id="2120000at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="21112" checksum="6DDEDE146A6B8400" modified="2006-07-11" version="1">MLLGWGAGAIGVGAYIFLSPYLSPPAEPGNISSPTLAKLLNESIDAAIERMNPTHSPGLIPEAAANSRAFLKEVSEVVARCSKGRFEPGQKYNKLEYHLLRTDGVRYERIYTGIRCHEATLIYRAVFKDGRVAEAFTDGRERQYPVGQVRGAVGEFGKKVTWSDRDYHPARYYVPPPAQPTQADIAKQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY3</accession>
    <name>Q1CZY3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TrkA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5903"/>
    <dbReference type="EnsemblBacteria" id="ABF91629">
        <property type="protein sequence ID" value="ABF91629"/>
        <property type="gene ID" value="MXAN_5903"/>
    </dbReference>
    <dbReference type="GeneID" id="41363141"/>
    <dbReference type="KEGG" id="mxa:MXAN_5903"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796066_0_0_7"/>
    <dbReference type="OMA" id="FARHKND"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="4">
        <location>
            <begin position="262"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="365" mass="40869" checksum="8F7CCEF4346628C9" modified="2006-07-11" version="1">MKQSRRHFRANLRYLRALVRRFRTTLVLSAVLFLGGPLLFHWRFRGPGGDRIDFGEALHHTYFLLYGQPSLPYVDDWMVELLNLVIPPAGIALVADGVVRFAYLFFARHKNDKEWIEVVSETMKGHVVVCGAGRVGYRVVTQLREMGKDVVVVEKREDAAFVSALRDELVPLLIDDTRSPLCLPRTNVKDASAIVCATDDDLANLNIALDARKLNPDIRVVIRLFDDDLSGKVRETFKAEALSSSSLAAPAMALAAMDPRIVHSFHLAKHLMVVSLFEARLGLPGLTISDVRDRFGCLALSLQRNGEERLHPQGEEVIRPGDVLSLQASYPEYRRLRAFTHEAEPPLWSHHAPVAVVTPSSRKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D025</accession>
    <name>Q1D025_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
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</entry>
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            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="544" mass="56328" checksum="CBC6CEFA140FF65C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J7</accession>
    <name>Q1D0J7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002634498.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D0J7"/>
    <dbReference type="STRING" id="246197.MXAN_5688"/>
    <dbReference type="EnsemblBacteria" id="ABF91492">
        <property type="protein sequence ID" value="ABF91492"/>
        <property type="gene ID" value="MXAN_5688"/>
    </dbReference>
    <dbReference type="GeneID" id="41362933"/>
    <dbReference type="KEGG" id="mxa:MXAN_5688"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="DIMMPML"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="14226" checksum="2759F1B21EC8A97A" modified="2006-07-11" version="1">MSEKRRILLIDDSEITLAMEKAVLEARGYEVIATSTLMEFEKTLQTWRPDLILTDIHMPEAKGTDICRTLKNEYGTQDIPIVLFSSLPDDELSKLAEQVGADGSLSKVNGLEAMGEKIDELVQSILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0L6</accession>
    <name>Q1D0L6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5669"/>
    <dbReference type="EnsemblBacteria" id="ABF90141">
        <property type="protein sequence ID" value="ABF90141"/>
        <property type="gene ID" value="MXAN_5669"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5669"/>
    <dbReference type="HOGENOM" id="CLU_1775456_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="146" mass="15486" checksum="30C9F2673E64C908" modified="2006-07-11" version="1">MQREDGRGLSGGEVFRHVFVSAQDLHLAVVIAVAVVRVMQVTVHEIVHVVPVRRGRVATRGAVAVRGFMGTTGMLRRALRGVARVFGERALVRVVRVRVVQVPVVQIVHVVLVLDGGVATALGMDVVMALVRLVIHGSLPGGGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N1</accession>
    <name>Q1D0N1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555607.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5654"/>
    <dbReference type="EnsemblBacteria" id="ABF90359">
        <property type="protein sequence ID" value="ABF90359"/>
        <property type="gene ID" value="MXAN_5654"/>
    </dbReference>
    <dbReference type="GeneID" id="41362899"/>
    <dbReference type="KEGG" id="mxa:MXAN_5654"/>
    <dbReference type="eggNOG" id="ENOG5030UKJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1693593_0_0_7"/>
    <dbReference type="OMA" id="SNIMKVR"/>
    <dbReference type="OrthoDB" id="1789752at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="15939" checksum="28BE4529EA2B3EDE" modified="2006-07-11" version="1">MSNDSRIPTLTITHTVPRQTPQNDFGTVLARAANEVVRSGAGLVGGMIPGGPIVSAAVSSAKTVVSAVAPKTSGAGMPATADTGSAAGAGAAAGNQEAWDLLEAQKVLAAEGQKFNMAYLQLQNEMQKESREHTAVSNIMKVRHDSAKSAINNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N8</accession>
    <name>Q1D0N8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative type III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555600.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5646"/>
    <dbReference type="EnsemblBacteria" id="ABF90292">
        <property type="protein sequence ID" value="ABF90292"/>
        <property type="gene ID" value="MXAN_5646"/>
    </dbReference>
    <dbReference type="GeneID" id="41362892"/>
    <dbReference type="KEGG" id="mxa:MXAN_5646"/>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164516_2_0_7"/>
    <dbReference type="OMA" id="TMPWMLN"/>
    <dbReference type="OrthoDB" id="1939288at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="89" mass="9424" checksum="654AF6770ED7470D" modified="2006-07-11" version="1">MTQDVFLTLGREALLLMVMASLPPIGASLVVGFLSSLFQATTQLQESTLSVVPKLCAAVLALVLAGPWIAGQLTRFTHQLLMLISEVAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T1</accession>
    <name>MURC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">MXAN_5603</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555557.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0T1"/>
    <dbReference type="SMR" id="Q1D0T1"/>
    <dbReference type="STRING" id="246197.MXAN_5603"/>
    <dbReference type="EnsemblBacteria" id="ABF88226">
        <property type="protein sequence ID" value="ABF88226"/>
        <property type="gene ID" value="MXAN_5603"/>
    </dbReference>
    <dbReference type="GeneID" id="41362849"/>
    <dbReference type="KEGG" id="mxa:MXAN_5603"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_7"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000336846" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="472" mass="51743" checksum="3EE13FE4206D7773" modified="2006-07-11" version="1">MTRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMGATFFEGHRAQNLIQADVVVISSAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAVAGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAKLGKSELMVVEADESDGSFLHLHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEKRFVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAEEMDIPLETVRESLAEFGGVQRRFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRVVVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEERIHGATGDALADAVRAHGHRDVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Z4</accession>
    <name>Q1D0Z4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase, cbb3-type, CcoQ subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccoQ</name>
        <name evidence="2" type="ORF">MXAN_5540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555494.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5540"/>
    <dbReference type="EnsemblBacteria" id="ABF89347">
        <property type="protein sequence ID" value="ABF89347"/>
        <property type="gene ID" value="MXAN_5540"/>
    </dbReference>
    <dbReference type="GeneID" id="41362788"/>
    <dbReference type="KEGG" id="mxa:MXAN_5540"/>
    <dbReference type="HOGENOM" id="CLU_2955754_0_0_7"/>
    <dbReference type="OMA" id="QFYQGMS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008621">
        <property type="entry name" value="Cbb3-typ_cyt_oxidase_comp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05545">
        <property type="entry name" value="FixQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="60" mass="6838" checksum="AA36C429C0D51B1B" modified="2006-07-11" version="1">MYKQFYQGMSLTELPLFALVLFIAVFLGVVAWVFVARRSGDFDALARMPLSEQGEGRHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D181</accession>
    <name>Q1D181_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="4">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fpr</name>
        <name evidence="7" type="ORF">MXAN_5449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555407.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5449"/>
    <dbReference type="EnsemblBacteria" id="ABF86703">
        <property type="protein sequence ID" value="ABF86703"/>
        <property type="gene ID" value="MXAN_5449"/>
    </dbReference>
    <dbReference type="GeneID" id="41362708"/>
    <dbReference type="KEGG" id="mxa:MXAN_5449"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_3_0_7"/>
    <dbReference type="OMA" id="MICGSSA"/>
    <dbReference type="OrthoDB" id="707164at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="28215" checksum="DFFA391EEC5F0A62" modified="2006-07-11" version="1">MATGFTTERVLSVQHWSDRLFSIVCTRDSGFRFQNGQFVMMGLEVEGRPLMRAYSMASANYDDTLEFYSIKLQDGPLTSRLQKVAPGDQVLVGTKAVGTLTVANLRPGRHLWMLATGTGLAPFLSMVKDPETWERFERVTVVHGCRHVSDLSYSKFFEEVLPNDPYLGDLVRERLTYFPTVTREPFRNQGRITDLLRAKPLSPEHDRVVICGSHEMIKETATILEGFGFEEGDSHERGDFLIEKAFASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B5</accession>
    <name>Q1D1B5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5411"/>
    <dbReference type="EnsemblBacteria" id="ABF92671">
        <property type="protein sequence ID" value="ABF92671"/>
        <property type="gene ID" value="MXAN_5411"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5411"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_1_0_7"/>
    <dbReference type="OMA" id="TWVRYDG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13129" checksum="309857648A86130B" modified="2006-07-11" version="1">MNTPSGGPYQVMSWPKKDLQAHIAFMAGFATKLGETGELVAAEGLAGPDQAKRVRAGADGKPITDGVFPESKEFLAGYWIIEVDSPERAYAIAAEASAAPGLGGKPMNMPIEVRQVMSGPPPDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R2</accession>
    <name>Q1D1R2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555226.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87835">
        <property type="protein sequence ID" value="ABF87835"/>
        <property type="gene ID" value="MXAN_5259"/>
    </dbReference>
    <dbReference type="GeneID" id="41362536"/>
    <dbReference type="KEGG" id="mxa:MXAN_5259"/>
    <dbReference type="HOGENOM" id="CLU_1056994_0_0_7"/>
    <dbReference type="OrthoDB" id="701320at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188125" evidence="1">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="33501" checksum="74BD0FD7510FE443" modified="2006-07-11" version="1">MTIPNFFRASFISALVIGTAAPALAAPATPPAPVAEVGPDGVGMLFPSEPSGSSFYLGDGDPSDSEPFFNMKGDEATPGLEAGVPYWSTPGHRVTYASGKPAGKTVRLHLRPSGGEQSFTWRDGAIENGFIGSPDDLLNFEATVYVRVHEDNGTHHSMSWKMRGGQHTKPEVARSSCVGMDVPFGGVSPQAYRELDHPTYDHLSLTPYFDYQLQEGRWLGVKVVSYLVEGGTRNLLFLDTNPFDASGTPRNEFRLFTEWHDRDGESTGHYNRAATWAGLETTFRVDGWRRVDFAYPSAREIVPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W8</accession>
    <name>Q1D1W8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GatB/Yqey domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5202"/>
    <dbReference type="EnsemblBacteria" id="ABF89004">
        <property type="protein sequence ID" value="ABF89004"/>
        <property type="gene ID" value="MXAN_5202"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5202"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_2_7"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="18549" checksum="C925E1F2FFA3B74C" modified="2006-07-11" version="1">MSGALAPAVEVPLNNVLPSGAATMATLKERIDADLKDAMRSKNELTLSVLRMLKSAVKYKEVEPGASALDDAGVLTIIAGLIKQRRDSVEQFKTGGRPELAEKEEAEISILQNYLPKQLTADELAAEVRAAIAETGAKGPKDMGAVMKNLNAKIHGKAEGRAISEAVKSELAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D217</accession>
    <name>Q1D217_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sigma-54 dependent DNA-binding reponse regulator CrdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">crdA</name>
        <name evidence="10" type="ORF">MXAN_5153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555124.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5153"/>
    <dbReference type="EnsemblBacteria" id="ABF87417">
        <property type="protein sequence ID" value="ABF87417"/>
        <property type="gene ID" value="MXAN_5153"/>
    </dbReference>
    <dbReference type="GeneID" id="41362436"/>
    <dbReference type="KEGG" id="mxa:MXAN_5153"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_1_7"/>
    <dbReference type="OMA" id="NCAAVPH"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="139"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="498" mass="54481" checksum="8BDBD509CF57173F" modified="2006-07-11" version="1">MPASVLIVDDEKNILLTLSQSLQLAGYQTHLANSGQVALDVVSARPVDAVLMDVKMPDMDGLTALAKLTELKPELPVIMMSGHGTIDTAVKATQLGARDFLEKPIARERLLVALRNVLKHQAAMAELQELRAQLGRYDMVGSGPAMQRIFSLIQRTAPSEGRVLITGENGTGKELIARALHQHSKRKGQPFVKLNCAAVPHELIESELFGHEKGAFTGAVSVRRGKFELAHEGTLFLDEIGDMPQAMQAKLLRVLQEGELERVGGAETHKVDVRVVAATNKNLEAEIAAGRFREDLYYRINVVQIHSPPLRERREDLPDLIKTFLDEACAKNGRRPLTLSPDALAVMSAYDYPGNVRELRNLVERLAILCEGPIVTRTDALELLPRGRNVPPPAPVETPASPLPPPSPEAAVVLASSTPAPAIAAPVATEPPAPVGFRPRADRTFREQVEDAEREIIQHVLSHTHDNVTEAARLLDLERGHFYKKMKALGLRRGSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E0</accession>
    <name>Q1D2E0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555004.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5028"/>
    <dbReference type="EnsemblBacteria" id="ABF85906">
        <property type="protein sequence ID" value="ABF85906"/>
        <property type="gene ID" value="MXAN_5028"/>
    </dbReference>
    <dbReference type="GeneID" id="41362313"/>
    <dbReference type="KEGG" id="mxa:MXAN_5028"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836322_0_0_7"/>
    <dbReference type="OMA" id="KGRNETQ"/>
    <dbReference type="OrthoDB" id="1278090at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="38117" checksum="74C1196679A5E099" modified="2006-07-11" version="1">MLVLVLALAVGLAISLYFNLFAGPKHAALPSSSTSSSAPRAELVTDTQARAKAEAELQRKQKELDEQRTQLQDVKEQLKQAKRKLYEQKESDKSAQDLAKARAEVERNASTQLERTREELSHALVENQRLKAEMESKGRRPQPAPAAPIAAPATQVAAPAQEGEAVIAAVVPVVPTATETVPQERGQRRYRELNDADREKMERLEQAANKDRLRAVELEKELRRVKGRNETQQRVYAATKHDLDLSRDKYKALEKRLNRTLLERDLIRRAIKDLEKKTGMLADRTELTPEEVAASDQRTEETSRVRAEAEAQATPKTEAPADTEQQAPESAPADAESKPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F7</accession>
    <name>Q1D2F7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5011"/>
    <dbReference type="EnsemblBacteria" id="ABF90344">
        <property type="protein sequence ID" value="ABF90344"/>
        <property type="gene ID" value="MXAN_5011"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5011"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035903_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008256">
        <property type="entry name" value="Peptidase_S1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00839">
        <property type="entry name" value="V8PROTEASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="95"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="469" mass="49817" checksum="3A0F8A767365B34A" modified="2006-07-11" version="1">MLLDIPGSQLQQGPPSMQVILTHVRRKLFGVLLCSLSVACVQDSGPVTKGGDTSAPTDTLRQGVVYGVDDRKDYYAHSDATLKKFTRESTVALVDVADLDTSNPSSIGFFSQTLQEAQGLCSDQRFLNDPTAAFCSGTLIDNDLVLTAGHCVKGPLSCASTRFVFKYYRTGATTLEPVTSEDVFRCSRVVVRNASTVGGRQLDYAIVQLDRPVSALRAVPAPVRMDSVALSTTTQLAVIGSGSGIPFKIDSGGKVLASRASTLDFFVGDTDTFGGNSGSGVYAKIDGSYLLAGILVRGNKDYVKRIGPAGECYVVNVITSIGSCTDAICSAEAINYVRPAIDAYCAVATNTRLCPGQGPATPVTFDFATSGTNNATRNTVAQNVTLSAGETLYVGTAMVMYATARGDTYLRLDRYETSTNTYTGVANNDDAYDSLSYIRYTAKVAGTYRIRVGCARDSACAGRVSYIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Y3</accession>
    <name>Q1D2Y3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoquinoline 1-oxidoreductase, beta subunit</fullName>
            <ecNumber evidence="2">1.3.99.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iorB</name>
        <name evidence="2" type="ORF">MXAN_4829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554815.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4829"/>
    <dbReference type="EnsemblBacteria" id="ABF86529">
        <property type="protein sequence ID" value="ABF86529"/>
        <property type="gene ID" value="MXAN_4829"/>
    </dbReference>
    <dbReference type="GeneID" id="41362126"/>
    <dbReference type="KEGG" id="mxa:MXAN_4829"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013917_0_1_7"/>
    <dbReference type="OMA" id="AVDCGPQ"/>
    <dbReference type="OrthoDB" id="337328at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047121">
        <property type="term" value="F:isoquinoline 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="3"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="211"/>
            <end position="300"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86529.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="753" mass="80484" checksum="5002C452E0BF2A20" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D325</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86541.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="549" mass="58508" checksum="BABE5FD8AF558CF8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D376</accession>
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        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4735"/>
    <dbReference type="EnsemblBacteria" id="ABF89382">
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    </dbReference>
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    <dbReference type="OMA" id="YRYNFFY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF4105"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89382.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="415" mass="46198" checksum="31A3FFD8BFC436FC" modified="2006-07-11" version="1">MPPWGTGESQGEDLAILLVTFSPGDDVPSWWGHGSLVVEDRRRQMSRLYNYGMFSFDEAMLARFAMGRLEFWVGQSSVGGTFRFYQAEDRDVRVQELNLTPEQRVVVAKRLAENVLPENREYLYHHYNDNCVTRLRDMIDVATGGQLREADRAPGRMTLREHTRRYTSVNAPMSVLLDFMMNDEIDRPITKWEEAFLPDELETQVAALQVKGADGQTASLAAKSWNYYESSRRQRPPAAPPPWGPWILALGLALGGLAVGLAVWERQRGSRVARLLLGLENAVVGLALGLPGTALFIMGLVTDHTVTHRNENLFLANPLTLLALPFGVALTWGSQKARMRLFKVWTLLAALGVLGVVLKVLPPFDQDNWRLIALILPISLGMAGAFGLDRVLARLPRADRASAGRRDAVASLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3C4</accession>
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            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="gene ID" value="MXAN_4683"/>
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    <dbReference type="KEGG" id="mxa:MXAN_4683"/>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="32983" checksum="1F6604C053BC9756" modified="2006-07-11" version="1">MKTFLVVNPRSANGQTGKRWAEISAQVGRALGDFGHGFTQGGMDAARITRQALLDGYECIVAVGGDGTLNEVTNGFFEDGKALNPNAALGLIPRGTGGDFRRTFGWDLELASSLERLRSGTTEPFDVGQLEFIDNAGQPATRYFANIASFGVSAVVAQEVNQSSKALGGHLSFVWGTLKGLVKYSERQVRLSVDGGPEEVVSVTAVAVANGRYFGSGMFVAPDAVTHDGLFDVTIWSNYSLSDFVLKSKGVYNGSHVNWKGTRRLRCRTLRAEPVDGGDVFLDVDGETPGRLPCTMTLLPGAIRLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3D8</accession>
    <name>Q1D3D8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554661.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4669"/>
    <dbReference type="TCDB" id="1.A.30.2.4">
        <property type="family name" value="the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91342">
        <property type="protein sequence ID" value="ABF91342"/>
        <property type="gene ID" value="MXAN_4669"/>
    </dbReference>
    <dbReference type="GeneID" id="41361969"/>
    <dbReference type="KEGG" id="mxa:MXAN_4669"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_4_4_7"/>
    <dbReference type="OMA" id="LEKNVSW"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="73"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="25460" checksum="52542A486CE8354F" modified="2006-07-11" version="1">MSLNDILHYLRLGGVTLAMLIFASVAALIVAVERIIVLWGVGERSRALGETVNKHLLRGDVAAARTAAERSDAVAADIFLAGFDRMERSRTAGGAGIEAAVERERAQVALKLRRYLWILATIGSITPFVGLFGTVAGIMRSFKDLGLDVEAGGTGGSSAVMTGISEALVATAVGILVAVQAMVFYNYFQARLSRVLVELRLIGDEFVELLKERAAGLPPSEPMPPEPQAAPATRTDAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L2</accession>
    <name>Q1D3L2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SHMT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4593"/>
    <dbReference type="EnsemblBacteria" id="ABF90166">
        <property type="protein sequence ID" value="ABF90166"/>
        <property type="gene ID" value="MXAN_4593"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4593"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_7"/>
    <dbReference type="OMA" id="CFNLNPA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="6">
        <location>
            <begin position="27"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="456" mass="50078" checksum="B19F23755A52FCBE" modified="2006-07-11" version="1">MSLGLRSGGRSRGPLPQGASVDLEQISEILTRLEQHETRAARTLNMVPSENSMSALAKLPMLLDLHHRYFFNDGAEEEPWEFRGVQELSSLETELARPLLRELAGAEFVNVRALSGLNLMTLTLSALGGPPGSTVMLLSRAQGGHYATASVAARLGLKVCYATGPDAHTVDETQFAETLRAHQPGLVYIDQSNALFPLGVERLARAVQRDAPNTLLHIDASHWMGLVLGRQLPNPLTEGAHSFGGSTHKTFPGPQKAIFATNRRELFERFRATQQYMVSSHHFGATVSLALALLEFKHCRGEQYAAQVVLNTRRFGAALDRLGLALDGKERGFSAGHQLWIRTRASGVDAFTASQRLFDAGIRTNAYPSLPGIPEPVLRVGLNEPTYHGLMADDMEELAGLFVAAIFQTQPTEQIAGRVAALRARYRFPYRFPSDDPKLLEQAMRLVRLALTQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q0</accession>
    <name>Q1D3Q0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4555"/>
    <dbReference type="EnsemblBacteria" id="ABF87477">
        <property type="protein sequence ID" value="ABF87477"/>
        <property type="gene ID" value="MXAN_4555"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4555"/>
    <dbReference type="HOGENOM" id="CLU_525638_0_0_7"/>
    <dbReference type="OMA" id="AGVRPFH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="533" mass="57073" checksum="8B64EC05EE31AF72" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3W1</accession>
    <name>Q1D3W1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4493"/>
    <dbReference type="EnsemblBacteria" id="ABF91537">
        <property type="protein sequence ID" value="ABF91537"/>
        <property type="gene ID" value="MXAN_4493"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4493"/>
    <dbReference type="HOGENOM" id="CLU_1141597_0_0_7"/>
    <dbReference type="OMA" id="PIADWGN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="289" mass="31561" checksum="1ACC1569E3DDE062" modified="2006-07-11" version="1">MGRLATPLSPFRHVRRPRRLHRRAGQTRWTARRRAALRLHGRGAQAMILERTESRALAAIRFLDAETQRPLTEPITVAGHGLRFTRNVRGLHVVTDAPGFSDYAASFDLPNPLPAAAAFTLVASDPTRHYLARSFTLELPRDATAPPTGQPLPPDSVFRPVDVTLYPSPLMRPSARSAVVRLRVVDAHDTPLPGALVSLALADPEITRWGQSNERGDALILVPGIPIADWGNPEAPVHFTFSLAAAWAALPQPPDPDALSQDFHPLSSTLDVAAGEEVTTTIKLDWVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D414</accession>
    <name>Q1D414_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D414"/>
    <dbReference type="STRING" id="246197.MXAN_4438"/>
    <dbReference type="EnsemblBacteria" id="ABF86742">
        <property type="protein sequence ID" value="ABF86742"/>
        <property type="gene ID" value="MXAN_4438"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4438"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574793_0_0_7"/>
    <dbReference type="OMA" id="FFEKPFE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="457" mass="49961" checksum="53EE5A758AB3F775" modified="2006-07-11" version="1">MARLLIVEDNHELASLIVALAQSRGHDAKAAATGEAALESLGPGQHWDAALVDLLLPDIRGSEVLAALRAHGIPAIAVSGVYKGDRFAQEAVQVHGARSFFEKPFELITVMEALEQAGGVAPQPRAPPPIAESVLLDELLDTEDLIVLEEFPPEPSDAAEPLQVVPSTDPLPEPADTEHALPLPFGRREQVWSESTAPSTPPPPKRALPDWSLGGVLEDATVARLLNAYYEARHHGELKLQQGQVLKVVYFESGRVVYAASNLAAERFGRFCVRQGVLPEARLAEVAAFAKERGLRTGEAMLRMGLMDAAQREQLLVEQVKEIIWSTFTWKEGGYGFSAMRPRRTDLVKLSVFPGDLVLEGVAKTETLVTLRRHMPRSRRLFPTADAPYGLHELKLEGAQALVLAYADGSKTVEDLLALTDLPERQTLATLRGLELLGVLEERPDTPSRRHRISFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D490</accession>
    <name>Q1D490_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">MXAN_4360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554361.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4360"/>
    <dbReference type="EnsemblBacteria" id="ABF87925">
        <property type="protein sequence ID" value="ABF87925"/>
        <property type="gene ID" value="MXAN_4360"/>
    </dbReference>
    <dbReference type="GeneID" id="41361672"/>
    <dbReference type="KEGG" id="mxa:MXAN_4360"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_7"/>
    <dbReference type="OMA" id="QQYGMNA"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="369"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="451" mass="47768" checksum="7CBDE0649EDD65D2" modified="2006-07-11" version="1">MPRHDSATQLLTTTLQEAYTRLGLEGGSVLLAVSGGADSTALLMGTVLVAERLRLRVEVASLDHGLRPEAAEEARQVSVLAAARGLPCHVQALRLHPGVGIEARAREARYAALEALRLERGLDVVATAHTATDQAETLLMRLARGTALRGAVGIHEARPGLVRPLLSCTREEVVAFLAEQGVAYVTDPMNTDPVHFRTRVRLGVLPALSRAAGFAVEGHLAAFARVVAEDESLLASMADAAFDRLRLEDGALDAVGVRALEPALRRRVLARLVAGTEAAVDEATLARVQRAVAQGGTATLGRGYVLRATSGRVRCVRQVPSTPPAELRLEHAGSRGALAGTGWNFSVEFAPPPAGVLGLALGDGTRWPLTVRTRRPGDRVCTAGGQRKLQDVLVDLRVPAEARATRPVVADAEGQVLWLPGLWSPVAPRAAAREYLWAVPPGSSIQRTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H6</accession>
    <name>Q1D4H6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554275.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4272"/>
    <dbReference type="EnsemblBacteria" id="ABF92572">
        <property type="protein sequence ID" value="ABF92572"/>
        <property type="gene ID" value="MXAN_4272"/>
    </dbReference>
    <dbReference type="GeneID" id="41361587"/>
    <dbReference type="KEGG" id="mxa:MXAN_4272"/>
    <dbReference type="HOGENOM" id="CLU_2437743_0_0_7"/>
    <dbReference type="OMA" id="SGWMARS"/>
    <dbReference type="OrthoDB" id="2147299at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="90" mass="9580" checksum="1B6625F39DF33858" modified="2006-07-11" version="1">MKTAVAFLAGVASGWMARSTVDNSRGAVVSVATAAFDLVAWTRRVIATEREYLSDLVAEARSRANLHQAHSRRAADSGARPVADSREGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4N8</accession>
    <name>Q1D4N8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnr</name>
        <name evidence="10" type="ORF">MXAN_4210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554213.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4210"/>
    <dbReference type="EnsemblBacteria" id="ABF87848">
        <property type="protein sequence ID" value="ABF87848"/>
        <property type="gene ID" value="MXAN_4210"/>
    </dbReference>
    <dbReference type="GeneID" id="41361527"/>
    <dbReference type="KEGG" id="mxa:MXAN_4210"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_8_0_7"/>
    <dbReference type="OMA" id="CTYNEVQ"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="723"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="811"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1182" mass="130306" checksum="5B5ECFE6C9874F1A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5C0</accession>
    <name>Q1D5C0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553983.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3973"/>
    <dbReference type="EnsemblBacteria" id="ABF90717">
        <property type="protein sequence ID" value="ABF90717"/>
        <property type="gene ID" value="MXAN_3973"/>
    </dbReference>
    <dbReference type="GeneID" id="41361305"/>
    <dbReference type="KEGG" id="mxa:MXAN_3973"/>
    <dbReference type="eggNOG" id="COG5285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048953_6_0_7"/>
    <dbReference type="OMA" id="AFSACYM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="28912" checksum="857384D60B8B70F2" modified="2006-07-11" version="1">MLCVDVERFDIRPALAHYAEHGYAKLGRVLGDEGLDALRERADDLMLGRVVHPGLFFQPDATTGRYEDAPLGLGWQGPSLDYRKLEKLEKDPRFLAWMENPLFERIARALIPGDIVLYRAILFHKGKAGGSNLPWHQDGGRLWGLTHEPELQIWTALDDAPEDGGCLEVVPGSHRGGLVTPLGGVIPPDAVAAADAESRVLSLPARAGEAILVHNHLWHRSGRGRPGLRRRAFSACYMDAVVRCLRKKKAPRVFPPMFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D676</accession>
    <name>Q1D676_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553678.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3660"/>
    <dbReference type="EnsemblBacteria" id="ABF87782">
        <property type="protein sequence ID" value="ABF87782"/>
        <property type="gene ID" value="MXAN_3660"/>
    </dbReference>
    <dbReference type="GeneID" id="41360996"/>
    <dbReference type="KEGG" id="mxa:MXAN_3660"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076645_1_1_7"/>
    <dbReference type="OMA" id="SPGIWLK"/>
    <dbReference type="OrthoDB" id="1966598at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="20365" checksum="C57E8DF5691D61D5" modified="2006-07-11" version="1">MDAPVIAFRGAAEFEAWLHAHADAPSGVWLKLAKKGTDIPSLTDDEAVDVGLCFGWISGQRRSLDARFYLQKYVPRRPRSRWSCVNVRKVEALLRAGRMRPSGLAEVEAAKADGRWAAAYASQKNATVPEDLTVALSASPRAARAFEALGKTRRYGLILKVMTARTEKGRASQVRRVVAELDAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D682</accession>
    <name>Q1D682_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">poxB</name>
        <name evidence="6" type="ORF">MXAN_3654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553672.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3654"/>
    <dbReference type="EnsemblBacteria" id="ABF88296">
        <property type="protein sequence ID" value="ABF88296"/>
        <property type="gene ID" value="MXAN_3654"/>
    </dbReference>
    <dbReference type="GeneID" id="41360991"/>
    <dbReference type="KEGG" id="mxa:MXAN_3654"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_7"/>
    <dbReference type="OMA" id="AANWYAR"/>
    <dbReference type="OrthoDB" id="351701at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="387"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="594" mass="65082" checksum="B66D72C21583D2F2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6I4</accession>
    <name>Q1D6I4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">MXAN_3546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3546"/>
    <dbReference type="EnsemblBacteria" id="ABF88169">
        <property type="protein sequence ID" value="ABF88169"/>
        <property type="gene ID" value="MXAN_3546"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3546"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_7"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="94" mass="10164" checksum="8562232C08D6E648" modified="2006-07-11" version="1">MDVEQLLNYLARALVDHPDQVSLRISEAEGARLFELKVSAEDVGKVIGRDGRTVNALRTLLNAAAQKSGQKVRLEILDDRRNAAGAPVAPDSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N4</accession>
    <name>Q1D6N4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553525.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3495"/>
    <dbReference type="EnsemblBacteria" id="ABF92700">
        <property type="protein sequence ID" value="ABF92700"/>
        <property type="gene ID" value="MXAN_3495"/>
    </dbReference>
    <dbReference type="GeneID" id="41360840"/>
    <dbReference type="KEGG" id="mxa:MXAN_3495"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043118_0_0_7"/>
    <dbReference type="OMA" id="FSLMHDC"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="38085" checksum="DC03D571397A0689" modified="2006-07-11" version="1">MDSATRSSAFTSLSRDAERNLIARTRPFAAQDTRRSWWEVGTTFAALLGAIALAALPSWWPLRIVGSVVQALALIRSFILVHDYLHGSLLSGSRIAKALFHTHAVLLLTPPRVWTESHNHHHANTARLAASASGTFTTWTAQQWREATALERLAYVVERHPLVMIFAYPLAFLGGLCIVPFVKHPLRYWSAGFAVLLHVTISAAVFHFGGLGVYLTAMVLPLSLGYALGAYLFFSQHNFPDVALREDPDWTHASAALEASSYLACGPVMAWFTGNIGYHHVHHLNPRIPFYRLPEAMAAIPELQNPRTTTLHPRDVLACLRLNVWDGKRGRMVRFRDVPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X6</accession>
    <name>Q1D6X6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3400"/>
    <dbReference type="EnsemblBacteria" id="ABF91069">
        <property type="protein sequence ID" value="ABF91069"/>
        <property type="gene ID" value="MXAN_3400"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3400"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010457_4_0_7"/>
    <dbReference type="OMA" id="ECEAVVW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02231">
        <property type="entry name" value="TIGR02231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="195"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="510" mass="56173" checksum="6FAEAA1D7AB48971" modified="2006-07-11" version="1">MVKVTVLEDRALVERRGEIPLSVGTQRLVIQGLSPLAVDRSLQAKVAGGTISQARIRRATKPQPPEAEREHRTALGKRVAELEQELRRVVADETRLAARLRLLDTARADVHRAISEQAGAGQSRPETWREQLETVRREQLSADSALREAERRTLRLREQFDEARASQTAVELLEPTVDTQAELEVGHPTGGPATLSVTYLVPCTAWRPSYRATLSREASGESVTLECEAVVWQRTGEEWKDVELAFSTARPTLGATPPRLQEDRLWLRDKTEREKQVVEVAIREEVIQTAGEAGAARRDDALPGMDDGGEPLTVTAPHRASVPPDGEPYRVPLFQFTAPAASELVAMPEQSPLVHRVARFDNTGPTVLLAGPVKLVRTHGYVGRAQLRFTGKGERVKLGFGSEDALRVARTEDVGRETSRLTGRKVTTHKVRLFLSNMGAKSVPVAIEERIPVSEVESVEIQLQRESTKPAPARVSEDGIVRFELTASPRSQQELAMDYVVTSAAKVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X9</accession>
    <name>Q1D6X9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3397"/>
    <dbReference type="EnsemblBacteria" id="ABF86637">
        <property type="protein sequence ID" value="ABF86637"/>
        <property type="gene ID" value="MXAN_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3397"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054121_0_0_7"/>
    <dbReference type="OMA" id="MESTFVD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="69"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="33917" checksum="97BA066093C9BEEF" modified="2006-07-11" version="1">MRTSWPSRGLSSRVSSMPRIVSVSMLTEVQAGPYTVRGVSVGGVYTSLQVPELDVVLDVGLPIRSFCGSDRIFLSHAHPDHASGLGSLLGIRRLIGKGAPQVFLPAEIEENVQASLAVMSRLHHTSMEVHTVPMLPGDVRPLGQGLFVRAFRTHHPVPSLGYQFFRRVAKLRLEHQSLPPQEIARRRQAGEALFDEVERLELAYATDTLSRVLDTEPGLFDSRVLILECTFVDARHSVQDAQAKAHLHVDELLARADQFRNEALVLMHFSQALPPESVHATLRARLPPSLAERVRVFAPEAGRWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7B4</accession>
    <name>Q1D7B4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553305.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3260"/>
    <dbReference type="TCDB" id="2.A.66.12.1">
        <property type="family name" value="the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92525">
        <property type="protein sequence ID" value="ABF92525"/>
        <property type="gene ID" value="MXAN_3260"/>
    </dbReference>
    <dbReference type="GeneID" id="41360612"/>
    <dbReference type="KEGG" id="mxa:MXAN_3260"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539592_0_0_7"/>
    <dbReference type="OMA" id="GLMPQFI"/>
    <dbReference type="OrthoDB" id="389868at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="506" mass="53717" checksum="5644E56110F46CF5" modified="2006-07-11" version="1">MSGGSTSAASGGSFLGRAGPLVLARLFTAGLTLSIPLVLARVLNLDDYGTYYQLFLIATTLYYVLPFGVVQSLYYFLPRADAKRPFLGQTLLFMSAMGLVGAGAVWALLGYVAGWFSNPALAEYRLPLAAYTAFLLGSFPLEVSLTSQGRTKASAVVYLISDAVRASVMVVPPLLGASLYGMMMAVAAFAGLRYLATWVVSLRGATGPWVDGQRFREQLTYAAPFGAAMLLAIPQQNAHLYAVAGAVAPALYALYRVGCFQLPVVDLLYTPTSEVLMVRLGELEREGRLEEGVEAFREAAGKLAYFFLPFAAFLFSAAPEFIGAMFGEKFLPAVPVFRISVLGVVLSILPMDGTLRARGQTRAIFASYAVKAAVTVPLVWLGVKHFGLMGGIGSWAVAEVVGKAMLLARVPAALSTPERKLGVADVIPWQSLGKATLAACAAAAAVFVLRAGAHGAWAHLPTGFLWRVLPLAVAGALFFIGYLVVLHFTGVRPLSLIAGLRARRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H8</accession>
    <name>Q1D7H8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553241.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3194"/>
    <dbReference type="EnsemblBacteria" id="ABF93112">
        <property type="protein sequence ID" value="ABF93112"/>
        <property type="gene ID" value="MXAN_3194"/>
    </dbReference>
    <dbReference type="GeneID" id="41360549"/>
    <dbReference type="KEGG" id="mxa:MXAN_3194"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086500_5_1_7"/>
    <dbReference type="OMA" id="DGACAVH"/>
    <dbReference type="OrthoDB" id="2019103at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="14895" checksum="EDE71B27AD7AADD1" modified="2006-07-11" version="1">MAPVLRTTPPGHDVILYDGHCRLCGGAARQLQRLLGGTGTRLRSFREDGVLAAFPGVTADRCERALQLVLPDGAVVEGLEAIVLALGRRPLGRLLRVYYVPGLRQLLDALYRVVARHRFRIAGRQCPDGACVVHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7R4</accession>
    <name>Q1D7R4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein transporter, outer bacterial membrane secretin (Secretin) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553156.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D7R4"/>
    <dbReference type="STRING" id="246197.MXAN_3106"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91990">
        <property type="protein sequence ID" value="ABF91990"/>
        <property type="gene ID" value="MXAN_3106"/>
    </dbReference>
    <dbReference type="GeneID" id="41360467"/>
    <dbReference type="KEGG" id="mxa:MXAN_3106"/>
    <dbReference type="eggNOG" id="COG4964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017952_2_0_7"/>
    <dbReference type="OMA" id="DWSTIGN"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187970" evidence="2">
        <location>
            <begin position="26"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="T2SS-T3SS_pil_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="3">
        <location>
            <begin position="165"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="482" mass="51881" checksum="7DCD06739C6B4050" modified="2006-07-11" version="1">MFTRITHAAALGALIALVAGGSALAQDGTTVSLGVGSQKVITIPGLSRVALGDPSVAEVKTLGSGQLLITGQAEGKTTLLVWKSSGQRVSYLVAVRKQDPNEVISEIKRLLGEIEGVSVRMVGDRIYLDGQAYTTQDADRIEQVVGLYPNVKSFVKIAPNAKKLVAQNLNAAFQKAGLKNVQANVVGATIFLEGSVESQQDLQKAELITKAIGEKVENLLVVGIKRMILSEVQFVEIRRNSRDRYGIRYPTDITGTATAIASISQELFPGTFGSGVSTLTLNANADFSFGFQGNDGYGRLLAQPKLVCASGEKAEFLAGGEVPIPLITNNQFTVEFKKYGVILNLRPTADRNGNIQTEIEAEASEIDTSVAVSFGGSASIPGFRTRKVKTNVTVRHGETIVLSGVFSHDEQKSVSKLPGLGHIPIIGELFKSRGFDSTKRELVIFVTPRIVNPDSDKVRTIIEDVKSRYKQARSEVNFNIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7S9</accession>
    <name>Q1D7S9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3091"/>
    <dbReference type="EnsemblBacteria" id="ABF92580">
        <property type="protein sequence ID" value="ABF92580"/>
        <property type="gene ID" value="MXAN_3091"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3091"/>
    <dbReference type="eggNOG" id="COG1297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_2_1_7"/>
    <dbReference type="OMA" id="AGNQVRQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="606" mass="61891" checksum="4C43F04BB0AD0393" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U2</accession>
    <name>RPOC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">MXAN_3078</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553128.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7U2"/>
    <dbReference type="SMR" id="Q1D7U2"/>
    <dbReference type="STRING" id="246197.MXAN_3078"/>
    <dbReference type="PRIDE" id="Q1D7U2"/>
    <dbReference type="EnsemblBacteria" id="ABF88775">
        <property type="protein sequence ID" value="ABF88775"/>
        <property type="gene ID" value="MXAN_3078"/>
    </dbReference>
    <dbReference type="GeneID" id="41360440"/>
    <dbReference type="KEGG" id="mxa:MXAN_3078"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_7"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="rpoC_TIGR"/>
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    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
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    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000308865" description="DNA-directed RNA polymerase subunit beta'">
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            <begin position="1"/>
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            <position position="72"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <position position="85"/>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="88"/>
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            <name>Zn(2+)</name>
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            <position position="461"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <name>Zn(2+)</name>
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        <source>
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        </source>
    </evidence>
    <sequence length="1403" mass="156314" checksum="A31ADEAD93A3A3C2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I9</accession>
    <name>TPIS_MYXXD</name>
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        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
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        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
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        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">MXAN_2817</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89274">
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        <property type="gene ID" value="MXAN_2817"/>
    </dbReference>
    <dbReference type="GeneID" id="41360193"/>
    <dbReference type="KEGG" id="mxa:MXAN_2817"/>
    <dbReference type="eggNOG" id="COG0149">
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    <dbReference type="HOGENOM" id="CLU_024251_2_3_7"/>
    <dbReference type="OMA" id="QEVCGAI"/>
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    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000307515" description="Triosephosphate isomerase">
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            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="256" mass="26804" checksum="1AB2864297073921" modified="2006-07-11" version="1">MATARRRKIVAGNWKMNKSVPEALALVRDLRGQVASLGDTVEVVVAPPFVALQPLHVALEGAPLALAAQNCHWESSGAFTGEISAPMLAELGCAYVIVGHSERRQLFGDTDEQVNKRAKAVRAAGMTPIICVGETLAEREANQTLAVVERQVRGALEGFGAKEVAGFVLAYEPVWAIGTGRNATAAQAQEVHAAIRGLVERLYDGETAGRVRIQYGGSVKPDNAAELLGQPDVDGALVGGASLKAGDFAAIVKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q7</accession>
    <name>Q1D8Q7_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2749"/>
    <dbReference type="EnsemblBacteria" id="ABF90979">
        <property type="protein sequence ID" value="ABF90979"/>
        <property type="gene ID" value="MXAN_2749"/>
    </dbReference>
    <dbReference type="GeneID" id="41360126"/>
    <dbReference type="KEGG" id="mxa:MXAN_2749"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144137_0_0_7"/>
    <dbReference type="OMA" id="LWREDAW"/>
    <dbReference type="OrthoDB" id="2036595at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16688" checksum="426653C2ACDD5447" modified="2006-07-11" version="1">MVLVSPMLSEVEPMFSIEIRLRSDAAVAAALSRRYAREHGLTAQASAEVAVVVSELATNLARHAGGRGWVELWLEAEWLFIRSRDRGPGMEDPSRFFAGREGRPSPLPGDSLGEGGAAVRRLTDDVQVANREGGGFEVLARKRVVVQAKRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R0</accession>
    <name>Q1D8R0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2746"/>
    <dbReference type="EnsemblBacteria" id="ABF89089">
        <property type="protein sequence ID" value="ABF89089"/>
        <property type="gene ID" value="MXAN_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2746"/>
    <dbReference type="HOGENOM" id="CLU_389724_0_0_7"/>
    <dbReference type="OMA" id="AVEANVF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="708" mass="63393" checksum="A416EA814432AE4E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Z9</accession>
    <name>HEM1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="1">GluTR</shortName>
            <ecNumber evidence="1">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemA</name>
        <name type="ordered locus">MXAN_2655</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552725.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8Z9"/>
    <dbReference type="SMR" id="Q1D8Z9"/>
    <dbReference type="STRING" id="246197.MXAN_2655"/>
    <dbReference type="EnsemblBacteria" id="ABF92563">
        <property type="protein sequence ID" value="ABF92563"/>
        <property type="gene ID" value="MXAN_2655"/>
    </dbReference>
    <dbReference type="GeneID" id="41360031"/>
    <dbReference type="KEGG" id="mxa:MXAN_2655"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_7"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000004653" description="Glutamyl-tRNA reductase">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <sequence length="441" mass="46681" checksum="DD574763161FD643" modified="2006-07-11" version="1">MELICIGLSHRTAPLTVRERLALPESRQVDVLQRLAQAPVEALWVSTCNRVEVYLFAPDAAMARQRALMELQVLGGVEALEHLYEHQGEAALVHLFRVACSLDSMVLGEAQILGQVKEAFERGQGAGAVRGELMRACAAAFSCAKRVRTETAIGRAATSMAAAAVQLASKVFDGLAGKTVLVVGAGEMGELAARHLKQAGASKLYVTNRTLSRAEALAAEVGGQARPFEELLGLVAAADVVVCSTASQAPLFTRDNVGALGRGRRGRPLFMVDLAVPRDIDPAVGTLDWVHAYDVDDIQKFVADNAAARAEEAQKAGVLVAQEVARFVKERALREGTPVLARLRQRAEAIARSEVERTLGALGDGLNEKQRKSIEAMGRAIVNKLLHEPTARLRAVGPEGEGNRLAGAAAELFGLLEEEVGTAAAAPSVMAAPVQVATGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y2</accession>
    <name>Q1D9Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2321"/>
    <dbReference type="EnsemblBacteria" id="ABF87120">
        <property type="protein sequence ID" value="ABF87120"/>
        <property type="gene ID" value="MXAN_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2321"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058031_0_0_7"/>
    <dbReference type="OMA" id="IASCSKW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188550" evidence="2">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="398" mass="41039" checksum="DD6C2BF22B88FC1A" modified="2006-07-11" version="1">MKGADAKMTGMLRTLLVVLGVVLAACGESDAPTPDGGASPPAPDAGVPQPDAGSPLDDAGTPEPDAGSPWATVTAVLEARVAEAGASVPGLGLAVYDAQDRKVYEHIVGDFAPDRRVAVASASKMVSGTLLFELIRQGRLSLDSTTGQVLGWTGNKAGITLRHLLSFTSGLQPSHLCTFQSGITLADCVASIAQTPQVAAPGARFDYGSTHLQVAARMAEVSTGKTWNALFTETLAQPLGLPSGVTYFTAPNHPLGTTNPLVAGGLRASMNEYAPLLALVFHRGTHPGGVIGTPELFDAQAVEPFPGVVVGNSPAADMGLDLRYGLTAWLECPTPAQGCAVISSPGAFGWTPWVDREAGYYAVLGMHLQRDDPGAGVVSFAMHLSTEVKPLIRAALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA02</accession>
    <name>Q1DA02_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552376.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92321">
        <property type="protein sequence ID" value="ABF92321"/>
        <property type="gene ID" value="MXAN_2301"/>
    </dbReference>
    <dbReference type="GeneID" id="41359688"/>
    <dbReference type="KEGG" id="mxa:MXAN_2301"/>
    <dbReference type="eggNOG" id="ENOG5032Z83">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074087_0_0_7"/>
    <dbReference type="OMA" id="FVVHFTK"/>
    <dbReference type="OrthoDB" id="1776699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021223">
        <property type="entry name" value="AbiGi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10899">
        <property type="entry name" value="AbiGi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="36274" checksum="2B79FCEAD0185123" modified="2006-07-11" version="1">MDGHTAAVRGPGPPPRSAALRPLPRRLPQPGCRLKRLLPPGGFPAWQSGATHCAGSPRPPEYKTGRRGVPRVVRVASPRSVRDIACGVGMMLGYQTNPQWRDMSDFVVHFTKPGPPYRDAYQNMMSILGARTLIPGAEGFGIARREPAVAERHRSVCFSEIPLDQLARLVQRRSLYGIGFSKTYILSQGGGPVWYVQYASPAHLALKHQVERALAAPSPLQEPIWSMTPFVDIQGDHHNAPYSYRFDWEREWRVPGLLRFTEYDVAALFLPEELHDTAREFFTWAVREKAGPGYFCPCLDPLWKSDQIAEALAKHASDSVRLKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA15</accession>
    <name>Q1DA15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="5">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thiD</name>
        <name evidence="5" type="ORF">MXAN_2287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.7" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2287"/>
    <dbReference type="EnsemblBacteria" id="ABF92912">
        <property type="protein sequence ID" value="ABF92912"/>
        <property type="gene ID" value="MXAN_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2287"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_3_7"/>
    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="4">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="28062" checksum="9DE01E2660FABCCF" modified="2006-07-11" version="1">MAAMETSKSVATALTIAGSDSGGGAGIQADLSTFAFHRVHGTSALTAITAQNTQGVTRVDVMAPEAVAAQIDAVASDIGAGAVKTGMLVNPAIITTVAQRLRALGLGPLVVDPVMVSRAGARLIDDAAVGALKELLLPLATVATPNRHEAELLAGMKLETLEDMREAARRIHRLGPKAVLVKGGGMTGALRGTDVWFDGERLETLHLRAVDTRNTHGTGCTLSAAIAAHLALGQPPLEATRRAKDYVTAALEHPLPLGKGPGPFSHFFPLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA28</accession>
    <name>Q1DA28_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP transporter solute receptor, TAXI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552350.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2274"/>
    <dbReference type="EnsemblBacteria" id="ABF91296">
        <property type="protein sequence ID" value="ABF91296"/>
        <property type="gene ID" value="MXAN_2274"/>
    </dbReference>
    <dbReference type="GeneID" id="41359662"/>
    <dbReference type="KEGG" id="mxa:MXAN_2274"/>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030939_0_0_7"/>
    <dbReference type="OMA" id="AVNRMKM"/>
    <dbReference type="OrthoDB" id="626477at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="50900" checksum="9CE091FEA26C2C21" modified="2006-07-11" version="1">MKKDSLKARLRRTLRWDLWMTLGPALVIVSIAFAVTFYFVKPAPPKKVVIAAAGDEGGFRYFARKYQEILAKHGVTVEIRPTDGSLTSIKLLEDERSGVDVAFVQSGTSDATKAPHVVSLGSLSYVPLWVFYRGPTIDDLNALQGKRIVVGPEESGTRALSMKLLEANGVGAAPTELLNLGRDEAIEQLKQGKVDAVFIVSPAESPPVQRLARVPDIHLLSFSRGEAYVRRYPYLSRHVLPRGVLDLAADVPGHDVVMLAPTANLVATDALHPALAYLLMRAASEVHGKAGILDRTGEFPAALEAGFPFSSEARRYYESGVPLLHRYLPFWAANLVDRLWVMLVPFIAVLVPLGRVAPALYQWRVRSRIFRWYARLKEIELQLEEGPGREMLEEMLRRLDEAEREVNRIPMPLAYAENLYFFREHVDVVRRRLTRRIAESGEPSSEVLTAREKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA92</accession>
    <name>Q1DA92_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrite reductase (cytochrome; ammonia-forming)</fullName>
            <ecNumber evidence="2">1.7.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_2209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:13089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c-552 family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552286.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2209"/>
    <dbReference type="EnsemblBacteria" id="ABF86439">
        <property type="protein sequence ID" value="ABF86439"/>
        <property type="gene ID" value="MXAN_2209"/>
    </dbReference>
    <dbReference type="GeneID" id="41359598"/>
    <dbReference type="KEGG" id="mxa:MXAN_2209"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035040_1_0_7"/>
    <dbReference type="OMA" id="MHAPDVM"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042279">
        <property type="term" value="F:nitrite reductase (cytochrome, ammonia-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00548">
        <property type="entry name" value="NrfA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003321">
        <property type="entry name" value="Cyt_c552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30633">
        <property type="entry name" value="PTHR30633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02335">
        <property type="entry name" value="Cytochrom_C552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000243">
        <property type="entry name" value="Cyt_c552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="494" mass="55458" checksum="07BB4765B8C6E901" modified="2006-07-11" version="1">MTEPEKQRRFSGVKLVIAVAVAAALAAAGVTALLVNIMERKQEAKNPFYRVVELDDTITDPEVWGRNFPLQYDSYKRTVDQQRTRYGGSEAVARTPSQADPRTVVAQSRLEEDPRLVTMWSGYAFATDFREERGHAHMLDDQVYTERQHVTQQPGTCIHCHASVYVPYKKLGDGDLIKGFEKMNQMPFMEARKLVEHPVSCIDCHDPTTMQLRVTRPGFIEGIAALKASQGVPNFRVNQDATRQEMRTYVCGQCHVEYYFKGKEKRLTYPWAKGINIDQIMAYYDEDGHSDWTHELTGAKVLKAQHPEFEMYNQGIHAKSGVACADCHMPFMREGAMKVSDHQVRSPLLNINRACQTCHKWSEAELLQRAETIQTRTFETRNIAMDALVDLIHDIEAAQKAGQSEEALAKARDLQKRAQFYLDFVEAENSMGFHADQEAVRILSNSINFSRLGQNALRPSGGASTSPTTRPQGAPAPLTPVSTDGAGETQQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR3</accession>
    <name>Q1DAR3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552115.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2031"/>
    <dbReference type="EnsemblBacteria" id="ABF88917">
        <property type="protein sequence ID" value="ABF88917"/>
        <property type="gene ID" value="MXAN_2031"/>
    </dbReference>
    <dbReference type="GeneID" id="41359441"/>
    <dbReference type="KEGG" id="mxa:MXAN_2031"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697957_0_0_7"/>
    <dbReference type="OMA" id="VNADCNL"/>
    <dbReference type="OrthoDB" id="522872at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006796">
        <property type="entry name" value="Dickkopf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026435">
        <property type="entry name" value="Myxo_Cys_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04706">
        <property type="entry name" value="Dickkopf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04201">
        <property type="entry name" value="Myxo_Cys_RPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188441" evidence="2">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Dickkopf_N" evidence="3">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="40621" checksum="7F9685545763B1D6" modified="2006-07-11" version="1">MRNTPIRSLMWLPLLAVLAVLPGCIVHGEDDWYDDSDDDICYCSSDKDCSTGESCRSGVCRTVPPGSGACSSSLDCPGSQICINSVCSQFCSRDSDCGSGQRCDKNYCVGNGGTRPDAGSDGGTRPDSGTDGGTRPDAGSDGGTRPDAGVDGGAPQQCRVNMDCGAGNYCINNQCIRGCYDDSWCDAKDTCVSGLCRPRPVDPNTCSTAADCSGGKDCVDGQCRAACDSTTQCPDDYSCQIGYCMPIPDGGQCRANCECPAGQVCFNGKCKSPQPDPGQTCVANCDCPSGDVCTNGYCRPPAPPPDAGTGTACQANCDCPSGEVCSNGQCKVPPPPPVQDAGTSTPVCRANCECPSGQVCTDGVCKPVNTGSGNSCHATCECPAGERCIDNVCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAW4</accession>
    <name>Q1DAW4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FRG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1974"/>
    <dbReference type="EnsemblBacteria" id="ABF91271">
        <property type="protein sequence ID" value="ABF91271"/>
        <property type="gene ID" value="MXAN_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1974"/>
    <dbReference type="eggNOG" id="ENOG502Z9DH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050026_1_1_7"/>
    <dbReference type="OMA" id="PNLDACD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014966">
        <property type="entry name" value="FRG-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08867">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00901">
        <property type="entry name" value="FRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FRG" evidence="1">
        <location>
            <begin position="28"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="32379" checksum="B5FD20908BAB123B" modified="2006-07-11" version="1">MLEQRIGTWLELQDALFAGSWSEVLGRHRSTFVFRGMPQVTNDLSTALNRKGLFVRKEKDLLRAFRKYARSYSPQPVESVWDWLALAQHHGLPTRMLDWTFSPYVALHFLTENPERYGEDGMVWCVDYRQTNRHLPRRLKTLLQREGADVFTGEMLATTASDLSTFDHLAKHPFVLFLEPPSLDARIVNQFALFSVMNGPELRLDTFLEAQVDGVRKLIIPAALKWEVRDKLDQSNITERVLFPGFDGLSRWLRRYYGPRAPAHASDAPPVRKRRRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAX7</accession>
    <name>Q1DAX7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1961"/>
    <dbReference type="EnsemblBacteria" id="ABF89463">
        <property type="protein sequence ID" value="ABF89463"/>
        <property type="gene ID" value="MXAN_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1961"/>
    <dbReference type="eggNOG" id="COG2912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063810_1_0_7"/>
    <dbReference type="OMA" id="LWIAAEH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="30505" checksum="1ADF9510E428857A" modified="2006-07-11" version="1">MARERLVSALAAEPPRLDLAALAIATLDKPLLDAPGCLHMLDVLACRVQVEAERLSEKGEVLAPLRALRHVLADIEGFRGNEDDYHSPENSFLDQVLERKLGLPITLSVVYLEVARRAGISLYGVPFPGHFLVAHDAGDHKLVMDPFHQGDILTEHGCEELLKRVAPQLKFDRNMLAPAPVELITYRMLSNLRRVYLGREDCERGLAVVDLLLLLAPDHPGELRTRAALLSNLGAYRAALKDVERCLELSPDAPDRDRLEMTARELRERAALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB38</accession>
    <name>Q1DB38_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551991.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1890"/>
    <dbReference type="EnsemblBacteria" id="ABF92106">
        <property type="protein sequence ID" value="ABF92106"/>
        <property type="gene ID" value="MXAN_1890"/>
    </dbReference>
    <dbReference type="GeneID" id="41359305"/>
    <dbReference type="KEGG" id="mxa:MXAN_1890"/>
    <dbReference type="eggNOG" id="COG5602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1593558_0_0_7"/>
    <dbReference type="OMA" id="VGQEVRY"/>
    <dbReference type="OrthoDB" id="2147300at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="19480" checksum="49CBBF0986ADE767" modified="2006-07-11" version="1">MQNDMKGIIQAAVAEAVEKTMSRQLELQERQLELLGKIAQFLGIESGSAHAASAPKRAPVPSPASKRIPAPAPTSTPKRTPSVSVRKYVRPEAAPKPTRAGPAPQKSRGRPRAAGRTATAAAPSASPSPEAPVSFAVGQEVRYKQGRGAFTAKVKAVDEKAKTVTAERVSDGKQVVRPFDKVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB48</accession>
    <name>Q1DB48_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DB48"/>
    <dbReference type="STRING" id="246197.MXAN_1879"/>
    <dbReference type="EnsemblBacteria" id="ABF86612">
        <property type="protein sequence ID" value="ABF86612"/>
        <property type="gene ID" value="MXAN_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1879"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_990122_0_0_7"/>
    <dbReference type="OMA" id="EGDSHVK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30382" checksum="42016F86A8340B5F" modified="2006-07-11" version="1">MPSAGLGRCAPVRRCWNTLHEELGVSIRTAEAQRAYRLLRRNWETLEDFEQPEALVAFLTAREGDSHVKDAVLAGLVTLAQMRAESGFFTALLWLGVWPGLDGVYRRCLRRFRVSPAEVVSAIAASFLGLVARVNLSSVQRVAAALVLGTERDVLKALSKERGAELHGVLAETGSGEPQLDLPTPSVSLVLSFESEMAELRAWLRPLVGDDTELLVSVLLYEEGYVEVGASLGLAPAAVRKRVQRALGRLRKMKKKMPGKFRCPKSLRESAFSSGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB51</accession>
    <name>Q1DB51_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551978.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1876"/>
    <dbReference type="EnsemblBacteria" id="ABF89162">
        <property type="protein sequence ID" value="ABF89162"/>
        <property type="gene ID" value="MXAN_1876"/>
    </dbReference>
    <dbReference type="GeneID" id="41359291"/>
    <dbReference type="KEGG" id="mxa:MXAN_1876"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_7_3_7"/>
    <dbReference type="OMA" id="IDTVQWA"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23918" checksum="997E1735BB1AFEEE" modified="2006-07-11" version="1">MLLAHPASDTTPVSALRPPLFPGIPPHLRTLCFVDLETTGLDASRHEVLEVAVLRVDARSLKVLAEYEARVKPTRLADAHPEALAVCGYSDEEWRDALPLQEVLATVTPLLAGTLVAGHNTSFDWGFLVESYRRSELALPSVDYHRLDTASLAWPLLATGEVESLSLNALAKRFGLHRPTPHRAMADARCALEVARCLAVRMARGGHMERLMEESGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ8</accession>
    <name>Q1DBQ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551774.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1663"/>
    <dbReference type="EnsemblBacteria" id="ABF90403">
        <property type="protein sequence ID" value="ABF90403"/>
        <property type="gene ID" value="MXAN_1663"/>
    </dbReference>
    <dbReference type="GeneID" id="41359103"/>
    <dbReference type="KEGG" id="mxa:MXAN_1663"/>
    <dbReference type="HOGENOM" id="CLU_2207180_0_0_7"/>
    <dbReference type="OrthoDB" id="1948200at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188381" evidence="1">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13674" checksum="6407A1706055D930" modified="2006-07-11" version="1">MKVNSRGYLASLAVMTLSSVACGDVDPEEAVTISQGVYGMTSYVNDVCSSGCEREPRSMTLLVKSLPQDMDVVSVTSNKDGFYEASLVLGDYRICTTFGRCTDFSVGINEVVRLDYEMSVGPGWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC56</accession>
    <name>Q1DC56_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551626.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1515"/>
    <dbReference type="EnsemblBacteria" id="ABF87975">
        <property type="protein sequence ID" value="ABF87975"/>
        <property type="gene ID" value="MXAN_1515"/>
    </dbReference>
    <dbReference type="GeneID" id="41358961"/>
    <dbReference type="KEGG" id="mxa:MXAN_1515"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1633609_0_0_7"/>
    <dbReference type="OMA" id="QLSMSFE"/>
    <dbReference type="OrthoDB" id="1540228at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="161" mass="17025" checksum="56F328B86C4A1064" modified="2006-07-11" version="1">MSDSTSGAPPRPSQADLDRYAEQFSQSLTLRLFGAQLSFPEGRKVVVTIPELRPEHRGGAGSASAVNGGILAALFDYAVGCTGALVDPGRRCATVQLSMSFERAVTGDSLRVESEIDSQTVSLLFATAWVYDGEGRVCGRCQGVVKLSNLRWASGDSPAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB4</accession>
    <name>Q1DCB4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551568.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1452"/>
    <dbReference type="EnsemblBacteria" id="ABF91237">
        <property type="protein sequence ID" value="ABF91237"/>
        <property type="gene ID" value="MXAN_1452"/>
    </dbReference>
    <dbReference type="GeneID" id="41358898"/>
    <dbReference type="KEGG" id="mxa:MXAN_1452"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_7"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="219"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="514" mass="56969" checksum="719B0AA364D2B685" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI1</accession>
    <name>GLMU_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name type="ordered locus">MXAN_1385</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="1"/>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551502.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCI1"/>
    <dbReference type="SMR" id="Q1DCI1"/>
    <dbReference type="STRING" id="246197.MXAN_1385"/>
    <dbReference type="EnsemblBacteria" id="ABF89222">
        <property type="protein sequence ID" value="ABF89222"/>
        <property type="gene ID" value="MXAN_1385"/>
    </dbReference>
    <dbReference type="GeneID" id="41358832"/>
    <dbReference type="KEGG" id="mxa:MXAN_1385"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_7"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
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            <begin position="1"/>
            <end position="466"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
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            <begin position="233"/>
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        </location>
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            <begin position="254"/>
            <end position="466"/>
        </location>
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        </location>
    </feature>
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        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
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        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
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        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57705"/>
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            <position position="336"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
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        <location>
            <position position="354"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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            <position position="369"/>
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        <ligand>
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        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        </ligand>
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        </location>
        <ligand>
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        <location>
            <begin position="389"/>
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            <position position="426"/>
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            <position position="443"/>
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        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <sequence length="466" mass="49029" checksum="09DEE4C65A60B3B3" modified="2006-07-11" version="1">MSVLAAVVLCAGKGTRMKSEKAKVLHPILGRPLCAYPLKRALELGATSVVPVVGHQAEAVEKAVRGLFPDAPLRFALQREQRGTADAVRSAEEALKGYSGRVLILYGDVPLLRRETLEALLAAHDQAGGKLAMVTTTLEDPTGYGRVIRDGGKVTRIVEHKDCTPEQRAVRECNAGIYSVDADFLWKALAEIKPQNAQGEYYLTDLVEMAAKRGPVGSVEADATETAGVNDRVELAARARVLQQRINEAHMRAGVSLQDPATAYIEEGVTVGPDTEIGPSVTLAAGTVVGKGCTIGQGSVLHASTVADGTVIKPYSVLEEARVGERNVIGPFSRLRPGTELAEDVHLGNFVETKKARIGKGSKANHLTYLGDAVIGSGCNVGAGTITCNYDGVNKHLTELGDGVFIGSDTQLVAPVKVGDGSYVGAGTTVTKNVPPGSLAVSRTPQVTKEGWVATKKARQAKARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM2</accession>
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        <submittedName>
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        <name evidence="2" type="ORF">MXAN_1344</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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            <dbReference type="EMBL" id="ABF92340.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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    </evidence>
    <sequence length="214" mass="23206" checksum="98B475AE34E94956" modified="2006-07-11" version="1">MKRPSPWLAMMFAGFMSMHATGCFGQFQLTQKIWNFNKNISGNKFVQWLMFLVLTIIPVYGLGAFIDAIVINSIEFWTGSNPVASIDGAPETTRIVKLSPTDTLRLSRDVETGVMRMELAREGQETMVRYFEPLEDGMVVRDDAGAMLIQAQEATDGAVAVTDAAGTTLTVHARDALAVARRVYEEGGAQALAQHAVAQASVSQGLASNTCVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
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        <name evidence="3" type="ORF">MXAN_1337</name>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="797"/>
        </location>
    </feature>
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        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="797" mass="86410" checksum="774010776ACC8F35" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCR2</accession>
    <name>Q1DCR2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_1304</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1304"/>
    <dbReference type="EnsemblBacteria" id="ABF87960">
        <property type="protein sequence ID" value="ABF87960"/>
        <property type="gene ID" value="MXAN_1304"/>
    </dbReference>
    <dbReference type="GeneID" id="41358751"/>
    <dbReference type="KEGG" id="mxa:MXAN_1304"/>
    <dbReference type="HOGENOM" id="CLU_112468_0_0_7"/>
    <dbReference type="OrthoDB" id="2063383at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045506">
        <property type="entry name" value="DUF6484"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20093">
        <property type="entry name" value="DUF6484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6484" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19218" checksum="FC20DE5ACD63EB29" modified="2006-07-11" version="1">MASHEHDAGRPPSQVEEPILGNLIGRVVGRGRMGTVQVDFEGNHHGPLEARLAVAVDEATLLRAIEARQEAVLCFERGTPTCPIVLGLLQPRSETPLLDAMLEAPDVEHQDGEVAIVANGQRVPIEGLLDGATEELELRCGRSSLVLRRNGQILLRGEHVLVDAGQVLRLRGGKTQIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCS0</accession>
    <name>GLGA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen synthase</fullName>
            <ecNumber evidence="1">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgA</name>
        <name type="ordered locus">MXAN_1296</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551413.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCS0"/>
    <dbReference type="SMR" id="Q1DCS0"/>
    <dbReference type="STRING" id="246197.MXAN_1296"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89473">
        <property type="protein sequence ID" value="ABF89473"/>
        <property type="gene ID" value="MXAN_1296"/>
    </dbReference>
    <dbReference type="GeneID" id="41358742"/>
    <dbReference type="KEGG" id="mxa:MXAN_1296"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_7"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000014369" description="Glycogen synthase">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <sequence length="477" mass="52120" checksum="FB84969457BA7F30" modified="2006-07-11" version="1">MNVLFISSEVAPFSKTGGLGDVAGALPAALASLGHDVKVITPRYRDLRGAERLEPTGQSLLLRFPFGELSGPILSARVSERLEVLFLENAFLFGNRHGLYGDAGGAFADNHRRFAYLSVGALQAAQRLRFIPDIIHANDWQTGLVPVALRRGFQTGPLAHAKSVFTIHNLAYQGQFPKDVMGDLALPWDLFTAHDGLEFHDTVNFLKAGLVFSDALTTVSPTYAREIQTPEQGYGLDGLLRHRAHRLHGILNGVDTHEWNPEDDAFLPARYGLKDLSGKAVCKRELLARFGLEDGPAPVFGFVSRLAWQKGMDLLLEALPAALHADIRVVGVGSGEGPLEEGLLALQSRYPKQVGVHIGFDPGLSHLVEAGADFFLMPSRYEPCGLNQMYSLRYGTVPIVRATGGLVDTVEGGLDGNGILFEAFHKSALLAAIRRALALYADPSRLDEFRRRGMEKDFSWGASGRRYEALFHDLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCV2</accession>
    <name>Q1DCV2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="9">PEP carboxykinase</shortName>
            <shortName evidence="9">PEPCK</shortName>
            <ecNumber evidence="9">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="9">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">pckG</name>
        <name evidence="13" type="ORF">MXAN_1264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551381.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1264"/>
    <dbReference type="EnsemblBacteria" id="ABF86819">
        <property type="protein sequence ID" value="ABF86819"/>
        <property type="gene ID" value="MXAN_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="41358710"/>
    <dbReference type="KEGG" id="mxa:MXAN_1264"/>
    <dbReference type="eggNOG" id="COG1274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_7"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="OrthoDB" id="267285at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="12">
        <location>
            <begin position="23"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="11">
        <location>
            <begin position="235"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="378"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="262"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="504"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF86819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="597" mass="66104" checksum="564DED47F591B0E8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW2</accession>
    <name>Q1DCW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551371.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1254"/>
    <dbReference type="EnsemblBacteria" id="ABF90534">
        <property type="protein sequence ID" value="ABF90534"/>
        <property type="gene ID" value="MXAN_1254"/>
    </dbReference>
    <dbReference type="GeneID" id="41358699"/>
    <dbReference type="KEGG" id="mxa:MXAN_1254"/>
    <dbReference type="HOGENOM" id="CLU_091669_0_0_7"/>
    <dbReference type="OMA" id="EADACEF"/>
    <dbReference type="OrthoDB" id="812517at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="21021" checksum="46680415E36F3AD5" modified="2006-07-11" version="1">MAHRYFALSEDVQPGHWYLGEPRRAVTHEEADACEFTAGRPISIQGRMKVPVTATGRPLDFSTAGISATPIVHVKVATRLSELAPDDVQFIPVDVEGQPDQYLILVATKLIRCIDPNASREVRYWKPEHGQPERVGEYRSVAGLRIDPGLVGSAKLFRTWGWDIALIVSEDLKVAIEQEQTTGARFTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD91</accession>
    <name>Q1DD91_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551242.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87061">
        <property type="protein sequence ID" value="ABF87061"/>
        <property type="gene ID" value="MXAN_1121"/>
    </dbReference>
    <dbReference type="GeneID" id="41358573"/>
    <dbReference type="KEGG" id="mxa:MXAN_1121"/>
    <dbReference type="HOGENOM" id="CLU_1853056_0_0_7"/>
    <dbReference type="OrthoDB" id="1609710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="17097" checksum="7B8B621530750CCE" modified="2006-07-11" version="1">MSLMPVDGPRSGEGAVMEMNVSRPVLAGGFWKKKRTQPVKRAKDASLVRWESQPWRRQLRDAAEYEHPVARAALVQALLAEGLTMDADAARFAGTSEDRDCISIAQVLRFADSLVLRMALACTDDHVLQLVHLRRDAEDLAERMIEWANAGRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDD0</accession>
    <name>NUOK_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoK</name>
        <name type="ordered locus">MXAN_1083</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551203.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DDD0"/>
    <dbReference type="SMR" id="Q1DDD0"/>
    <dbReference type="STRING" id="246197.MXAN_1083"/>
    <dbReference type="EnsemblBacteria" id="ABF92070">
        <property type="protein sequence ID" value="ABF92070"/>
        <property type="gene ID" value="MXAN_1083"/>
    </dbReference>
    <dbReference type="GeneID" id="41358534"/>
    <dbReference type="KEGG" id="mxa:MXAN_1083"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_0_0_7"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="OrthoDB" id="2081663at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000390138" description="NADH-quinone oxidoreductase subunit K">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <sequence length="100" mass="10865" checksum="31F4CB8D853B2142" modified="2006-07-11" version="1">MVPITYYLLLAAALFCMGMFGVLVRRNALVVFMSVELMLNAANLTFVAFARMRGDNLGHVSAFFVIAVAAAEAAIGLAIVIAVFRSRGSILLEDLRTMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDH3</accession>
    <name>Q1DDH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glkA</name>
        <name evidence="1" type="ORF">MXAN_1039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551160.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1039"/>
    <dbReference type="EnsemblBacteria" id="ABF87890">
        <property type="protein sequence ID" value="ABF87890"/>
        <property type="gene ID" value="MXAN_1039"/>
    </dbReference>
    <dbReference type="GeneID" id="41358493"/>
    <dbReference type="KEGG" id="mxa:MXAN_1039"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_7"/>
    <dbReference type="OMA" id="FEPEVIC"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="35177" checksum="36345DE87AAB6B74" modified="2006-07-11" version="1">MREANAVGSRGKAAERDTLECWGGVDLGGTKIEAVVVDRAGTVLGKMRQPTPADGEPGDVVRAIHDALEGAAHAAGLTSRQLLGVGVGAPGAVNANEGTLGHVSNVGRGWSTPYPVAGDLGARVGRPVVLGNDVQVAVAAEYRLGAGRAFRSLLGVWWGTGVGGGLVLDGVPWRGRGAAGEVGHMVVKPGGARCGCGRRGCLEAYAGRASMERRAHKAVRQGETTILFDLMRKKGRTRLTSSIWARALAQEDALATWLFGRAVRMLGAGLASAINLLDVEAVVLGGGLGTRLGPEFAGRIHEAMRPHIFVPERQPPVRVAELGELSGAIGAALLAQPPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW1</accession>
    <name>Q1DDW1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551022.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0901"/>
    <dbReference type="EnsemblBacteria" id="ABF89613">
        <property type="protein sequence ID" value="ABF89613"/>
        <property type="gene ID" value="MXAN_0901"/>
    </dbReference>
    <dbReference type="GeneID" id="41358360"/>
    <dbReference type="KEGG" id="mxa:MXAN_0901"/>
    <dbReference type="eggNOG" id="ENOG502ZX80">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2071712_0_0_7"/>
    <dbReference type="OMA" id="WAYLIHL"/>
    <dbReference type="OrthoDB" id="1698280at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="12663" checksum="5D380DA143B9AC62" modified="2006-07-11" version="1">MMETKWAYLIHLLGWTLPVIAFQLVVLVRHYKERSGAVLKAVLPPAFIMGLYLSIADHLAISTGIWNFGEGKHLGVYLGVVPLEEVVFFLITSVLVSLGLALFTGLVALLGEARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE23</accession>
    <name>Q1DE23_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550960.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0838"/>
    <dbReference type="EnsemblBacteria" id="ABF87317">
        <property type="protein sequence ID" value="ABF87317"/>
        <property type="gene ID" value="MXAN_0838"/>
    </dbReference>
    <dbReference type="GeneID" id="41358299"/>
    <dbReference type="KEGG" id="mxa:MXAN_0838"/>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_720944_0_0_7"/>
    <dbReference type="OMA" id="HALASWT"/>
    <dbReference type="OrthoDB" id="1861148at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="196"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="44517" checksum="6EDA5E4656546C25" modified="2006-07-11" version="1">MTAQAGITTKVVPRIQDVPQALWDDKVARGHPFKSAAFLSCLEDSFPERKFGYLIVSQGADVVGLAVITEERLDLSLLLPEQVGTLTKGVRKVLPGFLSLGLGMVGTFETAERHWWYDAQRVSEHDFARALLAACDEVCGDAALLLVRDFMEALPEDVRLESWFLQRGFKQVANHPMAMVALDGLSSEAHFQRLKKKSRQNLRKKLKDAEALGFQVERVRDFRPLIDECYPLYLQVHEGASEFKRNPFPRAFFETIAERMPTTSSFLTLRDSAGHLIAFILTGTGGGINNPFCIGMDYARTEGTPAYYLMMWKEIEHAARTGCRVVDLGLTSYFVKQTVGAELEGMTMAARIQSAWLRPLLNPLLPALLSEKQPQERRKFRVSTFDDDSQPPTDQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL5</accession>
    <name>Q1DEL5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550771.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0640"/>
    <dbReference type="EnsemblBacteria" id="ABF90521">
        <property type="protein sequence ID" value="ABF90521"/>
        <property type="gene ID" value="MXAN_0640"/>
    </dbReference>
    <dbReference type="GeneID" id="41358118"/>
    <dbReference type="KEGG" id="mxa:MXAN_0640"/>
    <dbReference type="eggNOG" id="COG3803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065010_2_0_7"/>
    <dbReference type="OMA" id="YMPYMHS"/>
    <dbReference type="OrthoDB" id="1603769at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="21525" checksum="109F843C797FE0D1" modified="2006-07-11" version="1">MASAEEILSFWFGQPRERWFLRDEAFDDECRRRFLPAVERAAEGELDDWRDEPRSCVALLLLLDQFPRNLFRGTPQAFASDARAREVARHGLARGLDMALPPLWRWFMYLPFEHSESVNDQRLSVALFEVLALYHSDSRAALDYARQHRDVIQRFGRFPHRNVTLGRPTTPEETVFLQEPGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF75</accession>
    <name>Q1DF75_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88279">
        <property type="protein sequence ID" value="ABF88279"/>
        <property type="gene ID" value="MXAN_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0428"/>
    <dbReference type="HOGENOM" id="CLU_2974662_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="58" mass="6742" checksum="0927BCF4E782E751" modified="2006-07-11" version="1">MHVMPESEDGLHQHKFFRTYDSMRDVAGVLIFEAQCLPFEAALHELLYAPCLKEEIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK6</accession>
    <name>Q1DFK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88571">
        <property type="protein sequence ID" value="ABF88571"/>
        <property type="gene ID" value="MXAN_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0287"/>
    <dbReference type="eggNOG" id="ENOG5031NJK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3027534_0_0_7"/>
    <dbReference type="OMA" id="YMDDEGL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="53" mass="5808" checksum="BA6CCC006B6F97F2" modified="2006-07-11" version="1">MVHDDTTYMDDEGLPYVDPRQDGGAESSEADEGAPGRRWGYSEESWGGWAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL5</accession>
    <name>Q1DFL5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0277</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550422.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0277"/>
    <dbReference type="EnsemblBacteria" id="ABF87275">
        <property type="protein sequence ID" value="ABF87275"/>
        <property type="gene ID" value="MXAN_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="41357777"/>
    <dbReference type="KEGG" id="mxa:MXAN_0277"/>
    <dbReference type="eggNOG" id="ENOG5033FUY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651846_0_0_7"/>
    <dbReference type="OMA" id="TRWWLSG"/>
    <dbReference type="OrthoDB" id="1236596at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="47182" checksum="4C2D3A72D66B8E38" modified="2006-07-11" version="1">MGVEWCRCPPHPTLPMTAVAPGPSGSESPPPAAGEGTSIGVSARWARWAWWLVLAVLAVAAIAVGQHPRRGVDFRVYLMAAERFWEATDIYRLSDGHMPFKYAPITAPLFLPFTLLPARAAVALWNLGSIAALAAVARLTMRATPSSGEATPWAWAPALTTLALLPAFTFELFYGQVDAVILLLILLCTLGAERGQVWRPGAAFAVAFLLKPPAALVGLFFLWRRHWRVIGATAVVGGILTLPTLARYGWDGTLVQFQLWSDTLARTTPPWALQSNTQGLPTVLLALVYPPDTVVPPGDMSLAQAVAMVLFVAAVVWARPGPADLIAVCCLGVTLLSPLAWRANYVLAWPLIRAAVESRHRPNLVLVALIALTGLLVSDSGLGAEWSRHVLLWRPFALVYTGLLIVLLSQMRRMGAPRAVADADAVSRLPRCFGGGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFP3</accession>
    <name>Q1DFP3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0249"/>
    <dbReference type="EnsemblBacteria" id="ABF90281">
        <property type="protein sequence ID" value="ABF90281"/>
        <property type="gene ID" value="MXAN_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0249"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_7"/>
    <dbReference type="OMA" id="DPGIFWN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="26467" checksum="D90625C32B09535D" modified="2006-07-11" version="1">MDRAKERLESLGALSRMTGQVFSRAVRPPFDWRGLVYHTESLGVRSLPIALLTAMFAGLVISLQFGYFLSRFGVQYTVGRVVILTLFRELAPVLTALTVGARIGSGIAAELGAMTVTEQVDAIRALGADPLRKLVVPRVLACLIVLPVLTVFADVVGLVAGALVVNIQYAITLNLFFQGALDAVLMPDFASGVFKGAVFGLIIGLVGCFRGLTVEGGTEGVGRATTQTVATTSVSVCLADFFITQLTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFR6</accession>
    <name>Q1DFR6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550371.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0225"/>
    <dbReference type="EnsemblBacteria" id="ABF92283">
        <property type="protein sequence ID" value="ABF92283"/>
        <property type="gene ID" value="MXAN_0225"/>
    </dbReference>
    <dbReference type="GeneID" id="41357726"/>
    <dbReference type="KEGG" id="mxa:MXAN_0225"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_7"/>
    <dbReference type="OMA" id="AVWSGDT"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="417"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="505" mass="54434" checksum="21DA41C96A44683A" modified="2006-07-11" version="1">MPIVHDWLARRAALAPERTALIDADHGERRISFREWNDSASRTAAFLHHALGVGRGDRVAVLAYNCVEFLDLFFACAKLGAVLQPLNWRLSATELGGLLADAEPSVFVFGPEFRTQVEAVRSGASFVRHWLSLAAPGPSERAFSERDTQTDVALPPLELEEDAPWVLCYTGGSTGLPKAAVLTHRSITANAVNTVMGWGLTADDVAILNAPLFHAGGLSVFTAPLAYAGGASVVCRSFDVEGVFDLVRRGVVSLFFGVPTMFIEMQRHPRFDAVDLSRLKLVISGGAPCPAPVFERFFARGVDFKTGYGLTEAGPNNFWLPPEDVRRKPGAVGVPLFHVEARIDGETQPGDVGELLLRGPHLCAGYWRRPGDTARTFADGWLHTGDLATRDAEGCFRIVGRSKDLIISGGENIYPSEVESVLAGHPDVAEVAVIGVADPKWGETPRALVVARPGTSPSAEALLRFCDGRLARYKTPKSIRFVDALPRTSAGKVDRRTLGAAHGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX8</accession>
    <name>Q1DFX8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550309.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0162"/>
    <dbReference type="TCDB" id="1.B.66.1.5">
        <property type="family name" value="the putative beta-barrel porin-2 (bbp2) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89475">
        <property type="protein sequence ID" value="ABF89475"/>
        <property type="gene ID" value="MXAN_0162"/>
    </dbReference>
    <dbReference type="GeneID" id="41357665"/>
    <dbReference type="KEGG" id="mxa:MXAN_0162"/>
    <dbReference type="eggNOG" id="ENOG502Z88H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043652_0_0_7"/>
    <dbReference type="OMA" id="PSHIGFE"/>
    <dbReference type="OrthoDB" id="384212at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011486">
        <property type="entry name" value="BBP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07642">
        <property type="entry name" value="BBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="367" mass="38801" checksum="AD8C0C11ECEC4BE1" modified="2006-07-11" version="1">MLASPLPSLVSSLLLSQAPSPEPSPDAEAPGLLSRLEVEGGVDVYFGYNTNRPADGASFIPGTGTTARRDNEVSINLASLGVSLAPEPVGFKVLLGFGTGIEVLHQAEPEGPAIGPEVWRHLQQATVSYATGPLTLEAGVYPSHIGLESFQSRLNWNYTRSWMGELSPYYQSGLKSTWAFDDAWSAQLHLLNGWQTIGENNRGKALGTQVAYAGPRLSTALNTFVGEEGDGGLRLFVDAVATWKVTHAFALAATADVGRQARSGQSAALWYAAGFNARVQLSDVVAVAARVEAYRDEDGLITGAVQTLAGGTLTLELKPAEHLVLKMEARRDTSTADVFTGRATGGDGAPMLEDAETLGVLSAVAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG30</accession>
    <name>Q1DG30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cls</name>
        <name evidence="2" type="ORF">MXAN_0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550257.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0110"/>
    <dbReference type="EnsemblBacteria" id="ABF86832">
        <property type="protein sequence ID" value="ABF86832"/>
        <property type="gene ID" value="MXAN_0110"/>
    </dbReference>
    <dbReference type="GeneID" id="41357615"/>
    <dbReference type="KEGG" id="mxa:MXAN_0110"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_0_1_7"/>
    <dbReference type="OMA" id="YIRQAVN"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="415" mass="45951" checksum="1C97110F5747C351" modified="2006-07-11" version="1">MKLAWLVPVVLIAAGCPAPNHRHDLRLRALPGTSPEARSLAFFQSLGVALVPGHRVELVENGFIFDAIEEEILAARTSIHIISYIWRPGEPSDRLVRALAARRPGVACRVLVDPLGSVNFEAVIPALAASGCDARYFRPIQGDFVALDAVRLRARNHRKMVVRDGEVGITGGWGIWKSWMGNAQSAESWRDMNIRVEGPAVREMQVAFAQNWQEAGGDFLPATDFPEPRYAGDARAGFVASTDNRFLSDARRMTLLTIAAAQERLWIANSYFIPSDAISDMLLEKVKQGVDVRVLVPGRHHDVGPVNAAQRASYARLLEGGVRIWEYELSMMHSKTMLVDDSLSVVGSTNMDPLALTTLEECSVVVEDVALAAQLAASFEKDLRHSREIHWSGWKRRGLLQKLGERLPWFIGSFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>P95334</accession>
    <accession>Q1CXT5</accession>
    <name>DNAK_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dnaK</name>
        <name type="synonym">sglK</name>
        <name type="ordered locus">MXAN_6671</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5357" last="5368">
            <title>A chaperone in the HSP70 family controls production of extracellular fibrils in Myxococcus xanthus.</title>
            <authorList>
                <person name="Weimer R.M."/>
                <person name="Creighton C.X."/>
                <person name="Stassinopoulos A."/>
                <person name="Youderian P."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="9765567"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Potential chaperone for other proteins involved in social motility.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="U83800">
        <property type="protein sequence ID" value="AAC64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556596.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P95334"/>
    <dbReference type="SMR" id="P95334"/>
    <dbReference type="STRING" id="246197.MXAN_6671"/>
    <dbReference type="PRIDE" id="P95334"/>
    <dbReference type="EnsemblBacteria" id="ABF90084">
        <property type="protein sequence ID" value="ABF90084"/>
        <property type="gene ID" value="MXAN_6671"/>
    </dbReference>
    <dbReference type="GeneID" id="41363869"/>
    <dbReference type="KEGG" id="mxa:MXAN_6671"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_7"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000078501" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC64205." evidence="2" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="607" mass="65348" checksum="4296F6E804083717" modified="2006-09-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU7</accession>
    <name>Q1CVU7_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7369"/>
    <dbReference type="EnsemblBacteria" id="ABF89871">
        <property type="protein sequence ID" value="ABF89871"/>
        <property type="gene ID" value="MXAN_7369"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7369"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_0_7"/>
    <dbReference type="OMA" id="MREPVDH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="16914" checksum="5F8529B6DFB84CA6" modified="2006-07-11" version="1">MQPSAVMREPVDHKLAAVLGGAARDARLRLGLTQGDVAERMGMAMEVYSRLERGKMLPRTQTLRRLCDVLQVSADTLLGVGRPDGAPVMPRKTVKEDPVELRRMTRKLRELEPGQLRAVSRVVNAVVTVLPQPAAPAPAAPAKPAARAARKRRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI5</accession>
    <name>Q1CWI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7125"/>
    <dbReference type="EnsemblBacteria" id="ABF92979">
        <property type="protein sequence ID" value="ABF92979"/>
        <property type="gene ID" value="MXAN_7125"/>
    </dbReference>
    <dbReference type="GeneID" id="41364299"/>
    <dbReference type="KEGG" id="mxa:MXAN_7125"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016249_3_1_7"/>
    <dbReference type="OMA" id="QILCGNV"/>
    <dbReference type="OrthoDB" id="566369at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="555" mass="60436" checksum="8483AB6943F10A30" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXE5</accession>
    <name>Q1CXE5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, S9A (Prolyl oligopeptidase) subfamily</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556736.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6811"/>
    <dbReference type="EnsemblBacteria" id="ABF89319">
        <property type="protein sequence ID" value="ABF89319"/>
        <property type="gene ID" value="MXAN_6811"/>
    </dbReference>
    <dbReference type="GeneID" id="41364000"/>
    <dbReference type="KEGG" id="mxa:MXAN_6811"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_4_0_7"/>
    <dbReference type="OMA" id="HKAYEDF"/>
    <dbReference type="OrthoDB" id="315644at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187965" evidence="1">
        <location>
            <begin position="22"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9_N" evidence="3">
        <location>
            <begin position="26"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="491"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="695" mass="77104" checksum="53E410CB5618E4AA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ5</accession>
    <name>Q1CXJ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556686.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6761"/>
    <dbReference type="EnsemblBacteria" id="ABF89901">
        <property type="protein sequence ID" value="ABF89901"/>
        <property type="gene ID" value="MXAN_6761"/>
    </dbReference>
    <dbReference type="GeneID" id="41363951"/>
    <dbReference type="KEGG" id="mxa:MXAN_6761"/>
    <dbReference type="HOGENOM" id="CLU_1729417_0_0_7"/>
    <dbReference type="OMA" id="FHRIGFE"/>
    <dbReference type="OrthoDB" id="1684545at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18019" checksum="84FE909A868DF053" modified="2006-07-11" version="1">MAWNESDWNAPLRRRPAPLILVVVLAVTAGHLLVTQCSGRSPATQAAPPSDAEARVNVLALCDAVQTYRDEHGVYVTAGPTPKEVPRGGRAVAFPKDEAFHRIGFEPDGKVHFQYQVVVQESPVGEPEVSCIARGDFDGDGLNSLYRVRLDANGMTTPIEVEREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW2</accession>
    <name>Q1CXW2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">modB</name>
        <name evidence="11" type="ORF">MXAN_6644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556569.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6644"/>
    <dbReference type="EnsemblBacteria" id="ABF88174">
        <property type="protein sequence ID" value="ABF88174"/>
        <property type="gene ID" value="MXAN_6644"/>
    </dbReference>
    <dbReference type="GeneID" id="41363840"/>
    <dbReference type="KEGG" id="mxa:MXAN_6644"/>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_3_7"/>
    <dbReference type="OMA" id="MYSFIET"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF88174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="23717" checksum="7DED97193F136F9F" modified="2006-07-11" version="1">MEGVAALVSFTIWVATLATLLILPPGLAVAYALARWEGPGKGVVETVLTLPLVLPPTAVGLVLLELLGRNGPLGRVLDAWGMEVVFTPKAVVLASAVMAFPLLVRSARSGFEEVDPRLVAVARTLGDSRTRAFFRVTLPLAWRGVLVGTLLAFSRALGEFGATVLVAGNIPGRTQTLSLAIFQRTQLGRDAEALRLAGVAALLAFVAVFATEAVTRRRGRRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM3</accession>
    <name>Q1CYM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6376"/>
    <dbReference type="EnsemblBacteria" id="ABF88740">
        <property type="protein sequence ID" value="ABF88740"/>
        <property type="gene ID" value="MXAN_6376"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6376"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357083_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="785" mass="88093" checksum="73D83C6EC0E392AB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV9</accession>
    <name>Q1CYV9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6288"/>
    <dbReference type="EnsemblBacteria" id="ABF92356">
        <property type="protein sequence ID" value="ABF92356"/>
        <property type="gene ID" value="MXAN_6288"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6288"/>
    <dbReference type="HOGENOM" id="CLU_3009559_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="56" mass="6320" checksum="6607BCEFC6F1EF3B" modified="2006-07-11" version="1">MWINQDGAVRGQVELGFVDFAKATPTVQALPRLRIARTEKPRGRERAGHPAHLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYY5</accession>
    <name>Q1CYY5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adventurous gliding motility protein AgmJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">agmJ</name>
        <name evidence="1" type="ORF">MXAN_6259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556201.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6259"/>
    <dbReference type="EnsemblBacteria" id="ABF89988">
        <property type="protein sequence ID" value="ABF89988"/>
        <property type="gene ID" value="MXAN_6259"/>
    </dbReference>
    <dbReference type="GeneID" id="41363482"/>
    <dbReference type="KEGG" id="mxa:MXAN_6259"/>
    <dbReference type="eggNOG" id="ENOG5030TNM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428154_0_0_7"/>
    <dbReference type="OMA" id="FRMHVAS"/>
    <dbReference type="OrthoDB" id="441011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="636" mass="71357" checksum="4763067C62BFB97E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYZ9</accession>
    <name>Q1CYZ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch motif/HYR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6245"/>
    <dbReference type="EnsemblBacteria" id="ABF90562">
        <property type="protein sequence ID" value="ABF90562"/>
        <property type="gene ID" value="MXAN_6245"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6245"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002226_0_0_7"/>
    <dbReference type="OMA" id="GTAENQG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="1217"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1339" mass="137609" checksum="2A4F136ED1DA1AC8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ81</accession>
    <name>Q1CZ81_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556105.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6161"/>
    <dbReference type="EnsemblBacteria" id="ABF87907">
        <property type="protein sequence ID" value="ABF87907"/>
        <property type="gene ID" value="MXAN_6161"/>
    </dbReference>
    <dbReference type="GeneID" id="41363391"/>
    <dbReference type="KEGG" id="mxa:MXAN_6161"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_3_1_7"/>
    <dbReference type="OMA" id="FHVVRKR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="27644" checksum="FC72818DA287F083" modified="2006-07-11" version="1">MGATRESNPLYAKVELTLASEIAAGVLPPRSQLPTEDRLIERFGVSRTTVRKAIENLVARGLVEIRRGVGTFVAQPKIIQELTELTGFVEDMQALGRTPTARLLDSQIVPADADVARQLAVSPGSLVMRIQRVRLADGLAMSFDETYLPRELGEKIVTHDLETEPIFALLEERYHLPLIEAEYRLEAITATPTVAQALAVEPGNPVFLIERTSYTEGSRPIDYERLHYRGDLIRFITRLSRRPRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ87</accession>
    <name>Q1CZ87_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkylphosphonate utilization operon protein PhnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556099.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6155"/>
    <dbReference type="EnsemblBacteria" id="ABF85895">
        <property type="protein sequence ID" value="ABF85895"/>
        <property type="gene ID" value="MXAN_6155"/>
    </dbReference>
    <dbReference type="GeneID" id="41363384"/>
    <dbReference type="KEGG" id="mxa:MXAN_6155"/>
    <dbReference type="eggNOG" id="COG2824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134486_0_1_7"/>
    <dbReference type="OMA" id="SCLYEWN"/>
    <dbReference type="OrthoDB" id="1507972at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="12096" checksum="4F4FDCCC4CA3ECF4" modified="2006-07-11" version="1">MSALPSCPKCNSAYTYEDGSLYVCPECAHEWSTVAAAAPGEEKREVRDAYGNLLQDGDSVTVIKDLKVKGSSTVVKVGTKVRSIRLVDGDHDIDCKIDGIGAMGLKSEFVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC2</accession>
    <name>Q1CZC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556065.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6116"/>
    <dbReference type="EnsemblBacteria" id="ABF91357">
        <property type="protein sequence ID" value="ABF91357"/>
        <property type="gene ID" value="MXAN_6116"/>
    </dbReference>
    <dbReference type="GeneID" id="41363351"/>
    <dbReference type="KEGG" id="mxa:MXAN_6116"/>
    <dbReference type="HOGENOM" id="CLU_696032_0_0_7"/>
    <dbReference type="OMA" id="YIAWREQ"/>
    <dbReference type="OrthoDB" id="554451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188011" evidence="1">
        <location>
            <begin position="31"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="419" mass="45203" checksum="A4A10607BAAAD63A" modified="2006-07-11" version="1">MHLTPSRPIPLGLPRALLVTSVLLASTSHAQTTPLEDNNRITAGYIELAYEVGGLLDPTLSPGGTSAVRPNWFVFAPHASRTGGEGLLGASLARSVIRAARGQPSLSLQQALGRVGLTGTLHLSVQQLGLQLVLSGLPFDVAASLASLTTALNGAALLDARTLLTTTARFAALYASAPGVLPLDKAERIVDTLERTLNESNLAIFTDIGGSGRLYMDWRAGAGVVTPERVLTEFTLVGAVPTQSRQAYDYALAHAFDTPRPFEFDTLFPGMHWKSLLVAAFALYEEARMAPTPAARDALIAMGNNYIAWREQHDMAQPVFSPAVQRPDEVSRVELLRAITPLLSTDFGTMTWTYADFAYSRPDRDGNPLTSPPTEYNWALFWDRWTGILFAFDAAYLQPTALWVMPEPLVDPTAAANGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZH0</accession>
    <name>Q1CZH0_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556017.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6068"/>
    <dbReference type="EnsemblBacteria" id="ABF87892">
        <property type="protein sequence ID" value="ABF87892"/>
        <property type="gene ID" value="MXAN_6068"/>
    </dbReference>
    <dbReference type="GeneID" id="41363304"/>
    <dbReference type="KEGG" id="mxa:MXAN_6068"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495929_0_0_7"/>
    <dbReference type="OMA" id="LANGAMC"/>
    <dbReference type="OrthoDB" id="279546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="556" mass="59992" checksum="5A640DB248EDF5FB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZI2</accession>
    <name>Q1CZI2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6056"/>
    <dbReference type="ESTHER" id="myxxd-q1czi2">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86606">
        <property type="protein sequence ID" value="ABF86606"/>
        <property type="gene ID" value="MXAN_6056"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6056"/>
    <dbReference type="eggNOG" id="COG2819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039834_0_0_7"/>
    <dbReference type="OMA" id="KWEVEPR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187925" evidence="1">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="32336" checksum="6D87E099702B9DBD" modified="2006-07-11" version="1">MARRTLREQVMRTSMKCMGLLLLVLGGACASTRPAVTEPVPPHQTFTIESAKLKEPRHITVYLPPGYTTAAESRFPVLYMPDGGLKEDFPHLATTVDTAIRAGELRPLIIVGIENTVRRRDMTGPTTVASDLEVAPVTGGSATFRAFIHEELMPEVERRYRVTQERAIIGESLAGYFIVETFFLQPELFGTYLALSPSLWWNAESLVKGAGEWFAARPDLRAGLYVSSANETGDIVPAVARLQDVLRTSAPAGLKWEVEPRPDLRHDNIYRESSPSVLRKWLPPVVAAERAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D8</accession>
    <name>Q1D0D8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsE</name>
        <name evidence="9" type="ORF">MXAN_5748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555699.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5748"/>
    <dbReference type="EnsemblBacteria" id="ABF90322">
        <property type="protein sequence ID" value="ABF90322"/>
        <property type="gene ID" value="MXAN_5748"/>
    </dbReference>
    <dbReference type="GeneID" id="41362991"/>
    <dbReference type="KEGG" id="mxa:MXAN_5748"/>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="PTRGHID"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="230" mass="25456" checksum="C1C11EDE2B977D44" modified="2006-07-11" version="1">MIQFFHVYKAYPGDPPVLSDINLNVEKGEFVFLTGPSGAGKTTLLKLIFCAEKATKGQILVGGRNIARIRESAVPYLRRNIGVVFQDFKLLPHRTVEDNVSFTLDVLGVPRAEAREKVRRMLKLVGLEHKAGSFPLRLSGGEQQRVVIARALVNDPTILLADEPTGNLDPALTVEIMDLLTQVNVRGTTVMVATHDATLLSRYQKRTVRLERGQIVSDEDGVKAARRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H3</accession>
    <name>Q1D0H3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5712"/>
    <dbReference type="EnsemblBacteria" id="ABF89295">
        <property type="protein sequence ID" value="ABF89295"/>
        <property type="gene ID" value="MXAN_5712"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5712"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_7"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="236"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="52002" checksum="2E57F7729A01F72F" modified="2006-07-11" version="1">MRRGELLAVVGENGAGKSSLMNVLYGLYQPDAGVLSLDGQPVRFKSPRDAIARGIGMVHQHFMLVPTLSVAENVVLGREPTRNGLLDLERAVQDVSATCARFGFQLEPRARVDTLSVGSQQKVEIVKALHRGAQVLILDEPTAVLTPQESDELARVMRGLVAQGHTVVLISHKLKEVLGVADRIAVMRRGRCVAEVRAADTTAEQLAALMVGDGQRAPAAAAPATAASQAPGEPLLDVRGLQATGDNGRPALRGVDLEVRAGEIVGIAGVDGNGQRELAEVLTGLRPLTSGSGALLGGPLSDLTPAQARTRGVGHIPEDRLHRAVVKALSVEENVALGRHTRPPFAKGPWIDFKGRRERTRELTVAYDVRPPDPEVALRALSGGNQQKVVVARELDARPRLLVVVQPTRGLDVGAVAQVHAKLREARDQGTGVLLVSLDLEEVLALSDRVYVFFEGRVTGHFLRHEFDERELGRRMLGTTEPGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0I7</accession>
    <name>Q1D0I7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555650.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5698"/>
    <dbReference type="EnsemblBacteria" id="ABF92117">
        <property type="protein sequence ID" value="ABF92117"/>
        <property type="gene ID" value="MXAN_5698"/>
    </dbReference>
    <dbReference type="GeneID" id="41362943"/>
    <dbReference type="KEGG" id="mxa:MXAN_5698"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582363_0_0_7"/>
    <dbReference type="OMA" id="YRKMNVR"/>
    <dbReference type="OrthoDB" id="1003442at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="323"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="44277" checksum="412FDB72EC72C052" modified="2006-07-11" version="1">MRLDALSRLVRLSLARERKGAFFSAFGVAMGVGALVFFVGLGLGVGRVIREKVFPTDARLVDVVPPAVSLGSLLGGGKLDAPTVERLRELPGVEAAYRKMNVRVPAVTRYDGVFFGTRLRMGMEVLALGVEPALVQGDVQMGEFKDAGEGQPIPALVSTRLLELYNKTFAPARKLPQLSANMLVGFGFPVEFNRSYVAAASASGPTQSGQAQVVGASDRALLAGITIPLDAAIRLNRAFGVDSENYSGVTLVATDPSQVPVIVDAVKGMGLEIDDQERRMAENSGAAVALTTSALALLSLLICILAAVNIAHALSASVRARAKEIGVMQAVGASRADIRAIVLAEAAVVGLAGGAAGTIAALLLALGVNRLAAGYLPNFPFKPDSFFSFPWPVVAGGVVLGLVAALVGAYFPSRRAAATDPARTLAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0P6</accession>
    <name>ACYP_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Acylphosphatase</fullName>
            <ecNumber>3.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acylphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">acyP</name>
        <name type="ordered locus">MXAN_5638</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555592.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D0P6"/>
    <dbReference type="SMR" id="Q1D0P6"/>
    <dbReference type="STRING" id="246197.MXAN_5638"/>
    <dbReference type="EnsemblBacteria" id="ABF86153">
        <property type="protein sequence ID" value="ABF86153"/>
        <property type="gene ID" value="MXAN_5638"/>
    </dbReference>
    <dbReference type="GeneID" id="41362884"/>
    <dbReference type="KEGG" id="mxa:MXAN_5638"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_1_0_7"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000326756" description="Acylphosphatase">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
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        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="99" mass="10918" checksum="206D9469C1B86784" modified="2006-07-11" version="1">MGQSMSGTRRASLRIEGKVQGVFFRESARVEATRLGLTGWVRNRPDGAVEAVVEGEPAVLEEFIHWCHRGPAQARVSGVQRTDSKATGEFSQFNVERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T6</accession>
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        <submittedName>
            <fullName evidence="6">OmpA domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">MXAN_5598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DK1622</strain>
        </source>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="OMP_bac"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="1243"/>
        </location>
    </feature>
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        <location>
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            <end position="2690"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <end position="2070"/>
        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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            <end position="1901"/>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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    </feature>
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            <end position="2548"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF92571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2699" mass="274666" checksum="682E8D1483951544" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L5</accession>
    <name>Q1D1L5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5307"/>
    <dbReference type="EnsemblBacteria" id="ABF86788">
        <property type="protein sequence ID" value="ABF86788"/>
        <property type="gene ID" value="MXAN_5307"/>
    </dbReference>
    <dbReference type="GeneID" id="41362577"/>
    <dbReference type="KEGG" id="mxa:MXAN_5307"/>
    <dbReference type="eggNOG" id="COG4430">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2525775_0_0_7"/>
    <dbReference type="OMA" id="DAYKARP"/>
    <dbReference type="OrthoDB" id="1937469at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9779" checksum="E5901F9D3E4E2440" modified="2006-07-11" version="1">MTMAPVKRPTLKRAVNPMPANVRAALLQRGLMDAYKARPPYQQNDYLGWIARAKLEATRQKRLDQMLDELAGGTKYMNMAWSGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1P6</accession>
    <name>Q1D1P6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_5275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5275"/>
    <dbReference type="EnsemblBacteria" id="ABF91464">
        <property type="protein sequence ID" value="ABF91464"/>
        <property type="gene ID" value="MXAN_5275"/>
    </dbReference>
    <dbReference type="GeneID" id="41362552"/>
    <dbReference type="KEGG" id="mxa:MXAN_5275"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_7"/>
    <dbReference type="OMA" id="DCEAEIQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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            </authorList>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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        <location>
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            <begin position="491"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="792" mass="86408" checksum="B962BBF57BDE5F3F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E9</accession>
    <name>Q1D2E9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mvk</name>
        <name evidence="12" type="ORF">MXAN_5019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554995.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5019"/>
    <dbReference type="EnsemblBacteria" id="ABF90439">
        <property type="protein sequence ID" value="ABF90439"/>
        <property type="gene ID" value="MXAN_5019"/>
    </dbReference>
    <dbReference type="GeneID" id="41362304"/>
    <dbReference type="KEGG" id="mxa:MXAN_5019"/>
    <dbReference type="eggNOG" id="COG1577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_7"/>
    <dbReference type="OMA" id="HSAVYGF"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="220"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="31951" checksum="5067BE773FE3A45F" modified="2006-07-11" version="1">MAPRPESLSAFGAGKVILLGEHSVVYGHPALAGPLSQGVTARAVPAKACQLALPSTLSRPQRAQLTAAFARAAEVTGAPPVKVSLEADLPLAVGLGSSAALSVACARLLLQAAGKVPTPKDAARVAWAMEQEFHGTPSGVDHTTSAAEQLVLYWRKPGAAKGTGQVVESPRPLHVVVTLAGERSPTKKTVGALRERQARWPSRYERLFAEIGRVSSEGAKAVAAGDLEALGDAMNVNQGLLAALGLSSPPLEEMVYRLRELGALGAKLTGAGGDGGAVIGLFLEPKPVVTKLTRMGVRCFSSQLAGPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2J9</accession>
    <name>Q1D2J9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554946.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4968"/>
    <dbReference type="EnsemblBacteria" id="ABF92257">
        <property type="protein sequence ID" value="ABF92257"/>
        <property type="gene ID" value="MXAN_4968"/>
    </dbReference>
    <dbReference type="GeneID" id="41362253"/>
    <dbReference type="KEGG" id="mxa:MXAN_4968"/>
    <dbReference type="eggNOG" id="ENOG5032M8R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_547280_0_0_7"/>
    <dbReference type="OMA" id="PFRPLEF"/>
    <dbReference type="OrthoDB" id="314324at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="491" mass="56349" checksum="49BDF4F205191457" modified="2006-07-11" version="1">MSQDTPSSPPRVPRDFYADLMRASQTSRAGFLAERERWLRGVPVEGREELLFEFEMLLRAVERYLNLNTVVDARDRPLVTRDFREELADVRDAMDRAIRVARHLQDPDSDQKMVFRKYVETQLADDRVRRALIEEQLDQETPPESLFVLREAFDALKNLLDHLLKLPAANLGLFQDVGKLSLREIVLNRYFRPFRPLEFRVEYDRLRSVRLLDTLVTLQEEQRTAFTTAFLGLFRLLHYLAYVDAEEQPPFSRRVRVLLALVRSEATALASWMHSELSPNAGSKSLQAATLRAARDIARETERVAREVLVNLDRDAEAPLRAASAFTAVLRTQVVALVEALAPNGGLADGVFDELMSPQEAALRLRKDLWVYAQLCRAAESHLRAEDVPAAERVLDALKGFLGYFHDGSYQLLRYGDYDAFDRFTSLLVELPWPPEGPGIRARLGEDLRRFIQTLESTFHSVSRRTHLQGRGFDRQDAEALRDRFLTTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2P8</accession>
    <name>Q1D2P8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554897.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4919"/>
    <dbReference type="EnsemblBacteria" id="ABF86530">
        <property type="protein sequence ID" value="ABF86530"/>
        <property type="gene ID" value="MXAN_4919"/>
    </dbReference>
    <dbReference type="GeneID" id="41362204"/>
    <dbReference type="KEGG" id="mxa:MXAN_4919"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_7"/>
    <dbReference type="OMA" id="AGIHFCI"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="421" mass="46155" checksum="00AF7904C807E3FF" modified="2006-07-11" version="1">MSKTNAPSGLGSEYHPLDSPQLENPHPFLARARSEEPVFFSPALGAWVVTRHADISAVVADTTRFSSAESITVGAATTPPEVVTALMDGYPLVPSLVDNDPPAHGRFRSLVSKAFTGRRLAEKEPFIRTLVDALIHSFRHERQADLFLRFAHPLSCSIIAEILGIPSSDIHRFRRWSDELSTVLAAHGPIEHQVACAQGVVEFQRYLASTLKEREVSPREDLLSDIVTGAQGMTPPMSMAELVSLLMQVHFAGHETTAGLIVGAVELLLEHPEQLRALRDDPGLIAGAVEEAVRMISPVHAMFRTALEAVEIGGVPIPKGAHIRIVYASANRDEARFHEPERFDIRRPEVKKHLAFGQGLHFCIGAPLARLEARLAVEALLRSLPGLRLVPGQKPGFLRSVTVRRHESLEVAWDVQANQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2W6</accession>
    <name>Q1D2W6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554832.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4846"/>
    <dbReference type="EnsemblBacteria" id="ABF87316">
        <property type="protein sequence ID" value="ABF87316"/>
        <property type="gene ID" value="MXAN_4846"/>
    </dbReference>
    <dbReference type="GeneID" id="41362142"/>
    <dbReference type="KEGG" id="mxa:MXAN_4846"/>
    <dbReference type="HOGENOM" id="CLU_129267_0_0_7"/>
    <dbReference type="OMA" id="TRIPWLA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="15269" checksum="61A492469A5951AA" modified="2006-07-11" version="1">MVDVGVVGPNPEQFEEFARLLLDAVTSRNYALLAALVVVVLVYLLRKFGGGFIPFFNTDRGGAVLVLGVSLAGAVANALAAGAPFSLALMLTALQVALTAAGGFTIIKRILFGSAAIARAELAGAIAAGQVAEKAAAIAVLEQLDSRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z7</accession>
    <name>Q1D2Z7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554801.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4815"/>
    <dbReference type="EnsemblBacteria" id="ABF92962">
        <property type="protein sequence ID" value="ABF92962"/>
        <property type="gene ID" value="MXAN_4815"/>
    </dbReference>
    <dbReference type="GeneID" id="41362114"/>
    <dbReference type="KEGG" id="mxa:MXAN_4815"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142879_2_0_7"/>
    <dbReference type="OMA" id="RDAAWQP"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13589" checksum="BAA8D65A4E268BF4" modified="2006-07-11" version="1">MRVEIRARNIPLTETLRTYAERRVRFALDRLSDRVKEVVVRLEDANGPKGGVDQVCRVALRLEHGRELAIESSDTNLLAAIDRTLERASNAVTRAVGRAQRQDGTRLRDAAWQPEEAAALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D373</accession>
    <name>Q1D373_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554725.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4738"/>
    <dbReference type="EnsemblBacteria" id="ABF91742">
        <property type="protein sequence ID" value="ABF91742"/>
        <property type="gene ID" value="MXAN_4738"/>
    </dbReference>
    <dbReference type="GeneID" id="41362037"/>
    <dbReference type="KEGG" id="mxa:MXAN_4738"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_7"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="5">
        <location>
            <begin position="120"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="39281" checksum="731053361D40DF94" modified="2006-07-11" version="1">MRNPATLEAPEVLTASAKVDVRDNATALALCGNQNENLKLMERRLGVRVGQRGTEFHLSGPSDAVAFSVRLLENLEEMIRAGRPVYREDVEQGIKVLGRGAESLQEVMLGPVLKSSGNRQISPKSINQKRYVDAIRSHDIVFGIGPAGTGKTYLAMAMAVAFLQERKVKRIILARPAVEAGEKLGFLPGDLQEKVNPYLRPLYDALHDMMAAERAAQLLEQGVVEVAPLAFMRGRTLNDAFVILDEAQNTTVEQMKMFLTRLGYNSKAVITGDVTQVDLPTGKMSGLNHARAVLKNIDGIHFAEFSEVDVVRHPLVQEVIRAYDRADVAQREAQAAREAATAAAHAPAATPATATEPVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M9</accession>
    <name>Q1D3M9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4576</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4576"/>
    <dbReference type="EnsemblBacteria" id="ABF91244">
        <property type="protein sequence ID" value="ABF91244"/>
        <property type="gene ID" value="MXAN_4576"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4576"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_0_2_7"/>
    <dbReference type="OMA" id="SFMSQSG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="520"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="760"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="916" mass="99242" checksum="F9C872A5B607E60F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3N7</accession>
    <name>Q1D3N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554563.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4568"/>
    <dbReference type="EnsemblBacteria" id="ABF91444">
        <property type="protein sequence ID" value="ABF91444"/>
        <property type="gene ID" value="MXAN_4568"/>
    </dbReference>
    <dbReference type="GeneID" id="41361869"/>
    <dbReference type="KEGG" id="mxa:MXAN_4568"/>
    <dbReference type="eggNOG" id="ENOG5031DJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979017_0_0_7"/>
    <dbReference type="OMA" id="FACNVAR"/>
    <dbReference type="OrthoDB" id="1009339at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188198" evidence="2">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="29318" checksum="78F99857A099EDD4" modified="2006-07-11" version="1">MRVDRRYVLTGTLALALWAVACNGGNGPGPGAPRDAGTDGGRTPTVDGGGTDADGGARDFACNVARQEGCADGQDCYFADLADGGTGSRCFEAECDVVAQDCAQGQRCTYAMENDVTQRRCVAPGTADEGAPCTLAPSDGRLAYDTCRQGLFCREAPDGAGSGFTCQRLCHATTQCGNTSECNTVLRLDGTKELPLVCGPPSTACTPFGDDCEAPLSCYPSTSGPLCAGSGNRTEGQSCDFSNQCAPGSACVNAGGGLTCRPLCQPGGTPACSTGGCRALDGNPGVGACVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3X0</accession>
    <name>Q1D3X0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90517">
        <property type="protein sequence ID" value="ABF90517"/>
        <property type="gene ID" value="MXAN_4484"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4484"/>
    <dbReference type="HOGENOM" id="CLU_1729425_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="15834" checksum="CDE6AC98C797BBA6" modified="2006-07-11" version="1">MPLGSFLKDRFGSVRPIAKQMRGGHHAHVQSLMLEQHGESVTSGIAVGQELIDGGTVLPGVLVPDLGVSPEDGLVLSGHVLGELLDKILQLHHQSPFSMFLRANNPNSLAYSGSSAQVPSFQRRSVMIALMAATPPSFAAASSTALASAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Y6</accession>
    <name>Q1D3Y6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4466"/>
    <dbReference type="EnsemblBacteria" id="ABF90182">
        <property type="protein sequence ID" value="ABF90182"/>
        <property type="gene ID" value="MXAN_4466"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4466"/>
    <dbReference type="HOGENOM" id="CLU_703638_0_0_7"/>
    <dbReference type="OMA" id="YTSQESG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="392" mass="40267" checksum="F03563F55E0D10EE" modified="2006-07-11" version="1">MPPQADVRRLGAQPRVEPRIQTRDPMRLALLSVLLLGVACSSDKPPMQDGPDAGRGDAGTGTDDAGTRTDDAGSGDAGCEPLASGPGTPLLTGLNTPRRLAADETDLYIAESHSLNPQQPQPGPGRLLRLPRAGGDTVSLATGFRAPDAIAVVSDSVYVLDLDGLWRVDKATGAKDARPLDATVNNVTIGGTDVLPARMGDRDVVVIATSHRRLVRVDASGGNRQELYAGTGYTQVRGARVVGQDVWFLVAAGESPGLYSVPLDGSAPATLRDGTITAGTSLEVTPTHFLVTEGGGGNGRVLRLPREGGAAEVVATDLQGPAFPVELNGTLYFKDVSTGGTGFLRRVSTCTPGALEPVGPEGVGPGGLLVDGDTLLYTSQESGTGGVVGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4D5</accession>
    <name>Q1D4D5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5`-nucleotidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554316.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4313"/>
    <dbReference type="EnsemblBacteria" id="ABF88299">
        <property type="protein sequence ID" value="ABF88299"/>
        <property type="gene ID" value="MXAN_4313"/>
    </dbReference>
    <dbReference type="GeneID" id="41361624"/>
    <dbReference type="KEGG" id="mxa:MXAN_4313"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_5_7"/>
    <dbReference type="OMA" id="TEGPPIW"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
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        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
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        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142721" evidence="2">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="38"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="327"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="532" mass="57722" checksum="E7736E0E051E3E50" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4E3</accession>
    <name>Q1D4E3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid adenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554308.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4305"/>
    <dbReference type="EnsemblBacteria" id="ABF88012">
        <property type="protein sequence ID" value="ABF88012"/>
        <property type="gene ID" value="MXAN_4305"/>
    </dbReference>
    <dbReference type="GeneID" id="41361616"/>
    <dbReference type="KEGG" id="mxa:MXAN_4305"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_12_7"/>
    <dbReference type="OMA" id="VMDLYPC"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="504" mass="55191" checksum="2A585127F6BE92A7" modified="2006-07-11" version="1">MTLDQIVIRAAAKAPESIAIKGPDGTLTYGQLDALANRIARALQELGVKQGDRVGLWTEKSVRAVAAMQGIARLGAAYVPLDPLNPATRTRLILDDCGIDVMVTTTTRASELHNAGVSRLRYLLVDDKGPEICWNRLSGFSSEPLPPHGAGDHDLAYILYTSGSTGTPKGVCISQRNAMAFIEWCHALLGTTPEDRFSNHAPFFFDLSVLDLYAAFMGGASVTLIPEALAFAPEKLVELVLRERFTCWYSVPSALMLMMQEGGLLKHGALPFRAVLFAGEPFPIRHLRPLREHLPQARFFNLYGPTETNVCTFHEVTDISPHRTEPVPIGRASCGNRVWLARPPPGSEEAREEGDGVGELMVEGPTVMLGYWGQPRHGSGPYATGDRCREVPDGTFEYLGRRDNMLKVRGRRIEAGEIEAALLTHPDIREAGVIATGSGLEARLVAFVVSGASKPPSLLKVKKHCAERLPRYMIVDEVRVLPELPRTPNGKLNRRALRELTQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H0</accession>
    <name>Q1D4H0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554281.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4278"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92793">
        <property type="protein sequence ID" value="ABF92793"/>
        <property type="gene ID" value="MXAN_4278"/>
    </dbReference>
    <dbReference type="GeneID" id="41361593"/>
    <dbReference type="KEGG" id="mxa:MXAN_4278"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298058_0_0_7"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="23939" checksum="52CCFA1356CA4903" modified="2006-07-11" version="1">MSTSINSSRRGASSSYLIRKGDTLSELAARFKTSVKELARINNIANPDLIYAGATLRLPGSAGGRATGHSGKDSFDSGKSGPRGSGGASGGGEVSGSGGVAPGQATPAMRRLAEAGRQAALGMGGYNSQGLCATGVSRAIQNAFGIKVWGNGNQIDNNLPRDKFKQVNMSLEQALKIPGLVLTWESTSTRLGSIYGHTAITTGDGHSSASDFIERNTTNSGRTGFKVFMPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4L5</accession>
    <name>Q1D4L5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ORF">MXAN_4233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554236.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4233"/>
    <dbReference type="EnsemblBacteria" id="ABF86933">
        <property type="protein sequence ID" value="ABF86933"/>
        <property type="gene ID" value="MXAN_4233"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
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        <location>
            <begin position="20"/>
            <end position="235"/>
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    </feature>
    <feature type="binding site" evidence="12">
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        <ligand>
            <name>GTP</name>
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        </ligand>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>1</label>
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            <position position="40"/>
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            <name>[4Fe-4S] cluster</name>
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            <position position="42"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
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            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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        <location>
            <position position="76"/>
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        <ligand>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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            <name>S-adenosyl-L-methionine</name>
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            <name>[4Fe-4S] cluster</name>
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            <name>[4Fe-4S] cluster</name>
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            <begin position="266"/>
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            <name>[4Fe-4S] cluster</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="35775" checksum="9CC4DC2E35DBE40D" modified="2006-07-11" version="1">MTTPALQPPPSALAPPLLDAQGRRMTYLRLSITDRCNFRCSYCSPASWGGKRDLLGPEELERITSVFARMGIRRVRLTGGEPLIRPDILDIARRIAAVPGIQHLAITSNASHLERLARPLREAGVTQLNLSLDTLLAETFRRISKQGDFDAVLRGVDAAAGAGYASLKLNVVVMRGVNDEEASALIAYAHARGFTPRFIELMPFGQGTPVPTAELVERLQASGLPLEPEPDDTGDAAGPARYWRAPGGRVGFISPLTQNFCGTCNRVRVASNGDLRSCLGGRAQAPLHQLIRGGASDVELAVAIRRALGDKPEGHRFTEPGNGATLLSMMGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S4</accession>
    <name>Q1D4S4_MYXXD</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ORF">MXAN_4174</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="26913" checksum="A3F9CA5B9C83A478" modified="2006-07-11" version="1">MSQASGAGPLIQVENITRVFHVGGEEVRALRGVSFGINRGEWVAIIGQSGSGKSTMMNVLGCLDTPSSGRYMLNGKDVSRMSDDELAVIRNVEIGFIFQTFQLLPKETALANVELPLVYRGIGARERRERAKAALDKVQLTHRMHHRPNELSGGQRQRVAIARALVSEPSMLLADEPTGNLDSATGEEIVRLFEQLHKGGHTLVLVTHEPKLAARCPRAIRLSDGEIVADGDGRTVAMGTATDVLNAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D543</accession>
    <name>Q1D543_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4052"/>
    <dbReference type="EnsemblBacteria" id="ABF87991">
        <property type="protein sequence ID" value="ABF87991"/>
        <property type="gene ID" value="MXAN_4052"/>
    </dbReference>
    <dbReference type="GeneID" id="41361382"/>
    <dbReference type="KEGG" id="mxa:MXAN_4052"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_7"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="510" mass="55841" checksum="C69A2DADE511616E" modified="2006-07-11" version="1">MDRVTVLRPSGKAGLAARSGERRAIVIGSGFGGLAAAIRLAARGWRVTVLERMDSPGGRANAFQQDGFTFDAGPTVITCPHLLEELWALGGQRMADHVELRPVAPLYRMRFPDGSTFDYHTDREAMRQSVRRLSPRDEAGFLALCARVERMYEAGIGPLMSTPVPDVLSLAPFTPALVRDEAFRSMFGLVSKHIRDERLQQALSFHPLLIGGSPFATASAVYTSIQFVERRWGAFFPVGGTGALVRGLVELLESLGGEVRYGSEVTEIALEGRKATGVRLGDGTGLAADVVVSNADAAWTYRYLVPGHVRKHWTDERINRARYSMSAFLWYFGTRRQYPEVAHHTLLFGKDFRGMFSGLEGPGQPSADPLLYLHRPTATDAALAPSGHDAFYVLAPVPHLGTGAEWKQRAEAFRRELEARLSRTVLPGLGSELMTSRMATPEYFRDELRSFKGAAFSFAPTLWQTTFLRAQARSEDVDCLYMVGAGTHPGAGLPAVLCSAKIVDTVIPPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D568</accession>
    <name>MUTL_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutL</name>
        <name type="ordered locus">MXAN_4026</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554035.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D568"/>
    <dbReference type="SMR" id="Q1D568"/>
    <dbReference type="STRING" id="246197.MXAN_4026"/>
    <dbReference type="EnsemblBacteria" id="ABF90814">
        <property type="protein sequence ID" value="ABF90814"/>
        <property type="gene ID" value="MXAN_4026"/>
    </dbReference>
    <dbReference type="GeneID" id="41361357"/>
    <dbReference type="KEGG" id="mxa:MXAN_4026"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_2_7"/>
    <dbReference type="OMA" id="VRVMACH"/>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000076700" description="DNA mismatch repair protein MutL">
        <location>
            <begin position="1"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <sequence length="619" mass="65220" checksum="AC6DF120DF82A75D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D575</accession>
    <name>Q1D575_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554028.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4018"/>
    <dbReference type="EnsemblBacteria" id="ABF86818">
        <property type="protein sequence ID" value="ABF86818"/>
        <property type="gene ID" value="MXAN_4018"/>
    </dbReference>
    <dbReference type="GeneID" id="41361350"/>
    <dbReference type="KEGG" id="mxa:MXAN_4018"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828545_0_0_7"/>
    <dbReference type="OMA" id="GQFQQGR"/>
    <dbReference type="OrthoDB" id="1248836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188246" evidence="4">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="335" mass="37278" checksum="CBD53756EEE41A77" modified="2006-07-11" version="1">MSRCLPLLFTALMLLAPGATLAQDAGDPEVAALRASFEYGKYAEVMDRAASRIDRGGLDEDDLAELHKLAGLAAFNLGRTDDARRHLRALLRLDPDFSLDPFVVPPPAVAFFDTLKEDMDTELDFLRQERRLRQEREKAEAERRERERLEAEVQRRRAEELASQVTVRTVEKRNFLVNFVPFGAGQFQQGRTSLGIVFAATEGVLAVTSIISFFAYEGLFEERTIDLDNVLDPDGRASVTVRYIPTSRARQRDAWQLLKLSSAAGFYAIYAVGVVDALFHHEDQVVRSTVEPRAEQPAEPSPRSTSARATAPKTYTRVGLYPTRGGLGAGLTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5D5</accession>
    <name>Q1D5D5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">truD</name>
        <name evidence="6" type="ORF">MXAN_3958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553968.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3958"/>
    <dbReference type="EnsemblBacteria" id="ABF90205">
        <property type="protein sequence ID" value="ABF90205"/>
        <property type="gene ID" value="MXAN_3958"/>
    </dbReference>
    <dbReference type="GeneID" id="41361290"/>
    <dbReference type="KEGG" id="mxa:MXAN_3958"/>
    <dbReference type="eggNOG" id="COG0585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_1_7"/>
    <dbReference type="OMA" id="IGYCGLK"/>
    <dbReference type="OrthoDB" id="1490777at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="134"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="544" mass="61438" checksum="0FD96DEED45ECB6F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5J4</accession>
    <name>Q1D5J4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553909.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3899"/>
    <dbReference type="EnsemblBacteria" id="ABF91412">
        <property type="protein sequence ID" value="ABF91412"/>
        <property type="gene ID" value="MXAN_3899"/>
    </dbReference>
    <dbReference type="GeneID" id="41361231"/>
    <dbReference type="KEGG" id="mxa:MXAN_3899"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_7"/>
    <dbReference type="OMA" id="GCESFHA"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="563" mass="62508" checksum="9ADF1A9B64912BB1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L3</accession>
    <name>Q1D5L3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553890.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3880"/>
    <dbReference type="EnsemblBacteria" id="ABF92950">
        <property type="protein sequence ID" value="ABF92950"/>
        <property type="gene ID" value="MXAN_3880"/>
    </dbReference>
    <dbReference type="GeneID" id="41361213"/>
    <dbReference type="KEGG" id="mxa:MXAN_3880"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_6_7"/>
    <dbReference type="OMA" id="FAYRYIS"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="421" mass="44628" checksum="AFDE98DBDFFC53D6" modified="2006-07-11" version="1">MKFLRELRSVLNLTVLVAGLGYFVDLFDITLFGVVRVASLKDIGVTDPADILQSGLLIYNAQMVGMMVGGLLWGVLADKRGRLSVMFGSILLYSFANLANAFAWDVTSYAVLRFLGGVGLAGELGAAITLVAESLPKEKRGLGTTIVATLGMLGIVAAAFLGQHMHWKTAYLTGGFMGLALLFARFKVSESELFSKKMDPARANPLLLLTGGRFIKYICCILIGVPIYFTTGILFTFAPELTAGLNVQGTVTAGNAILYGSIGLTLGDLLAGVFSQWLKSRKRAVAMNLTAGFVLMLVYGLTPGLTSTMVYGLSFLIGITVGYWAVLVTMAAEQFGTNIRGTVATTVPNFVRGSAALAASGFAYLKGEMSVSTAALIVGSICFGLALLALTRLEETFHRDLDYEETANGPQPAAQPSQSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5R3</accession>
    <name>Q1D5R3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
            <ecNumber evidence="3">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tesB</name>
        <name evidence="3" type="ORF">MXAN_3828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553840.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3828"/>
    <dbReference type="EnsemblBacteria" id="ABF87233">
        <property type="protein sequence ID" value="ABF87233"/>
        <property type="gene ID" value="MXAN_3828"/>
    </dbReference>
    <dbReference type="GeneID" id="41361161"/>
    <dbReference type="KEGG" id="mxa:MXAN_3828"/>
    <dbReference type="eggNOG" id="COG1946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_0_0_7"/>
    <dbReference type="OMA" id="SQVWFRT"/>
    <dbReference type="OrthoDB" id="990202at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00189">
        <property type="entry name" value="tesB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="289" mass="31865" checksum="40ED812A4C31FB49" modified="2006-07-11" version="1">MSRVLDELLALLKLEKIEENLFRGRSQDLGFRQLFGGQVLGQALSAGSQTVPAGRHVHSLHGYFLRPGDATLPVVYTVDRVRDGGSITTRRVVAVQKGEPILTMIASFHGDEEGFAHQAPMPEVPGPEALASEQELLSRVSARIPEALREKFLGEKPIEIRPVAPEDPFNPEAQAPIKHVWFRANGDLPEDPQVHRYVLAYASDFNLISTALLPHAASFFQPRILGASLDHALWFHGDLKVSDWLLYSMDSPWAGNARGLSRGSVYTRDGRLVASVAQEGLLRIRKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D640</accession>
    <name>Q1D640_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3696"/>
    <dbReference type="EnsemblBacteria" id="ABF91394">
        <property type="protein sequence ID" value="ABF91394"/>
        <property type="gene ID" value="MXAN_3696"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3696"/>
    <dbReference type="HOGENOM" id="CLU_1863025_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="15164" checksum="E49CD7C1B54B6287" modified="2006-07-11" version="1">MGMLIVHAWGFAVCRPCLCCSSRTGLRGALVAGGRERWRSGEGGRPVDMKTKKDLAVDFINTIRTMEPSALNALIVKEAGEELAQFFLNYSANLISKDPSRVLENTSSLMLMGYLIRTYEEKNTQSTQGTFQSYAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D678</accession>
    <name>Q1D678_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553676.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3658"/>
    <dbReference type="EnsemblBacteria" id="ABF90626">
        <property type="protein sequence ID" value="ABF90626"/>
        <property type="gene ID" value="MXAN_3658"/>
    </dbReference>
    <dbReference type="GeneID" id="41360994"/>
    <dbReference type="KEGG" id="mxa:MXAN_3658"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_7_0_7"/>
    <dbReference type="OMA" id="TERINDM"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="239" mass="26878" checksum="165C91FD5677170B" modified="2006-07-11" version="1">MKREPVTDRLDRVLGLLASRPSWTAPELAEELRVCVRTVRRDLSRLSARGVPIESDAGRGGGIRVPPRTGLGRVQLSAQELLDLLLALALAERLESPLLLSTLKSLRQKLAASFPPEERARVGKLRRRILVGPTSRNVTATWKPPRAAVLRPLQESFFEQHALELTYRSNDVRTVRIVEPHYLLLSWPAWYLLVWDHLRGAVRMLRVDRIESASVQAATFQVRDSKSMLATLGDIFAAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-05-25" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6H4</accession>
    <name>ENCAP_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 1 encapsulin shell protein EncA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">encA</name>
        <name type="ORF">MXAN_3556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="J. Microbiol. Biotechnol." volume="19" first="1288" last="1294">
            <title>Operon required for fruiting body development in Myxococcus xanthus.</title>
            <authorList>
                <person name="Kim D."/>
                <person name="Chung J."/>
                <person name="Hyun H."/>
                <person name="Lee C."/>
                <person name="Lee K."/>
                <person name="Cho K."/>
            </authorList>
            <dbReference type="PubMed" id="19996678"/>
            <dbReference type="DOI" id="10.4014/jmb.0903.0112"/>
        </citation>
        <scope>OPERON STRUCTURE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>DZ2</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2019" name="ACS Nano" volume="13" first="8114" last="8123">
            <title>Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters.</title>
            <authorList>
                <person name="Sigmund F."/>
                <person name="Pettinger S."/>
                <person name="Kube M."/>
                <person name="Schneider F."/>
                <person name="Schifferer M."/>
                <person name="Schneider S."/>
                <person name="Efremova M.V."/>
                <person name="Pujol-Marti J."/>
                <person name="Aichler M."/>
                <person name="Walch A."/>
                <person name="Misgeld T."/>
                <person name="Dietz H."/>
                <person name="Westmeyer G.G."/>
            </authorList>
            <dbReference type="PubMed" id="31194509"/>
            <dbReference type="DOI" id="10.1021/acsnano.9b03140"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2021" name="Nat. Commun." volume="12" first="4748" last="4748">
            <title>Large-scale computational discovery and analysis of virus-derived microbial nanocompartments.</title>
            <authorList>
                <person name="Andreas M.P."/>
                <person name="Giessen T.W."/>
            </authorList>
            <dbReference type="PubMed" id="34362927"/>
            <dbReference type="DOI" id="10.1038/s41467-021-25071-y"/>
        </citation>
        <scope>CLASSIFICATION</scope>
    </reference>
    <reference evidence="9" key="5">
        <citation type="journal article" date="2014" name="EMBO J." volume="33" first="1896" last="1911">
            <title>A virus capsid-like nanocompartment that stores iron and protects bacteria from oxidative stress.</title>
            <authorList>
                <person name="McHugh C.A."/>
                <person name="Fontana J."/>
                <person name="Nemecek D."/>
                <person name="Cheng N."/>
                <person name="Aksyuk A.A."/>
                <person name="Heymann J.B."/>
                <person name="Winkler D.C."/>
                <person name="Lam A.S."/>
                <person name="Wall J.S."/>
                <person name="Steven A.C."/>
                <person name="Hoiczyk E."/>
            </authorList>
            <dbReference type="PubMed" id="25024436"/>
            <dbReference type="DOI" id="10.15252/embj.201488566"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (4.60 ANGSTROMS) OF 1-287</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SEQUENCE REVISION TO N-TERMINUS</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION BY STARVATION</scope>
        <scope>DOMAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 6">Shell component of a type 1, iron-storage encapsulin nanocompartment. Encapsulin nanocompartments are 32 nm in diameter with an iron- and phosphorus-rich core (4Fe:1P) about 24 nm in diameter. Upon expression in E.coli most particles are 32 nm, 20% are 18 nm. The core is filled with an average of 14 dense granules, 5-6 nm in diameter that are not evenly distributed. Each nanocompartment is estimated to hold 30,000-35,000 Fe atoms (PubMed:25024436, PubMed:31194509). The minor proteins EncB, EncC and EncD probably lie against the interior face of the nanocompartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 32 nm encapsulin nanocompartment is formed by 180 subunits; monomers form pentamers which assemble to form shells. There are 36 pores where the pentamers meet as well as 3-fold axis channels and dimer channels. The N-terminus of the protein is inside the shell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1 2">Part of the MXAN_3553-MXAN_3554-MXAN_3555-encA operon (PubMed:19996678). Expression is induced by amino acid starvation (at protein level). Not present in spores (at protein level) (PubMed:25024436).</text>
    </comment>
    <comment type="domain">
        <text evidence="2">Has 3 domains; a discontinuous peripheral domain (P), an elongated loop (E) and the discontinuous axial domain (A).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="1 2">Does not form fruiting bodies (PubMed:19996678). Decreased survival when grown under oxidative stress (0.5 mM H2O2) (PubMed:25024436).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">The encapsulin and a cargo construct (an encB-encC-encD fusion) can be overexpressed in E.coli and in human HEK293T cells. In HEK293T in the presence of 0.5 M ferrous ammonium sulfate nanocompartments can be detected and used as cell markers. Coexpression of this nanocompartment with a larger nanocompartment from Q.thermotolerans (AC A0A0F5HPP7) allows expression of different sized iron-rich particles. The encapsulin shell proteins do not seem to mix.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">Shows substantial structural similarity to gp5 of the HK97 viral capsid, and while the sequence homology is weak, it suggests this protein may have evolved from a viral capsid protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF87797" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87797.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="4PT2">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.60 A"/>
        <property type="chains" value="A/B/P=1-287"/>
    </dbReference>
    <dbReference type="PDB" id="7S20">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A/B/C=1-287"/>
    </dbReference>
    <dbReference type="PDB" id="7S21">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A=1-287"/>
    </dbReference>
    <dbReference type="PDB" id="7S2T">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.45 A"/>
        <property type="chains" value="A/B/C=1-287"/>
    </dbReference>
    <dbReference type="PDB" id="7S4Q">
        <property type="method" value="EM"/>
        <property type="resolution" value="3.12 A"/>
        <property type="chains" value="A/B/C=1-287"/>
    </dbReference>
    <dbReference type="PDBsum" id="4PT2"/>
    <dbReference type="PDBsum" id="7S20"/>
    <dbReference type="PDBsum" id="7S21"/>
    <dbReference type="PDBsum" id="7S2T"/>
    <dbReference type="PDBsum" id="7S4Q"/>
    <dbReference type="SMR" id="Q1D6H4"/>
    <dbReference type="IntAct" id="Q1D6H4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q1D6H4"/>
    <dbReference type="STRING" id="246197.MXAN_3556"/>
    <dbReference type="EnsemblBacteria" id="ABF87797">
        <property type="protein sequence ID" value="ABF87797"/>
        <property type="gene ID" value="MXAN_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3556"/>
    <dbReference type="eggNOG" id="COG1659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089875_0_0_7"/>
    <dbReference type="OMA" id="DSDWQPV"/>
    <dbReference type="BRENDA" id="1.16.3.1">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140737">
        <property type="term" value="C:encapsulin nanocompartment"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0409">Iron storage</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000455315" description="Type 1 encapsulin shell protein EncA">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="19996678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="25024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="31194509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="25024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="25024436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="4PT2"/>
        </source>
    </evidence>
    <sequence length="287" mass="31656" checksum="5F3BDD27DB2B55E4" modified="2022-05-25" version="2">MPDFLGHAENPLREEEWARLNETVIQVARRSLVGRRILDIYGPLGAGVQTVPYDEFQGVSPGAVDIVGEQETAMVFTDARKFKTIPIIYKDFLLHWRDIEAARTHNMPLDVSAAAGAAALCAQQEDELIFYGDARLGYEGLMTANGRLTVPLGDWTSPGGGFQAIVEATRKLNEQGHFGPYAVVLSPRLYSQLHRIYEKTGVLEIETIRQLASDGVYQSNRLRGESGVVVSTGRENMDLAVSMDMVAAYLGASRMNHPFRVLEALLLRIKHPDAICTLEGAGATERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6T8</accession>
    <name>Q1D6T8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3438"/>
    <dbReference type="EnsemblBacteria" id="ABF89452">
        <property type="protein sequence ID" value="ABF89452"/>
        <property type="gene ID" value="MXAN_3438"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3438"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241130_0_0_7"/>
    <dbReference type="OMA" id="DHAIECM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1692" mass="186210" checksum="D6D77A6BEFCE4736" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7T6</accession>
    <name>Q1D7T6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Social gliding motility protein Tgl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tgl</name>
        <name evidence="3" type="ORF">MXAN_3084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553134.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3084"/>
    <dbReference type="EnsemblBacteria" id="ABF91718">
        <property type="protein sequence ID" value="ABF91718"/>
        <property type="gene ID" value="MXAN_3084"/>
    </dbReference>
    <dbReference type="GeneID" id="41360446"/>
    <dbReference type="KEGG" id="mxa:MXAN_3084"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_9_0_7"/>
    <dbReference type="OMA" id="SYHYQMG"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187971" evidence="2">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="28285" checksum="AE83C779779FF188" modified="2006-07-11" version="1">MFRLSTASCSLALLLVSSGCSHTPTEKEKRSAEIHYDLALQAQQAGELQDALRELQVSLKNDPDYPDANNAMGILLHLAFRRPDEAVKHYTKALEVRPDFSEARTNLANVHLDQGRYDDAIKLYELVLNDMLYPTPFIAQGNLGWAYYKKGEPDRAVESIKAAVTTNPNFCLGYKNLGLIYDETGRTSEACRQFTHYRENCPDVAEAYMREGVCQAKLGQVDAAKAAFATCETKAKAGEQVLKDDCRRLLEKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U4</accession>
    <name>RL7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">MXAN_3076</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553126.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7U4"/>
    <dbReference type="SMR" id="Q1D7U4"/>
    <dbReference type="STRING" id="246197.MXAN_3076"/>
    <dbReference type="EnsemblBacteria" id="ABF91863">
        <property type="protein sequence ID" value="ABF91863"/>
        <property type="gene ID" value="MXAN_3076"/>
    </dbReference>
    <dbReference type="GeneID" id="41360438"/>
    <dbReference type="KEGG" id="mxa:MXAN_3076"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_7"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000007043" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="122" mass="12503" checksum="EBB60BEE3FAD14A1" modified="2006-07-11" version="1">MADLNAIVDQLSSLTVLEAAELVKQLESKWGVSAAAVAVAAGPAAAAAPVEEKTEFTVVLANAGANKINVIKEIRAITGLGLKEAKDLVEGAPKNVKEGVNKDDAKKIKDQLTAAGATVDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D806</accession>
    <name>Q1D806_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adventurous gliding motility protein AglU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aglU</name>
        <name evidence="3" type="ORF">MXAN_3008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553064.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3008"/>
    <dbReference type="EnsemblBacteria" id="ABF89413">
        <property type="protein sequence ID" value="ABF89413"/>
        <property type="gene ID" value="MXAN_3008"/>
    </dbReference>
    <dbReference type="GeneID" id="41360369"/>
    <dbReference type="KEGG" id="mxa:MXAN_3008"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_511584_0_0_7"/>
    <dbReference type="OMA" id="RMDSDTY"/>
    <dbReference type="OrthoDB" id="190378at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187975" evidence="2">
        <location>
            <begin position="22"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="547" mass="57535" checksum="7564049D77DEF509" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8M3</accession>
    <name>Q1D8M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2783"/>
    <dbReference type="EnsemblBacteria" id="ABF92498">
        <property type="protein sequence ID" value="ABF92498"/>
        <property type="gene ID" value="MXAN_2783"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2783"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="SYPAFFM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="303"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="414"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="800" mass="85747" checksum="A4DD311003691423" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8N5</accession>
    <name>Q1D8N5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein, GvpL/GvpF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552838.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2771"/>
    <dbReference type="EnsemblBacteria" id="ABF90032">
        <property type="protein sequence ID" value="ABF90032"/>
        <property type="gene ID" value="MXAN_2771"/>
    </dbReference>
    <dbReference type="GeneID" id="41360148"/>
    <dbReference type="KEGG" id="mxa:MXAN_2771"/>
    <dbReference type="eggNOG" id="ENOG50335UX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065736_3_1_7"/>
    <dbReference type="OMA" id="WPPYHFV"/>
    <dbReference type="OrthoDB" id="1869432at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="28433" checksum="B30CAD415B1DB4F7" modified="2006-07-11" version="1">MKSIMYGILDARQAAKESLPPGLNQAPLMAVKHGNLAAAISPVEEELASSAGIEQALEYARVVEQLHRRLSVLPMRYGCFVHHPEQVVEFLHRYERQFSDALAQVEGCDEMGLRILFQESDVAEPPEQAGAPTGADAQTRGRAYLDNRRRFYAQQTRVDRAARRMAERAQAAFSGQFVRCTWDHAARPDGQLLSMAFLVERPKLAEFRRAFLRFQKDGPGNVMCSGPWPPYGFVADLAKPAVAALAELEHLQEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8S9</accession>
    <name>Q1D8S9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="8" type="ORF">MXAN_2727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552794.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2727"/>
    <dbReference type="EnsemblBacteria" id="ABF90631">
        <property type="protein sequence ID" value="ABF90631"/>
        <property type="gene ID" value="MXAN_2727"/>
    </dbReference>
    <dbReference type="GeneID" id="41360104"/>
    <dbReference type="KEGG" id="mxa:MXAN_2727"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_0_7"/>
    <dbReference type="OMA" id="FTWVERR"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="482" mass="51892" checksum="A7F10301724C1499" modified="2006-07-11" version="1">MSRVLTILVAMFTIVFLMAGGMASAYLVGGLVEEHWFTGASRLTNVLFLVLIFVMVIATLLTMAERKWSAFIQDRMGPNRARIALPGLKNRPLGGLPHILTDVLKMLTKEDLIPAAANRFMFNLGPILAFAPTFALFAVVPAGPSVQVFGRNVDMVVATPDFGALYVLAIASLAVYGTALAGWASNNKFGLLGGVRATSQMIAYEVALGLSLVGIFLTFSSVQFPAIIGDIGNALTGGTGQGRYLWRTDGAFDLGLPAWGIFIQPLGFLLFFAASFAETKRAPFDLPEGESEIIGYFVEYSGMKFGLFMISEFVEVVVLAGVTTAFFFGGYHLPFGNEWLANLPIMQEHGWLLGTILGTVFWLKVLFLIWVQLLIRWTFPRFRYDQIQSLGWKILLPLGLVNVFVTGALVLWDPSLRALAVLGIAEIGILVVLTTTTKVPAGGAHGAHAGHGHDHGHGHAHGGHGAHDLPAHAHGVAPASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8T1</accession>
    <name>Q1D8T1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2725"/>
    <dbReference type="EnsemblBacteria" id="ABF86670">
        <property type="protein sequence ID" value="ABF86670"/>
        <property type="gene ID" value="MXAN_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2725"/>
    <dbReference type="HOGENOM" id="CLU_3390402_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="32" mass="3629" checksum="5235665FF2A166CA" modified="2006-07-11" version="1">MKRKAGRRFFRGLVVKLNLFNTLDGGLPETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D965</accession>
    <name>Q1D965_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HesB/YadR/YfhF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2589"/>
    <dbReference type="EnsemblBacteria" id="ABF92931">
        <property type="protein sequence ID" value="ABF92931"/>
        <property type="gene ID" value="MXAN_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2589"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_7"/>
    <dbReference type="OMA" id="ARENCAC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="108" mass="11361" checksum="ECE67DA944FC97B3" modified="2006-07-11" version="1">MAVRLTDAAIQQVKSVITAQGFEGYFFSIRVVPAGCSGLGYDLNLVKESKAGDTVWEQDGVKIASDPMSSQYLGGTEIDYVSAITGSGFKFNNPNAKSSCGCGTSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAB8</accession>
    <name>Q1DAB8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R2K_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552260.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86090">
        <property type="protein sequence ID" value="ABF86090"/>
        <property type="gene ID" value="MXAN_2181"/>
    </dbReference>
    <dbReference type="GeneID" id="41359574"/>
    <dbReference type="KEGG" id="mxa:MXAN_2181"/>
    <dbReference type="HOGENOM" id="CLU_2807938_0_0_7"/>
    <dbReference type="OrthoDB" id="1881710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041261">
        <property type="entry name" value="R2K_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18299">
        <property type="entry name" value="R2K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R2K_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="67" mass="7147" checksum="7DB3BAFDEC8E11EF" modified="2006-07-11" version="1">MTLRAEARAFLDTVARSPMLPRTCVLDAAWVEDRGWVLLEANAAWGAGLNGCDAAEAARCIAEATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAN1</accession>
    <name>Q1DAN1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552147.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2063"/>
    <dbReference type="EnsemblBacteria" id="ABF88061">
        <property type="protein sequence ID" value="ABF88061"/>
        <property type="gene ID" value="MXAN_2063"/>
    </dbReference>
    <dbReference type="GeneID" id="41359472"/>
    <dbReference type="KEGG" id="mxa:MXAN_2063"/>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738539_0_0_7"/>
    <dbReference type="OMA" id="FENDKVR"/>
    <dbReference type="OrthoDB" id="1616477at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188350" description="FecR domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="16811" checksum="C06643BCEAAD6068" modified="2006-07-11" version="1">MNGRRWSPMLLALALSALPAGCTADERPSAPDAATPPTVATHRAHLRAMKGGVQIKRATADEWSPAREGQPLYENDKVRTEAGAGTDIVFAANGSTVHLTGDSLISIAETRTRPGQQRTDLTVLRGRIDAELEKPATQSLSVTTPSATIQAGREIVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAQ7</accession>
    <name>Q1DAQ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92109">
        <property type="protein sequence ID" value="ABF92109"/>
        <property type="gene ID" value="MXAN_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2038"/>
    <dbReference type="HOGENOM" id="CLU_518589_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="525" mass="56121" checksum="6935EC42F0ECACA3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAU9</accession>
    <name>Q1DAU9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1990"/>
    <dbReference type="EnsemblBacteria" id="ABF86428">
        <property type="protein sequence ID" value="ABF86428"/>
        <property type="gene ID" value="MXAN_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1990"/>
    <dbReference type="eggNOG" id="ENOG50319F1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618029_0_0_7"/>
    <dbReference type="OMA" id="QRCANCM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="18684" checksum="2CC15175665DDB66" modified="2006-07-11" version="1">MSQVVKDKGTRPDKADLVAQEKAARELVSSLGKREFLEQFQKLAKSFASDPGNPGSYACEGCQRCANCMFCKDCDSCFSCTHCTRCELCNNCSHCVDCKSCNACAYCVQSENCSTSAYLVLCRNLQDCNYCFGCVGLAKKDFHILNVPFPRTEYFKIVGRLRKELGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAW9</accession>
    <name>Q1DAW9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552059.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1969"/>
    <dbReference type="EnsemblBacteria" id="ABF91988">
        <property type="protein sequence ID" value="ABF91988"/>
        <property type="gene ID" value="MXAN_1969"/>
    </dbReference>
    <dbReference type="GeneID" id="41359380"/>
    <dbReference type="KEGG" id="mxa:MXAN_1969"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952217_0_0_7"/>
    <dbReference type="OMA" id="HATCAYP"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="79"/>
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        </location>
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    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91988.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="34232" checksum="26C23DE56D29274B" modified="2006-07-11" version="1">MSMPGTRPVLSRRDALPVPQQSRTGRSMATPTHTPTLHELLAGKRFGLVLSAGYFGFYGHAGFLKGLAAAGLSPHAYAGTSAGGMVAAYAAAGTPVRDVEELVLRQTRANFWDPDPIGAVLNADAAGHGLTGLLKGERFRKLLDATLPVRTFEELPHPLLLVGANLTLGSHDVFTSGELAPRVHATCAYPGLFRAVPLEGSLYWDGGLVDKAPALSLHESAVGAELDAILVHYLPSKTRKVVGGPMAYAQGLAAGSAALRQDHFRLQLTVLEQKQVPVYVVVSNLPPVSPTTMERGFDALDQAKLGAERALARPPVPFAQAEW</sequence>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
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    <dbReference type="EMBL" id="CP000113">
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    <dbReference type="STRING" id="246197.MXAN_1957"/>
    <dbReference type="EnsemblBacteria" id="ABF92497">
        <property type="protein sequence ID" value="ABF92497"/>
        <property type="gene ID" value="MXAN_1957"/>
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    <dbReference type="KEGG" id="mxa:MXAN_1957"/>
    <dbReference type="HOGENOM" id="CLU_2539031_0_0_7"/>
    <dbReference type="OMA" id="FDACGCG"/>
    <dbReference type="OrthoDB" id="2090468at2"/>
    <dbReference type="Proteomes" id="UP000002402">
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
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        <source>
            <dbReference type="EMBL" id="ABF92497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="83" mass="8737" checksum="3C9F21BFBE349B3D" modified="2006-07-11" version="1">MFDLRGVLTLLTALGAAGCGALTEEGDAAEVSQPVADRAACDAQAAQRRYVSEDRKECQVVFFVCARGESPFFDACGCGCSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY9</accession>
    <name>Q1DAY9_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Acyltransferase domain protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">MXAN_1946</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF86343">
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    <dbReference type="OMA" id="PIPTDGY"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="111"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="35232" checksum="B44E98DD5DA3011D" modified="2006-07-11" version="1">MSVGHACHARARASADGPSRRRGRWCKEPPMLENVTDRVKKGLREWTDRLANTEQKQRLHGLSRPGNEYGVDPFGFDLDYSLSAVAPLLWLYRNYFRVETFGIENVPAGRVLLVSNHSGQLPMDGAMIGVAMMLDASPSRVIRSMVEKWVSSLPYVSTFMARVGQIVGTPENCRRLLESEEAILVFPEGTRGINKLWPQRYQLQEFGLGFMRLALETNTPIVPVAVIGAEEQAPALMDLKPVAKLLGFPSFPITPTGLPIPLPTKYRIYFGEPLHFSGRPDDEDSELDKKVRTVKASIQSMLHQGLKERQGVFW</sequence>
</entry>
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    <accession>Q1DB04</accession>
    <accession>Q50884</accession>
    <name>MGLA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Mutual gliding-motility protein MglA</fullName>
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    </protein>
    <gene>
        <name type="primary">mglA</name>
        <name type="ordered locus">MXAN_1925</name>
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    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="J. Bacteriol." volume="171" first="819" last="830">
            <title>Gliding motility in Myxococcus xanthus: mgl locus, RNA, and predicted protein products.</title>
            <authorList>
                <person name="Stephens K."/>
                <person name="Hartzell P."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="2464581"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="submission" date="2002-12" db="EMBL/GenBank/DDBJ databases">
            <title>Identification of genes required for adventurous gliding motility in Myxococcus xanthus with the transposable element mariner.</title>
            <authorList>
                <person name="Hartzell P.L."/>
                <person name="Youderian P.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1991" name="J. Bacteriol." volume="173" first="7615" last="7624">
            <title>Function of MglA, a 22-kilodalton protein essential for gliding in Myxococcus xanthus.</title>
            <authorList>
                <person name="Hartzell P.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="1938957"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="2593" last="2601">
            <title>Gliding mutants of Myxococcus xanthus with high reversal frequencies and small displacements.</title>
            <authorList>
                <person name="Spormann A.M."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="10198026"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="46" first="1399" last="1413">
            <title>MglA, a small GTPase, interacts with a tyrosine kinase to control type IV pili-mediated motility and development of Myxococcus xanthus.</title>
            <authorList>
                <person name="Thomasson B."/>
                <person name="Link J."/>
                <person name="Stassinopoulos A.G."/>
                <person name="Burke N."/>
                <person name="Plamann L."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="12453225"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2002.03258.x"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Bacteriol." volume="186" first="6168" last="6178">
            <title>AglZ is a filament-forming coiled-coil protein required for adventurous gliding motility of Myxococcus xanthus.</title>
            <authorList>
                <person name="Yang R."/>
                <person name="Bartle S."/>
                <person name="Otto R."/>
                <person name="Stassinopoulos A.G."/>
                <person name="Rogers M."/>
                <person name="Plamann L."/>
                <person name="Hartzell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="15342587"/>
            <dbReference type="DOI" id="10.1128/JB.186.18.6168-6178.2004"/>
        </citation>
        <scope>INTERACTION WITH AGLZ</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">Required for multicellular development and for both mechanisms of gliding: social (S) and adventurous (A) motility. Acts as an intracellular switch to coordinate A and S motilities. Controls the direction of gliding and gliding speed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with MasK and AglZ.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-7643442">
            <id>Q1DB04</id>
        </interactant>
        <interactant intactId="EBI-8019001">
            <id>Q1DB03</id>
            <label>mglB</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family. MglA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF377950">
        <property type="protein sequence ID" value="AAA25389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY197569">
        <property type="protein sequence ID" value="AAO66302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B32048">
        <property type="entry name" value="B32048"/>
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    <dbReference type="RefSeq" id="WP_011552025.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="5YMX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.35 A"/>
        <property type="chains" value="A/B=1-195"/>
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    <dbReference type="PDB" id="6H17">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.27 A"/>
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        <property type="resolution" value="2.30 A"/>
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    <dbReference type="PDB" id="6H5B">
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        <property type="resolution" value="2.80 A"/>
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    <dbReference type="PDB" id="6HJH">
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.98 A"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A=1-195"/>
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    <dbReference type="PDBsum" id="6HJO"/>
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    <dbReference type="AlphaFoldDB" id="Q1DB04"/>
    <dbReference type="SMR" id="Q1DB04"/>
    <dbReference type="IntAct" id="Q1DB04">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="MINT" id="Q1DB04"/>
    <dbReference type="STRING" id="246197.MXAN_1925"/>
    <dbReference type="EnsemblBacteria" id="ABF87984">
        <property type="protein sequence ID" value="ABF87984"/>
        <property type="gene ID" value="MXAN_1925"/>
    </dbReference>
    <dbReference type="GeneID" id="41359339"/>
    <dbReference type="KEGG" id="mxa:MXAN_1925"/>
    <dbReference type="eggNOG" id="COG1100">
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    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000282836" description="Mutual gliding-motility protein MglA">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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            <end position="128"/>
        </location>
    </feature>
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            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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            <end position="82"/>
        </location>
        <ligand>
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            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
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        </ligand>
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            <begin position="3"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="25"/>
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        </location>
    </feature>
    <feature type="strand" evidence="6">
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        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="70"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
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            <end position="85"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="strand" evidence="6">
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        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
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            <end position="109"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
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            <end position="125"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="15342587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="1938957"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="195" mass="22015" checksum="B68657C5110C820E" modified="2006-07-11" version="1">MSFINYSSREINCKIVYYGPGLCGKTTNLQYIYNKTAAETKGKLISLSTETDRTLFFDFLPLSLGEIRGFKTRFHLYTVPGQVFYDASRKLILKGVDGVVFVADSQIERMEANMESLENLRINLAEQGYDLNKIPYVIQYNKRDLPNAVTVEEMRKALNHRNIPEYQAVAPTGVGVFDTLKAVAKLVLTELKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB37</accession>
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            <fullName evidence="2">DUF2379 domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="21154" checksum="1AC95690F38EDD3D" modified="2006-07-11" version="1">MKPSATRSGQAAPSAPIRGERDPSLGLTRRAGQPAKETCIVSKTIDWGPIRTLARRVLTEGERVALTRKEKALLRRTAAEVGISASEVESALATEEGALGLLQEESRRISEGTRRLMDALHRMYEHKDKGDLDSARQEMRNVLAVEVVPHYRAIAQGQLEAMADEHQQGERAPGASTRAVFARRTPLRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBA6</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">MXAN_1821</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
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    </dbReference>
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            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="318" mass="34635" checksum="41BCF61158494E6F" modified="2006-07-11" version="1">MKTLRFGIEIETVGASRQKLAHAIQSAVGGHVSGDYRGWQVTDTQGRIWRVVSDASLSGGEYSGEIVSPILTYQDMDALQQVVRAAREAGARADASTGIHIHVDGSRFDAKGVTNLVKMVHKQERLLETALGVSAARLARYCRPIDGAFLQRLEARRPRTLQDVNEAWYGRRNSMPNRYDSSRYHGLNLNSLFFRGTIEFRYFNGSVHAGEVKAYVQLVLALAARALASKAASSKRRDFNPATAKYDFRVFLLHLGLIGEEFKTARLHLLKKLEGSAAWKGQRRDRRGSGGGEDGSTGSEGTQGGAGGSAPTEALAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBA9</accession>
    <name>Q1DBA9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Kaiser D."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF87828">
        <property type="protein sequence ID" value="ABF87828"/>
        <property type="gene ID" value="MXAN_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1818"/>
    <dbReference type="eggNOG" id="ENOG5031DEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2569106_0_0_7"/>
    <dbReference type="OMA" id="MVIVMRD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="9870" checksum="588DDB71FC6424AD" modified="2006-07-11" version="1">MLASTPTGEEAMVIVMRDGRVLQGTAVQIVKGMQDIAFGVERLSLGEYIDWVVGNAQRFESVALRVQGETDEEKAASLVDEMLREGLATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBM1</accession>
    <name>Q1DBM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dyp-type peroxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551811.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1701"/>
    <dbReference type="PeroxiBase" id="5545">
        <property type="entry name" value="MxDyPrx"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90727">
        <property type="protein sequence ID" value="ABF90727"/>
        <property type="gene ID" value="MXAN_1701"/>
    </dbReference>
    <dbReference type="GeneID" id="41359139"/>
    <dbReference type="KEGG" id="mxa:MXAN_1701"/>
    <dbReference type="eggNOG" id="COG2837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015125_2_1_7"/>
    <dbReference type="OMA" id="FHELGNE"/>
    <dbReference type="OrthoDB" id="837319at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="47557" checksum="012871E32C279446" modified="2006-07-11" version="1">MLELDDIQSGVLRPRPSPYVATYILLRIDDRSAGRELMGRLCSVVATAAHPSSPTADCWLSVALTYHGLEALGVPRNSLDSFAWEFRQGMAARAKALGDDGESSPEHWEPPLGTSDVHVVLTALSPTQAQLETALERASKAVRELGGIEAIWRQDCHALSTGKEPFGFKDGISHPAVEGSGIPGSNPHEEPLKAGEFVLGYPDETGGVSPMPWPDVLGRNGTYVAFRKLHQRVAAFRQYLKATASSREDEEFLAAKMMGRWRSGAPLALCPHHDAPDLGADSSRNNAFLYSDDPTGYKTPPASHVRRANPRDASVAGVVRLHRMIRRGTAYGPELPEGILEDDGAERGLMFAFIGAHLGRQFEFVQSEWVNGGDFLGLGDAKDPLVGANDGTGVFSVPKRPIPRRMQGLPRFVVTRGGEYCFMPGLRALRWLADLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBS8</accession>
    <name>Q1DBS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551754.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1643"/>
    <dbReference type="EnsemblBacteria" id="ABF92292">
        <property type="protein sequence ID" value="ABF92292"/>
        <property type="gene ID" value="MXAN_1643"/>
    </dbReference>
    <dbReference type="GeneID" id="41359085"/>
    <dbReference type="KEGG" id="mxa:MXAN_1643"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_4_0_7"/>
    <dbReference type="OMA" id="GCLVEQA"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16176" checksum="24E198D471C6AF83" modified="2006-07-11" version="1">MRRDSRLSVALHVLLHMEDMGPVVTSEAMGRLLKANPVVVRRTMAGLREAGILTSVKGHGGGWSLARTLDTVTLGDVYEALGTPGLFSIGPHDESPGCLVEQAVNDALGKALDQAAALLMQHLRSTSVADLGRGVRRRHARAAKRRVKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBW6</accession>
    <name>Q1DBW6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551716.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1605"/>
    <dbReference type="EnsemblBacteria" id="ABF91870">
        <property type="protein sequence ID" value="ABF91870"/>
        <property type="gene ID" value="MXAN_1605"/>
    </dbReference>
    <dbReference type="GeneID" id="41359050"/>
    <dbReference type="KEGG" id="mxa:MXAN_1605"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_6_7"/>
    <dbReference type="OMA" id="LDVSTWE"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="323"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="430" mass="45073" checksum="BB59E54103318551" modified="2006-07-11" version="1">MRALLQIAFRNLLAHRERGLLLLIVLAGASAVLVGVMSVSAGVARAQREAVRTFLAGDLNVGGYFKEHPDSIFPVVGDTSRVRSVLQPHVPAECQVRERGRGSATAGAGRHRVRSYLMSLDVAAEGNAGFRVRTGSLEALAKPRTVALSTSLAERLQVEVGELATLFVQMPGGKRNAVDVEVVALLERAGVLGESAGLLVSNAMLRELYGFRPDSASVIQLLCGDGTELEPLAGTLRGALQKAGYEVLPPAHEAYGDKLGPLLREGWAGQKLDVSTWEDEAAFLDFVGQGLGLLLVLVGAVVFGVVVVGLFVSLNVSVRERTREIGTLRAMGMQRRSLVAAFMLEGLLVGWAASLVGAGMAAGLGVLLRDVLPVPDALSTLFFSGTLPLAPTLGHVVAAVLLVTLGAGLASIVPAFRAASLPPRSAMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC03</accession>
    <name>Q1DC03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LamB/YcsF family/allophanate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551679.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1568"/>
    <dbReference type="EnsemblBacteria" id="ABF89104">
        <property type="protein sequence ID" value="ABF89104"/>
        <property type="gene ID" value="MXAN_1568"/>
    </dbReference>
    <dbReference type="GeneID" id="41359013"/>
    <dbReference type="KEGG" id="mxa:MXAN_1568"/>
    <dbReference type="eggNOG" id="COG1540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640644_0_0_7"/>
    <dbReference type="OMA" id="ITEEHAC"/>
    <dbReference type="OrthoDB" id="1848526at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="233"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="432" mass="45727" checksum="A7724E257607B3FB" modified="2006-07-11" version="1">MRRMTECLLNVDLGELPGEDEQLYALAHVANIACGGHAGDDASMRRALERCERHGTRVGAHPSYEDREGFGRRALDVTPEHLRAQVAAQCGRLAKLAADRHLPVAYAKPHGALYHAANATPALARAVVAGIVEALGTAVTFIGPGTGALHDAALAAGLAYAREGFADRGTRPDGSLIPRGQPGAVLTDHAQARANTVRLATSGSVDTVCVHGDTPGAVELAREVRATLDALALRAEPLGEGALRLVLPEGLERRATREALCAMPGVLDAVITEEHACVYFAPDAPPEEPRLALARLLRIPAPVAGRPLTTISVRYDGQDLHAVAERAGLTEDEVARRHTAREYTVRCVGFLPGFAYLGEVDPSIAVPRLATPRTRVPALAVGIAGGRTGVYPFASPGGWNLIGTALDFTAFTPEEGSVLQLGDRVRFKRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC61</accession>
    <name>Q1DC61_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551621.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87418">
        <property type="protein sequence ID" value="ABF87418"/>
        <property type="gene ID" value="MXAN_1510"/>
    </dbReference>
    <dbReference type="GeneID" id="41358956"/>
    <dbReference type="KEGG" id="mxa:MXAN_1510"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244216_0_0_7"/>
    <dbReference type="OMA" id="QDAVGKF"/>
    <dbReference type="OrthoDB" id="1040310at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="25470" checksum="F47BE889363B2C64" modified="2006-07-11" version="1">MYEQLTDDELFAEVVRRRATGEPVGGPLGALVQRWARPSRYVISKIQASYGRGSPADADELFQDAVGKFIDRGLDQFRGVSEQMPGRSASPKTFFLRIVKHVAIDFYRKHREELAAPPSDPDDAMEEPPSEVARAVEFGKRREERAEAQELYWAAFARLQQEHPKEASAWDLYHHEDVEDHEECARRLSITVVNSYKRVSRAQAYLKLYLLDLHRESHGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC64</accession>
    <name>Q1DC64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551618.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1507"/>
    <dbReference type="EnsemblBacteria" id="ABF87772">
        <property type="protein sequence ID" value="ABF87772"/>
        <property type="gene ID" value="MXAN_1507"/>
    </dbReference>
    <dbReference type="GeneID" id="41358953"/>
    <dbReference type="KEGG" id="mxa:MXAN_1507"/>
    <dbReference type="eggNOG" id="ENOG5030TKG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828541_0_0_7"/>
    <dbReference type="OMA" id="EVTYAFM"/>
    <dbReference type="OrthoDB" id="1152898at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="36390" checksum="354BB243477D1F4A" modified="2006-07-11" version="1">MDYRKFLGKVESVVLPYLGGGTVDSASRRLRVTTPVTPGWWRFDVKGRDATPREPSEPECLEALPRVRGHAWGRRLVRDGAVAEPLELMPEEEPPRLAPVSARRWFDGALLFEGVDFESEAEGAARLALEQNQPLAHIRGVSAPLRAAFGYALLERVSRDVGIRFAPAEVRGRILAVAEGGRVPAEDCLRRLNHEREAQAARTRQEREDAERRARSAELIEEAQRRMARLATRGVRGNPREDGMQRAQQALVNAGARPLDLRRLAGQRLEVTYAFMGERFVSIVAADSLQVLDAGICLAGADGDVTLESLPSVIREAIETDVLVVTRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB0</accession>
    <name>Q1DCB0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1456"/>
    <dbReference type="EnsemblBacteria" id="ABF92208">
        <property type="protein sequence ID" value="ABF92208"/>
        <property type="gene ID" value="MXAN_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1456"/>
    <dbReference type="eggNOG" id="ENOG5032NIV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804103_0_0_7"/>
    <dbReference type="OMA" id="CGMTHAF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15909" checksum="1996D20A9583933F" modified="2006-07-11" version="1">MRLKVVIPPRNRRFSTVDAMGLAGVVGLLVARYIPVARIIPFWGCVLREQTGWPCLGCGLTRVADRVSHLNFAGAWEANPLGTVAAIVFALAAVVMVLHLVFAMPIPQVELSPREWSVLGVVTPIIILVNYAYVVVKTRFPHLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCD4</accession>
    <name>Q1DCD4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-allo-threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551549.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1432"/>
    <dbReference type="EnsemblBacteria" id="ABF87719">
        <property type="protein sequence ID" value="ABF87719"/>
        <property type="gene ID" value="MXAN_1432"/>
    </dbReference>
    <dbReference type="GeneID" id="41358878"/>
    <dbReference type="KEGG" id="mxa:MXAN_1432"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_7"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="36218" checksum="D854613B39A9AC07" modified="2006-07-11" version="1">MKRIDFRSDTVTQPTAAMRRAIAEAEVGDDVYGEDPTVLRLEARVAERLGLEAAVFVPSGTQANQLAIGAHCRAGDEVLTEAGSHILHYEGGAVPALWGVQPQPLPGQRGLLSPEDVSAAVREDNIHNPRTRLLSLENTHNRGGGSVWPVERFRAVVEAARKAGLAVHLDGARLFNAGVALGVPVSAWAALTDTTSVCFSKGLGAPVGSALAGRADVIREARRLRKRLGGGMRQAGILAAAALHALEHHVERLADDHANARRLAAGLAELPGVEVDASRVETNMVFAEFSRSALEMVARLEQHGVLTNPAGAPRTLRLVTHLDVSAADIDEALQRIRRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD40</accession>
    <name>Q1DD40_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1173"/>
    <dbReference type="EnsemblBacteria" id="ABF89954">
        <property type="protein sequence ID" value="ABF89954"/>
        <property type="gene ID" value="MXAN_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1173"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025323_0_0_7"/>
    <dbReference type="OMA" id="LHTAYWH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="335"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="54480" checksum="2E9497F286F4F2BB" modified="2006-07-11" version="1">MPALTIDPALDDLAQSEEEEDTPGGEELPLPEQLTVIPDELHPGEELVLGPDGEPLEDTGLVLEDVDPGLEPVSGADDGGTYAVPFAPDAGSLRVRRSIVVRQEPRQDAPALGTVAQDMRVRWQGETAVRGPDCEAWIQIEPRGWVCERYLEPNFREPRVRELPKLREGELTPGIYARVVGKRVRAYPSLALARARRKGVLLKGSVSVQLRGQVRIRRRTYWRTTDGQYLEARVLREYRPSSYEGVNAEAIAELPPTFAWAQSRTRPFAAVEVRTAPDAKAARETVLPPRTLVAVKELSEDGHWVSIAEDQWVARDDLHVAWFSHAPPQVEPGSRWLDVDLDAQVLVAYEGERPVYATLISSGKQGTDTPEGLFRIWIKFAEADMTGSGTAGNDTYRVATVPWTMFFQDDYALHTAYWHDRFGQPMSHGCVNLSPKDARALYAWAAPQVPVGWSMVHATEDAPGSWIRIRGQARPTGKPRRVAVAATQGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD54</accession>
    <name>Q1DD54_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, C56 (PfpI) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551279.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1159"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="ABF92442">
        <property type="protein sequence ID" value="ABF92442"/>
        <property type="gene ID" value="MXAN_1159"/>
    </dbReference>
    <dbReference type="GeneID" id="41358610"/>
    <dbReference type="KEGG" id="mxa:MXAN_1159"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_7"/>
    <dbReference type="OMA" id="IGKYGVP"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="223" mass="24024" checksum="031B34FBD629B286" modified="2006-07-11" version="1">MKKLKGLRVAVLAADGFEQVELTAPVKKLERQGADVTIVSPHKGRIRGMNLLIPGKRVSVDASLREVKAADFDAVLLPGGFVNPDLLRQSALALDFVRDADALDMPIAVICHGPWVLISAGLVEGRALAAWPGIRDDVRNAGGRWVDEPVMRDGNWVSSPGPRQMFAFIKGMVELFAEKMPEVSARAPMVPVRQAAPSRWPKLLAGTLATAALGLGARRLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM6</accession>
    <name>Q1DDM6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551107.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0986"/>
    <dbReference type="EnsemblBacteria" id="ABF86294">
        <property type="protein sequence ID" value="ABF86294"/>
        <property type="gene ID" value="MXAN_0986"/>
    </dbReference>
    <dbReference type="GeneID" id="41358442"/>
    <dbReference type="KEGG" id="mxa:MXAN_0986"/>
    <dbReference type="eggNOG" id="ENOG5031DJ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2247123_0_0_7"/>
    <dbReference type="OMA" id="CACCTHA"/>
    <dbReference type="OrthoDB" id="2066461at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="104" mass="11029" checksum="26BAFB0BAE083BA5" modified="2006-07-11" version="1">MLRIWLIVCLFLFAPGLGGLMPTLTGAVGEVCTQSCPDDDDQGQCAPDCIDCTCCAHVRTVAAHAPPLSFVLLVSRPLRVAYEKAEPLSADGRDILHVPIAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDR5</accession>
    <name>Q1DDR5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0947"/>
    <dbReference type="EnsemblBacteria" id="ABF86852">
        <property type="protein sequence ID" value="ABF86852"/>
        <property type="gene ID" value="MXAN_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0947"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004087_0_0_7"/>
    <dbReference type="OMA" id="WLCTTMT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="5">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="31834" checksum="EA14594CE2B2BB5B" modified="2006-07-11" version="1">MKPMSRTPTSTATRPASPRASGSRCRRRRFLPWSGRSIRTPARSADLQARAGFFTLPGIFLSGSFFFFFSRIGPLRVFDWVTRRRACEWGCMSNLFNRDRRRFEAFIRQHRPSLLGLARRLCARSSLEPDDLVQETFERAMPEFEHLKDRTDSAAAAWLCTTMTNRFLDYCRRQRTESRGMPHLALVQDLAVSPEETQENWALVSTDAFQKAIERLKPHLRDAYRLHAEGKRYNAIAEHFNVPVGTVGSWLTLARRDLKELLLPQVAVAREQGATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY9</accession>
    <name>Q1DDY9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate/guanylate cyclase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550994.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0873"/>
    <dbReference type="EnsemblBacteria" id="ABF87098">
        <property type="protein sequence ID" value="ABF87098"/>
        <property type="gene ID" value="MXAN_0873"/>
    </dbReference>
    <dbReference type="GeneID" id="41358332"/>
    <dbReference type="KEGG" id="mxa:MXAN_0873"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346999_0_0_7"/>
    <dbReference type="OMA" id="GEMKNIR"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22200" checksum="09AEBD4C75627EB1" modified="2006-07-11" version="1">MVVEAPEPGKLSAILFTGIEGPDGLSWRDESLQNDMRDEHALLVRELLPRHGGREVKRLEDGFLLEFEGGPSAVDFGLELQRVLDARNGDVSAERRVILRVGVHLGMVVHRDGDVFGEGVNLAARIEALARPGTLYVSETVARQVEGRLASPPVRLGRGEMKNIRLPVAVYRIDPPEHRRRMPLLSRMRSFWGRRSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE34</accession>
    <name>Q1DE34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythromycin esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550949.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0826"/>
    <dbReference type="EnsemblBacteria" id="ABF89534">
        <property type="protein sequence ID" value="ABF89534"/>
        <property type="gene ID" value="MXAN_0826"/>
    </dbReference>
    <dbReference type="GeneID" id="41358291"/>
    <dbReference type="KEGG" id="mxa:MXAN_0826"/>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026490_1_0_7"/>
    <dbReference type="OMA" id="RYGCLTP"/>
    <dbReference type="OrthoDB" id="1068352at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="50038" checksum="928C80C37B2008FD" modified="2006-07-11" version="1">MGSMEEDAPEVSAALLEGIRAAALPVSGRASDLDPLIESIGDARFVLLGEATHGTHEFYQARATLTRRLIAEQGFHALVVEADWPAALRVDAFVRGNGQDATAAGALGNFQRFPRWMWRNREMEELVTWMRAHNATVPPEQRAGFYGMDLYSLHDSMREVVAWLDTVDPDAAQRARERYACFDHFGPEPHVYGQSTTSGQADSCEEQVWAQFVELQRRRTRGPEDADARFHAEQNARLVANAEAYYRAVYAGRHEGWNLRDTHMADTVDALAAHLSRSGPPARLVIWAHNSHLGDARATQMGDQGELNVGQLLRERHGAATYNVGFTTYTGVVIAAHEWDEPGLRRRIQPAMSGSYERLFHDVGMPAFLLRMAELGEAAGGLHERRLERAIGVVYAPRTERWSHYFHANLPAQFDAVLHYDETRALRPLDSDAGHGEEDAPDTYPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE49</accession>
    <name>Q1DE49_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF93010">
        <property type="protein sequence ID" value="ABF93010"/>
        <property type="gene ID" value="MXAN_0811"/>
    </dbReference>
    <dbReference type="GeneID" id="41358277"/>
    <dbReference type="KEGG" id="mxa:MXAN_0811"/>
    <dbReference type="HOGENOM" id="CLU_729225_0_0_7"/>
    <dbReference type="OMA" id="WETMAPA"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="43359" checksum="2C47769F29BD701B" modified="2006-07-11" version="1">MPAPKPKSRLPQDALPVRLESLLEALTDRHLADRLERVHRAAAVAIDRLGHLSIAKYEPTSVEADGGADLSLWETMAPAIGDTLVGVNQLISAVHQEFPPPTRPVGLGDGGWAPPPASSDERLAQEVEAVLHAIADRLARRVAELGQQMRRPEVVSDRWTLMAELQSFRADFRVRIGDLVYLTASAFADVRREEVVPGYAHQLGARAALRAAAADLRRSLQGRLERAAKAEARARPSLARQVAESLSAFVSLPASVALRTPQKHQVLELRARLLDTATQSELAPDALPELVEPYLTTLDEQMEEVTRTWLVVHDRAMWATCGMKLEQADMHLTLGSRGAERVLAEAVEAAGALQGRSAPFDAFLRKARQEAGDGLDEAGARELLGRFRERLAALPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE78</accession>
    <name>Q1DE78_MYXXD</name>
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        <submittedName>
            <fullName evidence="4">SPFH/band 7 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550905.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0779"/>
    <dbReference type="EnsemblBacteria" id="ABF90005">
        <property type="protein sequence ID" value="ABF90005"/>
        <property type="gene ID" value="MXAN_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="41358247"/>
    <dbReference type="KEGG" id="mxa:MXAN_0779"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_7"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="31435" checksum="8E4C4D25DDFFD64F" modified="2006-07-11" version="1">MQLTGLFGVFIPVAILFLLFLSGVRIVNEYQNGVVFRLGRFVGLKRAGFRWLIPFVERMVIIDLRIVARDVPPQDVITRDNVSVKVNAVVYFRVIHADKAVLQVEDYLYATSQLAQTTLRSILGQVELDQLLSERERINHEIQQVLDARTDPWGVKVSNVEVKHIDLPAEMQRAIARQAEAERERRAKIIAAEGEHQAAEKLSMAAKVLGRYPATLQLRYLQTLVEITTGGNHTILPIPLDLLRTLSGVKAHMERADDGHEDRRYTEDEEEGPPAGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA6</accession>
    <name>Q1DEA6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550877.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0751"/>
    <dbReference type="EnsemblBacteria" id="ABF89043">
        <property type="protein sequence ID" value="ABF89043"/>
        <property type="gene ID" value="MXAN_0751"/>
    </dbReference>
    <dbReference type="GeneID" id="41358221"/>
    <dbReference type="KEGG" id="mxa:MXAN_0751"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024917_0_0_7"/>
    <dbReference type="OMA" id="ACDPRDL"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="301"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="598"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="726" mass="79090" checksum="051B6299A11930CA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB3</accession>
    <name>Q1DEB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550870.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0744"/>
    <dbReference type="EnsemblBacteria" id="ABF86426">
        <property type="protein sequence ID" value="ABF86426"/>
        <property type="gene ID" value="MXAN_0744"/>
    </dbReference>
    <dbReference type="GeneID" id="41358215"/>
    <dbReference type="KEGG" id="mxa:MXAN_0744"/>
    <dbReference type="HOGENOM" id="CLU_2684033_0_0_7"/>
    <dbReference type="OMA" id="EPTDAFM"/>
    <dbReference type="OrthoDB" id="1948105at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="74" mass="8253" checksum="09448B0E45B3845D" modified="2006-07-11" version="1">MAITLPDEPIETPFEVPANRPEVTDEPTDAFMKAQVSWDGWAAHGGGHVPEDYAWTSNPKERQDELMGEWPGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF8</accession>
    <name>Q1DEF8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0697"/>
    <dbReference type="EnsemblBacteria" id="ABF91989">
        <property type="protein sequence ID" value="ABF91989"/>
        <property type="gene ID" value="MXAN_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0697"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_5_0_7"/>
    <dbReference type="OMA" id="YELDYDN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="26"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="347" mass="37660" checksum="17F3084B56334466" modified="2006-07-11" version="1">MPTKGKHATRSVPTNAPGNKFRPTTRIGLGGVAIGNGFASTSDAQAQATLEAAWAAGVRYFDTSPWYGLGLSERRFGRFLHTRDANEYVLSTKVGRILTAADAPPPKLLWSDASPFNYQYDYSAAGVRRSVEDSLQRLGVSRIDIVFIHDLSPDNQDMGDKWTEYFDQAIKGAIPELTKMREEGLIKAWGFGVNRAEPALRALEVSDPDIFLLATQYSLTNHEEALSKTFPALEKRGISVVVGSPLDAGYLAGRNRYLYDGTIPPGVQEKRARMSAIAAKHGIDLRTAALQFAAAPSVVSSVIPGARTPEQVKANVQSMTVAIPDAFWEALKKEGLIARDAPIPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEH3</accession>
    <name>Q1DEH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0682</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550812.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0682"/>
    <dbReference type="EnsemblBacteria" id="ABF85961">
        <property type="protein sequence ID" value="ABF85961"/>
        <property type="gene ID" value="MXAN_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="41358157"/>
    <dbReference type="KEGG" id="mxa:MXAN_0682"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_4_3_7"/>
    <dbReference type="OMA" id="WELLHHI"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLH55580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="204" mass="22256" checksum="99A384B80348EDD8" modified="2006-07-11" version="1">MRREHEGAAVRREFFRSAYLLGAPWDIGRPQQAFVQLWEAGAISGEVLDVGCGFAENALFLAAKGLPVCGVDMMEPAILRARETASLRGLDVDLRVGNALELATLGRRFDTILDSALLHVFEPGDRPAFAASLASVLRPGGHYHALYFRDGPRAVPPEALNATFGEGWRVKSIQEAHYEQTDPEGAQAWLATIERVPPSSSTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEI1</accession>
    <name>Q1DEI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0674</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550804.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0674"/>
    <dbReference type="EnsemblBacteria" id="ABF92674">
        <property type="protein sequence ID" value="ABF92674"/>
        <property type="gene ID" value="MXAN_0674"/>
    </dbReference>
    <dbReference type="GeneID" id="41358149"/>
    <dbReference type="KEGG" id="mxa:MXAN_0674"/>
    <dbReference type="eggNOG" id="COG3357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162441_0_0_7"/>
    <dbReference type="OMA" id="CLACGFT"/>
    <dbReference type="OrthoDB" id="1944426at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLH55588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="106" mass="11154" checksum="06E97EC9957F0985" modified="2006-07-11" version="1">MSAPVPPARGSTVRGALEAALTSAPESGLTAKDLSALVGISEKDVAGHLEHLEKSLKVQGARLEVLPASCLACGFTFKDRRRFTRPGACPQCRATRIDPPAFRVIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ2</accession>
    <name>RNZ_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Z</fullName>
            <shortName evidence="1">RNase Z</shortName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnz</name>
        <name type="ordered locus">MXAN_0663</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550794.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DEJ2"/>
    <dbReference type="SMR" id="Q1DEJ2"/>
    <dbReference type="STRING" id="246197.MXAN_0663"/>
    <dbReference type="EnsemblBacteria" id="ABF88454">
        <property type="protein sequence ID" value="ABF88454"/>
        <property type="gene ID" value="MXAN_0663"/>
    </dbReference>
    <dbReference type="GeneID" id="41358138"/>
    <dbReference type="KEGG" id="mxa:MXAN_0663"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_7"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
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            <begin position="1"/>
            <end position="307"/>
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        </location>
    </feature>
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        <location>
            <position position="62"/>
        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
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    <feature type="binding site" evidence="1">
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="1">
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        <ligand>
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        </ligand>
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            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEX6</accession>
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        <submittedName>
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        </submittedName>
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    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
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        <property type="gene ID" value="MXAN_0528"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="354"/>
        </location>
    </feature>
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            <end position="382"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1063" mass="114526" checksum="AD1B4B731E040EF2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ1</accession>
    <name>Q1DFJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="ABF90351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0302"/>
    <dbReference type="EnsemblBacteria" id="ABF90351">
        <property type="protein sequence ID" value="ABF90351"/>
        <property type="gene ID" value="MXAN_0302"/>
    </dbReference>
    <dbReference type="GeneID" id="41357801"/>
    <dbReference type="KEGG" id="mxa:MXAN_0302"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069362_0_0_7"/>
    <dbReference type="OMA" id="TWSLETH"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="28929" checksum="75870729170BFAEF" modified="2006-07-11" version="1">MRYELQDGRILTWSLETHVATHCNLRCVQCCPLSPHLPAWSVDPAALGKDLRQLARALRPNVFKLTGGEPFLHPDLPAVLDAVRASGISPQVSVTTNGFLAQSAPDAVYERLDRMTLSVYTSAPLPERSIARITERCEQHCVFLTVKRIDAFQQLTPAAPHDSEDAVRGIHARCWLKVRCHLVHAGRFYACTRPPHVATVLGGTYPEMPALGEVDGVPLDTPDLLGQMLGYLERETPLATCRYCLGGDGAWQPHAQLPRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK7</accession>
    <name>Q1DFK7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative iron-sulfur cluster binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550430.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0286"/>
    <dbReference type="EnsemblBacteria" id="ABF89509">
        <property type="protein sequence ID" value="ABF89509"/>
        <property type="gene ID" value="MXAN_0286"/>
    </dbReference>
    <dbReference type="GeneID" id="41357786"/>
    <dbReference type="KEGG" id="mxa:MXAN_0286"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="SGCPYCL"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="735" mass="81373" checksum="49825ADFD080CC9A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK8</accession>
    <name>Q1DFK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0285"/>
    <dbReference type="EnsemblBacteria" id="ABF86462">
        <property type="protein sequence ID" value="ABF86462"/>
        <property type="gene ID" value="MXAN_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0285"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1720371_0_0_7"/>
    <dbReference type="OMA" id="WLMPHAR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17494" checksum="5254F884D5CA98F2" modified="2006-07-11" version="1">MLPRGGLTMSLFDAVLAGDRDAVESHLSAGADPNPFDEEGRTPLMAAARAGRADLVQRLLDAGADPELTDSIGESALIMAAAHGHTEVCQWLMPHARADDQDLARTLLSGLGITDLRLDAPPPQDNSFRRKLASAGAYVSGKLGDDGATKRLERVLRSEKQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS5</accession>
    <name>Q1DFS5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0216"/>
    <dbReference type="EnsemblBacteria" id="ABF91731">
        <property type="protein sequence ID" value="ABF91731"/>
        <property type="gene ID" value="MXAN_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0216"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_7"/>
    <dbReference type="OMA" id="FHVNAIC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="424"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="519" mass="56330" checksum="0392408A1F7388A3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX0</accession>
    <name>Q1DFX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550317.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0170"/>
    <dbReference type="EnsemblBacteria" id="ABF90667">
        <property type="protein sequence ID" value="ABF90667"/>
        <property type="gene ID" value="MXAN_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="41357673"/>
    <dbReference type="KEGG" id="mxa:MXAN_0170"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1584720_0_0_7"/>
    <dbReference type="OMA" id="IARYEKG"/>
    <dbReference type="OrthoDB" id="1970743at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022452">
        <property type="entry name" value="MqsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03830">
        <property type="entry name" value="CxxCG_CxxCG_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="19482" checksum="B60A43D374758CBB" modified="2006-07-11" version="1">MKCESCGGELLETRLDSYHFDESGLEDVILVGVIERRCEKCNEREVVIPRLKELHRTIAKALAAKNSLLTPLEVRFLRKHLGFSQADFAKRINVRSEAVSRWETGAEEFSWHFELLLRLMVMLELHERNYTVKSFDEVQEKRLTAPVRIFAEKSAWRPDSTNMLTAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX7</accession>
    <name>Q1DFX7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+-transporting ATPase, F subunit</fullName>
            <ecNumber evidence="2">3.6.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kdpF</name>
        <name evidence="2" type="ORF">MXAN_0163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.12" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0163"/>
    <dbReference type="EnsemblBacteria" id="ABF88567">
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        <property type="gene ID" value="MXAN_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0163"/>
    <dbReference type="HOGENOM" id="CLU_3218984_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09604">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4950" checksum="B180F59AA074273F" modified="2006-07-11" version="1">MGLRPRMRAPVRHCPMTFEYAAGAVLSVLLGAYLIYALLRPARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG59</accession>
    <name>Q1DG59_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">accB</name>
        <name evidence="3" type="ORF">MXAN_0081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
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        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="538" mass="58125" checksum="48E7679421DB3741" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ5</accession>
    <name>Q1CVJ5_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">MXAN_7475</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_7475"/>
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    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="15955" checksum="873137604CCB7098" modified="2006-07-11" version="1">MALLGGKKDESSSKPLFRREEESVSQRSGEVHTLLGKGSEFEGKLTFEGQVRIDGKFQGQIITKDVLVIGDGAKVQAEIQAGTVIINGQVEGNVKATQIIELKTPGRVKGNLETPSLSMDRGVIFEGSLKMENLGTAGARPPPPPGGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVY3</accession>
    <name>Q1CVY3_MYXXD</name>
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        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7327"/>
    <dbReference type="EnsemblBacteria" id="ABF86932">
        <property type="protein sequence ID" value="ABF86932"/>
        <property type="gene ID" value="MXAN_7327"/>
    </dbReference>
    <dbReference type="GeneID" id="41364490"/>
    <dbReference type="KEGG" id="mxa:MXAN_7327"/>
    <dbReference type="HOGENOM" id="CLU_1633611_0_0_7"/>
    <dbReference type="OMA" id="PACQHAL"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="17764" checksum="35CA57C81FE27008" modified="2006-07-11" version="1">MSACRETELDALLADELSPEDATRVRAHAQACPACQHALSWLRAERGWMAQRARRMPARPALDFAALESRLRKPVVPDAPKVNWMHWGKMLTAALASVAFVGITTLQVTRLPSADEPWPRNDALTTATRAVDWCDDPSREAVAALEARVGACLVASPLITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW17</accession>
    <name>Q1CW17_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">MXAN_7293</name>
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    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557212.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7293"/>
    <dbReference type="EnsemblBacteria" id="ABF90067">
        <property type="protein sequence ID" value="ABF90067"/>
        <property type="gene ID" value="MXAN_7293"/>
    </dbReference>
    <dbReference type="GeneID" id="41364456"/>
    <dbReference type="KEGG" id="mxa:MXAN_7293"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_7"/>
    <dbReference type="OMA" id="LFWVYIA"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="29134" checksum="54B1FC83795C2647" modified="2006-07-11" version="1">MKRPGLGTALAVVAFLTFFLGPFCWQVLTSLWPDGELTRPWPSHLTLENYASVLWGRPFLRVVLNSLVVAALTTGFCLTVGAAAAFALAKLEFRGKGVLLSAALAVSMFPPIATVSPLYLILRTVGLRDSLVGLALPYATFALPLTLWVLTSFFRALPDELYRAARVDGCTPFQAFRQVLLPLAAPGLATTAILVFIFAWNEFLYALTFLSTPEKRTVPVAISLFASEYREPWGEIAAASVVATLPLVALTVLFQRRIVSGLTAGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW27</accession>
    <name>Q1CW27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7283"/>
    <dbReference type="EnsemblBacteria" id="ABF92210">
        <property type="protein sequence ID" value="ABF92210"/>
        <property type="gene ID" value="MXAN_7283"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7283"/>
    <dbReference type="eggNOG" id="COG1367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141603_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="25700" checksum="DD0B03B948C4CABE" modified="2006-07-11" version="1">MRPRGGDVLERADDEESSAAATGATLPDPAPRQRRSVRGPDLTRFSVSLRTVTHSLDGAATLRQVDVVEPVRVPALRGQLRFCWRALNTHACASPMELASRERALWGGTGGGVAICSKVEFGGGICAVACTSHQDRLSAKAPSPMLERWVVLHASCRRSIGMAHCIRERGSCLEHLGRPRGAHTPLAGKSDADLSAVLPRTVVDGSVNHLVAGIGTPGPQSRLALSSQSFLLLKGRHVLSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWL8</accession>
    <name>Q1CWL8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557011.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86836">
        <property type="protein sequence ID" value="ABF86836"/>
        <property type="gene ID" value="MXAN_7092"/>
    </dbReference>
    <dbReference type="GeneID" id="41364267"/>
    <dbReference type="KEGG" id="mxa:MXAN_7092"/>
    <dbReference type="HOGENOM" id="CLU_1569745_0_0_7"/>
    <dbReference type="OMA" id="RRPQSWC"/>
    <dbReference type="OrthoDB" id="1551000at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="18000" checksum="EB771F423668838E" modified="2006-07-11" version="1">MSDRPGMSALVSHSTTNSSSTRVLEQRNLLGGMDLLPVLGGKGRKRARRFHVASERRVGFAAALALVVEHGKQKAKETGVTSLSRCPRCGHMGPTAQDFGYRTMRGERRPQSWCRGCRGLHLEPTETARTSNTAPRGADGWLFPPESTTSTRPPRRGKGSSTQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWN8</accession>
    <name>Q1CWN8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, GntR family/aminotransferase, classes I and II family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556991.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7072"/>
    <dbReference type="EnsemblBacteria" id="ABF92343">
        <property type="protein sequence ID" value="ABF92343"/>
        <property type="gene ID" value="MXAN_7072"/>
    </dbReference>
    <dbReference type="GeneID" id="41364247"/>
    <dbReference type="KEGG" id="mxa:MXAN_7072"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_7"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="486" mass="53231" checksum="D518540E5E2B166C" modified="2006-07-11" version="1">MRLTLGGAMGAVAHKAKLYEQVAERLADAISAGTLQPGDRLPSVRQLSLRERVSISTVLQAYLHLESLGLIETRPQSGHYVRRRERPRLAEPQVSRPASSATAVTVSGLVASVYRSMGDARMVKLGAASPAPELLPVRRLYRELNALSRESRDRSIQYDALPGCPELRQQLARRSMDWGCSLAADDFITTFGASEAIHLCLLAVARPGDTIAIESPAYYGTLQSIEALGLRALEIPCCPRNGMQMEALEAALTRRRIAAVLAVPSFSNPVGSCMPDVRRQRLVNLLDAHDVPLIEDDIYGDLHFGAERPRSCKAFDTRGNVLLCSSFSKTLAPGFRVGYVAPGRFRERVELLKFSTSVTTATVPQYAIARFLQNGGYDRHLRSLRRRLAAQVERMAEAVAEFFPEGTRVTRPSGGALLWVELPRQVDSLALSAKALEAGISIAPGPIFSARMDSYRHCFRLNCGHPWTPRIEAAMSTLGALARSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWW3</accession>
    <name>Q1CWW3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TonB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_6997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6997"/>
    <dbReference type="EnsemblBacteria" id="ABF86330">
        <property type="protein sequence ID" value="ABF86330"/>
        <property type="gene ID" value="MXAN_6997"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6997"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016599_1_0_7"/>
    <dbReference type="OMA" id="TDLWVPV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TonB_C" evidence="10">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="925" mass="100495" checksum="A16A5E6C6C0ECCA0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX15</accession>
    <name>Q1CX15_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87553">
        <property type="protein sequence ID" value="ABF87553"/>
        <property type="gene ID" value="MXAN_6943"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6943"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_0_7"/>
    <dbReference type="OMA" id="DEQLGMM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13868" checksum="7E458C1A11E35B43" modified="2006-07-11" version="1">MRYVLPRMDEQLGMMVGKAAREARARLGLTQVEVAALVDMHPMVYSRVERGKMVPSAGMLRRLSMVLRISTDELLGLARPGKDERRELEKEPPLLRRLVTLARELDDVKLEALVTMARALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA2</accession>
    <name>Q1CXA2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556779.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6854"/>
    <dbReference type="ESTHER" id="myxxa-Q84FB1">
        <property type="family name" value="ABHD18"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90609">
        <property type="protein sequence ID" value="ABF90609"/>
        <property type="gene ID" value="MXAN_6854"/>
    </dbReference>
    <dbReference type="GeneID" id="41364043"/>
    <dbReference type="KEGG" id="mxa:MXAN_6854"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035640_1_1_7"/>
    <dbReference type="OMA" id="WLPAGHV"/>
    <dbReference type="OrthoDB" id="969996at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PTHR13617"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="DUF2048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="35659" checksum="79101C5BD29FECA2" modified="2006-07-11" version="1">MARVLRTHPVDVLFAGLSRRARLFSQGWGDEQFLEEVAAAAPFQQRPPPIAPEWSAPRLQRGLQVRDGTFPSPLARLDAAARTAHVRWLSAGQGPSRGACVVLAASREEGFSLRERMYAPLAREGIDLFLLENPYYGLRRPVGQKGGALRTVSDHVLMNLGMVDEARALLAWLRSEGHARLGVAGYSMGGYMAALTAAVVPEPLAVAALAAGASPVPVFTQGLLSWSIAFALLDGPRRDAEQARSRLGRIFDLANLARFPPPRQPEAAVLVACRRDGFVPGDETLALHAHWPRSELRWVDAGHVTALFTERAALCAAIRDALSRVEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXG1</accession>
    <name>Q1CXG1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0187 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556720.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6795"/>
    <dbReference type="EnsemblBacteria" id="ABF86481">
        <property type="protein sequence ID" value="ABF86481"/>
        <property type="gene ID" value="MXAN_6795"/>
    </dbReference>
    <dbReference type="GeneID" id="41363985"/>
    <dbReference type="KEGG" id="mxa:MXAN_6795"/>
    <dbReference type="eggNOG" id="COG3781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029790_4_2_7"/>
    <dbReference type="OMA" id="TDICGAC"/>
    <dbReference type="OrthoDB" id="1348684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin/UPF0187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="UPF0187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="PTHR33281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="34702" checksum="932CC9B13B31E22D" modified="2006-07-11" version="1">MIVRPRLSSLRLLFVVRGTILPRVLPHVLGIAALSALVVWAYRQGYLDLQISSPAPLSLLGIALSIFLGFRNNACYDRWWEARKHWGALIIELRSFSHEAIALLGDDSSGAKEAARRLARRNIAFAHAMVAHLRGNDAREDISRLLPEPEASRVLASQNRPNALLREHDRELATLLREKHLTDITWSELRTHVHGLMNVLSACERIRFTPLPFTYTVLLHRTAYLFCLLLPFGLAEALGWFTPWLAAMIAYTFFGLDRLSDELEEPFGTEPNDLSLLAMARSVEMNLMEALGEPQPEPLKPRDFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXH3</accession>
    <name>Q1CXH3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decarboxylase, group II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556708.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6783"/>
    <dbReference type="EnsemblBacteria" id="ABF91644">
        <property type="protein sequence ID" value="ABF91644"/>
        <property type="gene ID" value="MXAN_6783"/>
    </dbReference>
    <dbReference type="GeneID" id="41363973"/>
    <dbReference type="KEGG" id="mxa:MXAN_6783"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_7"/>
    <dbReference type="OMA" id="NPGFNWS"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="480" mass="52011" checksum="E48E9A5A3A69314A" modified="2006-07-11" version="1">MTDFQARIAAAYDADAFRRESHRLMDTLSDYLARATRAEGPVLPWAAPAVNVDRFAAAFPEAPTGDFADLITRVLSGSNHLHHPRYVGHQVTAPVPLAALCDAVSSLLNNGMAVYEMGPVSTAMERNVLRWMAARLGLPETTDGVLTSGGSLGNLTALLAARQAKAGYDAWNGGAHAGPPLTVLTAQTTHYSLARATRVMGFGEGGVTPVPVDEHFRLRPEALDAALESATRAGRKPIAVVANAGSTATGAFDPLEPVADFCERHDLWFHVDGAHGASAVLSPAHRHLVRGIDRADSVVWDAHKGLLMPALVTAVLFRDGARSFESFSQEASYIFHGDAERPWSDVALRTLECTKEMMALKVYACLAVLGTRLFSDAVTESYEQAHRFAQRLSAASDFEVAVPPECNILCFRHTPAHVPAEQWDTLQTKLRERLVTRGDFYLVQTKLPRGVYLRVTLINPLTTDADLDALMDALRAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL3</accession>
    <name>Q1CXL3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxo acid dehydrogenases acyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556668.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6743"/>
    <dbReference type="EnsemblBacteria" id="ABF92058">
        <property type="protein sequence ID" value="ABF92058"/>
        <property type="gene ID" value="MXAN_6743"/>
    </dbReference>
    <dbReference type="GeneID" id="41363935"/>
    <dbReference type="KEGG" id="mxa:MXAN_6743"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078657_0_0_7"/>
    <dbReference type="OMA" id="CTWDARL"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="2">
        <location>
            <begin position="80"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid_dh" evidence="2">
        <location>
            <begin position="239"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="36261" checksum="702A01E12E8B42B9" modified="2006-07-11" version="1">MEGERQGQGDGRHVGASGGGKPLSNRAAGQAQGSAQGHSCRGPGSVRRRKLPVHLDLQPAPPAGAFRKLALGTWRSPGDPSAYAAVEVRMERAVAFLEAFRARTGQRLTVTHLVAKAAADALRRHPEVNVLMRWNRPWRRKEVGVCVLVVQPSETGRADLTTATVHRADSLSLGAFAETMASRIAAVRARRDAVIERGKRRSSLIPGFLMGLALRMLSFVWFTLNVDLRWVGMPWDPFGSVAVTSLGSLGLERGYVALVPYTRVPFLLAPGAVRTEPVVDAGALVPGQVMTLTCTWDARLIGVEDAARVLRDIGAALEDPEGTWGSASPEGGGAASGAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXT8</accession>
    <name>Q1CXT8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556593.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6668"/>
    <dbReference type="EnsemblBacteria" id="ABF92038">
        <property type="protein sequence ID" value="ABF92038"/>
        <property type="gene ID" value="MXAN_6668"/>
    </dbReference>
    <dbReference type="GeneID" id="41363866"/>
    <dbReference type="KEGG" id="mxa:MXAN_6668"/>
    <dbReference type="eggNOG" id="COG3861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076580_0_0_7"/>
    <dbReference type="OMA" id="TGERAMS"/>
    <dbReference type="OrthoDB" id="1255134at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02271">
        <property type="entry name" value="TIGR02271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2382" evidence="2">
        <location>
            <begin position="182"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="315" mass="34507" checksum="AC8776888E30267F" modified="2006-07-11" version="1">MASRSARPGHEEPAMYQRSDVNEGMVVRSIDGEKLGKVFAIGDGEFHIEKGLFFPKDYLVRYSEISRIDGSEIILSHGKEMLSRLTGEDRTGAVAGTGGGAGVGPGAVGLGADQAAARASTGMDATTDTVGRKGTYDTGYDTRLGADARHGTGVDTDTAGLKATDTTVGARDIHGREEDITIPLHKEEVDVLKRDVQAGEVRVHKDVVEEDREMDVPVRRERVRVERRDVSPGRPAMNASFQEETVVVPLRAEEVEVQKRAVVDEEVVIHKDEVDEERHISEHVRREEVDIRTEGSDERARTLNAPSDDPLKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ8</accession>
    <name>Q1CXZ8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">agmT</name>
        <name evidence="7" type="synonym">mltG</name>
        <name evidence="8" type="ORF">MXAN_6607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556533.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6607"/>
    <dbReference type="EnsemblBacteria" id="ABF91362">
        <property type="protein sequence ID" value="ABF91362"/>
        <property type="gene ID" value="MXAN_6607"/>
    </dbReference>
    <dbReference type="GeneID" id="41363805"/>
    <dbReference type="KEGG" id="mxa:MXAN_6607"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_7"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="339" mass="37749" checksum="2CD69DF7B21578BD" modified="2006-07-11" version="1">MKRILWVLGAAFVLLVASGAGAFFWIEQQARTAAAPPGADVVEFTVPKGTSGRGLGTLLESQGLIRDARVWRWHLYRRGSFAPKAGRHEVSASMTLAELATELEGNPIPEDVPFVVVEGWRLRDTDAALVAAGFIKPGAYIAAASKPKNFTAPFPLPSTGTLEGYLYPETYGVIPGKFDVEALIQRQLDAFAQRFFAPNRDTITKSGRTLHEVVVMASMLEREEPLPDQRPLVAGILWKRVDKGFPLGVDATSRYELAQWNDRVAFLKRLRDPQDPYNTRHKKGLPPGPIGAPTVSSLQAAMLPKPSEYWYYLHDAQRILRPSRNAEEHEALRRKYNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY10</accession>
    <name>Q1CY10_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556521.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6592"/>
    <dbReference type="EnsemblBacteria" id="ABF88417">
        <property type="protein sequence ID" value="ABF88417"/>
        <property type="gene ID" value="MXAN_6592"/>
    </dbReference>
    <dbReference type="GeneID" id="41363794"/>
    <dbReference type="KEGG" id="mxa:MXAN_6592"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102087_0_0_7"/>
    <dbReference type="OMA" id="FMRLLWA"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="20467" checksum="582EFAE6B304DDB3" modified="2006-07-11" version="1">MTAEESPKGPAEDPLGPHEGERTYKGPPLGEVLEFMRLLWAVDHGLQSTSKRMESTLGLTGPQRLVIRLVGRFPDITAGMLAQILHVHPSTLTGVLKRLEKRGLLERKSDPLDGRKALFSLTDEGRALDIPSEGTVESSVQRVLSRLSRSNIVATQEVLTALARELGGVPMPEVEYDEAGARKQVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY70</accession>
    <name>Q1CY70_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphocarrier protein HPR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptsH</name>
        <name evidence="5" type="ORF">MXAN_6531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6531"/>
    <dbReference type="EnsemblBacteria" id="ABF92569">
        <property type="protein sequence ID" value="ABF92569"/>
        <property type="gene ID" value="MXAN_6531"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6531"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_1_1_7"/>
    <dbReference type="OMA" id="SIMAMMM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10066" checksum="9B9277403C495DAB" modified="2006-07-11" version="1">MGVAMASVVEGTYEIINALGLHARAAAQMVKVANRFKSEVTIEAQGQRANAKSIMGVLMLAAAQGTQVKLTCKGDDADACLQELAKLIGDRFGEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY97</accession>
    <name>Q1CY97_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alginate biosynthesis protein AlgI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">algI</name>
        <name evidence="11" type="ORF">MXAN_6503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556434.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6503"/>
    <dbReference type="EnsemblBacteria" id="ABF89933">
        <property type="protein sequence ID" value="ABF89933"/>
        <property type="gene ID" value="MXAN_6503"/>
    </dbReference>
    <dbReference type="GeneID" id="41363711"/>
    <dbReference type="KEGG" id="mxa:MXAN_6503"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_3_7"/>
    <dbReference type="OMA" id="IIWGAWH"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="471" mass="52465" checksum="44E9147A96A3CA58" modified="2006-07-11" version="1">MLSHSVQYLVFVIAVFALYWAVHRHYWPRIGVLLVASLFFYAAFTPFPILIFLVGVTVDHLCVKGMARAQSQGVRKALVTVSVVSNLSLLAGFKYLEMLRQSLLSLLAPWGIEVRAEPFNLLMPVGLSFFVFQAISYTVDVYRQKASAEHSFIEHLLYLLFFPRVVSGPIVRASELMVHFRQTPSLTPEAGGHALFRIAVGLVKKLVIADVLGAGLVDPVFAAPEKYASAECIVAAVAYTFELYYDFSGYSDIAIGVAALFGFKFPENFNRPYLAKNIGEFWNRWHLSLSTWLRDYLYRPLGGNRVSKPRVLFNLMTVMVLGGLWHGADWRFAVWGAVHGVALCVSRCWEWSVGKPESPGIPRVALGMLTTFTIVVLTRVVFRAADMAHAGEFYERMMAGVPGIANVSPLVWGMLAAAVFFHAVPMKLYTVSSDLFVRMPVPVRAAVLVVLGLGIRHLSAVEARPYVYLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM9</accession>
    <name>Q1CYM9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase SLT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556302.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6370"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87921">
        <property type="protein sequence ID" value="ABF87921"/>
        <property type="gene ID" value="MXAN_6370"/>
    </dbReference>
    <dbReference type="GeneID" id="41363583"/>
    <dbReference type="KEGG" id="mxa:MXAN_6370"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064715_0_0_7"/>
    <dbReference type="OMA" id="NGETEFY"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="80"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="25892" checksum="8E2270FA30D98619" modified="2006-07-11" version="1">MGRKRAARRGGMTVPGWAWWLPCVLAPVVLLNVAVAWFGNSFVSPLSFSFLEAKAGALRAYLAHRPSCLVEGHAPLEPVIDAAERRHRLPPGLLRALVQVESETRVHRISPAGAMGPGQLMPGTAAMLGVKDPFDPEPAIDGSARYLAQQLRRFGDVRLAVAAYNAGPGSVNGRVPRNGETEFYVPKVLAAWELTRPPPPRKAPPAVKPVAKPKPVAPARTKAPASAAKEPKKPAAPAENGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYX8</accession>
    <name>Q1CYX8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative 2',3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6266"/>
    <dbReference type="EnsemblBacteria" id="ABF86869">
        <property type="protein sequence ID" value="ABF86869"/>
        <property type="gene ID" value="MXAN_6266"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6266"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_4_3_7"/>
    <dbReference type="OMA" id="NAQLWYA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
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        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="9">
        <location>
            <begin position="363"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="602" mass="65268" checksum="1CD06FE10AA645AB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ17</accession>
    <name>Q1CZ17_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556169.1">
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6225"/>
    <dbReference type="EnsemblBacteria" id="ABF86097">
        <property type="protein sequence ID" value="ABF86097"/>
        <property type="gene ID" value="MXAN_6225"/>
    </dbReference>
    <dbReference type="GeneID" id="41363451"/>
    <dbReference type="KEGG" id="mxa:MXAN_6225"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035802_0_0_7"/>
    <dbReference type="OMA" id="RTTYRWS"/>
    <dbReference type="OrthoDB" id="760731at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="370" mass="40395" checksum="EA4DC2BFB01D94C8" modified="2006-07-11" version="1">MRQQDARNAAPKPVGWKVSGGPMSPPRASALLLTIVVSAGGCTKTPTEEVRKEANGSIQCQTLQHLACTGLYGEGGTGWATRAIPPEVRPYEPGLQLWSDGLDKTRFIYLPPGTKVDTSKSDEWRFPVGTKLWKEFSWKGRPIETRFLWKRPDGSWLRTTYRWSDDGKTALELTSGEKDVPGTEGYEIPSQQDCQSCHRGRGDEVLGFEAVALAHDGARGLTLAKLVEEGHLSHPPAQVPRIPGTPVEQAALGYLHMNCGVSCHSANRMALGNSSGLHLRLEAGELGSVQETDTWRTSVNVKALIQTSGMFGKSSQRVAPGDVQHSSLLYRMGQRGDFMQMPPLGTLVVDEQGRALIQRWIEAMPVKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ47</accession>
    <name>Q1CZ47_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556139.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6195"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92721">
        <property type="protein sequence ID" value="ABF92721"/>
        <property type="gene ID" value="MXAN_6195"/>
    </dbReference>
    <dbReference type="GeneID" id="41363424"/>
    <dbReference type="KEGG" id="mxa:MXAN_6195"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_7"/>
    <dbReference type="OMA" id="AWMAREV"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023881">
        <property type="entry name" value="Thiol_BshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03999">
        <property type="entry name" value="thiol_BshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="203"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="42939" checksum="F4557F077B0206DA" modified="2006-07-11" version="1">MNAPLNVAITCFPTFGGSGMVATEIGLAMADRGHRVHFIARDLPVRLHGANRKVVFHEVTESDYPALQQSGTYPIALASKMIEVASYERLDILHVHYAVPHATAAWMAREVLGHKAPRVVTTLHGTDTTLVGIDPSYLPITRFSITRSDAVTVPSAYLRRATWRGFDIPESVPIDVIANFVDTARYAPVRDRACLRALFPALRDHEPVLIHVSNFRPVKRITDVVAIFTEVHRHRPCRLVMVGDGPERSPAERMLREMGLEGRVAFLGKQDRFEELVAASDVFLLPSEQESFGLAALEALSCGIPVVASDLGGIPELVTHGETGFLAPLGDVPAMARHVLTLVEDAERWQGFSHRARAQVLERFQKEPAIDRYEALYRRLLTGPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA7</accession>
    <name>Q1CZA7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86710">
        <property type="protein sequence ID" value="ABF86710"/>
        <property type="gene ID" value="MXAN_6133"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6133"/>
    <dbReference type="HOGENOM" id="CLU_3292843_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="40" mass="4397" checksum="FC557525D6D42325" modified="2006-07-11" version="1">MAPTKNAWPHDAFEDADAAEARGVELERLNPGSRFAVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C9</accession>
    <name>Q1D0C9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5757"/>
    <dbReference type="EnsemblBacteria" id="ABF86261">
        <property type="protein sequence ID" value="ABF86261"/>
        <property type="gene ID" value="MXAN_5757"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5757"/>
    <dbReference type="HOGENOM" id="CLU_1473702_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187762" evidence="1">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19499" checksum="79034A59E007191A" modified="2006-07-11" version="1">MRHMSMKSCCAVLVAALFLGACVATKPSVTYSSFGEARLAEDAAVVQRYEADYERRHPSSTSMTGNQFQIPVASGSSDVKVLVDTFPEGVELVNGSIRTTDGAPHEILGKLSLRASSHGTLPREKLLEEAKQLARAAGGNVVIMSFVGGDQAEANGVVGYVLKSDLEHYNPKKSQSGKLSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0H6</accession>
    <name>Q1D0H6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555661.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91072">
        <property type="protein sequence ID" value="ABF91072"/>
        <property type="gene ID" value="MXAN_5709"/>
    </dbReference>
    <dbReference type="GeneID" id="41362954"/>
    <dbReference type="KEGG" id="mxa:MXAN_5709"/>
    <dbReference type="eggNOG" id="ENOG5031FGR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061012_0_0_7"/>
    <dbReference type="OMA" id="AWWATWI"/>
    <dbReference type="OrthoDB" id="1706087at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025565">
        <property type="entry name" value="DUF4328"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14219">
        <property type="entry name" value="DUF4328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="28187" checksum="1537557DF6849A05" modified="2006-07-11" version="1">MLTESAVPETAPVCPDHAGEPSTGTCERCGRFVCAKCRTAQAGVCAACSARQVQALPHTRGRTRWASVALAASAVLAIPVAILNLWLYLRFDNGSPSLEDAESFDQLNALLALPSLLTMLATVVLYLRWLRLSVKTANALGLSNESTGWATFCWFIPFANLFKPLEVVRDLWQGLGGPPERQSMLTAWWATWILSNIISNVGNAFARADTANPTSLSVSLLAGILSEGLSIAAAVLCIRVIGDIESLLVARRAEAEATMTGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V9</accession>
    <name>Q1D0V9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555529.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5575"/>
    <dbReference type="EnsemblBacteria" id="ABF92136">
        <property type="protein sequence ID" value="ABF92136"/>
        <property type="gene ID" value="MXAN_5575"/>
    </dbReference>
    <dbReference type="GeneID" id="41362822"/>
    <dbReference type="KEGG" id="mxa:MXAN_5575"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567209_0_0_7"/>
    <dbReference type="OMA" id="ATDGYKF"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="53221" checksum="AB13A100A8588E78" modified="2006-07-11" version="1">MSTSLLATDGYKFSMAEAGWPLRRETFYYSHRRGGLQVMPLDVAAFVKSLIPEPKPEDYDYLSRYDYEMGVGFKAAILRREKLSIRAIPKGALFYPREPILTLTGPSALVSWVEPLLLQLNFRIQVATLALSDRDALARALATVTCDEQKAIALETLDSVGVKAVPITVDTEGYAKRVFATVKELVDIVEDPSRIFEVGLRAATCLEQHEVALRSCKDAGVTRTSNVDGAAKLGMVPVGTMGHEHIQRYGSDEAAFRAMRERRPQRSSYLLDTFDTLTSGIPAAFQLIQEEPGNNDSIRFDSGNKKLQYLYAVTRARDLGIRPVNILEDGLDAEATREFEELRRQVGWEPSAQFYGYGGHIIARTMDCPLTRDKVAAIYKLSRTGNTPVMKFGNELAEGKKSIPGEPVLFRRRHGSGPIGLVGQVGEPVPDGYFPLMESAPETPSLVGAQETAAEARVAYTAATQALVDALHRRHFPQQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D112</accession>
    <name>Q1D112_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555476.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87819">
        <property type="protein sequence ID" value="ABF87819"/>
        <property type="gene ID" value="MXAN_5518"/>
    </dbReference>
    <dbReference type="GeneID" id="41362771"/>
    <dbReference type="KEGG" id="mxa:MXAN_5518"/>
    <dbReference type="HOGENOM" id="CLU_157920_0_0_7"/>
    <dbReference type="OMA" id="RQARGWI"/>
    <dbReference type="OrthoDB" id="1783231at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="14283" checksum="C640AC97D307C310" modified="2006-07-11" version="1">MTSWQQEVHAMPVCRPPVSPGFSATRHFVERSSLRQLRDDVLDFILEFGIRTRAAGMTHVTVLERELPWAWRSLDVARQARGWIVLLNDEERLITCYRRGDANRFIRRKPKHRMSGVQLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1A9</accession>
    <name>Q1D1A9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase, S8A (Subtilisin) subfamily</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89266">
        <property type="protein sequence ID" value="ABF89266"/>
        <property type="gene ID" value="MXAN_5417"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5417"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_5_0_7"/>
    <dbReference type="OMA" id="YSISWNT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188008" evidence="6">
        <location>
            <begin position="21"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="150"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="663" mass="69881" checksum="FFFF502EE4B5CF86" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F1</accession>
    <name>Q1D1F1_MYXXD</name>
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        <submittedName>
            <fullName evidence="7">Fatty oxidation complex, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5372"/>
    <dbReference type="EnsemblBacteria" id="ABF89940">
        <property type="protein sequence ID" value="ABF89940"/>
        <property type="gene ID" value="MXAN_5372"/>
    </dbReference>
    <dbReference type="GeneID" id="41362640"/>
    <dbReference type="KEGG" id="mxa:MXAN_5372"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_0_7"/>
    <dbReference type="OMA" id="DIYEIHE"/>
    <dbReference type="OrthoDB" id="330994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="294"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="433" mass="45774" checksum="84E8B94AAF70FC5E" modified="2006-07-11" version="1">MASEKRNGPRRVAIVRGLRTPFVKAGSVFSGLTALDLGRLVVQELVQKTDLDPNVIDQVVFGQVIPTLTAPSIAREVVIAAGLPKKIDAFTVSRACATSIQALTTAANAIATGEADVIIAGGTESMSDAPIFTSRPLAHALVAASKGRSLPDKLKPFQRLKAKDLLPVPPAIAEYSTGMTMGESAEKMAKENGISREEQDRIAFNSHRNAAKAWKDGLFDNEVMHVVVPPKFDKTAERDNIVREDSSMEALGQLKPAFDRKYGTITAGNASPLTDGAAALLLMSEEKARALGYEPLGFLRSHAYAATDPGDQLLQGPAYAVPTALKRAGMTLADIDLVEMHEAFAAQVASNIQALASQAFAKKAGWSAPVGEIDRERLNVTGGSIAIGHPFGATGARIVTQAINELKRRNKNTAMCTVCAAGGLGAVVILERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F8</accession>
    <name>Q1D1F8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hsfB</name>
        <name evidence="8" type="ORF">MXAN_5365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555330.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D1F8"/>
    <dbReference type="STRING" id="246197.MXAN_5365"/>
    <dbReference type="EnsemblBacteria" id="ABF92155">
        <property type="protein sequence ID" value="ABF92155"/>
        <property type="gene ID" value="MXAN_5365"/>
    </dbReference>
    <dbReference type="GeneID" id="41362633"/>
    <dbReference type="KEGG" id="mxa:MXAN_5365"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="HELNSPM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="309"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="527" mass="58484" checksum="B190DF994930A4BA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H2</accession>
    <name>Q1D1H2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2/helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555316.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5351"/>
    <dbReference type="EnsemblBacteria" id="ABF92939">
        <property type="protein sequence ID" value="ABF92939"/>
        <property type="gene ID" value="MXAN_5351"/>
    </dbReference>
    <dbReference type="GeneID" id="41362620"/>
    <dbReference type="KEGG" id="mxa:MXAN_5351"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_0_7"/>
    <dbReference type="OMA" id="VAWCEME"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00271">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="631"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="915"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121358" checksum="A7A72DADB4A51AC6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D242</accession>
    <name>Q1D242_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic amino acid hydroxylase, biopterin-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5127"/>
    <dbReference type="EnsemblBacteria" id="ABF87052">
        <property type="protein sequence ID" value="ABF87052"/>
        <property type="gene ID" value="MXAN_5127"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5127"/>
    <dbReference type="eggNOG" id="COG3186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034458_0_0_7"/>
    <dbReference type="OMA" id="IRTHEHI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016714">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="525" mass="57213" checksum="1C679A152CE0B0DE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F6</accession>
    <name>Q1D2F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Group II decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5012"/>
    <dbReference type="EnsemblBacteria" id="ABF91175">
        <property type="protein sequence ID" value="ABF91175"/>
        <property type="gene ID" value="MXAN_5012"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5012"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005446_1_0_7"/>
    <dbReference type="OMA" id="ANYEGLW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="722" mass="80450" checksum="7A311EBFE103B209" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L6</accession>
    <name>Q1D2L6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ICE-like protease (Caspase) p20 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554929.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4951"/>
    <dbReference type="EnsemblBacteria" id="ABF90204">
        <property type="protein sequence ID" value="ABF90204"/>
        <property type="gene ID" value="MXAN_4951"/>
    </dbReference>
    <dbReference type="GeneID" id="41362236"/>
    <dbReference type="KEGG" id="mxa:MXAN_4951"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496803_0_0_7"/>
    <dbReference type="OMA" id="PYLWRWE"/>
    <dbReference type="OrthoDB" id="177353at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187825" evidence="1">
        <location>
            <begin position="22"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="548" mass="60111" checksum="DC3B1BB027B88664" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M1</accession>
    <name>Q1D2M1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554924.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4946"/>
    <dbReference type="EnsemblBacteria" id="ABF85945">
        <property type="protein sequence ID" value="ABF85945"/>
        <property type="gene ID" value="MXAN_4946"/>
    </dbReference>
    <dbReference type="GeneID" id="41362231"/>
    <dbReference type="KEGG" id="mxa:MXAN_4946"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160040_0_0_7"/>
    <dbReference type="OMA" id="RMGMFAN"/>
    <dbReference type="OrthoDB" id="2084822at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF85945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="82" mass="8440" checksum="32C215F4F00A1424" modified="2006-07-11" version="1">MGICTWLVLGGIAGWLASIIKGTNARMGMFANIATGIVGAMIGGWIFSLMGGTGVTGFNLWSLLVATVGSVILITIVQAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2T0</accession>
    <name>Q1D2T0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554868.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4886"/>
    <dbReference type="EnsemblBacteria" id="ABF91661">
        <property type="protein sequence ID" value="ABF91661"/>
        <property type="gene ID" value="MXAN_4886"/>
    </dbReference>
    <dbReference type="GeneID" id="41362176"/>
    <dbReference type="KEGG" id="mxa:MXAN_4886"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2047162_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188176" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="120" mass="12773" checksum="677BE0884296131F" modified="2006-07-11" version="1">MSRLPGLTRALARVLALTASAADADTLRRFALVAGDDQGGADTRPLRFARDDAGKMHALLLRLGDTRLGFDDLKRWLAEPSSSIRIAILDSCRAGAMTRTKGARRAPDGRGMAVLDVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2W5</accession>
    <name>Q1D2W5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M15_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4847"/>
    <dbReference type="EnsemblBacteria" id="ABF91505">
        <property type="protein sequence ID" value="ABF91505"/>
        <property type="gene ID" value="MXAN_4847"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4847"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509704_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="22738" checksum="C4552262E1DEE6B9" modified="2006-07-11" version="1">MARRVRRRPSRPGPADRGAGASPHVPVGRAGLVMTHANFERVDLDLVYPSFVVVALEVIARCAARGVRYVATHGFRDLTEQAELRRLYLAGKGGKAAPAGLSAHNYGLAFDFVCDASPQPGVQPDWCESAYLVLGEESAKAGLVWGGRFGDSPHVQWPGYVSALQLTPLRTLVQQSSLAGVWARLNAERLSPKWRAANPKLAAELERLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D389</accession>
    <name>Q1D389_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554709.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4722"/>
    <dbReference type="EnsemblBacteria" id="ABF91546">
        <property type="protein sequence ID" value="ABF91546"/>
        <property type="gene ID" value="MXAN_4722"/>
    </dbReference>
    <dbReference type="GeneID" id="41362021"/>
    <dbReference type="KEGG" id="mxa:MXAN_4722"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813350_0_0_7"/>
    <dbReference type="OMA" id="WQVDIPH"/>
    <dbReference type="OrthoDB" id="703715at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="248"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="386" mass="42274" checksum="6467D18241B17945" modified="2006-07-11" version="1">MNTVAPPTSPTGSVSLHATSSYPRGAVHPHVPRLVAARDTRGLHRAMNARLLLLAFVLSSPMPVLADAVRVSLEGRAVLGEKLPALLVHIEEPIAGFEVKLKRSDGQDVEVKGGGSPGLTRRIELNQPEGRFRYEGALTVRFPDAESGVMPLSFDTELYGTLKLDVRKEDVDVAARRLRFVLSRPAKRAELTVLMDTGKKAFEGEVPFKGEAGGTPLELTWPAAEGRVMKISLRAFDTAEFYTGVDLYPWQVDIPHEEVNFASGQADIPATERGKLDKSHALIVDALTKYGRFASLRLYVMGHTDTVGAAAENLDLSVRRAKSLAAYFRKKGLRVPVYYEGLGEEAPAVATPDETAEAGNRRAEYIIAVEEPVLQHAPRPPRWRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3A2</accession>
    <name>Q1D3A2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-beta-D-heptose 1-phosphate adenosyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554696.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4709"/>
    <dbReference type="EnsemblBacteria" id="ABF88778">
        <property type="protein sequence ID" value="ABF88778"/>
        <property type="gene ID" value="MXAN_4709"/>
    </dbReference>
    <dbReference type="GeneID" id="41362008"/>
    <dbReference type="KEGG" id="mxa:MXAN_4709"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_0_7"/>
    <dbReference type="OMA" id="KGTDYTP"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="17580" checksum="FF853586E5F4979F" modified="2006-07-11" version="1">MSTLEKIQSLAKVAEERERWRAEGRTVALANGVFDLLHVGHVRYLEGARALADVLVVAVNSDASTRAYKGPGRPYIPEGERAELVAALACTDRVIVFDESNVRVIIRALKPDVHVKGTDYTPDSIPEADEVRAYGGRTAVSGDPKDHSTTDLARRLGREGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3J4</accession>
    <name>Q1D3J4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ORF">MXAN_4611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4611"/>
    <dbReference type="EnsemblBacteria" id="ABF91526">
        <property type="protein sequence ID" value="ABF91526"/>
        <property type="gene ID" value="MXAN_4611"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4611"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_7"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="32711" checksum="0C6EA7829074C13E" modified="2006-07-11" version="1">MDMKGIILAGGSGTRLYPLTRVVSKQLLPVHDKPMIYYPLSTLMLAGIRDVLVISTPQDLPRFQELLGSGDQWGMRFSYAEQPKPDGLAQAFVIGRDFVGADSVSLVLGDNIFYGHGLSELVKRAASRTSGATVFGYYVKDPERYGVVELDAKNRAVSLEEKPLKPKSNYAVTGLYFYDNQVLDIAAGLKPSKRGELEITDVNAEYLRRGQLDVELMGRGYAWLDTGTHESLMQASNFIEIIERRQGLKVSCPEEIAFRMGYIGAQQLLTLAEPMLKNDYGQYLRALAENRGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q3</accession>
    <name>Q1D3Q3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554547.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4552"/>
    <dbReference type="EnsemblBacteria" id="ABF89717">
        <property type="protein sequence ID" value="ABF89717"/>
        <property type="gene ID" value="MXAN_4552"/>
    </dbReference>
    <dbReference type="GeneID" id="41361853"/>
    <dbReference type="KEGG" id="mxa:MXAN_4552"/>
    <dbReference type="HOGENOM" id="CLU_1904469_0_0_7"/>
    <dbReference type="OMA" id="GMKMATG"/>
    <dbReference type="OrthoDB" id="1798982at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="13273" checksum="D063471A91672C4F" modified="2006-07-11" version="1">MGGLKGIVGKVLNVVKPFVSAVNPLLGAAMGFASGLIQGKNPLQALMGAATDLIPGGGALKNTVGKFASKFLMDGAGGNSLLSGALNLATGKSKVTDVVGDLLKNTAKTGLSQLGMKNAAELSAQRMSQFLVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Y5</accession>
    <name>CH601_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL 1</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60 1</fullName>
            <shortName evidence="1">Cpn60 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL1</name>
        <name evidence="1" type="synonym">groL1</name>
        <name type="ordered locus">MXAN_4467</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554465.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D3Y5"/>
    <dbReference type="SMR" id="Q1D3Y5"/>
    <dbReference type="STRING" id="246197.MXAN_4467"/>
    <dbReference type="PRIDE" id="Q1D3Y5"/>
    <dbReference type="EnsemblBacteria" id="ABF87971">
        <property type="protein sequence ID" value="ABF87971"/>
        <property type="gene ID" value="MXAN_4467"/>
    </dbReference>
    <dbReference type="GeneID" id="41361777"/>
    <dbReference type="KEGG" id="mxa:MXAN_4467"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_7"/>
    <dbReference type="OMA" id="PYILINQ"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000256930" description="Chaperonin GroEL 1">
        <location>
            <begin position="1"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="547" mass="58146" checksum="8B84711C95EACB0F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q5</accession>
    <name>Q1D4Q5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R2K_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554196.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93049">
        <property type="protein sequence ID" value="ABF93049"/>
        <property type="gene ID" value="MXAN_4193"/>
    </dbReference>
    <dbReference type="GeneID" id="41361510"/>
    <dbReference type="KEGG" id="mxa:MXAN_4193"/>
    <dbReference type="eggNOG" id="ENOG5032W3Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093164_0_0_7"/>
    <dbReference type="OMA" id="FIRPCLD"/>
    <dbReference type="OrthoDB" id="1881710at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025643">
        <property type="entry name" value="R2K_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14243">
        <property type="entry name" value="R2K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R2K_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="270" mass="30175" checksum="14F8B1E79ED6E93F" modified="2006-07-11" version="1">MAHTANVPTPFSEATMHWVVQHNLFNEPGFHTLMGVLRRGEIPHTVVKVIPFDGGVEPTVDVDGPVIVMGSLSLTRYAKRRGWTPGAFLNDNFDFRIWREKLGHHLLNADAQVHRFGDVPPREGPFFIRPCLDDKSFSGMVTTWDDFNAWRASALALGEGATVDADTWVAVSPLKHIQREYRMVVVDGRVVTGSRYKLGDRVASSPEVEPDVRDFAQAMADTWTPDRAYVLDVFMHDGGLYVGELNNLNAAGFYAYDVAKMVDAIEAMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5A6</accession>
    <name>Q1D5A6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553997.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3987"/>
    <dbReference type="EnsemblBacteria" id="ABF91900">
        <property type="protein sequence ID" value="ABF91900"/>
        <property type="gene ID" value="MXAN_3987"/>
    </dbReference>
    <dbReference type="GeneID" id="41361319"/>
    <dbReference type="KEGG" id="mxa:MXAN_3987"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_7"/>
    <dbReference type="OMA" id="EPIKVFN"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="324" mass="34866" checksum="F733DB5218CD0177" modified="2006-07-11" version="1">MRVLVTGAAGFIAHHVSARLLARGDAVIGVDNLDPSGDVALKQARLTRLGTLPGATGFTFRPVDVTDSPSLRALFEEMRPEAVVHLAARVGVRAPAGTAQAYVDANVSGFLQVLEQASAARVRHLVYASSSSVYGAGSVPPFQEGAAADHPLSVYAATKRADELLAHAYSHLHGLPTSGLRFFTVYGPWGRPDMAPLRFLQAIRDGTELSLHGEGRMQRDFTYVEDVAEAVVRVLDRPLPGAPRHRVLNVGRGEPVSVRAFLSVLERILGARARVKSTPAQPGEMDATWADPSALERETGFRPRVSVEEGLTRLVAWFHEQSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5C7</accession>
    <name>Q1D5C7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553976.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3966"/>
    <dbReference type="EnsemblBacteria" id="ABF88455">
        <property type="protein sequence ID" value="ABF88455"/>
        <property type="gene ID" value="MXAN_3966"/>
    </dbReference>
    <dbReference type="GeneID" id="41361298"/>
    <dbReference type="KEGG" id="mxa:MXAN_3966"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_7"/>
    <dbReference type="OMA" id="AYSIQIT"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16378" checksum="D1478CAF7721AA83" modified="2006-07-11" version="1">MATVSRILVPVDLSDGSREVIDYAVKLARPFKASVEVVHAWEPPQYVAPDLLVAAPGWNSQSLEHVAVEAATKELTAQMNQGEPPGVPVSQKIVVGEAASTILDLAEQDKCDLIVMGTHGRRGLPRLLLGSVAQKVVARASCPVLTIHLSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5E7</accession>
    <name>Q1D5E7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyl carier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553956.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3946"/>
    <dbReference type="EnsemblBacteria" id="ABF88942">
        <property type="protein sequence ID" value="ABF88942"/>
        <property type="gene ID" value="MXAN_3946"/>
    </dbReference>
    <dbReference type="GeneID" id="41361278"/>
    <dbReference type="KEGG" id="mxa:MXAN_3946"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_21_1_7"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="83" mass="9059" checksum="7E336601DF68BA57" modified="2006-07-11" version="1">MTDEQIRGVVHQSIVRVLPRVRSNEIAGHLNLRELGADSVDRVEILTSILDSLRLQKTPLAKFADIRNIDALVAFLAGEVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5I0</accession>
    <name>Q1D5I0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA helicase DeaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">deaD</name>
        <name evidence="11" type="ORF">MXAN_3913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553923.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3913"/>
    <dbReference type="EnsemblBacteria" id="ABF88660">
        <property type="protein sequence ID" value="ABF88660"/>
        <property type="gene ID" value="MXAN_3913"/>
    </dbReference>
    <dbReference type="GeneID" id="41361244"/>
    <dbReference type="KEGG" id="mxa:MXAN_3913"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_7"/>
    <dbReference type="OMA" id="HLGDYMN"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
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    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="602" mass="65096" checksum="E19A413B6CFACC55" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5M6</accession>
    <name>Q1D5M6_MYXXD</name>
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        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase, subunit III</fullName>
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        </submittedName>
    </protein>
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        <name evidence="9" type="primary">coxC</name>
        <name evidence="9" type="ORF">MXAN_3867</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="43"/>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="207" mass="22831" checksum="8B9826A9D2973CF9" modified="2006-07-11" version="1">MEPRALHFGDEASRQDAAHLGMWIFLATEVLLFSVLFTAYALYRLTYPGVFQQAPAHMDVFLGTLNTFVLVVSSILVALAVDAIRNGRDFAAAALLALSVLLGIAFLFIKAAEYTKHVHDGALPGAWYAYEAFALPGANLYFTLYWVMTGVHAVHVLVGVGVLVTLALRTLAGEFGARFHTPVELGGMYWHLVDVVWLFLWPLLYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Q0</accession>
    <name>Q1D5Q0_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_3841</name>
    </gene>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553853.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3841"/>
    <dbReference type="EnsemblBacteria" id="ABF92600">
        <property type="protein sequence ID" value="ABF92600"/>
        <property type="gene ID" value="MXAN_3841"/>
    </dbReference>
    <dbReference type="GeneID" id="41361174"/>
    <dbReference type="KEGG" id="mxa:MXAN_3841"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_2_7"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="289" mass="33021" checksum="197179F5C3650C09" modified="2006-07-11" version="1">MSEDRRSPTDEAPREGELPRSPGDNFRIALPNFEGPLDLLLHLIKEHRVDIFDIPLALITEKYLEHLERMREINLDIAGEFLVMASTLAHLKSRMLLPRQDVASAQEGAEVLAVAEETEDPRAELVRRLLEYQKYKDAAEQLATQDLLGRDVFARNVPVEAVPIPEEEVGLQEFSVLKLVEALDRVLERLQPKLQHEVVRERVTLSEAILRVVERLRPHGQVLFESLFTEEETPSRQEVVITFLAILEMVKRRLIRVVQDEPLGPILLLPNGDALEKLAPTEVDDSDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Q6</accession>
    <name>Q1D5Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89533">
        <property type="protein sequence ID" value="ABF89533"/>
        <property type="gene ID" value="MXAN_3835"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3835"/>
    <dbReference type="HOGENOM" id="CLU_1048985_0_0_7"/>
    <dbReference type="OMA" id="DPFKVGK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188420" evidence="2">
        <location>
            <begin position="24"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="30520" checksum="C00BC55B27864E35" modified="2006-07-11" version="1">MTRRILPFLALLLASGCASQRLAGADLDRVRRPAFISRIEDGAGPKSHVFREDSAYRNKLKKLEPVEADRRLTVKLLQAVTRFEISERLRVTTLSQLPREFPWTHVVDPARVASVLESFLVEEVPANAPDYDLVASLGADTIVEFVIQDYGMRSDDGRAGAYLRGYGRMFTLDGRTEVWRRPFAMDQVAEGKEHLDPFKVGKDPSLFRAAMTSMLDEVARMFVKDLTPTDRAGAPPPRASAAASDVVPGKAGAPAPAPEATKPPEDELAPGELPDPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V1</accession>
    <name>Q1D5V1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacid CoA-transferase family, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553803.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D5V1"/>
    <dbReference type="STRING" id="246197.MXAN_3790"/>
    <dbReference type="EnsemblBacteria" id="ABF93152">
        <property type="protein sequence ID" value="ABF93152"/>
        <property type="gene ID" value="MXAN_3790"/>
    </dbReference>
    <dbReference type="GeneID" id="41361122"/>
    <dbReference type="KEGG" id="mxa:MXAN_3790"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_7"/>
    <dbReference type="OMA" id="FVKAWKG"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="25520" checksum="C954CC9BD9E2B432" modified="2006-07-11" version="1">MNKVYANADEAVADIPDGCTLMSGGFGLCGNPENLIEALHRKNVKDLTIISNNCGTTELGLGILLQNKQVKKMVSSYVGENKEFERQFLSGELEVELNPQGTLAERIRAGGCGIGGFFTPTGAGTQVAEGKETRVIDGRLHVLETPLKADFAIVRAWKADRWGNLVFRKTARNFSPMMCMAAKVTIVEAEHIVEPGELDPDLVHIPSIFVKRIVQAKNLQKWIERRTVRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V8</accession>
    <name>Q1D5V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase hexapeptide repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553796.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3783"/>
    <dbReference type="EnsemblBacteria" id="ABF89397">
        <property type="protein sequence ID" value="ABF89397"/>
        <property type="gene ID" value="MXAN_3783"/>
    </dbReference>
    <dbReference type="GeneID" id="41361115"/>
    <dbReference type="KEGG" id="mxa:MXAN_3783"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_7_1_7"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="171" mass="18278" checksum="FEE2A2B7A7F42494" modified="2006-07-11" version="1">MPQRPFRGVSPRVHPGCFVDDSAQLVGDIEVGEDSSIWFNCVLRGDVNPIRIGKRTNVQDLSLIHVTSGRSATTVGDDVTVGHHVILHGCTIGNRVLVGMGATVMDDAEVGDDCIIGAGALLTPGTKIPPGSLVVGSPGRVKRPITETEREFLLMSAQHYVLLAAEYHTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X2</accession>
    <name>Q1D5X2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553782.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3769"/>
    <dbReference type="EnsemblBacteria" id="ABF86939">
        <property type="protein sequence ID" value="ABF86939"/>
        <property type="gene ID" value="MXAN_3769"/>
    </dbReference>
    <dbReference type="GeneID" id="41361101"/>
    <dbReference type="KEGG" id="mxa:MXAN_3769"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_7"/>
    <dbReference type="OMA" id="HADQPGM"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="15414" checksum="B3A941DBEABCFCC6" modified="2006-07-11" version="1">MVPARRTVRVVAALIPRPEDGRQFLVQQRLPGGSRALLWEFPGGKVEAGETDAAALARECREELDVELAVGRRLWEGQHSYPDLTVELVLFLARIVSGEPRPLGAHALAFHTPAQMQSLPFCEADIPLLDDLVAGRLGALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X8</accession>
    <name>Q1D5X8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3763"/>
    <dbReference type="EnsemblBacteria" id="ABF90604">
        <property type="protein sequence ID" value="ABF90604"/>
        <property type="gene ID" value="MXAN_3763"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3763"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_3_7"/>
    <dbReference type="OMA" id="ATMETNQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="81"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="28316" checksum="A566518EBF02FCA0" modified="2006-07-11" version="1">MSHLPPARNAATRHPGVKPLGWGRGRRVRCRADMPPASLRKTLALVTCLLAGSVLAADSGKWTRKAAAGKDLYATLQTSEGTIVVRLFAKDAPKTVANFVGLAAGEKAWRDPKTGKMSKEPLYDGTVFHRVIPGFMIQGGDPTGTGFGDPGYRFADEFQSGRTFDKVGLLAMANAGPNTNGSQFFITTSTPGHLAGKHTIFGEVLSGYDVVEKISNRPRDNRDRPRTAVVLTRVVLGDKAPAGVTAPAASKGAAPKKDAGAKTVSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D601</accession>
    <name>Q1D601_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3738"/>
    <dbReference type="EnsemblBacteria" id="ABF86729">
        <property type="protein sequence ID" value="ABF86729"/>
        <property type="gene ID" value="MXAN_3738"/>
    </dbReference>
    <dbReference type="GeneID" id="41361071"/>
    <dbReference type="KEGG" id="mxa:MXAN_3738"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233929_0_0_7"/>
    <dbReference type="OMA" id="DWVECAP"/>
    <dbReference type="OrthoDB" id="1554008at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="23828" checksum="9323B91027D84D16" modified="2006-07-11" version="1">MRVLLVEDDASLREGMGELISELAQVHAVSTGEEAVEALEAGRFVLVISDLRISGGELGGRTVVEAARKRHQAVAIVSAATPDEVIQAVQPQVADAMLLKPFQIDDIYALVERFIALRQDVEQLATQGQRPAASVWSPRGAHVQIAREDALRAMWVSVTAGGDFGWTFHPTPSGVGVQVVEGVLEVDDVSYSAPGYFFLGAGQAPRMRSPEGCLVVAVGLKGQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D614</accession>
    <name>PSD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="1">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="1">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">psd</name>
        <name type="ordered locus">MXAN_3724</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553740.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D614"/>
    <dbReference type="SMR" id="Q1D614"/>
    <dbReference type="STRING" id="246197.MXAN_3724"/>
    <dbReference type="EnsemblBacteria" id="ABF89096">
        <property type="protein sequence ID" value="ABF89096"/>
        <property type="gene ID" value="MXAN_3724"/>
    </dbReference>
    <dbReference type="GeneID" id="41361057"/>
    <dbReference type="KEGG" id="mxa:MXAN_3724"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029061_4_0_7"/>
    <dbReference type="OMA" id="AIEWQLH"/>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00662">
        <property type="entry name" value="PS_decarb_PSD_B_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033178">
        <property type="entry name" value="PSD_type1_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000262125" description="Phosphatidylserine decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000262126" description="Phosphatidylserine decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="1">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00662"/>
        </source>
    </evidence>
    <sequence length="280" mass="30725" checksum="F3F7E06A91E638D0" modified="2006-07-11" version="1">MNDQTFMKLMQVLPKSALSTVVGMATRLPVPAPVHQAAMRAFAKAYNVDMEEAEHSFEHYPTFAQFFTRGLKPGLRPVDAGEKVVVSPVDGRVSQVGYSDYGRCLQAKGIEYTVDELLGDSEAAKPFYGGAWTTIYLSPRDYHRIHAPLGGTITGYAYIPGEFWPVNPASVKNKQSLFCVNERLVTYLDTVAGKCAVVKVGATCVSRIKAAYDEVTTHTGQPGKVHRYGSAMPVEKGGELGRFEMGSTVILLFEPKRVTWDDSLQEEAVVRLGKRIGVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D6</accession>
    <name>Q1D6D6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Very short patch repair protein</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vsr</name>
        <name evidence="7" type="ORF">MXAN_3599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553622.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3599"/>
    <dbReference type="REBASE" id="13175">
        <property type="entry name" value="V.MxaDKORF3598P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87499">
        <property type="protein sequence ID" value="ABF87499"/>
        <property type="gene ID" value="MXAN_3599"/>
    </dbReference>
    <dbReference type="GeneID" id="41360945"/>
    <dbReference type="KEGG" id="mxa:MXAN_3599"/>
    <dbReference type="eggNOG" id="COG3727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480538_0_0_7"/>
    <dbReference type="OMA" id="QMARIRG"/>
    <dbReference type="OrthoDB" id="2013215at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="6">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="21823" checksum="29761537F1178A79" modified="2006-07-11" version="1">MGLSRSEQMSRIRGRDTSPERLLRSALWRAGLRFRLHTRTTHGRPDVVFPRHKVAVFIDGCFWHGCPKHYVRPRTRDEFWSSKLRENVERDRRQTLLLEEGGWRVCRFWEHQIFESLAEVVEWVRQALQDGEWTPSASWRVVQVIPQVGEGDMEQRWMEELRDATETRTVVGRRSTKKWKRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6I5</accession>
    <name>RS16_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">MXAN_3545</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553574.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6I5"/>
    <dbReference type="SMR" id="Q1D6I5"/>
    <dbReference type="STRING" id="246197.MXAN_3545"/>
    <dbReference type="EnsemblBacteria" id="ABF88726">
        <property type="protein sequence ID" value="ABF88726"/>
        <property type="gene ID" value="MXAN_3545"/>
    </dbReference>
    <dbReference type="GeneID" id="41360890"/>
    <dbReference type="KEGG" id="mxa:MXAN_3545"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_7"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000049299" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="86" mass="9451" checksum="304F64B73A7D3EEB" modified="2006-07-11" version="1">MAVVLRLARAGVKKKPYYHVVATDSRNPRDGKFIEAVGAYDPNQEPPKVEFNEERLNYWLKTGATPSETVADLIKVAGKAKPAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6V6</accession>
    <name>Q1D6V6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cumA</name>
        <name evidence="7" type="ORF">MXAN_3420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553453.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3420"/>
    <dbReference type="EnsemblBacteria" id="ABF91184">
        <property type="protein sequence ID" value="ABF91184"/>
        <property type="gene ID" value="MXAN_3420"/>
    </dbReference>
    <dbReference type="GeneID" id="41360767"/>
    <dbReference type="KEGG" id="mxa:MXAN_3420"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_6_1_7"/>
    <dbReference type="OMA" id="LLPKQWG"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188274" evidence="3">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="70"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="375"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="53253" checksum="C62931AD675CEED3" modified="2006-07-11" version="1">MHRNRWFIAAALVALLAMLAALGLGQEDDAAMATLRQPRVAPPYPEDTPSTGRVREFELVAAPTALPLLDGRSLEVWAYNGQVPGPTLRATHGDTVRVRFTNKLPQPTTIHWHGIRLPNGMDGVPGVTQPPIPPGGTFLYEFKVKDAGTYWFHPHLRGSEQVERGLFGVLIVEDQKPGPFSRELVWVLDDWRLDASGQIDGRFNTRHDLAHDGRWGQVSTVNGAVQPEVPLQPGERVRLRMVNVANGRVFAPSFEGLGASVIAIDGLATDRPQPASRLELAPGNRVDLDFTVPEALSNQRMEVMDHFTRRPFPLATLVVSGEVVRPPEVAAVAPPPSPDLSPARALQPAETFRLNARRGGPFGIEWTINDEAFHHEGEHASAHHKVYRLPAHQWATLRFVNESSRLHPMHVHGQFFRVVARNGASVDEGHWRDTVLIRPRETVDVAMFPQDVGAWMLHCHIQEHAEAGMMTLVDVHAEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z9</accession>
    <name>Q1D6Z9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FHA/TonB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553410.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="DIP" id="DIP-60616N"/>
    <dbReference type="IntAct" id="Q1D6Z9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3377"/>
    <dbReference type="EnsemblBacteria" id="ABF92113">
        <property type="protein sequence ID" value="ABF92113"/>
        <property type="gene ID" value="MXAN_3377"/>
    </dbReference>
    <dbReference type="GeneID" id="41360724"/>
    <dbReference type="KEGG" id="mxa:MXAN_3377"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026767_0_0_7"/>
    <dbReference type="OMA" id="RIRRWKF"/>
    <dbReference type="OrthoDB" id="263730at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="682" mass="70383" checksum="F6CDB580E48B8864" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D721</accession>
    <name>Q1D721_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3355"/>
    <dbReference type="EnsemblBacteria" id="ABF86193">
        <property type="protein sequence ID" value="ABF86193"/>
        <property type="gene ID" value="MXAN_3355"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3355"/>
    <dbReference type="HOGENOM" id="CLU_2181027_0_0_7"/>
    <dbReference type="OMA" id="RVDVYWP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14052" checksum="7A39E5DEA0D15AD4" modified="2006-07-11" version="1">MRMTGIPGCVAKCVIRRNGATSMARWLTCSLLLVSLTGCFRMSLRSGAPRGGAPDEQTGVSLVAGLTTSNVVAPECQHGFSRVDVYWPWWSPVVYAATFGIVAPLRTEYVCAEAAAAAGSVRPEPVPSSHSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D744</accession>
    <name>Q1D744_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4 6">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553365.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3330"/>
    <dbReference type="EnsemblBacteria" id="ABF90346">
        <property type="protein sequence ID" value="ABF90346"/>
        <property type="gene ID" value="MXAN_3330"/>
    </dbReference>
    <dbReference type="GeneID" id="41360683"/>
    <dbReference type="KEGG" id="mxa:MXAN_3330"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_3_7"/>
    <dbReference type="OMA" id="RLMGITM"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="8">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="28338" checksum="75D2B9B7E9732D94" modified="2006-07-11" version="1">MRKLFCIFVAGVWTLFCFPLAILAMLLTLNPSRSVWVARELWSPVLLWAGGAKLEVIGQENVDPNRPTIYVANHQSTIDIPAHFLAVPIPFRYVAKTQLKWVPLIGWYLALAGHVFINRSNRSKAIASLNAAAAKIRGGTSIFLYPEGTRSTDGRVLPFKKGPFALALKARVPVCPVTIEGSGDLMPKSTWNITPGPIRVKIGKPIDTTTFAENDREGLARAVRAVIIADSLSLGGKGGDVDDAVAAAGAEGVSDARARALSSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D764</accession>
    <name>RL24_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">MXAN_3310</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553346.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D764"/>
    <dbReference type="SMR" id="Q1D764"/>
    <dbReference type="STRING" id="246197.MXAN_3310"/>
    <dbReference type="EnsemblBacteria" id="ABF92246">
        <property type="protein sequence ID" value="ABF92246"/>
        <property type="gene ID" value="MXAN_3310"/>
    </dbReference>
    <dbReference type="GeneID" id="41360663"/>
    <dbReference type="KEGG" id="mxa:MXAN_3310"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_7"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000067584" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="111" mass="12156" checksum="7E18EC3114ED44A6" modified="2006-07-11" version="1">MQKLKVGDTIQVMAGAEASEKNPATKRGKVLKIDREAERVTVEGLRLVKRHMKKTPQSPEGGIVEKPGTIALANVQVVCAKCDKPTRVGIRTEGEEGKKKRFCKNCDALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7K6</accession>
    <name>Q1D7K6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553213.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3164"/>
    <dbReference type="EnsemblBacteria" id="ABF89244">
        <property type="protein sequence ID" value="ABF89244"/>
        <property type="gene ID" value="MXAN_3164"/>
    </dbReference>
    <dbReference type="GeneID" id="41360523"/>
    <dbReference type="KEGG" id="mxa:MXAN_3164"/>
    <dbReference type="HOGENOM" id="CLU_1309040_0_0_7"/>
    <dbReference type="OMA" id="RAAMWGR"/>
    <dbReference type="OrthoDB" id="1959534at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="23973" checksum="719D5359675EC4B6" modified="2006-07-11" version="1">MHASVLMNTTAGPELTRTHPMNRIASALVAALLLTGSAQAQGYGPRPTRVERSELRDDRRDLEDLRNLLARFDAAWSSRSERQMANVEVSLRKLLRAELAESERELSKDRAQSRRTRRDARVAQWGGPRAAMWGRASAAEARNDLRAEHAALRTRKAIARELDEIEGLRQPGALNYKRTLILELIQVAERELNQTRREVRDDRRTPGRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U9</accession>
    <name>Q1D7U9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ORF">MXAN_3071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553121.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3071"/>
    <dbReference type="EnsemblBacteria" id="ABF88361">
        <property type="protein sequence ID" value="ABF88361"/>
        <property type="gene ID" value="MXAN_3071"/>
    </dbReference>
    <dbReference type="GeneID" id="41360433"/>
    <dbReference type="KEGG" id="mxa:MXAN_3071"/>
    <dbReference type="HOGENOM" id="CLU_1764932_0_0_7"/>
    <dbReference type="OMA" id="NLMVEWL"/>
    <dbReference type="OrthoDB" id="1815554at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="16187" checksum="BF7E2723D30FF7E1" modified="2006-07-11" version="1">MATASEASQQANRSAMDPKRLVVIFYLLVGIVLALFLERLLGLLWARFSWSDPVLIEGLDWKVSTLVSYVLAVGLAVGAYFHPRTHALSIDVASELMKVTWPTWSETKASTMAVVVASLVAAVILFCIDTAAYNLMVEWLPAMWGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8F9</accession>
    <name>Q1D8F9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative lantibiotic ABC transporter, permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_2853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552914.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2853"/>
    <dbReference type="MEROPS" id="C39.005"/>
    <dbReference type="EnsemblBacteria" id="ABF90094">
        <property type="protein sequence ID" value="ABF90094"/>
        <property type="gene ID" value="MXAN_2853"/>
    </dbReference>
    <dbReference type="GeneID" id="41360223"/>
    <dbReference type="KEGG" id="mxa:MXAN_2853"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_7"/>
    <dbReference type="OMA" id="NAKTQSH"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="26"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="490"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="524"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="733" mass="80050" checksum="342C4EC0AE429C15" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8W9</accession>
    <name>Q1D8W9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552755.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2687"/>
    <dbReference type="EnsemblBacteria" id="ABF90223">
        <property type="protein sequence ID" value="ABF90223"/>
        <property type="gene ID" value="MXAN_2687"/>
    </dbReference>
    <dbReference type="GeneID" id="41360065"/>
    <dbReference type="KEGG" id="mxa:MXAN_2687"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854798_0_0_7"/>
    <dbReference type="OMA" id="VDMMLKG"/>
    <dbReference type="OrthoDB" id="1939138at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA" evidence="1">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="31862" checksum="A7336ED2F0CCE346" modified="2006-07-11" version="1">MTGASGAAFYDGRVCVAATGVVTATRARGRRRRRPALVVWPERPTGRDARVLARMSAFGAVLLAAHARESDAAARHVHLLKTQRRLERRVVNQEHRRSRASHDLRTPLMVIKGYVDMMLKGTAGGLTAPIQRYLERLRRSADDQSAIIERRLAKVQDEGVEDLRPLLRTAFIPAARGQRIMDTTMTLPDRPVAIPGPRDDVELLVRVLARTVAASGAPTAVRVEAAGDASVWQLRINIRGGKPLPEKTVTLLRHLTQRLRGGLSLPEETGNGWVVHLPVDDTVPVAPRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Z7</accession>
    <name>Q1D8Z7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hemD</name>
        <name evidence="3" type="ORF">MXAN_2657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552727.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2657"/>
    <dbReference type="EnsemblBacteria" id="ABF89601">
        <property type="protein sequence ID" value="ABF89601"/>
        <property type="gene ID" value="MXAN_2657"/>
    </dbReference>
    <dbReference type="GeneID" id="41360033"/>
    <dbReference type="KEGG" id="mxa:MXAN_2657"/>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_7"/>
    <dbReference type="OMA" id="VWAVGKT"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="25"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="27382" checksum="9DCFCE5762495939" modified="2006-07-11" version="1">MERRLEGKRVLVTRPRERAEELCFLLEDEGAEVLSVPLLELHPPEDPRPLASAAEHIQRYTWVVFASPTGVDALMEALREAGTQDRIQRVKVATVGPRTTRAAEGYGLVVVAEPSEGTGAALLNLIKDALQPGDEVLLPAAEEGRRELEDGLREYGLLVTRVTAYRATPAPLPPESLALLDASPPDVVLFASPRTAEAFVEEAGRERLATARVVAIGPTTASALERLGVPAAAVAERPTPESLVDAAVLAVTSTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D904</accession>
    <name>Q1D904_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552720.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86138">
        <property type="protein sequence ID" value="ABF86138"/>
        <property type="gene ID" value="MXAN_2650"/>
    </dbReference>
    <dbReference type="GeneID" id="41360026"/>
    <dbReference type="KEGG" id="mxa:MXAN_2650"/>
    <dbReference type="eggNOG" id="ENOG5030TF6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2155616_0_0_7"/>
    <dbReference type="OMA" id="CSAHYQA"/>
    <dbReference type="OrthoDB" id="1809111at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="11941" checksum="C4E64337B2E4BADA" modified="2006-07-11" version="1">MARPRKELSTVPLTPAMVNWAEALGDAIGRGMLRALNDGMPRLGSTSPSSTALTAGRRRGRPPKVMAGASLVSLDRRCTMEGCSREQRSKGLCSAHYQAERRRQISGSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D926</accession>
    <name>Q1D926_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552698.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2628"/>
    <dbReference type="EnsemblBacteria" id="ABF90691">
        <property type="protein sequence ID" value="ABF90691"/>
        <property type="gene ID" value="MXAN_2628"/>
    </dbReference>
    <dbReference type="GeneID" id="41360005"/>
    <dbReference type="KEGG" id="mxa:MXAN_2628"/>
    <dbReference type="HOGENOM" id="CLU_1282079_0_0_7"/>
    <dbReference type="OMA" id="NRYAQVH"/>
    <dbReference type="OrthoDB" id="1657354at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="24083" checksum="93B9531A3801C8C4" modified="2006-07-11" version="1">MSEQLPQSPSEEARARRIAELEFRLSRRRVGVRPMAAVMAIAVGLVLLGMQWKDLSYFLSPSVPLTLGAEGAYRFEALVSNRYAQVHGVPTVRGAYERADGALYVLVGLRDSPFVVRRPALPGEQWTDGRPPPQPDQRPFAVRGRLLAQADARRYRDALALMERMGELQPRDGRLWLLIEGERPGTDRGLLLVCLALVTFVVLNAMLLVRGLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D985</accession>
    <name>Q1D985_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2569"/>
    <dbReference type="EnsemblBacteria" id="ABF90666">
        <property type="protein sequence ID" value="ABF90666"/>
        <property type="gene ID" value="MXAN_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2569"/>
    <dbReference type="HOGENOM" id="CLU_137925_0_0_7"/>
    <dbReference type="OMA" id="DQINIHI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21615" checksum="BAEF0BA3F74CE616" modified="2006-07-11" version="1">MGLGLRYSGMTPSLPAAVTLALPRCVPWSIVRAVSTPRRHRLVLSGLLLACLVGCLPHVQEPGDYVFEPVEVLRDDCGLLETNRSQLYGTLQISGRVVRLDFGFLDSHLVGYFLEDGDHFSIDGSVVKAAAEVNGQECLLDQINIHIDGTTQCETQFNGVLRVRYDTRRPDECVCEMWLRYEAVKESKRCDTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E5</accession>
    <name>Q1D9E5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T2SSG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552580.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2509"/>
    <dbReference type="EnsemblBacteria" id="ABF91017">
        <property type="protein sequence ID" value="ABF91017"/>
        <property type="gene ID" value="MXAN_2509"/>
    </dbReference>
    <dbReference type="GeneID" id="41359887"/>
    <dbReference type="KEGG" id="mxa:MXAN_2509"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1795308_0_0_7"/>
    <dbReference type="OMA" id="LMGRFPS"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="3">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16611" checksum="A0545140B9FBB13E" modified="2006-07-11" version="1">MGMKEHDAIPSPTPSHEGPDRRRRLGRFLLAFVFVAATGLAFTLVYVTEDRTLDTNQRRARTDIRQLESMFKSHHRLMGRFPSQAEGFTPLIQARILDRVPEDPWGHPYVYWMDGSTGAVISYGADGKPGGTGPDADLSSGGVLAAGWAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9P8</accession>
    <name>Q1D9P8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552480.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2405"/>
    <dbReference type="EnsemblBacteria" id="ABF91839">
        <property type="protein sequence ID" value="ABF91839"/>
        <property type="gene ID" value="MXAN_2405"/>
    </dbReference>
    <dbReference type="GeneID" id="41359789"/>
    <dbReference type="KEGG" id="mxa:MXAN_2405"/>
    <dbReference type="eggNOG" id="COG1297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010539_2_1_7"/>
    <dbReference type="OMA" id="WPGVMVM"/>
    <dbReference type="OrthoDB" id="809815at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="OPT"/>
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        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="527"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="590"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="65566" checksum="07A1ACA6784370F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9S2</accession>
    <name>Q1D9S2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552456.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2381"/>
    <dbReference type="EnsemblBacteria" id="ABF92278">
        <property type="protein sequence ID" value="ABF92278"/>
        <property type="gene ID" value="MXAN_2381"/>
    </dbReference>
    <dbReference type="GeneID" id="41359766"/>
    <dbReference type="KEGG" id="mxa:MXAN_2381"/>
    <dbReference type="eggNOG" id="ENOG502ZKKT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081462_0_0_7"/>
    <dbReference type="OMA" id="WHYTTPL"/>
    <dbReference type="OrthoDB" id="1217451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="29490" checksum="7165166CF3CC0325" modified="2006-07-11" version="1">MKAFPKEFADWLTPRGRRILDGRERDVVGALLDPARPFVSLQGVIDPRRAAACRDALDAAMRETMVPMEDPIPADSISGQTMNYMELLPKTVRVSTALLEGRRSRSWRAAESVGLTDMLRSDTFAGFAAAVTGRALRRKWGIQALCYGPGDYSGPHNDHHPEEPEARDGYVDMHVSLTLPGVDHQYLIYAQDGHFTQMTPVSTVGGITVYRLPFWHYTTPLLARKGKEETSRRWVLLGTFLDAAPGARPATTILPAQPPAKRLPAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z7</accession>
    <name>DEOD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="2">PNP</shortName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">deoD</name>
        <name type="ordered locus">MXAN_2306</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552381.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D9Z7"/>
    <dbReference type="SMR" id="Q1D9Z7"/>
    <dbReference type="STRING" id="246197.MXAN_2306"/>
    <dbReference type="EnsemblBacteria" id="ABF90899">
        <property type="protein sequence ID" value="ABF90899"/>
        <property type="gene ID" value="MXAN_2306"/>
    </dbReference>
    <dbReference type="GeneID" id="41359693"/>
    <dbReference type="KEGG" id="mxa:MXAN_2306"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_7"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000069638" description="Purine nucleoside phosphorylase DeoD-type">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P50389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <sequence length="239" mass="25703" checksum="E63417EF0A2CB905" modified="2006-07-11" version="1">MATPHISAAPGDFADVVLMPGDPLRARYISDRFLEGAREVTSVRNMLGFTGTFRGRRVSVMGHGMGVPSISIYATELIKTYGVRVIIRVGSCGALSTDVKVREVIVATGAGTDSNVNRMRLMGHDFAAVADFTLARRAMEAAERRNKPVRAGPVFTSDLFYHPQEQLNATLARMGVLAVEMEVAGLYGVAAESGARALGLLTVSDHIITGESLTPQERQTTFDEMIELALDVAHAEPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA26</accession>
    <name>Q1DA26_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Vaudin M."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="gene ID" value="MXAN_2276"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="16842" checksum="91F465F7F883F2D4" modified="2006-07-11" version="1">MNLKAIAALSSLLALTAQVACTSPSKSNPTPSDSSDTTKAGAPVKVDAKLGEDQARVSLRFDAPATDVKVSLSGVDGLEVKSSATPVSGGSFTPDAVSEFDVSFTPGEGQSHLVVTVTGDFRGAHLSRVFSFAVGTPTAAQQKTEGTTVTGDDGQPIKVMPSSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="302" mass="33903" checksum="6EAD60BCDF3600C8" modified="2006-07-11" version="1">MPEFGEAVAGGDGADDGHPEDCVFCAEWPRELKGYKTKHGLLKDEDDLAESLRSNAKELTTDKKVGPVYPLPGGSDPTMGWVAKAGALEEFEVEIGATPHHIIPGKASMAKSRLEQWTRAEKGKIKEDIGYSIDCARNGVFLPKLPDLYGTKHKVPGVTMAQFYGQTWRALSPASKEGVGFLVMKDTWLQLHYTDHSKPYKTSPTMNYDKETRLECDQLAHLAERFRIVCERSKDDDGKRYPPYSLVHLINQKSDFFKMRITGRPDQWKSWVSTLAEDLSMAVRQGRELLVSKLALTKKTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAV1</accession>
    <name>Q1DAV1_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
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        <name evidence="3" type="ORF">MXAN_1987</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABF92053">
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zincin_1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB06</accession>
    <name>Q1DB06_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">MXAN_1923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1923"/>
    <dbReference type="EnsemblBacteria" id="ABF85897">
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        <property type="gene ID" value="MXAN_1923"/>
    </dbReference>
    <dbReference type="GeneID" id="41359337"/>
    <dbReference type="KEGG" id="mxa:MXAN_1923"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010311_0_0_7"/>
    <dbReference type="OMA" id="FVETQFT"/>
    <dbReference type="OrthoDB" id="359432at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
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    </dbReference>
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        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188089" evidence="3">
        <location>
            <begin position="23"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="809" mass="90775" checksum="E4D6ECFF670D7BC4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB22</accession>
    <name>Q1DB22_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF88161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88161">
        <property type="protein sequence ID" value="ABF88161"/>
        <property type="gene ID" value="MXAN_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1906"/>
    <dbReference type="HOGENOM" id="CLU_2509209_0_0_7"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="85" mass="9292" checksum="427097B522375E24" modified="2006-07-11" version="1">MRAIRQLPGARWATALNSGPVPLHLMEELDERVVQKRQAGLHVPAGAEEKTKAVDEEAPDSCRDDAAFPTPLVKPLLRLLVSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD9</accession>
    <name>Q1DBD9_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">MXAN_1786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92429">
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        <property type="gene ID" value="MXAN_1786"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5032WT5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158539_0_0_7"/>
    <dbReference type="OMA" id="MWATISD"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="12542" checksum="BD614A5CB77C4496" modified="2006-07-11" version="1">MSASPEAQQAEAGLVSAHVHRVRRSKVRFREGAPPSPREVSRRPAHVAGMLALAHHLESAIERGLVASAADVAGQLGFTWARVTHLLDLRLLAPDIQEEVLFLEAVDGEEQVVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ2</accession>
    <name>Q1DBQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88239">
        <property type="protein sequence ID" value="ABF88239"/>
        <property type="gene ID" value="MXAN_1669"/>
    </dbReference>
    <dbReference type="GeneID" id="41359109"/>
    <dbReference type="KEGG" id="mxa:MXAN_1669"/>
    <dbReference type="HOGENOM" id="CLU_2807923_0_0_7"/>
    <dbReference type="OMA" id="DEVLHTD"/>
    <dbReference type="OrthoDB" id="2100514at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="67" mass="7661" checksum="B738BE858DA829FC" modified="2006-07-11" version="1">MVLELSHQQIHVLHACLSESIAELHDEVLHTDERDLREALKLRLDHLQGIQRQVEALMQAEEAASPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBV1</accession>
    <name>Q1DBV1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551731.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1620"/>
    <dbReference type="EnsemblBacteria" id="ABF88966">
        <property type="protein sequence ID" value="ABF88966"/>
        <property type="gene ID" value="MXAN_1620"/>
    </dbReference>
    <dbReference type="GeneID" id="41359064"/>
    <dbReference type="KEGG" id="mxa:MXAN_1620"/>
    <dbReference type="eggNOG" id="COG0417">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_1_7"/>
    <dbReference type="OMA" id="SHEPKNY"/>
    <dbReference type="OrthoDB" id="261704at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="8">
        <location>
            <begin position="196"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="7">
        <location>
            <begin position="448"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="804" mass="88933" checksum="2BF1019F31595370" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM7</accession>
    <name>Q1DCM7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551456.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89247">
        <property type="protein sequence ID" value="ABF89247"/>
        <property type="gene ID" value="MXAN_1339"/>
    </dbReference>
    <dbReference type="GeneID" id="41358785"/>
    <dbReference type="KEGG" id="mxa:MXAN_1339"/>
    <dbReference type="HOGENOM" id="CLU_1584718_0_0_7"/>
    <dbReference type="OMA" id="DRVAGCI"/>
    <dbReference type="OrthoDB" id="1335328at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20825" checksum="2BD37943567FDE12" modified="2006-07-11" version="1">MMGSQRVRSRMDIHASHEGLKMTPVVTVFGRKAQAAAVLLFASLWGACDGTREDFIGARVKDTCGAAWPVCDRVAGCILGSESYSEGRFPGRQQLIVQLKEASTVKVSLFLEDVTAAGSETVMLFHEEGCRARIRRATEGRAVLDVMERQGSFTEEAELTGVGDHLIEFESDMQARYIIKVDVTPLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCW1</accession>
    <name>Q1DCW1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1255"/>
    <dbReference type="EnsemblBacteria" id="ABF87239">
        <property type="protein sequence ID" value="ABF87239"/>
        <property type="gene ID" value="MXAN_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1255"/>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041667_0_0_7"/>
    <dbReference type="OrthoDB" id="1766956at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032871">
        <property type="entry name" value="AHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14412">
        <property type="entry name" value="AHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="456" mass="49430" checksum="3E45649086FAF2DB" modified="2006-07-11" version="1">MTGCPSRGTSMLLRWALLPLLLFAVSCSASRRVRLDIGDEAPILVAPPDATEANLRASQVEAGAFQEALARLAWDVRPARQPLNHARLLMGVPRRSGVYWYEGRSQRLIPQDESDQGPRLRMSYADDELTRAYGPWCHRKGQSRDCLRLLDEGPLIASDGKYALAMAIAMDSVWEETTEALEGMTDPQAVMATVTASVSMYLLLWALPEPTSKGVAALITATAIAYLGVDMVWRLLDGWVSLVRTVDHATTFEQLSEAGESYGEVLGVNAARVFVMLATAAIGSTAGLAAKSSSLPNSAQAALAIESQAGLRFTSIGNVGSVAMTAEGFTVALAPTAVAMSTQDSSKRWTHRHHLATNKNSVSTARGGPWTPRFEEFFKKAGMELKDPENIVPVQGHHGPHPQEYHALVFARLRDATRACRTVESCRKALTSALSEMAEEVITQGTELNRLVTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDA7</accession>
    <name>Q1DDA7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PT repeat/DnaJ domain/tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551226.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1106"/>
    <dbReference type="EnsemblBacteria" id="ABF89631">
        <property type="protein sequence ID" value="ABF89631"/>
        <property type="gene ID" value="MXAN_1106"/>
    </dbReference>
    <dbReference type="GeneID" id="41358558"/>
    <dbReference type="KEGG" id="mxa:MXAN_1106"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015378_0_0_7"/>
    <dbReference type="OMA" id="VEDGTWA"/>
    <dbReference type="OrthoDB" id="429217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="684"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="772"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="892" mass="90956" checksum="4D51DC400274BD2F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDF7</accession>
    <name>Q1DDF7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551176.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1055"/>
    <dbReference type="EnsemblBacteria" id="ABF85997">
        <property type="protein sequence ID" value="ABF85997"/>
        <property type="gene ID" value="MXAN_1055"/>
    </dbReference>
    <dbReference type="GeneID" id="41358508"/>
    <dbReference type="KEGG" id="mxa:MXAN_1055"/>
    <dbReference type="HOGENOM" id="CLU_077132_0_0_7"/>
    <dbReference type="OMA" id="VEPCTEC"/>
    <dbReference type="OrthoDB" id="1381895at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26575" checksum="C268C2A61A7D4921" modified="2006-07-11" version="1">MRFYRVEASTTSRFTGNLSRAAHKWGLPGVEPCTECGVGGGWAGLQYPCVDLSSFSKAELKPFSDPWPVPFEVFARLRERVRPLAPEGAVLEPGTRLGPLSGVATGAFGHLALQDWTLVIRDEALEVLQGEGVRGLTGCRLDVTFRGKNPPVLRELQLALHGRLHPDCFVHPRAPTCAKCGSEASERLPDTYWLARETLPVEVDLFRLRDYPALVIATERMVVAADRLKLEGVTFQPLDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX7</accession>
    <name>Q1DDX7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0885"/>
    <dbReference type="EnsemblBacteria" id="ABF90027">
        <property type="protein sequence ID" value="ABF90027"/>
        <property type="gene ID" value="MXAN_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0885"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070819_0_0_7"/>
    <dbReference type="OMA" id="STWDYSW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="34326" checksum="9B7A255DD726AB65" modified="2006-07-11" version="1">MTHRESPARRCRTRYKPLHVSTPGARVMDVAVLTFEGLPQLDAFDASLLPALAALGVEARPVVWDDPAMDWKTVRLALVRNTWDSHLRRDAFVAWADKVGRLTQLHNPAPVLRWNTHKHYLRELEEKGVLVTPTTWVRKGDTLDVGELALRHSWDAVVLKPAVSAGALKTHVFPRAEAPAATARLAELTREGDVMVQPYLTAFETEGERSYVFFDGVLSHAVRRPPTLLDAPRGFSEPTAFTPEDAAELRLAESVLEAVGRPLLYARVDVATDNAGQSRLQELEATEPRLFLSLDAGAADRLARAIVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEI4</accession>
    <name>Q1DEI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0671</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">DK 1622</strain>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550802.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0671"/>
    <dbReference type="EnsemblBacteria" id="ABF90881">
        <property type="protein sequence ID" value="ABF90881"/>
        <property type="gene ID" value="MXAN_0671"/>
    </dbReference>
    <dbReference type="GeneID" id="41358146"/>
    <dbReference type="KEGG" id="mxa:MXAN_0671"/>
    <dbReference type="eggNOG" id="COG1628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_1_0_7"/>
    <dbReference type="OMA" id="RDGWNAT"/>
    <dbReference type="OrthoDB" id="1503857at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLH55591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20523" checksum="1D2BE8E21636E1E1" modified="2006-07-11" version="1">MRLPRFPRVIGFDDGPFARRPGAAVPLAGVVCGGTRFEGLVWGRVRRDGWNATREVCRLLEGGKFLPQLHLVLLDGIAFGGFNVVDLPLLASRLKRPCVAVMRRPPDLDAVERALRRLPRADARWAKLKRAGPIHQLGGFTFQVQGAEPAWVAEALARVTDRGLVPEALRLAHLIGSAVVTGQSSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP7</accession>
    <name>Q1DEP7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0608"/>
    <dbReference type="EnsemblBacteria" id="ABF92708">
        <property type="protein sequence ID" value="ABF92708"/>
        <property type="gene ID" value="MXAN_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0608"/>
    <dbReference type="HOGENOM" id="CLU_1946494_0_0_7"/>
    <dbReference type="OMA" id="QLYKGQF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="13977" checksum="C82353A35C83371A" modified="2006-07-11" version="1">MAMEVPPWGPLIAAGRGETVPLVVRASGRSLQGFRGPGPSFIWGSGLETAMADIIRERRFNFLIAGVLSLVIPGLGQLYKGQFLRAVLWFLMVGAGYWFFFIPGFVLHFFCVLGAAFGSAGSDRIRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ7</accession>
    <name>Q1DEQ7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550729.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88233">
        <property type="protein sequence ID" value="ABF88233"/>
        <property type="gene ID" value="MXAN_0598"/>
    </dbReference>
    <dbReference type="GeneID" id="41358076"/>
    <dbReference type="KEGG" id="mxa:MXAN_0598"/>
    <dbReference type="eggNOG" id="ENOG502ZAX0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1738538_0_0_7"/>
    <dbReference type="OMA" id="DCQDSDF"/>
    <dbReference type="OrthoDB" id="1594721at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="168" mass="18841" checksum="470E8EEA3567E44F" modified="2006-07-11" version="1">MEHCGARQALRGLTMAIESLLTEISRAHFPHPPVTAARIAAFEAQMGWRLDDDLRAFYLHCDGAELFRRLPDANYSILSLEGIAAATPRLRQRAQGASETASLYPLVDCQDSDFVLVNVANTGGPYPLFDAYHETYPREVRKIADSFSDFLERALASGDEFFWLDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ8</accession>
    <name>Q1DEZ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase, flavin-contaning</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550638.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87866">
        <property type="protein sequence ID" value="ABF87866"/>
        <property type="gene ID" value="MXAN_0506"/>
    </dbReference>
    <dbReference type="GeneID" id="41357992"/>
    <dbReference type="KEGG" id="mxa:MXAN_0506"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_3_0_7"/>
    <dbReference type="OMA" id="FMEWEHH"/>
    <dbReference type="OrthoDB" id="324612at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="453" mass="51913" checksum="CA1959196A78E3E5" modified="2006-07-11" version="1">MALRVAIIGAGPSGLAQLRAFESAARKGAEIPEIVCFEKQEDWGGLWNYTWRTGLGRYGEPVHGSMYRHLWSNGPKEALEFADYSFDEHFGRPIPSYPPREVLYDYIRGRVEKCDVRKYIQFNTIVRWLSWSEETRKFTVVVDDLAKREVREESFDRVVNATGHFSTPNVPFFEGIDSFPGRVLHAHDFRGAEEFAGKNLLLIGSSYSAEDIGVQCHKLGAKSVTISYRSAPMGFRWPMGMKEVPLVKRFEGNRAHFADGTSATLDAVILCTGYQHKYRFLPNALRLESHNRLYPPGLYKGVFWQGQPELAYLGMQDQYYTFNMFDAQAWLVRDVIMGRTALPSAEEREADIAAWVEREEGIQDSFGAVDFQTAYIRDLLDRTDYPGFSVEKVAELLKQWLRDKQEDILGYRDRTFTSIVTGTRATPHRRKWMDELDDSAESFLAEAPERRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF05</accession>
    <name>Q1DF05_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0498"/>
    <dbReference type="EnsemblBacteria" id="ABF88336">
        <property type="protein sequence ID" value="ABF88336"/>
        <property type="gene ID" value="MXAN_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0498"/>
    <dbReference type="HOGENOM" id="CLU_480461_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="567" mass="61382" checksum="C5CC75ED55A95A6C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF47</accession>
    <name>Q1DF47_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase, zinc-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0456"/>
    <dbReference type="EnsemblBacteria" id="ABF91173">
        <property type="protein sequence ID" value="ABF91173"/>
        <property type="gene ID" value="MXAN_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0456"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_7_7"/>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="36268" checksum="345D269B376F9ECE" modified="2006-07-11" version="1">MEGSMRAMVLREVGQPLHETRLPIPRPGPEELLLRVRACAVCRTDLHVVDGELPKPKLPLVPGHEIVATVEAAGERATAIPVGTRVGVPWLGWSCGHCRFCLAGQENLCEQARFTGYQLDGGYAEFTVAHQRFCFPLPPEYTDVHAAPLMCAGLIGFRSLRMAGRERRLLGFYGFGAAAHLLIQVARHQGRRVFAFTRPGDVEGQRFARELGAEWAGDSDTVPPERLDAAILFAPVGALVPAALRAVDKAGVVVCGGIHMSDIPAFPYALLWEERVVRSVANLTRADALDFLALAPKVPVRTLVQTFPLSAANDALTALRRGQVHGAAVLEVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF50</accession>
    <name>Q1DF50_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative general stress protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550586.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0453"/>
    <dbReference type="EnsemblBacteria" id="ABF87816">
        <property type="protein sequence ID" value="ABF87816"/>
        <property type="gene ID" value="MXAN_0453"/>
    </dbReference>
    <dbReference type="GeneID" id="41357946"/>
    <dbReference type="KEGG" id="mxa:MXAN_0453"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_1_1_7"/>
    <dbReference type="OMA" id="AKAWWDS"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="20093" checksum="E80AC3BD1B71F177" modified="2006-07-11" version="1">MARKKKDTQDVTEHFDDLIKDIKVAMMTTVEADGSLRSRPMWTHARDFDGELWFFTREHSPKVDEVTHDHHVNLAYSDPTRDRYVSVSGRCRLVLDKEKARALWNPTLKAWFPDGLDDPELALLCVRVEKAEYWDTPSSRMVQLTGMVKAAFTGQPYAPGDHQKLDLDDSAPLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF85</accession>
    <name>Q1DF85_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550551.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0417"/>
    <dbReference type="EnsemblBacteria" id="ABF86023">
        <property type="protein sequence ID" value="ABF86023"/>
        <property type="gene ID" value="MXAN_0417"/>
    </dbReference>
    <dbReference type="GeneID" id="41357911"/>
    <dbReference type="KEGG" id="mxa:MXAN_0417"/>
    <dbReference type="eggNOG" id="COG4253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184015_0_0_7"/>
    <dbReference type="OMA" id="LTHVWQH"/>
    <dbReference type="OrthoDB" id="1322335at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="27099" checksum="F358226DD250B6DE" modified="2006-07-11" version="1">MSHAATFSERLVDAGRGLLTGVSSASVGVARSVGVVLKAMGGGVAQCVRGRPREGLPQLGQGLTRVAQLPADAVLMVGGRVLSSVQVLVGLEPPGRRLSAEEIARLRPIFGDSLNYAVVRVKVGRLGLLGLPGRAFAHGNTVFVPPRSGGVDFGLLVHELTHVWQHQHGGTAYLSAALAAQWSGDGYDWRKGVSREKRWAQLNPEQQAQLIEDAAVAGLIPFTTSVSPRMKLRGWSDAALDLLDEAVVCLHSGRGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF89</accession>
    <name>Q1DF89_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0413"/>
    <dbReference type="EnsemblBacteria" id="ABF87639">
        <property type="protein sequence ID" value="ABF87639"/>
        <property type="gene ID" value="MXAN_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0413"/>
    <dbReference type="eggNOG" id="ENOG5030TP6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094933_0_0_7"/>
    <dbReference type="OMA" id="RYQGWRS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="27323" checksum="3773CA0E08760EBB" modified="2006-07-11" version="1">MPATGTLWAVGPPAPHQGSAPPRTTSSFSPVPAMTASGTRGHNDNRLPMPGNPPVRQASQRLFSCTTPKTRVTGWRANYVQSMRTSRIFTAALLAAAGSAWAQPVQYLDLRTPRVALNARVTDRDLTSPDLQVGFSDGSLRGRAFGRPLNLTLDAARIRGIYGSGPVDLRMTQEEGALHAKGTFGGQLTDFQVTPQTLKGDVGRCSYQLKASEEGRYQGWRSCLAGLENPVSLSIPPAIGGDDARLVATLALILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF92</accession>
    <name>Q1DF92_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550544.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0410"/>
    <dbReference type="EnsemblBacteria" id="ABF91782">
        <property type="protein sequence ID" value="ABF91782"/>
        <property type="gene ID" value="MXAN_0410"/>
    </dbReference>
    <dbReference type="GeneID" id="41357904"/>
    <dbReference type="KEGG" id="mxa:MXAN_0410"/>
    <dbReference type="HOGENOM" id="CLU_1609048_0_0_7"/>
    <dbReference type="OMA" id="CVDKRAL"/>
    <dbReference type="OrthoDB" id="1522822at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="18170" checksum="8F955A20E56BAB4B" modified="2006-07-11" version="1">MAPLLDVLTRERLLKDRAAAAALLPRGEPPHVSMLRLCDAGLLEGGLSVGYGVRADELVGPLTTAMGGAARRFKVVDVRERPVLELHVMGGDVTERWEVEDLSALVHNLNSLYRDAPDVRAVVELGEWEDALQLWCVDKRALPRLARQPFFAPRNARALMNPSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFA3</accession>
    <name>Q1DFA3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550534.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0399"/>
    <dbReference type="EnsemblBacteria" id="ABF89476">
        <property type="protein sequence ID" value="ABF89476"/>
        <property type="gene ID" value="MXAN_0399"/>
    </dbReference>
    <dbReference type="GeneID" id="41357892"/>
    <dbReference type="KEGG" id="mxa:MXAN_0399"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341560_0_0_7"/>
    <dbReference type="OMA" id="MGTHFAA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="658"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="875" mass="94857" checksum="BB54BD58354B5BBD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFA5</accession>
    <name>Q1DFA5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90485">
        <property type="protein sequence ID" value="ABF90485"/>
        <property type="gene ID" value="MXAN_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0397"/>
    <dbReference type="HOGENOM" id="CLU_3063772_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="53" mass="5696" checksum="31263D6751373290" modified="2006-07-11" version="1">MQLKFVGELGFLDVLAHSIRQGRDGTLFRHTDDGGHAAGRELPLPALPGQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB6</accession>
    <name>Q1DGB6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exoribonuclease II</fullName>
            <ecNumber evidence="3">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550173.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DGB6"/>
    <dbReference type="STRING" id="246197.MXAN_0024"/>
    <dbReference type="EnsemblBacteria" id="ABF89465">
        <property type="protein sequence ID" value="ABF89465"/>
        <property type="gene ID" value="MXAN_0024"/>
    </dbReference>
    <dbReference type="GeneID" id="41357533"/>
    <dbReference type="KEGG" id="mxa:MXAN_0024"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_3_7"/>
    <dbReference type="OMA" id="CFTNYLP"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="551"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="68607" checksum="E1E8AACF266CEEEC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVN2</accession>
    <name>Q1CVN2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557344.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7436"/>
    <dbReference type="TCDB" id="2.A.6.1.11">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86963">
        <property type="protein sequence ID" value="ABF86963"/>
        <property type="gene ID" value="MXAN_7436"/>
    </dbReference>
    <dbReference type="GeneID" id="41364585"/>
    <dbReference type="KEGG" id="mxa:MXAN_7436"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_14_0_7"/>
    <dbReference type="OMA" id="LWESAQQ"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187686" evidence="4">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="48546" checksum="F782F9A89A08AE8F" modified="2006-07-11" version="1">MRHFTAWGVLCLLMAGPARAVQADTPSPERLTQERTRSEATSPDLLTQEQRRSEVAPPEHITLEQALSLLDERSPWAAAERSRIDVAAADRVEASILPNPSFSYGTQLLAAGVNTGSSVVHELSLEQPLMIFGQRGVRRELAERNVSAEQARVKASLAERALAVREAFAALLTNQEELRVLEETAVDLGRVEKVVKGRAAAGDSSRYDVERIEVESRALEVEVLNARVNVADASGRLAALLGMEGWHPKAQGSLRTTESLPDLPLLWESAQQRRPSLVAARARQAVARGGLDVARRERLPVPSVAAGVMFTRNEQSTIALVGVGLPLPLFDRNQGAVARASAEMQAEARALEAELAEARAELSRAHAVLEGRKGALARLEHDVVERLPTVRRMAEDAYREGRGGILELLDAFRSLKDMRVLHLKQQETVKLAEASVLFAAGLDTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV5</accession>
    <name>Q1CVV5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7360"/>
    <dbReference type="EnsemblBacteria" id="ABF89540">
        <property type="protein sequence ID" value="ABF89540"/>
        <property type="gene ID" value="MXAN_7360"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7360"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789468_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187688" evidence="2">
        <location>
            <begin position="27"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="37372" checksum="41BDC51D73A5650A" modified="2006-07-11" version="1">MTSPLRPGWVLLSVLILLLSATTGCDDDPPPPIPDAGQQPTDSGTDAGSEDAGTDAGPEAPWDGGYTVLDDPGDWIDRGAFSACRFTVENPSLEACADPANFDMSSCNADQLAAVEQHGIYVGDGRSERRLADGARPSRRAPPPSSSSRMGVPTRSWAFPSPRGRRPAAPSSSPADSRIPTPESASSRWRAVRRPGPTSSPAAMSVARRRPGPPPGAWAPSRPSGRSGAAKPSRPAGCGSSPSSHLRVLDVTDPANIVKIGEHRMRYSTSIHNMILKGERLYVAWYHEGVRVLDVANPTQPRQVAHFNTFRETDPHRADGAFEGAIGIRVPGDGYVYVVDTSRGLLIFNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWM8</accession>
    <name>Q1CWM8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_7082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557001.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7082"/>
    <dbReference type="EnsemblBacteria" id="ABF92937">
        <property type="protein sequence ID" value="ABF92937"/>
        <property type="gene ID" value="MXAN_7082"/>
    </dbReference>
    <dbReference type="GeneID" id="41364257"/>
    <dbReference type="KEGG" id="mxa:MXAN_7082"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009368_0_0_7"/>
    <dbReference type="OMA" id="TERARMW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111366" checksum="1BD3350E389545CC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWN6</accession>
    <name>Q1CWN6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556993.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7074"/>
    <dbReference type="EnsemblBacteria" id="ABF88310">
        <property type="protein sequence ID" value="ABF88310"/>
        <property type="gene ID" value="MXAN_7074"/>
    </dbReference>
    <dbReference type="GeneID" id="41364249"/>
    <dbReference type="KEGG" id="mxa:MXAN_7074"/>
    <dbReference type="HOGENOM" id="CLU_1041433_0_0_7"/>
    <dbReference type="OrthoDB" id="1939183at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187855" evidence="1">
        <location>
            <begin position="35"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="29749" checksum="60BCF3B7C6F56022" modified="2006-07-11" version="1">MPRLAIVRAMPSLPDCRRLASLLTLVSSLLTAQAAEVSPAERVETSPGLSPDAVRRAFDSQRQTLTSCMRLVSIQRGKDKAPHSFEFVPWKAGPDTDDRIRVRFTLAPDGKVQKEERNTDAWGVRSLFLDTGCVEERVKTWSFPTFPGNHDERVQVELWARFRTTEAERTAAATRLREFYGDFCKALSALKVTQQPQAGVEWRATIKRFLAEHGARVDPRIGTAMQAVGDIAGHDVPGAISIYELSMEESLATTIPCPKLRAWVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ0</accession>
    <name>Q1CWQ0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">msrA</name>
        <name evidence="6" type="ORF">MXAN_7060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556979.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7060"/>
    <dbReference type="EnsemblBacteria" id="ABF85983">
        <property type="protein sequence ID" value="ABF85983"/>
        <property type="gene ID" value="MXAN_7060"/>
    </dbReference>
    <dbReference type="GeneID" id="41364235"/>
    <dbReference type="KEGG" id="mxa:MXAN_7060"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_3_7"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="49"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="23847" checksum="984BDD08654AE982" modified="2006-07-11" version="1">MFFNPTKKLRIPTPEEALPGRSDVMPVPEKHEVLGTPIKGPVPEGLEEVYFGLGCFWGAERKFYQTPGVYSTAVGYAGGPTPNPTYREVCSGLTGHNEVVRVVFDPKKVSFEQLLRVFWESHDPTQGMRQGNDVGTQYRSGIYFTSEAQQRAAVASRDAYQKALAARGFDAITTELLPAPPFYFAEDYHQQYLEKNPGGYCGLGGTGVSCPVGVGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR6</accession>
    <name>Q1CWR6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BNR/Asp-box repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556963.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7044"/>
    <dbReference type="EnsemblBacteria" id="ABF92360">
        <property type="protein sequence ID" value="ABF92360"/>
        <property type="gene ID" value="MXAN_7044"/>
    </dbReference>
    <dbReference type="GeneID" id="41364219"/>
    <dbReference type="KEGG" id="mxa:MXAN_7044"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616529_0_0_7"/>
    <dbReference type="OMA" id="CGSTWLH"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187718" evidence="2">
        <location>
            <begin position="29"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="47972" checksum="C250485C4001BB6D" modified="2006-07-11" version="1">MKSRITVAWSTVASLLAVLPGTAAHAHAGLPETSNVTLRRGHPQDFFSGTTFGAVISRDSGKTWRWVCPDAMGYGGWRPEAYLWRETGDILAATGSALLHSPDEGCSWRTHPFFKSTWVTGLAAHPTDDRVFHAVTGRPGIANGLYRSDDGGETWTASPLLRTGLELNAVRVSPVDPRRLYVSGVSNNQMVVLRSDDAGDTWQEFPHALPELLRPYALTVVAVDPVAVDVVWVRVSAQGYTHLLRSDDGGRTLTPVTVLDDTFINMDLSSDGGTAWVGTLNYFFMGSSTGPLEKQPLPTGNACVLRDGETLYGCGSTWLHDWALARSTDQGRTWEHIFALYEIQGTQLCPRGTPVRDLCPARWPQLAEQLGAPLYPDGGVEEPPPPDAGTPDAGTPDAGQQPPEQRPPEPKSGGCAAAAGPALPLLLLLSSLLPRRRGPRRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWV8</accession>
    <name>Q1CWV8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_7002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556921.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7002"/>
    <dbReference type="EnsemblBacteria" id="ABF92232">
        <property type="protein sequence ID" value="ABF92232"/>
        <property type="gene ID" value="MXAN_7002"/>
    </dbReference>
    <dbReference type="GeneID" id="41364178"/>
    <dbReference type="KEGG" id="mxa:MXAN_7002"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_63_7"/>
    <dbReference type="OMA" id="HEYESLH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="317"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="390"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="532"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="595"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="815" mass="89310" checksum="F9B4E2D6DD1DC3E1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWZ7</accession>
    <name>Q1CWZ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PBS lyase HEAT-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556882.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6961"/>
    <dbReference type="EnsemblBacteria" id="ABF92517">
        <property type="protein sequence ID" value="ABF92517"/>
        <property type="gene ID" value="MXAN_6961"/>
    </dbReference>
    <dbReference type="GeneID" id="41364139"/>
    <dbReference type="KEGG" id="mxa:MXAN_6961"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014447_0_0_7"/>
    <dbReference type="OMA" id="WVRYYAC"/>
    <dbReference type="OrthoDB" id="175446at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="788" mass="82168" checksum="435AC88F502A2413" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX21</accession>
    <name>Q1CX21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556858.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6938"/>
    <dbReference type="EnsemblBacteria" id="ABF90672">
        <property type="protein sequence ID" value="ABF90672"/>
        <property type="gene ID" value="MXAN_6938"/>
    </dbReference>
    <dbReference type="GeneID" id="41364119"/>
    <dbReference type="KEGG" id="mxa:MXAN_6938"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461399_0_0_7"/>
    <dbReference type="OMA" id="SHMLAIN"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="320"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="591" mass="62775" checksum="3D1B5314B81A34B6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX76</accession>
    <name>Q1CX76_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Transcription elongation factor, GreA/GreB family</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6882"/>
    <dbReference type="EnsemblBacteria" id="ABF90186">
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        <property type="gene ID" value="MXAN_6882"/>
    </dbReference>
    <dbReference type="GeneID" id="41364069"/>
    <dbReference type="KEGG" id="mxa:MXAN_6882"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_3_0_7"/>
    <dbReference type="OMA" id="NWGSPLG"/>
    <dbReference type="OrthoDB" id="1591985at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
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        <location>
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            <end position="164"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="18206" checksum="C1E0D79F8C698A4E" modified="2006-07-11" version="1">MSKAFTKEDSGDDSVMPVRPRASSGEKRYITPEGYRALQEELAAAQGPDPKAGEFTELEAGVRRKERERRVQELAAVLEDVRVVEPDASQAGRVFFGAWVELEDEDGGPVRYRIVGPDESDVKAGRLSVESPLARALLGKEVGESVVVDRPRGPVEYTVTAVDYAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX90</accession>
    <name>Q1CX90_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensory box histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6866"/>
    <dbReference type="EnsemblBacteria" id="ABF92097">
        <property type="protein sequence ID" value="ABF92097"/>
        <property type="gene ID" value="MXAN_6866"/>
    </dbReference>
    <dbReference type="GeneID" id="41364055"/>
    <dbReference type="KEGG" id="mxa:MXAN_6866"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433387_0_0_7"/>
    <dbReference type="OMA" id="TSVMGYA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="446"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="672" mass="72804" checksum="917C30B1D6ECAA8F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXD8</accession>
    <name>Q1CXD8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LPG_synthase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_6818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556743.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6818"/>
    <dbReference type="EnsemblBacteria" id="ABF86765">
        <property type="protein sequence ID" value="ABF86765"/>
        <property type="gene ID" value="MXAN_6818"/>
    </dbReference>
    <dbReference type="GeneID" id="41364007"/>
    <dbReference type="KEGG" id="mxa:MXAN_6818"/>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047543_0_0_7"/>
    <dbReference type="OMA" id="WLASRRM"/>
    <dbReference type="OrthoDB" id="715533at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="66"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="506" mass="55380" checksum="DAD4235C03776F4D" modified="2006-07-11" version="1">MLVVGEDLALITPAHASRVRERGAGPDRRCSRLRSTGWGAYLLPHVDGRSPEQPPAGPEPRERVLALLRRYGWNATSFQVLQPGFQYWFDPAGDACVAYVDTGGAWVAAGAPIAAPERLASVAEGFRVAARAVDRRVCFFATEPRFVELAPMASLPIGEQPVWDPVHWDDVVRGSRSLREQLRRARARGVKVREVPVTELGDPLHPTRRAVELLKARWLASRRMAPMGFLVQLRPHAFASERYAFVAEVEGEVVGFLSVSPVYAREGWFLQDLLRDPKAPNGTAEALVDAAMREAAATGRCYVTLGLAPLAGPVRPWLRLARACGRPLFDFEGLRTFKGKFRPDAWVPIHLSYPEPRGGLAAVYDALRAFAQGGLLRFGIATLLRRPRLLVHALAVLLVPWTALLALPSTARWFPSVQVQWAWVVFDVGLTVGLFSLVRRWRDALATVLGGLTAADACLTFVQAVAYNVPLARSPLDGALIALAVLAPATASGLLFSSRDLRLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ1</accession>
    <name>Q1CXJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556690.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6764"/>
    <dbReference type="ESTHER" id="myxxd-q1cxj1">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92410">
        <property type="protein sequence ID" value="ABF92410"/>
        <property type="gene ID" value="MXAN_6764"/>
    </dbReference>
    <dbReference type="GeneID" id="41363955"/>
    <dbReference type="KEGG" id="mxa:MXAN_6764"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076594_0_1_7"/>
    <dbReference type="OMA" id="DWYAEVD"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="16"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="29160" checksum="A25E5474D8E40BD4" modified="2006-07-11" version="1">MDPRKTAPFELGRGEEVCLLLHGFTGSPWDVRPLGEALAVRGLRVVAPRLPGHGTTPQALLDVTWRDWLAAAEHALHALRGHRSVFVAGLSMGALLALELAARHPEEIRALTLMAPAVRFRGPRMFLVRQLARTPVLEWTRPWVEKTGTDISDPEALAEAPVLPAFPVARLRDLCTLQTLAIRDAARVRCPTLVAVAEQDHVVAPEGGRWLARRLTAAPSVRVLSLRQGYHVIPRDTAGPLLAAEVGDFLAQQRSASWWESASPAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM9</accession>
    <name>Q1CXM9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter, EamA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6727"/>
    <dbReference type="EnsemblBacteria" id="ABF90172">
        <property type="protein sequence ID" value="ABF90172"/>
        <property type="gene ID" value="MXAN_6727"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6727"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_1_7"/>
    <dbReference type="OMA" id="AYGLFFY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="177"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="32432" checksum="38BDD003694B138D" modified="2006-07-11" version="1">MLASRAAPLPVSQPAPVSLPSGDVLPGGPQRGWLVASILSLYIIWGSTYLAIRWALEGGMPPFQMSGVRFVLAGALLFAVLWLRGAPVPTARQWGASALVGLLLLGVGNGGLVFAQQSVPSGVAALVVGSLPLWTALFGGLFGQWPRRAERWGLAVGFGGIVLLNLGGDVGGGLLPTLAMLVSPMSWALGSVWSRRLPMPRGLMSTAAQMLCGGVVMLGFSLLIGERPTAMPTPKAVLAFFYLVVFGSLVGYSAYGYLLRNARPSLATSYAYVNPVLAVFLGGLLAGETMTPTAWLAMGAILGAVVLLTRGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY73</accession>
    <name>RS14_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsN</name>
        <name type="synonym">rpsN2</name>
        <name type="ordered locus">MXAN_6528</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556458.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CY73"/>
    <dbReference type="SMR" id="Q1CY73"/>
    <dbReference type="STRING" id="246197.MXAN_6528"/>
    <dbReference type="EnsemblBacteria" id="ABF88355">
        <property type="protein sequence ID" value="ABF88355"/>
        <property type="gene ID" value="MXAN_6528"/>
    </dbReference>
    <dbReference type="GeneID" id="41363735"/>
    <dbReference type="KEGG" id="mxa:MXAN_6528"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_0_1_7"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000269054" description="30S ribosomal protein S14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="101" mass="11460" checksum="4BB8907FDA1A91CE" modified="2006-07-11" version="1">MAKKSKVARNAQRKALVAKYAKRRAALKARIRDRTLSYEERRAAQDALASLPRDSNPNRVTNRCALTGRPRGNLRRFGLSRIAFREKALRGEIPGVIKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYC2</accession>
    <name>Q1CYC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556409.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6479"/>
    <dbReference type="EnsemblBacteria" id="ABF87128">
        <property type="protein sequence ID" value="ABF87128"/>
        <property type="gene ID" value="MXAN_6479"/>
    </dbReference>
    <dbReference type="GeneID" id="41363686"/>
    <dbReference type="KEGG" id="mxa:MXAN_6479"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073078_1_0_7"/>
    <dbReference type="OMA" id="WPDMPLV"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="191"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32332" checksum="B804CD23353E237C" modified="2006-07-11" version="1">MPPRAAKTAHAPSPSAIKPTGLLLQPLFQMLLARPPELAPQAPWPDMPLVVWPTALAMWGPGDATTKHAHHAMHLVLCRQGTLSVRAQGMKTAEQAAGVLVGPDILHALDARDSEVIILFVEPESDDGARLQAALDGPIRLFETTQRDALLGGLPTAGALTHEAVGGWMESTLATLSGTPEAPRHLHPRVRKLLCHLRAEAAPEDTSLEALAQVAGLSPGRLMHTFTESVGVPLRPYLLWLRLQRAAGAIAAGHTLSEAAHAAGFSDAAHLTRTFRRMFGTTPSSLQRRGPRVQAQGRNGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYD3</accession>
    <name>Q1CYD3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556398.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6468"/>
    <dbReference type="EnsemblBacteria" id="ABF89071">
        <property type="protein sequence ID" value="ABF89071"/>
        <property type="gene ID" value="MXAN_6468"/>
    </dbReference>
    <dbReference type="GeneID" id="41363674"/>
    <dbReference type="KEGG" id="mxa:MXAN_6468"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_16_2_7"/>
    <dbReference type="OMA" id="RFMVRYP"/>
    <dbReference type="OrthoDB" id="1661500at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="33513" checksum="08D8B604C4FA7DC9" modified="2006-07-11" version="1">MPASPPLLDDMLLFTEVVATGGITAAAERLGLRKSTVSRRLAALEERLGVRLIERNTRGLRLTEVGRDYHAHCARLVAEAREVNRALGESRVTPQGTLRIATLSLLGELLTPLIAELLLRNPLLRVEVSLAEAHVDLISEEYDVALRTGPLADSAMVARRLGRLRTGYYASPAYLARQGAPRTSAELQGHACVVLAAPGTDEVWFFGEGRGAKSLPVTGRLRVPSVRAGQAAARAGLGVVRLPASLVAEDVRGGLLVPVLETETPPGIPVFAVYPSRRQLPLKVRAFLALLSERGAALPWDDATEPPSSRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI2</accession>
    <name>QUEC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name type="ordered locus">MXAN_6417</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556349.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CYI2"/>
    <dbReference type="SMR" id="Q1CYI2"/>
    <dbReference type="STRING" id="246197.MXAN_6417"/>
    <dbReference type="EnsemblBacteria" id="ABF87954">
        <property type="protein sequence ID" value="ABF87954"/>
        <property type="gene ID" value="MXAN_6417"/>
    </dbReference>
    <dbReference type="GeneID" id="41363627"/>
    <dbReference type="KEGG" id="mxa:MXAN_6417"/>
    <dbReference type="eggNOG" id="COG0603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_1_7"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="OrthoDB" id="1681374at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000255924" description="7-cyano-7-deazaguanine synthase">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <sequence length="230" mass="24413" checksum="0150E063ED6922C0" modified="2006-07-11" version="1">MVKRAVVLISGGLDSTTCLAMAKAKGFEPVCLAVAYGQRHAVELEQARKVAAAMGVTDFRVVSIDLRQVGGSALTADIEVPKDRPSDEMSHGIPVTYVPARNALFLSLALGLAEVVGSTDIYIGVNAVDYSGYPDCRPEFIRSFESMANLATKAGVEGAHFTVHAPLSGLTKADIIREGVKLGVDYGLTHSCYDPDAQGRACGRCDSCVLRKKGFEEAGVPDPTRYTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYJ1</accession>
    <name>Q1CYJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IPT/TIG domain/phospholipase D family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6408"/>
    <dbReference type="EnsemblBacteria" id="ABF87279">
        <property type="protein sequence ID" value="ABF87279"/>
        <property type="gene ID" value="MXAN_6408"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6408"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_258411_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1217"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1340" mass="140723" checksum="221B5E2E1123F39B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYW3</accession>
    <name>Q1CYW3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556221.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6283"/>
    <dbReference type="EnsemblBacteria" id="ABF90472">
        <property type="protein sequence ID" value="ABF90472"/>
        <property type="gene ID" value="MXAN_6283"/>
    </dbReference>
    <dbReference type="GeneID" id="41363503"/>
    <dbReference type="KEGG" id="mxa:MXAN_6283"/>
    <dbReference type="eggNOG" id="COG2342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543831_0_0_7"/>
    <dbReference type="OMA" id="QEDTWFG"/>
    <dbReference type="OrthoDB" id="288120at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016062">
        <property type="entry name" value="TM1410-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35882:SF1">
        <property type="entry name" value="PTHR35882:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01545">
        <property type="entry name" value="THEMAYE10DUF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188055" evidence="2">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="3">
        <location>
            <begin position="239"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="54097" checksum="2FD6A85B25B6A760" modified="2006-07-11" version="1">MRVAVVGWTSLWCIALFACGGASGSADSAERGEDTAVLAATRTLTCASLQVESGSIGSGQTVQGLHTQTLSGTQDRWAEYVEFFPGTLATCTYELPADVGAADVVAAEVGINYRGPLKSQMRWLFEAWDYTAGAWVLVSDNTFAQSWRWTATSLALTSPQRFVSGGPVQLRYRTTSTADASLLDLLVVRIQVAASDAGTPSDAGTPTDAGTPTDAGTSSDAGTGTEAGTPVSWEGVHSFTYQLTNYPQGKLDTIADSKFDLAIVELSRDGSDGWFTAAEITALKAKGKQVLAYFEIGAIEEYRPEWPQVPDDLKLGPVAGWPDEQYVKYWDERWWPIVQGRIDQALAAGFTGCYLDMVVTYEEIPANSAGTNRADLARKMVALIARISQYAKARNPAFKVMPQNSPELVDDPAYLPAIDGLGMEDMYWSDDNACDEGWCEENRTNAARVRAAGKLVLSTDYAIQAAHIADAYTRSRAAGFVPYVSVRALDRMTVNAGWDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYX9</accession>
    <name>Q1CYX9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase, FAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556207.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6265"/>
    <dbReference type="EnsemblBacteria" id="ABF90011">
        <property type="protein sequence ID" value="ABF90011"/>
        <property type="gene ID" value="MXAN_6265"/>
    </dbReference>
    <dbReference type="GeneID" id="41363488"/>
    <dbReference type="KEGG" id="mxa:MXAN_6265"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033626_0_0_7"/>
    <dbReference type="OMA" id="CRFIAFM"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="45488" checksum="A726AB5E06602B6E" modified="2006-07-11" version="1">MADEVRTTQCCVVGGGPAGMMLGLLLARAGVEVTVLEKHADFLRDFRGDTIHPSTLELMHELGWLDELLALPHQKAPVLRLQRGAHDVIVGDFSHLPTRARYIAFMPQWDLLDFLARKAAEYPGFHLRRCAEVTEVLREKGCVVGVQARTPEGSLEVRASLVVAADGRNSIMRQRAGLEVEVLGAPMDVLWFRVSRKPEDPEDPMGRFEQGQIFVLINRGDSWQCGRVIAKGSFDALREAGLVSFREDFARLAPFLADRAHELATWDDVKLLTVRVDRLRTWYQAGLLCIGDAAHAMSPVGGVGINLAVQDAVAAANILAGPLLARHVTPMDLRRVQERREWPTRVTQRAQVLIQNRVLGPALRSPAASTALPLPLWLVQHVPFLRRIPARLVGMGVRPEHVRTPAAPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZM8</accession>
    <name>Q1CZM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6010"/>
    <dbReference type="EnsemblBacteria" id="ABF91001">
        <property type="protein sequence ID" value="ABF91001"/>
        <property type="gene ID" value="MXAN_6010"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6010"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080971_0_0_7"/>
    <dbReference type="OMA" id="WVNITAV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011745">
        <property type="entry name" value="RNA_pol_sigma70_MYXXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03001">
        <property type="entry name" value="Sig-70_gmx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="33015" checksum="C9E4150A80174012" modified="2006-07-11" version="1">MVSGALGMHGANAEFFEWVLQAAGEPSSARLRAAPSAREAVDRAVSLAAALQAAAPESKAFAHHLGTLLSRAVDPVLSLERLHARDVALALSCAQGLPAARALLEQEVLLKLRVPLARIHPSPVFADEVLQALRANLLMPRAEAPSRLLGYAGAGPLLHWVSISATRLALRMRKALGEASHVEAEVLAEHPAPGGLELGFVREEARGHVRAAFVRAVASLDDEDRELLRLHFVERLSLERMGALFDLHKSTLSRRLTAVQSLLEKRTRRALAERLSLPEPEVDSVMRAIHGRLDLSLSGLLEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR8</accession>
    <name>Q1CZR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, S8 (Subtilisin) family</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555919.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5970"/>
    <dbReference type="EnsemblBacteria" id="ABF91307">
        <property type="protein sequence ID" value="ABF91307"/>
        <property type="gene ID" value="MXAN_5970"/>
    </dbReference>
    <dbReference type="GeneID" id="41363209"/>
    <dbReference type="KEGG" id="mxa:MXAN_5970"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364379_0_0_7"/>
    <dbReference type="OMA" id="CYSINFA"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188032" evidence="4">
        <location>
            <begin position="28"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="371"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="768" mass="82452" checksum="8C929BD74C136041" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZS0</accession>
    <name>Q1CZS0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_5968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5968"/>
    <dbReference type="EnsemblBacteria" id="ABF91142">
        <property type="protein sequence ID" value="ABF91142"/>
        <property type="gene ID" value="MXAN_5968"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5968"/>
    <dbReference type="eggNOG" id="COG4021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_3_1_7"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="BRENDA" id="2.7.7.79">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="PTHR12729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Thg1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1C" evidence="13">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF91142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="30359" checksum="BE7ABFE41648697D" modified="2006-07-11" version="1">MAFASNPGWRNPMDPDELAARARQGEVFHGQRMLPGAWVVLRVDGRGFSRFTEARYEKPFDPVFHQFMVRTASVMLEELQGVYAYTQSDEISVLFRPDWALFDRSVEKVVSLAAGLASATFTHAAGVPAVFDGRAWLGASERAVLDYFIWRQADGSRCSLHGWCYWTLRKEGRSAAQATRELDGKPVSYKNELLFQRGINFNDVPLWQRRGSGVWWEAYQKEGVDPRDGRRTQTLRRRLKVDSELPMKEAYEHLVRGLLAAPGAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZU0</accession>
    <name>Q1CZU0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c family protein/iron permease, FTR1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_5946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555897.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5946"/>
    <dbReference type="EnsemblBacteria" id="ABF86977">
        <property type="protein sequence ID" value="ABF86977"/>
        <property type="gene ID" value="MXAN_5946"/>
    </dbReference>
    <dbReference type="GeneID" id="41363185"/>
    <dbReference type="KEGG" id="mxa:MXAN_5946"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027143_0_0_7"/>
    <dbReference type="OMA" id="MHDRRHA"/>
    <dbReference type="OrthoDB" id="433945at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187939" evidence="11">
        <location>
            <begin position="22"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF86977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="617" mass="65975" checksum="A0323E76CBFE8397" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D057</accession>
    <name>Q1D057_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23 peptidase domain protein</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555780.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5829"/>
    <dbReference type="EnsemblBacteria" id="ABF87757">
        <property type="protein sequence ID" value="ABF87757"/>
        <property type="gene ID" value="MXAN_5829"/>
    </dbReference>
    <dbReference type="GeneID" id="41363069"/>
    <dbReference type="KEGG" id="mxa:MXAN_5829"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026846_4_0_7"/>
    <dbReference type="OMA" id="GPHVCYR"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="281"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="423" mass="46153" checksum="106100A64F97DFC5" modified="2006-07-11" version="1">MASSSQAAEPGNFPALRWASARVSTTLGRRPMRIAPLLCLAAALLASTSEAAVRHVIKNRRIEPRQTLAQALHDAQLPDAQVAAVISALEGVFDFRKSRVGDQLRLVIRDGELDFFDYRQSMVDEWQVRRDGEKYVGSKRAIEVEKQVAVVALEIQSSLYEAAVAAGEDPAIGMVLADVFAWDIDFYRDVRKGDTARALVEKFVSKGRLLRYGDVLAATYAGGLVGNKKVYRYVLPDGQPNYFNEEGASAKKTFLKTPLKYANVTSRFGSRFHPVLKYLKAHNGVDYGTPIGTPVWAVADGTVTQAGYAGAAGNMVVIRHANGFETQYMHLSRFGEGVRAGARVRQKQVIAYSGNTGRSTGPHLHFGLKRNGQYTNPLNQQFPRADPLPKELLPDFLAKAQELTGQMEAVSVAAVAGQAAAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0I6</accession>
    <name>Q1D0I6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555651.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5699"/>
    <dbReference type="EnsemblBacteria" id="ABF85972">
        <property type="protein sequence ID" value="ABF85972"/>
        <property type="gene ID" value="MXAN_5699"/>
    </dbReference>
    <dbReference type="GeneID" id="41362944"/>
    <dbReference type="KEGG" id="mxa:MXAN_5699"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="FNWPGHP"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF85972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="233" mass="24605" checksum="C42C453DF8C4BA16" modified="2006-07-11" version="1">MIQARDVVKTYVDGDGTPVCVLDGMSLDVTQGEFVAVVGSSGSGKSTLLHLLGGLDVDYRGDISVGGVKLRGLGDKALAHFRNTHVGFVFQSFHLIPNLSAVENVLLPSHFGVAPPDARKRAEALLERVGLGAKKDRAPVRLSGGERQRVAIARALFGKPRLLLCDEPTGNLDAATGTGVIALFQELHREGLTVLCVTHEERMSAAAGRVLRLKDGQLVEERAGLQVATGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N9</accession>
    <name>Q1D0N9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bacterial export protein, FliR/MopE/SpaR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555599.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5645"/>
    <dbReference type="EnsemblBacteria" id="ABF86995">
        <property type="protein sequence ID" value="ABF86995"/>
        <property type="gene ID" value="MXAN_5645"/>
    </dbReference>
    <dbReference type="GeneID" id="41362891"/>
    <dbReference type="KEGG" id="mxa:MXAN_5645"/>
    <dbReference type="eggNOG" id="COG4791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053044_0_0_7"/>
    <dbReference type="OMA" id="PFWLFES"/>
    <dbReference type="OrthoDB" id="1284524at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="26755" checksum="579EB6369F044994" modified="2006-07-11" version="1">MNLEPLRAWLESLGPDIIVVALCAARLLPMTFLCPLLGGQATPTMVRLALVLSLSLFLRVEAGVVLDAPVTSAVALGGLVIRELLFGTSVGLVAALPFDAARMGGRFIDLLRGTSAEASLPLAGSRESAAGEGLYHLLVALVVSGGMWPLVISSVLRGFGVVKLGAFVPTEAATLHVVLLAGAAMATGLAVGAPIAAAVLTVDCFLGLASRAAPQVNLQEVGTPLKILGGGALLWLGTGVLCERLLAGVLSVEGALALLGEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q1</accession>
    <name>Q1D0Q1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555587.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5633"/>
    <dbReference type="EnsemblBacteria" id="ABF88990">
        <property type="protein sequence ID" value="ABF88990"/>
        <property type="gene ID" value="MXAN_5633"/>
    </dbReference>
    <dbReference type="GeneID" id="41362879"/>
    <dbReference type="KEGG" id="mxa:MXAN_5633"/>
    <dbReference type="HOGENOM" id="CLU_1755040_0_0_7"/>
    <dbReference type="OMA" id="WLTEQML"/>
    <dbReference type="OrthoDB" id="1591943at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="152" mass="17719" checksum="9F06F9ED31108615" modified="2006-07-11" version="1">MASRWDHLFDLKPTSLLEHLLEEVAKLLHKDLLQWPPPVEELDLDTGGHFATLFTEPRPRPSRAVYTEAFRLAQWELARETDAYDDYMRNKRYLERGLVPSDRLPLLLLSRWLTEQMLGLGEATEGRVKRKHMRDCLERLQSKLGAFPVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T8</accession>
    <name>Q1D0T8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5596"/>
    <dbReference type="EnsemblBacteria" id="ABF88500">
        <property type="protein sequence ID" value="ABF88500"/>
        <property type="gene ID" value="MXAN_5596"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5596"/>
    <dbReference type="HOGENOM" id="CLU_2106325_0_0_7"/>
    <dbReference type="OMA" id="IFTRQGA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="14215" checksum="DFA2BC2B5605C4EA" modified="2006-07-11" version="1">MFPVTPPTSSSPGGVVNLHHARRAKRLDLYRGRHTDRVRFVRTTLETLTQSGTLFTEEGTRRGLSLLKALQLLQRAHARLEEVSGDGVLPAARLPERVDALYSEVDGLFARADTLSARDEASVAQLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D144</accession>
    <name>Q1D144_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555444.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5486"/>
    <dbReference type="EnsemblBacteria" id="ABF89986">
        <property type="protein sequence ID" value="ABF89986"/>
        <property type="gene ID" value="MXAN_5486"/>
    </dbReference>
    <dbReference type="GeneID" id="41362740"/>
    <dbReference type="KEGG" id="mxa:MXAN_5486"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067817_1_0_7"/>
    <dbReference type="OMA" id="FIIDPLY"/>
    <dbReference type="OrthoDB" id="903022at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="36138" checksum="66FA11950FF00C4C" modified="2006-07-11" version="1">MDNLTHGLLGLAIGAMRKPDVRPGAPERASPTDRAVLVASVLAAELPDLDTLLARGDAVTVALQAHRGLSHALVAAPLVALTATLAARALFRGARLAPVFLTSLASVVFAHLLPDLWTGWGTRVLLPFSDSRLSLDWTMVVDPWVTLPLLAGAILAWRRRADWRRTLLWSAACSVAYVGFRVATWAVLTQRVEAAYPAAQAVRVFPLPFSVSTWRYVATLPGDVFAAGEVPLAGPPSEARRAEATGSTLPEHVQAVPTVREALAWARFPLVHMEPLAEGGQKVRIADLRYHLRGEPTLAFVIHLDASNAVTHAQLERGGSASELLRKWRSADTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B3</accession>
    <name>Q1D1B3_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89877">
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        <property type="gene ID" value="MXAN_5413"/>
    </dbReference>
    <dbReference type="GeneID" id="41362676"/>
    <dbReference type="KEGG" id="mxa:MXAN_5413"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490763_0_0_7"/>
    <dbReference type="OrthoDB" id="659323at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188146" evidence="1">
        <location>
            <begin position="23"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="555" mass="59752" checksum="EB434FF71342301E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1P4</accession>
    <name>Q1D1P4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3943 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5277"/>
    <dbReference type="EnsemblBacteria" id="ABF85994">
        <property type="protein sequence ID" value="ABF85994"/>
        <property type="gene ID" value="MXAN_5277"/>
    </dbReference>
    <dbReference type="GeneID" id="41362554"/>
    <dbReference type="KEGG" id="mxa:MXAN_5277"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039377_0_0_7"/>
    <dbReference type="OMA" id="WETSPEV"/>
    <dbReference type="OrthoDB" id="1819690at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025079">
        <property type="entry name" value="DUF3943"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13084">
        <property type="entry name" value="DUF3943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188023" description="DUF3943 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3943" evidence="2">
        <location>
            <begin position="115"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="496" mass="53158" checksum="A03824D568597869" modified="2006-07-11" version="1">MHAMNSLPVHRVSGLLLVFALVSGGDAGAAPADAPLASKECVEAVPAEPRLLVPELVHPPRRAIWNAPDGGGRNFVVPIVEMGAFHAIFWGTAKLLGKPYADISLETMRRNVADGWEWDEDAFATNALGHPYQGSLAYTAARSSGFGFWGSVPFTVASSVLWELFMESETPSTNDLITTSIGGVVLGEVLHRTALAILDEGEPTVARSVLSLLVEPVGGINRYLFGRRKNDFLPVQGNFLQLMAGFTSNVDNYNDIDGTRFDVPNKMEGHLGVEMVYGPPLLTTGDYDQPFDYFTLTARMGFSRDTLTVGFFSRGLLYGDRFKFRSISGLWGLMAGYDFANPNTLRVSTVSLGIGGVAQVPLTSQLTLDVTANMAGVPFGHGGGLTSPESARDYHFGPGAQSAFELGLVRRGVGRVGVSVRNYLISGAFLGEGVELITYATARAELLLAGQHGVALEAFVANRAGEFGSDSDAIRQRATQIRLLWTVSKGTGFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1P5</accession>
    <name>Q1D1P5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_5276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5276"/>
    <dbReference type="EnsemblBacteria" id="ABF92247">
        <property type="protein sequence ID" value="ABF92247"/>
        <property type="gene ID" value="MXAN_5276"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5276"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_7"/>
    <dbReference type="OMA" id="EPGSMTA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="586" mass="63889" checksum="F3E55B9B38E5C22B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R5</accession>
    <name>Q1D1R5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5256"/>
    <dbReference type="EnsemblBacteria" id="ABF86705">
        <property type="protein sequence ID" value="ABF86705"/>
        <property type="gene ID" value="MXAN_5256"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5256"/>
    <dbReference type="eggNOG" id="ENOG5030RGD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056997_0_0_7"/>
    <dbReference type="OMA" id="REEGFLM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="33078" checksum="7184BB7CE81AAAC4" modified="2006-07-11" version="1">MSSPSSVPARPGPGRHARFLCSRFGKRLTQEQNPGRMARMHMSALLMVALLAAPAQPLTWKVTGADVTFEMSAKDLRALRDGKEVFGLQSRQADFLSNFKAEEGTNTFGWEGSQSLKVLSVVGPWVSYENSDSGFTGGAHPYASTSYVTEDVTKPKGAFSLLSVFPEKDVVAALKADRFIRKHIHDEAAFKDARTVDALMQSLEPGEDCVGFDSGGLESVKRSVAFHHIEGNKVAVRISFGYAAEACRGRSFVVGVLLTISAELRPALKRAARREEGFLMKDAKAVKAPSVHFTWESPEPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T0</accession>
    <name>Q1D1T0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555208.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5241"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91286">
        <property type="protein sequence ID" value="ABF91286"/>
        <property type="gene ID" value="MXAN_5241"/>
    </dbReference>
    <dbReference type="GeneID" id="41362520"/>
    <dbReference type="KEGG" id="mxa:MXAN_5241"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1298058_0_0_7"/>
    <dbReference type="OMA" id="YRIRPND"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="22764" checksum="4D34C6EFBCB64C68" modified="2006-07-11" version="1">MGVGASMSNYRIRPNDTLSGLAARFGTTVEKLARDNNITNPDLIYAGNTLRIGHSGRDSFDAGGGRQGVRGGGPSGGVSGGADVGGPTGAGPSNASDAMRRLADAARSAAMGMGGYNSQGLCATGVSRAIRNSLGIGVSGNGNQIDNNLPRDKFKQVNMSLEEALKIPGLVLTWESTSTRLGSIYGHTAVTLGDGHSSASDFIERNTTNSGRTGFKVFMPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T7</accession>
    <name>Q1D1T7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5234"/>
    <dbReference type="EnsemblBacteria" id="ABF85960">
        <property type="protein sequence ID" value="ABF85960"/>
        <property type="gene ID" value="MXAN_5234"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5234"/>
    <dbReference type="eggNOG" id="ENOG5033KE5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1446226_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="19273" checksum="2EEF77ECB9926AD5" modified="2006-07-11" version="1">MADSPSSSWQRGTELLKRAACLYDAPGSVLADEARGAWRTGFTGGAAWMANGLALVRGQPAATVPPNVGRWGALKYGGALLSAGVAGGFASGLGAPLAVALVVAGLAFYAAEAQGLFLFPLLLDGTEHPWRSGRALLRRAGGTPSAMGTVLMLAGVMLLGGVVGRGWLRCWCLGCLAVVLWYEDLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U4</accession>
    <name>Q1D1U4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89267">
        <property type="protein sequence ID" value="ABF89267"/>
        <property type="gene ID" value="MXAN_5227"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5227"/>
    <dbReference type="HOGENOM" id="CLU_2917806_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="61" mass="6582" checksum="396BF5B632BACCC9" modified="2006-07-11" version="1">MHVAHEAGDAVGIVAREFSQRSCGLFCDVQIALDEALRHTYVADSTWALCTRGTYGALGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D211</accession>
    <name>Q1D211_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555130.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5159"/>
    <dbReference type="EnsemblBacteria" id="ABF86822">
        <property type="protein sequence ID" value="ABF86822"/>
        <property type="gene ID" value="MXAN_5159"/>
    </dbReference>
    <dbReference type="GeneID" id="41362441"/>
    <dbReference type="KEGG" id="mxa:MXAN_5159"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_0_7"/>
    <dbReference type="OMA" id="HRNDRLP"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="504" mass="54821" checksum="79E592D8BE33C61E" modified="2006-07-11" version="1">MSTGSILGIDFGTTNTAAAFFDKAGKLRVVPVTDKSVTLPSVVWFHAADKAIVGHAARRQIIDDPRHTVFGAKRFLGRRFQSEYVTQHKDKYAFGLVEAEDGYTAVTMYGKQTSLTDVAHLIIKQIHTLANHAAGTPFRECVLTVPAHASSRQRAAVRHAAEQAGLQVRAIINEPTAAALYYANLRNPEQTVMVFDLGGGTFDATLLAVQNKVVKVLATGGDAFLGGANFDERIVEMLVNDFQQKHGIDLRGNKVVMQRLVFAAESAKMALSQRDATVLRVPCIAQKDGGFIDFDYTLTRKRLEEMAFQLIERTASACDDVLERAKLKADQIDELVLVGGQTRMPAIRQRFSHFKRMSSDKEVNPELGVAVGAAILGRNLARGITGLADVVPMPISIMVPGGAQHEVIPANTPVPATKSVTMELPMIPGPLSIALFEALDTTTVDRELLGTVRVELDWRTTYKGPTTLELRMGQDFVLSAALVSPQGARHPLAISDMRAPKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2G4</accession>
    <name>Q1D2G4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5003"/>
    <dbReference type="EnsemblBacteria" id="ABF89259">
        <property type="protein sequence ID" value="ABF89259"/>
        <property type="gene ID" value="MXAN_5003"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5003"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_1_7"/>
    <dbReference type="OMA" id="GYQYGMA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="12404" checksum="50592EA71B38C189" modified="2006-07-11" version="1">MAKPPKGITIADSAVARLKELLEQRQTPEAGLRLAVKGGGCSGLQYSMEWSEKSRERDKIFEKDGVRVFVDPKSYLYLIGTELVFEQTLMASGFKLDNPNIKAACGCGESFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2H5</accession>
    <name>Q1D2H5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554970.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4992"/>
    <dbReference type="EnsemblBacteria" id="ABF89704">
        <property type="protein sequence ID" value="ABF89704"/>
        <property type="gene ID" value="MXAN_4992"/>
    </dbReference>
    <dbReference type="GeneID" id="41362276"/>
    <dbReference type="KEGG" id="mxa:MXAN_4992"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_7_0_7"/>
    <dbReference type="OMA" id="LIAWCRT"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26910" checksum="6D071C6A45989008" modified="2006-07-11" version="1">MARVDRVMRLLDFLRGRDGTTVAEISEALEVSARTVHRDLATLREQGIPLSSDTGPGGGVRLERDRGVAAVHLSQEEVVALWLAANLSATGSTLPWGGAARSGLQKLFASVPKERARGMRELCRRVVVGRPASARVLKDVGTPPEELLAVFERAFREQVCLSFEYRDRHGKATRRIVEPHGLLVESPVWYVLARDVEKAAARMFRMDRIRRARLVPDRPFTPDMEGLRAQADAQRANGTRAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L8</accession>
    <name>Q1D2L8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554927.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4949"/>
    <dbReference type="EnsemblBacteria" id="ABF89034">
        <property type="protein sequence ID" value="ABF89034"/>
        <property type="gene ID" value="MXAN_4949"/>
    </dbReference>
    <dbReference type="GeneID" id="41362234"/>
    <dbReference type="KEGG" id="mxa:MXAN_4949"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_7"/>
    <dbReference type="OMA" id="TEGLAEW"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23839" checksum="AA9045E2D04DB04D" modified="2006-07-11" version="1">METVASTGPVAGGPLRGSGGQVGASEGLTEWVRRAAHGEASAYSEIYRRTRPLVTRLVGGFAQLDSDEVEDVIQETFVRAFRALPRLKEPGAFESWLLSIARNRARTRLERKSSTRRLEEDVADPDPESVPHIPEALQLERDIAVVRRLIAELPEGEEKRTVHLFYVEGELSAREIAEKLGVGKSAVTMRLERFRSRIKRELLRRVLAGRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2P6</accession>
    <name>Q1D2P6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4921"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93053">
        <property type="protein sequence ID" value="ABF93053"/>
        <property type="gene ID" value="MXAN_4921"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4921"/>
    <dbReference type="HOGENOM" id="CLU_672369_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="277"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="409" mass="43624" checksum="636A825E68A12178" modified="2006-07-11" version="1">MGARFHLEAGRCCVTGGCNCVPAAARFGVQVWSATVYRLRERGEQGAHSLRNLGLGGFLTPAPNGSEARPVPSPERLHSMLPSLSRSGLPIWTLVLAMLLCGTANAQFTGKRRAYASSFWGGTGASGKTISWSALYVALPLDYGYNAANNTIVNLAGVTAAQSDLRTSSTRSLKWGTQIRITNRHPGHAGYGRSVLTTLQDSGPADSILSDAALGGRAASPYKPLGCWIDVTPGVKQALGSTKPETENLIVDFEVVNDLGSSLDLDSNPNLAFGMAASASDSENTGISAPIAAVDGNGAYHLENYRSAWRSAYHANTSDTVWLNVNLGRAEAVRRVVVKWGSFVPPGYTLMGWTPGMSSWVTLATRTGAGGGTHVHSFTSDQTYQYFGLSMSGATRYDVKELEVYRWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R5</accession>
    <name>Q1D2R5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">smc</name>
        <name evidence="6" type="ORF">MXAN_4901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554882.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4901"/>
    <dbReference type="EnsemblBacteria" id="ABF86378">
        <property type="protein sequence ID" value="ABF86378"/>
        <property type="gene ID" value="MXAN_4901"/>
    </dbReference>
    <dbReference type="GeneID" id="41362191"/>
    <dbReference type="KEGG" id="mxa:MXAN_4901"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_7"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="528"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="252"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1200" mass="133397" checksum="86612C756BA324E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2W0</accession>
    <name>Q1D2W0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ffh</name>
        <name evidence="10" type="ORF">MXAN_4854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554838.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4854"/>
    <dbReference type="EnsemblBacteria" id="ABF92485">
        <property type="protein sequence ID" value="ABF92485"/>
        <property type="gene ID" value="MXAN_4854"/>
    </dbReference>
    <dbReference type="GeneID" id="41362149"/>
    <dbReference type="KEGG" id="mxa:MXAN_4854"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_7"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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            <end position="534"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90383.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="557" mass="58874" checksum="FFEF0E2172271C41" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D371</accession>
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        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">MXAN_4740</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="705"/>
        </location>
    </feature>
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        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="746" mass="79755" checksum="EADEA4682BC21084" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3I2</accession>
    <name>Q1D3I2_MYXXD</name>
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        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbA</name>
        <name evidence="8" type="ORF">MXAN_4623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
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    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="TCDB" id="3.A.1.103.4">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
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    <dbReference type="EnsemblBacteria" id="ABF87385">
        <property type="protein sequence ID" value="ABF87385"/>
        <property type="gene ID" value="MXAN_4623"/>
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    <dbReference type="GeneID" id="41361923"/>
    <dbReference type="KEGG" id="mxa:MXAN_4623"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0043190">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0055085">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC_2_trans"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_TM2"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
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        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="15"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="29688" checksum="1C4D98F6EDB8BDDD" modified="2006-07-11" version="1">MIRLVRELYQYRGLLISLVQRELKARYRGSFLGFLWTFLNPTLHMLVYVLLFTVVMRQNIPNFPFFMFVGLLPWIWFSTSVGGGASAISDRRDLLTKVRFPAQVLPTSVVVTNLCNFVLSLPLMLVLGMAYGQWPTWHVVLFPVVVLIQLTFTLALTYILAAINVTFRDLQHIVSNLLTLWFFATPVLYPLSTIQDESARSLMLALNPMVSLMTSYQAIFYEHRLPDAEPLMALAAVSVVLLWAASSIFESRREEFAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Q8</accession>
    <name>Q1D3Q8_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Putative molybdenum cofactor carrier protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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        <property type="entry name" value="LDcluster4"/>
    </dbReference>
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        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19884" checksum="B85897B485E7B258" modified="2006-07-11" version="1">MRRPRRIIGVFGSGKEDHAERVIPLVRWIAEAGFDLLTGAGSGVMRTAADAFVQVAYRHGISIGIVPGTVEGGEYRPRSGYPNPNVELPIYTHLPLSGEQGTEPLSRNHINVLTPHALVSLPGGAGTVAEAVLALRYGKPVILYGPPESFRRFPAELERTDSLERVAEFLRAAVRDPLRLAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4I2</accession>
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        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Acta Crystallogr. F Struct. Biol. Commun." volume="72" first="652" last="658">
            <title>Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.</title>
            <authorList>
                <person name="Bock T."/>
                <person name="Muller R."/>
                <person name="Blankenfeldt W."/>
            </authorList>
            <dbReference type="PubMed" id="27487931"/>
            <dbReference type="DOI" id="10.1107/S2053230X16011146"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554269.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="5K1S">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.55 A"/>
        <property type="chains" value="A/B/C/D=1-345"/>
    </dbReference>
    <dbReference type="PDBsum" id="5K1S"/>
    <dbReference type="SMR" id="Q1D4I2"/>
    <dbReference type="STRING" id="246197.MXAN_4266"/>
    <dbReference type="EnsemblBacteria" id="ABF87438">
        <property type="protein sequence ID" value="ABF87438"/>
        <property type="gene ID" value="MXAN_4266"/>
    </dbReference>
    <dbReference type="GeneID" id="41361581"/>
    <dbReference type="KEGG" id="mxa:MXAN_4266"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_7"/>
    <dbReference type="OMA" id="GAWAEYT"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5K1S"/>
        </source>
    </evidence>
    <sequence length="345" mass="36106" checksum="E53BA7D6437CF5CD" modified="2006-07-11" version="1">MKAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAILGHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGDCALCRSGRNSLCKTDNRFFGEELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGASGGVGLSSVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQGAGVDVAVEIVGSATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEALRLTATGGVRQFVTDAVPLAEAAKAHFRLENREVAGRLVLVPPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4I8</accession>
    <name>Q1D4I8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4260"/>
    <dbReference type="EnsemblBacteria" id="ABF92844">
        <property type="protein sequence ID" value="ABF92844"/>
        <property type="gene ID" value="MXAN_4260"/>
    </dbReference>
    <dbReference type="GeneID" id="41361575"/>
    <dbReference type="KEGG" id="mxa:MXAN_4260"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1863026_0_0_7"/>
    <dbReference type="OMA" id="GARDCFA"/>
    <dbReference type="OrthoDB" id="1970564at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="14243" checksum="3620B078766F3A46" modified="2006-07-11" version="1">MKSSSIARALLLGGDASLSSLLMDVLAELGIALESGAPAGGCPDLVLVHVERGESLQRRLQRARELSPQGPIIVLLPFADERLMGLALRLGARDCFALGGPLGELRRVLLAHVPGHPSSVFISPGGAVPPSTESPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K4</accession>
    <name>Q1D5K4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553899.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3889"/>
    <dbReference type="EnsemblBacteria" id="ABF89404">
        <property type="protein sequence ID" value="ABF89404"/>
        <property type="gene ID" value="MXAN_3889"/>
    </dbReference>
    <dbReference type="GeneID" id="41361222"/>
    <dbReference type="KEGG" id="mxa:MXAN_3889"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_534975_0_0_7"/>
    <dbReference type="OMA" id="WAERIDE"/>
    <dbReference type="OrthoDB" id="614318at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="550" mass="60172" checksum="12EEE58021D3873B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5N0</accession>
    <name>Q1D5N0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Monovalent cation/proton antiporter, MrpF/PhaF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553873.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3863"/>
    <dbReference type="EnsemblBacteria" id="ABF90297">
        <property type="protein sequence ID" value="ABF90297"/>
        <property type="gene ID" value="MXAN_3863"/>
    </dbReference>
    <dbReference type="GeneID" id="41361196"/>
    <dbReference type="KEGG" id="mxa:MXAN_3863"/>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_1_2_7"/>
    <dbReference type="OMA" id="YERAIYI"/>
    <dbReference type="OrthoDB" id="2083248at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028784">
        <property type="entry name" value="MrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="93" mass="10037" checksum="446B76325EC328D2" modified="2006-07-11" version="1">MSDWLQTITQGALGAISVSMLFSLHRLLRGPSLTDRVVALDLFSLQTSAVITVYALWMGQPELVDVALVLAVIGSMGTIVIARYLYSAQRGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Y7</accession>
    <name>Q1D5Y7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553767.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3754"/>
    <dbReference type="EnsemblBacteria" id="ABF87204">
        <property type="protein sequence ID" value="ABF87204"/>
        <property type="gene ID" value="MXAN_3754"/>
    </dbReference>
    <dbReference type="GeneID" id="41361087"/>
    <dbReference type="KEGG" id="mxa:MXAN_3754"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030800_0_0_7"/>
    <dbReference type="OMA" id="KMHEIAD"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="225"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="519" mass="55469" checksum="9DA6298EFE097991" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D620</accession>
    <name>Q1D620_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553734.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3717"/>
    <dbReference type="EnsemblBacteria" id="ABF91322">
        <property type="protein sequence ID" value="ABF91322"/>
        <property type="gene ID" value="MXAN_3717"/>
    </dbReference>
    <dbReference type="GeneID" id="41361050"/>
    <dbReference type="KEGG" id="mxa:MXAN_3717"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_7"/>
    <dbReference type="OMA" id="NYLVFPK"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="28712" checksum="C3921DC5876C2D58" modified="2006-07-11" version="1">MTTQTPSKPAREPGPFTQAVTRFGQGLIDIVSTLGGIITMGLDVFRWSVRRPFRLVNLFAQLDFVGVGSIFIVSLTGTFTGMVFALQTSTAFQLFDAESLVGPTVALTLTRELAAVFSALMVTMRAGSAMCTELGTMRVTEQVDALETMAVNPVQYLLVPRVLAGLFMVPALTMLFNTMGMGGAYVVAVGGLGISPGTFLSRTQQWLAPEDIFQGLLKGAVFGLSVSLICCFKGFNASGGAKGVGQATTEAMVASALSIFILDFILGILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D635</accession>
    <name>Q1D635_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3702"/>
    <dbReference type="EnsemblBacteria" id="ABF87865">
        <property type="protein sequence ID" value="ABF87865"/>
        <property type="gene ID" value="MXAN_3702"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3702"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_0_7"/>
    <dbReference type="OMA" id="MKHFAIF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="19400" checksum="2CA54D8E5AE81891" modified="2006-07-11" version="1">MARTRGDFEGFLMSNSHSHHHDDHDKDEGLARYMAQHGLKSTRQRSLIIDTFFAVGGHLSVEELWNKVREQDTKVSVATVYRTMKLLSECGLAHARNFGDGQTRYEAAAGRDHHDHLVCTRCGTIIEFENERIEALQDAVARKHGFKVTSHKMELYGLCRDCQRAGSAASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D9</accession>
    <name>Q1D6D9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ORF">MXAN_3595</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3595"/>
    <dbReference type="EnsemblBacteria" id="ABF90115">
        <property type="protein sequence ID" value="ABF90115"/>
        <property type="gene ID" value="MXAN_3595"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3595"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_7"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="50"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="413"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="721"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABF90115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="815" mass="87579" checksum="AD8703180FB00556" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6R1</accession>
    <name>HUTH_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
            <shortName evidence="1">Histidase</shortName>
            <ecNumber evidence="1">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutH</name>
        <name type="ordered locus">MXAN_3465</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553498.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6R1"/>
    <dbReference type="SMR" id="Q1D6R1"/>
    <dbReference type="STRING" id="246197.MXAN_3465"/>
    <dbReference type="EnsemblBacteria" id="ABF90953">
        <property type="protein sequence ID" value="ABF90953"/>
        <property type="gene ID" value="MXAN_3465"/>
    </dbReference>
    <dbReference type="GeneID" id="41360812"/>
    <dbReference type="KEGG" id="mxa:MXAN_3465"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_7"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000021561" description="Histidine ammonia-lyase">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="1">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <sequence length="508" mass="54180" checksum="4BAB70B9CB38B5B9" modified="2006-07-11" version="1">MSRPRILIDGDTLKLEEILQVARNEATVELSPDAATRVRASRALVDRVAAGDTPAYGINTGFGTLAEVRIDKKDLRDLQRNLILSHACGVGTPLPLPEARALLLLRCNVLAKGYSGIRMETLALALDMLNRDVVPVVPERGSVGASGDLAPLAHLALVFIGEGEAFYQGQRMPAKQALERAGLQPVVLEAKEGLALVNGTQAMCAVGTLLQLRAESLADIADVAGAMTLEGLLGSHKPFIPEIHDVRAHPGQKDVAAHLRRILVDSELVESHVNCSKVQDPYSLRCMPQVHGAAREGIAFSRRILEVEVNSATDNPLVFADTERIVSGGNFHGQPISLAMDVVAMALTQLSSISERRVEQLVNPSLSNLPAFLAKNSGLNSGFMIAQVTSAALVAESRVLSHPASVDSIPSSAGREDHVSMGMTAALKGRQVSDFARSCLAIEILVAAQALDFRLPLKPGKGALAAYELVRSKVPHMDKDRELHRDIEAVSQLVDSGELLAAVRSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S5</accession>
    <name>Q1D6S5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553484.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D6S5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3451"/>
    <dbReference type="EnsemblBacteria" id="ABF90211">
        <property type="protein sequence ID" value="ABF90211"/>
        <property type="gene ID" value="MXAN_3451"/>
    </dbReference>
    <dbReference type="GeneID" id="41360799"/>
    <dbReference type="KEGG" id="mxa:MXAN_3451"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_7"/>
    <dbReference type="OMA" id="DREPIDI"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="183"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="244"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="452" mass="48699" checksum="E1F04CF990E44004" modified="2006-07-11" version="1">MRLVRRMWLWGAVVPVVAVVAALGVAVQVFRVVLERTLDEALLSQAAAESVSLFDAPDGRPHLHVEPSPLAGEVRAFVPATRLYGPDGTLLSVFPPESPTVYERVLPEDGPTSRLETQRLGSGLRLRVLTVQVRSPKGVPHVLQLVASLGTVDQAVGTFTSVATVLALLLGGVLIGIQGWQARGLARRLHGIADQVARSRDGGMVAPVPVDEPRDEIMEVRLALTEAAVRVRAAREAQERLIARAAHELRTPLALMRTGLDLALRRERGAEELRTVLEENRREVDRLASVAGALLELSAAGGALDFQQGDLRGLLDEAAAGAWAEADRRGVSLRVVGPDEADCRMDAMAVRRAVDNLLANALRYAPRGSEVRLELAHRDAHWEVAVQDEGRGIPETHREDVFTPFHRLERDAGGVGLGLSLVREVARGHGGDARVVESPGPGARVLLTLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6V8</accession>
    <name>Q1D6V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553451.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3418"/>
    <dbReference type="EnsemblBacteria" id="ABF92741">
        <property type="protein sequence ID" value="ABF92741"/>
        <property type="gene ID" value="MXAN_3418"/>
    </dbReference>
    <dbReference type="GeneID" id="41360765"/>
    <dbReference type="KEGG" id="mxa:MXAN_3418"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="MMITGYP"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="466" mass="51527" checksum="EEEE6A231183D8DB" modified="2006-07-11" version="1">MTDRPSVLVVDDKENMRHLITRILGDAYQVRTAEDGGRALSLIQTQPFDVVVTDIRMPGADGFEVLKAVKQHAPTTEVILMTAYASVPKAVEAIKEGAYDYLPKPFDPDEASLVVARAVERKRLKEQAASLRRELEGIYSFQNIIGRSAPMRALYGLLERASQLDITVLITGETGTGKELVARAIHHDGPRKDRPFIAVNCGALPSELIESELFGHARGAFTGAVETKAGLFEAASGGTIFLDEIGELPLSVQVKLNRTLQDKEVRRVGDAVARCIDARVITATHRDLKAEVTAGRFREDLYYRLNVFPVHLPSLRERREDIPLLAMHFVQKAAKTYRQPVDGLEPDALRALTGYTWPGNVRQLENAIERAVAITTGSRVGPDALPPEVTGGQQGALPVDHLVKMPFREAVDLARDRASRDYLIALLREFGGNVTRAAERAGMERESLHRLLKRFGLRSDDFKESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6W8</accession>
    <name>Q1D6W8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553441.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3408"/>
    <dbReference type="EnsemblBacteria" id="ABF87441">
        <property type="protein sequence ID" value="ABF87441"/>
        <property type="gene ID" value="MXAN_3408"/>
    </dbReference>
    <dbReference type="GeneID" id="41360755"/>
    <dbReference type="KEGG" id="mxa:MXAN_3408"/>
    <dbReference type="HOGENOM" id="CLU_1493227_0_0_7"/>
    <dbReference type="OMA" id="CGMRLPR"/>
    <dbReference type="OrthoDB" id="1509402at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="187" mass="19596" checksum="2018B2F4A7E964EC" modified="2006-07-11" version="1">MIICPLCDHVQPEGTECDVCGKRFPAAVAETAPIATLPELEVTPHAGGRAPVVAAVLPDLDVTRLRSGPDLPAQVVPDLQLTRARDMGAVPVTPMPELDTGRAPDDGVRTAAPLGAVVCRYCRITQAEGLLCDNCGMRLPRAKPTVAAAPGRPSGDDDGWRSCASCHTRVRPGKACPECGTRAQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Y2</accession>
    <name>Q1D6Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553427.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3394"/>
    <dbReference type="EnsemblBacteria" id="ABF90361">
        <property type="protein sequence ID" value="ABF90361"/>
        <property type="gene ID" value="MXAN_3394"/>
    </dbReference>
    <dbReference type="GeneID" id="41360741"/>
    <dbReference type="KEGG" id="mxa:MXAN_3394"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080406_0_0_7"/>
    <dbReference type="OMA" id="AACCISE"/>
    <dbReference type="OrthoDB" id="1332454at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="301" mass="33044" checksum="5923282BCA49B9D5" modified="2006-07-11" version="1">MQSPSGHGVRPCGVQRNDSLRQAIPLPPSVSRVGYAQCFEATMNNAPDDGFPADQRLLRRPGRTMPDALRQFVAETWVFRRQEELEAGLRFARLAGALEQLATPETLVELASRAAEDERRHAGMCELMARTYGQKVMPPVPLVARETAPQALGFRERVLYEVVAACCISETESTAGLTSVLAVDGPPRVRAVLRDILRDEVAHSRLGWGYLAHAAKSGSVAFLSPYLPEMLEESVSPRLFAKGLSDAEGSMLLAHGVLPHERKLEVFVQALHDVVFPGLERCGVDTTPGRQWVEHCRRSGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D748</accession>
    <name>RPOA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">MXAN_3326</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553361.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D748"/>
    <dbReference type="SMR" id="Q1D748"/>
    <dbReference type="STRING" id="246197.MXAN_3326"/>
    <dbReference type="EnsemblBacteria" id="ABF87159">
        <property type="protein sequence ID" value="ABF87159"/>
        <property type="gene ID" value="MXAN_3326"/>
    </dbReference>
    <dbReference type="GeneID" id="41360679"/>
    <dbReference type="KEGG" id="mxa:MXAN_3326"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_7"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264519" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="253"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="340" mass="37566" checksum="F574E3416CA90A6E" modified="2006-07-11" version="1">MADTFVAKNWRDLIKPRRMEVDQDSATPTYGKFVAEPLERGFGTTLGNSLRRVLLSSLQGAAITTVKIEGVDHEFTTIPEVSEDVTDVVLNLKEVLLRMHTNETKTLRIEAEGPKEVKAGDIITDPDTEILNPGHHICTISEGGKLRMELTCRRGRGYTPANVNKVAGSPIGTIPIDSLFSPIRKVNYQVTNARVGQVTDFDKLSLEVWTDGSVSPQDAVAYAAKIIKEQLTVFVNFDETEEPVVAEAPKEEAKLNENLFRSVDELELSVRSANCLQQANIKSIGDLVQRTEAEMLKTKNFGRKSLKEIKEILAEMGLSLGMKLENWPPKQAPAPAQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7R5</accession>
    <name>Q1D7R5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV leader peptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3105"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87121">
        <property type="protein sequence ID" value="ABF87121"/>
        <property type="gene ID" value="MXAN_3105"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3105"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_4_0_7"/>
    <dbReference type="OMA" id="DVKLMAG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="179" mass="18706" checksum="AE6B294CA99C11FD" modified="2006-07-11" version="1">MMTPVQIALWTVLGVALVISVVTDVLRREILDAVTYPLMAVGLGVRLATEGVGDLEHGLISGVVSGVGLALMLLSAALRGRMGWGDVKLMGGVGAVLGFPAVLAAAAFISLVGALQAVVTLLWQGAVWDTLAAVVRRWAVWVRLASADAQPAPQRHIPYGVAIALGTVWALWWQHGTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D874</accession>
    <name>Q1D874_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552998.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2939"/>
    <dbReference type="EnsemblBacteria" id="ABF86767">
        <property type="protein sequence ID" value="ABF86767"/>
        <property type="gene ID" value="MXAN_2939"/>
    </dbReference>
    <dbReference type="GeneID" id="41360304"/>
    <dbReference type="KEGG" id="mxa:MXAN_2939"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563716_0_0_7"/>
    <dbReference type="OMA" id="KRSWDYG"/>
    <dbReference type="OrthoDB" id="517836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="490" mass="53311" checksum="AD6446FA35393F4D" modified="2006-07-11" version="1">MQEFIDALRSQARHIAPDLARIAYQRGLAVTRPDGTTHPIPITATPVVLDAAEIRRRSELSARLSSATVKMAQAQLQGADAESLLGALSPLERVLAERTWRQSTRLATTRVDYFVAGGTPWALEVNATIPAMQGYSDIAARTFIEVVGRYFRYPEKSLHALLSLNGSNALALYRALLDGYAAERNGRMPDTVALLCRRNDAQITELRWLCERFREFGADADLVHPDEVSGDDAFVAHGKKYDLVYRHLFVRRLEESPSPWVEDFLGTVPGKKAVFLNPPASQVEVKLTFARLSQALAEPALAEAARLTGDELEAVRASVPWTRTFQPGPTQGPDGERVEDLVALVAATPARFVLKRAWDYGGRAVFLGRSAGTVPYTERVQVAYGAPMTWAELCARTAADTAGGGFVVQEVVDSPPEEHLLCEPNGTVLPTSFFVDYSAYASVGLARQPAWGGVCRGSMSEIVNIVGGGGVLPLITSEVASKLLMAWKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8L3</accession>
    <name>Q1D8L3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552860.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2793"/>
    <dbReference type="EnsemblBacteria" id="ABF91350">
        <property type="protein sequence ID" value="ABF91350"/>
        <property type="gene ID" value="MXAN_2793"/>
    </dbReference>
    <dbReference type="GeneID" id="41360169"/>
    <dbReference type="KEGG" id="mxa:MXAN_2793"/>
    <dbReference type="eggNOG" id="ENOG502Z8X0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031783_1_0_7"/>
    <dbReference type="OMA" id="RRILYMN"/>
    <dbReference type="OrthoDB" id="579461at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188493" evidence="2">
        <location>
            <begin position="27"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="39644" checksum="BB2C673A45B5AB97" modified="2006-07-11" version="1">MRTGGVMHLVRFRRLPALVLLGLSFAGGMGCSEDDGGVDTPNPLTNPKDGPPAGNQNPEATCAIPAEAGLADVARPTTVVGTGSPESCTSDAFIQAVARGGVITFDCGPEPVTITLERTAKIFNDTGPEIVIDGKGLVTLSGAGRHRILYMNTCDRDQVWTTAHCQDQDHPRLTLQNLTFVDASSKTEAEFDGGGAVWVRGGRLKVINSRFFNNVCSDVGPDVGGAALRAFSQHRNQPVYVVNTTFGGKAGYGGACSNGGGISSIGVSWTIINSLFSHNRAVGNGANPARPGTPGGGSGGAIYNDGNTMTLSLCGTRIEHNEVNAHGSAIFFVSNDHSGDIRIDRSVIRNNTGGSWYPTHPQISNHDDTPIVVTNSTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8M4</accession>
    <name>Q1D8M4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552849.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88340">
        <property type="protein sequence ID" value="ABF88340"/>
        <property type="gene ID" value="MXAN_2782"/>
    </dbReference>
    <dbReference type="GeneID" id="41360158"/>
    <dbReference type="KEGG" id="mxa:MXAN_2782"/>
    <dbReference type="eggNOG" id="ENOG50319TH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101912_0_0_7"/>
    <dbReference type="OrthoDB" id="1726249at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28615" checksum="E10B5C0943CEBAF0" modified="2006-07-11" version="1">MNKLASIAALFLAATALVVALWSPRETVQAPPPSPPPEQPTSVAADVINLERRVKALEDTSISLSRRLMEVERRPTLTADGKVVASPPPAALAAEVEQLRAEVRGMVAGEALNSEGGRDYLKDAVRNVQNEMRNEQRAERQQQWQQAQVQQQAQQQERVRKFITDARLNYTQEQTLSRRLEAESTKRQALMEEVRAGTKTVRDMRQALRTESQQTDQEMNAILDEGQRSQYQSLRREDRPVGGPPGGQRGGQGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D900</accession>
    <name>Q1D900_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552724.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2654"/>
    <dbReference type="EnsemblBacteria" id="ABF89405">
        <property type="protein sequence ID" value="ABF89405"/>
        <property type="gene ID" value="MXAN_2654"/>
    </dbReference>
    <dbReference type="GeneID" id="41360030"/>
    <dbReference type="KEGG" id="mxa:MXAN_2654"/>
    <dbReference type="eggNOG" id="COG4137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="MPGEFIT"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="2">
        <location>
            <begin position="61"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="28621" checksum="6DCD18CEE4547AE9" modified="2006-07-11" version="1">MSHTLVSLACHAYGIAAVVYLAYLVRQSEALATAGRVLVGGGLALHGVALFELLGVQSGRPVGLAQGFSALAFLLLAIFLFLDVRYRRPVIGAFLTPLALAALLPGLLLQGGQAPLPPGVRQPLLPLHITLALMGLAAFAVAAGVGVMYVLMERQVKAKRFGLLFSRLPSLEFLDTLNRRLVVWGFLALSITLATGAFFVGTAPGPWTVDGKTLATLVAWAVFAALLVARSVAGWRGRRVAFLTMAGFCLVMVSFLSSYDVSSPSAAMRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9L5</accession>
    <name>Q1D9L5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III secretion apparatus protein, YscI/HrpB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552513.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2438"/>
    <dbReference type="EnsemblBacteria" id="ABF90633">
        <property type="protein sequence ID" value="ABF90633"/>
        <property type="gene ID" value="MXAN_2438"/>
    </dbReference>
    <dbReference type="GeneID" id="41359822"/>
    <dbReference type="KEGG" id="mxa:MXAN_2438"/>
    <dbReference type="HOGENOM" id="CLU_1873195_0_0_7"/>
    <dbReference type="OMA" id="LQASMYQ"/>
    <dbReference type="OrthoDB" id="1812990at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="138" mass="14734" checksum="9961110789B2A8CB" modified="2006-07-11" version="1">MDAAQQVNKAQAAQATQRTDAVRQVETVNKTEKAALNKVHGAQESVTTKAAEPVTAKAEASKSSKAGDMMTQIVGDLEKGQVNLEHIIKQASSGKAFSNAELLSLQASMYQYTQQLDLTSKVVEKATTGLKDVVKTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9N4</accession>
    <name>Q1D9N4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pbpC</name>
        <name evidence="14" type="ORF">MXAN_2419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2419"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93096">
        <property type="protein sequence ID" value="ABF93096"/>
        <property type="gene ID" value="MXAN_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2419"/>
    <dbReference type="eggNOG" id="COG4953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_7_3_7"/>
    <dbReference type="OMA" id="APENFDM"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011815">
        <property type="entry name" value="PBP_1c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009647">
        <property type="entry name" value="PBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06832">
        <property type="entry name" value="BiPBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02073">
        <property type="entry name" value="PBP_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="12">
        <location>
            <begin position="68"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="11">
        <location>
            <begin position="323"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="BiPBP_C" evidence="13">
        <location>
            <begin position="707"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF93096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="796" mass="86611" checksum="D0B6903DCE17A18E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V7</accession>
    <name>Q1D9V7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552421.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90850">
        <property type="protein sequence ID" value="ABF90850"/>
        <property type="gene ID" value="MXAN_2346"/>
    </dbReference>
    <dbReference type="GeneID" id="41359731"/>
    <dbReference type="KEGG" id="mxa:MXAN_2346"/>
    <dbReference type="HOGENOM" id="CLU_569635_0_0_7"/>
    <dbReference type="OMA" id="FFNTMRP"/>
    <dbReference type="OrthoDB" id="552800at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="519" mass="56223" checksum="8951BA4DC63A7CCF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z4</accession>
    <name>Q1D9Z4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE</name>
        <name evidence="11" type="ORF">MXAN_2309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552384.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2309"/>
    <dbReference type="EnsemblBacteria" id="ABF86525">
        <property type="protein sequence ID" value="ABF86525"/>
        <property type="gene ID" value="MXAN_2309"/>
    </dbReference>
    <dbReference type="GeneID" id="41359696"/>
    <dbReference type="KEGG" id="mxa:MXAN_2309"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_7"/>
    <dbReference type="OMA" id="EYCTPIQ"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="418" mass="46293" checksum="3CD3EC436FBA924C" modified="2006-07-11" version="1">MSDTFDNLGLSRETLGALRRARFTQPTPIQQQAIPPALAGRDVIGCAATGTGKTAAYVLPLVERLAGKKGTLALVLAPTRELVQQIAEPVRFFAEPRRLTHATVIGGEDMGAQVNALKTLPSFVIATPGRLVDLMENTAIRFPHLEALVLDEADRMLDMGFLPQLERIVAHLPRRRQTLLFSATLGPDVTRFAKSRLYKPVRLEVTRSGTPAERAEQRLYFLRPEEKTPLLLTLLAQDSATALVFTRAKERVDKVQRALQRAGHRTAVLHADRTQNQRKQAMEGFRNGTYRCLVATDIAARGLDVEDVGHVINYDLPHAAEDYVHRIGRTARAAASGVASTFATTREGQVITRIEHLMRSEIPRVQVPREDPVFKEAWEAFLAAQKDPGPPQKDHGQSKRAPDLAPGRHARSHGKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA74</accession>
    <name>Q1DA74_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2228"/>
    <dbReference type="EnsemblBacteria" id="ABF92150">
        <property type="protein sequence ID" value="ABF92150"/>
        <property type="gene ID" value="MXAN_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2228"/>
    <dbReference type="eggNOG" id="COG0819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276928_0_0_7"/>
    <dbReference type="OMA" id="ARATRCI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23856" checksum="65FB44AF97CAFE26" modified="2006-07-11" version="1">MAVLEQEARGLVAALDVQPDARRLFDGTIDTEGYIHYLIQTYHYARWSTPMLAEAGHRLERQGRHPHLAELLVQKAGEERGHEKWLLSDLKNLGCPEVRVETAARTPAVDAYTGWNFFTSRSGVPTAVLGTAYVLEYLSQTRATGVVERLIAADAIPNIRKSVTFLRSHGALDGDHVAEMEAVLRTLTDPEDQAAVIFSARATRCIYPGIFRER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAN9</accession>
    <name>PANB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="1">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panB</name>
        <name type="ordered locus">MXAN_2055</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552139.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAN9"/>
    <dbReference type="SMR" id="Q1DAN9"/>
    <dbReference type="STRING" id="246197.MXAN_2055"/>
    <dbReference type="EnsemblBacteria" id="ABF85913">
        <property type="protein sequence ID" value="ABF85913"/>
        <property type="gene ID" value="MXAN_2055"/>
    </dbReference>
    <dbReference type="GeneID" id="41359464"/>
    <dbReference type="KEGG" id="mxa:MXAN_2055"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_7"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000297304" description="3-methyl-2-oxobutanoate hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="305" mass="32373" checksum="B0667B82A20D44C1" modified="2006-07-11" version="1">MKDKVTIHTLKRFKQIGQKICMVTAYDATFAHILEEAGADVLLIGDSLGMVIQGHDSTLPVTMDQMVYHTAAVARGARRAHVVADLPFMSYQVSNQEAVRNAGRLVAEGGAGSIKLEGGAEFADTVRAIVRASIPVMGHLGLTPQSVHKMGGYVVQGRGEDQARQILDDALALEQAGAYALVLEGVPMDLARTVTQRLSIPTIGIGAGVDCDGQVLVCYDLLGMNPDFKPKFVKRYANLHGSITEAAGAYFAEVRKGAFPDEEHSFKATKNIRLAPGAPAPAARVEPSAPAEAGEKLGPVYGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAP6</accession>
    <name>Q1DAP6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2048"/>
    <dbReference type="EnsemblBacteria" id="ABF87436">
        <property type="protein sequence ID" value="ABF87436"/>
        <property type="gene ID" value="MXAN_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2048"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="TNSACIF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="23357" checksum="EBA3799BE97D047D" modified="2006-07-11" version="1">MLLFKPRLFCEPSLFGHAMLFFEPRFFRQPSLFSETRLFGYASLFCETCLFRQTALFFETCLFSETCLFRQTTLFFETSLFRESSLFRESSLFRETSLFRQSTLFFETSLFRQTSLFRQTSLFRQTSLFRQSSLFRQSTLFFETSFFGEPSLFRQSALLFEPLLFRQAGLFREASFFGETGLFREASFFGEPRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB21</accession>
    <name>Q1DB21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552008.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89999">
        <property type="protein sequence ID" value="ABF89999"/>
        <property type="gene ID" value="MXAN_1907"/>
    </dbReference>
    <dbReference type="GeneID" id="41359321"/>
    <dbReference type="KEGG" id="mxa:MXAN_1907"/>
    <dbReference type="eggNOG" id="COG2842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263414_0_0_7"/>
    <dbReference type="OMA" id="ERRGWIR"/>
    <dbReference type="OrthoDB" id="47027at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1260" mass="142435" checksum="8413B937E488FED4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB69</accession>
    <name>Q1DB69_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551960.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1858"/>
    <dbReference type="EnsemblBacteria" id="ABF91347">
        <property type="protein sequence ID" value="ABF91347"/>
        <property type="gene ID" value="MXAN_1858"/>
    </dbReference>
    <dbReference type="GeneID" id="41359274"/>
    <dbReference type="KEGG" id="mxa:MXAN_1858"/>
    <dbReference type="HOGENOM" id="CLU_2275736_0_0_7"/>
    <dbReference type="OMA" id="AAFTCAY"/>
    <dbReference type="OrthoDB" id="2145209at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188096" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="97" mass="9747" checksum="E3CD821DC230A497" modified="2006-07-11" version="1">MKALLLTPLLAAALLTRCRAPDGCAPVSTRCAGNVAQICNGDGNWQPLADCDAVSEHSGAAFTCAYVNEEGVAGHTCLPTTVDAGTVDAGTEEGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB2</accession>
    <name>Q1DBB2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551920.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1815"/>
    <dbReference type="EnsemblBacteria" id="ABF86286">
        <property type="protein sequence ID" value="ABF86286"/>
        <property type="gene ID" value="MXAN_1815"/>
    </dbReference>
    <dbReference type="GeneID" id="41359232"/>
    <dbReference type="KEGG" id="mxa:MXAN_1815"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045796_0_0_7"/>
    <dbReference type="OMA" id="HWVVAVK"/>
    <dbReference type="OrthoDB" id="994146at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="37263" checksum="2003D3B2600533AB" modified="2006-07-11" version="1">MWALQNKTPYAAERTWVRDKDGHHHWVVAVKATFDVDDAGRLRPADEQEPPLPAPVYWGEAGHSSLRFEAELVAPKPHTDVLVNACAHAPGERPAPSVEVAVRIHDVDKMLVVHGERYYTRGLTGVKPSSPKPFVTQPILYEWAWGGTDTHDADARKHVSDMRNPIGQGVASREARLVDQPAHRIEYLRGHPAKSGPAGFGPIASYWSPRLELAGTFDEAWRKTRHPLLPRNFDERFALCAPADQRPSRRLVGGEKVALVHLTPKGSLHFTLPRLSFGFATYFGAVRRFHEATLGTVVIEPEVKKVRMVLQTGLSVGPRDVDRLDFTAITERTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL8</accession>
    <name>Q1DBL8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1704"/>
    <dbReference type="EnsemblBacteria" id="ABF93142">
        <property type="protein sequence ID" value="ABF93142"/>
        <property type="gene ID" value="MXAN_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1704"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1516327_0_0_7"/>
    <dbReference type="OMA" id="ATQCANL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="19017" checksum="5FED6E0A09D9F912" modified="2006-07-11" version="1">MAPAWAHGADAAGSGPPRPSAPARHPHQGPFRSDAGEDVVYLQDGEATVEGLRFWGSPWQPAYNDWAFNLPRGAALASKWAAIPEGLDVLITHGPPAGFGDRSSVGGRGGCTDLRERVLAVRPRLHLFGHIHDDGGLWREGDTCFANVTTWECERAPTVLQLDARGVTEVSIPPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR5</accession>
    <name>Q1DBR5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551767.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89959">
        <property type="protein sequence ID" value="ABF89959"/>
        <property type="gene ID" value="MXAN_1656"/>
    </dbReference>
    <dbReference type="GeneID" id="41359097"/>
    <dbReference type="KEGG" id="mxa:MXAN_1656"/>
    <dbReference type="HOGENOM" id="CLU_2106326_0_0_7"/>
    <dbReference type="OMA" id="FAWIAGV"/>
    <dbReference type="OrthoDB" id="2021125at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="104" mass="11360" checksum="86E30B35643F2D0C" modified="2006-07-11" version="1">MKNGHGRWFAWIAGVVLLVGCGPADGEAPQPGEPVEEESSPPGIPAEYLGEGEVESSAICCNVKCSGTWYGPFPSIKYDLCAKYGRYYCPQKKLTYQGHAWRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCP4</accession>
    <name>Q1DCP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS30 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase IS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1322"/>
    <dbReference type="EnsemblBacteria" id="ABF85839">
        <property type="protein sequence ID" value="ABF85839"/>
        <property type="gene ID" value="MXAN_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1322"/>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035706_0_0_7"/>
    <dbReference type="OMA" id="MWERWRK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001598">
        <property type="entry name" value="Transposase_IS30_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01043">
        <property type="entry name" value="TRANSPOSASE_IS30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="233"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="400" mass="45160" checksum="9724FF9D6DEE7E11" modified="2006-07-11" version="1">MRGRERIRERCPVESRGKLGRMSGEDWLEVRRAVAAGQTQEEAARAAGVNERTLQRLLRRAGGIRRPALVRSTLRLSVAEREEVSRGVQAGESLRAIARRLGRAASTISREVGRAGKGREGYRAWLGEAAAARASRRPKQTKLLAQPQLRQEVERRLLRCWSPQQIAATLKRDFAHQPQMHVSHETIYRSLYVQTRGSLRKELAAYLRTGRPQRRPRGRASVLSGQLPGRVMLSERPPEAESRAVPGHWEGDLLVGKQGKSAIGTLVERRSRYVMLLHLPEGRTAPHVREALTHQLGQLPDALRRTLTWDQGKEMAEHVRFTIDTDVQVYFCDPHSPWQRGSNENTNGLLRQYFPKGMDLSGLSRAQLDTVALQLNTRPRQTLDWRTPAEVFAQSVAMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCY9</accession>
    <name>Q1DCY9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551344.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1225"/>
    <dbReference type="EnsemblBacteria" id="ABF89648">
        <property type="protein sequence ID" value="ABF89648"/>
        <property type="gene ID" value="MXAN_1225"/>
    </dbReference>
    <dbReference type="GeneID" id="41358674"/>
    <dbReference type="KEGG" id="mxa:MXAN_1225"/>
    <dbReference type="HOGENOM" id="CLU_1097989_0_0_7"/>
    <dbReference type="OMA" id="WMAADEL"/>
    <dbReference type="OrthoDB" id="2014289at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="27113" checksum="66BCBAD121734FF6" modified="2006-07-11" version="1">MPFLSLNGITVPVVEGRRRQVSIGVDSRSFSGVYRLGRRATRQEWEFKTGPLSSVEALAFRGLIAGDGHALAFDGDTFTSRGLAPSIATGSLFQGARFGGGFELPLGVSCSWAMQLGPRWTTLHHLFDATGGVWLQVINRSDGARWMQGTAAASAGGLIVSSGSLSLTGALNLRRFDDVVGLPFMAPDSWVPEVAAWHSARAWSALPYLSAGGAFSVGETKVLGEVRDGEFVEFIHQGARVIGERLEFTLREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD33</accession>
    <name>Q1DD33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551300.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1181"/>
    <dbReference type="EnsemblBacteria" id="ABF86033">
        <property type="protein sequence ID" value="ABF86033"/>
        <property type="gene ID" value="MXAN_1181"/>
    </dbReference>
    <dbReference type="GeneID" id="41358631"/>
    <dbReference type="KEGG" id="mxa:MXAN_1181"/>
    <dbReference type="eggNOG" id="COG1656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029780_0_0_7"/>
    <dbReference type="OMA" id="GFQHRMG"/>
    <dbReference type="OrthoDB" id="208992at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025235">
        <property type="entry name" value="DUF4178"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13785">
        <property type="entry name" value="DUF4178"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4178" evidence="2">
        <location>
            <begin position="59"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4178" evidence="2">
        <location>
            <begin position="270"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="70104" checksum="D8DD044FE1D58FCF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD73</accession>
    <name>Q1DD73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551260.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87811">
        <property type="protein sequence ID" value="ABF87811"/>
        <property type="gene ID" value="MXAN_1140"/>
    </dbReference>
    <dbReference type="GeneID" id="41358591"/>
    <dbReference type="KEGG" id="mxa:MXAN_1140"/>
    <dbReference type="HOGENOM" id="CLU_917731_0_0_7"/>
    <dbReference type="OMA" id="FRTCATL"/>
    <dbReference type="OrthoDB" id="1018598at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="36037" checksum="FC23EAFF2B89DDDE" modified="2006-07-11" version="1">MPRASAQLGHVHGPSSDLCGRDAVSHRVPGRCGLLPGGPTMKRLGAAVLVMAVGCAPLDVERRTERGPLLRTYAQEKALNERIPFATTQVQWPQLTLAFSSSDICRTEQHGEYAEDIISTHSNTGAAAAVSTGGILTVLGGTLLVGRTLFSDTPNRSAIDEKGRYGASSRDVATGWGLGLLIAGVPAVVAGIVQLSRSGETRETRKTDELLSLREVPCQPKPVDGVVELAGGPGPQPPPRLTLNGALVLTADEIRQLSFVGLALDGTPVTLEEEDLDRLETFRTCATLLATPVDPQALAGEARSQPDRLRMKRELARGCTTLPGAPAQPLLEAIEGALGSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDB0</accession>
    <name>Q1DDB0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ORF">MXAN_1103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551223.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1103"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ABF86592">
        <property type="protein sequence ID" value="ABF86592"/>
        <property type="gene ID" value="MXAN_1103"/>
    </dbReference>
    <dbReference type="GeneID" id="41358555"/>
    <dbReference type="KEGG" id="mxa:MXAN_1103"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_7"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="478" mass="51517" checksum="F98E309BE034692A" modified="2006-07-11" version="1">MRSCSAHRSKGVRQRAMCGIFGIVGHAEASNLTYLGLHALQHRGQESAGIVASDGMGLRAHRQMGLVADIFDAPVLADLPGQAAIGHVRYSTAGGSALKNAQPLFVQYAGGQCAIAHNGNLVNAAELKQQLEADGAIFQSDADTEVILHLLARSKQATFEQKLVEALRKVTGAYSLLVLTENKLVAVRDPHGIRPLVLGRMKEGAYVLASESTALDLIEAETVRELEPGELLVIENGLLRTSKPFAEPPRQARCIFEHVYFARPDSTLFGSNVYEVRKEMGRQLAKEQPAPSADLVIAVPDSGVPAAIGFAQASGIPYDVGLIRSHYVGRTFIEPQQSIRHFGVKLKLSAVRQVLKGKRVVVVDDSIVRGTTSRKIVKMIKAAGAVEVHLRISSPPTKWPCYYGIDTPSRQELIAATHSLEEIATYVTADSLGYISQEGLGRAVGDPERGSFCTACFSGKYLIGDFGEERAEPSKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP2</accession>
    <name>Q1DDP2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cys/Met metabolism PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551091.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0970"/>
    <dbReference type="EnsemblBacteria" id="ABF86239">
        <property type="protein sequence ID" value="ABF86239"/>
        <property type="gene ID" value="MXAN_0970"/>
    </dbReference>
    <dbReference type="GeneID" id="41358428"/>
    <dbReference type="KEGG" id="mxa:MXAN_0970"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_7"/>
    <dbReference type="OMA" id="THGGIIV"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="366" mass="39158" checksum="C356F4FEDDB69598" modified="2006-07-11" version="1">MKLATALVHAGVRRDPTTGAVAVPIYQSATFQHPALGQSTGYDYSRTRNPTRSALEDALAQLEGGSRGLAFSSGMAALHCALQLFGPEDHILLTEDLYGGTYRLVDRILHVPCTFVDTSHPSAVRDALRPNTRAIVVETPTNPMMRTADLSELAAIARKAGVLLIVDNTFLTPWLQRPLELGADIVVHSATKYLAGHNDVVAGALVVKDAALGERLAYLQNGIGAILGPQDAYLVIRGLKTLALRMERHQANAREVAAWLRAHPGVERVFYPGVGGMLSFTVAHAALVPQVLASVQLCLFAESLGGVETLITYPTTQTHADIPAERREALGISDRLLRLSVGIEDSHDIIADLAQALRDPSAAHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY0</accession>
    <name>Q1DDY0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551003.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0882"/>
    <dbReference type="EnsemblBacteria" id="ABF86973">
        <property type="protein sequence ID" value="ABF86973"/>
        <property type="gene ID" value="MXAN_0882"/>
    </dbReference>
    <dbReference type="GeneID" id="41358341"/>
    <dbReference type="KEGG" id="mxa:MXAN_0882"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="VNQINHE"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="497" mass="53139" checksum="6E97D2F48568B78C" modified="2006-07-11" version="1">MGSDDAFMQTMQSSAEAPVSDAGPRASDEELQEGSTLGNYQLEQLLGEGSMGRVFQARHTRLGRQVALKVLRPEHARDGGFVRRFFQEARTVNQINHEHIVEIFDFVDESAMGGHVYCVMELLRGQSLSSLAQAEPLTLARIQRFVVQVCAALGAAHQVGVVHRDVKPDNLFVIHRAGQPDFVKVLDFGVAKLLTAEGSTTGTVDGTIIGTPAYMAPEQAAGLPVDARSDIYAVGNILYELISGKPPFQAPAFGHLVVQIITQPPPPLPSHLPSGEPVPPQLAELVMRCLSKEPEARPQSLTEVTTSLLLLPASAQALTPAPAELALEASERPTHKVQVAVTGRWHRRAVVTVGTAALVVVAAVVTWSGMQPEPAPAEAPVAQVADVVGRPAAAPQLLPPVTLTVRSFPEGAQVLRLDTGELLGVTPLVKQVSGEAAPLRLRVELAGYAPLERMVDLDKHAELEVPLVKALPSPRQKPAAGTQRDTGKKSRERPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY5</accession>
    <name>Q1DDY5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550998.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0877"/>
    <dbReference type="EnsemblBacteria" id="ABF87740">
        <property type="protein sequence ID" value="ABF87740"/>
        <property type="gene ID" value="MXAN_0877"/>
    </dbReference>
    <dbReference type="GeneID" id="41358336"/>
    <dbReference type="KEGG" id="mxa:MXAN_0877"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_7"/>
    <dbReference type="OMA" id="IDIDFNR"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="21444" checksum="47E65EF28CBB8BE5" modified="2006-07-11" version="1">MAQVKAVLLDLGNVLVFHDNTLLFSRLGARAGLEAAEVARRLTGAGWTDANRGVLGAEGIRQDVCRALDVDLPMAEFAPLWSSHFTLHDAVLPRIESLVGRVRLGLVSNTNALHVAYLRPLLPVLQRFDSVVMSCEVGHVKPEPDIFRLALTGVGCAPEEAVFFDDLAEFVQAAEAVGIQGRLFTTADAFDAQLKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE73</accession>
    <name>Q1DE73_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase, DEAD/DEAH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550910.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0787"/>
    <dbReference type="REBASE" id="41920">
        <property type="entry name" value="MxaDKORF787P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91055">
        <property type="protein sequence ID" value="ABF91055"/>
        <property type="gene ID" value="MXAN_0787"/>
    </dbReference>
    <dbReference type="GeneID" id="41358254"/>
    <dbReference type="KEGG" id="mxa:MXAN_0787"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005588_0_0_7"/>
    <dbReference type="OMA" id="MTKSYKM"/>
    <dbReference type="OrthoDB" id="16977at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <location>
            <begin position="348"/>
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        <location>
            <begin position="542"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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            <dbReference type="EMBL" id="ABF91055.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
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</entry>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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                <person name="Shvartsbeyn A."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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            <end position="94"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="61"/>
            <end position="78"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF93037.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF88113"/>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLH55589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="24945" checksum="212C3607C7C4CA79" modified="2006-07-11" version="1">MEAPLAAQPPGIRGWTGFLPSVPGQARGSSPCVTGRVPTVVATSRRQDWKERHMAEPQTLSPSTPRLVPSQVPPKGRFRRGVRRAMDRSAAAGIISRPLLGRLPLRRWVPQDLHSLMDYKGGTASVVAGVLSGDAVAKSAGIALGSTILGVSLLTDYRISLTKLIPIEAHEIADYAFGAASILSPFVLGYAKRSPLAAAIHVAVGVTTVLASLVTDYRCQTGMHLGGELATDPGAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DER7</accession>
    <name>Q1DER7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0588</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
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    </reference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="793" mass="87352" checksum="0A2C8A8099B4575B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DES4</accession>
    <name>IF3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism>
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    </organism>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Barbazuk W.B."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550712.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DES4"/>
    <dbReference type="SMR" id="Q1DES4"/>
    <dbReference type="STRING" id="246197.MXAN_0581"/>
    <dbReference type="EnsemblBacteria" id="ABF88845">
        <property type="protein sequence ID" value="ABF88845"/>
        <property type="gene ID" value="MXAN_0581"/>
    </dbReference>
    <dbReference type="GeneID" id="41358060"/>
    <dbReference type="KEGG" id="mxa:MXAN_0581"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_0_3_7"/>
    <dbReference type="OMA" id="RFLAITC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000004545" description="Translation initiation factor IF-3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="247" mass="27145" checksum="6052DAC6407FAEA7" modified="2006-07-11" version="1">MIREQRSSRGGSRDQRTNRRIRAREVRVVGSDGSQLGVMPLEAALDRARTEGLDLVEISPMASPPVCKIMDYGKFKYEEKKKASEAKRAQVTVLLKEVKLRPKTEEHDYEFKVRNTRRFIEDGNKAKVVIQFRGREITHREQGTAILDDVAKDLKDVAVVEQMPRMEGRLMFMILAPTPKVAQKARELVRQAATAAKRPPPPGAPGAGKSAAGASSGAEEKAEETAEEKKEAQAAPAAAEAQSPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ9</accession>
    <name>Q1DEZ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550637.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88649">
        <property type="protein sequence ID" value="ABF88649"/>
        <property type="gene ID" value="MXAN_0505"/>
    </dbReference>
    <dbReference type="GeneID" id="41357991"/>
    <dbReference type="KEGG" id="mxa:MXAN_0505"/>
    <dbReference type="HOGENOM" id="CLU_1813738_0_0_7"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="142" mass="15238" checksum="32AE4DEDE17614CE" modified="2006-07-11" version="1">MRIDGGAAITLGGSVTSHVLTADLSPGVHFVIVTACDRFDHCGSTPVRSFEVVGTQPTAPAPLAPTGSTYVATPRPEFSWAPATDDVGIDDQEYAISDSDSVLYLEELLDYVEHTWFVRACDLAGNCTDSPSQVFTIRPYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF20</accession>
    <name>Q1DF20_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, 2-nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550616.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0483"/>
    <dbReference type="EnsemblBacteria" id="ABF86659">
        <property type="protein sequence ID" value="ABF86659"/>
        <property type="gene ID" value="MXAN_0483"/>
    </dbReference>
    <dbReference type="GeneID" id="41357975"/>
    <dbReference type="KEGG" id="mxa:MXAN_0483"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_9_2_7"/>
    <dbReference type="OMA" id="KGDEGWG"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="2">
        <location>
            <begin position="44"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="42219" checksum="43BE5C805297C184" modified="2006-07-11" version="1">MNGANDGRSPPSSRESEPDDERSDSSPEPRRPPIYVLEGNTLHTRLTRELGVNYPFVSDGMAFVSLPPLVIAVSEAGGVGMLGAAPEPADVLDVRLQTIQAGTRRPFGVNFLMAQRDGRHSTTREHIEACIARRVPVVSFHGGLPPEEWVAAMRAAGVRVWVQAPSGEVARQALLLGVDGLIAQGRQASGLNQSTTPTLALVRELRALTDSVPVLAAGGIADGLSAARALFHGADGVWVGTRMVASVEAHAHPAYKQRIVDGDAGDTDVTTVFGREWPGHRMRVLRNRVVREWTGREGRVPMPMATPERVGTTRLFPGTPGGGPLVDVPRHSAFVPTPDTEGDLEEMAMPASGASMARIESVLPAGQIVVELMERARRVLADPHGLDADADEDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFM6</accession>
    <name>Q1DFM6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550411.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0266"/>
    <dbReference type="EnsemblBacteria" id="ABF90982">
        <property type="protein sequence ID" value="ABF90982"/>
        <property type="gene ID" value="MXAN_0266"/>
    </dbReference>
    <dbReference type="GeneID" id="41357766"/>
    <dbReference type="KEGG" id="mxa:MXAN_0266"/>
    <dbReference type="eggNOG" id="COG4676">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048098_0_0_7"/>
    <dbReference type="OMA" id="FHRYPTE"/>
    <dbReference type="OrthoDB" id="840067at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="42514" checksum="1E67D41F119B315F" modified="2006-07-11" version="1">MPAGGGGRPLAEKEASPMVSELPLRSRWGAVCLSGVLLFSTPGLARGGDGSPEVPVDAPLQAHVGPSQQSLAQVPPPPSERPDFKPLAVAVAVVPGLLFHGLGPLVAGDRHTAKRLFALEGAGLGLIALGGVPIALTGASRRTIAPLYAVTLAGFSVLGISALANLYAVTAPAFDAGVAPPLLPPLELEVGYQYVNDAAFDYRHFLTVGAQARFDSLRLLGTVRVDPSEGNTQVRLGGAWRLLGAPERALSGTDGSALDVEAFGQFHRYPTEGFALISGEVALRGRLAMSRISPAMAGSFAEVSVGTSAEAYTYPGAVSDGNLHEQLLFTFGYGVWLGRGGPFRGEAMLYYDHRKDSFAGGIRSRGGGIVGAFGLRGRALLTDDWGVAAEVQGGGALVGRLSLIRALGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFV7</accession>
    <name>Q1DFV7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550330.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0183"/>
    <dbReference type="EnsemblBacteria" id="ABF90526">
        <property type="protein sequence ID" value="ABF90526"/>
        <property type="gene ID" value="MXAN_0183"/>
    </dbReference>
    <dbReference type="GeneID" id="41357686"/>
    <dbReference type="KEGG" id="mxa:MXAN_0183"/>
    <dbReference type="HOGENOM" id="CLU_147976_0_0_7"/>
    <dbReference type="OMA" id="QAVPNDM"/>
    <dbReference type="OrthoDB" id="1951587at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="15456" checksum="19EE8C30E6FAB6E8" modified="2006-07-11" version="1">MTRWLPFLVLALPACALFQRPPRPVHAPPEEAARFEFPPTGIPEEGLRSIPGDMARAIQLAMEDFYPWDKKAPTPSHPGRECLYRRESYDVYAAPYQEGVVLVGIVLSPQACGAQAVPNDMGALYAVDTRGWRILAVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFW3</accession>
    <name>Q1DFW3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550324.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0177"/>
    <dbReference type="EnsemblBacteria" id="ABF86280">
        <property type="protein sequence ID" value="ABF86280"/>
        <property type="gene ID" value="MXAN_0177"/>
    </dbReference>
    <dbReference type="GeneID" id="41357680"/>
    <dbReference type="KEGG" id="mxa:MXAN_0177"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_7"/>
    <dbReference type="OMA" id="LCITRAI"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="29781" checksum="0715B4E711A8833F" modified="2006-07-11" version="1">MMLYAGIAGSVLVGILLGLLGGGGSILIVPLLIYVLDVEPRTAIAMSLVVVGVTSASSAFLHARAGRVRWRTALVFGAGGMGGAFLGGRLNPHLAPDTLLLLFGSVMVAAAVAMLRRREAGPAATSVSPLPAARVLAQGIAVGALSGLVGAGGGFLIVPALSLAGLPMPVATATSLVVIALQCAAGLVGHLGHLDLPWVLTGEVLLAAMTGSLVGGRLAGRVSPAMLRKGFAVFVLTTAAFLLGAQSPAPLRERVWTEGLWLWSVAPLAVGIPVTVWRLRVARQRQAAQALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGD3</accession>
    <name>Q1DGD3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550156.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0004"/>
    <dbReference type="EnsemblBacteria" id="ABF91172">
        <property type="protein sequence ID" value="ABF91172"/>
        <property type="gene ID" value="MXAN_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="41357512"/>
    <dbReference type="KEGG" id="mxa:MXAN_0004"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116683_0_0_7"/>
    <dbReference type="OMA" id="RCPRHEG"/>
    <dbReference type="OrthoDB" id="1639031at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="22180" checksum="A83C048226FE9553" modified="2006-07-11" version="1">MPPVLGSLPALASRRAGGGRCLGNVGCPRSGKRPKPDTGEATVMANIREEQGEAAEGRSATPSLKEQRSESHAAQTYMAFLKDLEANAGVVRGLAEKAAQSVLCLLEQRLMDTEAKHLEAQLPRKVRDMLKRCPRHEGKVARKYKLEQFLAMVAEELDTTPNEAERLARAVFVTVRNHISEGEADDVMGQLPADLRSLWVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="149" xmlns="http://uniprot.org/uniprot">
    <accession>Q306N8</accession>
    <name>Q306N8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pilS2</name>
        <name evidence="6" type="ORF">MXAN_5778</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="1249" last="1261">
            <title>The pilH gene encodes an ABC transporter homologue required for type IV pilus biogenesis and social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Wu J."/>
                <person name="Cheng Y.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9767592"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01013.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="24" last="33">
            <title>The Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pilus biogenesis, social motility, and development.</title>
            <authorList>
                <person name="Wall D."/>
                <person name="Kolenbrander P.E."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9864308"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>New pil genes required for pilus assembly, S-motility, and Tgl stimulation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK 1622</strain>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="DQ242507">
        <property type="protein sequence ID" value="ABB43052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555729.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5778"/>
    <dbReference type="EnsemblBacteria" id="ABF88543">
        <property type="protein sequence ID" value="ABF88543"/>
        <property type="gene ID" value="MXAN_5778"/>
    </dbReference>
    <dbReference type="GeneID" id="41363021"/>
    <dbReference type="KEGG" id="mxa:MXAN_5778"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_1_7"/>
    <dbReference type="OMA" id="ATMTHKL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="168"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="373" mass="40124" checksum="975C8D7850E25DD5" modified="2005-12-06" version="1">MKWRIASVAFLLGALSSGLTWLSVQPVLLRLLDALRRWVPEGSAEEATLARVQGLLPWVLGLDLVALTVLTYVVLDLMVGRPLRRTEAVVEQFGRLDWEAHLVPTQGGTLVSRIQRALQRMAEALREEQALTRAQMASLRASHAQLARTQTELVASERMATVGRLAAGVAHEVGNPLAGILGYVALARVKADTPELKDFLERIDHEVQRIDRIIRGLLDLGRPGVTSLGPVEVGPVVETCVRLVRASPELSGVTVTLDLEPGALARTDAGPLSQIVINLLLNAAQAMGGQGRVRVATRQAAGEVRLLVEDDGTGIPEDVMPRLFEPFFTTKGREGTGLGLAVSQRLAQVMGGRLEAENIPSGGARFTVCLPVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH7</accession>
    <name>RSMG_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="ordered locus">MXAN_7493</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42732"/>
            <dbReference type="Rhea" id="RHEA-COMP:10209"/>
            <dbReference type="Rhea" id="RHEA-COMP:10210"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.170"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557395.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CVH7"/>
    <dbReference type="SMR" id="Q1CVH7"/>
    <dbReference type="STRING" id="246197.MXAN_7493"/>
    <dbReference type="PRIDE" id="Q1CVH7"/>
    <dbReference type="EnsemblBacteria" id="ABF88142">
        <property type="protein sequence ID" value="ABF88142"/>
        <property type="gene ID" value="MXAN_7493"/>
    </dbReference>
    <dbReference type="GeneID" id="41364626"/>
    <dbReference type="KEGG" id="mxa:MXAN_7493"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_0_7"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000010171" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <sequence length="217" mass="22850" checksum="5F0CE92EAA34D3F2" modified="2006-07-11" version="1">MDNARFEDQLAAGCRALGVTVAADLGPRLQRLMSELLKWNAKVNLTAITAPEEVLEKHFLDSLAVLPEVTGAATLLDLGAGAGFPGLPLKLALPALGVTLVDTVGKKVAFIKAAAASLGLQGVRGLHARAEGQPETEGIPRAEVLIARAFMDLPDWLALAPAYVEPGGRVVAMLGKPQTDAELAARAAERQLRVVSARAYRLPFSGAERQVAVFAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVS1</accession>
    <name>Q1CVS1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">General secretion pathway protein, GspG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557307.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7395"/>
    <dbReference type="EnsemblBacteria" id="ABF89185">
        <property type="protein sequence ID" value="ABF89185"/>
        <property type="gene ID" value="MXAN_7395"/>
    </dbReference>
    <dbReference type="GeneID" id="41364553"/>
    <dbReference type="KEGG" id="mxa:MXAN_7395"/>
    <dbReference type="HOGENOM" id="CLU_091705_2_0_7"/>
    <dbReference type="OMA" id="HTNHDGH"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="3">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="15058" checksum="9D32C14234845130" modified="2006-07-11" version="1">MNASSDEPPPSRRSPVLFVGLVFGLGLVVAVLVGALSGSKAVHADRIHQDLALLEEALGRYRADKGTLPEDADVEELLVPAYLPSVPLDPWGRPYRYTSNGEEVFLSTFGKSGDRGGSGEEQDHTNHDGHAVPKVEPERT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW44</accession>
    <name>Y7266_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein MXAN_7266</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_7266</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="J. Bacteriol." volume="189" first="3738" last="3750">
            <title>Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.</title>
            <authorList>
                <person name="Viswanathan P."/>
                <person name="Murphy K."/>
                <person name="Julien B."/>
                <person name="Garza A.G."/>
                <person name="Kroos L."/>
            </authorList>
            <dbReference type="PubMed" id="17369305"/>
            <dbReference type="DOI" id="10.1128/JB.00187-07"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>OPERON STRUCTURE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="developmental stage">
        <text>Operon expression begins by 6 hours after starvation has initiated development and is under strong negative regulation by DevS.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CW44"/>
    <dbReference type="STRING" id="246197.MXAN_7266"/>
    <dbReference type="EnsemblBacteria" id="ABF87166">
        <property type="protein sequence ID" value="ABF87166"/>
        <property type="gene ID" value="MXAN_7266"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7266"/>
    <dbReference type="HOGENOM" id="CLU_3292844_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000418231" description="Uncharacterized protein MXAN_7266">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="17369305"/>
        </source>
    </evidence>
    <sequence length="40" mass="4499" checksum="782254CB84C9F933" modified="2006-07-11" version="1">MSLRKSKYEVLERLEVGLRIVSLALVVAKTLVELVDTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW81</accession>
    <name>Q1CW81_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92245">
        <property type="protein sequence ID" value="ABF92245"/>
        <property type="gene ID" value="MXAN_7228"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7228"/>
    <dbReference type="HOGENOM" id="CLU_3374781_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="34" mass="3572" checksum="7F0D06AF2FA91469" modified="2006-07-11" version="1">MRIEPCTTPSRPAAKVESGQSGWLLVTNTGPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWA6</accession>
    <name>Q1CWA6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7204"/>
    <dbReference type="EnsemblBacteria" id="ABF87775">
        <property type="protein sequence ID" value="ABF87775"/>
        <property type="gene ID" value="MXAN_7204"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7204"/>
    <dbReference type="eggNOG" id="COG5592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_2_1_7"/>
    <dbReference type="OMA" id="ERFDAKV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="27732" checksum="A628FA216A3ACBF4" modified="2006-07-11" version="1">MRPGRPCAARASKRRHPHHPRHAALRQGASGQRTLQGGESMDAIALLKADHKTAEQLFRKFEKAGPNAHKLKRRLVDQMVTELAVHAVIEEQVFYPAVRSRSEELGPDVLRSLEEHHVVKWLLAELDGMSPEAERFDAKVQVLMENVRAHVLQEESDLFPALKKVFRPQELRTMGDVLEMSRKAAPTRPHPMAPDTPPGNLVVGAVSAVMDMGRDALRAARRKATTKVRSVASRGPGQVVREMAGAEASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF8</accession>
    <name>Q1CWF8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557071.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7152"/>
    <dbReference type="ESTHER" id="myxxd-q1cwf8">
        <property type="family name" value="Est-OsmC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86757">
        <property type="protein sequence ID" value="ABF86757"/>
        <property type="gene ID" value="MXAN_7152"/>
    </dbReference>
    <dbReference type="GeneID" id="41364326"/>
    <dbReference type="KEGG" id="mxa:MXAN_7152"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681299_0_0_7"/>
    <dbReference type="OMA" id="AHCFTCS"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="49"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="398" mass="42364" checksum="FD38FAA6C4BAB1EA" modified="2006-07-11" version="1">MGARDVALRGAEGSVVTARLDLPPGRPVASAVRVGCFACLGPSPAPSRLAHALVARGFAVLSLDFTAPAAAGPRPDTVPSVEAVEAAAAWLRERYPPVRLLVGHSLGGTAAAAALPRLSEVAALALVNAPVGGGPLLERLSSTAREAGEGELDFGPGRLRLTRRFLQDIDEAHLRRALNAFPGELLVLHAPADRYVPLEHARRWMAMARRPASLMLLEGADHFLSHDADAGHAADVLGVWAARQVTPVREREAPLPPGVVEVHEAGEGRFAQDIRVGAHRLRSDEPLSVGGEDTGPTPYGLLTAALGACTAMTLRLYAARKGWPLEHVHVRLSHEKVHAKACEECETKDGKMDRLQRTVKLEGPLTDAQRATLVAIADRCPVHRTLASDVDVHTDVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWR1</accession>
    <name>Q1CWR1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556968.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7049"/>
    <dbReference type="EnsemblBacteria" id="ABF89334">
        <property type="protein sequence ID" value="ABF89334"/>
        <property type="gene ID" value="MXAN_7049"/>
    </dbReference>
    <dbReference type="GeneID" id="41364224"/>
    <dbReference type="KEGG" id="mxa:MXAN_7049"/>
    <dbReference type="eggNOG" id="COG1515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591036_0_0_7"/>
    <dbReference type="OMA" id="YKRELPC"/>
    <dbReference type="OrthoDB" id="1681607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="18017" checksum="56C5DF9E0D779251" modified="2006-07-11" version="1">MLACVDVDYRPELTVAGCVLFRNWTDGHEVSHLVEHGPPAAPYEPGQFYRRELPHLLRVLARVEVPLEAIIVDGYAWLGEDRPGLGAHLYEALNREVPVIGVAKTAYVTTGPSVPVLRGKSLRPLFVGAAGMDAATAAEHIRRMHGASRTPTMLNRVDRLCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWS3</accession>
    <name>Q1CWS3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative chemotaxis MotB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556956.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7037"/>
    <dbReference type="EnsemblBacteria" id="ABF86405">
        <property type="protein sequence ID" value="ABF86405"/>
        <property type="gene ID" value="MXAN_7037"/>
    </dbReference>
    <dbReference type="GeneID" id="41364212"/>
    <dbReference type="KEGG" id="mxa:MXAN_7037"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_14_0_7"/>
    <dbReference type="OMA" id="PKIDQFY"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="139"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="31816" checksum="BDC5D3C4B4CB0D1B" modified="2006-07-11" version="1">MTESTQHGQAQHGRPWVPWLVTALVVLMSGGVMYLAHRGTSQAEALAEQSRQSALDAATRARDAEAARLQLEQKLAALEAERAQLATEKEQLSSEKEQLSQTVQEQEAELAKLKATYDDLQDKMKAEIAEGAIRLSHAEGRIQVDLVDKVLFDSGDASISARGQEVLTRLGSVLAKVEDKSIQVSGHTDDSPPSQKLQSTFPSNWELSVARAVNVVRFLQDTGGVPARRLVAAGYGQMRPVSTNATPLGRARNRRIEVLLMPDLPSKRTPTAAVQRAVAGGTATKAQAKPARGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWW2</accession>
    <name>Q1CWW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556917.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6998"/>
    <dbReference type="EnsemblBacteria" id="ABF89462">
        <property type="protein sequence ID" value="ABF89462"/>
        <property type="gene ID" value="MXAN_6998"/>
    </dbReference>
    <dbReference type="GeneID" id="41364174"/>
    <dbReference type="KEGG" id="mxa:MXAN_6998"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_0_7"/>
    <dbReference type="OMA" id="KMMPSVP"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18236" checksum="64D608510E3D927E" modified="2006-07-11" version="1">MSLARTHKVDAVKTHLEGPAPPRQRPRSQPRSPADRARKSREQLESRLAESVGEAARGARLLAGLTQAEVAGRVGIAAEVYGRMERGKMMPSVPTLFRLCLALRLSADVGLGLATAASVGAALWEEDSRHRDQLPEMRKVLRTLRRMSRSQLNLMNQVAAAILPER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX36</accession>
    <name>ATPB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">MXAN_6923</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556843.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CX36"/>
    <dbReference type="SMR" id="Q1CX36"/>
    <dbReference type="STRING" id="246197.MXAN_6923"/>
    <dbReference type="PRIDE" id="Q1CX36"/>
    <dbReference type="EnsemblBacteria" id="ABF88655">
        <property type="protein sequence ID" value="ABF88655"/>
        <property type="gene ID" value="MXAN_6923"/>
    </dbReference>
    <dbReference type="GeneID" id="41364105"/>
    <dbReference type="KEGG" id="mxa:MXAN_6923"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_7"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000254310" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="481" mass="51766" checksum="625B71540C614F4F" modified="2006-07-11" version="1">MSAQVPTAGRIIQVLGPVVDVEFPPGGLPEVYTALKVTNANLSAAADNLTLEVAQHLGENTVRTIAMDSTEGLGRGMAVTNTGAPIQVPVGKATLGRILNVTGEPVDEMGPVKAQEYWSIHRAPPPFTEQDVRVQMFETGIKVIDLLAPYTRGGKIGLFGGAGVGKTVLLQELIRNVAVERGGFSVFAGVGERTREGNDLYHEMQDTKVIQTDNLEASQAVLVYGQMNEPPGARARVALSALTMAEYFRDVEGRDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGGLQERITSTTKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLNRSIAELAIFPAVDPLDSTSRILDPAVIGAEHYGVARKVQGILQRYKELQDIIAILGMDELSEDDKLVVARARKIQRFLSQPFFVAKVFTGKDGRYVKLQDTIQGFKEIAEGKHDDIPEGAFYMTGSIDEVVENARKLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXE0</accession>
    <name>Q1CXE0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6816"/>
    <dbReference type="EnsemblBacteria" id="ABF91667">
        <property type="protein sequence ID" value="ABF91667"/>
        <property type="gene ID" value="MXAN_6816"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6816"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2634390_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188007" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="77" mass="7941" checksum="2223A5F19EF054AB" modified="2006-07-11" version="1">MQRGWWGGETMRPPSGVALSLAVLLFAQAGQAQTAAKEAAPPPADLPPGVSAALWKLSVPASLAPTPERVLLGEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXG5</accession>
    <name>Q1CXG5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556716.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6791"/>
    <dbReference type="EnsemblBacteria" id="ABF92353">
        <property type="protein sequence ID" value="ABF92353"/>
        <property type="gene ID" value="MXAN_6791"/>
    </dbReference>
    <dbReference type="GeneID" id="41363981"/>
    <dbReference type="KEGG" id="mxa:MXAN_6791"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_7"/>
    <dbReference type="OMA" id="NHICTIR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="14"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="337" mass="35403" checksum="7411D9E15719ABEB" modified="2006-07-11" version="1">MGATMKRWQAKQAGRGHLELAEVAIPAPGAGEVLIRVSAVSLNYREKLMLDGGGYLTAHQPFTPASDMAGVVVAAGAGVQRFKEGARVIANFQTDWVDGPVPRGTVRSLGGNAPGVLAEYVVMPEQWLVASPETLDDVQASTLPCAGLTAWTSLVELGGLRPGHTVVTQGTGGVSLFAVQLAAAMGAEVIVLSGDEDKLARVKALGAAHGIHRRHTPEWHTAVLELTRGAGADHILELVGGDNLGRSVKALASDGRVSLIGVFEGFESRFPVQPLFMSSGVIQGIFVGHRRGLENLVRAVDRLALKPVVDTVYSLDALPTALEHLDRGPFGKLVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXJ2</accession>
    <name>Q1CXJ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556689.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6763"/>
    <dbReference type="EnsemblBacteria" id="ABF86266">
        <property type="protein sequence ID" value="ABF86266"/>
        <property type="gene ID" value="MXAN_6763"/>
    </dbReference>
    <dbReference type="GeneID" id="41363954"/>
    <dbReference type="KEGG" id="mxa:MXAN_6763"/>
    <dbReference type="eggNOG" id="ENOG5032ZFU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153689_1_0_7"/>
    <dbReference type="OMA" id="EFVVDFI"/>
    <dbReference type="OrthoDB" id="1968538at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10983" checksum="C96F595D8EACAF22" modified="2006-07-11" version="1">MADTPKPPDMQLQIQMDEDVANGQYVNMALVNHSDTEFTLDFIYVQPQQPKARVRSRIITNPKHMKRLVAAMQDNIQRYEAKFGPIAIPEEDGGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXK1</accession>
    <name>Q1CXK1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90212">
        <property type="protein sequence ID" value="ABF90212"/>
        <property type="gene ID" value="MXAN_6755"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6755"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111582_0_0_7"/>
    <dbReference type="OMA" id="YDMRDEY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="191" mass="21314" checksum="EC5EF71E12C035E5" modified="2006-07-11" version="1">MELKTPISATAPTLQPMSFQGIEVIGQSILAIVNGMELAQSRALRILGENGIAPLKADAWYPMPALLKSFRLVFDKIGPSTVRTIGRKIPDSAHFPPDIDTLEKGLRAVDMAYRMNHRGKGAIGGYRFEPVDKRNARMVCDNPYPCDLDLGLIEAIGDRFRPKDSLWVRIEHEAKSCRRRGDSACTYSINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXN1</accession>
    <name>Q1CXN1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556650.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6725"/>
    <dbReference type="EnsemblBacteria" id="ABF92127">
        <property type="protein sequence ID" value="ABF92127"/>
        <property type="gene ID" value="MXAN_6725"/>
    </dbReference>
    <dbReference type="GeneID" id="41363918"/>
    <dbReference type="KEGG" id="mxa:MXAN_6725"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330583_0_0_7"/>
    <dbReference type="OMA" id="GWRTLEV"/>
    <dbReference type="OrthoDB" id="406385at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187972" evidence="2">
        <location>
            <begin position="30"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="860"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="949" mass="97876" checksum="93C82EAE6733234C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ4</accession>
    <name>Q1CXZ4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556537.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6611"/>
    <dbReference type="EnsemblBacteria" id="ABF88639">
        <property type="protein sequence ID" value="ABF88639"/>
        <property type="gene ID" value="MXAN_6611"/>
    </dbReference>
    <dbReference type="GeneID" id="41363809"/>
    <dbReference type="KEGG" id="mxa:MXAN_6611"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054927_3_1_7"/>
    <dbReference type="OMA" id="ARDDHLY"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="32629" checksum="D5BDBC6D0160F880" modified="2006-07-11" version="1">MLLDAQTLARLQGVKLRARAVMEGVLSGLHKSPHQGQSVEFAEHKEYAPGDELRHLDWKAYGKFDKYYVKRFEHETNLRAVMVVDASASMGYRSGALSKLDVATTLAGALCYLLVRQQDAAGLALMAGGKWKDVPPRASAGHLNVLLDTLEHTEPTGTTDLGSAADHLAEVLPRRSSVIVLSDLLDENQDALRRILALRQRKNDVSVFHLVDPAELTFPFDDPTLFIDMEGQGRIEVNPREIKESYLEEFNAFLANVKAACAEADVDYDLVRTDDKLDDVLLRYLSRRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY34</accession>
    <name>Q1CY34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556497.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6567"/>
    <dbReference type="EnsemblBacteria" id="ABF87095">
        <property type="protein sequence ID" value="ABF87095"/>
        <property type="gene ID" value="MXAN_6567"/>
    </dbReference>
    <dbReference type="GeneID" id="41363772"/>
    <dbReference type="KEGG" id="mxa:MXAN_6567"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073333_0_0_7"/>
    <dbReference type="OMA" id="MFRHQGK"/>
    <dbReference type="OrthoDB" id="1751020at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="27300" checksum="17FE5F4F6FCCE772" modified="2006-07-11" version="1">MLASGIAMPFSSESSPGNRRAYTLLSLLLAGVAGLVNTTGFVALGLHTSHMSGSMATLGESLASGNVALAWLAAQLLLSFVVGAVSASVLLEASRQRPRGRHSSALLLEALTLGGIGAWLSYHPSTHEPTLMWGLAYAMGLQNALVTRVSGAVVRTTHITGILTDIGIQVVRLGSWLREGTRGQGLLGLRRRLWALPTAVEFERTRLHLGLGSAFLGGCTLGPMLFARLGAATLAIPCGVLVMLVALDLSAVATSGPQAMPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY78</accession>
    <name>Q1CY78_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MgtC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556453.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6522"/>
    <dbReference type="EnsemblBacteria" id="ABF92394">
        <property type="protein sequence ID" value="ABF92394"/>
        <property type="gene ID" value="MXAN_6522"/>
    </dbReference>
    <dbReference type="GeneID" id="41363730"/>
    <dbReference type="KEGG" id="mxa:MXAN_6522"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_1_4_7"/>
    <dbReference type="OMA" id="AANLWLT"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="17182" checksum="2CA57FD24460BC29" modified="2006-07-11" version="1">MDEQIVALRLALAALLGGVLGLEREVRGQAAGLRTHILVSLGACCFTLASVFIEVALGPDTPEGTRGDISRIASQVVVGIGFLGAGVILRHNGQVKGLTTAANLWLTASVGLAAGLGFYFAAVTTMTIALLCLAGLRPLERAIRRYRKRRSATRAPDVDEDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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        <property type="entry name" value="OEP"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYH6</accession>
    <name>Q1CYH6_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
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    </protein>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
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                <person name="Sullivan S.A."/>
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            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
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    </dbReference>
    <dbReference type="CDD" id="cd04792">
        <property type="entry name" value="LanM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017146">
        <property type="entry name" value="Lanti_2_LanM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037228">
        <property type="entry name" value="Lant_mod_RumM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03897">
        <property type="entry name" value="lanti_2_LanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="236"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118312" checksum="C988E317D3183081" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA3</accession>
    <name>Q1CZA3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RibD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556083.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6138"/>
    <dbReference type="EnsemblBacteria" id="ABF90699">
        <property type="protein sequence ID" value="ABF90699"/>
        <property type="gene ID" value="MXAN_6138"/>
    </dbReference>
    <dbReference type="GeneID" id="41363369"/>
    <dbReference type="KEGG" id="mxa:MXAN_6138"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_3_7"/>
    <dbReference type="OMA" id="TMLYWET"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20603" checksum="C5468C1E42FBD940" modified="2006-07-11" version="1">MGLLTFSINVTLDGCVDHQEGIADNETHAFFTRLMDEGGAMLWGRVTYEMMESYWPAVARGDEEAPPAMREWAVKLEAKPKYVVSSTRKDFPWTNSHHIAGDLRTGVQKLKDATPAGVLLGSGKLATELDRLDLIDEYKFLVHPRIAGHGPTLYQSGLPSTRRLELLSAKPLRSGAVAMHYRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE6</accession>
    <name>Q1CZE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6092"/>
    <dbReference type="EnsemblBacteria" id="ABF88134">
        <property type="protein sequence ID" value="ABF88134"/>
        <property type="gene ID" value="MXAN_6092"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6092"/>
    <dbReference type="HOGENOM" id="CLU_087589_0_0_7"/>
    <dbReference type="OMA" id="FHVGQAY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30405" checksum="22D10CD8A5FDAD8F" modified="2006-07-11" version="1">MFPPDADAAPFLLQRPAALQWLNARIRTRPTTAAPGGSVPTAFQTAVERKRPMPLPLRPAPLLLLCALLVPAAASAQRVTVPVDVGVGPAAFAFFGPVFDDQPIHTGLKLSVEAVLDKEWMKKNQRRVPPRYRKYAKSLDEVRISPSILIPDALIISPKLRNTGMYGATWKPLSLGVPLTSSPARLSLGAGLLLTYVYMHSDTLPNTHFLRPGAEVGIDLELQLSKSFLLGVGWESAFYVPQELGGLGLPERLRDGIFHVGQAYLQLHFRFPYTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZF5</accession>
    <name>Q1CZF5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556032.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6083"/>
    <dbReference type="EnsemblBacteria" id="ABF89127">
        <property type="protein sequence ID" value="ABF89127"/>
        <property type="gene ID" value="MXAN_6083"/>
    </dbReference>
    <dbReference type="GeneID" id="41363319"/>
    <dbReference type="KEGG" id="mxa:MXAN_6083"/>
    <dbReference type="eggNOG" id="COG4531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042661_1_0_7"/>
    <dbReference type="OMA" id="TYLWFSQ"/>
    <dbReference type="OrthoDB" id="1778971at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="414" mass="46516" checksum="817EBCC127CE9986" modified="2006-07-11" version="1">MSPPVTNSHTNFGPYTGTPKLMVPAFAVGILCLLATLGGFFATDAKGETAHAYLIGFTYWVGISVAFLIMQAIFHTAKAKWLIVLRRTMETASAVIPVFFVLALPLLAMATYLYPWWEGSELTKGYSSLELEHLSHKQHGYLNNHLSFPPGVGIRHIIYFGVWTFAAWRLRSWSLKQDTEGGLDFTVKQRKFSPGVLPFLALTITFASFDWLMSLTPLWQSTIFGVYYFAGSFLAAFCILTIVTVSAQGKDLYGSVVKLDHFHNLGKLMLAFTAFWAYIAFSQFMLVWIANIPEEAPWYGLRMFGPWRSMSIALFFLHFLLPFGILLSRKLKLQPRKLAVVAVYLLIIHAVDLYWLVWPALTGDAGPTFHWSLLTAFFGVGGIAVGFALYLARGHYTLTVKDPYIAESLRYVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZJ1</accession>
    <name>Q1CZJ1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Flavocytochrome MsrQ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msrQ</name>
        <name evidence="9" type="ORF">MXAN_6047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="7">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MsrQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555996.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6047"/>
    <dbReference type="EnsemblBacteria" id="ABF86982">
        <property type="protein sequence ID" value="ABF86982"/>
        <property type="gene ID" value="MXAN_6047"/>
    </dbReference>
    <dbReference type="GeneID" id="41363285"/>
    <dbReference type="KEGG" id="mxa:MXAN_6047"/>
    <dbReference type="eggNOG" id="COG2717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080662_0_1_7"/>
    <dbReference type="OMA" id="LHFFWMR"/>
    <dbReference type="OrthoDB" id="1508607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01207">
        <property type="entry name" value="MsrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022837">
        <property type="entry name" value="MsrQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36964">
        <property type="entry name" value="PTHR36964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="44"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22629" checksum="45E008B1225BFD90" modified="2006-07-11" version="1">MASSPYPWLNPALVVGGLSPLLMLAVQGPRGELGPNAIEAALHQTGLLTLVLLVASLTCTPLRLVAGWTWPARVRRTLGLLAFTYAVAHFLVYAVLDQGLAWGALWADVTERPFITVGFAALVLLVPLAVTSTNRWVRRLGFPRWQRLHRLAYGAAALGVVHFVWRVKKDVTEPLIYGAVLALLMAIRVGEAMRKRRARAAAAARNPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZL3</accession>
    <name>CLPS_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name type="ordered locus">MXAN_6025</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555974.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZL3"/>
    <dbReference type="SMR" id="Q1CZL3"/>
    <dbReference type="STRING" id="246197.MXAN_6025"/>
    <dbReference type="EnsemblBacteria" id="ABF87400">
        <property type="protein sequence ID" value="ABF87400"/>
        <property type="gene ID" value="MXAN_6025"/>
    </dbReference>
    <dbReference type="GeneID" id="41363263"/>
    <dbReference type="KEGG" id="mxa:MXAN_6025"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134358_0_0_7"/>
    <dbReference type="OMA" id="NDDYTSM"/>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000022612" description="ATP-dependent Clp protease adapter protein ClpS">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="107" mass="12079" checksum="42012BB5B30F4017" modified="2006-07-11" version="1">MAQKHEHDTSVITESAPKQKLKKPPLYKVLLHNDNYTTREFVVAVLKEVFHKSETDAVQIMLHVHYNGVGVAGVYTYDVAETKIQTVEAAAQENDMPLRLSMEPEEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW4</accession>
    <name>TAL_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transaldolase</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tal</name>
        <name type="ordered locus">MXAN_5922</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555873.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZW4"/>
    <dbReference type="SMR" id="Q1CZW4"/>
    <dbReference type="STRING" id="246197.MXAN_5922"/>
    <dbReference type="EnsemblBacteria" id="ABF91410">
        <property type="protein sequence ID" value="ABF91410"/>
        <property type="gene ID" value="MXAN_5922"/>
    </dbReference>
    <dbReference type="GeneID" id="41363160"/>
    <dbReference type="KEGG" id="mxa:MXAN_5922"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_7"/>
    <dbReference type="OMA" id="VRHPMHV"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000126331" description="Probable transaldolase">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <sequence length="223" mass="24082" checksum="93AC912A6F05CE86" modified="2006-07-11" version="1">MKFFIDSADVEEIRKAHAMGCVDGVTTNPSLLAKVGRGLEETIREICSIVDGPISAECVSMEADELIKEGRSLAKIHDNVVVKIPMGVEGMKATKALTAEGIRTNVTLCFSANQALLCAKAGATYVSPFVGRLDDISQDGMELISHILEIYRNYEHFNTQVLVASVRNPVHVLQAARLGADVATLPYNVITQLANHPLTDAGIKKFLADWEKVPKAAKPPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C8</accession>
    <name>Q1D0C8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopenicillin N epimerase</fullName>
            <ecNumber evidence="3">5.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cefD</name>
        <name evidence="3" type="ORF">MXAN_5758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555709.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5758"/>
    <dbReference type="EnsemblBacteria" id="ABF88816">
        <property type="protein sequence ID" value="ABF88816"/>
        <property type="gene ID" value="MXAN_5758"/>
    </dbReference>
    <dbReference type="GeneID" id="41363001"/>
    <dbReference type="KEGG" id="mxa:MXAN_5758"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_3_1_7"/>
    <dbReference type="OMA" id="TGNCHKW"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045439">
        <property type="term" value="F:isopenicillin-N epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="394" mass="43276" checksum="799AF9FC0119AD84" modified="2006-07-11" version="1">MSAPFRSHWSLDPEVVFLNHGSFGACPTAVLQRQSELRARLEAEPVRFLHREIEPLLDDARAALATFVGADADDLGFVPNATAGVSTVLRSLRFAPGDELLTTDHEYNASRNALDFVASQWGAKVVVAKLPWPVPSAQSVVDAVLPHVTPRTRLFLVDHVSSQTALVMPLEQLVAALRERGVETLVDGAHGPGMLPLSLRTLGAGYYTGNCHKWMCAPKGAAFLHVRRDLQSAIKPLSVSHGHNSRRTDRSRFRLDFDWTGTHDPSAVLCVPEVIRFMGGLLPGGWPEVMASNRAKVLAAQNLLCARLGTQPTCPEDMVGSMATVTLPDGFPEVPQPPLYVDPLHLRLFDEYRIEAQITPWPRPPHRHVRLSAQLYNTPADYQALGDALEALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J8</accession>
    <name>Q1D0J8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555640.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5687"/>
    <dbReference type="TCDB" id="1.A.23.7.2">
        <property type="family name" value="the small conductance mechanosensitive ion channel (mscs) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92258">
        <property type="protein sequence ID" value="ABF92258"/>
        <property type="gene ID" value="MXAN_5687"/>
    </dbReference>
    <dbReference type="GeneID" id="41362932"/>
    <dbReference type="KEGG" id="mxa:MXAN_5687"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025726_0_0_7"/>
    <dbReference type="OMA" id="QNYKRLQ"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188074" evidence="6">
        <location>
            <begin position="27"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="552" mass="60645" checksum="00488D1F609CA15F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0M5</accession>
    <name>Q1D0M5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative batD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555613.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5660"/>
    <dbReference type="EnsemblBacteria" id="ABF90622">
        <property type="protein sequence ID" value="ABF90622"/>
        <property type="gene ID" value="MXAN_5660"/>
    </dbReference>
    <dbReference type="GeneID" id="41362905"/>
    <dbReference type="KEGG" id="mxa:MXAN_5660"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016843_1_0_7"/>
    <dbReference type="OMA" id="CEFARYA"/>
    <dbReference type="OrthoDB" id="997498at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025738">
        <property type="entry name" value="BatD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40940">
        <property type="entry name" value="PTHR40940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13584">
        <property type="entry name" value="BatD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188231" evidence="2">
        <location>
            <begin position="26"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="624" mass="67240" checksum="608C1276EA213B4D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T3</accession>
    <name>Q1D0T3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="5 12">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ddl</name>
        <name evidence="16" type="ORF">MXAN_5601</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="5 12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555555.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5601"/>
    <dbReference type="EnsemblBacteria" id="ABF90004">
        <property type="protein sequence ID" value="ABF90004"/>
        <property type="gene ID" value="MXAN_5601"/>
    </dbReference>
    <dbReference type="GeneID" id="41362847"/>
    <dbReference type="KEGG" id="mxa:MXAN_5601"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_2_0_7"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="114"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="318" mass="33573" checksum="8D75646553A735D6" modified="2006-07-11" version="1">MTPNRGAFTKDELKQKRVGVLLGGMSAERDVSLRTGEAVSGALRGLGYDVVEIDVGRDLPARLAAEKVDVAWLAVHGRYGEDGCLQGLLESLFIPYTGSGVLASALGMDKVYAKQVYVAHGIPTPAYRSFKDAASALAAADSLPFPFPVVVKPSREGSSVGVHICKTRDAYEAAVTDAAKYAGTLLVEQFVKGREVQGGVLDDEALGVIEVRAAREFYDYDAKYKAGTGTQYLFPAPLPPDQYARVNEVCLAAHQALGCSGGSRSDVIVTDGGDVFLLETNTLPGMTASSLLPKIAAGRGIDFPALCERLLLGACLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1L1</accession>
    <name>Q1D1L1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555277.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85991">
        <property type="protein sequence ID" value="ABF85991"/>
        <property type="gene ID" value="MXAN_5311"/>
    </dbReference>
    <dbReference type="GeneID" id="41362581"/>
    <dbReference type="KEGG" id="mxa:MXAN_5311"/>
    <dbReference type="eggNOG" id="COG5612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1659685_0_0_7"/>
    <dbReference type="OMA" id="RTHGRWA"/>
    <dbReference type="OrthoDB" id="1753043at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025961">
        <property type="entry name" value="Metal_resist"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13801">
        <property type="entry name" value="Metal_resist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20540" checksum="AA632A9EC2109A1C" modified="2006-07-11" version="1">MFGFLFGTACLAGLIYTVRGGRHGYRRGGRWSSRGRLRWLFERLDTSPGQEKVLLKAADDVMEAFAKARDEVGPSRTALGAALRGEHFDGAALRELFARHDVAIDNVRRTVQGSLAQVHEALDPRQRRELADLLEHGFGSAYGWHGGHGGWHRRCGGPGGWRGGGFGHGGHRHGDGHGPWGRDDARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1N4</accession>
    <name>Q1D1N4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555254.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5287"/>
    <dbReference type="EnsemblBacteria" id="ABF87287">
        <property type="protein sequence ID" value="ABF87287"/>
        <property type="gene ID" value="MXAN_5287"/>
    </dbReference>
    <dbReference type="GeneID" id="41362561"/>
    <dbReference type="KEGG" id="mxa:MXAN_5287"/>
    <dbReference type="eggNOG" id="ENOG50327MX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1794426_0_0_7"/>
    <dbReference type="OMA" id="RESYHVE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19521" checksum="A01CF0CAA4D87A98" modified="2006-07-11" version="1">MDAPARASRPEHGRGGLVQRLHRERDPFHLKVHPMLRFVSSALVVVLSTGCASSTVIRSSPSGAKVRSRSGEVLGRTPYEYSDSATVNNTESFTLELDGHAPEYVTIRRDQWSGARTAGGIVGGLFVFPVFATLFWAADYRESYHVELTALPDSEPEAPAPPVRARRTSSEKSPTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T2</accession>
    <name>Q1D1T2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5239"/>
    <dbReference type="EnsemblBacteria" id="ABF90298">
        <property type="protein sequence ID" value="ABF90298"/>
        <property type="gene ID" value="MXAN_5239"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5239"/>
    <dbReference type="HOGENOM" id="CLU_1203790_0_0_7"/>
    <dbReference type="OMA" id="ANWPPAR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="230" mass="23524" checksum="A81EA0450484D5C9" modified="2006-07-11" version="1">MSGGIEMMARLMRVLVMGLVWMPLLARGQGLSKEEVREPPVDMASQSSTESPPTASPMQGSGVAADDDYSLGGHLVVGTLLGGVGLFTGTLVGGLVGAVLDSDCPLTRCGDTFAFAIPMSLGTALGTSLAIYLTGDKFNGRGNFGPTFLGAALGAVPFALLTTSRHDRVARIGTVGMLVTPLIGSFTGYWLSRSPSPSRGTARAELPEAQAAPVLGLTRGGGLVGVMGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T6</accession>
    <name>Q1D1T6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5235"/>
    <dbReference type="EnsemblBacteria" id="ABF90806">
        <property type="protein sequence ID" value="ABF90806"/>
        <property type="gene ID" value="MXAN_5235"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5235"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996873_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="31467" checksum="6513753486672E19" modified="2006-07-11" version="1">MSRARSLPECWNHGLALAMDAVRINTVSLEVRRGVSLWHKQRRLGMGAVIAVGNVFLHLSRSRIRMHPSVSRWRGRELASFALLHPGRLAEPCGGRAVVLEALPGERLDRLLQQGRLTPNIMEAAARELHRAHGLTLPGASRAWSHGDVHLKNLLYDEVKQRAWLIDFETEHDTSLDASERHADDLLVLLLDLRGRAPLEQARSLAEAFLRAYPEQTVRRELTSRLCPPRGLERALWKSRSHHLPDEALIDWLEYLQAAVEPRLKKGHVPGKVVSLPPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D290</accession>
    <name>RS18_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">MXAN_5079</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555053.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D290"/>
    <dbReference type="SMR" id="Q1D290"/>
    <dbReference type="STRING" id="246197.MXAN_5079"/>
    <dbReference type="EnsemblBacteria" id="ABF90687">
        <property type="protein sequence ID" value="ABF90687"/>
        <property type="gene ID" value="MXAN_5079"/>
    </dbReference>
    <dbReference type="GeneID" id="41362363"/>
    <dbReference type="KEGG" id="mxa:MXAN_5079"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_0_2_7"/>
    <dbReference type="OMA" id="FCAEKNA"/>
    <dbReference type="OrthoDB" id="1939104at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000345514" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="131" mass="13583" checksum="99B35F6341F4754D" modified="2006-07-11" version="1">MSNGTDSKTASAPPARSGGGFGGGGSRGGDRGDRGDRGGDRGDRGGGLGGDDDKRGGGRGFGRKKVCRFCAEKNASVDFKDQATLKYFVTERGKIIPRRISGNCAKHQREVAVAIKRARGIALLPYNAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2I1</accession>
    <name>Q1D2I1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4986"/>
    <dbReference type="EnsemblBacteria" id="ABF92024">
        <property type="protein sequence ID" value="ABF92024"/>
        <property type="gene ID" value="MXAN_4986"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4986"/>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318275_0_0_7"/>
    <dbReference type="OMA" id="EIHAHGA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="841"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="998" mass="108713" checksum="5D7CBA4AAE741365" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2J4</accession>
    <name>RUVC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvC</name>
        <name type="ordered locus">MXAN_4973</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554951.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D2J4"/>
    <dbReference type="SMR" id="Q1D2J4"/>
    <dbReference type="STRING" id="246197.MXAN_4973"/>
    <dbReference type="EnsemblBacteria" id="ABF86200">
        <property type="protein sequence ID" value="ABF86200"/>
        <property type="gene ID" value="MXAN_4973"/>
    </dbReference>
    <dbReference type="GeneID" id="41362258"/>
    <dbReference type="KEGG" id="mxa:MXAN_4973"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_2_1_7"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000071033" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <sequence length="191" mass="19826" checksum="90121E16C2AE4515" modified="2006-07-11" version="1">MRVLGVDPGSRFMGFGVVEEKRGRLVHVGHGVIKGDPALPLSDRLRDLHGALTAALVKYRPAAVAVEGVFTFRNARSALVLGHARGVALLAAAQAGLPVFEYAPAKVKKAVGAGGADGKDAVARMVRTFLELDASVLERADASDALAVALCHLNHGRAAVPAASASGKKRKGAAALLADRLAPAYRRPEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2T4</accession>
    <name>Q1D2T4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554864.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4882"/>
    <dbReference type="EnsemblBacteria" id="ABF92422">
        <property type="protein sequence ID" value="ABF92422"/>
        <property type="gene ID" value="MXAN_4882"/>
    </dbReference>
    <dbReference type="GeneID" id="41362172"/>
    <dbReference type="KEGG" id="mxa:MXAN_4882"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083277_0_0_7"/>
    <dbReference type="OMA" id="TRHGTPE"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016538">
        <property type="entry name" value="UCP008292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008292">
        <property type="entry name" value="UCP008292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25399" checksum="AB7F3E09FE89B8D2" modified="2006-07-11" version="1">MAAVGDLHCREDHHGRFRQLVKQVNATADLLVLCGDLTDRGMIEEGKVLAEELSALRVPCAAVLGNHDYEHNQVKEICSELAKVGVHVLDGDHFIFEKVLGVAGVKGFGGGFGNATLQAFGEGQTKAFVQEAVTESLKLEAALSHLDVEKKVVIMHYAPVPDTLEGENIEIRPFLGTSRLSMPIDHYGAEAVFHGHAHHGARNGKTKSGIPVYNVAMPLLAKHTPDQRYVLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2T5</accession>
    <name>Q1D2T5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554863.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4881"/>
    <dbReference type="EnsemblBacteria" id="ABF89214">
        <property type="protein sequence ID" value="ABF89214"/>
        <property type="gene ID" value="MXAN_4881"/>
    </dbReference>
    <dbReference type="GeneID" id="41362171"/>
    <dbReference type="KEGG" id="mxa:MXAN_4881"/>
    <dbReference type="eggNOG" id="ENOG5032VJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546079_0_0_7"/>
    <dbReference type="OMA" id="VITSEHP"/>
    <dbReference type="OrthoDB" id="497448at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="90"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="244"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="391"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="55124" checksum="19554FAB98100EAD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2V3</accession>
    <name>Q1D2V3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ABF88530">
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        <property type="gene ID" value="MXAN_4861"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4861"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="32" mass="3449" checksum="EA1F7D7FDF0B5AF6" modified="2006-07-11" version="1">MSTPPGRLLGHEIHPSRKQTAGAEAIATFMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z0</accession>
    <name>Q1D2Z0_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4822"/>
    <dbReference type="EnsemblBacteria" id="ABF90682">
        <property type="protein sequence ID" value="ABF90682"/>
        <property type="gene ID" value="MXAN_4822"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4822"/>
    <dbReference type="HOGENOM" id="CLU_1004088_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="29000" checksum="463CEF91443A9E9D" modified="2006-07-11" version="1">MKQGATRESQKPTPSRAVGFPETAQPGHSGHWRTDAHRGCRTAATRLVGRARHQSPHDAPAPAALSTRPPEPSRNTPLPFHPAATVRWCFTPDESGGLSGRARVVSGSGQLPRAHAVTHGTVFTRVLTHELPFSMLVAAARQRPGDAHAAGAAPSRGARGLAGGRHRGADARAGRPTLPRPPAARAGVHRPHRRGARNGGATRDSRLGRRGESLRAADVVRRGGPHAQCLPGPPRATPQQPSLVPEQDTPRRGLGAAGRSPGGNVRRGAPCPASGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D301</accession>
    <name>Q1D301_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4811"/>
    <dbReference type="EnsemblBacteria" id="ABF86980">
        <property type="protein sequence ID" value="ABF86980"/>
        <property type="gene ID" value="MXAN_4811"/>
    </dbReference>
    <dbReference type="GeneID" id="41362110"/>
    <dbReference type="KEGG" id="mxa:MXAN_4811"/>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028593_2_1_7"/>
    <dbReference type="OMA" id="VPSMTIM"/>
    <dbReference type="OrthoDB" id="140284at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="583" mass="65456" checksum="9FECE0537803CAFB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D307</accession>
    <name>Q1D307_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4805"/>
    <dbReference type="EnsemblBacteria" id="ABF89883">
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        <property type="gene ID" value="MXAN_4805"/>
    </dbReference>
    <dbReference type="GeneID" id="41362104"/>
    <dbReference type="KEGG" id="mxa:MXAN_4805"/>
    <dbReference type="eggNOG" id="COG3913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="YGWMEAG"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017748">
        <property type="entry name" value="TagF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038225">
        <property type="entry name" value="TagF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09867">
        <property type="entry name" value="TagF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03373">
        <property type="entry name" value="VI_minor_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="33228" checksum="5CBCC27B64D537D7" modified="2006-07-11" version="1">MAVQSPRIGLLGKTPRQAEFIRHNAATPLALQLYGWMEAGVERSRRARVDLPAEPVCFVFTAPGQKQALVGLMAPSQDSVGRAFPLAVFTEVSSAETASRLALTPEAYQPFLRAAGALAQSAAELEVPQLLERVAALPLPGPGDYSLAKRLLNAVLADHHTVDLLGPVVEGTPEGGRYYALHTFLTACAGERGKEQSPAGVTLDCPLTTRVGPVAWLELSSRLLKWTHQPPAFFWSEGEKPRLLISLGAASPALFLALAQPSRPGAQVWPLRTERPAAIDNARKGLTASARQVIDAPSTTLEQLLQTLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3F4</accession>
    <name>Q1D3F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554645.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4653"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89183">
        <property type="protein sequence ID" value="ABF89183"/>
        <property type="gene ID" value="MXAN_4653"/>
    </dbReference>
    <dbReference type="GeneID" id="41361953"/>
    <dbReference type="KEGG" id="mxa:MXAN_4653"/>
    <dbReference type="HOGENOM" id="CLU_1141602_0_0_7"/>
    <dbReference type="OMA" id="AAWKWMV"/>
    <dbReference type="OrthoDB" id="1551009at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188325" evidence="1">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="25084" checksum="3B924EBF76958C84" modified="2006-07-11" version="1">MAQAAWKWMVVAAAVGAGVLACDGGGGNKPPPSHGVDAGVNVFRPGLGEDDGAPQGTPLSLPEGVSFAGTLRGAAEVSGECENASVESQGSGALVRVCVPLRNDTGAPVEVEFPPGLVVVSTSEGRGQNGLLIERTILVVPPTRPGPGGRDDAGTPDGGVEENVYIVPLYMYCLNEERDPSNEFMTYAVGPITSDDALQELLRLLEGKVIDSSEDVGVVQNALYSITEGRGLTTPDRDAINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z7</accession>
    <name>Q1D3Z7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glpX</name>
        <name evidence="6" type="ORF">MXAN_4455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554453.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4455"/>
    <dbReference type="EnsemblBacteria" id="ABF86404">
        <property type="protein sequence ID" value="ABF86404"/>
        <property type="gene ID" value="MXAN_4455"/>
    </dbReference>
    <dbReference type="GeneID" id="41361766"/>
    <dbReference type="KEGG" id="mxa:MXAN_4455"/>
    <dbReference type="eggNOG" id="COG1494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_7"/>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="OrthoDB" id="879338at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="34239" checksum="51F1B1308491618F" modified="2006-07-11" version="1">MDRNLAMEVVRVTEMAAIASARLMGRGNKDESDQAAVDAMRRAFDALQIDGTVVIGEGERDEAPMLYIGEKVGKRGEGAPEVDIALDPLEGTNLCAYGRPGSIAVVAMAGKGGLLNAPDTYMEKMAVGPRARGAIDLRKTPTENLRSIAEKMKVYVEDLTVVVLDRERHTDLIKEIRAAGARIRLIEDGDVAGAIATCFEDTGVEVLMGIGGAPEGVIAAAAIRATGGDMQGRLVPRNQGEIDRARSMGITDISKIYTAEELAKGEVMFAASGVTTGDFLKGVRFFGGGCETHSVVMRSKTGTVRFIQSVHKFDKKPGYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D410</accession>
    <name>Q1D410_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554441.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4442"/>
    <dbReference type="EnsemblBacteria" id="ABF88393">
        <property type="protein sequence ID" value="ABF88393"/>
        <property type="gene ID" value="MXAN_4442"/>
    </dbReference>
    <dbReference type="GeneID" id="41361754"/>
    <dbReference type="KEGG" id="mxa:MXAN_4442"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486461_0_0_7"/>
    <dbReference type="OMA" id="RTVAWQD"/>
    <dbReference type="OrthoDB" id="219557at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="598" mass="63066" checksum="44CA7A0AE6D1E4DC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4A9</accession>
    <name>Q1D4A9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase alpha (Molybdopterin) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_4341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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    <dbReference type="STRING" id="246197.MXAN_4341"/>
    <dbReference type="EnsemblBacteria" id="ABF88039">
        <property type="protein sequence ID" value="ABF88039"/>
        <property type="gene ID" value="MXAN_4341"/>
    </dbReference>
    <dbReference type="GeneID" id="41361653"/>
    <dbReference type="KEGG" id="mxa:MXAN_4341"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="DCSDLCH"/>
    <dbReference type="OrthoDB" id="50471at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="6">
        <location>
            <begin position="140"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="7">
        <location>
            <begin position="667"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="792" mass="85784" checksum="6EF545633747E9A8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D571</accession>
    <name>Q1D571_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554032.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4023"/>
    <dbReference type="EnsemblBacteria" id="ABF88225">
        <property type="protein sequence ID" value="ABF88225"/>
        <property type="gene ID" value="MXAN_4023"/>
    </dbReference>
    <dbReference type="GeneID" id="41361354"/>
    <dbReference type="KEGG" id="mxa:MXAN_4023"/>
    <dbReference type="eggNOG" id="ENOG5032NNU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1569047_0_0_7"/>
    <dbReference type="OMA" id="QEWMRFR"/>
    <dbReference type="OrthoDB" id="1456373at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="19452" checksum="639857C45D8DB79C" modified="2006-07-11" version="1">MGPVSAPDPRKDPRYRRFRGAAYGIYILVTTLFSLWLIWSVGHSVLAMTPEKLPPAPVALTFRECLDGARALWADLESGREKLVNVSPAKSVDQEWMRFRTAWLQKLRVRESECALDSRERAPLREVFRRLVRVQDLYAIHAVQYAGEVGGEVDALHDALNTAGRNPGAGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5F6</accession>
    <name>Q1D5F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase-like monooxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3937"/>
    <dbReference type="EnsemblBacteria" id="ABF90561">
        <property type="protein sequence ID" value="ABF90561"/>
        <property type="gene ID" value="MXAN_3937"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3937"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_3_5_7"/>
    <dbReference type="OMA" id="MIDESMY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="366" mass="41084" checksum="56BCA1C489AB62E3" modified="2006-07-11" version="1">MSLEELLGVRPPSQRRSQVSFSFLFFSDVRKDISSAEKYRFMRDVTLFGDAKGFTAVYIPERHFSEFGSIYANSAVMASYLIAQTKRIRFRTAGISLPLHHPAEVVEWWAMNDNLSGGRVDLGFGSGWAKPDFIYAPDAYEKRRAICAERIDIVRRLWRGETVPFPGPGGVDIPITVYPRPVQKELNVWLLITQNADAFAQAGRLGFNVFTMLYGCDLDVLRDRIALYRQARKEAGHDPETGIVSLMLHTLVHRDMALVRRAVEAPFKEYIRSSLDAHLAAGLGSAGKVSLKEIGEAEKNKILEYAYERYFSTGALFGDVGDARRMVEKTIAAGVNDIACLVDFGVDYPLVMESLPYLEKLVADYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D622</accession>
    <name>Q1D622_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3715"/>
    <dbReference type="EnsemblBacteria" id="ABF92469">
        <property type="protein sequence ID" value="ABF92469"/>
        <property type="gene ID" value="MXAN_3715"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3715"/>
    <dbReference type="HOGENOM" id="CLU_598287_0_0_7"/>
    <dbReference type="OMA" id="AWAPVHT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188305" evidence="2">
        <location>
            <begin position="34"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="521" mass="54373" checksum="13F4C21C25818925" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D652</accession>
    <name>Q1D652_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">treS</name>
        <name evidence="8" type="ORF">MXAN_3684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553702.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3684"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88853">
        <property type="protein sequence ID" value="ABF88853"/>
        <property type="gene ID" value="MXAN_3684"/>
    </dbReference>
    <dbReference type="GeneID" id="41361019"/>
    <dbReference type="KEGG" id="mxa:MXAN_3684"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_1_7"/>
    <dbReference type="OMA" id="PFQWTGG"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="15"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="551" mass="65070" checksum="16087907697FDE8B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6G5</accession>
    <name>Q1D6G5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2OG-FeII_Oxy_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553594.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3568"/>
    <dbReference type="EnsemblBacteria" id="ABF91457">
        <property type="protein sequence ID" value="ABF91457"/>
        <property type="gene ID" value="MXAN_3568"/>
    </dbReference>
    <dbReference type="GeneID" id="41360913"/>
    <dbReference type="KEGG" id="mxa:MXAN_3568"/>
    <dbReference type="eggNOG" id="ENOG502ZA3D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244151_0_0_7"/>
    <dbReference type="OMA" id="LRSYCKT"/>
    <dbReference type="OrthoDB" id="1064435at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OG-FeII_Oxy_3" evidence="1">
        <location>
            <begin position="107"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26884" checksum="27C75417F42C6018" modified="2006-07-11" version="1">MRAYITRREALPRSALHELRTALLGSRFVARSPLMGTFQASRGFAFIFTHEGRATLEARFPFLVPYLAHVLDPLHATGLLPWHERLWGSRRERPAPNAFYLNLLLLDAGRGVGRHIDATLQEPSGVPDATPRHVSVLYLQVPERAQGGELRLLQNDTPVGEIRPREGLLVHFRGDLQHEVRPFTGSQEGATRASLVCEQYVFPPEALARIPAFRIQSKAGFAAYLDHQREQPGGSSVGTLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N0</accession>
    <name>MNMA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="ordered locus">MXAN_3499</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553529.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6N0"/>
    <dbReference type="SMR" id="Q1D6N0"/>
    <dbReference type="STRING" id="246197.MXAN_3499"/>
    <dbReference type="EnsemblBacteria" id="ABF85898">
        <property type="protein sequence ID" value="ABF85898"/>
        <property type="gene ID" value="MXAN_3499"/>
    </dbReference>
    <dbReference type="GeneID" id="41360844"/>
    <dbReference type="KEGG" id="mxa:MXAN_3499"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_7"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000349710" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <sequence length="348" mass="37577" checksum="405480F83487E4EB" modified="2006-07-11" version="1">MRVVVAMSGGVDSSAAAALLKEQGHEVIGITLRVWSYEGKATCGSCCSPDDIDDARAVAQTLGIPFYVANAEEIFQDRVINPFVQSYLGGRTPIPCVACNRDVKFNFLLKRARALGARLATGHYARVEEVDGRFVLRRAVDAAKDQSYFLFTLGQDELRDILFPVGGMTKAEVRAVAERHGLVTSQKPESMEICFVPDGDYAGFVEKVAGPQPAGDIVDTEGNVLGTHQGIHRYTVGQRKGLNLGGGEIRYVHRLEPETQRVVVGPAEGTGRDNFGLLQPHWVDGPPPASQPVEVRIRHRHSGAQGRVHVSPHGLVSVKLDAPARAVTPGQAAVVYDQDRVLGGGWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N3</accession>
    <name>Q1D6N3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vegetative protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553526.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91945">
        <property type="protein sequence ID" value="ABF91945"/>
        <property type="gene ID" value="MXAN_3496"/>
    </dbReference>
    <dbReference type="GeneID" id="41360841"/>
    <dbReference type="KEGG" id="mxa:MXAN_3496"/>
    <dbReference type="HOGENOM" id="CLU_113693_0_0_7"/>
    <dbReference type="OMA" id="RVWVRKK"/>
    <dbReference type="OrthoDB" id="2054872at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="23559" checksum="3FE3ABDEDDC360A5" modified="2006-07-11" version="1">MPPLERAFRTVLAEELAGQLSPLTDTLLRIAESLSPSGLRRQPRRELPNAALDALASSLATLDTGPDDATEEEVAPEARACAVIGCKRPVRSLGYCAAHYQKRRLMVASGRLHHAWTEDAAPNSIPDVILGRKRRESSEAPETAVTPEPVRPSEGPRVWVRKKGASPVVPTPSGDSAPILQLAQASVIPTAQRSEREQVASIVEQWASEFRANKHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P4</accession>
    <name>Q1D6P4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, group 2</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553515.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3484"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89364">
        <property type="protein sequence ID" value="ABF89364"/>
        <property type="gene ID" value="MXAN_3484"/>
    </dbReference>
    <dbReference type="GeneID" id="41360831"/>
    <dbReference type="KEGG" id="mxa:MXAN_3484"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029695_4_2_7"/>
    <dbReference type="OMA" id="EIKFHFA"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="45"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="417" mass="47132" checksum="D47EEABAAD39EC3C" modified="2006-07-11" version="1">MELFPIQLLFMVVLMNRYVLGPLLRRLKGRKFDRVDDTYLPRVAIVIPLFNEGEGIYHGVRSLLEQDYPSHLLQIVVVDDCSKDDSYAWALKAAEGNPNVIVMRNPENMGKRKGINRAVKAATDAEIIVSVDSDVIVDKAAVRQLVRRFVSPRIAAVGGRTYVTNRHQNWMTRMIEIKFHFAQEWLKDLERSFRQVMCLSGCLTAYRRHVLLELEPILEARAIAGIPIKYGEDRFLTRQIVKHDYETVYTLDAFCFTAAPSTLAGYFSQQLRWRRSNLVDLLGGLSHAWRLHPVVAVHYVSQLALLLSYPLVIVHNVLTGEFWDILAFHFLVIGLLGVIYRIETRHLPADRRVHGASFLPMALLMPVTYALFTPLALLTLDSGSWETRGSANTAPETSPVDSGGRFPPTHAGEGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6R5</accession>
    <name>Q1D6R5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553494.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3461"/>
    <dbReference type="EnsemblBacteria" id="ABF86102">
        <property type="protein sequence ID" value="ABF86102"/>
        <property type="gene ID" value="MXAN_3461"/>
    </dbReference>
    <dbReference type="GeneID" id="41360808"/>
    <dbReference type="KEGG" id="mxa:MXAN_3461"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567205_0_0_7"/>
    <dbReference type="OMA" id="MRARPLM"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="53329" checksum="427E6BBB8F7E4E06" modified="2006-07-11" version="1">MTTHASHQGTYAVEHVLQRIRRCAADVTRYPVDILTADAQLEDELGIDSVKLAEIAAVVGREFNIPSERLPRGAQARTLGAMADVVARLLADTQPAAVATPPPAPVAAPVLQVSSAGSPVKDLEARVRAVFARVTRYPEELLTPEADLEDELGIDSVKQAEVMAVLIKELGLTDAPQPSQRLRTISSICEMARARLAVAAPVREDRAPRQSPPPAVLPFAGKVAFVTGSGKGIGKVIAARLAGSGATVVVNSFHSRDEGERTVQEIVDAGGKAFHAWGSVAQEEHLDRMFASIEAQFGGLDFLVCNASNGLIGPFDRITPRDWDKAFRTCITGTYECAMRARPLMARRGGGSIVTMSTSMSQRYMHDLGCQGVVKAGVESLTRYLAAELAPDGIRTNCVSAGPVHGELLRMFPDAASRVARWESATPGGEICTAEDVADVTELLLGPKTRRVNGAIWVVDAGLSGTVDGLLPGASEARRSEAQRGSHRSEHDLRALLALDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6V0</accession>
    <name>Q1D6V0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553459.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D6V0"/>
    <dbReference type="STRING" id="246197.MXAN_3426"/>
    <dbReference type="EnsemblBacteria" id="ABF90558">
        <property type="protein sequence ID" value="ABF90558"/>
        <property type="gene ID" value="MXAN_3426"/>
    </dbReference>
    <dbReference type="GeneID" id="41360773"/>
    <dbReference type="KEGG" id="mxa:MXAN_3426"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_3_7"/>
    <dbReference type="OMA" id="WLFQIAN"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="22606" checksum="E1BBFFA8BE9299D4" modified="2006-07-11" version="1">MSDMNQGAGAESDGVVRPLSADVISSLVENHREFLRFLERRVGSRAVAEDILQDAFVRGMGKAETLREDESLTAWFYSVLRNAVIDHYRRRGTTERALASLASELEEGHAPEAELAQAVCQCVGRLAGTLKPEYAEALRRVEVEGVSVPAFALEAGITSNNAAVRLHRARKALKKQLEVSCGTCASHGCLDCTCATQGAEKKAGGCGSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X8</accession>
    <name>Q1D6X8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553431.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3398"/>
    <dbReference type="EnsemblBacteria" id="ABF93079">
        <property type="protein sequence ID" value="ABF93079"/>
        <property type="gene ID" value="MXAN_3398"/>
    </dbReference>
    <dbReference type="GeneID" id="41360745"/>
    <dbReference type="KEGG" id="mxa:MXAN_3398"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_7"/>
    <dbReference type="OMA" id="RWMLGYD"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="40573" checksum="E973ECC29E85EFA9" modified="2006-07-11" version="1">MSTSSPRHVLVAGAGIGGLTLACALRRAGLSVTVFERSDALKWVGAGLTVQMNASAALRRIGLCDEVAQAGACPTDSAILKPSGSALTRLPVTRIQEELGLPLVCVHRARLQSVLMAHAGEENVRLGLTVTAFHDDGQTVTVRLSDGSSVTGDALVGADGLRSVVRGALLGDAPLRYSGYTSWRGVCPDVPSATPGLVSETWGRGARFGVVPIGFGQTYWFATQNAPAGEQDAPGETRARLQSLFGGWHAPIADLIAATDEANIIRTDIHDRPPASRWSRGRVTLLGDAAHPMTPNMGQGGCQAIEDAVVLAELLAGEGPVDAALAAYEQRRLGRANSFVTRSWSLGRVAQWESSAGRFIRNALFQLVPQGFAARQVRALVRDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Y1</accession>
    <name>Q1D6Y1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">MXAN_3395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553428.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3395"/>
    <dbReference type="EnsemblBacteria" id="ABF88619">
        <property type="protein sequence ID" value="ABF88619"/>
        <property type="gene ID" value="MXAN_3395"/>
    </dbReference>
    <dbReference type="GeneID" id="41360742"/>
    <dbReference type="KEGG" id="mxa:MXAN_3395"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_5_2_7"/>
    <dbReference type="OMA" id="ILYPMRI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="22187" checksum="F13CB527A5DD1811" modified="2006-07-11" version="1">MVLKIVQAGDPVLRRKARDLTPEEIASPETARLIEQMRDTMRDAPGVGLAAPQVGVGLRVVVIEDRPEYQAGLSESERAARGRKPVPFHVLINPRLVVEDAAPAEFHEGCLSVSGFAALVPRACAVRVDALDEHGQPVTVQARGWYARILQHELDHLDGTLYVDRMETRSFTTAENHRRYQAGRSTEELRAELGLPVPDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D745</accession>
    <name>Q1D745_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553364.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3329"/>
    <dbReference type="EnsemblBacteria" id="ABF90906">
        <property type="protein sequence ID" value="ABF90906"/>
        <property type="gene ID" value="MXAN_3329"/>
    </dbReference>
    <dbReference type="GeneID" id="41360682"/>
    <dbReference type="KEGG" id="mxa:MXAN_3329"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594240_0_0_7"/>
    <dbReference type="OMA" id="RAVDQYM"/>
    <dbReference type="OrthoDB" id="357254at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="459" mass="50611" checksum="E6C39722EA86BCA6" modified="2006-07-11" version="1">MTIRHLRSRPWIRAAVLGVGLLTGCSTTSSNSAKARPTDPLSQARAYLDEHQPTKALRLLTDLHRQTPDDLDVARSLTEAYVKAGQTDAWIAELQKRIAAGERAVDQYMLGLALFSRARDAGAPSVAAFERAATLAPDTAEFHYRLGLAQLESEQYTEALGPLRRATALEPARTAWRLPLAKALHRTGDAPGAVEALGTVVRGQPTAADVTTARALMEQIADPFSGFPKAAEAKLEEGMRYLKDLDAPQHAILAFEEILLDYPDVAVVHALLGLAYQRLDDAGRAVDEFKQAIERAPRDGKNHFYLGELYLARQRPDAARVSFEKAVALHPLLETAWFHLGDIHLERRDLTAARESFTVATALAPEAVAMRGKLALVYQLEGDFAAAERELRRVVEKDPENMEFSLRLGLLYTEQAMKASRPEARKTAASEAERWLMKVLETQPENAVASRALQQLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7M0</accession>
    <name>Q1D7M0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92637">
        <property type="protein sequence ID" value="ABF92637"/>
        <property type="gene ID" value="MXAN_3150"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3150"/>
    <dbReference type="HOGENOM" id="CLU_2118426_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="114" mass="12912" checksum="09A9D1C93F7ED4A2" modified="2006-07-11" version="1">MSTRCWPRGMTLMVQIQENWADVRGQVLSWRQQSDVLHHGLLELTVTHVQAVEGFANLSRGIEGSTIRVYVPAEPGQARELAAGDLVSCRIRKTQHARYFSRPGRLEVLRLTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7X1</accession>
    <name>Q1D7X1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_3043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553099.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3043"/>
    <dbReference type="EnsemblBacteria" id="ABF87256">
        <property type="protein sequence ID" value="ABF87256"/>
        <property type="gene ID" value="MXAN_3043"/>
    </dbReference>
    <dbReference type="GeneID" id="41360405"/>
    <dbReference type="KEGG" id="mxa:MXAN_3043"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_2_7"/>
    <dbReference type="OMA" id="VHIRMEN"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="225"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="32978" checksum="35EA1265003BA343" modified="2006-07-11" version="1">MEATTLTDRNLAQQERNRKVRRVLLGILVANWVVASAKLIFGMLSQSAAVTADGLHSFIDGGSNVLGLVAMGVASRPADEDHPYGHGKFEALASLGIGAMIGVGMLELGRMALDSVLNDKHPQVTGTMAAVMAFTLVVNMVVTRVERYYGRKYKSSLLLADASHTMSDVYVTLAVLSSLLLVWLGYPRADGLIALAVMVFVAWVAYGIVRQAVGILSDTARLDPDEVKRHTLAVPGVRSCRDVRSRGMEESVYVDLKIEVDPQLTTAQAHEVADRVERTLQGAYPQVVDVVVHVEPDRAALDMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Z2</accession>
    <name>Q1D7Z2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3022"/>
    <dbReference type="EnsemblBacteria" id="ABF91753">
        <property type="protein sequence ID" value="ABF91753"/>
        <property type="gene ID" value="MXAN_3022"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3022"/>
    <dbReference type="HOGENOM" id="CLU_1694468_0_0_7"/>
    <dbReference type="OMA" id="FRTYFLY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="18640" checksum="4A0F8077F88ED0C4" modified="2006-07-11" version="1">MLEPCPPVPAGRSRMRILTVLAVLTFAVPAAAKPWQGIEPGVSKRDEIIKKFGEPSRTVKQDGKEIIAYLSKEAIKGTTQAQFKVDPDTQMVERIDVFPGPIIDKETVENSYGPSCPSGAAPATPCYLRKLTDDFRTYFLYPRLGLAIFFNEDGKTVQSLTFTTQKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D881</accession>
    <name>Q1D881_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552991.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2931"/>
    <dbReference type="EnsemblBacteria" id="ABF86420">
        <property type="protein sequence ID" value="ABF86420"/>
        <property type="gene ID" value="MXAN_2931"/>
    </dbReference>
    <dbReference type="GeneID" id="41360298"/>
    <dbReference type="KEGG" id="mxa:MXAN_2931"/>
    <dbReference type="eggNOG" id="ENOG5032JR4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686648_0_0_7"/>
    <dbReference type="OMA" id="WEAYCAG"/>
    <dbReference type="OrthoDB" id="824618at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188316" evidence="1">
        <location>
            <begin position="21"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="41349" checksum="C06392C4C01B35F7" modified="2006-07-11" version="1">MNRRWTLAVLLAASMGSCTRGDLVATVQSPDAGHVGSSVDAGGPDGGEPPADWEAYCAGRGPPIVVGDADTDSQVCSGRLAERTFRHALCTCEGLALGASFETDAFHGTSERYQPGGAGGDVGVNGALSANDAVAVGGSLRIGGAGGAQLGQTFRVGEALHCGGPLTGNPVSATVVGDARVRGDVALPAFSVGGVLMVPAGHVLGPVDAAEVRREPVDPVIPCACDAASQVDVSGLIARHVLDNDNVAIGLDATAMEDIEGERALELPCGRFHLTRITGTGRATLTIRARTALFVEDVVDLGEGLSVDVQAPGELDLFLGGSVAVAGPLTLGSTATPSRVRVYAAGSNVLALSAGSFLAGNLYAPRAVLSLSGGAEVFGSVFVRQVEASGPLRLHYDADIRDAGAECMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8W8</accession>
    <name>Q1D8W8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2688"/>
    <dbReference type="CAZy" id="PL12">
        <property type="family name" value="Polysaccharide Lyase Family 12"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91274">
        <property type="protein sequence ID" value="ABF91274"/>
        <property type="gene ID" value="MXAN_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2688"/>
    <dbReference type="eggNOG" id="COG5360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022012_0_0_7"/>
    <dbReference type="OMA" id="WCAEHDG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="612" mass="66020" checksum="B1AABD4A6FC3802C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D924</accession>
    <name>Q1D924_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cysS</name>
        <name evidence="13" type="ORF">MXAN_2630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2630"/>
    <dbReference type="EnsemblBacteria" id="ABF93120">
        <property type="protein sequence ID" value="ABF93120"/>
        <property type="gene ID" value="MXAN_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2630"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_7"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="368"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF93120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="504" mass="56578" checksum="F4A29E964AF7C24B" modified="2006-07-11" version="1">MRDTPTPMDPRGLPHVTPPAIRLFNTMTMQKELLQPAIPGEVGVYVCGPTVYSYIHIGNARTFTSFDVVVRYLRHRGLKVRYVRNFTDVDDKIIKAAAETGEAPVELAARYVEIFREDTRALHLLEPDFSPRVSDHLPEIIAIIQKLVDKGHAYASQGDVYFSVSSDEDYAKLSKRNLDELCVGERVQPGEQKREPLDFALWKAAKPGEPAWESPWGPGRPGWHIECSAMSAKYLGETFDIHGGALDLIFPHHENEIAQSESANGVTFARYWMHCGFLDLEGAKMSKSLGNVVRLRDALTKVDPEALRFFFLATHYRHPLSFSDKALADAETRMEYFYETLRKVDERISGKDFGKGPLHGDPQRFFTEFESAMDDDFNTAGGLGSLSGLFGMMNELTDKPPVKDKALVGRTLHALREDVRRVSSVLGLFEDAPDAWLLRRRERAVRERGIDVAEVERLLGERTAARAAKDFAAADRVRSELKEKGVEIMDTPAGTTWKVAPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D948</accession>
    <name>Q1D948_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574080">
            <id>Q1D8M1</id>
            <label>MXAN_2785</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574283">
            <id>Q1D1W0</id>
            <label>MXAN_5211</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574240">
            <id>Q1CWQ1</id>
            <label>MXAN_7059</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574045">
            <id>Q1CWA4</id>
            <label>MXAN_7206</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574250">
            <id>Q1D8M8</id>
            <label>phoP2</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574436">
            <id>Q1CYI5</id>
            <label>phoR3</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
        </interactant>
        <interactant intactId="EBI-1574809">
            <id>Q1DDJ8</id>
            <label>sdeK</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552676.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D948"/>
    <dbReference type="IntAct" id="Q1D948">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2606"/>
    <dbReference type="EnsemblBacteria" id="ABF90438">
        <property type="protein sequence ID" value="ABF90438"/>
        <property type="gene ID" value="MXAN_2606"/>
    </dbReference>
    <dbReference type="GeneID" id="41359983"/>
    <dbReference type="KEGG" id="mxa:MXAN_2606"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310328_0_0_7"/>
    <dbReference type="OMA" id="DTMAIQK"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50110"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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    </evidence>
    <sequence length="970" mass="106705" checksum="D3AFD8D044A58B91" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA10</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89187.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="286" mass="31763" checksum="F042706CCF58091B" modified="2006-07-11" version="1">MVERACGQALAPIPVRAAPRHASLPSASPAVRDYRLCRQHAHTERRRSMFQSRRRRVLAGVMMGAALSVASVGCSSTRSAKVDESWLARVPESQLGDVREAQTQRRTAQDAVTRSDVALNDARRELEVARRNEDAAKSRRKAHDEALKAANATGQSSNITQAQAELKSADSSMSAAQAQVRYREHTIKTMEALKDLRESELAEADAKLSQAEYEALKTNQDVRAQNLSEADFASATADAQRKVEESQRKLQSQQQQERQARATWERMRNQVQGYGGSGTEHKQRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF91240">
        <property type="protein sequence ID" value="ABF91240"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MMCoA_mutase_a_cat"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52242"/>
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    </dbReference>
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        <property type="entry name" value="acid_CoA_mut_C"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="597"/>
            <end position="729"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="730" mass="79616" checksum="C53F8BA738B02A14" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAJ0</accession>
    <name>Q1DAJ0_MYXXD</name>
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        <submittedName>
            <fullName evidence="5">Conserved domain protein</fullName>
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    </protein>
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        <name evidence="5" type="ORF">MXAN_2106</name>
    </gene>
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            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2106"/>
    <dbReference type="EnsemblBacteria" id="ABF93057">
        <property type="protein sequence ID" value="ABF93057"/>
        <property type="gene ID" value="MXAN_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2106"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2274337_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF93057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="102" mass="10786" checksum="CBDA77586552DB7C" modified="2006-07-11" version="1">MSPSRTAHLVVELGFGDTSKGTLTDWLVRRHGAGLVVRFNGGAQAGHNVITDDGPHHTFSQFGAGTFVPGVRTHLALTTLLHPLAMRVEVSSPLCQGSCRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAJ9</accession>
    <name>Q1DAJ9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552179.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2096"/>
    <dbReference type="EnsemblBacteria" id="ABF87496">
        <property type="protein sequence ID" value="ABF87496"/>
        <property type="gene ID" value="MXAN_2096"/>
    </dbReference>
    <dbReference type="GeneID" id="41359502"/>
    <dbReference type="KEGG" id="mxa:MXAN_2096"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045796_0_0_7"/>
    <dbReference type="OMA" id="DRANECW"/>
    <dbReference type="OrthoDB" id="994146at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="37382" checksum="1C10F2350F02DEB2" modified="2006-07-11" version="1">MLQVRNETPFSPSMFMFPDVRGMDTLYVVVKATFTFRKGRLFIAENQQPVVMADTFRGEPGQSSIRAASEAHLLKPGTDVLLEGEAHAPRGKPVASCPVLVRVGPVKQVIQVFGDRKWRGGVLSPGISSPEPFVKMPLVWERAYGGVHEVTKERVLGKASNPVGQGFCGKRGGSEMVGRALPNLEDPRQLIRSISDDPVPMGVGPVAPSWEPRKSYAGTYDEAWRTRRAPYLPLDFQAEFFQVAPAGMCARERLKGGEPVELINVSLEGVQRYTLPRCGLSVTVKIAGLFERPPLHLETVGLEPGSGRVCMTWRGAVGCDKRALKVEEARFQLLSLEGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAP8</accession>
    <name>Q1DAP8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trmL</name>
        <name evidence="6" type="ORF">MXAN_2046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552130.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2046"/>
    <dbReference type="EnsemblBacteria" id="ABF87195">
        <property type="protein sequence ID" value="ABF87195"/>
        <property type="gene ID" value="MXAN_2046"/>
    </dbReference>
    <dbReference type="GeneID" id="41359455"/>
    <dbReference type="KEGG" id="mxa:MXAN_2046"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110125_1_0_7"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="OrthoDB" id="1578095at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="18342" checksum="A13A18FF20EC116D" modified="2006-07-11" version="1">MLEPLARPLHLVLVSPQIPPNTGNVARLCAVTGCRLILVEPLGFSIDDRQLKRAGLDYWDKVFLRLYPTYAAYAADYPDARRWLFSARAETSLYEARFEEGDHLVFGSEVSGLAPEVMEGGTGTAVTIPMLEDRRSLNLSTSVGIGTYEALRQVRFTGAGRQAPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB13</accession>
    <name>Q1DB13_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552016.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1916"/>
    <dbReference type="EnsemblBacteria" id="ABF87904">
        <property type="protein sequence ID" value="ABF87904"/>
        <property type="gene ID" value="MXAN_1916"/>
    </dbReference>
    <dbReference type="GeneID" id="41359330"/>
    <dbReference type="KEGG" id="mxa:MXAN_1916"/>
    <dbReference type="HOGENOM" id="CLU_653503_0_0_7"/>
    <dbReference type="OMA" id="RWRFLPK"/>
    <dbReference type="OrthoDB" id="440243at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188446" evidence="1">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="421" mass="44420" checksum="B04AE22313945DB2" modified="2006-07-11" version="1">MKQPATFWGGLGALALLALGGTASAQGIATPPTGGNGFKVGNGRLHPYFDLETRLDSGVGYFSPTSNSEPNSDPVSANLASDVALRFRPGFRLEIPSSTLAFNLGANLDYVLYTGLVTKNSSAASRMEGAADLNARFNPDAPLTLEVSNQFARSDRTRTAAVGVGVLSLFNEARAKAPWRPGGGALELTPSVAYAVEFFQPLSSVSPVGCTESVCDPAAVERFDYGNLRVGAEGRWRFLPKTAVVLDTHLDVRSYFNDSTPGASLLRVIGGVAGLVSPKVAVTAKAGWGQNFGSTGGGTFLGQLEGTYLYSPTLSFKAGYLRTLEPVAAYGFFTDNRGYGEVRALFGGKLTVSGGLAVDFLRFDGGRNDTVVGVNIGPEYQFYPWLTGAAGYMLGRRSSSVDGGGLNYSRHEGYARLSVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB67</accession>
    <name>Q1DB67_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551962.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1860"/>
    <dbReference type="EnsemblBacteria" id="ABF92191">
        <property type="protein sequence ID" value="ABF92191"/>
        <property type="gene ID" value="MXAN_1860"/>
    </dbReference>
    <dbReference type="GeneID" id="41359276"/>
    <dbReference type="KEGG" id="mxa:MXAN_1860"/>
    <dbReference type="eggNOG" id="ENOG5032P4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313975_0_0_7"/>
    <dbReference type="OMA" id="DKVTGWH"/>
    <dbReference type="OrthoDB" id="1169247at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23266" checksum="A3A67DCDB065E7F2" modified="2006-07-11" version="1">MYATVADMRAEGVTPAMAGDTRLAVLLDEATRTIDKVTGWYFEPRSATLHLDGRGTPSLWLPVPPIRLYRLALYGADVSFSKEHLVVVGAPVGPGFDGPRLTFRHGRVFPRGEGNVTVGARWGYTEADGTPEGRTPAAVRRACMLLVLRSLSPLADEASLEERTRWRVVEERTREQSYRLDTVRPAVRPLTGEPEVDTLLAPYVKPSLPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBA8</accession>
    <name>Q1DBA8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551924.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1819"/>
    <dbReference type="EnsemblBacteria" id="ABF87105">
        <property type="protein sequence ID" value="ABF87105"/>
        <property type="gene ID" value="MXAN_1819"/>
    </dbReference>
    <dbReference type="GeneID" id="41359236"/>
    <dbReference type="KEGG" id="mxa:MXAN_1819"/>
    <dbReference type="eggNOG" id="COG2105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083466_5_2_7"/>
    <dbReference type="OMA" id="KEKYAMY"/>
    <dbReference type="OrthoDB" id="1984556at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="PTHR12510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGACT" evidence="3">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="14800" checksum="8ECED4DF2825A2F0" modified="2006-07-11" version="1">MKHASTSTRVFVYGTLLGGEPNHRLLRGARLIGPARTQPRFTLYDYGPFPALASRGKHAVEGEVYEVDALMLAALDRLESHPRFYRRTPITLDDVGRVEAYLFPKERLAGRPIIESGCWRRHLQERKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE7</accession>
    <name>Q1DBE7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551885.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1776"/>
    <dbReference type="EnsemblBacteria" id="ABF88725">
        <property type="protein sequence ID" value="ABF88725"/>
        <property type="gene ID" value="MXAN_1776"/>
    </dbReference>
    <dbReference type="GeneID" id="41359201"/>
    <dbReference type="KEGG" id="mxa:MXAN_1776"/>
    <dbReference type="HOGENOM" id="CLU_1150349_0_0_7"/>
    <dbReference type="OMA" id="YYGHHPV"/>
    <dbReference type="OrthoDB" id="1536569at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="29358" checksum="D1A8EF7F56FE4EB0" modified="2006-07-11" version="1">MSRMNLAGLVAILMLASSGVVEAKQWRYAGMHPRTGLPADGLCHIEMMHVHTAAPMHADTLYRTRDNVYVFIGDPTPFGYEGPQHAYYGHHPVVLNVLVRIDVDVDVVEYCYHDGPHYHAYPPPPRQEFVDKEDVHYYAGEYPQEYRRESPKLVRVNTVYRSWSAPRPVVTLAPPPEYHGPVIQVGLNIPLPSVEVRVGTPRPPPPPPPEWERDVIRHEHVHVHHDHCEHHVHKKHKHKHKHKKHKHKKFKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBL3</accession>
    <name>Q1DBL3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551819.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1709"/>
    <dbReference type="EnsemblBacteria" id="ABF86549">
        <property type="protein sequence ID" value="ABF86549"/>
        <property type="gene ID" value="MXAN_1709"/>
    </dbReference>
    <dbReference type="GeneID" id="41359147"/>
    <dbReference type="KEGG" id="mxa:MXAN_1709"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080971_0_0_7"/>
    <dbReference type="OMA" id="FHGFTMD"/>
    <dbReference type="OrthoDB" id="1496081at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011745">
        <property type="entry name" value="RNA_pol_sigma70_MYXXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03001">
        <property type="entry name" value="Sig-70_gmx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="33060" checksum="B28C4C5DFD86743E" modified="2006-07-11" version="1">MSDEQRTGSLAALLRAYVSPKLRAELEAEEGFEALLDKHVEAARTQWPTLSLPAETFVRHLARHLPEGKAAEVMRILQGADLYLACACTTGDPAALKAFEQHILRHVPPRLGKVSPPLVEEVLQMLRERLLVGSSNTPPRIASYGGRGPLRTWVSIVAARIASELMGQDERHQLVAEPPEELARMLAPSDPEYALLREDARQLLVESLRKAVAVLSEQERTLLRLHHFHGFTMDRLTLMYGGSRSGVARKVADAREQLLERVRMELAPRMKQDQLALESLLGLVSSRLDISLLGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBW7</accession>
    <name>Q1DBW7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551715.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1604"/>
    <dbReference type="EnsemblBacteria" id="ABF86978">
        <property type="protein sequence ID" value="ABF86978"/>
        <property type="gene ID" value="MXAN_1604"/>
    </dbReference>
    <dbReference type="GeneID" id="41359049"/>
    <dbReference type="KEGG" id="mxa:MXAN_1604"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387167_0_0_7"/>
    <dbReference type="OMA" id="ENRVARQ"/>
    <dbReference type="OrthoDB" id="371311at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="585"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="695" mass="73880" checksum="38508176D244F44A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ1</accession>
    <name>Q1DBZ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551691.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1580"/>
    <dbReference type="EnsemblBacteria" id="ABF90597">
        <property type="protein sequence ID" value="ABF90597"/>
        <property type="gene ID" value="MXAN_1580"/>
    </dbReference>
    <dbReference type="GeneID" id="41359025"/>
    <dbReference type="KEGG" id="mxa:MXAN_1580"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492444_0_0_7"/>
    <dbReference type="OMA" id="ASGMQHM"/>
    <dbReference type="OrthoDB" id="299620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="429"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="61048" checksum="62BCAFC96FF431EC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC36</accession>
    <name>Q1DC36_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551646.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1535"/>
    <dbReference type="EnsemblBacteria" id="ABF87882">
        <property type="protein sequence ID" value="ABF87882"/>
        <property type="gene ID" value="MXAN_1535"/>
    </dbReference>
    <dbReference type="GeneID" id="41358980"/>
    <dbReference type="KEGG" id="mxa:MXAN_1535"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_7"/>
    <dbReference type="OMA" id="IGESARW"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="35110" checksum="232EBCC6A1F6AC76" modified="2006-07-11" version="1">MNTQVALWVGFNVFVLAMLALDLGLFHRKDHAVTPKEAGLWTLVWITLSLIFCAGIWHYQGPTVGLQWLTAYVVEYALSVDNLFVFLMVFSYFRVAPEHQHRVLFWGILGAFVMRAGLIIAGTALVKQFHWLIYLFGAFLVFTAVKMLVSKDEEMDPEQQGIVKFARRVLPVARLGEGSRFMVQEDGRSKFTPLFIVLLVVEATDLLFALDSIPAVLGISQDAFIIYTSNVCAILGLRSLFFVVASLMEKFHFLKVGLSAILGFVGVKMLITFFDIHVPIGISLGVIAGVLVAAIVASLVWPKQPEPGQDRESAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC84</accession>
    <name>Q1DC84_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551598.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1482"/>
    <dbReference type="CAZy" id="CBM8">
        <property type="family name" value="Carbohydrate-Binding Module Family 8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87771">
        <property type="protein sequence ID" value="ABF87771"/>
        <property type="gene ID" value="MXAN_1482"/>
    </dbReference>
    <dbReference type="GeneID" id="41358928"/>
    <dbReference type="KEGG" id="mxa:MXAN_1482"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610878_0_0_7"/>
    <dbReference type="OMA" id="ILVFHEF"/>
    <dbReference type="OrthoDB" id="463812at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="76"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="48557" checksum="CFFCDE7D9F0EAE22" modified="2006-07-11" version="1">MSAWRICQLQVACPRGLAGCPASVPSGIEFIMPHEADSPRWGKSMSSPHGVFRRFVSLLLLSLAPPAFAAAPFTEGMVTITLDDGWATQFSLARPELNARNIPATYGLVTLAIHEGWGGYMSLAQAQTLVTDGNDIASHTLTHPDLTSLSPTQLAAELQDSRAWLESALGLPAVPNLVVPYGLQNGPVLDAIRQHYASSRTVNAGRNFRDTLVYELRANDVARTVPVSTVQGWVDQTIAEKSWLILVFHEFVNGTPTRDTQYETSHFADILDYVKTRGVRTVTLAEGLALTEGRTEPDLTAGLFVYTDALQNGFANWSWADHSLDETGVVHAGSAAIRFEPDTWNGLLFHHHGLDLAQYQSIRVWVHGGTAGGQAVRLVLHDGTQMLGTTRLDTALGAPIAPGVWQQVTIPLSSIGATTGTLRDIYFQDDSGTDQPALYLDDVVLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC0</accession>
    <name>Q1DCC0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551562.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1446"/>
    <dbReference type="EnsemblBacteria" id="ABF87672">
        <property type="protein sequence ID" value="ABF87672"/>
        <property type="gene ID" value="MXAN_1446"/>
    </dbReference>
    <dbReference type="GeneID" id="41358892"/>
    <dbReference type="KEGG" id="mxa:MXAN_1446"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_7"/>
    <dbReference type="OMA" id="PMHAINV"/>
    <dbReference type="OrthoDB" id="1863280at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18013" checksum="31D4989799AB9D27" modified="2006-07-11" version="1">MAGRKQRQWVKPQAQPNSEINVTPLVDVVLVLLIIFMVVTPLLEKDIVVRVPDTEVDQEPTPPDPNDQQLVVQLDKDGGYSINTEKIAPADYVTRLKRMLAAKKADDKVVFFMADDATNYGRLITALDGAKTAGAKVLGMATELPQNAIIQGTSVDTPTPPPAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD45</accession>
    <name>Q1DD45_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86409">
        <property type="protein sequence ID" value="ABF86409"/>
        <property type="gene ID" value="MXAN_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1168"/>
    <dbReference type="eggNOG" id="COG4103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2771568_0_0_7"/>
    <dbReference type="OMA" id="TRCLQNN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="69" mass="7386" checksum="D89FF9D23AB15E84" modified="2006-07-11" version="1">MSVPLQELAALTRCLQNNEPLPPPNMGILRANPAAVIQEAKALIASDGSVHAAEIEMLRQIRELLGVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDB5</accession>
    <name>Q1DDB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551218.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1098"/>
    <dbReference type="EnsemblBacteria" id="ABF88469">
        <property type="protein sequence ID" value="ABF88469"/>
        <property type="gene ID" value="MXAN_1098"/>
    </dbReference>
    <dbReference type="GeneID" id="41358550"/>
    <dbReference type="KEGG" id="mxa:MXAN_1098"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_7"/>
    <dbReference type="OMA" id="HCRFVNM"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="282" mass="30366" checksum="01079DB2B50BFBA3" modified="2006-07-11" version="1">MEQRPFGSTRVSVPVLGQGTWQMEEDDRAGAIRALRAGLDLGMTHVDTAELYGYGKVEESIVSEAIAGRRGDVFLVSKVMPSNASYAGTLAACERSLKRLRTDHLDCYLLHWPGSHPLEETVRAFEKLVVDGKIRAWGVSNFGVEDLEEALALAGPGRIACNQVLYHLEERAIEHAVLPWCEAHGVAVVGYSPFGNGRFPRPDSRGGKVLGGIARAHGVTPYQVALRFLVRGPSLFAIPKASREAHARDNAAAASLTLTADELAHLDAAFPLGPEPASLPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDC8</accession>
    <name>Q1DDC8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="13">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">MXAN_1085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551205.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1085"/>
    <dbReference type="EnsemblBacteria" id="ABF89852">
        <property type="protein sequence ID" value="ABF89852"/>
        <property type="gene ID" value="MXAN_1085"/>
    </dbReference>
    <dbReference type="GeneID" id="41358536"/>
    <dbReference type="KEGG" id="mxa:MXAN_1085"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_7"/>
    <dbReference type="OMA" id="CDDVIMD"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 13" id="KW-0288">FMN</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0874">Quinone</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="14">
        <location>
            <begin position="334"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="48501" checksum="E5763310B52E11CE" modified="2006-07-11" version="1">MASTAKTIEPIISAAWGKPQSWTLDSYRKRGGYEALKKALQMEPAAIIDEVKKSNLRGRGGAGFPTGLKWSFVPKDSPKPKYLAVNGDESEPGTFKDRYILEDDPHMMLEGIAIASYALGVHTCYVYLRGEFKFPAERTQAAIDEAYKAGIFGKKVLGKDYELNCYLVRGAGAYICGEETALLESLEGKKGWPRLKPPFPAVVGLFGCPTVVNNVETLASVPAIFQQGAEAYAKLGTDKSGGTRLVCLSGTVNRPGVYEVSMFTTLSELIFDDKYGRGMPAGRKVKAVIPGGSSAPVLGADELDVAMEFEALKVKQTMAGSGGVIVMDDTTCMVRSLWRVARFYAEESCGQCTPCREGTPWQTRLLRKIEEGRGEPGDIDMLSNVASSIAPYPPIGLGNTICALGDAAALPTHSFLMRFRDEFEAHIREHRCPFGDKPWGSFGDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS4</accession>
    <name>Q1DDS4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551059.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0938"/>
    <dbReference type="EnsemblBacteria" id="ABF87026">
        <property type="protein sequence ID" value="ABF87026"/>
        <property type="gene ID" value="MXAN_0938"/>
    </dbReference>
    <dbReference type="GeneID" id="41358397"/>
    <dbReference type="KEGG" id="mxa:MXAN_0938"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="RWVWLDG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="180"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="265"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="53163" checksum="177F3C5836BD1B52" modified="2006-07-11" version="1">MRLARKFTLALVLLAIAVMAGLQYVQVRRELERSALDMQHDHRLLGHTLAGSIGKAWQLAGEREALTLLHQANRFQEQVHLRWVWLDGGPGTPALTGFPPRLLSTLLQGKDGSMVDPAVDPGLLHSYTPVLIGNRLGAIEITESLGEQQKYVNTVVMGTFAATAAMAIGFIVAAMAMGRRLVGEPVDQLVSLAHRIGEGDLTARVPLPQRRGDELTTLAGAMNRMGEQLEETRSRLATETAARLSAVDHLRHADRLTTVGKLASGVAHELGTPLNVVMGRAKMISSGEAEGEEVGECAQIISQQAQHMTAIIRQLLDFARRRKPHRAPEDVQGLVERTLSLLRSMAARNSVTLETDIPAGLTVEVDAGQVQQVLTNLVMNGVQAMKQPGTVRVRAAHTRSTPPPDVGGPEADFVRLDVEDEGQGIPEDVLAHLFEPFFTTKDVGEGTGLGLSVSYGLMLEHDGWIAVRSEPGRGSCFSIYLPRGEDTCQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX9</accession>
    <name>Q1DDX9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0883"/>
    <dbReference type="EnsemblBacteria" id="ABF93150">
        <property type="protein sequence ID" value="ABF93150"/>
        <property type="gene ID" value="MXAN_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0883"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104157_0_0_7"/>
    <dbReference type="OMA" id="WLVWEAG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="25287" checksum="B2CE1E606CEE5607" modified="2006-07-11" version="1">MPCPGDRRRSRVYYRGQPGREWGIPPASGHSLTSHGPPRAPSRAATGEEGYSTRMARALLLSLLVRQHMALKEKFRAKYPHPWLVWEAGAWNVPEVVEGNVAATRLPLTDLRDCLPAGDALCFELVGQTDGSPLRLGRASNNALVVNDATVSREQLHLSPTLEGRWTVTRVAASRTVTLGGTALEPEQPTVLQPGVQLHVGDVRLTFHAAEDFDERIGRIAAQVLAQTAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDY4</accession>
    <name>Q1DDY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550999.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0878"/>
    <dbReference type="EnsemblBacteria" id="ABF90878">
        <property type="protein sequence ID" value="ABF90878"/>
        <property type="gene ID" value="MXAN_0878"/>
    </dbReference>
    <dbReference type="GeneID" id="41358337"/>
    <dbReference type="KEGG" id="mxa:MXAN_0878"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433345_0_0_7"/>
    <dbReference type="OMA" id="WHFVARV"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="300"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="352"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="67911" checksum="74FDA632F2A53905" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE76</accession>
    <name>Q1DE76_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550907.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0781"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92382">
        <property type="protein sequence ID" value="ABF92382"/>
        <property type="gene ID" value="MXAN_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="41358249"/>
    <dbReference type="KEGG" id="mxa:MXAN_0781"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045353_0_0_7"/>
    <dbReference type="OMA" id="FDPWKDL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="225"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="436" mass="48488" checksum="793BACB43E5493B1" modified="2006-07-11" version="1">MLDVVDIGKRSLATYRGIAPDEILDELHWLSEDLRGARCMHLSSTPYGGGVSEILRSLVPLYNDLGIVTDWKLIHGDDTFFQVTKRIHNGLQGAPGELTEREKATYLANAQLNAHRLVTNSENYDFVFVHDPQPAVLAALSPHLDARWIWRCHIDTSHPNPTFWDFLSPYLHAYDAAIFTMREFIPPQLPISDVRIYPPAIDPLSPKNHPLPEALARDVLEWIGIRTHRPLVTQVSRFDRWKDPLGVVRAYQRVRPHVPDLQLALAGSLAMDDPEGWDVYEELRAATAGDSLIHILTNLVGVGNIEVNALQAVSDVVVQKSLREGFGLVVAETLWKSTPVVGGRVGGIPMQLPEGTGGALVDTVEECAEAMLHLLRRPDEAHLLGARGHEHVRQHLLMPRLLVDHLRLLKHLAAVRPLPPRGIVPVSFNPASLQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEH5</accession>
    <name>Q1DEH5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DGPF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0680"/>
    <dbReference type="EnsemblBacteria" id="ABF89037">
        <property type="protein sequence ID" value="ABF89037"/>
        <property type="gene ID" value="MXAN_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0680"/>
    <dbReference type="eggNOG" id="COG3795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130902_2_1_7"/>
    <dbReference type="OMA" id="KYLCQVW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLH55582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13906" checksum="6D22341AF6A44D18" modified="2006-07-11" version="1">MRHGPMKYLLMIYENEKAAEAMSEADVQRVMGEYGTFEVAIQQSGHFISGEELEPTTAATTVRIRDGKRLTTDGPFAETREQLGGFFLVEARDLDEAIGIASRIPSARSGSIEVRPVREFARPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL8</accession>
    <name>Q1DEL8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase, M48 family</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550768.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0637"/>
    <dbReference type="EnsemblBacteria" id="ABF90625">
        <property type="protein sequence ID" value="ABF90625"/>
        <property type="gene ID" value="MXAN_0637"/>
    </dbReference>
    <dbReference type="GeneID" id="41358115"/>
    <dbReference type="KEGG" id="mxa:MXAN_0637"/>
    <dbReference type="eggNOG" id="COG4784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924112_0_0_7"/>
    <dbReference type="OMA" id="LEWTFGV"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188451" evidence="8">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="90"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="328" mass="34515" checksum="4F8F02E56A7FC5B1" modified="2006-07-11" version="1">MMRTGWKVLALVGLGALTASCKGFNASSLTRGENILGKLSAASAEAKTCKKLRAAPSVQEEYALGGALAINFVRRGGGLLLDGPNDALHRYVNVVGKNLAAQSARPTLEWTFGVLQDTSQFNAMSAPGGYVFVTRKLLQGLENEGQLAGVLAHEIAHVTLKHAIHQYGDAKVKTCELVTYGEAVLSPTAVKVLSAGRNGDGTLDLDQDPGLLGHLSEKTIDLIDKGNAKEQELEADRIAVELMLSAGYTPDDYLALLAKTKDGGSTFANHPGKDERRRNILAHVQALKQPAGAFSGLATEGLRSPPLSPAFAAVRGGNNPRGVAKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF52</accession>
    <name>Q1DF52_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550584.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0451"/>
    <dbReference type="EnsemblBacteria" id="ABF87736">
        <property type="protein sequence ID" value="ABF87736"/>
        <property type="gene ID" value="MXAN_0451"/>
    </dbReference>
    <dbReference type="GeneID" id="41357944"/>
    <dbReference type="KEGG" id="mxa:MXAN_0451"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064587_0_0_7"/>
    <dbReference type="OMA" id="PGGTHWP"/>
    <dbReference type="OrthoDB" id="1742143at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="6">
        <location>
            <begin position="147"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="34251" checksum="BDFF06D9488E01D5" modified="2006-07-11" version="1">MTSRSPNKVTALTWLSTVLGLSHLTLVYATGRLRWDHVAADALILGVAWSGPRLQRFLRGGLALWLTGMLLDSQGLWLFLRGPIHTGDLWELERQWFPAPGGTHWPEWWATRFTPAMDLLCGFAYAAYLYEVFILAIFFFVKKDSLFERLCWGFLAANAIGVVIYVLYPAAPPWYVLQYGPGPADLAAPPNPAGTARFDELLGISYFASFYSRSTNVFGAMPSLHAAYPFLVTLFVWSRGWAWRISTGLFALLVAFSAVYLTHHYILDVLAGLGVAAVAFLAVESVYARWTATTPWAVSLTTRGDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF81</accession>
    <name>Q1DF81_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550555.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0421"/>
    <dbReference type="EnsemblBacteria" id="ABF88416">
        <property type="protein sequence ID" value="ABF88416"/>
        <property type="gene ID" value="MXAN_0421"/>
    </dbReference>
    <dbReference type="GeneID" id="41357915"/>
    <dbReference type="KEGG" id="mxa:MXAN_0421"/>
    <dbReference type="eggNOG" id="COG1915">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056125_0_0_7"/>
    <dbReference type="OMA" id="GHKHHIY"/>
    <dbReference type="OrthoDB" id="718059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="39719" checksum="C28A252E10987DE7" modified="2006-07-11" version="1">MSSIPHPDFTAARFSSCPDARFQPAPADGVLPEGFFTTTNLPTYVRVGGAWRMPREPRMDGALVLDAQGELWIREGRRVRAGEHVVVGFAEDGSEGVFVNSAYLADEGEGEFKFMTSAVSREKPIDYAHMARVLVDERERGGYPIWVTGPALVHSRARADMTWFVANGFVGALLAGNAVAVHDIEASIFGTTLGMSGSGEATSGGHGLHMRAINKVRAAGSIAKAVEAGVITSGIMHACVVHKVPFVLTGSIRDDGPLPDVVTDNLEAQVAMREHAVKSTMAVMIATALHAIATGNMLPAFVTEKDGSLRELPTICVDSSEFVVSKLKDRGTHQAFGVVTNAQDFMHVLRLYVERDLAARGLPVPGDALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL0</accession>
    <name>Q1DFL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550427.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0283"/>
    <dbReference type="EnsemblBacteria" id="ABF91743">
        <property type="protein sequence ID" value="ABF91743"/>
        <property type="gene ID" value="MXAN_0283"/>
    </dbReference>
    <dbReference type="GeneID" id="41357783"/>
    <dbReference type="KEGG" id="mxa:MXAN_0283"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917732_0_0_7"/>
    <dbReference type="OMA" id="GVQFVEN"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="32530" checksum="919C14B98D42CF98" modified="2006-07-11" version="1">MMTMTGKRRFLGAVLAVGMLGGCEPLDDGGGGGIGGVLFTRGFAFVREDDRNVYVVDDGGDANSPQRLTNVGGAYWPSVSRDGRSVVFVQRSGGTTTLLTVPTSGGTPSTLFRANDSTCARGCSNFRTPTFSPDGRSVVFVFSPGNSSQTALARINTDGSGFQELTPNNVIAYGAPSFVPNGGAVLAGAGSGLNQLDQLAHVPLNGGTITYSSLSAGVQFVENRVAVSPNGSQVALDGRLSSGGTRIFVAQLSGSNVGALQRVTIGGAGEESWPSWTGASQLGFLISAGGSDTGIYRANLSTGSVSLAVPSATEPSYGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN1</accession>
    <name>Q1DFN1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550406.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0261"/>
    <dbReference type="EnsemblBacteria" id="ABF87764">
        <property type="protein sequence ID" value="ABF87764"/>
        <property type="gene ID" value="MXAN_0261"/>
    </dbReference>
    <dbReference type="GeneID" id="41357761"/>
    <dbReference type="KEGG" id="mxa:MXAN_0261"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022019_0_0_7"/>
    <dbReference type="OMA" id="RVSPYVA"/>
    <dbReference type="OrthoDB" id="1326125at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="2">
        <location>
            <begin position="127"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="28658" checksum="AD5A579EB1CB510A" modified="2006-07-11" version="1">MHLGATLRLLRTDAGLSLRDLARRIGVSSAYLSRVENGVDAPPTPERLSAIARELRVPSSLLMDVANRMSPSVAAYLEEVPGAGALFLDIAQRRLSGLQLARVRDFLEAEFPVAQGRRDAPVPPLAPLLAPERVVVQLSCAGWDDVLDVVAERLASSQPGADVARVVGGLKRHREESSCAVGGGVAVPHSFLPGAVPTAALVTLATPLAGDTPDGKPLRVVVAILDAERGNPQLVRLAHLARLAAHGLADRLLGLSQPAQVLSSLEELEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS8</accession>
    <name>Q1DFS8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550359.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0213"/>
    <dbReference type="EnsemblBacteria" id="ABF89470">
        <property type="protein sequence ID" value="ABF89470"/>
        <property type="gene ID" value="MXAN_0213"/>
    </dbReference>
    <dbReference type="GeneID" id="41357715"/>
    <dbReference type="KEGG" id="mxa:MXAN_0213"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_7"/>
    <dbReference type="OMA" id="QTVTHYV"/>
    <dbReference type="OrthoDB" id="1844486at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17610" checksum="E347741F48710082" modified="2006-07-11" version="1">MFLDELDHRIIDMLQRDGRATQLELSRAVKLSQPAVAERIRKLEERGVITGYSARVDAAKLGKDITAFIGVSIEHPKYFDEFLQKVLLLPDVLECHRVAGQDSYLLKVKTANTRSLDSLLVGTLRTIAGVTRTQTTIVLTSMKEDTHVRVPPDTPKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFW0</accession>
    <name>Q1DFW0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0180"/>
    <dbReference type="EnsemblBacteria" id="ABF88905">
        <property type="protein sequence ID" value="ABF88905"/>
        <property type="gene ID" value="MXAN_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0180"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_18_7"/>
    <dbReference type="OMA" id="RGWHVEV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="154"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="460" mass="50235" checksum="942EF533142C5B63" modified="2006-07-11" version="1">MAAEEVRPATPLLGIHDAGPCVRRREPGYAPAMPTSHLALPALDALAGPVLLVDDARKVTALTPALEALLGGTLRAGTPLAQVLGRADGTEPLDAVLKNGCEASVRLRVGGRSKPVRVRAVPLARGPRASGWALLVSPDAVEETNGRAELFHGLWTQAPELQRVFRIVEKVARTESSVLVRGESGTGKEHIAHALHALSARARGPFRAINCAALPPNLLESELFGHVRGAFTGAVRDSPGHFRLADKGSLFLDEVAEMPLDLQAKMLRVLETRTVIPVGGRQPVPVDVRIIAATHRPLRREVETGRFRADLMYRLRVVPLFLPTLRERRGDILPLALRFLEELHQRGARRVERFSPGARRLLEEHPWPGNVRELRNVMEYAYVIGEGPVVREADLPPEFSEQRQAAPAKLPPPDASLEPERIRAALAQAGGNRSEAARLLGVSRVTLWRRLRDLGATAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFW6</accession>
    <name>Q1DFW6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550321.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0174"/>
    <dbReference type="EnsemblBacteria" id="ABF91199">
        <property type="protein sequence ID" value="ABF91199"/>
        <property type="gene ID" value="MXAN_0174"/>
    </dbReference>
    <dbReference type="GeneID" id="41357677"/>
    <dbReference type="KEGG" id="mxa:MXAN_0174"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="TQQNAGI"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="258"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="530" mass="56135" checksum="AA10C8BDB933DA98" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG47</accession>
    <name>Q1DG47_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550240.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0093"/>
    <dbReference type="EnsemblBacteria" id="ABF90324">
        <property type="protein sequence ID" value="ABF90324"/>
        <property type="gene ID" value="MXAN_0093"/>
    </dbReference>
    <dbReference type="GeneID" id="41357600"/>
    <dbReference type="KEGG" id="mxa:MXAN_0093"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_7"/>
    <dbReference type="OMA" id="HITSPMC"/>
    <dbReference type="OrthoDB" id="1668114at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13737" checksum="22A3E1705E6307E7" modified="2006-07-11" version="1">MSEQALRERIQDIPDPCSCATGVPLGIGEMGLIESVKRTEGQVTVRLHITSPMCMMAAYFMREIEQRLLTVDGVTAVNVEFDHDLKWTPQDIEPEARQRLAARRITMLGGRLLPQDSAQRRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>P38586</accession>
    <accession>Q1CW47</accession>
    <name>DEVT_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>CRISPR-associated protein Cas8a1/Csx13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>CRISPR-associated protein Cas8a1/Csx13, Myxan subtype</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Fruiting body developmental protein T</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">devT</name>
        <name type="synonym">cas8a1</name>
        <name type="ordered locus">MXAN_7263</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="7450" last="7462">
            <title>devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus.</title>
            <authorList>
                <person name="Thoeny-Meyer L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="7693658"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 346-570</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="J. Bacteriol." volume="184" first="1540" last="1546">
            <title>The DevT protein stimulates synthesis of FruA, a signal transduction protein required for fruiting body morphogenesis in Myxococcus xanthus.</title>
            <authorList>
                <person name="Boysen A."/>
                <person name="Ellehauge E."/>
                <person name="Julien B."/>
                <person name="Sogaard-Andersen L."/>
            </authorList>
            <dbReference type="PubMed" id="11872704"/>
            <dbReference type="DOI" id="10.1128/JB.184.6.1540-1546.2002"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="J. Bacteriol." volume="189" first="3738" last="3750">
            <title>Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.</title>
            <authorList>
                <person name="Viswanathan P."/>
                <person name="Murphy K."/>
                <person name="Julien B."/>
                <person name="Garza A.G."/>
                <person name="Kroos L."/>
            </authorList>
            <dbReference type="PubMed" id="17369305"/>
            <dbReference type="DOI" id="10.1128/JB.00187-07"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>OPERON STRUCTURE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="function">
        <text>Functions in an unknown fashion to stimulate transcription of fruA independently of the intracellular A- and E-developmental signals.</text>
    </comment>
    <comment type="developmental stage">
        <text>Operon expression begins by 6 hours after starvation has initiated development and is under strong negative regulation by DevS.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Decreases sporulation 1000 to 10000-fold, aggregation is delayed. Delays for C-signal-dependent methylation of FrczCD and impairs fruA transcription. This mutant should not have polar effects on downstream genes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CRISPR-associated protein Cas8a1/Csx13 family. Myxan subtype subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L19029">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Unassigned_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A49941">
        <property type="entry name" value="A49941"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P38586"/>
    <dbReference type="STRING" id="246197.MXAN_7263"/>
    <dbReference type="EnsemblBacteria" id="ABF87502">
        <property type="protein sequence ID" value="ABF87502"/>
        <property type="gene ID" value="MXAN_7263"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7263"/>
    <dbReference type="eggNOG" id="ENOG502ZADP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_531807_0_0_7"/>
    <dbReference type="OMA" id="QHNKMRP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09713">
        <property type="entry name" value="Cas8c_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027811">
        <property type="entry name" value="CRISPR-assoc_Csx13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019989">
        <property type="entry name" value="CRISPR-assoc_Csx13_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03486">
        <property type="entry name" value="cas_csx13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03485">
        <property type="entry name" value="cas_csx13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0293">Fruiting body</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="chain" id="PRO_0000066192" description="CRISPR-associated protein Cas8a1/Csx13">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; L19029." evidence="5" ref="2">
        <original>EA</original>
        <variation>DR</variation>
        <location>
            <begin position="376"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="11872704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17369305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="570" mass="61287" checksum="B6DD202432EBA706" modified="2006-09-19" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV0</accession>
    <name>Q1CVV0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557278.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7366"/>
    <dbReference type="EnsemblBacteria" id="ABF92066">
        <property type="protein sequence ID" value="ABF92066"/>
        <property type="gene ID" value="MXAN_7366"/>
    </dbReference>
    <dbReference type="GeneID" id="41364526"/>
    <dbReference type="KEGG" id="mxa:MXAN_7366"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500400_0_0_7"/>
    <dbReference type="OMA" id="ANTCERF"/>
    <dbReference type="OrthoDB" id="699925at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="626" mass="65358" checksum="1CEDA1C961F35D1F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW2</accession>
    <name>Q1CVW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative beta-ketoacyl-acyl carrier protein synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557266.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7353"/>
    <dbReference type="EnsemblBacteria" id="ABF89527">
        <property type="protein sequence ID" value="ABF89527"/>
        <property type="gene ID" value="MXAN_7353"/>
    </dbReference>
    <dbReference type="GeneID" id="41364514"/>
    <dbReference type="KEGG" id="mxa:MXAN_7353"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_7"/>
    <dbReference type="OMA" id="NTDMCEV"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="132"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="288"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="370" mass="40152" checksum="6C67047611B94225" modified="2006-07-11" version="1">MTPNVCVVGAGAFVPSRVVSNERIARAIPGWPAERIEEKVGIRERRFLWDIDEATGRAIPPPENDGHIYPANNTDMCEVALQKALAQAGVDAKELDALFVVTCTPDAPHFNHDAMELHRRLELREDAFGLVVDDGCGGTPYVLDMVKKMMEGGRFRTVAVVASAFTSPLVNREVYTDELPPGPGRSKTLQGYLSMYVFGDGAGAVVLQSKPGESGAEGILASFSGNAYGDLVIRKGGGLLKLPYQPGRMRPADMAFVVDGFRVARSYPEYMQKCLDAVLGPRPELRSKVERYYFHQPNKRVMDAFVERAGLPREAVACNVDRYGNTSAAGMLILLAEDLEAGRVRLGSGDLVVVAAVGANVHYGAQLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB7</accession>
    <name>Q1CWB7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7193"/>
    <dbReference type="EnsemblBacteria" id="ABF88033">
        <property type="protein sequence ID" value="ABF88033"/>
        <property type="gene ID" value="MXAN_7193"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7193"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760375_0_0_7"/>
    <dbReference type="OMA" id="AFPFAQA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="37172" checksum="150EE76FEDB76386" modified="2006-07-11" version="1">MERVPLAMNDIAVLVNLRARRGSEGMGGLVQRFLPRARVALTRSLDEARAWISDTLRPNPPSLLLAGGGDGTITGLLNELRTAGVALPAIGVLPMGTGNAWARVTGAPRPAEALKQIAAVGERLPPLRPFALVRVEGKVAPFAGTGWDAEMIQDFKNQLAASGPLRSTQAGLRGYLGAMFTRTVPRHLFGEGNPSVSVYNLGDPALTVDARGSVQPVPHGDKGALLYRGPAGVAGAATTPEWGFGFKAFPFAQAVPHRLSVRVYGAGVIEATRNMFRLWRGEHPMPHMHDWFVQRLRMDFDREVPFQMGGDVIGMRRSLEFDLAEESVQLVDWRQLSRMVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWN9</accession>
    <name>Q1CWN9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556990.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89727">
        <property type="protein sequence ID" value="ABF89727"/>
        <property type="gene ID" value="MXAN_7071"/>
    </dbReference>
    <dbReference type="GeneID" id="41364246"/>
    <dbReference type="KEGG" id="mxa:MXAN_7071"/>
    <dbReference type="HOGENOM" id="CLU_1184014_0_0_7"/>
    <dbReference type="OMA" id="VWGRAPD"/>
    <dbReference type="OrthoDB" id="1557851at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26722" checksum="ED1DB9285677C49F" modified="2006-07-11" version="1">MSAPVFIYLTPPDGLVPLLTPARLAAFRDWLWRENTEHLNAEDLADIESDEELMALLGLVDHLLQQGAESLSKPPTRHADAMLDLLDELSDYFTREELGIPEGMELATDLKPTDKQVRASDVVIGENCPKRTFELWRHLVWGRAPDRTVAEGIGLRRNFPSMGYWTAAEVRHVRDDLRQHLSGAPDYMPMNNWARFMTSLRLKLTRTGRAAAPAPAIEAISRAVDRAAREGAGLLFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ8</accession>
    <name>Q1CWQ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88138">
        <property type="protein sequence ID" value="ABF88138"/>
        <property type="gene ID" value="MXAN_7052"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7052"/>
    <dbReference type="eggNOG" id="ENOG5032KAY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085690_0_0_7"/>
    <dbReference type="OMA" id="PLQSEKH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="31141" checksum="86DD1E0E45CA3EFD" modified="2006-07-11" version="1">MGMCAPRDVRCPEVGDDGRRWRAHRGRIEPHGQGLPGQQATWGACFPGALPRRSEDAWGHSVPAWVRRLLLGNAMVPPTMSKRDKLQDSELVVAARALDAELARFESQAEQLEKAPLQSEKHLERASAMLQGLADLDEQLRGRVTALVGAISKVRDRQQAQAEAIHLRAQELQRRTEVFKDLLVRYGALGQNAGELNVQMQQFAQQRQAAKTPEENAALAGTFQALQERMSLVADEAHSLAQAAEEQAFLDVARQADSLRQQLLSARNKMSLLQKSFGGGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX25</accession>
    <name>Q1CX25_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556854.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6934"/>
    <dbReference type="EnsemblBacteria" id="ABF92218">
        <property type="protein sequence ID" value="ABF92218"/>
        <property type="gene ID" value="MXAN_6934"/>
    </dbReference>
    <dbReference type="GeneID" id="41364115"/>
    <dbReference type="KEGG" id="mxa:MXAN_6934"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_7"/>
    <dbReference type="OMA" id="MYEDALF"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="359"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="607" mass="66521" checksum="10841CA261F33BF8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX92</accession>
    <name>Q1CX92_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="6">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="6">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="6">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">msrBA</name>
        <name evidence="6" type="synonym">msrA</name>
        <name evidence="9" type="ORF">MXAN_6864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6864"/>
    <dbReference type="EnsemblBacteria" id="ABF92291">
        <property type="protein sequence ID" value="ABF92291"/>
        <property type="gene ID" value="MXAN_6864"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6864"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_7_2_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="8">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="407" mass="44698" checksum="98FA13088714A97B" modified="2006-07-11" version="1">MPGGRRPGATASETTWGPRAYTQKHPRSRELPETASMPTASTSSSLARRLMPLALAALAVLSACTEARGAAPAAPGPTIQDTRRYEKPSDADLRRTLSPLAYEVTQKGATEPAFRNPLWNHHEEGLYVDVVSGEPLFSSRDKFDSGTGWPSFTRPVDSARIVEKRDSTQGMERVEVRSKAAGSHLGHLFGDGPAPAKTRYCINSAALRFVAVNDLAKEGYGAWLPLFGRPAPAAATKRQDTSPFTETALLAGGCFWGMEDLLRKIPGVVQTEVGYTGGSSAFRNPTYHDVSSDKTGHAEAVRVVFDPTRLTYETLLEQWFFRMHDPTTLNRQGNDVGTQYRSAIFYLSDAQKRVAEEVKARVDASRKWPRPVVTQIVSAGAFTPAEDYHQDYLVKNPGGYTCHYMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX97</accession>
    <name>Q1CX97_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph</name>
        <name evidence="1" type="ORF">MXAN_6859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556784.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6859"/>
    <dbReference type="EnsemblBacteria" id="ABF87798">
        <property type="protein sequence ID" value="ABF87798"/>
        <property type="gene ID" value="MXAN_6859"/>
    </dbReference>
    <dbReference type="GeneID" id="41364048"/>
    <dbReference type="KEGG" id="mxa:MXAN_6859"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_7"/>
    <dbReference type="OMA" id="WAVPYGY"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23241" checksum="34118ACB1E98B0AA" modified="2006-07-11" version="1">MLLRAVIFDLDGTLVDSLGDIADATNHALAHHGLPTHPESAYLRFVGSGVRELIRRAVPSGQDALIEPVLASYKAYYDDHLFDRTAHYPGIPEMLTALAAQGTKLAVLSNKSDDFVKRLVARLLPQASFAAVYGERPELPRKPDPTAALALASELGVPPAACGFVGDTSIDMDTARAAGMYGVGVAWGFREVDELKAHGARAVAATAAELLAALRDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXC4</accession>
    <name>Q1CXC4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556757.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6832"/>
    <dbReference type="EnsemblBacteria" id="ABF90222">
        <property type="protein sequence ID" value="ABF90222"/>
        <property type="gene ID" value="MXAN_6832"/>
    </dbReference>
    <dbReference type="GeneID" id="41364021"/>
    <dbReference type="KEGG" id="mxa:MXAN_6832"/>
    <dbReference type="HOGENOM" id="CLU_1320256_0_0_7"/>
    <dbReference type="OMA" id="NNQHIQM"/>
    <dbReference type="OrthoDB" id="1188256at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="22906" checksum="E26A7A179187F05F" modified="2006-07-11" version="1">MGLYDSVAERLAFMKKMTPAELKKLGSARLSDIVLQEVARSRVRITTLEKRYPQAAPRELAQRIVDEKKNLASMVGGVSGVFGLVALPADLLFMAYLQIILLTDVATLYKVNLKTERARGEMLDLFGYANGLGPLPRAGPKVLGKLAAMLLEKGGMQTLGRAMPLVAAPVTAYFNNQHIQMVGEQAVRFYEGFDKAHAKAKAQRKKASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL0</accession>
    <name>Q1CXL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556671.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6746"/>
    <dbReference type="EnsemblBacteria" id="ABF93024">
        <property type="protein sequence ID" value="ABF93024"/>
        <property type="gene ID" value="MXAN_6746"/>
    </dbReference>
    <dbReference type="GeneID" id="41363938"/>
    <dbReference type="KEGG" id="mxa:MXAN_6746"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="SMKGAME"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="26744" checksum="215570AA94AF840A" modified="2006-07-11" version="1">MSTSKNMPVALITGGSRGLGRNMALKLAARGTGIILTYRTGADEAAAVVKQIEAAGGKAVALPLDVGDTRGFGAFVEAVRTELGRHFGRERLDFLVNNAGMGIQVSFAETTEAQFDALMNVHLKGTFFLTQRLLPVLADGGRILNISSGLARFTFPGHAAYATMKAGVEALTRYLAKELGARRISVNVLAPGATATDFGGGVVRDNPELNKTLAAQVALGRVGQPDDIGDAVAMLLSPESAWVTGQRIEASGGMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXP4</accession>
    <name>Q1CXP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556637.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6712"/>
    <dbReference type="EnsemblBacteria" id="ABF90847">
        <property type="protein sequence ID" value="ABF90847"/>
        <property type="gene ID" value="MXAN_6712"/>
    </dbReference>
    <dbReference type="GeneID" id="41363905"/>
    <dbReference type="KEGG" id="mxa:MXAN_6712"/>
    <dbReference type="HOGENOM" id="CLU_1364990_0_0_7"/>
    <dbReference type="OMA" id="EPRFHVE"/>
    <dbReference type="OrthoDB" id="1878968at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="22186" checksum="6090BCE04BAB2EFA" modified="2006-07-11" version="1">MRTRGEVAAVVLGIMLVGASASLLAPRWALGNQGAPREVARTPAAPPKVAAEPRFHVEPAKDDTGRAVQVASLRDEAPEWEQFAARALVPLTPDERALLQEEPVDDLAVLVTRTERAFMDATPEARMEKERRYLAALNLVAKLATPPEPSTEDLRAGEVDARYQQALTVEQVKWRSLPPEEKSRQHDAFKEAFFRAEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY57</accession>
    <name>Q1CY57_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556474.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6544"/>
    <dbReference type="EnsemblBacteria" id="ABF88904">
        <property type="protein sequence ID" value="ABF88904"/>
        <property type="gene ID" value="MXAN_6544"/>
    </dbReference>
    <dbReference type="GeneID" id="41363749"/>
    <dbReference type="KEGG" id="mxa:MXAN_6544"/>
    <dbReference type="eggNOG" id="ENOG5033CR9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091669_0_0_7"/>
    <dbReference type="OMA" id="ERVGHYR"/>
    <dbReference type="OrthoDB" id="1313509at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="26799" checksum="01B5AEEE9F980181" modified="2006-07-11" version="1">MLLSDVAADGRPRTKKPAARRSPPRTTRLARYFDLHDDFRIPGRPELSDPVAVDVRRKLDSVWLFTSGARVRSVGKLRLAVTPPGLPLDFSLAGAGLTPVVSARVASVFRELAPDDVQLLPVEVEDRDEPHFILVATRLVRCIDDRACEEVIHYTAEDGLPERVGHYRNVRGLRVDPTKTNGARVFRTWGWPVSLIVSEGIKEALEHAGIAGARFAEVTKPPRKPRRKKTAAKKSRPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY85</accession>
    <name>Q1CY85_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556446.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6515"/>
    <dbReference type="EnsemblBacteria" id="ABF89357">
        <property type="protein sequence ID" value="ABF89357"/>
        <property type="gene ID" value="MXAN_6515"/>
    </dbReference>
    <dbReference type="GeneID" id="41363723"/>
    <dbReference type="KEGG" id="mxa:MXAN_6515"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099590_2_0_7"/>
    <dbReference type="OMA" id="VERSDFR"/>
    <dbReference type="OrthoDB" id="1472440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="17897" checksum="314BFA89A4B73B54" modified="2006-07-11" version="1">MPPAPLCPCSSGLRYRECCAPFHRGEAEPPDAERLMRSRYSAFALREVAWLWKTLHPHHPDRARPQDEVLRELRAFAQAHQYPKLVVMDRREPDADGLAQVLFFAKVFEKGKDRSFVERSDFRHDGTGWRYLSGVALAPKELAVPPESLTLATFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYP8</accession>
    <name>Q1CYP8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556283.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6351"/>
    <dbReference type="EnsemblBacteria" id="ABF86803">
        <property type="protein sequence ID" value="ABF86803"/>
        <property type="gene ID" value="MXAN_6351"/>
    </dbReference>
    <dbReference type="GeneID" id="41363565"/>
    <dbReference type="KEGG" id="mxa:MXAN_6351"/>
    <dbReference type="HOGENOM" id="CLU_2002516_0_0_7"/>
    <dbReference type="OMA" id="QAWRMTK"/>
    <dbReference type="OrthoDB" id="1623473at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021866">
        <property type="entry name" value="SpoIIAA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038396">
        <property type="entry name" value="SpoIIAA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11964">
        <property type="entry name" value="SpoIIAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="125" mass="13913" checksum="E6825F1489B7F60A" modified="2006-07-11" version="1">MPFQITVHSQDRILEVVYPPQVTTADLAEYLADVKKAINDLAGEWSALVDQSQLRVMPSDVVTAMASLNAFAQLHGMKRSARVVSDAPSGLQAWRMTKRAMLSIPTRTFETRGEALQWLRDPDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYW5</accession>
    <name>Q1CYW5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556219.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6281"/>
    <dbReference type="EnsemblBacteria" id="ABF88861">
        <property type="protein sequence ID" value="ABF88861"/>
        <property type="gene ID" value="MXAN_6281"/>
    </dbReference>
    <dbReference type="GeneID" id="41363500"/>
    <dbReference type="KEGG" id="mxa:MXAN_6281"/>
    <dbReference type="eggNOG" id="COG1378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_1_1_7"/>
    <dbReference type="OMA" id="FVIDRRW"/>
    <dbReference type="OrthoDB" id="1036370at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="108"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="30082" checksum="F597DE83C0AC2154" modified="2006-07-11" version="1">MDADEGLVALGFTEVEARVYCELLKGAPATGYRLAQALGKAPPSIYQALASLEHKGAVLVEEGEPRSFRPVPPDEVLTALQRGFDTRRREAADALRKLHAPVQDDRIYHLKSHAQVMERARAMIAGATERLLFDLFPPPLAALAPALTEASARRVSVVGLVYDEPPKAPFASVRSSSADFVRERWPGAQLTLVVDAREFLVALLTPDGTGVKQAIWSDSVYLSCLQHSGLAAEIQLSAPPSARARMARSFSLINSSPPGLRQLVGRQPRSSSKRGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ25</accession>
    <name>Q1CZ25_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_6217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6217"/>
    <dbReference type="EnsemblBacteria" id="ABF87846">
        <property type="protein sequence ID" value="ABF87846"/>
        <property type="gene ID" value="MXAN_6217"/>
    </dbReference>
    <dbReference type="GeneID" id="41363444"/>
    <dbReference type="KEGG" id="mxa:MXAN_6217"/>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529486_0_0_7"/>
    <dbReference type="OMA" id="EYHRNGR"/>
    <dbReference type="OrthoDB" id="1303349at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="22068" checksum="506762E7D88792BF" modified="2006-07-11" version="1">MQLKKRVLTGAVRVLVAGMALGCNRASGPCPDGAQLQGRAPPDGVLQWCARPDGKKHGRWAEWHATGALKTEGTYVDGKMEGRWVSYFEDGVKQFEGDYRGGLKQGLWTLYYEEGQKNREELHSPGSGPVKWTAWRSDGSKWAEGTLAGHRSQGAYSEWHPHGALAVQGQYEKGEKTGEWKYWDVAGVATDVPQGDFDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ63</accession>
    <name>Q1CZ63_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF86083">
        <property type="protein sequence ID" value="ABF86083"/>
        <property type="gene ID" value="MXAN_6179"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6179"/>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535176_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="577" mass="61930" checksum="21C2A701D4D3EB81" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ72</accession>
    <name>Q1CZ72_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, aldo/keto reductase family</fullName>
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        <name evidence="3" type="ORF">MXAN_6170</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
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    <dbReference type="STRING" id="246197.MXAN_6170"/>
    <dbReference type="EnsemblBacteria" id="ABF86533">
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        <property type="gene ID" value="MXAN_6170"/>
    </dbReference>
    <dbReference type="GeneID" id="41363400"/>
    <dbReference type="KEGG" id="mxa:MXAN_6170"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_7"/>
    <dbReference type="OMA" id="FGCSTFP"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
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        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="37712" checksum="92CAB0B835E16875" modified="2006-07-11" version="1">MEYASILGISAPASRVGLGTWAMGGSQWGGTNDDESVRTIHAALDLGITLIDTAPAYGFGHSEKVVGRALAERGGREKVVVATKVGLERRGDGVIRNSSRQQVIQELEVSLRHLRTDYVDLYQVHWPDFSTPYEETAQALLDLQRAGKIRAIGVSNYSIEAMERFRSVAPLASAQPPLNLFEREALEDIIPWCRTNGVATLTYGALCRGLLTGTMNKDTRFEGDDLRQTDPKFLPPRYAQYLQAVQRLAQFARERYDKGVLPFAVRWVLDQPGVTVALWGARHPGELEPLRDVIGWRLDDEALTYTDSVVNESVPEPVGPEFMAPPEQRPEESGERPGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZD6</accession>
    <name>Q1CZD6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556051.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6102"/>
    <dbReference type="EnsemblBacteria" id="ABF87949">
        <property type="protein sequence ID" value="ABF87949"/>
        <property type="gene ID" value="MXAN_6102"/>
    </dbReference>
    <dbReference type="GeneID" id="41363336"/>
    <dbReference type="KEGG" id="mxa:MXAN_6102"/>
    <dbReference type="eggNOG" id="COG3372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681354_0_0_7"/>
    <dbReference type="OMA" id="VMIPDFR"/>
    <dbReference type="OrthoDB" id="1178381at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="DUF790"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="PTHR39640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="44719" checksum="22C6393CA11383AA" modified="2006-07-11" version="1">MLTRELLNFRVRQGVLRPVFVKRDDTELLTFAQDLLAEVAASRGGQRDDIEESLGLKAGAFTKPKVARGLVKLVLDRLLFDEPAPGVTEARWERIKAAGQVLRALPPDATVEGFEARLAQTLPVPLSEAREALYSDLPGHRRLVGWDGEALNAQDLLDRYNLALAQGPLLSARRLRLRAQAPDLLRVRKVLRWLKFCRLVAEVWRDDDNWALDVEGPGAMLALQKKYGLQLATFLSVVPVLERWELTATVELSRRQATLMLSHKDPLRSPLPAALGHIPPEVASLAEGFADDAWELDLTPLPRHVGASGLCVPDLTFRHRASKREVALELFHAWHAAPLARRLTELRSRPDAGLLLGVDRALAKEAVEREALEAHPQVVLFNGFPSARKLRERLAKLEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZU1</accession>
    <name>Q1CZU1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555896.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5945"/>
    <dbReference type="EnsemblBacteria" id="ABF88915">
        <property type="protein sequence ID" value="ABF88915"/>
        <property type="gene ID" value="MXAN_5945"/>
    </dbReference>
    <dbReference type="GeneID" id="41363184"/>
    <dbReference type="KEGG" id="mxa:MXAN_5945"/>
    <dbReference type="HOGENOM" id="CLU_2058841_0_0_7"/>
    <dbReference type="OMA" id="DWQVDSL"/>
    <dbReference type="OrthoDB" id="2197664at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="12137" checksum="EA6EC180C503C0DC" modified="2006-07-11" version="1">MQTTLLSRPIDVPWRTAALSSAAVLTASNVAALVASLRLAPLLRHRLRPRPRALPALAVGATALGALAIGALSIGTLAIRALTIGKLRGDDWQVDSLRVGSLQVVETIGPTGSSGVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D053</accession>
    <name>Q1D053_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5833"/>
    <dbReference type="EnsemblBacteria" id="ABF91136">
        <property type="protein sequence ID" value="ABF91136"/>
        <property type="gene ID" value="MXAN_5833"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5833"/>
    <dbReference type="HOGENOM" id="CLU_3218991_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4873" checksum="040819416EBDC608" modified="2006-07-11" version="1">MRATSLAPSALWEFAGGVDWGNCQDVANTICERTAYGACWNWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D058</accession>
    <name>Q1D058_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SpoVR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555779.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5828"/>
    <dbReference type="EnsemblBacteria" id="ABF87192">
        <property type="protein sequence ID" value="ABF87192"/>
        <property type="gene ID" value="MXAN_5828"/>
    </dbReference>
    <dbReference type="GeneID" id="41363068"/>
    <dbReference type="KEGG" id="mxa:MXAN_5828"/>
    <dbReference type="eggNOG" id="COG2719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010179_1_0_7"/>
    <dbReference type="OMA" id="NSNPCYA"/>
    <dbReference type="OrthoDB" id="507759at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="497" mass="59073" checksum="B29EB2D3C5837A4F" modified="2006-07-11" version="1">MPKSLPPRLASLRDEIHGYAKEFGLDFFDTHFEMVSYDEMNMVAAYGGFPTRYPHWRWGMEYEQLAKGYEYGLSKIYELVINNDPCYAYLMESNPEVDQKLVMAHVYGHCDFFKNNFSFRHTNRRMIDEMANHATRVRRWVDKIGVEKVEDFIDRTLSLENLIDQHAPHIRRNPDPKKAEDELKANERVEGFKVDREYMRGYINPSEFLDSQRKKVEDEKQRAKKFPERPQRDVLLFLLEEAPLEPWEADILAILRDEAYYFAPQGQTKIMNEGWASYWHSTIMTRRALKDDEIIDYADHHSGTMGTRPGAINPYKLGIELWRDIEERWNKGRFGKEWDECDDLRARRAWDKKLGAGREKIFEVRKHYNDITFIDTFLTPEFAMEQKLFVYGFNDKRNSWEILDREFKKVKNKLLQGLTNFGQPIIEVVDGNFENRSELLLAHRHDGQDLKGDYARETLRNLQSLWRRPVNILTRYDNKGVILRFDGQSHSERKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D076</accession>
    <name>Q1D076_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555761.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5810"/>
    <dbReference type="EnsemblBacteria" id="ABF88587">
        <property type="protein sequence ID" value="ABF88587"/>
        <property type="gene ID" value="MXAN_5810"/>
    </dbReference>
    <dbReference type="GeneID" id="41363051"/>
    <dbReference type="KEGG" id="mxa:MXAN_5810"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_7"/>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26306" checksum="8BDB1AD5C8F26841" modified="2006-07-11" version="1">MLLLAHRGASADAPENTLEAFAEAVRQGADGVELDAMLCGSGEVVVCHDERLERLARLPWEVRLTPWWKLQRADVGSPLGFAPARIPLLEEVLEALPPQFLVNIELKCERADDGGLAEQVARLVRRRGLAGRVVISSFNPLCLFRLAAAAPELRRGLLIDPDKSWALQAYGVSPLVSSHSVHPFHEACTPERVAAWRAAGMSVAAWTVDDPQRAHVLERMGVSYLITNRPGAVRQALHPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0F6</accession>
    <name>Q1D0F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative type II restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5729"/>
    <dbReference type="REBASE" id="13177">
        <property type="entry name" value="MxaDKMrrP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86946">
        <property type="protein sequence ID" value="ABF86946"/>
        <property type="gene ID" value="MXAN_5729"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5729"/>
    <dbReference type="eggNOG" id="COG4127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047680_0_0_7"/>
    <dbReference type="OMA" id="DWVITYS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016984">
        <property type="entry name" value="UCP031853"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031853">
        <property type="entry name" value="UPC031853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="201"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="37966" checksum="54D018FEA5E894E9" modified="2006-07-11" version="1">MVTANKRLWFIRAGRDAAFFDAFKAEGHVGIGWDKVGPLAPDLSADELEARFAKAYPEDKEGTRRVWAAQVRRFMRDVEQGDSAVTYDPNERVYLLGRIESGVENRAGPPPLVRRVRWTHHVLRNQLSAATRNGLGSIATLFRPSAEATAELWAQAVELERPVASLAPTPAPAVDSDEGTEAVLREEQFEKAEQFIEDRIARLNWSEMQELVAGILRAMGYRTRVAAPGADRGVDIFASPDGLGLQEPRIFCEVKHRVGESMNSQSIRAFLGGRKQGDRCLYVSTGGFTKDARYEADRSSVPLRLLTLSDLRELLVEQYENLDAETRALVPLKKLYWPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N7</accession>
    <name>Q1D0N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type III secretion apparatus protein YscR/HrcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5647"/>
    <dbReference type="EnsemblBacteria" id="ABF87970">
        <property type="protein sequence ID" value="ABF87970"/>
        <property type="gene ID" value="MXAN_5647"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5647"/>
    <dbReference type="eggNOG" id="COG4790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042028_2_0_7"/>
    <dbReference type="OMA" id="IMITCFP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005773">
        <property type="entry name" value="YopR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01102">
        <property type="entry name" value="yscR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="23481" checksum="62EF838955AFCCA1" modified="2006-07-11" version="1">MSYAGSPLSMMGMLAVMSLLPFAVLMLTSFSKIAVVLSLARSAMGTQQAPPTIVLTGLAAVLTGHIMAPVMERMYDAGQVAYAEVASGSGAEMLSAASRVSEPLRAFLIKHGSAEERARFVDLARELRPVEEMDAVRETDLFIVIPAFVITELKEAFQIGFLVFLPFLVLDMVIANVLLALGMQTLSPSQVSLPFKILLFVAVDGWSLLARGLILGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0X4</accession>
    <name>Q1D0X4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555514.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5560"/>
    <dbReference type="EnsemblBacteria" id="ABF85887">
        <property type="protein sequence ID" value="ABF85887"/>
        <property type="gene ID" value="MXAN_5560"/>
    </dbReference>
    <dbReference type="GeneID" id="41362808"/>
    <dbReference type="KEGG" id="mxa:MXAN_5560"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073827_0_0_7"/>
    <dbReference type="OMA" id="ERRDEAW"/>
    <dbReference type="OrthoDB" id="1469969at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187998" evidence="6">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="137"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="28520" checksum="70146F85748A656F" modified="2006-07-11" version="1">MARGLVPVIQLLALVAAPVAGAQSASQGATLFTQRCATCHTVGEGDRVGPDLHGVMERRDEAWVTRFITSPGAVIDEGDPVANALLKQFNGIRMPDQQLAPEELGALYAFFRDCTKKGEGGCKPSPAAKMGTDATSEEVARGRRLFEGTEALAKGGPACFGCHDVRGLGVAGGGTLGPNLTFAFARMGERGMRPLLAKLDTPMMAALYAKAPLEEEEQYALKAYLADVSRDGSKPRTDRDFFYLGLVGMLAVLGFMGVAFNAHTKRGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Y9</accession>
    <name>Q1D0Y9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5545"/>
    <dbReference type="EnsemblBacteria" id="ABF86455">
        <property type="protein sequence ID" value="ABF86455"/>
        <property type="gene ID" value="MXAN_5545"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5545"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_2_7"/>
    <dbReference type="OMA" id="HLVNLCW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26337" checksum="94295A1A20D1B65A" modified="2006-07-11" version="1">MRGSNSTGELPVGRFRLGKLLLSRLEVNVATKKRLSGADRRVQLMAVGRGVFASKGYEATSIEEVAHQAGVSKPIVYEHFGAKEGLYAAIVDREMDDLVTRVSESIASGTPRERFERAVLAFMTYAKEEPAGFAVMTRDSPLAAGRRGLTRVIDDLALRVSDIFKSEFEHAGYNPKVAPIYANALVGMVTQVGQWWAEDGRSFSIDHVARHVAALGWMGLRHLPKEPAASNGRRGAKRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D168</accession>
    <name>Q1D168_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555420.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5462"/>
    <dbReference type="EnsemblBacteria" id="ABF92952">
        <property type="protein sequence ID" value="ABF92952"/>
        <property type="gene ID" value="MXAN_5462"/>
    </dbReference>
    <dbReference type="GeneID" id="41362718"/>
    <dbReference type="KEGG" id="mxa:MXAN_5462"/>
    <dbReference type="eggNOG" id="ENOG5031XNT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155440_0_0_7"/>
    <dbReference type="OMA" id="HGRTIIN"/>
    <dbReference type="OrthoDB" id="1159246at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="27990" checksum="353EA43FC687D3CA" modified="2006-07-11" version="1">MPDYVHVLLGLVLGYVISSYVESFMHEYVSDARPKAVRFWNRAPRLFRPMINTHFSHHTIHHVRTFRSNHVTQFRSEEEKQKLTEELLQRGKHGRTIINGAFATRLHGEGAFVFVAPLVIFFPVFYFTLKPIAFLAGCVTLLLPPFMSHFVHPYLHMPFEEGQRTAPRWLAWLLRTRYMRAVYRNHFLHHRYGGVSNFNLVLGADIVRRRTRVLTEKDLSVMAEVGMPLPEEAPTRTVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D183</accession>
    <name>Q1D183_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87155">
        <property type="protein sequence ID" value="ABF87155"/>
        <property type="gene ID" value="MXAN_5447"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5447"/>
    <dbReference type="HOGENOM" id="CLU_3063778_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="53" mass="5775" checksum="CC55C62D37D9668B" modified="2006-07-11" version="1">MKHSQPDGTTHLLFTGLELLRRLASLVPPPRLGQTSRGSTVSSLTPRAMFRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1J7</accession>
    <name>Q1D1J7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555291.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5326"/>
    <dbReference type="EnsemblBacteria" id="ABF91774">
        <property type="protein sequence ID" value="ABF91774"/>
        <property type="gene ID" value="MXAN_5326"/>
    </dbReference>
    <dbReference type="GeneID" id="41362595"/>
    <dbReference type="KEGG" id="mxa:MXAN_5326"/>
    <dbReference type="eggNOG" id="COG4247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044211_0_0_7"/>
    <dbReference type="OMA" id="GLTIYYA"/>
    <dbReference type="OrthoDB" id="1018030at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:3-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="BP_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188261" evidence="2">
        <location>
            <begin position="21"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="42274" checksum="361301EBDA4BCC66" modified="2006-07-11" version="1">MRNPTPLALAALLLGTPVSAQVSVSPTAQSEPAPSITGGVLQDVALWVSPGAPSSSLFLTAYNSPNAGLVTFGLGGEQLDAELTDGPMSAVAVRDGFPLSGVQQTLVVAASINFNGLAAYTADPDRAERVERIGAAGFLTGTQFSAVALYQNEDSGRFYVFAGTSTGVLRQYELAGDTGSVTATLVRTLATTGPIAGLAVDEASDSLFVTQQGQGLWRYPAAADAGATGQQLSIQGSGGLSANVGRVALYRARNGEGYILVADTGADAFAVYERRARTLVGSFRLADEDGGVIRANDPVALAVTASSLGTTYPDGLFVGSDAFSNPQRFLYARWPAVAEAFDPALRIDTRFDSDGGTDGGTDGGPGDGGGSGGPGPAPGPGNRPDESGCSCASASVPATAAFALLALVRVGRRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1K5</accession>
    <name>Q1D1K5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative daunorubicin resistance ABC transporter, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555283.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5317"/>
    <dbReference type="EnsemblBacteria" id="ABF91267">
        <property type="protein sequence ID" value="ABF91267"/>
        <property type="gene ID" value="MXAN_5317"/>
    </dbReference>
    <dbReference type="GeneID" id="41362586"/>
    <dbReference type="KEGG" id="mxa:MXAN_5317"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="ICGFDVQ"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="35921" checksum="4559556784DC96F0" modified="2006-07-11" version="1">MPEVLLSTATSQPLLQLEGLTRRFKGRTAVDGLSLSVRPGEILGLLGPNGAGKSTTFQVLAGLLSPDAGLVRFEGRELSLSDPSLRRQMGIIFQRSSLDDLLTARENLMLGARLYGLGGERARERVEAMLSLIGLADRGDERVSTWSGGMRRRLELARALVHQPRVLLMDEPTQGLDEAAFRTFWAHLKRLRDSEGLTVLLTTHRADEADVCDRLAVLDAGKLVACDTPQALASRMGGDILSVEALEPEALATELRERLKLDAKVVEGRVQVEAPRGHALVPRLVEAFPAGRLTSVALRRPTLADVFLQLTGRALGADVPTAEPAPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Q6</accession>
    <name>Q1D1Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5265"/>
    <dbReference type="EnsemblBacteria" id="ABF88956">
        <property type="protein sequence ID" value="ABF88956"/>
        <property type="gene ID" value="MXAN_5265"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5265"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_335495_0_0_7"/>
    <dbReference type="OMA" id="THAFDEN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="513"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1047" mass="113862" checksum="9033EDB61FF4303F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V3</accession>
    <name>Q1D1V3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555185.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5218"/>
    <dbReference type="EnsemblBacteria" id="ABF88569">
        <property type="protein sequence ID" value="ABF88569"/>
        <property type="gene ID" value="MXAN_5218"/>
    </dbReference>
    <dbReference type="GeneID" id="41362500"/>
    <dbReference type="KEGG" id="mxa:MXAN_5218"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528649_0_0_7"/>
    <dbReference type="OMA" id="YDEGVYF"/>
    <dbReference type="OrthoDB" id="1483138at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="54007" checksum="2A7EDB8522386EBB" modified="2006-07-11" version="1">MRSSNLSTPRLHLSWWPLVLIASGAWLLRIAGFFHRGGAFGHAVDYDEGVYFSAAALLSHGVLPYRDYFFVHPPGIAMLLAPVAALARGFDAALAFAVVRWLVPGIGALSTLLCGRIAQEQWGVRAGVVAALAYAVFPEAAATERGPFLEPLLNLACLGMAWVWLRHGADVSRWKGDLLAGALLATACAIKLTAGAWVIAAVWARGMEGQGRRALRVVLVAAAVGLVWLGPFFALAPAAMLDGLLRFQLLRPPDGESDVWRRLLMVLGDGRMGFSVLCVWGLVVALARTRRREAVAERLFAAAWVLTLVTFLSSKSYWAQYNANLAPTMAVLAGLGASVVLSWADTRSRTQAALVTATVMLIALSPLPAAIRSANQRDRFLLTLGSSLRASVPPDSALCTFEPAWAIAAGRLPGIPEGTPILVDPYGLMLNDALGTPGRFAHAGAAFEDERSQRTMLPMLARCDILVLEGRGEWQLSSASERWVHEHFVREGLFWRRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D268</accession>
    <name>Q1D268_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555075.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5101"/>
    <dbReference type="EnsemblBacteria" id="ABF87036">
        <property type="protein sequence ID" value="ABF87036"/>
        <property type="gene ID" value="MXAN_5101"/>
    </dbReference>
    <dbReference type="GeneID" id="41362385"/>
    <dbReference type="KEGG" id="mxa:MXAN_5101"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102127_0_0_7"/>
    <dbReference type="OMA" id="WLQSRMA"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011517">
        <property type="entry name" value="RNA_pol_sigma70_ECF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07638">
        <property type="entry name" value="Sigma70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02999">
        <property type="entry name" value="Sig-70_X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="20590" checksum="37E58CE0F3C3B58F" modified="2006-07-11" version="1">MSELTELLDHARKGEQGARDALMAAAYQELRDMVQRAMSDAASTPSLQPAVLVKEAWLRLFSAGAPVEARRHFFSAAAQAMRRVMVDRVRLRRAQVREARLERVSLGDVEADVPAGLSLEVLELDRALSELDTFQPRLARMLELRYFVGLDLLDTAAVLSVSPVTVKRDWAYVREWLLTRLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D275</accession>
    <name>Q1D275_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase-like monooxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555068.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5094"/>
    <dbReference type="EnsemblBacteria" id="ABF88535">
        <property type="protein sequence ID" value="ABF88535"/>
        <property type="gene ID" value="MXAN_5094"/>
    </dbReference>
    <dbReference type="GeneID" id="41362378"/>
    <dbReference type="KEGG" id="mxa:MXAN_5094"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_1_7"/>
    <dbReference type="OMA" id="APGSDQM"/>
    <dbReference type="OrthoDB" id="1003376at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="338" mass="36408" checksum="D484FDB2FC452204" modified="2006-07-11" version="1">MIPFSVLDLSPVTQGSTAADALRNTLDLARHAEDWGFKRFWLAEHHNMTGIASAATSVVIGYVAGGTKRIRVGSGGVMLPNHAPLIIAEQFGTLETLYPGRIDLGLGRAPGTDMLTARALRRDLAASADTFPQDVVELKSYFEPTEPGQLIQAVPGAGLKVPIWLLGSSLFSAQLAAMLGMPFAFASHFAPDALLQALDIYRERFKPSESLERPYAMACVNVFAADTDAEAQRLFTSVQQQFIRLRRGTPGQLPPPVDDIDSVASPLDRASADHALKYSIIGAPDTVQQGLAAFIRLTGVDELMVTGMVYDHAARLRSFELTAQAHQRLAEAEAAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D277</accession>
    <name>Q1D277_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ORF">MXAN_5092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555066.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5092"/>
    <dbReference type="EnsemblBacteria" id="ABF92187">
        <property type="protein sequence ID" value="ABF92187"/>
        <property type="gene ID" value="MXAN_5092"/>
    </dbReference>
    <dbReference type="GeneID" id="41362376"/>
    <dbReference type="KEGG" id="mxa:MXAN_5092"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_7"/>
    <dbReference type="OMA" id="GPEHILM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="411"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF92187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="874" mass="97019" checksum="026D4EF4BC62440F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2A8</accession>
    <name>Q1D2A8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555036.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91917">
        <property type="protein sequence ID" value="ABF91917"/>
        <property type="gene ID" value="MXAN_5061"/>
    </dbReference>
    <dbReference type="GeneID" id="41362344"/>
    <dbReference type="KEGG" id="mxa:MXAN_5061"/>
    <dbReference type="HOGENOM" id="CLU_868268_0_0_7"/>
    <dbReference type="OMA" id="LMATHYL"/>
    <dbReference type="OrthoDB" id="680649at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="393" mass="42964" checksum="42EF144225CB1060" modified="2006-07-11" version="1">MPQRRWPLRSAPAPKGRGRRRSAPRTRSAGTGGPAHAVRPCLPWPGVVSVSGGAPITLEHGAASLVGIRVEELMAYGIANHLWIHGSPDRSRVRQWMDAALGTSFGEQPRSDIVVADVFQFRPALTLIDVQVLGAPRVEGEAEAAEQDGFLTRVASLAKEAGFKSTRVWMGEVGTMAWELESQDEEGVPVGAKREDEALRTLGADGWTVDPLAPVVAREVIRSIVKLPLEEVHHYIDWAVSCRSSMAAGTPVEGFNLTRASRLMATHYLVWKGTVLPKPTPVSEMAPKLGRARRMRRAATLVPAARVWGLVLLVAFVVPAVLYHFIFAPPVESPVKGFVLSGVMTLVWALFALVRFDDFQGRPVRLPWRLALFVGGQLVVGALMWWLHGMPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E7</accession>
    <name>Q1D2E7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="6">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fni</name>
        <name evidence="8" type="ORF">MXAN_5021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554997.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5021"/>
    <dbReference type="EnsemblBacteria" id="ABF91159">
        <property type="protein sequence ID" value="ABF91159"/>
        <property type="gene ID" value="MXAN_5021"/>
    </dbReference>
    <dbReference type="GeneID" id="41362306"/>
    <dbReference type="KEGG" id="mxa:MXAN_5021"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_7"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="181"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="352" mass="36759" checksum="17929E47DE40DC6F" modified="2006-07-11" version="1">MGDDITARRKDAHLDLCSTGDVEPSGNSTLLECVKLVHCAMPEMSVEDVDLSTAFLGKRLRYPLLVTGMTGGTERAGAVNRDLALLAERHGLAFGVGSQRAMSEDASRAASFQVRQVAPTVALLGNIGMFQAIGLGVDGTRRLVDGIGADGLALHLNAGQELTQPEGDRDFQGGYRVVELLVKAFGDRLLVKETGCGIGPDVARRLVDLGVRNIDVSGLGGTSWVRVEQLRASGVQAQLGAEFSAWGIPTAAALASVRRAVGPDVHLVASGGLRTGLDAAKVLALGANLAGMALPLFRAQQAGGLEAAEAALEVILASLRQALVLTGSRSCAELRQRPRVVTGELKDWLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D315</accession>
    <name>Q1D315_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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</entry>
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    </evidence>
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</entry>
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            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="288" mass="31875" checksum="5E693EBAC3CEBE44" modified="2006-07-11" version="1">MHDALQMEDWGGTGPVLHLAHANGFPPGCYRKLIEHLKPRYHVFTLRTRCLVPGSDPRELRTWDDMADDLIHALRAHGVQGVVGVGHSMGGVATLLASAKAPALFRAVVALDPVLFTGAREWALRALTLLGLRSRVPPASLARRRRESWGAREEAARSYGKKPLFARFDPECFQDYITHGLTEAPSGGFRLTIPKAWEARVFETSPKDVWRELGTVNVPSLVIRGGESDTLTRDALERARLTLNDPQTEELPGTGHLFPLEQPERCAQRIVEFLDGLESARAAARAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z1</accession>
    <name>Q1D3Z1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554459.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D3Z1"/>
    <dbReference type="STRING" id="246197.MXAN_4461"/>
    <dbReference type="EnsemblBacteria" id="ABF93104">
        <property type="protein sequence ID" value="ABF93104"/>
        <property type="gene ID" value="MXAN_4461"/>
    </dbReference>
    <dbReference type="GeneID" id="41361771"/>
    <dbReference type="KEGG" id="mxa:MXAN_4461"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039039_0_0_7"/>
    <dbReference type="OMA" id="VWEVVPE"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF93104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="420" mass="42118" checksum="2DCE52B8D511D1A6" modified="2006-07-11" version="1">MPKNLLVADDSLTIRKVIGMIFATEDFQVTAVDNGLDAISRTRELRPDVVLADVMMPGKSGYEVCEALKNDPATQGIPVVLLAGTFEAFDENRARAARADDHVTKPFESQVLLDKVKALVGQKSNTMPASAATQVRHAAPQPAAAPAPVAAAAPPGARPAPPPGARPGVPPGPGVPRPPGAGVPPPGARPPGPGMPPGMARPPGPGMPPPGAPGAPRPPGPGMPPGMARPPGPGVPPGARPPGPGMPPGARPGVPPPPGGPAPGLPPRPGMPPGAVARPGVPPPPGGPAPGGFARPPVGAPQPPPGAAPQPAARGRDPFGLGAPAPAAAQPSISIEDSLPDQGDAEEISLDIATPAPVAARPASARAPAADGGEALLREALSKASREVIEKIAWEVVPQLAETIIREELERLIKDRETQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D415</accession>
    <name>Q1D415_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554436.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4437"/>
    <dbReference type="EnsemblBacteria" id="ABF87504">
        <property type="protein sequence ID" value="ABF87504"/>
        <property type="gene ID" value="MXAN_4437"/>
    </dbReference>
    <dbReference type="GeneID" id="41361749"/>
    <dbReference type="KEGG" id="mxa:MXAN_4437"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143437_0_0_7"/>
    <dbReference type="OMA" id="VHRTRWT"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14090" checksum="B07B71F87804A408" modified="2006-07-11" version="1">MDVQGFHHVAIQARDIERVTGFYRDLLGFPELTRHLRPDGSLRSIWVGVPGGGFLAIEAAGGEPVSTPFRHEAPGLLLLAFRIPKAARAGVVDTFTRAGVPLENETRWSVYVRDPEGNRVALSHHPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B1</accession>
    <name>Q1D4B1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent trancsriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554340.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4339"/>
    <dbReference type="EnsemblBacteria" id="ABF88909">
        <property type="protein sequence ID" value="ABF88909"/>
        <property type="gene ID" value="MXAN_4339"/>
    </dbReference>
    <dbReference type="GeneID" id="41361651"/>
    <dbReference type="KEGG" id="mxa:MXAN_4339"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="ERANKGT"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="150"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="459" mass="50438" checksum="B232195F86AA4D27" modified="2006-07-11" version="1">MSHTERPQGAGRPAEGPDSVQQTRPTGTGRPGTSGAVRRFRFTVLEGPQPGQSKDSNADTFSIGSHGLNDFVIEEPTVSRFHCEVKVDHDGARLRDLDSRNGTVLDGVHVRDAYLRGGSILRLGRVSVRFDFSPETNRLLISDRTTFGELVGSSPVTRASFALMERAAASDATVLLEGETGTGKSRAAFAIHQASARASGPFLTVDCGAIPGNLLESELFGHEKGSFTGAIQRRVGAFEEADGGTIFLDEIGELPAELQPKLLRVLENKEIRRLGANGYQPVNVRVIAATHRDLRAEVNAARFRSDLFFRLAVVRIIIPALRERPEDIPLIAERILMAFGAGSEQLAALSTPEFIAQLQHAAWPGNVRELRNHLERCLVFQDAMPPDAEEVSAQAVLRSLVDPKQPYAEARRRALEVFEREYLDALLKLHGGKVSQAATAADMDRVYLYRLLRRHRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4L6</accession>
    <name>Q1D4L6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554235.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4232"/>
    <dbReference type="EnsemblBacteria" id="ABF86281">
        <property type="protein sequence ID" value="ABF86281"/>
        <property type="gene ID" value="MXAN_4232"/>
    </dbReference>
    <dbReference type="GeneID" id="41361549"/>
    <dbReference type="KEGG" id="mxa:MXAN_4232"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_7"/>
    <dbReference type="OMA" id="RCANTQF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="158"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="45717" checksum="BD1FFEC64103A4D7" modified="2006-07-11" version="1">MEAIPPAPPRILIVDDDDSVRDVISVLLREEGYNCVVANGAEMALDLAGEEETPLVISDMKMPGKDGLWLLENLRERLPDTSVIMLTGYGDTESAVDCLRRGAVDYLLKPPKLTDLIRAIERALAKRRIEMARKRYQKKLERKVRDRTAELRSALRDIANTYQNTLLALVAALDAREHETSDHSQRVVSYTSAIAQRMGIQGKELEEIGRGALLHDIGKIGVPDAVLLKPGKLTPDEWLEMRKHPDIGFQMIQAIPFLDTPASIVLSHQERWDGAGYPRNLQRHEIHIGARIFAVADTLDAMTSDRPYRKGTTFTNAIQEIKRCANTQFDPEVVRAFLDIGEEGLIRIKQEMATKKLQLPQAEQDAHDAEAELARLTDLDDDVDAAVPGHSASDEDEPKSAVVRSVAGNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Z1</accession>
    <name>Q1D4Z1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554110.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4104"/>
    <dbReference type="EnsemblBacteria" id="ABF91897">
        <property type="protein sequence ID" value="ABF91897"/>
        <property type="gene ID" value="MXAN_4104"/>
    </dbReference>
    <dbReference type="GeneID" id="41361433"/>
    <dbReference type="KEGG" id="mxa:MXAN_4104"/>
    <dbReference type="eggNOG" id="ENOG5032E77">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747686_0_0_7"/>
    <dbReference type="OMA" id="STYGEMY"/>
    <dbReference type="OrthoDB" id="609678at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="370" mass="40549" checksum="073650B36F5F5F84" modified="2006-07-11" version="1">MDNRGRRRVWLVVAAMLFVVAAVLMFTGQGEEPAMETPKVEFPRRMRAPERERAERRRTHVMPVQVDAGTQERARPRDPLLAALPRGEGKTAVVIEANALRHSPIGELLLDCLMRDGGKRLQELRNLSGVDPLQDLDRLVITDEGMMLSGNFGNAKFKELLGERVSMDYGEGARVYEPGDMTVTRPDGSTARGRSEAAVATWNNELLVIGKSPDEVKAVVDRVEGRGPDEPPAISEGSTYGEMYGVLSVDQLARLLPKEQAELADRIRRVAQNVELHVDASGDVAMVAEVRGANGDEVTDLGKTLGAALSMARIKAQAEGEKDLAQLLDFARVQPDGTSFKLEMAVPLDVIKQRLAFCKEERSAAEAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D528</accession>
    <name>Q1D528_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554074.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4067"/>
    <dbReference type="EnsemblBacteria" id="ABF90769">
        <property type="protein sequence ID" value="ABF90769"/>
        <property type="gene ID" value="MXAN_4067"/>
    </dbReference>
    <dbReference type="GeneID" id="41361397"/>
    <dbReference type="KEGG" id="mxa:MXAN_4067"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_0_7"/>
    <dbReference type="OMA" id="CPGIKAR"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="90" mass="9586" checksum="73D92A7AB0289081" modified="2006-07-11" version="1">MATLRIPTPMRGFTGNQAEVAAPGATVGEVLKNLDARHPGIGGRVFDERGAVRRYVNVFLNDEDIRALNGLDTPVKDADRITLIPAMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D542</accession>
    <name>Q1D542_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554060.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D542">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4053"/>
    <dbReference type="EnsemblBacteria" id="ABF90932">
        <property type="protein sequence ID" value="ABF90932"/>
        <property type="gene ID" value="MXAN_4053"/>
    </dbReference>
    <dbReference type="GeneID" id="41361383"/>
    <dbReference type="KEGG" id="mxa:MXAN_4053"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_34_0_7"/>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="PubMed" id="17015832"/>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
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                <person name="Hinkle G."/>
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            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88347.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DK1622</strain>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="24501" checksum="D92F02ACD00B53E5" modified="2006-07-11" version="1">MDLRADGLTVRYGARQVLSGVSCALPPGTQALVLGRSGAGKTTLVKALAGLVRPTEGRVLWDGQDAARLTAAERREQQASFGMVFQTDALFDSMTVLENVMAPLTRRHVPEAEARARASDVLRAVGLADAAGTLPERLSGGMKKRAGIARALAARPSVVLADDPFAGLDPGTARQVARVLLDVSQGGTLLVVATEAPMDLPLPRWLYLRSGRLVHDGPPAPEWEDAPDEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Y1</accession>
    <name>Q1D5Y1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acdA</name>
        <name evidence="9" type="ORF">MXAN_3760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553773.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3760"/>
    <dbReference type="EnsemblBacteria" id="ABF87051">
        <property type="protein sequence ID" value="ABF87051"/>
        <property type="gene ID" value="MXAN_3760"/>
    </dbReference>
    <dbReference type="GeneID" id="41361092"/>
    <dbReference type="KEGG" id="mxa:MXAN_3760"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="EWDETHH"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="41580" checksum="F34FE5EAC70BD2C3" modified="2006-07-11" version="1">MDFDLPESHRALQSSIRDFCERRVKPYAREWDKDETFPMEVVRELGQLGVMGMLVAEEFGGAAMDSLAVAVAVEEIARYDGSLALTVASHNGLGTSHLRVFGSDAQRQKYLPKLATGEYLGAWGLTEPGSGSDASSMKTTAMRKGDGWVLNGAKMFITQGTVGDVFVVLAVTSPQKRQKGITAFLLEKGLPGFSQRAIHGKLGMRSSDTAELVLENVEVPDSARVGELDHGFIDTMKILDRGRITIGALAVGLGRGALEESIGYSRERTAFGQPISEFQGLRWMMADMKTELDAARLLVHRAAKLADEGKPYSREASMGKLFASEAAMRACNKAVQIHGGYGYTREFPVERYLRDAKLCEIGEGTSEIQRTIIARETFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z6</accession>
    <name>Q1D5Z6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553758.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3745"/>
    <dbReference type="EnsemblBacteria" id="ABF86576">
        <property type="protein sequence ID" value="ABF86576"/>
        <property type="gene ID" value="MXAN_3745"/>
    </dbReference>
    <dbReference type="GeneID" id="41361078"/>
    <dbReference type="KEGG" id="mxa:MXAN_3745"/>
    <dbReference type="eggNOG" id="COG2854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094502_2_0_7"/>
    <dbReference type="OMA" id="MMGAWLI"/>
    <dbReference type="OrthoDB" id="1716096at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008869">
        <property type="entry name" value="MlaC/ttg2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042245">
        <property type="entry name" value="Tgt2/MlaC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36573">
        <property type="entry name" value="PTHR36573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05494">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="21384" checksum="8C21D0558013E291" modified="2006-07-11" version="1">MIASLLAATLLAAAPGPLTVVQSGNADVQKAANAPGATAQSLATVVEKFVDFEELAKRALGDKTWAGLQPAQRKEFTETMTGLLRASYAQKALGQAQAQVKYGEEGIDGNEASVGTTVTVKKDAIPVEYRLYRTSATGAWRIYDVITDEVSLVDTYKGQFRKLLADKGFDGLLSTLKSKRTQLEKENATSAQKSAGQTAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6E7</accession>
    <name>Q1D6E7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553612.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3586"/>
    <dbReference type="EnsemblBacteria" id="ABF88427">
        <property type="protein sequence ID" value="ABF88427"/>
        <property type="gene ID" value="MXAN_3586"/>
    </dbReference>
    <dbReference type="GeneID" id="41360932"/>
    <dbReference type="KEGG" id="mxa:MXAN_3586"/>
    <dbReference type="eggNOG" id="COG3018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060107_0_0_7"/>
    <dbReference type="OMA" id="VNWEGQV"/>
    <dbReference type="OrthoDB" id="1324896at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="31566" checksum="FE4BD2D852C0E518" modified="2006-07-11" version="1">MPQGPALTSPEAGPLNGKPFCPDTTRDVGRGAGGFPVRHSLWGILLAVPLTAFGQGKEAKAPKPTVAAEKTAPGAPGVNWEGQVLRATGVGAPDLKASNPGQARLGAERIAKRSAVQNLMDQAGRLHISAGRTVADELARDDVRKRVEAAMGGYKVVARRFFSDSGVEIDVEVPLSALTASLFAPPAADTVIAINGAGAKKYTGLVVDARGLGVQPVLAPRLLDDSGKALYGAAALASERRAATAVAAWFQSLDAAKKASLVGDKPLVVKAKGSKGSDLVLASEDAKALVEANTRFLAEGRVVIVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6K9</accession>
    <name>Q1D6K9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3520"/>
    <dbReference type="EnsemblBacteria" id="ABF86828">
        <property type="protein sequence ID" value="ABF86828"/>
        <property type="gene ID" value="MXAN_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3520"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_7"/>
    <dbReference type="OMA" id="CPDIIPV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="430" mass="45444" checksum="D041057C09B060D9" modified="2006-07-11" version="1">MSTAKASRIVVDPSALHAAPLTPPVSKSDAQRALVLGHLTGSWPLPSVQAEADEDLPADVRVLRQGVEALRLPPDAVRDIDCADGGAPFRILATQAAVTPGAQARFTGTPRLGERPHGPLFTSLREALGPMGLTLTEGTPWPVELRAPRDTSNATPVFRVPGAQSSQYASSLLLGCAALYLRERRPWRVEIDGPLTSAGYLELTLTWLSRFGFDILRSPSSYTVAGYAAPPAVPTLPGDWSSLGYLLLVAWKTGGTVVRADTGSAHPDDAIVRLIEQVGLRAVPAGPPFTLKVEGQLSGGLRASGEECPDLLPTLAALACVLPAPSTLTEVGILRVKESDRLEGIRTLVKAFGGTTELQGEQLLIQPPRTPPAGFEMSSEGDHRLAMTAATLCVLSGTPLTLTGPECVEKSFPGFWRQLSRVGVRITDAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L9</accession>
    <name>PYRB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="1">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate transcarbamylase</fullName>
            <shortName evidence="1">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrB</name>
        <name type="ordered locus">MXAN_3510</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553540.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6L9"/>
    <dbReference type="SMR" id="Q1D6L9"/>
    <dbReference type="STRING" id="246197.MXAN_3510"/>
    <dbReference type="EnsemblBacteria" id="ABF90384">
        <property type="protein sequence ID" value="ABF90384"/>
        <property type="gene ID" value="MXAN_3510"/>
    </dbReference>
    <dbReference type="GeneID" id="41360855"/>
    <dbReference type="KEGG" id="mxa:MXAN_3510"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_7"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000301595" description="Aspartate carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <sequence length="297" mass="31933" checksum="32AFB1AEF9087707" modified="2006-07-11" version="1">MRHLLGIEGWRRDELESLLDRAKAHLPGGPDTTHLLRGKVVANLFFEDSTRTRTSFHMAAKGLGASVLNWTHTGSSVSKGETLLDTARNIEATGPVAIVMRHRSSGAPHLVAKHVKCAVINAGDGTHEHPSQALLDAFTLRQRWGSLDGRTVLIVGDVLHSRVARSNLHCLKALGAQVVMCGPPTLLPPGLESLGAEVTHNLDAALPRADAVMCLRVQLERQEQAFLPSTREYARLFGLNAAREERMKAGAVVMHPGPINRGVELAPAVADGARSVILEQVSNGVAVRRAILEVCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6W6</accession>
    <name>Q1D6W6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="10">DHBP synthase</shortName>
            <ecNumber evidence="6 10">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="10" type="synonym">ribB</name>
        <name evidence="13" type="ORF">MXAN_3410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3410"/>
    <dbReference type="EnsemblBacteria" id="ABF88643">
        <property type="protein sequence ID" value="ABF88643"/>
        <property type="gene ID" value="MXAN_3410"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3410"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_7"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="12">
        <location>
            <begin position="216"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="10">
        <location>
            <begin position="31"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="10">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="373" mass="41125" checksum="5340B7BB5BDBBE81" modified="2006-07-11" version="1">MSHDSEISSIDDAIRDIQEGKFVIVADDEDRENEGDLIMAAEKVTPEHLAFMVRHTSGIVCMPMLAERLDELRLPQMVSDNTESHRTAFTVSVDYRHDTHTGVSAADRAKTIRALVDPSSKADDFLRPGHIFPLRYREGGVLRRAGHTEATVDLSRLAGLSASGILCELVKDDGTMMRMPDLKVFAREHKLSLITIADLIEYRRRKDRLVRREPGQQTVNTRYGEFTALTYSWLPDGVKSLVLVKGDPASRPSTLVRLHAACALGDVFGSPSCNCNVLLDQALARIAREGSGVLVYLPGMHGDDFGIHHKRNNDGSSGPTRGPQESRDLGMGCQILTDLGIHTLQVMTNSDVTYRGLAGFGLTIEKRVPLQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E6</accession>
    <name>Q1D7E6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3228"/>
    <dbReference type="EnsemblBacteria" id="ABF87335">
        <property type="protein sequence ID" value="ABF87335"/>
        <property type="gene ID" value="MXAN_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3228"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052027_2_3_7"/>
    <dbReference type="OMA" id="NPVSEQF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="6">
        <location>
            <begin position="45"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="24740" checksum="37EFC62AD11AE1F6" modified="2006-07-11" version="1">MDDNPTGGNAVDRRVVTLTAPASAAAEQYRSLYYRLERMRDLRPMKVVALTSAMPGEGKTVTSVNLALAAARANPERRILLVDADLRRGGVAAMLGMRNKMGLAELLAGDCEVRDVVRRFNSTRLALIPAGVTPEDTAQVLASGRMKQFLKAVREGFDEVYVDLPPALPFADAAILGHQADGMLMVIRANVTSGKAVHLAVESLGGAPIIGCVLNGAEVHSAPYLKNYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F3</accession>
    <name>Q1D7F3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.51</ecNumber>
            <ecNumber evidence="7">5.4.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">pheA</name>
        <name evidence="24" type="ORF">MXAN_3221</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="8"/>
    <dbReference type="EC" id="5.4.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553266.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3221"/>
    <dbReference type="EnsemblBacteria" id="ABF89557">
        <property type="protein sequence ID" value="ABF89557"/>
        <property type="gene ID" value="MXAN_3221"/>
    </dbReference>
    <dbReference type="GeneID" id="41360575"/>
    <dbReference type="KEGG" id="mxa:MXAN_3221"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_1_1_7"/>
    <dbReference type="OMA" id="HTRFVIL"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
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    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
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    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 24" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="22">
        <location>
            <begin position="101"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="23">
        <location>
            <begin position="295"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="20">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ABF89557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="41778" checksum="9AA688AEFBE26DCC" modified="2006-07-11" version="1">MTTLPDLDLIRTSIERIDEEILDALRRRMALADDVARAKLAAAAPFRDQRREDLLLRRIRTRAAEHGLDPHEVERIWRLFIDMSVARQHELVTRLDTTPLRVAYPGVEGSYSHLAARRRYGHRAGGVLLSGFDHAREAVEALRRGEQDLVLLPIENTTAGSMNETYDLLAEGGVVITAELVSQVDHRLLGLPGAKLEGLREVLSHPQALAQCETFLREKVPWARAVPDVDTGGAAQKVRERNDASVAAIASETAAQRFGLEVLAGDLQPAFDYTRFVEVGREASPLAPGVPCKTSLLVVLEHKPGTLGEMLQRLTLRGVNLSKLESRPIPGQPWQYRFYLDVEGHAASAAVTAALDDIRPLTSSLRVLGTYARAESPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7F6</accession>
    <name>Q1D7F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553263.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3218"/>
    <dbReference type="EnsemblBacteria" id="ABF90636">
        <property type="protein sequence ID" value="ABF90636"/>
        <property type="gene ID" value="MXAN_3218"/>
    </dbReference>
    <dbReference type="GeneID" id="41360572"/>
    <dbReference type="KEGG" id="mxa:MXAN_3218"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433107_0_0_7"/>
    <dbReference type="OMA" id="SMAGNHE"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20493" checksum="C0640DA3A681E683" modified="2006-07-11" version="1">MSKLLFAAFNDGVSLSMAGNHEAAILAFDKVLAVDPKHVPALTAKGASLATLERFEEALRCFERAIEVDPTEAEAHRDAALCQLELGEPEAAAQLLQRATQLNPTPGYRESAAVQIYTLGNALLTRGSRRPDKARYRQARHVFELALTLSPGSAECARALADVWEHLGDPVQRDHYAQLATRLRPVPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U5</accession>
    <name>RL10_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">MXAN_3075</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553125.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7U5"/>
    <dbReference type="SMR" id="Q1D7U5"/>
    <dbReference type="STRING" id="246197.MXAN_3075"/>
    <dbReference type="EnsemblBacteria" id="ABF91324">
        <property type="protein sequence ID" value="ABF91324"/>
        <property type="gene ID" value="MXAN_3075"/>
    </dbReference>
    <dbReference type="GeneID" id="41360437"/>
    <dbReference type="KEGG" id="mxa:MXAN_3075"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_2_1_7"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000005542" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <sequence length="173" mass="18700" checksum="74A9B770EB18B11E" modified="2006-07-11" version="1">MLKSEKEEMIKELHEKFSRTTSAVVAEFTKVDVETVTKLRKKFREGNVEYKVIKNTLARRAAQGTSVSVIADDFTGPVALCISYGDVVAPAKILVEFAKDIEDKIKIRTAVVEGRKVDVAGVKALAKLPGLPELRAQLLGVISEPASKLVRTIAAPGSQLARVVQANADKAQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U7</accession>
    <name>RL11_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">MXAN_3073</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553123.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7U7"/>
    <dbReference type="SMR" id="Q1D7U7"/>
    <dbReference type="STRING" id="246197.MXAN_3073"/>
    <dbReference type="EnsemblBacteria" id="ABF86547">
        <property type="protein sequence ID" value="ABF86547"/>
        <property type="gene ID" value="MXAN_3073"/>
    </dbReference>
    <dbReference type="GeneID" id="41360435"/>
    <dbReference type="KEGG" id="mxa:MXAN_3073"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_0_7"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000258173" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="148" mass="15581" checksum="44CF098AD5C9E133" modified="2006-07-11" version="1">MKKITGQVKLQIPAGKANPAPPIGPALGQQGVNIMEFCKQFNAKTQAEAKEALIIPVVITVYADRSFTFILKTPPAAVLIKKAAGLHTEKKKGSGAKKPGKEKVGQITRAQLEEIAKKKIQDTTAASLEACMSTIAGTARSMGIDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W1</accession>
    <name>Q1D7W1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553109.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3054"/>
    <dbReference type="EnsemblBacteria" id="ABF88405">
        <property type="protein sequence ID" value="ABF88405"/>
        <property type="gene ID" value="MXAN_3054"/>
    </dbReference>
    <dbReference type="GeneID" id="41360416"/>
    <dbReference type="KEGG" id="mxa:MXAN_3054"/>
    <dbReference type="eggNOG" id="COG2153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_6_1_7"/>
    <dbReference type="OMA" id="HRNRNVY"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17444" checksum="4DD0B1C4F2A6E8EC" modified="2006-07-11" version="1">MASPTDTSAPVTITQIQSEAELMQALAIREVVFIEEQAVPEGIERDAEDAHAYHVIANQGGHAIGTGRLVMLTQPPANQEGTWGQIGRMAVLQAHRKARVGSMLLTSLEEEARRRGVNGIMLHAQLYALEFYKKHGYLPVGGVFEEAGMEHLEMHKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W2</accession>
    <name>Q1D7W2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553108.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3053"/>
    <dbReference type="EnsemblBacteria" id="ABF92669">
        <property type="protein sequence ID" value="ABF92669"/>
        <property type="gene ID" value="MXAN_3053"/>
    </dbReference>
    <dbReference type="GeneID" id="41360415"/>
    <dbReference type="KEGG" id="mxa:MXAN_3053"/>
    <dbReference type="HOGENOM" id="CLU_725271_0_0_7"/>
    <dbReference type="OMA" id="HKRDENF"/>
    <dbReference type="OrthoDB" id="1149579at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="42462" checksum="4B8BE5CD5F2618C2" modified="2006-07-11" version="1">MARRGLRPVPRPPAVTGGPHGGSVRRARLQGAMRFNRLLALALALSAMPATAQPELFFGNGQAPVFREEDLDKRFARSKLNQGLKQGTQDAGCAQVLGAMLTLMGETGVLLHKRDENFMLDPVLVNALNTQLVNQRFPGNAFLVAMVRRVLIDRKLPQEWLVTAQALAPYYPAIDMGRLRFLANGVQPLDSFLVTLPALRERYAQEVQRATSVGASTAEALFRENYLDHEVAFGALELVDVKLEKPKKKRLKKDEEPEAPYMLARLLWVEPEAPTTERFEFNFGKAPKRPRVEITAKLQDTQYTDLNKLLKGSRVLVRGRFWEYKKGLTSIELRDALIFPERDWTKTPSLADPAAVASCPLAVNDLTGLAPMQPGAFGTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8A4</accession>
    <name>Q1D8A4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2908"/>
    <dbReference type="EnsemblBacteria" id="ABF87469">
        <property type="protein sequence ID" value="ABF87469"/>
        <property type="gene ID" value="MXAN_2908"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2908"/>
    <dbReference type="eggNOG" id="COG3121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299319_0_0_7"/>
    <dbReference type="OMA" id="GCADRER"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
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            <end position="139"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1005" mass="107267" checksum="690624D68B7089B3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8F5</accession>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2857"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="607"/>
        </location>
    </feature>
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        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121298" checksum="97027CE9D9F97364" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92800">
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2839"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="200" mass="23086" checksum="8DB1BCDFAA073835" modified="2006-07-11" version="1">MKPTYTVAAVRNQDELEHILALQQKNLKQALSADEMRSQGFVTVQHDLPALEQMHAMAPSIVARHDGVLVAYALTMPREARALAPVLEPMFALLDSLEFRSKSLRDYRFYVMGQICIDKAHRGQGLFDRLYHQHRDHFRDQFDLIVTEISVRNLRSLRAHERVGFETIHTYRDATDEWAVVAWDWAPPRPPDVTPEGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I1</accession>
    <name>Q1D8I1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2831"/>
    <dbReference type="EnsemblBacteria" id="ABF88082">
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        <property type="gene ID" value="MXAN_2831"/>
    </dbReference>
    <dbReference type="GeneID" id="41360202"/>
    <dbReference type="KEGG" id="mxa:MXAN_2831"/>
    <dbReference type="eggNOG" id="COG0715">
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    <dbReference type="HOGENOM" id="CLU_028871_1_4_7"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187984" evidence="2">
        <location>
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            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="264"/>
        </location>
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        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="36985" checksum="EC7D6BDE676D9490" modified="2006-07-11" version="1">MSGRLLKLLGCAVLLVAAGACSRQKEEPKQGSQAATGASTAPPKADAPAKVRLALNWVPEPEFGGFYAARESGAFSRHGLEAEILGGGAGAPVPQMVATGKVEFGISGADELLVARARGLDVIPLFAVYQTSPHAIMAHASRGAKNIADVLSSGTVALEPGLSYVAFLKKKYSFDKVKVVPYDGGVARFLADKDFAQQCFVTAEPIAAKRQGATPTVFLVAEEGFNPYLAVVITRRQYWKEQPERVKSFVAAVREGWRTYLDNPGPTNAVMGKLNTTMDAETFAEGAETQKPLIETEETRARGLGTMNRQRWEQLAQQLVELDLIEKAPAADEFLLPEFTGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8L7</accession>
    <name>Q1D8L7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552856.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91754">
        <property type="protein sequence ID" value="ABF91754"/>
        <property type="gene ID" value="MXAN_2789"/>
    </dbReference>
    <dbReference type="GeneID" id="41360165"/>
    <dbReference type="KEGG" id="mxa:MXAN_2789"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_7"/>
    <dbReference type="OMA" id="AIHISIA"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="470" mass="50355" checksum="8C9A710774BE1C04" modified="2006-07-11" version="1">MEVAASPNADPHGAPSLGLFRLTWPIFLELLLFMMMGTADTLMLSGVSDDAVASVGVVNQYVFICILIMEVVGHGAAIVVAQYLGARRQTEAARISAIAVTLNLALGITVSAGLLLSGDAILGGMNLQGHMLAYAKTYLHIVGGFLFIQALINVFAGLLRTYGFTRASMFVSLGMNVLHVGGNYVLIAGHFGFPAMGVAGAAISTVVSRAIALGVFVYVLYRVMPVKMAPRDYVTFSKDYVRKILKVGLPSAFEQATYQGCQTVFLYYVTFLGAVALASRQYAHAISQYVFLCSLAIGMGTSIIVGRLVGANRADDAYQQALRSLKWGLAITLVVDVAVVLLRVPIVSLFTENADIVRLTAQVIVIGLALETGRCFNLVLINALRAAGDATFTVYMGIASMVCMSLPLGYYLVFHMGLGLAGVWMAVAADEWVRGITMWLRWKSRAWEKQVLVSLDAETEAEAAPVAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8N4</accession>
    <name>Q1D8N4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein, GvpL/GvpF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2772"/>
    <dbReference type="EnsemblBacteria" id="ABF86763">
        <property type="protein sequence ID" value="ABF86763"/>
        <property type="gene ID" value="MXAN_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2772"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065736_0_0_7"/>
    <dbReference type="OMA" id="WAPYSFT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="31178" checksum="55A5E88F29A496F9" modified="2006-07-11" version="1">MRAHSNPGVQGRRKGQQALYVYGFTRAGAVEHFSVPGISGAADVRALKLGNLAAIYSPLSMEEFLGPEGADHTQDLEWVAPRAVRHEGVLEEVMQSSPVLPVSFGAIFSSPRALSKAVDAHRQEISSFLDDIADKEEWAVKVYANAQRLRAHLERAPEFRQRLQHLPESPGARYFHEKKMQRELDVRSRNEGQSLAAHIREELAPAALSVKPLRLADRGISGRQDDMVLNSAFLVHSGQVQRFAQRVQQLAARYQPQGLTVETTGPWPPYSFCPSLEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D918</accession>
    <name>Q1D918_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552706.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2636"/>
    <dbReference type="EnsemblBacteria" id="ABF86695">
        <property type="protein sequence ID" value="ABF86695"/>
        <property type="gene ID" value="MXAN_2636"/>
    </dbReference>
    <dbReference type="GeneID" id="41360012"/>
    <dbReference type="KEGG" id="mxa:MXAN_2636"/>
    <dbReference type="eggNOG" id="ENOG5030VGG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2092673_0_0_7"/>
    <dbReference type="OMA" id="CSVEAMP"/>
    <dbReference type="OrthoDB" id="1957207at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="14288" checksum="A87460A6CC2842F8" modified="2006-07-11" version="1">MLPACSVEAMPPPALTLVAPTPSRRADPVRVAVEQLARSLPARTDAAVLLDLLEDDLREGLDALGEVEAHFTDLLDTLRTEAVTPAALVESGDDLRVLQQLDSLHDAVVRLRKRLSQAASMNRLAHAPVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Z8</accession>
    <name>Q1D9Z8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TonB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2305"/>
    <dbReference type="EnsemblBacteria" id="ABF89215">
        <property type="protein sequence ID" value="ABF89215"/>
        <property type="gene ID" value="MXAN_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2305"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133217_0_0_7"/>
    <dbReference type="OMA" id="AHFHVAW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="171" mass="18235" checksum="F0E31B0D643F4672" modified="2006-07-11" version="1">MFIPGGERIRARLRPVGGRTLADYHWPFLDEGTFLETLFRNGRLALAAVLVLALSPMALAAAGSPQLQAFFQQDLTSADYQQKVYSRVAGKWRQPGAKGTPGLGKKTVVRAVIGRDGKLLSADVSTESGSKTWDAAALLAVKKAAPFPPLPANFPGATLDAHFHVAWVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA94</accession>
    <name>Q1DA94_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2207"/>
    <dbReference type="EnsemblBacteria" id="ABF90855">
        <property type="protein sequence ID" value="ABF90855"/>
        <property type="gene ID" value="MXAN_2207"/>
    </dbReference>
    <dbReference type="GeneID" id="41359596"/>
    <dbReference type="KEGG" id="mxa:MXAN_2207"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_2_0_7"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="OrthoDB" id="1691691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="22333" checksum="CAA992F6FA501631" modified="2006-07-11" version="1">MSVYPSGAPCPRGVRFWRLRLTLAATARHCPRVLADALARSRAHDVALVLGGALLTAGLAQVSISVPGSPVPITGQSLGVIVAAAALGPVRGMAAQFLYLLMGAVGLPFFAEGASGLERILGATGGYLVGFVPAAFLVGLAAQRGFDRRPWTALPLFAVGQLAVFAVGLPWLVLSARLGVAKALGVGFTPFLPGGLLKAAIAAVLLPLAWRLVGPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG6</accession>
    <name>Q1DAG6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2133"/>
    <dbReference type="EnsemblBacteria" id="ABF87780">
        <property type="protein sequence ID" value="ABF87780"/>
        <property type="gene ID" value="MXAN_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2133"/>
    <dbReference type="HOGENOM" id="CLU_3357238_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="36" mass="3720" checksum="068F13E06DC07ED4" modified="2006-07-11" version="1">MLVGAPAHGHILPEPSVTCLRDADIRQPLAQLAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAH2</accession>
    <name>Q1DAH2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, M12A (Astacin) subfamily</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2127"/>
    <dbReference type="EnsemblBacteria" id="ABF88631">
        <property type="protein sequence ID" value="ABF88631"/>
        <property type="gene ID" value="MXAN_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2127"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_615123_0_0_7"/>
    <dbReference type="OMA" id="ETFRIWK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="136"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="474" mass="51266" checksum="15DDE212D40F6EC8" modified="2006-07-11" version="1">MAEVCPESSQQNQTPSDIRRPEILTRSGEIMSRDLSRLALSALFIPSLLLIACGEENLAPGLNLDPEMARVPAGAPIREGYIWSNMREKFVPVTYAEVDGLAIQEGDMVLGTVQQMEARVREVKALGLDASGPRAQGLAKTDLNSRWPNAVVPYTIDSGVANQNRIQDAINHWHDRTHISFVLRTANNAAQYPDYVRIQSGTGCSAHYGRLGGQQGVWLDGSCSTGTIIHELGHSLGLNHEHNRQDRDTYVIIRWENMVAGAASQFQQNNNEDDDFFGYDFGSIMHYGPMQGSKNGRPTIEGRGGQTIGQRNALSTLDVVTVTRLYSRTITLRASNGDYLVAEGGGGAMVDANRVAVGPWERFQLVDLDGNDLVTGDLVQLQTINGNFVQATNGGGSTLNAWEMAPGNWETFRIWKMAGTGLSTIATGDGVVLGTLTPGYPKYWQAVNGGGAGVTVNTDTINLGPANIFTVAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAI4</accession>
    <name>Q1DAI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552194.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91750">
        <property type="protein sequence ID" value="ABF91750"/>
        <property type="gene ID" value="MXAN_2112"/>
    </dbReference>
    <dbReference type="GeneID" id="41359517"/>
    <dbReference type="KEGG" id="mxa:MXAN_2112"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279897_0_0_7"/>
    <dbReference type="OMA" id="WASETNE"/>
    <dbReference type="OrthoDB" id="2115871at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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</entry>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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            <strain evidence="2">DK1622</strain>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="642" mass="68193" checksum="FB416AEC13399806" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBW4</accession>
    <name>Q1DBW4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
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        <name evidence="6" type="ORF">MXAN_1607</name>
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    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
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        <property type="match status" value="5"/>
    </dbReference>
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    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2029"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3074"/>
            <end position="3149"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="4129"/>
            <end position="4204"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="5196"/>
            <end position="5271"/>
        </location>
    </feature>
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        <location>
            <position position="1004"/>
        </location>
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    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2064"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3109"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4164"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="5544" mass="600557" checksum="E2B09912F587F756" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC00</accession>
    <name>Q1DC00_MYXXD</name>
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        <recommendedName>
            <fullName evidence="5 10">Cysteine synthase</fullName>
            <ecNumber evidence="5 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="12" type="ORF">MXAN_1571</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
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    </comment>
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    <dbReference type="EMBL" id="CP000113">
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_1571"/>
    <dbReference type="eggNOG" id="COG0031">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="33343" checksum="82258863E344E085" modified="2006-07-11" version="1">MKVNNILETIGNTPHVRINRLFPSRVTVHMKLERANPGGSIKDRIALSMIEDAEQRGLLKKDSVIIEPTSGNTGIGLAMVAAVKGYKLVLVMPESMSVERRRLMAAYGATFELTPRAQGMKGAIARANELLSQVPNSWMPQQFENEANIEVHRRTTVQEILKDFPEGLDYLITGVGTGGHITACAEELKKVWPKLKVFAVEPTKSPVISGGQPGPHPIQGIGAGFIPKNLHKDALDGAIQVTEEDAFEFTRRAAREEGIFVGISTGAALSAVNQKLGEMTDGSRVLAFNYDTGERYLSIEPLFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC38</accession>
    <name>Q1DC38_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltooligosyltrehalose synthase</fullName>
            <ecNumber evidence="3">5.4.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">treY</name>
        <name evidence="3" type="ORF">MXAN_1533</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.15" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1533"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86306">
        <property type="protein sequence ID" value="ABF86306"/>
        <property type="gene ID" value="MXAN_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1533"/>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005045_1_0_7"/>
    <dbReference type="OMA" id="WTVVEKI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047470">
        <property type="term" value="F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="35"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1013" mass="115086" checksum="21004865A9843507" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC9</accession>
    <name>Q1DCC9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ORF">MXAN_1437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1437"/>
    <dbReference type="EnsemblBacteria" id="ABF92213">
        <property type="protein sequence ID" value="ABF92213"/>
        <property type="gene ID" value="MXAN_1437"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1437"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_2_0_7"/>
    <dbReference type="OMA" id="IFFDFFD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="30268" checksum="D12D2FAD55B3CD65" modified="2006-07-11" version="1">MKLRKLMFVLPNLFTVTSIFCGFYAITLCTGDAEPVQLYQAALAIFFAMFFDGFDGRVARLTKTQSDFGVQLDSLADVISFGAAPSLLVYKWALEPLGFMGLFIAFSFAACGALRLARFNVLAARNPHGGGGSFFVGLPIPVAAGMLVSVIISHHAATQGQPLAESAVVPMAVAVAGLALLMVSTVRYRTFKDTRPNRKSALAFMLVVVGGTVIATQLHPAWVLVACCGAYLALGLVESAVLVRSRLVARKGAAPCAVAAVAVATVIDDEEEEDAESNQGNDGPAYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD74</accession>
    <name>PRMA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="1">L11 Mtase</shortName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmA</name>
        <name type="ordered locus">MXAN_1139</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551259.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DD74"/>
    <dbReference type="SMR" id="Q1DD74"/>
    <dbReference type="STRING" id="246197.MXAN_1139"/>
    <dbReference type="EnsemblBacteria" id="ABF91234">
        <property type="protein sequence ID" value="ABF91234"/>
        <property type="gene ID" value="MXAN_1139"/>
    </dbReference>
    <dbReference type="GeneID" id="41358590"/>
    <dbReference type="KEGG" id="mxa:MXAN_1139"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_1_7"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000072793" description="Ribosomal protein L11 methyltransferase">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <sequence length="288" mass="30747" checksum="108EC675E82C0A02" modified="2006-07-11" version="1">MSQTYLSLTVELPEEASEAVQDLLHESGALGLEVRDREAPLMPGVRGPNPGEAIIIGYFDERDTAESARDEVASSFPEAKLTLDEQPQQDWSNEWKSLIKSVHVGRLWVGPPWDKANAPAGTVQLVIEPKMAFGTGDHPTTSLCLAAVDAYMAEHPGAAVLDVGTGTGVLAIAAKKLGAGRTVATDNDPISVELAQENQAENGTPDIEVSGKELTQVEGTFDLVLANILANTLIELAPLIVAKTKDRLVLAGVLSHQRADVEAAYRNLGLTVLTGATQGEWVRIDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDD5</accession>
    <name>Q1DDD5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding response regulator Nla19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nla19</name>
        <name evidence="9" type="ORF">MXAN_1078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="MXAN_1078"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0043565">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
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    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHFIS"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="151"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="482" mass="53192" checksum="FDD1C56FC51B42F0" modified="2006-07-11" version="1">MTDANTPPTRGRLLVVDDQRNMRATTALLLRAENYTVFEAATGEEALAQLASGSIDLLLTDLKMEPMDGLTLLRRALEVAPRLQVIMMTAFGSIESAVEAMRLGAYDYVTKPFKESELRYRVERALERARLQRDVDNLTTDFNQRHGLSALVGRSAAMRELTTRLMRVAQSDATVLIQGESGTGKELVARALHAHSRRKARSFVPVNCAAISESLLESELFGHAKGAFTGAVKSRRGLFEEADGGTLFIDEVTETSPTFQSKLLRALQEGEVRRVGESTALRVDVRIVAATNRDIELEVRDKRFRQDLYYRLNVVALRVPPLRERLEDVPALAEHFLERANARSPNPKRLSAAAVSHLMSYGFPGNVRELENLVEQAAALAEGDELLPEDFPVRQGRMTPAHGTPSVAFLDGQGGALGRNASAGPTLAQVVEEAERHAITQALERHGVDLARVADELGVSSTTLWRKMKRLNLRPPSELARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS3</accession>
    <name>Q1DDS3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551060.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0939"/>
    <dbReference type="EnsemblBacteria" id="ABF91536">
        <property type="protein sequence ID" value="ABF91536"/>
        <property type="gene ID" value="MXAN_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="41358398"/>
    <dbReference type="KEGG" id="mxa:MXAN_0939"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010457_3_0_7"/>
    <dbReference type="OMA" id="APGQEFK"/>
    <dbReference type="OrthoDB" id="1706506at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02231">
        <property type="entry name" value="TIGR02231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="2">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="1">
        <location>
            <begin position="208"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="521" mass="57900" checksum="505D35FEB6765B27" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE95</accession>
    <name>Q1DE95_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550888.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90984">
        <property type="protein sequence ID" value="ABF90984"/>
        <property type="gene ID" value="MXAN_0762"/>
    </dbReference>
    <dbReference type="GeneID" id="41358231"/>
    <dbReference type="KEGG" id="mxa:MXAN_0762"/>
    <dbReference type="HOGENOM" id="CLU_2287252_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="95" mass="11121" checksum="4BE7FC7130B8E9BB" modified="2006-07-11" version="1">MKEPFWTLYLTLTVHGHPPDIWYYNVKLRNEAIYIGTNEHHITVLANHGGWHVTINQSHDGQVAGGFDDLVNLRWDVTPEIGRALEWIRHHRVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA8</accession>
    <name>Q1DEA8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0749"/>
    <dbReference type="EnsemblBacteria" id="ABF91453">
        <property type="protein sequence ID" value="ABF91453"/>
        <property type="gene ID" value="MXAN_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0749"/>
    <dbReference type="HOGENOM" id="CLU_1775453_0_0_7"/>
    <dbReference type="OMA" id="TIEDHRP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="20024" checksum="039BC7A7777DF269" modified="2006-07-11" version="1">MPCRLPCHRAFAAPGPVPLPTFNPADRFRGAMETNNEKEALFNPGCEPVVEDEERRRLLWLMAEYFRTIGYTDIKARLPGFMPPPILSGTIEDHRPDFTCRQSDSARTPIILEIVTPHMVDEPTAENRWSLLASAAKLYNAELHFVVPKWAATGAVDPGLKRRLARMELTANRVWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEM1</accession>
    <name>Q1DEM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550765.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0634"/>
    <dbReference type="EnsemblBacteria" id="ABF87394">
        <property type="protein sequence ID" value="ABF87394"/>
        <property type="gene ID" value="MXAN_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="41358112"/>
    <dbReference type="KEGG" id="mxa:MXAN_0634"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383018_0_0_7"/>
    <dbReference type="OMA" id="IVFFECR"/>
    <dbReference type="OrthoDB" id="1049307at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="700" mass="72941" checksum="05309A4DE03BF342" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEN8</accession>
    <name>Q1DEN8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550748.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0617"/>
    <dbReference type="EnsemblBacteria" id="ABF87641">
        <property type="protein sequence ID" value="ABF87641"/>
        <property type="gene ID" value="MXAN_0617"/>
    </dbReference>
    <dbReference type="GeneID" id="41358095"/>
    <dbReference type="KEGG" id="mxa:MXAN_0617"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_4_2_7"/>
    <dbReference type="OMA" id="GHEGCGA"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="22922" checksum="87AA3C85462628A7" modified="2006-07-11" version="1">MPTASTPPISAQDALARLREGNQRFVLNARNMENPLGRSARQALVAGQSPFAIILSCSDSRAPSEYIFDQGLGDLFVIRVAGNVVAPSLVGSVEFAAAKFGTRLAVVMGHSHCGAIQATLDYLRDGKSEASENIRDIVERCREPVATVVSAAGPKADPEFLMKESVRANIRNSCDNLRHGSRLLERLCREEGMLIVGAEYSLETGAVDFFNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF17</accession>
    <name>Q1DF17_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550619.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89882">
        <property type="protein sequence ID" value="ABF89882"/>
        <property type="gene ID" value="MXAN_0486"/>
    </dbReference>
    <dbReference type="GeneID" id="41357978"/>
    <dbReference type="KEGG" id="mxa:MXAN_0486"/>
    <dbReference type="HOGENOM" id="CLU_1141063_0_0_7"/>
    <dbReference type="OMA" id="KVWANRI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="276" mass="31905" checksum="6C8E6A6E2BD516D0" modified="2006-07-11" version="1">MGLGPPSLHTRRAQRAAAYSRINVILYIRTRGWRHSKTMTFSETWDLAWSILLSIGSAGGLILGLSNWLGKVWANRILEREKLAIQRELQALQAESAQRLHALKERTDVLLKNLEAEHSRRHRVHNLQFAKEFQLYADTWKALHALKIKTLTLRPVGDVVDVRETEEERRERRYKEFAEAFNAAVSVIAENEPFFPQEVFAKIRELQSLSRREAFSYYYKGRQKKGVDMKYWEEAEENQQQIVEQVDAICEAIRTRIGLIEIVEGPQGVAPSVPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF38</accession>
    <name>Q1DF38_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0465"/>
    <dbReference type="EnsemblBacteria" id="ABF87222">
        <property type="protein sequence ID" value="ABF87222"/>
        <property type="gene ID" value="MXAN_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0465"/>
    <dbReference type="HOGENOM" id="CLU_1382826_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="22063" checksum="12EAC59CBE8E3F87" modified="2006-07-11" version="1">MQRRNRSSSRHPPLFVLERCAPWRHRACPLLHRVNSRRMAHAAPQLRALEIHSARAHARRTHDTSCINHACIHPAGRLCVRPCFHPESVTHEHDFRGADGAEMNRDAFIVGIAEIPGDITSVEAEKMKSHVFGDTGVLAGVQRSRVRMTDGSEVTDAVYFTDVWQRRDGTWLMVFAHSSPAAPTEAQQAPEGAPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFQ1</accession>
    <name>Q1DFQ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0241"/>
    <dbReference type="EnsemblBacteria" id="ABF90052">
        <property type="protein sequence ID" value="ABF90052"/>
        <property type="gene ID" value="MXAN_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0241"/>
    <dbReference type="eggNOG" id="ENOG5032YN3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151270_0_0_7"/>
    <dbReference type="OMA" id="RFIGQWV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="109" mass="11955" checksum="8E8DE670FED85946" modified="2006-07-11" version="1">MRRACLPALGGRMETDVNPASRASEHEYLDVPPVVRAEHAEASLTRLIEQQTAKVPSHVFLVASLASMGASFVLEVTGRSHLSRFIGQWVSPLLVMGVYNKLVKIFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY3</accession>
    <name>Q1DFY3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0157"/>
    <dbReference type="EnsemblBacteria" id="ABF86524">
        <property type="protein sequence ID" value="ABF86524"/>
        <property type="gene ID" value="MXAN_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0157"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075955_0_0_7"/>
    <dbReference type="OMA" id="FYQTDVK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="28677" checksum="E1572D00529C8903" modified="2006-07-11" version="1">MGVLTSPTRSARGSGRLQHHMVDEQAGATGAAKRTVYCEDALVWLEARPVLEGSSAIASLPDWSEFPSLSLAEWKAWFIRAAALILARVPPEGVAIFYQTDVKDEGTWVDKGYLVARAAEEVGVDLLWHKVVCRRPPGTVTFGRPAYSHMLCFSRGVRVDMAKSTPDVLPEAGEVTWTRGMGVEACLIACRFILEHTRTRTVVDPFCGHGTVLAVANALGLDAVGVELSRKRARKARNLRAELMDGTLVLSGAHGTGAPVGDDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q306N5</accession>
    <name>Q306N5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilN</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type IV pilus biogenesis protein PilN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilN</name>
        <name evidence="3" type="ORF">MXAN_5775</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="1249" last="1261">
            <title>The pilH gene encodes an ABC transporter homologue required for type IV pilus biogenesis and social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Wu J."/>
                <person name="Cheng Y.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9767592"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01013.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="24" last="33">
            <title>The Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pilus biogenesis, social motility, and development.</title>
            <authorList>
                <person name="Wall D."/>
                <person name="Kolenbrander P.E."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9864308"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>New pil genes required for pilus assembly, S-motility, and Tgl stimulation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="6">
        <citation type="journal article" date="2016" name="Science" volume="351" first="aad2001" last="aad2001">
            <title>Architecture of the type IVa pilus machine.</title>
            <authorList>
                <person name="Chang Y.W."/>
                <person name="Rettberg L.A."/>
                <person name="Treuner-Lange A."/>
                <person name="Iwasa J."/>
                <person name="Sogaard-Andersen L."/>
                <person name="Jensen G.J."/>
            </authorList>
            <dbReference type="PubMed" id="26965631"/>
            <dbReference type="DOI" id="10.1126/science.aad2001"/>
        </citation>
        <scope>STRUCTURE BY NMR</scope>
    </reference>
    <dbReference type="EMBL" id="DQ242507">
        <property type="protein sequence ID" value="ABB43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555726.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="3JC8">
        <property type="method" value="EM"/>
        <property type="chains" value="Na/Nb/Nc/Nd/Ne/Nf/Ng/Nh/Ni/Nj/Nk/Nl=1-225"/>
    </dbReference>
    <dbReference type="PDB" id="3JC9">
        <property type="method" value="EM"/>
        <property type="chains" value="Na/Nb/Nc/Nd/Ne/Nf/Ng/Nh/Ni/Nj/Nk/Nl=1-225"/>
    </dbReference>
    <dbReference type="PDBsum" id="3JC8"/>
    <dbReference type="PDBsum" id="3JC9"/>
    <dbReference type="STRING" id="246197.MXAN_5775"/>
    <dbReference type="EnsemblBacteria" id="ABF86305">
        <property type="protein sequence ID" value="ABF86305"/>
        <property type="gene ID" value="MXAN_5775"/>
    </dbReference>
    <dbReference type="GeneID" id="41363018"/>
    <dbReference type="KEGG" id="mxa:MXAN_5775"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081304_0_0_7"/>
    <dbReference type="OMA" id="DRNLPVH"/>
    <dbReference type="OrthoDB" id="1673053at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3JC8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3JC9"/>
        </source>
    </evidence>
    <sequence length="225" mass="24855" checksum="F0CB815B8EA15152" modified="2005-12-06" version="1">MMIRINLLPVRAVKKREMGRQVLVLFAVVLIGAGVANYLWYDDRQSELEAHQAGVASTKARIAELEKIIGEVKNINTRKAEVEKKLAVLDALRKGRSGPVRMMDALASATPKKVWVKTFSENNNAVSIDGSAVSHDEVAEFMRGLNGVVWTPKGMGRLVDRRRDSKTARVEMLTSDATIEEFPEAQVSPFFKNIDLQTAKQVGGAQVGVPILVEFKITMTSNYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVH8</accession>
    <name>Q1CVH8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557394.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7492"/>
    <dbReference type="EnsemblBacteria" id="ABF89439">
        <property type="protein sequence ID" value="ABF89439"/>
        <property type="gene ID" value="MXAN_7492"/>
    </dbReference>
    <dbReference type="GeneID" id="41364625"/>
    <dbReference type="KEGG" id="mxa:MXAN_7492"/>
    <dbReference type="HOGENOM" id="CLU_110224_0_0_7"/>
    <dbReference type="OMA" id="FERHAHA"/>
    <dbReference type="OrthoDB" id="1828352at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="28537" checksum="E39149221D25A358" modified="2006-07-11" version="1">MLSDFSSAHPGGREGWREPGASLGFTAEVPRMQPLPTDRPRAWLFERHAHAVTLKASRSSFERQWGPPHCVVTRDDGRFQEAHWGWRSECGLELVVVSMREADRFHVFIEPLEVDHALAHLGLKDEVVEWRADAGFPLPREGWVVTRMDETGNRYDVAQSPERAHVACFARILEDRAHKQSYYVEFRGTPADEDAARKDWAVIRQDEYGNRAEVARLQCEQGARAFADVYEADPRHKQTYFVEPVAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL2</accession>
    <name>Q1CVL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVR1</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU2</accession>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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                <person name="Mackenzie C."/>
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                <person name="Miller N."/>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="36"/>
            <end position="76"/>
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        <source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13405" checksum="5F1DCE72F0C4C7D4" modified="2006-07-11" version="1">MPLARAVTNVGWRRASIMAQRDKQQQPGIQPPEDYYGRTEEPRQHAPETEESEEKRDLADAAESPEVTHRMRTIDPTERTPGAILDEIGDGDGPRSDAGTNPLPDTYWSAYPYGEPQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVY5</accession>
    <name>Q1CVY5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557244.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7325"/>
    <dbReference type="EnsemblBacteria" id="ABF92591">
        <property type="protein sequence ID" value="ABF92591"/>
        <property type="gene ID" value="MXAN_7325"/>
    </dbReference>
    <dbReference type="GeneID" id="41364488"/>
    <dbReference type="KEGG" id="mxa:MXAN_7325"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_1_4_7"/>
    <dbReference type="OMA" id="TIYTHPL"/>
    <dbReference type="OrthoDB" id="1968136at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="410" mass="45569" checksum="E2C02B38FAD592CF" modified="2006-07-11" version="1">MSLNSGRVDAPTAHAPRLQGHLPVLDGVRGLAVLLVVFFHTTHLSDQSVAGRVTWWLAGAGWTGVDLFFVLSGFLITGILWEAKGQPYFFRNFYMRRFLRIFPLYYLALAVSFLVLPSLAGRLGLDERITTDGAVWYLLYFSNFYQLWVDTTHPILGVVWSLAIEEQFYIVWPFLIAAVSYRGAIRLCLGTIAMAILVRVGLTLYGASIESTYVVTFCRVDSLAMGGLLAMALRHPEGLGLKAFPWMRWAVWASVPVVLALVVLPVGPTFELVKRTGGYTAIAVLYAVCVYKAVAVSKGHVLYRFLTMRLLLTFGKYSYAIYLIHSPLDAILRRTVLKTPLKTVAGSDMPMQLVFYVVAAGLSLGLALVSWNLFEKHMLKLKDYFPYGQRPAPVPEGAQAERTEASARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW53</accession>
    <name>Q1CW53_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557176.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7257"/>
    <dbReference type="EnsemblBacteria" id="ABF91828">
        <property type="protein sequence ID" value="ABF91828"/>
        <property type="gene ID" value="MXAN_7257"/>
    </dbReference>
    <dbReference type="GeneID" id="41364423"/>
    <dbReference type="KEGG" id="mxa:MXAN_7257"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116686_0_0_7"/>
    <dbReference type="OMA" id="LGHENAP"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="21540" checksum="EF4DD5106F3FBFAB" modified="2006-07-11" version="1">MNTMTAEFIKALDWHTEWLRSGGQNGKRLHLEDADLSLLDLSSRDLSEAALPGARLDGCILDRTKLAHANLASASFIGASLSRAQLSKANLDYALLRGAILTQVNALRASFGEADLQGADLQGADLQGAYLVSANLASANLRDAHLEGAVLHGARLSGADLRGASGLQATQASWIDLGHENAPVRVEGEALRSWLAQATMKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWF9</accession>
    <name>Q1CWF9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligoribonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">orn</name>
        <name evidence="2" type="ORF">MXAN_7151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557070.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7151"/>
    <dbReference type="EnsemblBacteria" id="ABF86589">
        <property type="protein sequence ID" value="ABF86589"/>
        <property type="gene ID" value="MXAN_7151"/>
    </dbReference>
    <dbReference type="GeneID" id="41364325"/>
    <dbReference type="KEGG" id="mxa:MXAN_7151"/>
    <dbReference type="eggNOG" id="COG1949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_2_0_7"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="OrthoDB" id="1390327at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="21043" checksum="F546D42A7389A055" modified="2006-07-11" version="1">MISSEQRFVWLDLEMTGLDPETCSIIEVGVIITGPDLRPIAEIERVIWQPEEVLLRMEPVVREMHTRNELLEKVRASNTSLRVAERDVMALVTEHCALGEGILAGNSIHTDRRFLIRYMPLLERYLHYRMVDVTSLKVLTRAWYPNLVEPRKAPSGHTALADVRASISELQYYRDTLFRGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ1</accession>
    <name>Q1CWQ1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574240">
            <id>Q1CWQ1</id>
        </interactant>
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
            <label>MXAN_2606</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574240">
            <id>Q1CWQ1</id>
        </interactant>
        <interactant intactId="EBI-1574080">
            <id>Q1D8M1</id>
            <label>MXAN_2785</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556978.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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</entry>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <location>
            <begin position="134"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
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</entry>
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    <accession>Q1CXL8</accession>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="38" mass="4223" checksum="7BCACE9B46B02A7E" modified="2006-07-11" version="1">MASGTTSPRLNSHIITLKARLQRMAQVHEQPSGQRSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY17</accession>
    <name>Q1CY17_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6585</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
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                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
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    </reference>
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    <dbReference type="STRING" id="246197.MXAN_6585"/>
    <dbReference type="EnsemblBacteria" id="ABF86782">
        <property type="protein sequence ID" value="ABF86782"/>
        <property type="gene ID" value="MXAN_6585"/>
    </dbReference>
    <dbReference type="GeneID" id="41363788"/>
    <dbReference type="KEGG" id="mxa:MXAN_6585"/>
    <dbReference type="eggNOG" id="COG3287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052774_2_0_7"/>
    <dbReference type="OMA" id="FYCAGRR"/>
    <dbReference type="OrthoDB" id="1942718at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="37"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="2">
        <location>
            <begin position="235"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="40970" checksum="D52C6605017256DA" modified="2006-07-11" version="1">MNIDSSGMRMQIGKSCSPDCEVAAREAGAEALRGADAPTFALVLCTDQYDADDLASALRRELRDLPWAGCCAAGVFAGTELLHQGLVVALFRGMDLQVGTGMGGPVSKDPRAAGRDAVARAIEKLPPMRPGRRRALLVFPDALSGNPTEVVRGAQQEAGAGVVWAGGGAGGDLRSAMTAQFTNGQAYRDRVVVIAFDAQAPIGVGIQHGWYPYGPPTQVTKAHGATAIELDYESAFEVYRRTAASRGDALDVQGFARFAMTHPLGIPQANGEFVIRELISIGPDGSVRCVAEIPDGSLVRVMEGARADLLDAAAGAATLARTGTPGALGGAVVFDCFSRYPILGEEIQDELSRVQGALGEATPLVGCLTLGEVGAMGGGVPQFHNKTVVVLALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYJ2</accession>
    <name>Q1CYJ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6407"/>
    <dbReference type="EnsemblBacteria" id="ABF86512">
        <property type="protein sequence ID" value="ABF86512"/>
        <property type="gene ID" value="MXAN_6407"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6407"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813347_0_0_7"/>
    <dbReference type="OMA" id="HEAWELE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="381" mass="41466" checksum="BE79B16A592394DD" modified="2006-07-11" version="1">MSEPFWESDAPPVQDPAALYFAGSGRRPPPEPAAPEAEDDKHARLAAAEQVASQSPANVAPGNLTVPCPLRGAHTIEVRVIGSDDAPLENVTLVLEKSESEVLIAKTDADGLARFRGLAMGKYQLHPRELDHEAWELESSEKLPPERDRCDTNAAWQAPSGPDTREAITHVVQAGECISTLAYRHGHLPETLWNAEENAALKELRGDKNILNPGDSVVIPAPRRGTEGVDAGNAYLLRGKGFTETLRVRFLDAEGQPRVKLPYVVSLESDVRTEERAGATNSEGFLVEPASASVHTLKVTFGSGSKREAYAFQVARLAPLDTLAGAQARLCHLGYSCGEEDGVMGPWTRRALRDFQRDHDLPVTCELDDATRTRLRAEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM4</accession>
    <name>Q1CYM4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6375"/>
    <dbReference type="EnsemblBacteria" id="ABF87328">
        <property type="protein sequence ID" value="ABF87328"/>
        <property type="gene ID" value="MXAN_6375"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6375"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2451537_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="89" mass="9775" checksum="84E3D4F443A30A47" modified="2006-07-11" version="1">MTSTRPPLTRGGHFWPCASELQGVRSRAKLGFHLGFYVDSEDLVTQFHARAKGDGLEVSEVIRNNRGTMVYCTAPGGLLIEVNCRPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM6</accession>
    <name>Q1CYM6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="12">ATP-PFK</shortName>
            <shortName evidence="12">Phosphofructokinase</shortName>
            <ecNumber evidence="12">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">pfkA</name>
        <name evidence="14" type="ORF">MXAN_6373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556305.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6373"/>
    <dbReference type="EnsemblBacteria" id="ABF87778">
        <property type="protein sequence ID" value="ABF87778"/>
        <property type="gene ID" value="MXAN_6373"/>
    </dbReference>
    <dbReference type="GeneID" id="41363586"/>
    <dbReference type="KEGG" id="mxa:MXAN_6373"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_7"/>
    <dbReference type="OMA" id="TNRDNPF"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="13">
        <location>
            <begin position="2"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="12">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="345" mass="37044" checksum="8109152D02E586F8" modified="2006-07-11" version="1">MKVAVLTGGGDCPGLNAVIRAVVRRANAHGFEMMGLRDGWKGLLEDNHFRLTRETTSGILHRGGTILGTSRVNPFKVENGLERVKRAIERNGIHAVIAIGGEGTLSAATRMSQEGLRIVGVPKTIDNDINATDFTFGFDTAVAIATEAIDRLHSTAESHKRVIVCEVMGRHVGWIATYAGIAGGADVILVPEIPADLAKVAEHIQRRHAGGRTFSIVVVAEGTRIKLSADQQEQLVTSGALDEAGRPRLGGVGTILAHEIERRTGFETRVSVLGHIQRGGAPTAHDRVLATRYGVHACDMVARGEFGKMAALRGNDIISVDLADATRELKRVPQEFFEVAQVFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYU0</accession>
    <name>Q1CYU0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6308"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89856">
        <property type="protein sequence ID" value="ABF89856"/>
        <property type="gene ID" value="MXAN_6308"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6308"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775479_0_0_7"/>
    <dbReference type="OMA" id="HACRLSW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="40"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="43406" checksum="D679C0444258A405" modified="2006-07-11" version="1">MDGQETHAPPHEGRHAHGHDATSNRAVRRVLMTADAVGDVWTYALELTRALAPHGVEVTLATMGAPLTSAQWAEARGIPNLTVEEGRFRLEWMEDPWDDVRSAGDWLLALERRVRPDVVHLNGYVHGALPWLHRPLVVGHACRLSWWRAVKGEDAPACHARYREAVTAGLGAAGRVVTPSRDLLDSLQMHYGPLTAAEVIPHGRRADRVPPRSEREPFILGVGSPWDAAKNLTVLDAAAPRLGWPVRLAGDARHPSERKAEPRHLQWMGHLEPHVLAAWMSRASIFVLPARYAPFGLTALEAALSGCALVLGDIPALREVWGDGAACFVPPDDVDALVETLERLREDTGLRTRLALRARAWALTYTPRRMASRYLSAYASLVGTQGVLSPAGTPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV4</accession>
    <name>Q1CYV4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3600</name>
        <name evidence="2" type="ORF">MXAN_3615</name>
        <name evidence="3" type="ORF">MXAN_6293</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553623.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3600"/>
    <dbReference type="EnsemblBacteria" id="ABF86016">
        <property type="protein sequence ID" value="ABF86016"/>
        <property type="gene ID" value="MXAN_3615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87600">
        <property type="protein sequence ID" value="ABF87600"/>
        <property type="gene ID" value="MXAN_6293"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90983">
        <property type="protein sequence ID" value="ABF90983"/>
        <property type="gene ID" value="MXAN_3600"/>
    </dbReference>
    <dbReference type="GeneID" id="41364777"/>
    <dbReference type="KEGG" id="mxa:MXAN_3600"/>
    <dbReference type="KEGG" id="mxa:MXAN_3615"/>
    <dbReference type="KEGG" id="mxa:MXAN_6293"/>
    <dbReference type="eggNOG" id="COG5659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033141_3_1_7"/>
    <dbReference type="OMA" id="RRWTSWH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="45220" checksum="B2F111CF7502DD41" modified="2006-07-11" version="1">MNAAAVQRLERYFQQIGEVLGEESRRGSFALYAMGLLGEGERKSVEPIAARACPDPERVDAMHQRLLHFAVDSRWSDRDVRRQAARYALEAMTRREPVEAWIVDDTGFLKQGKHSVGVQRQYTGSAGKVANCQIGVSLSVATRTEHLPLDFELYLPECWTNDAARRREARIPDDVPFKTKPQLALQMIERAVQDGAPPGVILGDTAYGTSSQFRAHLRALGLHYAVAVDPQTTVSVLDAQGRPRGNVRSVSALALHIHERGGFRRCTWRQGPQRDLSARFALRRVVAAGVPQREQEPLWLLIEWRDGEAEPANSFLVSLPGFRTKKQLIRLVMQRWRTERVYEELKGELGLDHYEGRRFPGWHHHVSVALCCYAFIVAERVRRFPPSARGAAEAYAQPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ60</accession>
    <name>Q1CZ60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556126.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="227" mass="26356" checksum="29ED0B5333BA9C7D" modified="2006-07-11" version="1">MPKAKTPKPPDSLEVRVRRIHRRDLNRTWEFLKLVFRDVNRETVEYQRPRSKRRFLEVYTSEWIEQLLYEVDGSIVGYSECAFEATGDDNWVNPRWFEKRGMRPLFVEELAVHPDYQGRGVGSFMLDQLQHLARTRGCTHLVLEVAENNESALTWYRTRSFYKLDAAIFMAQKVPGEPDLLPPRRLKRRQKPTVETGTPSTGPMPETAPTRAAARKGRAPAARKKSS</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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        </location>
    </feature>
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        <location>
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        </location>
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    </feature>
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            <end position="1021"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
            <position position="53"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50110"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF87731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="218" mass="23780" checksum="89D72B9B93792A7F" modified="2006-07-11" version="1">MRVLLTDDHQLVRAGLRALLESLGGVTVLAECGDGHEALTLTDKLQPDVLLLDLSLPGLNGIEVARRVPKLSPSTRILILSMHTSAEYVAQALRAGVAGYLVKDSAVEELKVALESVWQGRTYLSPAISQTVVEGFLRITDDERPAANPLDRLTSRQREILQLISEGNGTRAIAERLQVSVKTVEAHRTQLMERLAIYDVPSLVRLAVRYGLVPGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA0</accession>
    <name>Q1CZA0_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Kim H.S."/>
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                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6142"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_027269_1_2_7"/>
    <dbReference type="OMA" id="MNANLEV"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1254" evidence="2">
        <location>
            <begin position="68"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="1">
        <location>
            <begin position="339"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="480" mass="53176" checksum="336F52F53F533A4E" modified="2006-07-11" version="1">MSLATGCSNSISFQLPKPRSGMPITISLTEARAIAKDAYLYGWPLSENYNTIYAYSIDPENPNYKAPFNQIFNDSKVFTPADTAIVTPNSDTPYSFITADLRAEPLVISVPAMVPDNRYFSFQLIDLYTYNFSYIGTRATGNGGGHFLLAGPSWESGGDRSDFAGICYSASHFALLIGRTQLFEPDEISAVQDLQSQYKVQTLSEFRGDSKPPQALPISWPLPITGDKSKTPEVFGVINFMLQFCPTNPTEVGLMERFARIGVGAGLPFDVKSLSPDMLKAFEEGIADAWKEFEDLNKEVATGEADSNDFFGARESNNNNYLYRFAGAKIGIYGNSKQEAIYPMYSVDDAGQIPDGSTSKYTITLAKDEMPPAQAFWSITMYDAKTQLLINNPIKRYLVNSAMLEMGEFKTGEDGSLTFYLQKACPRKEDGEKKNWLPAPAAPFYAVMRLYVPEPRAYEGADRWIPPPMKRAGSVSEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZK2</accession>
    <name>Q1CZK2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="5 10">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sucB</name>
        <name evidence="14" type="ORF">MXAN_6036</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="10">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555985.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6036"/>
    <dbReference type="EnsemblBacteria" id="ABF93126">
        <property type="protein sequence ID" value="ABF93126"/>
        <property type="gene ID" value="MXAN_6036"/>
    </dbReference>
    <dbReference type="GeneID" id="41363274"/>
    <dbReference type="KEGG" id="mxa:MXAN_6036"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_7"/>
    <dbReference type="OMA" id="MKVPSPG"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF93126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="398" mass="42344" checksum="724A53D8170E8DF8" modified="2006-07-11" version="1">MAVEIKVPPLGESITEAVVGKWNKKPGDAVTADEPLVVLETDKVTIDVPAPSAGSLSSIAFKEGDKVRVGEVLGLLEAGAGAPAARPAAAPAPAAAPAPAAEVPAASDARSTPTARKVAEENRLDISQVKGSGAGGRVHKDDVLGQLNRPATPAAPAQPAGPRPNAAREERVRMTPLRKRVAERLIQAQSTAAMLTTFNEVDMGEVMALRKKYNDKFQQKHGVKLGFMSFFIRASVEALKAFPQINAEIDGEDVIFKHYYDIGVAVSGSRGLVVPVVRNADKQGLAELEKSVGELGTKARNDKLALADLQGGTFTITNGGIFGSMLSTPILNPPQTGILGMHNIVERPVARDGQVVIRPIMYIALTYDHRLVDGREAVQFLVRVKECIEDPERLLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZP6</accession>
    <name>Q1CZP6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 3</fullName>
            <shortName evidence="5">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">prfC</name>
        <name evidence="7" type="ORF">MXAN_5992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555941.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5992"/>
    <dbReference type="EnsemblBacteria" id="ABF86857">
        <property type="protein sequence ID" value="ABF86857"/>
        <property type="gene ID" value="MXAN_5992"/>
    </dbReference>
    <dbReference type="GeneID" id="41363231"/>
    <dbReference type="KEGG" id="mxa:MXAN_5992"/>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_7"/>
    <dbReference type="OMA" id="TPASWPI"/>
    <dbReference type="OrthoDB" id="164090at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="10"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="541" mass="60782" checksum="D509016920083BC6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D096</accession>
    <name>TRMB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">MXAN_5790</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555741.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D096"/>
    <dbReference type="SMR" id="Q1D096"/>
    <dbReference type="STRING" id="246197.MXAN_5790"/>
    <dbReference type="EnsemblBacteria" id="ABF88297">
        <property type="protein sequence ID" value="ABF88297"/>
        <property type="gene ID" value="MXAN_5790"/>
    </dbReference>
    <dbReference type="GeneID" id="41363033"/>
    <dbReference type="KEGG" id="mxa:MXAN_5790"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_0_7"/>
    <dbReference type="OMA" id="GHALEYC"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000288186" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="206" mass="23312" checksum="3CA68D7EBAA744DF" modified="2006-07-11" version="1">MSRPRLLPEPVGLKFVTQETPPDWDAEFGFSGPLELEIGSGAGGHALEYCRRHPEVRFVAFEWRKKYARDTQDRADKAGLRNLRVIESDARFIVPRIFAPDSLAAIHLQFPDPWWKRSHAKRAVIQPAFAELLYGKLAPGGLFDMRTDVQDRGVTMLAILESVGFKNPLGSGVFHPYDPEEVPSTRERRYLASGEPVYRARLLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D1</accession>
    <name>Q1D0D1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555706.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5755"/>
    <dbReference type="EnsemblBacteria" id="ABF92906">
        <property type="protein sequence ID" value="ABF92906"/>
        <property type="gene ID" value="MXAN_5755"/>
    </dbReference>
    <dbReference type="GeneID" id="41362998"/>
    <dbReference type="KEGG" id="mxa:MXAN_5755"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068865_0_0_7"/>
    <dbReference type="OMA" id="IARWRIE"/>
    <dbReference type="OrthoDB" id="1425499at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="28063" checksum="69500F896C721CCC" modified="2006-07-11" version="1">MTPSAVSHSLLVTRSTRMSRFVVVSVVGHILVLVAAIAYARFSATPKVDLDTKPIRATLVRLGKPRDSKLLPRKEQLPPPPKKVDAPKPAPEAPPPEPSPAKVAVPIPGVQPEPSTSKPTPQKGETTGEDRRKRLFGAFDKTAKAAEPEEAEGAEDGDPDGDSATAEGERYFGLLQSQVRRHYSVADTIPESERLHLKAMVAVRLGRTGEVLDVSLTKASGNDLFDSAVVTAVRKAAPFSPPPDHLRNALQKSGVNLVFNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0E2</accession>
    <name>Q1D0E2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxyl-terminal protease family protein</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555695.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5744"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="ABF93114">
        <property type="protein sequence ID" value="ABF93114"/>
        <property type="gene ID" value="MXAN_5744"/>
    </dbReference>
    <dbReference type="GeneID" id="41362987"/>
    <dbReference type="KEGG" id="mxa:MXAN_5744"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_1_2_7"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188216" evidence="5">
        <location>
            <begin position="26"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF93114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="49891" checksum="D21EB1AB6310A404" modified="2006-07-11" version="1">MTGSSQPWRAALTAFFLLSAPWAHAAEPLRKDAGTAGRAEQAERDDATYRQLEVFARVLSYVENNYVESPDRQRLMYGAIQGMLETLDPHTVFLPPDVYREMKIDTSGEWGGLGIEIARKGERIVVVAPIDDTPAARAGIKAGDELVGIDGERTEGMDVGRALQKMRGPAGGRVLLTIMREGFSAPREIAIIRDHIRIVSVEGALHGGIGHVKVKNFQDRTDLYLRKELDRLRALNGGKELRGLVLDLRNNPGGLLDQAVAVSDRFLPGNLPIVSTRGRDGRSATVERSKDRDTEKDYPVVVLVNAGSASASEIVAGALQDHGRATILGAPTFGKGSVQTVIELEDGSGLKLTIARYYTPKGRSIQERGITPDFLVPDEPGGKVPRDVVREKDLRRHFRAEPTAATEPAAPEPRGLPENLKPWDVTAKLEDYPLRVALDYLHGMASAPARTPSRAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0G8</accession>
    <name>Q1D0G8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative phosphoglucomutase/phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_5717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555669.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5717"/>
    <dbReference type="EnsemblBacteria" id="ABF88119">
        <property type="protein sequence ID" value="ABF88119"/>
        <property type="gene ID" value="MXAN_5717"/>
    </dbReference>
    <dbReference type="GeneID" id="41362962"/>
    <dbReference type="KEGG" id="mxa:MXAN_5717"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_7"/>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="9">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="10">
        <location>
            <begin position="226"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="11">
        <location>
            <begin position="326"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="8">
        <location>
            <begin position="489"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF88119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="575" mass="61156" checksum="D19CCD57EA27C679" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R8</accession>
    <name>Q1D0R8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555570.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5616"/>
    <dbReference type="EnsemblBacteria" id="ABF90639">
        <property type="protein sequence ID" value="ABF90639"/>
        <property type="gene ID" value="MXAN_5616"/>
    </dbReference>
    <dbReference type="GeneID" id="41362862"/>
    <dbReference type="KEGG" id="mxa:MXAN_5616"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_3_7"/>
    <dbReference type="OMA" id="CPLYFED"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="257"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="601" mass="65050" checksum="3C962B27F565453A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1D0</accession>
    <name>Q1D1D0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5396"/>
    <dbReference type="EnsemblBacteria" id="ABF92119">
        <property type="protein sequence ID" value="ABF92119"/>
        <property type="gene ID" value="MXAN_5396"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5396"/>
    <dbReference type="HOGENOM" id="CLU_2233625_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="105" mass="11185" checksum="76DAA6D54C40E2B5" modified="2006-07-11" version="1">MLVRLELVESLCSKVGTHSAIVRAKTSGFFELMLTQPVRRAQWFWGLLLARVAALIGAARARAGARRGGARGLLAGQLPGTHPGAGHRRGVARAAGRTHHQARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F6</accession>
    <name>Q1D1F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555332.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5367"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90189">
        <property type="protein sequence ID" value="ABF90189"/>
        <property type="gene ID" value="MXAN_5367"/>
    </dbReference>
    <dbReference type="GeneID" id="41362635"/>
    <dbReference type="KEGG" id="mxa:MXAN_5367"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_7"/>
    <dbReference type="OMA" id="DMICAFR"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="29960" checksum="EB2AB3A784B53244" modified="2006-07-11" version="1">MAQYPSISLFFPAWNEEDYVERAVSRALEVLPALTDDFEIIVVNDASTDRTREVCEALAQKVPQLRVIHHPVNLKLGGAMRTGLAASTKDIVVYSDVDLPWDMRELERALHLMSYLEADMICAFRFDRTSEGAKRIIYSFVYNMLIRSLFDIQIKDVNFSFKVMHRRVLEAMELHSQGSFIDAELVVKAIRQGFRVFQMGVDYFPRTRGVSTLASPSVITKMVRELVKLYPKMRAPQPPVHPVRLPPSVQQLHAVPPGRTARG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H1</accession>
    <name>APT_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">MXAN_5352</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555317.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D1H1"/>
    <dbReference type="SMR" id="Q1D1H1"/>
    <dbReference type="STRING" id="246197.MXAN_5352"/>
    <dbReference type="EnsemblBacteria" id="ABF91841">
        <property type="protein sequence ID" value="ABF91841"/>
        <property type="gene ID" value="MXAN_5352"/>
    </dbReference>
    <dbReference type="GeneID" id="41362621"/>
    <dbReference type="KEGG" id="mxa:MXAN_5352"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_3_7"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000321373" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="184" mass="19838" checksum="C64335407BB936DE" modified="2006-07-11" version="1">MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRGQHVTKVVGVEARGFLLGAPIALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHEDAILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCFLLSLDFLEGPNRLGRERVTTLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1U3</accession>
    <name>Q1D1U3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
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        <property type="protein sequence ID" value="ABF87742.1"/>
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    </dbReference>
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        <property type="gene ID" value="MXAN_5228"/>
    </dbReference>
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        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29344" checksum="905378FF8CC72C47" modified="2006-07-11" version="1">MSNRCTRRCVTPPGFTSADPFPYLGANLMKRLIQGLSLTSLCLSLAACGANKYYTLPVDSHDASTTKTSIGVCALESGLESQSMDNTAIAVTYDATSTMYYRYNGKDAYTFQVSVDDKQVPPEELEAKLATVRKKGEELYLCAQDRINPRFVAAPTHAPAQTNVTINLNAPDANSRDSLSAGASVSTNTNTASASTTSSSASVDLGEGTCARAVDCYARLAKTVCEGAQDCSFKVEMSGNDEASCRDALLRVPDLIQPFKMIRPNLSAPAVCRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D203</accession>
    <name>Q1D203_MYXXD</name>
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        <submittedName>
            <fullName evidence="10">Efflux ABC transporter, permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">MXAN_5167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">DK1622</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_5167"/>
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    <dbReference type="KEGG" id="mxa:MXAN_5167"/>
    <dbReference type="eggNOG" id="COG1132">
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    </dbReference>
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    <dbReference type="OrthoDB" id="643917at2"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
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    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABCB10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF553">
        <property type="entry name" value="PTHR24221:SF553"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
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        </ligand>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="585" mass="63741" checksum="ED7D450B5BB4A47A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D210</accession>
    <name>Q1D210_MYXXD</name>
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        <submittedName>
            <fullName evidence="7">DoxD-like family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">MXAN_5160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
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    </dbReference>
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        <property type="entry name" value="DoxX"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="13544" checksum="9F55B4466D6E5975" modified="2006-07-11" version="1">MVGKSAVGLTLIRVVFGLSLALGHGLPKLTGDMSKFAAGVAQLGFPFPTFFAWCATLAEFLGGLLVAVGLFTRPAAAMAGFTMAVALYRHRADPFGRMEMALLYLAVMAGIALIGAGPWSLDAKVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D220</accession>
    <name>Q1D220_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555121.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5150"/>
    <dbReference type="EnsemblBacteria" id="ABF88026">
        <property type="protein sequence ID" value="ABF88026"/>
        <property type="gene ID" value="MXAN_5150"/>
    </dbReference>
    <dbReference type="GeneID" id="41362433"/>
    <dbReference type="KEGG" id="mxa:MXAN_5150"/>
    <dbReference type="HOGENOM" id="CLU_2118421_0_0_7"/>
    <dbReference type="OMA" id="GMLLCHA"/>
    <dbReference type="OrthoDB" id="2009582at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="123" mass="12663" checksum="DD33A3F0DA14A15A" modified="2006-07-11" version="1">MEPPGHVRGMLLCHAGPHRLAFHAHEVASIASPSGHAAASARRAFHETEGSARVLVSASGGAVGVDALEIDAEPHRVLPAPPVTVRASGGSLQGFVMARGALWPLVGLADFERFLRGHPGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D228</accession>
    <name>Q1D228_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5142"/>
    <dbReference type="EnsemblBacteria" id="ABF90927">
        <property type="protein sequence ID" value="ABF90927"/>
        <property type="gene ID" value="MXAN_5142"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5142"/>
    <dbReference type="HOGENOM" id="CLU_3218990_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188163" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4396" checksum="A103AF61BE792276" modified="2006-07-11" version="1">MSPRPVKLAALALLLLLPLVAGAAPKQLVLLFTGDNGGEVAPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D229</accession>
    <name>Q1D229_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555113.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5140"/>
    <dbReference type="EnsemblBacteria" id="ABF88716">
        <property type="protein sequence ID" value="ABF88716"/>
        <property type="gene ID" value="MXAN_5140"/>
    </dbReference>
    <dbReference type="GeneID" id="41362424"/>
    <dbReference type="KEGG" id="mxa:MXAN_5140"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911250_0_0_7"/>
    <dbReference type="OMA" id="WVERVEP"/>
    <dbReference type="OrthoDB" id="1326136at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="32602" checksum="CAF3B20CA7891CFE" modified="2006-07-11" version="1">MLVLDAGNALFKSRDSAQAPDARARAELVLSQMDAQGTAAMAVGARDLGFGVGFLKKQTRQAKLKLLSANLADAQGKLLFPASLVTTVGGVKVGVVGVSPAMAKPTPVGLAVPGQAQEQVQGLPVQPAVAAEAKRLREKSKVDLVVVLAAVPHAEALQLADQVEGVDFVVQSHEGRGQGIAQRQALATVIPSGARGRELAKLLLQLEGTGRFADASVQERTRQQLRLLEGNLTRAKARLAGTQDPAEKQPLEATIARLEASRAAYQKALAGGATDAGRTHLLSYIQLGSDVPADPVVQKWVERVEPPGSAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D256</accession>
    <name>Q1D256_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555087.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5113"/>
    <dbReference type="EnsemblBacteria" id="ABF92974">
        <property type="protein sequence ID" value="ABF92974"/>
        <property type="gene ID" value="MXAN_5113"/>
    </dbReference>
    <dbReference type="GeneID" id="41362397"/>
    <dbReference type="KEGG" id="mxa:MXAN_5113"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_1_7"/>
    <dbReference type="OMA" id="NYSTHIY"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="159"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="32897" checksum="C8053B2C1BAFC94B" modified="2006-07-11" version="1">MKPRKQAVPRRLRRVLVATDFSEASTHAVGRAGHLPLADGAKVLVTHVLPSRMPAEVGSRALQATARELERVAERLRNMLRAEGSSATVDTHIARGKPVEAILRRARAFGAELIVLGRHGDKPLRNMFLGSTAENVIRGGDLPVLIANRRAPGPYLRPVVAVDADETSKRAASFVPTLMTPGSELTLVHAYDVPLEYAVFPGLTAKEYKHYRQTFKATAERKLKALQRELDAVDIPYHLVMESGGSRSIVLEFVDDQGADLLALGTRARSGVAFALLGSVATDLIREAKCDVLVVREAEPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D297</accession>
    <name>Q1D297_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">tdk</name>
        <name evidence="12" type="ORF">MXAN_5072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555047.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5072"/>
    <dbReference type="EnsemblBacteria" id="ABF92262">
        <property type="protein sequence ID" value="ABF92262"/>
        <property type="gene ID" value="MXAN_5072"/>
    </dbReference>
    <dbReference type="GeneID" id="41362356"/>
    <dbReference type="KEGG" id="mxa:MXAN_5072"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_7"/>
    <dbReference type="OMA" id="GWLELIC"/>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF92262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22126" checksum="44F9BD1D65B32603" modified="2006-07-11" version="1">MHQFPKDIGWIEVICGSMFSGKTEELIRRVQRAVYGKQKVQVFKPRIDNRYDESAVVSHSQHKVLSTAIERAEEIFYRLAPDTQVVGIDEVQFFGSEVVAVVEALANKGLRVICAGLDQDYQGRPFEPMPQLMAVSEYVTKELAICVVCGNPANRSQRIVSSGERVVVGAAGAYEPRCRKCHVAEPAEGTPPQTLELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B7</accession>
    <name>Q1D3B7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ORF">MXAN_4690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554681.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4690"/>
    <dbReference type="EnsemblBacteria" id="ABF92966">
        <property type="protein sequence ID" value="ABF92966"/>
        <property type="gene ID" value="MXAN_4690"/>
    </dbReference>
    <dbReference type="GeneID" id="41361989"/>
    <dbReference type="KEGG" id="mxa:MXAN_4690"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_1_1_7"/>
    <dbReference type="OMA" id="FMAIVVY"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="392" mass="42406" checksum="469FC6B760FC6587" modified="2006-07-11" version="1">MQIFKNKTNIDFISKRKPALFISTLLNLAIIVGIAAFGFNFGVDFAGGTVVEVKFDHPITAEEVRERADKGGLPDVSVQNIGAAEENTFLLRMGGVTQLNEESGAKGKEALEALGGVRNVYSDLPNGIIRFRAAQPMDSDAVKKAVESAGIGVQEVRDLGEAQGGTGYDYQVVASGMADRVFAALNAGLEKPDFEQRRVDYVGPQVGKQLRNRGIMALLYSMVAILIYVAFRFDFKFGPGALLSMVHDVIMVAGYYLVSRREFNLTAIAALLTVVGYSVNDTIVIYDRIREDMAKYKGKPFAEVINIAINDTLGRTILTSGTTALSLIGLLIFGVGEIFDFAMAMLVGIVVGVYSTIYIASPLTIWLDERAAAKDARLRASGNVDHQQPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3E6</accession>
    <name>Q1D3E6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554653.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4661"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87318">
        <property type="protein sequence ID" value="ABF87318"/>
        <property type="gene ID" value="MXAN_4661"/>
    </dbReference>
    <dbReference type="GeneID" id="41361961"/>
    <dbReference type="KEGG" id="mxa:MXAN_4661"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558759_0_0_7"/>
    <dbReference type="OMA" id="AILEHAY"/>
    <dbReference type="OrthoDB" id="1854992at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="463" mass="48236" checksum="D39389A57226F69B" modified="2006-07-11" version="1">MKPQNPHAQEDRLLDFAYGELPVPEARLVEAHLESCARCTQALDDIRGVRATMSQLSVEPAPDAGLESLMAYAQQAARRAAAGPAPKPSRWRRWLLPVLGLASVSTFGLLTLEARSPDLTRPDLSAAKVAVAKEELVAPPAADGFAPAAPAAAAPAPAAALTMPAEAEAAGYAAREMAAPTKSKGAERSREQRPLAEDWANAGSGGGLDMRIRRESESKAKRGPPAAARAPKADMRAALEPAPMAQEVAPSSLDEESKVESESMDLQTPPADSDDAFAGRSERRVADSQAPRSVPPRDSLRLGAKSPAARGAAYDDELDASESKGTLGGVAAPAKAEPQRPAPAPAPASKKSAPTAAPPPPPVERANVAELSRQARAAFAAGEGARAAGLIRSALASGATGQERWTLLNQLCEFEFALGRRAEGLEACNLVIQEAPASEAARSARRRVARESSANEMPAKPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3H0</accession>
    <name>Q1D3H0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002636699.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4637"/>
    <dbReference type="EnsemblBacteria" id="ABF92206">
        <property type="protein sequence ID" value="ABF92206"/>
        <property type="gene ID" value="MXAN_4637"/>
    </dbReference>
    <dbReference type="GeneID" id="41361937"/>
    <dbReference type="KEGG" id="mxa:MXAN_4637"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_4_3_7"/>
    <dbReference type="OMA" id="KNRVMLM"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="11595" checksum="7DB12DD9F7DC388D" modified="2006-07-11" version="1">MATGETGIIGKGIVIKGNLTGGGDLVIEGRVEGQIALKNHLTIESTGKVQADIRAEELTINGEASGNIDASSRVAINASAKVAGDIKAPRVVIEDGAVFNGSIEMDVRLPDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D434</accession>
    <name>Q1D434_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92893">
        <property type="protein sequence ID" value="ABF92893"/>
        <property type="gene ID" value="MXAN_4418"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4418"/>
    <dbReference type="HOGENOM" id="CLU_1298671_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="22681" checksum="6042D5F1315A7063" modified="2006-07-11" version="1">MSQPFWLFWFFENISVAGRWMMEIAGGWLVARLADSAAQVASLISIASIPVLVSMAWAGQVADRYDRRRTVLLMGPGLAVTAPRWAGMRLVCAPLVVGLAQVGLSYSTSPLGAAVMLAISSFGIATLAGLTLMFIQLTCPQDLQGRLLGLHNILFAVVPPAGIVMGMLTHYVELRVSMRFFGLLFAGVSTAWLLLARIGSADLTRAEGNGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D475</accession>
    <name>Q1D475_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4375"/>
    <dbReference type="EnsemblBacteria" id="ABF92080">
        <property type="protein sequence ID" value="ABF92080"/>
        <property type="gene ID" value="MXAN_4375"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4375"/>
    <dbReference type="HOGENOM" id="CLU_119555_0_0_7"/>
    <dbReference type="OMA" id="RCIRAYG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188211" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="149" mass="16330" checksum="2EC3D4B3C62D9BD9" modified="2006-07-11" version="1">MISPLFMQNQNNPLNLSCVLVALALGCSSSATGTASRRDAYALATCTDTVTCCIQRNPGMPEACGLTASEAASHMAGVKMVIEAAEEAPAEWDDTHNANLPEWKRRCIRAYGDCQEFDWTGSCHDCLRSCEGQQAWPEDKCSPRRKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D476</accession>
    <name>Q1D476_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554375.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4374"/>
    <dbReference type="EnsemblBacteria" id="ABF91786">
        <property type="protein sequence ID" value="ABF91786"/>
        <property type="gene ID" value="MXAN_4374"/>
    </dbReference>
    <dbReference type="GeneID" id="41361685"/>
    <dbReference type="KEGG" id="mxa:MXAN_4374"/>
    <dbReference type="HOGENOM" id="CLU_078790_0_0_7"/>
    <dbReference type="OMA" id="WAEDGKR"/>
    <dbReference type="OrthoDB" id="1095639at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011754">
        <property type="entry name" value="Mxa_paralog_2268"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09544">
        <property type="entry name" value="DUF2381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02268">
        <property type="entry name" value="TIGR02268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187862" evidence="2">
        <location>
            <begin position="25"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="32884" checksum="7C032966BBA21977" modified="2006-07-11" version="1">MSVPTPLPIPLALALLLAAEPTRAQPATCREPTERPVELGAERCGRPPEIRVGEGVATVLRFDTPLMRAEVSGPGRFRQVVDRELLILVPEEPVADESRATLTVYFADGAVPIQATLQLVIETPARAERQVELFRRARTAASFQRELLETRRVLQEVREENARLRAAQARPGGLMGLWVSGDMGRTGVAAREFLDVREHARNSLVLRSGLTFRARSILVVVGLKNPLGAKPWQATGAALVGPDGAELKVARVWAPASLNPGDEMDVLVETEPVEGAPRGPFTLTLWAEDGKRPIILGNIEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D495</accession>
    <name>Q1D495_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YceI-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554356.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4355"/>
    <dbReference type="EnsemblBacteria" id="ABF86338">
        <property type="protein sequence ID" value="ABF86338"/>
        <property type="gene ID" value="MXAN_4355"/>
    </dbReference>
    <dbReference type="GeneID" id="41361667"/>
    <dbReference type="KEGG" id="mxa:MXAN_4355"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_7"/>
    <dbReference type="OMA" id="FAMNYNQ"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="19823" checksum="FCD695C1C1949FF9" modified="2006-07-11" version="1">MATTTWNIDTTHSAIHFSVRHMVIAKVRGSFRKYSGAISLDEQDITKSSVAVTIETASIDSGVEQRDTHLRSPDFFDVEKFPSITFKSTKVEKASGNGLKVTGNLTIRDITREVVLDAEQLGGAKDPWGNVKTAFEAKTSVDRRDFGLTWNQALEAGGVLVGEKIEIAIEVQAVKAQAEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4X0</accession>
    <name>Q1D4X0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase, unclassified family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4128"/>
    <dbReference type="EnsemblBacteria" id="ABF88118">
        <property type="protein sequence ID" value="ABF88118"/>
        <property type="gene ID" value="MXAN_4128"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4128"/>
    <dbReference type="eggNOG" id="COG2433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039294_0_1_7"/>
    <dbReference type="OMA" id="PEITRYN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045618">
        <property type="entry name" value="DUF6444"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20042">
        <property type="entry name" value="DUF6444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6444" evidence="4">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="zf-IS66" evidence="3">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="159"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="468" mass="51667" checksum="5AFEC3CA96FC920F" modified="2006-07-11" version="1">MGHGTHPVVAEVDPKDARIAELERQVEELTRLVQELREQLRRDSGNSNRPPSSDTPGQKAVRRRQSGSEKKRGGQPGHVGLTRALVAEEKVSEFKHLFPSACGNCWAPLSPEGGTRVRRYQSVELPPLKAHVTQWMRHGVECPRCKHETWASTAAIPTSAFGPRLSAVVGLLTGVYHLSRRSAVRLLGDVLGIDISLGAVSAVEARVSEAVKPAVDEAWSRVLLAPVKHTDGTQWLEAGLARTLWTIASSMATVFKILADSKSRTLAPLFGQKLGVLVSDRATALNFWAMEARQVCWAHLLRKAVSFSERDGPAGAIGRELLDYIGILFDYWGRLRSGELQRDTLRERMASVRTQVEALLERAVAARLPHVSGSCEDILQHRAALWTFVDREGVEPTNNHAERELRAFVLWRKRSFGTQSPRGNLFAERVMTVAHTARKQEKNVLEFLTACCTAARTGMPAPSLFAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D588</accession>
    <name>Q1D588_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4005"/>
    <dbReference type="EnsemblBacteria" id="ABF88593">
        <property type="protein sequence ID" value="ABF88593"/>
        <property type="gene ID" value="MXAN_4005"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4005"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071992_0_0_7"/>
    <dbReference type="OMA" id="LYWHLRY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="314" mass="34889" checksum="FD341C7688D7507F" modified="2006-07-11" version="1">MLEGDSVQARHRLERFPVNVGRGYGNDVILDDPKVSAEHLRIERREDGTLVLRDVGSQNGTYRVEPWAQLAELELATDIRVSVGDTVLRFRARGHPVEKTVVAAAPTAPRPRVFEQPRYFSLALQALLGASLLEGYLANYGRTDWGELTVALVVPLGITFLWAGGWSVASRIARRQFHYRTHATVAALVLLGSVVIQPLLTLVGFSLGVSGNLAWAHHVAFLSLMAWGLYWHLRYVTRWEPGRLIRVIAVVTLSFGALSRADAWLGNESFSTELGFRRSLLPPVFRLVGTEPLDDFFSDAVKVQEQVDALARDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5D6</accession>
    <name>Q1D5D6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553967.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3957"/>
    <dbReference type="EnsemblBacteria" id="ABF91029">
        <property type="protein sequence ID" value="ABF91029"/>
        <property type="gene ID" value="MXAN_3957"/>
    </dbReference>
    <dbReference type="GeneID" id="41361289"/>
    <dbReference type="KEGG" id="mxa:MXAN_3957"/>
    <dbReference type="eggNOG" id="ENOG502ZC40">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893447_0_0_7"/>
    <dbReference type="OMA" id="AAPKYIY"/>
    <dbReference type="OrthoDB" id="1408882at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188254" evidence="1">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32522" checksum="97EBE11E38BF0459" modified="2006-07-11" version="1">MRVLPLLLLALTPGCASTLSTQQTARTLAPGQVQVTGGVGAFVPVGALVRVVDAGIEQGEAARDAVVNDRPYTLSEEDQQELLTAGVALMVAPPGVNPELMVRVGVVDRLDVGLRYSGISLRGDLKFQLAHGGDEVGRYLELGQRSFDMALGVGVSKHFFSSPVLDVLEVVEMNDFSRYDVEVPLYLSADWGDVFKLYAAPKYIYSRTRLDARLVDYSQQGKPVSGFDARLPATVGSHFVGSTLGIAVGYRYVHLFAEVTGGYFRSRPQLFGMERNLGGVTVMPSVGLAIRAGGSDRKPTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5D9</accession>
    <name>Q1D5D9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553964.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3954"/>
    <dbReference type="EnsemblBacteria" id="ABF91101">
        <property type="protein sequence ID" value="ABF91101"/>
        <property type="gene ID" value="MXAN_3954"/>
    </dbReference>
    <dbReference type="GeneID" id="41361286"/>
    <dbReference type="KEGG" id="mxa:MXAN_3954"/>
    <dbReference type="HOGENOM" id="CLU_979445_0_0_7"/>
    <dbReference type="OMA" id="ALSWERV"/>
    <dbReference type="OrthoDB" id="1325939at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="31066" checksum="B34952DF3A4C1350" modified="2006-07-11" version="1">MELWRMALTPVYAACLLGLLVVAFAYGRKDVTSRPYRVPLLWFGLLAGVSLVVLRHVQGTGAVLASETAVKAMGSVLLMLAAGLALRGAWARTRANVLRGSAPVPLDEAVEALRAGASPGWGVYHGVLDAESTLTSPGGVPCVFFDAEVREVAADGRRGPLLSRERAYAPVLALRGQRLHASVSFSPASLMAPVEVRRCKALPGTVPASWYQTAHPEALSWERVGAVGESCLVVGELRRGPVEGSYALVGREGGPAMLVLGPQAPATCGTLARRAWRHFAAAGVLSMAAAVVLSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5F5</accession>
    <name>Q1D5F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553948.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3938"/>
    <dbReference type="EnsemblBacteria" id="ABF89568">
        <property type="protein sequence ID" value="ABF89568"/>
        <property type="gene ID" value="MXAN_3938"/>
    </dbReference>
    <dbReference type="GeneID" id="41361270"/>
    <dbReference type="KEGG" id="mxa:MXAN_3938"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232553_0_0_7"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="515"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="738"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2007"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2088" mass="228971" checksum="9D60763F2B1F1786" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5G8</accession>
    <name>Q1D5G8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3925"/>
    <dbReference type="EnsemblBacteria" id="ABF92638">
        <property type="protein sequence ID" value="ABF92638"/>
        <property type="gene ID" value="MXAN_3925"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3925"/>
    <dbReference type="eggNOG" id="COG2303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008878_4_1_7"/>
    <dbReference type="OMA" id="WEQAPLA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="58190" checksum="CA388C1EB54B6937" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5P8</accession>
    <name>Q1D5P8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553855.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87340">
        <property type="protein sequence ID" value="ABF87340"/>
        <property type="gene ID" value="MXAN_3843"/>
    </dbReference>
    <dbReference type="GeneID" id="41361176"/>
    <dbReference type="KEGG" id="mxa:MXAN_3843"/>
    <dbReference type="HOGENOM" id="CLU_711541_0_0_7"/>
    <dbReference type="OMA" id="PEAHALY"/>
    <dbReference type="OrthoDB" id="428318at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="390" mass="42912" checksum="792C0F1FE16BA7DF" modified="2006-07-11" version="1">MEPFNGSLANYRLQLVMPPLFSAPGVEGVLSVERGAVRRCFHVKDGYLVGESSNDPREHLAQILVNLRILDAPRAAAAFEAAEGAGMPYGTFLVQRCFVELPRLIEALEHKARESLFDCYAWESGEVGFTPGLPPSARAIGLKLSLSTLHRDAVSRQREWSMFRDIFPRMDTTFRVFREFAVETYSEEEDVLLDLAASGATLGELLASAREAPLFAARWVLHLYRRGALAPRKALGPRLGEAAELEELLTLVKRFLEAGQYDHAVALAAQILEQGPVPEAHALYREAEIRLTLALSDELFALDGRLVFEPIPRPTPPDLTADDLYLYSKLRGSRSIRQALRTAAMGELAASRSVHRLMASGLIRVAPLPGSGPRRAHTDPFGLPIHGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5R4</accession>
    <name>Q1D5R4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3827"/>
    <dbReference type="EnsemblBacteria" id="ABF88037">
        <property type="protein sequence ID" value="ABF88037"/>
        <property type="gene ID" value="MXAN_3827"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3827"/>
    <dbReference type="eggNOG" id="COG2960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044709_0_0_7"/>
    <dbReference type="OMA" id="DNGYACV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011447">
        <property type="entry name" value="DUF1552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07586">
        <property type="entry name" value="HXXSHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="508" mass="55039" checksum="FC593FD24CE218D6" modified="2006-07-11" version="1">MWGRAPRRALGNPRGLQLSGIPGAFRGGTLVAEQCGGSDNKDPPVPKSRTWELSRRSLLRGAAGAALALPWLEAMAPSTARAQASGAKPPLRFVGMFHSAGVVPNQWFPTTEGANYALTPTLSPLAPVKDDVLVLSGMRLGAWDYYERTHEGGFWMMLTASERIVAGSTDSIDQVIARATSAQVRVPALTLSVENNGYYNPGYRDANGDGFIDPKTSSYDDTQDHCSGEDHCMVTFSRGRRLPNVYNPRVIFDRLFGSLPAEGPTDAERRLWMYRRSVLDRMTGQAKALQAKVGQADKLRLDEYLTGIREIEVAIQKAEQGAPAAACTTGARPVGIPMDGTAYANLMCDLIVKSFECDATRVATLMLGMCVSPMMFTVNGRAFSHHGDASHHGNDPVKLAAKVEIDRWQVARFAHLVQRLKAVPEGEGTLLDNVAVFYSSDISHSDWHNHYDMPVLLAGRAGGAIRPGRHMRAQGKRCGDVLLSILQAFEIPRGTFGPLAQGPLAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U0</accession>
    <name>Q1D5U0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553813.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3801"/>
    <dbReference type="EnsemblBacteria" id="ABF88576">
        <property type="protein sequence ID" value="ABF88576"/>
        <property type="gene ID" value="MXAN_3801"/>
    </dbReference>
    <dbReference type="GeneID" id="41361132"/>
    <dbReference type="KEGG" id="mxa:MXAN_3801"/>
    <dbReference type="HOGENOM" id="CLU_1766045_0_0_7"/>
    <dbReference type="OMA" id="LYLWQVT"/>
    <dbReference type="OrthoDB" id="1783230at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="147" mass="16107" checksum="1E6C839A5772FEB0" modified="2006-07-11" version="1">MADTPPPAESPSSAAPPPRPNERKSALAKRLPLLLLVALGLYLWQVTGTPERDVAFQLAGPGWASVRAVDLQISDPEGQLIKREERFFPSGPPPELTYKVDLPEGTWDASLFVKREGTDARVRLETELVVGEGQYIVQQLQLPAAVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D772</accession>
    <name>RL2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">MXAN_3302</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553343.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D772"/>
    <dbReference type="SMR" id="Q1D772"/>
    <dbReference type="STRING" id="246197.MXAN_3302"/>
    <dbReference type="EnsemblBacteria" id="ABF88953">
        <property type="protein sequence ID" value="ABF88953"/>
        <property type="gene ID" value="MXAN_3302"/>
    </dbReference>
    <dbReference type="GeneID" id="41360655"/>
    <dbReference type="KEGG" id="mxa:MXAN_3302"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_7"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000309965" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="281" mass="30630" checksum="F44F287381AF4CCC" modified="2006-07-11" version="1">MGIKKYKPTSAARRLMTVSDFADITKDSPEKSLTEPLKRSGGRNVHGHITRRHQGGGHKRRYRVIDFKRRDKDGVPAKVVAVEYDPNRTANIALLHYADGEKRYILAPVGLSVGDTVFAGEGADIRPGNSLPLQNIPVGTVIHNVELKPGRGAQVIRSAGTSGQLMAKEDRYAQVRMPSGTVRKVLIECRATVGQVGNIEHEIIRIGKAGKSRWLGIRPTVRGLAMNPVDHPHGGGEGKSGQGNPHPVSPWGKKTKGLTTRTNKRTDKFIVSGRRQGARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E5</accession>
    <name>Q1D7E5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bacterial sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553274.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3229"/>
    <dbReference type="EnsemblBacteria" id="ABF88433">
        <property type="protein sequence ID" value="ABF88433"/>
        <property type="gene ID" value="MXAN_3229"/>
    </dbReference>
    <dbReference type="GeneID" id="41360583"/>
    <dbReference type="KEGG" id="mxa:MXAN_3229"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_0_0_7"/>
    <dbReference type="OMA" id="WAQIRYP"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187957" evidence="8">
        <location>
            <begin position="28"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="9">
        <location>
            <begin position="267"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="50156" checksum="28F313AA2E1AB2D7" modified="2006-07-11" version="1">MLRVFHHYFSAKKLTFFLAESSAIALACVMGAAACAALFAPEGTHTPLSQLWPTLLWMGAAFVITFQFTLYLLDLYDLRVAAEDRVRGYRFLKAAGVTAMVAGGVMLVTPLVVPMQLPPGTLLGGAMGALAGTLMVRVSIRALVGAPHSVLIVGEGPKARAVASAIDAGGEGTYRIVGLTDPRTSGEALEETAARLNAAYVVQAADDMRGANWVDGLLRCRLQGRRVYEATGFCERVLRRIPVQFLRASDFAFADELTVSPLRRTLKRGFDIAVASLLLMLSAPFLLLVVVAIKLDSKGPIFYRQERTGLFGSTYHLWKFRSMRTDAEKHGAVWAKANDDRVTRVGRFIRRARIDEIPQVFNILTGDMSFVGPRPERPVFVEQLKEQIPFYGLREAVKPGLTGWAQIRYPYGASVEDARNKLEFDLYYVKNGSLFLDVGIIFHTVRHVLLGRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7W6</accession>
    <name>Q1D7W6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553104.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3049"/>
    <dbReference type="EnsemblBacteria" id="ABF87395">
        <property type="protein sequence ID" value="ABF87395"/>
        <property type="gene ID" value="MXAN_3049"/>
    </dbReference>
    <dbReference type="GeneID" id="41360411"/>
    <dbReference type="KEGG" id="mxa:MXAN_3049"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2082253_0_0_7"/>
    <dbReference type="OMA" id="VCRLLRM"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="14750" checksum="38E10E77645F3D81" modified="2006-07-11" version="1">MELWVTRRDPAEVTVEPIIVCAELYMRLGDDEVLVLDCRDAADWERYDLHIPGALRMTSAEIARDHHMLPDDELIVLCGCSPDGRDARRVCRLLRMKGREAVCLDGGLLAWVTGGFPTERHTRAPVAAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Y9</accession>
    <name>Q1D7Y9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553081.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3025"/>
    <dbReference type="EnsemblBacteria" id="ABF87539">
        <property type="protein sequence ID" value="ABF87539"/>
        <property type="gene ID" value="MXAN_3025"/>
    </dbReference>
    <dbReference type="GeneID" id="41360386"/>
    <dbReference type="KEGG" id="mxa:MXAN_3025"/>
    <dbReference type="eggNOG" id="ENOG5030WK3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033811_1_0_7"/>
    <dbReference type="OMA" id="AVRWEIP"/>
    <dbReference type="OrthoDB" id="568037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045750">
        <property type="entry name" value="DUF6178"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19676">
        <property type="entry name" value="DUF6178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="571" mass="62514" checksum="97E324653E46B47C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D832</accession>
    <name>Q1D832_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2982"/>
    <dbReference type="EnsemblBacteria" id="ABF89379">
        <property type="protein sequence ID" value="ABF89379"/>
        <property type="gene ID" value="MXAN_2982"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2982"/>
    <dbReference type="HOGENOM" id="CLU_3218988_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="44" mass="4394" checksum="3A5E6E9C8C67FE52" modified="2006-07-11" version="1">MLLSAARPAGREAADVFLAKPVAVPTLPEPNAPHGHAQGALPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8I3</accession>
    <name>Q1D8I3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2829"/>
    <dbReference type="EnsemblBacteria" id="ABF89874">
        <property type="protein sequence ID" value="ABF89874"/>
        <property type="gene ID" value="MXAN_2829"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2829"/>
    <dbReference type="HOGENOM" id="CLU_2130757_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="11711" checksum="772ADB7E218243B1" modified="2006-07-11" version="1">MAVAADAFGHVEAGGEAGVGPRRGSVRGQWADAEGVLRSARRAAEHIAVVGVPARRQRGSQAAPVRLLPVEVAGMSRPSTVLLEVVTASGARVRFSVGTDVEYVARLVAELGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K2</accession>
    <name>SYM_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="ordered locus">MXAN_2804</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552871.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8K2"/>
    <dbReference type="SMR" id="Q1D8K2"/>
    <dbReference type="STRING" id="246197.MXAN_2804"/>
    <dbReference type="EnsemblBacteria" id="ABF91901">
        <property type="protein sequence ID" value="ABF91901"/>
        <property type="gene ID" value="MXAN_2804"/>
    </dbReference>
    <dbReference type="GeneID" id="41360180"/>
    <dbReference type="KEGG" id="mxa:MXAN_2804"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_7_0_7"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000331852" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="602"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="703" mass="77332" checksum="762524BF00AE01CA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q4</accession>
    <name>Q1D8Q4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GYF_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552819.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2752"/>
    <dbReference type="EnsemblBacteria" id="ABF90371">
        <property type="protein sequence ID" value="ABF90371"/>
        <property type="gene ID" value="MXAN_2752"/>
    </dbReference>
    <dbReference type="GeneID" id="41360129"/>
    <dbReference type="KEGG" id="mxa:MXAN_2752"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412686_0_0_7"/>
    <dbReference type="OMA" id="LCWREGF"/>
    <dbReference type="OrthoDB" id="851505at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
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        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GYF_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="654" mass="66618" checksum="CB2175726482AC99" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8S2</accession>
    <name>NUOA_MYXXD</name>
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        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoA</name>
        <name type="ordered locus">MXAN_2734</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552801.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D8S2"/>
    <dbReference type="SMR" id="Q1D8S2"/>
    <dbReference type="STRING" id="246197.MXAN_2734"/>
    <dbReference type="EnsemblBacteria" id="ABF91635">
        <property type="protein sequence ID" value="ABF91635"/>
        <property type="gene ID" value="MXAN_2734"/>
    </dbReference>
    <dbReference type="GeneID" id="41360111"/>
    <dbReference type="KEGG" id="mxa:MXAN_2734"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_0_2_7"/>
    <dbReference type="OMA" id="RFPVKYY"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
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        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
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    </dbReference>
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    </dbReference>
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    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000362704" description="NADH-quinone oxidoreductase subunit A">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <sequence length="123" mass="13586" checksum="0D891D248D92CC03" modified="2006-07-11" version="1">MTPTPLTPYLPLAVVLLLAGGMAMLIPQITTRLGPRRPSAIKATSFEAGSESSGPARQRFAVKFYVVALLFIVFDVEAVFLYPWAVNFQALGWFGYVEMLVFAVTLVVGLIYIWKKGALDWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D982</accession>
    <name>Q1D982_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole-5'-phosphate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC</name>
        <name evidence="1" type="ORF">MXAN_2572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.73" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552642.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2572"/>
    <dbReference type="EnsemblBacteria" id="ABF86304">
        <property type="protein sequence ID" value="ABF86304"/>
        <property type="gene ID" value="MXAN_2572"/>
    </dbReference>
    <dbReference type="GeneID" id="41359950"/>
    <dbReference type="KEGG" id="mxa:MXAN_2572"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_7"/>
    <dbReference type="OMA" id="TRHGKTE"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="23195" checksum="E48D42E85C67F81E" modified="2006-07-11" version="1">MTTEFILLRHGETEWNSLGRLQGHQDSTLSQVGLRQADALAARLEPVRFSALYCSDLGRAQETARRIAIRTGHTVQSDTRLRERGLGILEGLTRDEARQKHPDVFAAYAGGAPDYIVPGGESTSQRLRHAVECLEELGARHRGERLVVVTHGGVLSLLFRHSLGIPHAAPRTFSVLNAGWNQFDYHEGAWRLVTWGDVTHLRASSLDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9B5</accession>
    <name>Q1D9B5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552609.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2539"/>
    <dbReference type="EnsemblBacteria" id="ABF91576">
        <property type="protein sequence ID" value="ABF91576"/>
        <property type="gene ID" value="MXAN_2539"/>
    </dbReference>
    <dbReference type="GeneID" id="41359917"/>
    <dbReference type="KEGG" id="mxa:MXAN_2539"/>
    <dbReference type="eggNOG" id="ENOG502ZE9Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975358_0_0_7"/>
    <dbReference type="OMA" id="WSPIYGK"/>
    <dbReference type="OrthoDB" id="1074765at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030820">
        <property type="entry name" value="OMP_myx_plus_Proteobacteria"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04565">
        <property type="entry name" value="OMP_myx_plus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188517" evidence="2">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29502" checksum="DFCB21ACBD37B182" modified="2006-07-11" version="1">MNRPKLLLALCLVPALASAQSQEGMGLDLTDESQAESSQDAESPAPPPMEEATPAAASRPADEPLEADPQLPLTDITQEDRVKSVQRKVYLKKGRFELTPLVSLSVNDPFYSKVGLSVRGAYYLADTLAVSARASLMQVVPSDDVRTAKRTFNSKIYYSVPQWSAMGDVEWSPIYGKVAFLNSILHFDGYLLAGAGVVNTETSALPGRGLNPAADLGLGMRFVAQDYIAVNVALINTSYVDQPLGSSKGAIQNVMTLNAGISLFLPFKSTGRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9F0</accession>
    <name>Q1D9F0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative general secretion pathway protein L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552575.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2504"/>
    <dbReference type="EnsemblBacteria" id="ABF90237">
        <property type="protein sequence ID" value="ABF90237"/>
        <property type="gene ID" value="MXAN_2504"/>
    </dbReference>
    <dbReference type="GeneID" id="41359882"/>
    <dbReference type="KEGG" id="mxa:MXAN_2504"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515494_0_0_7"/>
    <dbReference type="OMA" id="VDIGHER"/>
    <dbReference type="OrthoDB" id="388445at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="533" mass="57215" checksum="CA689039FFB353BD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H6</accession>
    <name>Q1D9H6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552549.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2477"/>
    <dbReference type="EnsemblBacteria" id="ABF86054">
        <property type="protein sequence ID" value="ABF86054"/>
        <property type="gene ID" value="MXAN_2477"/>
    </dbReference>
    <dbReference type="GeneID" id="41359860"/>
    <dbReference type="KEGG" id="mxa:MXAN_2477"/>
    <dbReference type="eggNOG" id="ENOG5033I4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434650_0_0_7"/>
    <dbReference type="OMA" id="RFDFAWY"/>
    <dbReference type="OrthoDB" id="523858at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="552"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="635" mass="68535" checksum="CC5D4E04EA74B468" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA41</accession>
    <name>Q1DA41_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="5">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="5">ICM</shortName>
                <ecNumber evidence="5">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">P-loop GTPase</fullName>
                <ecNumber evidence="5">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="5">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">icmF</name>
        <name evidence="7" type="ORF">MXAN_2261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="5"/>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552337.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2261"/>
    <dbReference type="EnsemblBacteria" id="ABF90102">
        <property type="protein sequence ID" value="ABF90102"/>
        <property type="gene ID" value="MXAN_2261"/>
    </dbReference>
    <dbReference type="GeneID" id="41359649"/>
    <dbReference type="KEGG" id="mxa:MXAN_2261"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_2_0_7"/>
    <dbReference type="OMA" id="LAMFMNT"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4 5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
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</entry>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Sullivan S.A."/>
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    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26557" checksum="292EEBA663AA72AF" modified="2006-07-11" version="1">MRPGEQLTVVLHQTRSTDNLGAVARIMANFGYSRLILSEPVLKSIEGAERLAVKSDFVLRGMEVTSDLGEALKDCVYAVGTTSRTQLKGRTVLTPEEAMQRLAEESVRGRVALVFGGEQRGMSDEDLARCTDVLAIPTSAVQPSMNLAQSSAVLLYLCHRQGLTPTAAVEEAPGAKLGTLGALAKRMRDVMLRAEFLNPQAPQHVLNELEQTLMRARLTQREAELWLTAFKHLERAVTRGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR9</accession>
    <name>Q1DAR9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2914 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552109.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2025"/>
    <dbReference type="EnsemblBacteria" id="ABF88925">
        <property type="protein sequence ID" value="ABF88925"/>
        <property type="gene ID" value="MXAN_2025"/>
    </dbReference>
    <dbReference type="GeneID" id="41359435"/>
    <dbReference type="KEGG" id="mxa:MXAN_2025"/>
    <dbReference type="eggNOG" id="ENOG5032CBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051181_0_0_7"/>
    <dbReference type="OMA" id="KVWRWRE"/>
    <dbReference type="OrthoDB" id="1196888at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022606">
        <property type="entry name" value="DUF2914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11141">
        <property type="entry name" value="DUF2914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2914" evidence="3">
        <location>
            <begin position="350"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="466" mass="51776" checksum="88440AE3723CFE3F" modified="2006-07-11" version="1">MVTATRHNAPENPDEASAEVPNAGPAVEASVPVAENHAAVALTDAVLPAQAPGVVVDPDDLVDTAKTPTLMDKVQQFRARHEKWEMAVFFFGGFIYDVLTISRIDDTLTLAQNFGYLLVLTGLLLLEQRYPDGVEPPKFLQKVWRWREDGIHFLFGSLLSAFMLLLFKSTSGALPYLFVVGLFALLAANELPLFRRLGPIMRMVLLSLCVTMYFVCLLPVVLGRMGFWVFLLAVAMGCASIFGVMRLIRRWRPDNRYLLRNVAIPGFGVQAALLGLYLVGVIPPLPVAVQFAGIYHQVERVSPGIYHLSSVDSGAWYKPWTWGGPDFLMQPGDKPYYFFRIFAPKHFQSYKVRVRWYFDDPQKGWTTYGNGFMATVSSNGTDGGYRFYATTSNLKPGKWRVVLETEAGHEIHRLNFTAGPDANPGPRVYEVAVSTLKDVKPLALSEWQERAAAAAAKPATAAPKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY4</accession>
    <name>Q1DAY4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552044.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1951"/>
    <dbReference type="EnsemblBacteria" id="ABF92620">
        <property type="protein sequence ID" value="ABF92620"/>
        <property type="gene ID" value="MXAN_1951"/>
    </dbReference>
    <dbReference type="GeneID" id="41359364"/>
    <dbReference type="KEGG" id="mxa:MXAN_1951"/>
    <dbReference type="HOGENOM" id="CLU_2586024_0_0_7"/>
    <dbReference type="OMA" id="QACTVER"/>
    <dbReference type="OrthoDB" id="1999836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="83" mass="8992" checksum="637F92EEB3CF5AA2" modified="2006-07-11" version="1">MVSMVGLWGAVQVELLEDVRAQVVRLDTGQACTVERASLPKGAREGDVVVDGRLEPGQTEARRQDVARMRTRLAVPVPPGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF4</accession>
    <name>Q1DBF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551878.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1769"/>
    <dbReference type="EnsemblBacteria" id="ABF90571">
        <property type="protein sequence ID" value="ABF90571"/>
        <property type="gene ID" value="MXAN_1769"/>
    </dbReference>
    <dbReference type="GeneID" id="41359195"/>
    <dbReference type="KEGG" id="mxa:MXAN_1769"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045651_0_0_7"/>
    <dbReference type="OMA" id="YLKGHIM"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039439">
        <property type="entry name" value="SH3b1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12913">
        <property type="entry name" value="SH3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188102" evidence="2">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="SH3_6" evidence="4">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="317"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="459" mass="49907" checksum="C6B37142D537EB2D" modified="2006-07-11" version="1">MRILSLAVMGTTACAAPSALAVSPAGVPAFSEDMLSPEFWIRRAPSPDEVLLDADQVAAKRMRAFGPDGGLVDLKRIPATLTRAEVASWVKDAQQTPIQAAIDEQGRLVTEAMLEELRQNTAAEHIPEASTARYGLSVRRTPLRSLPSERRFFAAENLRDYESLQAGILFPGEPVVIAHHSADQQWLFVLTTQGPAWVRRGDVAEGTADTVFSYVAKAPGRVVTGDQVRTVFTPEAPGVSELELDMGVALPRADVAPGEPVNGASSYASWPVLLPVREQDGTLAFQSALLRRTADTAPGYLPLTRANILRQAFKFLGERYGWGHQFNARDCSGLTSEVYRSLGLFLPPNSGMQGKSAALNHRLFTAQDSHTERLRALARAQVGDLIVVPGHVLMLIGHVNGEPYVIQDVPYAVFKDPATQQLRKTKLNQVSVTPLLPLYADDTTLYVDAMTSLVHVTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ4</accession>
    <name>Q1DBQ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551778.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1667"/>
    <dbReference type="EnsemblBacteria" id="ABF88568">
        <property type="protein sequence ID" value="ABF88568"/>
        <property type="gene ID" value="MXAN_1667"/>
    </dbReference>
    <dbReference type="GeneID" id="41359107"/>
    <dbReference type="KEGG" id="mxa:MXAN_1667"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_7"/>
    <dbReference type="OMA" id="QAKDFFH"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="259"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="373" mass="39312" checksum="4F581A2D265DA1DB" modified="2006-07-11" version="1">MWMGACLDDAGSPSSAASGEIDNERAILATVITHVVFDGVAEGSLGVGLDVVDTAARLVEAGLASVPRGAQVLRQRVVSLDGQPVRSGTGRTVSVDGALSLRSVKAGDVLLVPGLSAASERAIEQLLSRADAARGITLLARVAAKGAMVAASCSATFVLAASGLLAGRSATTTWWLVPSFVRRFPEVALQPDRMVVESDGVLTAGSAFAHADLVLAIVARVASPSLAHLVARYLVLDERVSQARYMVMEHLRVSDPALRAVEQFVAANLGRQLTLDELARAGATSSRTLARRVQAGLGMTPLEFVQRVRVAHASHLLETTHASVEDVAARVGYADTAAFRRVFRRYVGETPRGRRGNSRSRRSPLNARDSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBV4</accession>
    <name>Q1DBV4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein CspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cspA</name>
        <name evidence="4" type="ORF">MXAN_1617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551728.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DBV4"/>
    <dbReference type="STRING" id="246197.MXAN_1617"/>
    <dbReference type="EnsemblBacteria" id="ABF92177">
        <property type="protein sequence ID" value="ABF92177"/>
        <property type="gene ID" value="MXAN_1617"/>
    </dbReference>
    <dbReference type="GeneID" id="41359061"/>
    <dbReference type="KEGG" id="mxa:MXAN_1617"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_7"/>
    <dbReference type="OMA" id="ICEMAKI"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="68" mass="7357" checksum="C88DC4269ACBC014" modified="2006-07-11" version="1">MATGTVKWFNDAKGFGFIAQDDGGADVFCHHTAIQTDGFRTLAEGQKVEFETRKGPKGLQAENVRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ0</accession>
    <name>Q1DBZ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551692.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="TCDB" id="2.A.86.2.2">
        <property type="family name" value="the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9,b,22)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90043">
        <property type="protein sequence ID" value="ABF90043"/>
        <property type="gene ID" value="MXAN_1581"/>
    </dbReference>
    <dbReference type="GeneID" id="41359026"/>
    <dbReference type="KEGG" id="mxa:MXAN_1581"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_1_7"/>
    <dbReference type="OMA" id="VGMKLVY"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="41697" checksum="A37B21A6B2077985" modified="2006-07-11" version="1">MATEQTARRVFTGLIILSIILLALVVRPFAKAFFLAAVLAGTFYGLYSRLSRKLRGHNNLAAGVIVSGVILALLLPLGGLTAFIVTEVSDGVKFVSDTVQREGVEGLIGKIPSPVRGPVERLLERIPLEQAQLDETLQQQVSTQGGTAARAVTGAVAATGSIAFQTVMMLIALFFLLTEGARLVSWVESVSPLRRGQTREILREFRSVSVAVLVSSVATAGVQAAAALVGFLIARVPAALFFAGVAFFMALIPAVGAAIVVLVAAALMFFSGHPWAALFLAIWGTVVVGLVDNIVKPLLARRGMHQHAAIVFFALLGGLAAFGTVGLLLGPLIVAFFLALLRIYERDYGRPTPRPGDPATPGGPSGDESLIIRPSVLSAETRERVPLSPTPPENH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC96</accession>
    <name>RL27_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">MXAN_1470</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551586.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DC96"/>
    <dbReference type="SMR" id="Q1DC96"/>
    <dbReference type="STRING" id="246197.MXAN_1470"/>
    <dbReference type="EnsemblBacteria" id="ABF87598">
        <property type="protein sequence ID" value="ABF87598"/>
        <property type="gene ID" value="MXAN_1470"/>
    </dbReference>
    <dbReference type="GeneID" id="41358916"/>
    <dbReference type="KEGG" id="mxa:MXAN_1470"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_7"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000017526" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="91" mass="9722" checksum="1F09F3A4C5DC282C" modified="2006-07-11" version="1">MAHKKGQGSSRNGRDSNPQYRGVKVYGGETVSAGSILVRQVGTVIHAGANVKLGRDFTLYSVVDGVVKYERLGRDRKKVSVYPAAAEQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCA5</accession>
    <name>Q1DCA5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1461"/>
    <dbReference type="EnsemblBacteria" id="ABF86293">
        <property type="protein sequence ID" value="ABF86293"/>
        <property type="gene ID" value="MXAN_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1461"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195342_0_0_7"/>
    <dbReference type="OMA" id="CGMDLQT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="13141" checksum="906A5EF9628B1779" modified="2006-07-11" version="1">MEEHHMADARTDKPSSTEEEYFAREEIEKKRKLALEQAAASAAQQREELKKLHWMKCPKCGMDLQTLKQGNVEIETCFNCHGIFLDAGELDQLVAQHGHEGSGKVMGAILNLFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCF2</accession>
    <name>Q1DCF2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551531.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1414"/>
    <dbReference type="EnsemblBacteria" id="ABF92510">
        <property type="protein sequence ID" value="ABF92510"/>
        <property type="gene ID" value="MXAN_1414"/>
    </dbReference>
    <dbReference type="GeneID" id="41358860"/>
    <dbReference type="KEGG" id="mxa:MXAN_1414"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="QIVDRMA"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="279"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="337"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="609" mass="63498" checksum="240587CE57388054" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT1</accession>
    <name>Q1DCT1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tryptophan halogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1285"/>
    <dbReference type="EnsemblBacteria" id="ABF90647">
        <property type="protein sequence ID" value="ABF90647"/>
        <property type="gene ID" value="MXAN_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1285"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466825_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="604" mass="68459" checksum="3720B27D0B723DF7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD59</accession>
    <name>Q1DD59_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">MXAN_1154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551274.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1154"/>
    <dbReference type="EnsemblBacteria" id="ABF91019">
        <property type="protein sequence ID" value="ABF91019"/>
        <property type="gene ID" value="MXAN_1154"/>
    </dbReference>
    <dbReference type="GeneID" id="41358605"/>
    <dbReference type="KEGG" id="mxa:MXAN_1154"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_7"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="262" mass="28260" checksum="2CDCF7ABAF09AB73" modified="2006-07-11" version="1">MALLTVRNLHARVAGKDILKGIDLEVAPGEVHAIMGPNGSGKSTLASVLAGRDGYEVTQGEVLFDGKPLLELSPEARAAAGVFLAFQYPVEIPGVGNIHFLRTALNAQRRAKGLEELDAMDFLQLAKEKSKLVQLDAAFMNRSVNEGFSGGEKKRNEIFQMAVLEPRLAILDETDSGLDIDALRTVAGGVNALRSPERGMVLITHYQRLLDYIVPDKVHVIAAGRIVRSGGRELALELEEKGYGWLGLDGGKAKAPVAEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDA5</accession>
    <name>Q1DDA5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1108"/>
    <dbReference type="EnsemblBacteria" id="ABF89726">
        <property type="protein sequence ID" value="ABF89726"/>
        <property type="gene ID" value="MXAN_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1108"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_1_7"/>
    <dbReference type="OMA" id="YAYGFIM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="25742" checksum="DAFAB087B3A814BE" modified="2006-07-11" version="1">MDVSALHLILLCVAALIAGMVDAIAGGGGLISLPALLAAGLPPHVALGTNKGQSVFGSFAALVRFSRAGLVDGNLARVTFPFGLGGAFGGAALVLLVKPEVLKPLVLVLLIAVAVFLAFRKSPRPGDMPEPGPPARARAIGALIALAIGTYDGFFGPGTGTFLIVAFSSLLGHGLARASADAKVVNFASNLASVALFAFKGVVLWKVALPMAGAQFAGAYLGAHLAVKGGDKLVRKVVLGVVLALVLKLGHDVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDG6</accession>
    <name>Q1DDG6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat/HVR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1046"/>
    <dbReference type="EnsemblBacteria" id="ABF86867">
        <property type="protein sequence ID" value="ABF86867"/>
        <property type="gene ID" value="MXAN_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1046"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309921_0_0_7"/>
    <dbReference type="OMA" id="RAIYRHD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="649"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="878" mass="91679" checksum="6E7FEF43120BF0F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDK5</accession>
    <name>Q1DDK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551128.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1007"/>
    <dbReference type="EnsemblBacteria" id="ABF87077">
        <property type="protein sequence ID" value="ABF87077"/>
        <property type="gene ID" value="MXAN_1007"/>
    </dbReference>
    <dbReference type="GeneID" id="41358462"/>
    <dbReference type="KEGG" id="mxa:MXAN_1007"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162754_0_0_7"/>
    <dbReference type="OMA" id="KQWRSDA"/>
    <dbReference type="OrthoDB" id="1844907at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="103" mass="11292" checksum="535A919137DE2567" modified="2006-07-11" version="1">MGAEALGWFSSFVLLLTIAVQVHKQWKSGSSEGVSKWLFVGQMTASVGFTLYSWKVGNWVFVVTNALMLLSAVLGAVIVLKHRRVARRKHATQPRAPSDAVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM5</accession>
    <name>Q1DDM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0987"/>
    <dbReference type="EnsemblBacteria" id="ABF87137">
        <property type="protein sequence ID" value="ABF87137"/>
        <property type="gene ID" value="MXAN_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0987"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178631_0_0_7"/>
    <dbReference type="OMA" id="SAHYMVD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="22016" checksum="4858D4BC3BF238E0" modified="2006-07-11" version="1">MKKFQADNKLPTTGFYGDLTQAALKKALGTSGPTTPTTPGGKFTKPAVINAPSPNQNSRGGTKIDTIVMHHTATNNGAGDLSWMRNPQSKVSAHYMVDRDGKIYQLVGDDKRAWHAGKGELHGVPSDINNRSIGIEIVNDGSGKTPFTEAQYKSLTQLTGYLKQQHNIPMKNIVGHADVAVPKGRKNDPAPNFDWNRLRKGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP7</accession>
    <name>Q1DDP7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551086.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0965"/>
    <dbReference type="EnsemblBacteria" id="ABF86011">
        <property type="protein sequence ID" value="ABF86011"/>
        <property type="gene ID" value="MXAN_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="41358423"/>
    <dbReference type="KEGG" id="mxa:MXAN_0965"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_1_1_7"/>
    <dbReference type="OMA" id="RMAPMHW"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="80"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="34284" checksum="1068F7CE70CE6815" modified="2006-07-11" version="1">MALRFKNLDGSGPQPFSSIFKWAVADKLAGRRRKAPARAEVPRVEPDLALLATPPATGEGARLTWLGHASWLVQLDGLSLLIDPVLRDAISGVIRRNVPPGVPLEKLPPITASLVSHNHYDHLDLPTLEKVGAPIVTGLGHAPVFRGSGLGVTELDWWRSTQVGAVTVHFVPSQHWSRRGLNDVNEMLWGGFVIEGSSARVFHSGDTAYFEGFKEIGLRYPGIDAAMLPIGAYDPAWFMRRQHMNPEEAVQAFEDLGAARFLAMHWGTFKLTDEPLDEPPRRLDAEWTRRGLARERVEVLPVGGTLTVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE21</accession>
    <name>Q1DE21_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550962.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0840"/>
    <dbReference type="EnsemblBacteria" id="ABF89286">
        <property type="protein sequence ID" value="ABF89286"/>
        <property type="gene ID" value="MXAN_0840"/>
    </dbReference>
    <dbReference type="GeneID" id="41358301"/>
    <dbReference type="KEGG" id="mxa:MXAN_0840"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033631_2_0_7"/>
    <dbReference type="OMA" id="HEVPDYH"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="47792" checksum="19A3FBBFB5E99055" modified="2006-07-11" version="1">MDLKEQLLYGLPVFLAPILIELVVGLLRRKPAYRLNDLLTNVTMSLLTVLGSVVIAGATFVFYGYVYKHHALFSLAKDSAWTWVVAFFAYDFFYYWAHRMHHTMAWMWGVHVAHHSGEDMNFGLAVRQSALGELTTWPFFVPMALLGIAPEVFLGITGIQLIFQYAIHNTYVPPLGWLEYVLVTPSQHRVHHSRNTPYIDKNYGNILVVWDLLFRTYQPELKDQPPVYGLRSSLRSWNPFTAHFHYFVELFQKSAACARLADKVLCFIKGPDWNPPSLRQERFTGPPDGGPSATFQKYDPRLPLPVTAYCVTQFFSLAASILLLAWYLDTLSPGARAVTLGLVLFGTWSLGALMDSRAFAWRQEFARLAGIALLGPALALMEGVPLVSALPILLHPALSAAWLLRFRAAFHEGADTSTRGSSALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DED1</accession>
    <name>Q1DED1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550852.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0724"/>
    <dbReference type="EnsemblBacteria" id="ABF90284">
        <property type="protein sequence ID" value="ABF90284"/>
        <property type="gene ID" value="MXAN_0724"/>
    </dbReference>
    <dbReference type="GeneID" id="41358196"/>
    <dbReference type="KEGG" id="mxa:MXAN_0724"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796522_0_0_7"/>
    <dbReference type="OMA" id="VGQQVGH"/>
    <dbReference type="OrthoDB" id="2118852at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="36331" checksum="A53521529857F637" modified="2006-07-11" version="1">MSRSDVTTSVPVFTQTFRSPCGCVPAHGGACECPARAGARRVSMGCPPSFMVPPAREAPLPSSAASLVGQQVGHFRLLRELGRGSLGVVLLAEHALIQKRVAIQVLHTHVTQDPAQVARFLQAARTLTLIQHAHIVSLYDLGMRDGRPYLVREYLEGQSLTAFAKGPLASALVVDLLTQVCDALGAAHAHGIAHGSLNPASIFLIPDANGRQHVKLLDFGIAGLLPSPDGAADLSVAADLFAVGVLGALLVSGRLSSRGHAAEEPPHGHAREVPPLPAGIPSALSRVLLKAMARRPGDRYASAAELRAALQASVALDGGVAHPEALELERLPSWYTLRGPPGAAPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEI5</accession>
    <name>Q1DEI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550801.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90192">
        <property type="protein sequence ID" value="ABF90192"/>
        <property type="gene ID" value="MXAN_0670"/>
    </dbReference>
    <dbReference type="GeneID" id="41358145"/>
    <dbReference type="KEGG" id="mxa:MXAN_0670"/>
    <dbReference type="HOGENOM" id="CLU_1738548_0_0_7"/>
    <dbReference type="OMA" id="ITVDCVS"/>
    <dbReference type="OrthoDB" id="1578241at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="150" mass="16589" checksum="889EDC0015CAD9E6" modified="2006-07-11" version="1">MPREEGARMFEVINDKNRRTVTVRLSGFVRPNEMRDFASRYRHETDSYGGGRHLVLADMRGLRTLEPESASLFGEVVAYGRQMGCVMCAHVSDSTIARLQTARVASAAAADNNITVDCVSLEEAHSQLAKARSRYFLGATPEDAVEHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ5</accession>
    <name>Q1DEJ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550791.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0660"/>
    <dbReference type="EnsemblBacteria" id="ABF91872">
        <property type="protein sequence ID" value="ABF91872"/>
        <property type="gene ID" value="MXAN_0660"/>
    </dbReference>
    <dbReference type="GeneID" id="41358135"/>
    <dbReference type="KEGG" id="mxa:MXAN_0660"/>
    <dbReference type="HOGENOM" id="CLU_1184023_0_0_7"/>
    <dbReference type="OMA" id="LFWRANL"/>
    <dbReference type="OrthoDB" id="1278107at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25360" checksum="23F728FF70D29598" modified="2006-07-11" version="1">MRMSKTKQQTLGLTMGAVLALTACGTEPMEPSQAPVETDAVEGVDAQAADAKPVDIIALEKQLQESSLAPPAQCNDPSCEGGGGGGEPDPDWPYYTLFWRANLLSLKCITTSDIDGNDEAWLEAEVTGDNQSEVIWNDDYMTPNKRVEWSPLNSYPPPLQFTTQTVGAGGKLVALWDKSMHIFDVQEQIGWTTLRGQTGTFTSILEGHGGKYELTYQVESTGCSPRSQPCPTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEK6</accession>
    <name>Q1DEK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88202">
        <property type="protein sequence ID" value="ABF88202"/>
        <property type="gene ID" value="MXAN_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0648"/>
    <dbReference type="HOGENOM" id="CLU_3236408_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="43" mass="4654" checksum="645B49A2551AA883" modified="2006-07-11" version="1">MSAITTAAMAPHWSPRIGLRSFRHRARAPVARAAEPTPSRACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEW2</accession>
    <name>Q1DEW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550674.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0542"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90924">
        <property type="protein sequence ID" value="ABF90924"/>
        <property type="gene ID" value="MXAN_0542"/>
    </dbReference>
    <dbReference type="GeneID" id="41358026"/>
    <dbReference type="KEGG" id="mxa:MXAN_0542"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033520_0_0_7"/>
    <dbReference type="OMA" id="DWRNVEM"/>
    <dbReference type="OrthoDB" id="335428at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188468" evidence="2">
        <location>
            <begin position="37"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="450" mass="49297" checksum="B80077392F5013BD" modified="2006-07-11" version="1">MNRQHSTSSLGGWKRFRTSVTAFSLAVGAFATPALAAGGFVSATASSYDAPTPPSMAVDGNKATRWSASGAGQWIRGDMGSVKPLNGLDIAWFRGNERINLFDIATSTDGTTFTRVFVGISSGKSADFERVTFPTVNARYVRVTFYGSTQTTWGSITDMAALSGATIPDPEPENPDPENPDPENPDPGPGSTQDKFGVTMLYPTKSGGEQWFLADNATSDKRFDPQNTITRNSDGSWKMKNSKVRMSVFTSTGYSASKIPTYDRDVLASRGYMQAANDWRNVEMTGFIKVNSTSDVSDNFAWYARGGKHNDNNSGCEGSSYKGSLHYDGRVRWQKETWHVSYEQAAYKSGTSALRGRWVGFKSVMRNTKVNGKDAVRLEMYLNENADKKTWKKVYDMVDSGSWGGDASHCGGAVNAMPITWGGPIAVFRWDSATDVDFKWMSVREIPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF90</accession>
    <name>Q1DF90_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550546.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0412"/>
    <dbReference type="EnsemblBacteria" id="ABF88177">
        <property type="protein sequence ID" value="ABF88177"/>
        <property type="gene ID" value="MXAN_0412"/>
    </dbReference>
    <dbReference type="GeneID" id="41357906"/>
    <dbReference type="KEGG" id="mxa:MXAN_0412"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_0_2_7"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="265" mass="27879" checksum="50F2F937D20A3FF6" modified="2006-07-11" version="1">MARMHEVDFHIYGEDLQFVEVELDPGEAAVAEAGTLMYMEDGIEMETIFGDGSEKTSGFFGSLLGAGKRLLTGESLFTTVFLNKSGSGKRKVSFAAPYPGKIIPVNLSELGGELIAQKDSFLAAAKGVSLGIAFQKKLGTGLFGGEGFIMQRLQGDGLAFIHAGGTLHERTLGPGEMLRVDTGCIVAFQPTVDYDIQMVSGIKTAFFGGEGLFFATLRGPGKVWLQSLPFSRLAGRILSASRPGGARDEGSVLGGVGLGSLLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC9</accession>
    <name>Q1DFC9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ORF">MXAN_0370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0370"/>
    <dbReference type="EnsemblBacteria" id="ABF91588">
        <property type="protein sequence ID" value="ABF91588"/>
        <property type="gene ID" value="MXAN_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0370"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_7"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="365" mass="39383" checksum="00FB65440BCF1B36" modified="2006-07-11" version="1">MLAWFALQYSLPPGAFPGAKGEGIPVHTYGLLLALGFITAVTVAGRLAQDEWRTLELKDGAWVDVEGPKKREQIMDMTVWILLGGIGGSRLLFVLVNWQDYARDWTQVFSLGGGLVFYGGLIGASVAAFVFARMHGLDFWRLADVCIPTVSLGQCLGRLGCFSAGCCWGDVAPAHAATAVHFPGSGVAQDLLGGVGNTSSLAYSSQLQDTRYVVEATGEIFHHAAPGAVRISDWVAQQGYTLGVYPTQLFESVGQLVLFVGLLYARRYRRFHGHVLAFWLMAYAVLRSTVELFRGDVERGTLHGLLQSLGAGELAAAVPLEAWYNVSTSQFISLCMFTFGAVLLAQKGRRRESEAESLGPTPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFJ5</accession>
    <name>Q1DFJ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrid_ox_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0298"/>
    <dbReference type="EnsemblBacteria" id="ABF92407">
        <property type="protein sequence ID" value="ABF92407"/>
        <property type="gene ID" value="MXAN_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0298"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818418_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrid_ox_like" evidence="1">
        <location>
            <begin position="182"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="339" mass="37671" checksum="D526710836794879" modified="2006-07-11" version="1">MAQAHGLKSLLGLTKETKPASRLVTVSRRSRLFGQIRRICGRVRTTRRSTTCCPCQGSKCVEVLIDWVDPGGCELGTCCSEMSGAPQMFRHFRTARCTTASERQGGRPDSHVCYLAADSCLLWQPTRQGSGPRNSSPAASPWPARPYVLLELHDGERKVSLMEETGERTMGQPQGVVQGDRREFEELLKDYDTALLTTRGADGHFHTRPMAVAKKHKSGTVLWFATWADTQKVQDLESDPHCSLAFHASEDSATYLSVSGVAEVVRDRRAIHDLWEPGWKPWFPQGPDEGDIALLRFTPEHAEYVHPAGGKLKVLFSTAKALVTKQRPDIAPKKELDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFP2</accession>
    <name>Q1DFP2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0250"/>
    <dbReference type="EnsemblBacteria" id="ABF90078">
        <property type="protein sequence ID" value="ABF90078"/>
        <property type="gene ID" value="MXAN_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0250"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="GMVFQYS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="272" mass="29906" checksum="B82C8EFA9E6810B1" modified="2006-07-11" version="1">MRSSSQTTSEFAFQPPRPGEQLIYFEHLTKAFGAKRVYDDMDLDVRAGETLVVMGGSGTGKSVLLKCLIGLLSPDTGRILFQGHDLARFTEEQFMPVRRHVAMVFQGAALFDSLNVGENVAYPLREHFPDMPADEVRARVAEKLALVDLPNTERLMPSGLSGGMRKRVGLARAIATEPEVILWDEPTTGLDPVTTQSINVLINSMKTRLGCTSIVVTHDMVSAFTVGDRIAMLANRRIVQVGTPREMLHSTVPEVRAFLDARRVELFPGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY9</accession>
    <name>Q1DFY9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550298.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0151"/>
    <dbReference type="EnsemblBacteria" id="ABF91861">
        <property type="protein sequence ID" value="ABF91861"/>
        <property type="gene ID" value="MXAN_0151"/>
    </dbReference>
    <dbReference type="GeneID" id="41357654"/>
    <dbReference type="KEGG" id="mxa:MXAN_0151"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939801_0_0_7"/>
    <dbReference type="OMA" id="LPRAEWF"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="31977" checksum="379062BA52F24BC5" modified="2006-07-11" version="1">MNAEAVQPEWRRDEVSAYYEAKTERLLQRYGPGPRVHYHSGLVDVVPPPGASSEVLRDTVHSAQEALLMELARAVGRFPDGGEVVDVGCGLGGGALYWATEHQAHVTAVTNVPSHVALVRGFAEAAGVSARVRPILCDALSVPGRAAFDAVVAVESACYLPRAEWFRRTRTLLKPGGVLAIADCFLCRPELAPGFDRYWRTRIGSLDEYLSAAHAAGLELEVRDDVSSRVVGFWSLTLELMVHERASAHPTQHPLRALAQAGRGESSREHLRLQQALMDGGLEYGLLVLRRVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVG4</accession>
    <name>MNME_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">MXAN_7506</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557408.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CVG4"/>
    <dbReference type="SMR" id="Q1CVG4"/>
    <dbReference type="STRING" id="246197.MXAN_7506"/>
    <dbReference type="EnsemblBacteria" id="ABF89543">
        <property type="protein sequence ID" value="ABF89543"/>
        <property type="gene ID" value="MXAN_7506"/>
    </dbReference>
    <dbReference type="GeneID" id="41364639"/>
    <dbReference type="KEGG" id="mxa:MXAN_7506"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_7"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000345846" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="218"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="228"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="247"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="442" mass="46134" checksum="46188F603523ADBC" modified="2006-07-11" version="1">MTSSSMTIAALATAPAAGAVGILRLSGPEALDVGRLLAPGVPAQPTPRHAYLASFVDAEGRSLDEGLFLYFRGPQSFTGEDVVELQAHGSPRLLRLLLTRALEDARVRHAAPGEFTRRAFLNGRLDLTRAEAVADLVAADSEAAVRAAAAGLSGALASRVQALEEPLRALHADMEGVLSFPDEAEGADEDVGERVTALRAQAETLLAEVGRGRLVRRGARVALFGPVNAGKSTLFNRLVGEARALVDDEPGTTRDALEARVEWDGLAVTLFDTAGLRETPGRVEALGIARTRALLTGVDLAVLVLPPGVTQAEVEAWTRDVGGTPVLVVDGKCDVAEVSSSPRQRVSGLTGEGVDALRDDMLGRLWGGGTPSAVALVSERHADALRRASEALGRAESASRVSTLEVVSGEVGLALEALGEVSGTVVSEALLDAIFQRFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL9</accession>
    <name>Q1CVL9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7449"/>
    <dbReference type="EnsemblBacteria" id="ABF92048">
        <property type="protein sequence ID" value="ABF92048"/>
        <property type="gene ID" value="MXAN_7449"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7449"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_2_7"/>
    <dbReference type="OMA" id="YGNNTVG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="18746" checksum="136C9759AD7622C9" modified="2006-07-11" version="1">MIGSLVTDALELAKAANGNSDAKSIAKVVLTSDSYRITALNRAREAALAYRIPLVNHVLRVAQTAVMGIEIGKDVTLGKGVYFVHSLGVVIGGDARIGDRVRFYGNNTVGTAKDNGYPVIEDDVWIGAGARILGPVRIGARSRIGANAVVLQDVPPDSVAVGIPARIFPRKDTDEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVV8</accession>
    <name>Q1CVV8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557270.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7357"/>
    <dbReference type="EnsemblBacteria" id="ABF86385">
        <property type="protein sequence ID" value="ABF86385"/>
        <property type="gene ID" value="MXAN_7357"/>
    </dbReference>
    <dbReference type="GeneID" id="41364518"/>
    <dbReference type="KEGG" id="mxa:MXAN_7357"/>
    <dbReference type="eggNOG" id="COG3825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059555_0_0_7"/>
    <dbReference type="OMA" id="VWDKREF"/>
    <dbReference type="OrthoDB" id="1121563at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="402" mass="44634" checksum="0C8B645DC0BB6905" modified="2006-07-11" version="1">MFLPFFYELRRRGLKVGAQEALALAGALRAGLHDSHLDGFYHVARALLVHSETQLDAFDQAFLAHFQGVETASLELTQELLNWLEEARERPDLSPEEVALLEQLDPEEIRRLFEERLKEQKERHDGGNRWVGTGGTSPFGNNGFGREGIRVGGGAGNRQGRALMQAGARKYAGYRDDVVLDTRQMAVALRKLRAFARDGAPDELDVDESIAATARNAGELEVVTRPPRRPNTRVVLAMDVGGSMDPYAALVSRLFSVASQATHFKELRTYYFHNCVYGKLYATPQLTGGITVPELVAQVGRHHKLVMVGDASMAPYELSIRTDAQGHYKTDGLEGLTWLMQLAQHFERNVWLNPEPMGTWRSGTISVIARIFPMFALTVEGLGEAVTHLTRGRTVRGAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW0</accession>
    <name>Q1CVW0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vegetative protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557268.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88193">
        <property type="protein sequence ID" value="ABF88193"/>
        <property type="gene ID" value="MXAN_7355"/>
    </dbReference>
    <dbReference type="GeneID" id="41364516"/>
    <dbReference type="KEGG" id="mxa:MXAN_7355"/>
    <dbReference type="HOGENOM" id="CLU_092039_0_0_7"/>
    <dbReference type="OMA" id="PKAWVRK"/>
    <dbReference type="OrthoDB" id="1838394at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="27647" checksum="F9AE829E5730CBEE" modified="2006-07-11" version="1">MSIANALGEVFRRELDAQLVPLQQAVRRMEEGLEALELLREVTHRLAPLTSRLGAMAGVRTPTELPASTRGGRKQVVAAPKGRAAVGRPVAAKPVVSQARTEEGTRACAVIGCERPSRSKGYCSAHYQKLRLLMRTNRRPSAWKDDALPQSVGDVTLPRGRAASKALREGGARKKAPAPVVAPPPAEEKAPAAAKKSAGRKAAGAKKAARAKKAPAAAKKSVAKKAPAAKKAAAKGGRQVKTTKAKVGAGKRKKGRSSSQGSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVX3</accession>
    <name>Q1CVX3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557256.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7337"/>
    <dbReference type="EnsemblBacteria" id="ABF87855">
        <property type="protein sequence ID" value="ABF87855"/>
        <property type="gene ID" value="MXAN_7337"/>
    </dbReference>
    <dbReference type="GeneID" id="41364498"/>
    <dbReference type="KEGG" id="mxa:MXAN_7337"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862528_0_0_7"/>
    <dbReference type="OMA" id="ICDVERM"/>
    <dbReference type="OrthoDB" id="1313353at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="330" mass="36760" checksum="E5276D8985884637" modified="2006-07-11" version="1">MMRRSAPPGESEVQEAEGARRRRLNRGTRSLLIVCTVVTLIHLIPLFISRNMPEQRLSIARAMSSVSQRVPFLRPMKDDAKATPAELREAATLLLNGAPDDAHALVLEAERRNPLEVETQLLLARICDVERMSRCVSTALSRAETLAPRDARPDLLRAELQEKDGDVVGAAEAMERAHEKAPGDPLVGLRYVHLLSAAKRGEEALAVLQKLEGRLPHARFLVEQGRVHSREGHDAEAVKLFRAAVAEDPKLSMGFFELGLAWHRLGQVDTAEEALRQADRLDRADPKALAALCAIQVEERRIDDARLTRMDLERRFSGQPELIRKSCSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW11</accession>
    <name>Q1CW11_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557218.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7299"/>
    <dbReference type="EnsemblBacteria" id="ABF92925">
        <property type="protein sequence ID" value="ABF92925"/>
        <property type="gene ID" value="MXAN_7299"/>
    </dbReference>
    <dbReference type="GeneID" id="41364462"/>
    <dbReference type="KEGG" id="mxa:MXAN_7299"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052920_2_0_7"/>
    <dbReference type="OMA" id="IVARSWQ"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="350" mass="39500" checksum="5529932569E55C3D" modified="2006-07-11" version="1">MYAQVVDEADIQYAHRVDRKALAAITREMSKVNNGRALWAMAAQWLVIAAAFAFVLFVDRWWAWPVAAVLIATRQHALLALMHEAAHYHLLSNRKVSDVVSDLLCAFPLNMTTAGYRHEHMLHHRYVNTPKDPYLAGQLVDASWHFPRTPMRATAVFLADALGLYAPNHLKVVLPWTYWGRLVGRAQPRISAGEHLRYWLYVATLVTVLVTTGAWLHWLLLWVLPTTTVMMAFFRMRALGEHPIEETKSGDETRETRDILGTALENFFIAPLNVNLHLTHHAFPSVPFYNLPAMHAQLDKAGLLEDGVNQFDTYLGKENSLIQYLTREPEASAAAAAAAQPSRLSQPLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW75</accession>
    <name>Q1CW75_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92892">
        <property type="protein sequence ID" value="ABF92892"/>
        <property type="gene ID" value="MXAN_7235"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7235"/>
    <dbReference type="HOGENOM" id="CLU_3009560_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="56" mass="6399" checksum="66641B300D215F44" modified="2006-07-11" version="1">MPPWDSQMGRRLSTHANTLLDQKLAIVSVTRSPVSTWTMSHWSASFRLRVSKPSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWM1</accession>
    <name>Q1CWM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557008.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7089"/>
    <dbReference type="EnsemblBacteria" id="ABF87079">
        <property type="protein sequence ID" value="ABF87079"/>
        <property type="gene ID" value="MXAN_7089"/>
    </dbReference>
    <dbReference type="GeneID" id="41364264"/>
    <dbReference type="KEGG" id="mxa:MXAN_7089"/>
    <dbReference type="HOGENOM" id="CLU_1330752_0_0_7"/>
    <dbReference type="OMA" id="PLRMMTL"/>
    <dbReference type="OrthoDB" id="1236170at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187717" evidence="1">
        <location>
            <begin position="22"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="22029" checksum="22C400F3C3943B32" modified="2006-07-11" version="1">MTWTIRSLLLGVFLLSGCKHTGGGSVTPTPTQPQACDAQQAQISREADERASPWSVEQHLAKNFPGKKVSWLMTDAAYQNFVVKPNAQNFGRCNDSVCYLFAAPSETIQAAVEKSMVNGAHDPAVIGQALGLPAKNFEGPLRMMTLDLAATGVCVRLPVDSDPGVWKCTSEEDTDCFKFGGYTSGGVPELMVIDAPVSHAVVTEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWN3</accession>
    <name>Q1CWN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-like beta propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556996.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7077"/>
    <dbReference type="EnsemblBacteria" id="ABF92170">
        <property type="protein sequence ID" value="ABF92170"/>
        <property type="gene ID" value="MXAN_7077"/>
    </dbReference>
    <dbReference type="GeneID" id="41364252"/>
    <dbReference type="KEGG" id="mxa:MXAN_7077"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059007_0_0_7"/>
    <dbReference type="OMA" id="YEFNAFI"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="36315" checksum="3F24F1E7953F48A3" modified="2006-07-11" version="1">MAGMSSMRGVLLMMTLWELGCGAHGGRPATALENHGGTCTPELYGAGLFTTGAWDFFMAFSPDQRRVLFGRADDRFQQYTLYETQLTEEGHWSRPVLPRFATEWSNADPHFSPDGRTVYFISNRPELGEQGPRSSYDIWAASLDADGAWEDARRLPAPVNDKHRDEWSPAVAANGNLYFGGERDGTLGGSDLWVSRWVDGAYQPPENLGPGINSSVHELEPWIAPDESYLIFSALRREDGLGGYDLFLSRKVDGAWTPARRLCEGINTPASDYNHSVSPDGKWLYFSSTRPFTGDVGARFDAPRDDSAVQGIGRGTGDMYRIPMSALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWP4</accession>
    <name>Q1CWP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556985.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7066"/>
    <dbReference type="EnsemblBacteria" id="ABF89223">
        <property type="protein sequence ID" value="ABF89223"/>
        <property type="gene ID" value="MXAN_7066"/>
    </dbReference>
    <dbReference type="GeneID" id="41364241"/>
    <dbReference type="KEGG" id="mxa:MXAN_7066"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_7"/>
    <dbReference type="OMA" id="GEQRFNE"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="13179" checksum="E02C6E4909467A8B" modified="2006-07-11" version="1">MEHPLTRCARFEKASELMGKRWTGLILRILLAGPRRFGELTDAIGSISERVLSERLKELEAEGVVSRHVDAGPPIRVAYQLTEKGQALWKVVDELARWAERWVDMKPSAARKRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWX7</accession>
    <name>Q1CWX7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556902.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6982"/>
    <dbReference type="EnsemblBacteria" id="ABF92872">
        <property type="protein sequence ID" value="ABF92872"/>
        <property type="gene ID" value="MXAN_6982"/>
    </dbReference>
    <dbReference type="GeneID" id="41364159"/>
    <dbReference type="KEGG" id="mxa:MXAN_6982"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_5_7"/>
    <dbReference type="OMA" id="GVMFFED"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="31221" checksum="99A2005EDF0F3598" modified="2006-07-11" version="1">MASGHQPPEGQAALWNGPAGQAWVDSRDLLEGMFKPFEDLLVEAVQARGARQVLDVGCGTGSTTLAVARRLGAQGHCVGIDISAPMLAAARARAEAEHVAASFIEANAEHHAFERGRFDMVISRFGVMFFDDAVQAFVNLRRSARENAGLSFVVWRSPSENPFMTTAERAAAPLLPNMPARQPNAPGQFAFADGDRVHRILEQSGWMDIGIHPIDATCTLPEQGLLQYVTRLGPVGRVLHEADERTRTRVIETVRAAFNPYVHGDEVRFTAACWRVEARAPAEALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWY0</accession>
    <name>Q1CWY0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556899.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6979"/>
    <dbReference type="EnsemblBacteria" id="ABF87783">
        <property type="protein sequence ID" value="ABF87783"/>
        <property type="gene ID" value="MXAN_6979"/>
    </dbReference>
    <dbReference type="GeneID" id="41364156"/>
    <dbReference type="KEGG" id="mxa:MXAN_6979"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046130_1_1_7"/>
    <dbReference type="OMA" id="LNRWHLM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="223"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="436" mass="46716" checksum="DE55C867CE20BE78" modified="2006-07-11" version="1">MTPPPQAAPPLPEPDSRARINLEWLLRLRWGLLLGQTLVIGVAAFGLELALPIPELAALLGLEALTNVSVRAWLARGLRVTEGTLGKLMLWDTLVLTGLLALSGGTHNPFTTLYLVNVALGTVLLPSRWMWGLLGFTLTAFGSLFVLQDVELPAGLSRPDHAELMRLHINGMWVAFAVAAGFIVYFVQRVTRALGAREQELAQARALHARREKVASLATLAAGAAHELSTPLSTIAVVTKEVERALATAGTSESVREDLRLIRQQVDRCRDVLVQMSADAGQTTGEPFHPVPLGRLVEDMLAELPGAERVTVELPTEARDWRVHGPPRALARVLRGLVKNALQASQVSRPVELRVQARGEGALLEVRDAGTGMAADVLSRAGEPFFTTKPPGEGMGLGLFLARTLVEQLGGSLELRSTPGRGTTASLSLPVTEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWY5</accession>
    <name>Q1CWY5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556894.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6973"/>
    <dbReference type="EnsemblBacteria" id="ABF91236">
        <property type="protein sequence ID" value="ABF91236"/>
        <property type="gene ID" value="MXAN_6973"/>
    </dbReference>
    <dbReference type="GeneID" id="41364151"/>
    <dbReference type="KEGG" id="mxa:MXAN_6973"/>
    <dbReference type="HOGENOM" id="CLU_105840_0_0_7"/>
    <dbReference type="OMA" id="DIRIHAD"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="24877" checksum="DE76E04E3B705CA0" modified="2006-07-11" version="1">MHPKRWWPASLLLVCLACESAPRKAHETEHYGFISDDSDYVWARGPWSGVEPSRDVDDVIDRLCPAIMKLPGATDRDYGQEYCGLIYSRGDGIYRVSHPSPLGRWQLRREATKKSCFPVRKVIDPEARSLSILADYHSHPWHPSPLSEPDRRAANQLWLIKIQFDSACHIQKLIPHLDDVDRPGEVYSRRGKQWVRIGLIKPADKPFGFITPVGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX48</accession>
    <name>Q1CX48_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_6911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6911"/>
    <dbReference type="EnsemblBacteria" id="ABF90778">
        <property type="protein sequence ID" value="ABF90778"/>
        <property type="gene ID" value="MXAN_6911"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6911"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_2_7"/>
    <dbReference type="OMA" id="KAPDFRQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010917">
        <property type="entry name" value="TonB_rcpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01156">
        <property type="entry name" value="TONB_DEPENDENT_REC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="368"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="664" mass="71439" checksum="8CCDE2B5C85D85EB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX84</accession>
    <name>Q1CX84_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">phaC</name>
        <name evidence="2" type="ORF">MXAN_6874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556797.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6874"/>
    <dbReference type="EnsemblBacteria" id="ABF86643">
        <property type="protein sequence ID" value="ABF86643"/>
        <property type="gene ID" value="MXAN_6874"/>
    </dbReference>
    <dbReference type="GeneID" id="41364061"/>
    <dbReference type="KEGG" id="mxa:MXAN_6874"/>
    <dbReference type="eggNOG" id="COG3243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035017_0_0_7"/>
    <dbReference type="OMA" id="YLIDWGY"/>
    <dbReference type="OrthoDB" id="891360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="42187" checksum="872C3AB6D8C6010C" modified="2006-07-11" version="1">MTASTPQRLRSFVTGQVELTRAVAHALKSRPFNPYPYLKPFIERASGVREPPISATPHTVVYTRGSMRLLRYAAPRRRHRTPILFVYSLINRWYILDFLPGRSLIEHLTREGYDVYAIDWGVPGQDEERLTWDDLLGGLIQTAVRWTLRVSKSRDLTLYGYCMGGTMALAYTSLYPEGVRNLVAQATPVDFSKGGLYTLWTSANHFDVDSLVDAYGNVPTPVLESGFLMAAPVQRLTRWLEVCRRIDDPEFVTTFLAMERWGADPVPFPGEVYRQYIKDCYQQNLFPQGLMEVGGERVDLRRIQCAILNVIAEHDTIALPAMSEPLPSLVSSKDCETRRYPVGHIGLSASSKGATKVWPSISAWIGARSKPMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX96</accession>
    <name>Q1CX96_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adventurous gliding motility protein AglS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aglS</name>
        <name evidence="8" type="ORF">MXAN_6860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556785.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6860"/>
    <dbReference type="EnsemblBacteria" id="ABF86057">
        <property type="protein sequence ID" value="ABF86057"/>
        <property type="gene ID" value="MXAN_6860"/>
    </dbReference>
    <dbReference type="GeneID" id="41364049"/>
    <dbReference type="KEGG" id="mxa:MXAN_6860"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120814_0_0_7"/>
    <dbReference type="OMA" id="FSCATAG"/>
    <dbReference type="OrthoDB" id="1307192at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21330" checksum="40655B70383C80A9" modified="2006-07-11" version="1">MAIQVPGKRYGKRLQHSKVFGHGGTAKKSGYSDLLITPLVDMFIIIVLFLIANFSATGEVLMMTKDIELPEAVNVKEVEMHPVVMVSGEQISVSGTIIGRVEDFTKDEYLNIPSLEEKLRDMKKQYEDLHSMAQDTANTFKGDINIQAHKDVEYSIIKRVMFSCATAGYNNINFAVITAGDAEAVKAASAKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI4</accession>
    <name>Q1CXI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6772"/>
    <dbReference type="EnsemblBacteria" id="ABF89937">
        <property type="protein sequence ID" value="ABF89937"/>
        <property type="gene ID" value="MXAN_6772"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6772"/>
    <dbReference type="eggNOG" id="ENOG50319Q3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048280_0_0_7"/>
    <dbReference type="OMA" id="QEDRAQS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="483" mass="51260" checksum="E5D2D0382219462B" modified="2006-07-11" version="1">MEGGEDVQAEDEAGCPRATPGQVEAGRGARVRQAPQVLRLLTVLLAVGTGVGCPMGPCEEHGPSPLFNDAMVGVGQPQALTVHGVFSRCDSSQEDRAQSVSVEVRDPQNRVVPATAQLAVHGRSAIVRFTPEQTGRHHLVVAFSPVGSIRQSSLYAVEDHSAQAPLADLSTVLECRGVDRTSSGTWLCGSQALRTPDQEPQPLGDYFAPAVVAGDVVWVTEAARVRRYVDLGNGPLATSADAPFPATGAPADAPPHARLATATELLLLDETHLHRYAFSEEEGLRATGSPPVPPSRLATFSDDIPSLLMRAGERLLVVRIADAPAPATMAIEACPYQLDAAGAPQPVPGEPCHSVPGLPVGHEEGVLWVRAASGPQSLALLRYSAASGRLRLDGVMEMTSSFHFQGAERLRTTGFGVPVVSPATGSSRPYAVPRWSAETGTVVLELLPSPDGRRPPFVGRRYFHLEHWNILYGVKVYARPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXK7</accession>
    <name>Q1CXK7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial Ig-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6749"/>
    <dbReference type="EnsemblBacteria" id="ABF87251">
        <property type="protein sequence ID" value="ABF87251"/>
        <property type="gene ID" value="MXAN_6749"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6749"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549594_0_0_7"/>
    <dbReference type="OMA" id="ENRIEHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187883" evidence="1">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="496" mass="51083" checksum="CC152EDF721EC6EA" modified="2006-07-11" version="1">MRASRMRCLLLSLFVAGCGADSGKGDGPPPPRPTPTDSTITVAGSKNTLAVNEVLVLTASGRDSSGQPVVLDDVIWSSSEASVVRVERDGTVTGMGAGTATVTAASGNKSGNLTLTVRGAIHRNGSILTSETWREVDNPHIVLDDIVVAGPGTPVLTIEAGSIIRLEHGASIEIGYGGEGGTLRVQGTAEKPVTFTTNAASPAPGQWQGLYLLEGTTSSNISHAVVEYCGSNSGYGAANDACIIVSGSTVRPNFQDVTIQHSASQGITFMYEGAFGSNSRGLTVTDVATSPISMGVNQLGSLPGDSVFKTNGRNVIRSPGGQVDRSQTWVNVGVPYVMEDSVYVDGATTPTLTLSPGVTLRFGRLSYFEIGTGEGGNLRAEGTAEAPITLTADAEFPMSGHWQGLAFGEMATAASKLTQAVVEYGGAPASDGNPNANVRVIVDKGPIITQTTLRHSMGCGITRATTPNYDTFTTDFTAPSLGNVFSDNSGSAQCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXS6</accession>
    <name>Q1CXS6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556605.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6680"/>
    <dbReference type="EnsemblBacteria" id="ABF92173">
        <property type="protein sequence ID" value="ABF92173"/>
        <property type="gene ID" value="MXAN_6680"/>
    </dbReference>
    <dbReference type="GeneID" id="41363873"/>
    <dbReference type="KEGG" id="mxa:MXAN_6680"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359190_0_0_7"/>
    <dbReference type="OMA" id="RFTEAWY"/>
    <dbReference type="OrthoDB" id="1839456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="23089" checksum="905A7650A4B3A92A" modified="2006-07-11" version="1">MPNTRALYRSVGLKEAELFLVSGCSAFLAPTARPAHLLPGDERRVRTANCRDWNTPDAGSGHAGFVTAFDVGADYASRFPVRTVGNSRHQELWVPAEELATFNQHIQGPVRFTEAWYGPGYLGPDTTLGPLERQLLALFEQRSDALPLIQANTAACLFNSAWWSTAPAAAQGLNPSDHLRLLDRLHQTWVTLHPTWPLPAPGGNRQTDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY07</accession>
    <name>Q1CY07_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6596"/>
    <dbReference type="EnsemblBacteria" id="ABF92420">
        <property type="protein sequence ID" value="ABF92420"/>
        <property type="gene ID" value="MXAN_6596"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6596"/>
    <dbReference type="HOGENOM" id="CLU_3404487_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="30" mass="3376" checksum="273C9CA7594ACF38" modified="2006-07-11" version="1">MPAPVKLQGWRRREGSRSREAVVTPLVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY28</accession>
    <name>Q1CY28_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556503.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6573"/>
    <dbReference type="EnsemblBacteria" id="ABF92445">
        <property type="protein sequence ID" value="ABF92445"/>
        <property type="gene ID" value="MXAN_6573"/>
    </dbReference>
    <dbReference type="GeneID" id="41363778"/>
    <dbReference type="KEGG" id="mxa:MXAN_6573"/>
    <dbReference type="eggNOG" id="ENOG5033CDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100187_0_0_7"/>
    <dbReference type="OMA" id="FPGCAGV"/>
    <dbReference type="OrthoDB" id="1551331at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="254" mass="25562" checksum="4E92C22607A5A071" modified="2006-07-11" version="1">MSHRGLHRFAWGTALAVLLGTAACGDDSSGVGEDAGTDPVRDDAGQPDGSTSLEPDAGLPPEDPYADEVVLFLPGDFAGFGQDRFPDVVLGPPSGLGPDNGSLDVLSLGRGGIIELRFTDIAVVDGPGVDLLVFENTFRVAGGAATYSERGIVSVSDDGVTWYPFPCATTDAAGGYPGCAGVATVQANPANGVSATDPAVAGGDGFDLATVGLKRAQYVRIVDAGNNRYGGTSGGFDLDAVAVVNGVSLRSGTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY37</accession>
    <name>Y6564_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein MXAN_6564</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_6564</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556494.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CY37"/>
    <dbReference type="SMR" id="Q1CY37"/>
    <dbReference type="STRING" id="246197.MXAN_6564"/>
    <dbReference type="EnsemblBacteria" id="ABF87526">
        <property type="protein sequence ID" value="ABF87526"/>
        <property type="gene ID" value="MXAN_6564"/>
    </dbReference>
    <dbReference type="GeneID" id="41363769"/>
    <dbReference type="KEGG" id="mxa:MXAN_6564"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_7"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258974" description="Nucleotide-binding protein MXAN_6564">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <sequence length="287" mass="31975" checksum="74B06128586FB37C" modified="2006-07-11" version="1">MTAPAKQIVIITGMSGSGKSTAIRALEDSGFFCIDNLPVLLLPKLTELAGGGHFERMALVVDVREGVFLKDAPRILAEVRRAGHQVEVLFLDASDDSLIRRFSETRRRHPLAPNGTVAEGIKAERQALRDLRELADQVIDSSTLNVHDLKRMVQARFSPEPAAGPSLSIMSFGYRYGVPPQADLVLDVRFLPNPYFVPEMKGLTGKVPKVAAYVLEREETQQFLEKVVDLCRFLFPRYQKEGKAYLTVALGCTGGKHRSVAIAAELTQRLTDEDTRVQLWDRDIEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY89</accession>
    <name>Q1CY89_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556442.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6511"/>
    <dbReference type="EnsemblBacteria" id="ABF91446">
        <property type="protein sequence ID" value="ABF91446"/>
        <property type="gene ID" value="MXAN_6511"/>
    </dbReference>
    <dbReference type="GeneID" id="41363719"/>
    <dbReference type="KEGG" id="mxa:MXAN_6511"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585037_0_0_7"/>
    <dbReference type="OMA" id="DSPGECL"/>
    <dbReference type="OrthoDB" id="765897at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="467" mass="49725" checksum="761F7E4FE79C680A" modified="2006-07-11" version="1">MLPRVRSTRQGDDMTLRGAGALLLSVLLVGCATPRVVRLDTGQGEPIVYLPPKSAKPVEVDEDAFRRVMTRLVLDMRFSLHDGAAERPRVRLASWDSGPQSAGSDYGDWCSRQDSPGECLTLLEGGFSFLDAKARRQMALAFAWDGVWDGVQDAVKEVVNPLALKAMLTSAMAAYMFLIVAPEPVTKVVAVALTTFVLAYLGVDAFMGLVEGWQRLSADADRAESFRELEYAGHRFGRVMGENGARVLILALTAALSGGAASMASKGPTLPGFASAALAAEAQAGFRLSAAMAGGVRSITVAEGVMTVGLAPHAVAMTARGPGSEKSPRTDSTSSEQILTNQLPDLLPEELEIASSLGVQPVSVDSAQFARYARGERVKWVLTQEGQLRIVPHRWSEVEISHAVASGGKPVVAAGEAELAVHGTTYFGIRITPQSGHYLKGASEAMSRRVVELGRKAFAQYGITFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM0</accession>
    <name>Q1CYM0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6379"/>
    <dbReference type="EnsemblBacteria" id="ABF87800">
        <property type="protein sequence ID" value="ABF87800"/>
        <property type="gene ID" value="MXAN_6379"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6379"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917736_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="33665" checksum="C71AA977C5A9E4AE" modified="2006-07-11" version="1">MDRLGLRDVTLVMQDWGGPIGIGLAERPPSRTSRRSSSGRSRTWAFPSATGSGGSRPSRITGASSSPAWATSSSRTPRTTSSRRFARSCPPPAPGFAWEGLRADGRGPRRYGPCVQRERSPRPFTTQRPPADAPPPLEPAPAGMASRLHLHGRTGLASPRPTGMDGMPPFIIRTQQGLTLQHASEARFRREMVEHLRTHFPERTTGLEARELDAHVERALQAARDYGLASRRELCRFLNLCGLHGWDFDRRPRNAWMKAMLTAPDVTAPGARLDRLVEHSLHRLELESHRTRLEGEFGLHEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYW2</accession>
    <name>Q1CYW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556222.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6284"/>
    <dbReference type="EnsemblBacteria" id="ABF91959">
        <property type="protein sequence ID" value="ABF91959"/>
        <property type="gene ID" value="MXAN_6284"/>
    </dbReference>
    <dbReference type="GeneID" id="41363504"/>
    <dbReference type="KEGG" id="mxa:MXAN_6284"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033631_3_1_7"/>
    <dbReference type="OMA" id="PEFHHWH"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="225"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="395" mass="44874" checksum="22D03EE705614E75" modified="2006-07-11" version="1">MLASDGKWNRLAPRQSLSGRLLLDLPLTPALRINLGKRAGVTGGLLGVLCVCVEFCFLFPHLLVSNDGRAFYVEHLGVFRGILQAAIVATFALGALSVLTLRSKAHGGIAMLLALVAMLLGGSQAEPLTHQPRALSAGLDYFALELLVLGLLFIPMERLWGLHPQRIFREGWQTDLKHFFVSHVGVQLISFSVMIPVQVFFSWAVRMDFQAHVAAQPVWLQFFEILLVVDLVSYWVHRAFHQVPWMWKFHAIHHSSQQMDWLASSRSHLVDVLVNRFAGFIPVFLLGFSPAAIYGYLVFVSFHAVYIHANVSHRWPYLRWVFATPEFHHWHHTSDEEGIDKNFAVFLSFIDVIFGTAHLPEHWPSRYGTTKFQPPETYLGQLAYPFQRHEETPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC6</accession>
    <name>Q1CZC6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556061.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6112"/>
    <dbReference type="EnsemblBacteria" id="ABF87011">
        <property type="protein sequence ID" value="ABF87011"/>
        <property type="gene ID" value="MXAN_6112"/>
    </dbReference>
    <dbReference type="GeneID" id="41363347"/>
    <dbReference type="KEGG" id="mxa:MXAN_6112"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_4_7"/>
    <dbReference type="OMA" id="HHFKVIY"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23324" checksum="5327AF5ED8062554" modified="2006-07-11" version="1">MSASSSRGILFDLDGTLVDSLPDIIDSFLHAFGHLGLPAPTYEQVRALIGHPLDWMYSQFAPDHVPALCVAYREHYPLNFHRRSRPYPGVVEVLRALRERGYLLAVATTKRPDMARKFVDAMGLGPLLHHVQGTDGFPHKPAPDVIHHALAALGTGGLWMVGDTALDLRAGQAAGLRTYAVTWGTHPVDVLAGASPDELQPDLQRLLTHLPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZG9</accession>
    <name>Q1CZG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556018.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6069"/>
    <dbReference type="EnsemblBacteria" id="ABF86948">
        <property type="protein sequence ID" value="ABF86948"/>
        <property type="gene ID" value="MXAN_6069"/>
    </dbReference>
    <dbReference type="GeneID" id="41363305"/>
    <dbReference type="KEGG" id="mxa:MXAN_6069"/>
    <dbReference type="HOGENOM" id="CLU_111102_0_0_7"/>
    <dbReference type="OMA" id="SPNARAM"/>
    <dbReference type="OrthoDB" id="1439206at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19445" checksum="8A3289F14C696138" modified="2006-07-11" version="1">MVMKIPSQSRWVPGLLVALGTSACDSSEDDLMRALGDPVLDAFEIRLQGQDAAQYEKVLLGMGQVEVTSFGEPVRFEPSPNARAMDLSDADHAHLLGRFFLPRNVKQVDITVRLDDVGAFKEDSLAGLINAQAGTIQFSTTRSALEQRSRVVIHLHLKDSLFDGRGGKTLLPATYIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D087</accession>
    <name>Q1D087_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5799</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555750.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5799"/>
    <dbReference type="EnsemblBacteria" id="ABF92010">
        <property type="protein sequence ID" value="ABF92010"/>
        <property type="gene ID" value="MXAN_5799"/>
    </dbReference>
    <dbReference type="GeneID" id="41363042"/>
    <dbReference type="KEGG" id="mxa:MXAN_5799"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002521_0_0_7"/>
    <dbReference type="OMA" id="NTAGREY"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188213" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6531" evidence="8">
        <location>
            <begin position="714"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1740"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1755"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1798" mass="194003" checksum="26C4E10D51C3A0E2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D099</accession>
    <name>Q1D099_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT</name>
        <name evidence="3" type="ORF">MXAN_5787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555738.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5787"/>
    <dbReference type="EnsemblBacteria" id="ABF85864">
        <property type="protein sequence ID" value="ABF85864"/>
        <property type="gene ID" value="MXAN_5787"/>
    </dbReference>
    <dbReference type="GeneID" id="41363030"/>
    <dbReference type="KEGG" id="mxa:MXAN_5787"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="IREDKVH"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="372" mass="40625" checksum="589ACE4E5B596470" modified="2006-07-11" version="1">MANLHQLLKAMVEKGASDLHVTTGSPPQLRVDGELVPLKTAPLTPVETKQLCYSILTDAQKHKFEEDNELDLSFGVKGLSRFRANIFMQRGAVAAAFRTIPFKILTFQELGLPPVVAELVKKPRGLILVTGPTGSGKSTTLASMIDKINTERHEHIMTIEDPIEYLHPHKNCLVNQREVGADTRNFKTALKYILRQDPDVVLVGELRDLETIEAALTIAETGHICYATLHTNSAVQTINRVLDVFPPYQQPQVRAQMSFVLEGVMSQALVAKAGGPGRILALEVMVPNPAIRNLIREDKVHQIYSSMQVGQAKFGMQTFNQALAALLLRRLITQDEAFGRSSDAEELRNILATGGGGALPGMQRPGGGAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D157</accession>
    <name>Q1D157_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5474"/>
    <dbReference type="EnsemblBacteria" id="ABF88677">
        <property type="protein sequence ID" value="ABF88677"/>
        <property type="gene ID" value="MXAN_5474"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5474"/>
    <dbReference type="HOGENOM" id="CLU_1309041_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="23895" checksum="20EEC1285EA58340" modified="2006-07-11" version="1">MGSTFCPPRGVVRVRVGANTVRRVFVVALRAPRRVARLFLHVAALSLLRLVWRLGQRPRRFHIWHGDVLLLENIGSRQSCDGRAHMTLHRFLGTARGLLRNAVGIPLTLYMALRPGKKEAERAQRNAETLIAACRAYQARHGQLPDTLEQLVPEFLPQLPPAKFSGPHFGFTYDVSGPADARRHVLGWTDRIPFGRPFFVFEEERWGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D171</accession>
    <name>Q1D171_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87500">
        <property type="protein sequence ID" value="ABF87500"/>
        <property type="gene ID" value="MXAN_5459"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5459"/>
    <dbReference type="HOGENOM" id="CLU_1873206_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="15673" checksum="D73C5AD0C5439240" modified="2006-07-11" version="1">MLRIRESQMSSLRSAAMDSRVAQLVTALLAEPSAAEPGWTRERLEPVVRRVVDRGIFSLDDVRVYVQLAESLGDDFESQRRHAWMRSWLDDASVSDPVARLHRVVRERRRREDVAAQNQRKEAAFRLRHAPPGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D174</accession>
    <name>Q1D174_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555414.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5456"/>
    <dbReference type="EnsemblBacteria" id="ABF87497">
        <property type="protein sequence ID" value="ABF87497"/>
        <property type="gene ID" value="MXAN_5456"/>
    </dbReference>
    <dbReference type="GeneID" id="41362713"/>
    <dbReference type="KEGG" id="mxa:MXAN_5456"/>
    <dbReference type="HOGENOM" id="CLU_241820_0_0_7"/>
    <dbReference type="OrthoDB" id="2107280at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1599"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1670" mass="183891" checksum="F68ABDABFB261CB8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1C0</accession>
    <name>Q1D1C0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555368.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5406"/>
    <dbReference type="EnsemblBacteria" id="ABF86726">
        <property type="protein sequence ID" value="ABF86726"/>
        <property type="gene ID" value="MXAN_5406"/>
    </dbReference>
    <dbReference type="GeneID" id="41362669"/>
    <dbReference type="KEGG" id="mxa:MXAN_5406"/>
    <dbReference type="eggNOG" id="COG5649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131962_0_0_7"/>
    <dbReference type="OMA" id="GVPVWEH"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="137" mass="14807" checksum="CF158DBF51E40392" modified="2006-07-11" version="1">MKSQPKTDGESASKLISDRIAELGDWRGEALARVRALIKEAVPDVVEEWKWRGTPVWSHGGGLCTGEAYKSAVKLTFFKGASLEDPSKLFNSSLEGNVRRAIDIHEGEAFDAKAFKALIRAAAALNTAGGKKPRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F4</accession>
    <name>Q1D1F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555334.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5369"/>
    <dbReference type="EnsemblBacteria" id="ABF87901">
        <property type="protein sequence ID" value="ABF87901"/>
        <property type="gene ID" value="MXAN_5369"/>
    </dbReference>
    <dbReference type="GeneID" id="41362637"/>
    <dbReference type="KEGG" id="mxa:MXAN_5369"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244217_0_0_7"/>
    <dbReference type="OMA" id="LAQEWVM"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="24015" checksum="8543F5390D1FD254" modified="2006-07-11" version="1">MSDLIEQALLRYDGLPVAERFHVHARAFSAPLLAMAARTPVGAVADIGCGHGLLSALLALEDPRRTVHGVDPDSRKVAWARRALAGQPNVRIEEGTVEETLAGGASGRFDAAVVCDVLYLLPEPKWPGFLSTVRDLLKPSGRLLLKEVEGDGSWKHRKALAQEWVMVSLLGRTKASGGMALKPRAEMTRYLKDAGFAVREVVDLGQGYTTPHVLYVAENSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1P2</accession>
    <name>Q1D1P2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555246.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88525">
        <property type="protein sequence ID" value="ABF88525"/>
        <property type="gene ID" value="MXAN_5279"/>
    </dbReference>
    <dbReference type="GeneID" id="41362556"/>
    <dbReference type="KEGG" id="mxa:MXAN_5279"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760372_0_0_7"/>
    <dbReference type="OMA" id="KDISATC"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188124" evidence="1">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="372" mass="41056" checksum="A08349467EDCCD9C" modified="2006-07-11" version="1">MHRCLLSLSSLVLLAAGCRHANLPDLPASHGALSMAMDRYANDRESSFDNYTPAPASIFQEEPQVLVEPEQALAVYGEASATLSGTPTAQQVRDAVDDLKGACLSGLLDACVFLRERFELPRRRNEATPHFPEEVVMKQLFTVGVLRCRLALDGVLRDCTVLERGAKGVEESLLEYAMKMRYHPATLAGHPIELPYIISLQFNPARRDAPMAKVLEPRLRLEWARARAVGSPASPLAWGNLAVLLAKEGPEDGLYREALRRFQSLAPASWWAANEVAWFHIQEGQYADAAPLVKRARAFAFDNPYVLETSAAVMAGTNQCAQAVQEQRRAVEKLPAEWPAPERERFIRALEHYQRGCMAPNADSASAPTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D272</accession>
    <name>Q1D272_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M20 (Carboxypeptidase Ss1) subfamily protein</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555071.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5097"/>
    <dbReference type="EnsemblBacteria" id="ABF92271">
        <property type="protein sequence ID" value="ABF92271"/>
        <property type="gene ID" value="MXAN_5097"/>
    </dbReference>
    <dbReference type="GeneID" id="41362381"/>
    <dbReference type="KEGG" id="mxa:MXAN_5097"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_7"/>
    <dbReference type="OMA" id="MKMHACG"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188151" evidence="2">
        <location>
            <begin position="24"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="219"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="437" mass="46073" checksum="BFE49C71A7B0A261" modified="2006-07-11" version="1">MKISPLLPLLLISLAAPGGLALAAETPPVLGGLDAIYPELDALYRDLHQTPELSNQEAKTAAKLADRLRKLGFEVTSKVGGHGVVALLRNGQGPTVMLRADMDALPVEEKTGLPYASKQKAKDAAGATHPVMHACGHDVHMTSLLGTAALLARSKDRWRGTLLLVGQPAEEVGAGARQMLQDGLFKRFPKPDFAVALHVNTAAAGTVEFTPGYAMASVDGVEITLHGKGGHGAYPHTTVDPVVMAARVVLSLQTLVSREKNPLEPAVVTVGSIHGGAKHNIIPDDVKLHLTVRSYKPEVRKALLDGIERIAKAEAMASGAPRPPDIAITEGTPSTFNDPALTKRLVGAVSRVLGEKNLQEAPPVMGGEDFSEYGRAGVPAVMLWLGSTEPRQYAQAMSAGTALPSMHSPLFAPDRERTLRTGVTTLTTAALELLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F9</accession>
    <name>Q1D2F9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554985.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5009"/>
    <dbReference type="EnsemblBacteria" id="ABF87868">
        <property type="protein sequence ID" value="ABF87868"/>
        <property type="gene ID" value="MXAN_5009"/>
    </dbReference>
    <dbReference type="GeneID" id="41362293"/>
    <dbReference type="KEGG" id="mxa:MXAN_5009"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014010_0_0_7"/>
    <dbReference type="OMA" id="ADIMVNS"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="615" mass="67494" checksum="715A496DAAE4C298" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2L3</accession>
    <name>Q1D2L3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2063 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4954"/>
    <dbReference type="EnsemblBacteria" id="ABF86657">
        <property type="protein sequence ID" value="ABF86657"/>
        <property type="gene ID" value="MXAN_4954"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4954"/>
    <dbReference type="eggNOG" id="COG3219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150888_0_0_7"/>
    <dbReference type="OMA" id="FEWTDFA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018640">
        <property type="entry name" value="DUF2063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044922">
        <property type="entry name" value="DUF2063_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09836">
        <property type="entry name" value="DUF2063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2063" evidence="2">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="31266" checksum="DB296EABE242D115" modified="2006-07-11" version="1">MVALPLRAGAHRPGGDARRVGPGPPFPGRGAGRGGHCASIAAGGRRPMKPSLRDFFDSMGDYLAEPGPESLAALYARHPGWEAPRERVSLYGGFVLGHVRSALDKVFPLTRQALGQDAWDDLVVAFTRTRPARHHELNHLCEGFPAFLADAAASRGLAPFVPALARFEWTDFAVFASLEPSPERVERLMANPTLVVLEHDFHLCAYVRARGAATSPEAGAELALLWRHPEQLKTLYMAATPPALLVLKMAVEGLALADVVAATGMAEADLRATVTRFGRDGLVLLPDDSDGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D386</accession>
    <name>FABZ_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="1">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name type="ordered locus">MXAN_4725</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554712.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D386"/>
    <dbReference type="SMR" id="Q1D386"/>
    <dbReference type="STRING" id="246197.MXAN_4725"/>
    <dbReference type="EnsemblBacteria" id="ABF91809">
        <property type="protein sequence ID" value="ABF91809"/>
        <property type="gene ID" value="MXAN_4725"/>
    </dbReference>
    <dbReference type="GeneID" id="41362024"/>
    <dbReference type="KEGG" id="mxa:MXAN_4725"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_0_7"/>
    <dbReference type="OMA" id="HFPHEPV"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000340790" description="3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <sequence length="153" mass="16734" checksum="D90A428DD2120FF7" modified="2006-07-11" version="1">MDIGEILNLLPHRYPFLLVDRVVEIIPGQKLTAYKNVTINEPFFNGHFPGHPVMPGVLILEALAQATAILAYKSENMDPSRKLTYLMGVDGARFRKPVLPGDRLQLEIEVVRHKGAVWKTKGLATVDGARVAEGEFLATVVDKDADAAESAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M3</accession>
    <name>Q1D3M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554577.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4582"/>
    <dbReference type="EnsemblBacteria" id="ABF88424">
        <property type="protein sequence ID" value="ABF88424"/>
        <property type="gene ID" value="MXAN_4582"/>
    </dbReference>
    <dbReference type="GeneID" id="41361882"/>
    <dbReference type="KEGG" id="mxa:MXAN_4582"/>
    <dbReference type="eggNOG" id="COG5340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089333_0_1_7"/>
    <dbReference type="OMA" id="CFKYRNK"/>
    <dbReference type="OrthoDB" id="1200118at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26876" checksum="82B55A01FDF005C0" modified="2006-07-11" version="1">MRRRPGYKSRPSVAALAESLGLLRSRDLEAHGAARSQLNLLCNVGALREVAPGVWARSSAMVTAAAIAVKRVPRGVLCLKSALWFHGLLPESPTEVWMAIGAHARKPRWDQPPLQVVRFSGRAQTEGIEHRLLWGLPITVYGVAKTVADLFKYRNKLGFPIAVRALHDALLSGLTTSDEVRHFAEICRVRKSVGPYLEVLEARRGQDILRARQAFLAREAARARSLEAPLLHQLPGHPESESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U9</accession>
    <name>Q1D3U9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554501.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4505"/>
    <dbReference type="EnsemblBacteria" id="ABF90543">
        <property type="protein sequence ID" value="ABF90543"/>
        <property type="gene ID" value="MXAN_4505"/>
    </dbReference>
    <dbReference type="GeneID" id="41361812"/>
    <dbReference type="KEGG" id="mxa:MXAN_4505"/>
    <dbReference type="eggNOG" id="COG4385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347052_0_0_7"/>
    <dbReference type="OMA" id="RYLWVRV"/>
    <dbReference type="OrthoDB" id="429362at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011748">
        <property type="entry name" value="Unchr_phage_tail-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02242">
        <property type="entry name" value="tail_TIGR02242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="806" mass="85859" checksum="7024BEF4A523CBD1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D408</accession>
    <name>Q1D408_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_4444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4444"/>
    <dbReference type="EnsemblBacteria" id="ABF89415">
        <property type="protein sequence ID" value="ABF89415"/>
        <property type="gene ID" value="MXAN_4444"/>
    </dbReference>
    <dbReference type="GeneID" id="41361756"/>
    <dbReference type="KEGG" id="mxa:MXAN_4444"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="FTTKDVW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="310"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="404"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="615" mass="66015" checksum="ED82C5DA2F3847C8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4D0</accession>
    <name>Q1D4D0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4318"/>
    <dbReference type="EnsemblBacteria" id="ABF92503">
        <property type="protein sequence ID" value="ABF92503"/>
        <property type="gene ID" value="MXAN_4318"/>
    </dbReference>
    <dbReference type="GeneID" id="41361629"/>
    <dbReference type="KEGG" id="mxa:MXAN_4318"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122700_1_0_7"/>
    <dbReference type="OMA" id="IDWANFT"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="14019" checksum="395A24F0716022CC" modified="2006-07-11" version="1">MTSSILLPLLGGALIGLSASLLLLANGRVAGISGVVGSLLAPVRGDVAWRVLFFAGLLAGGLLLAWLRPGSFPAPSTPGAGGLWLLVGAGLLVGFGSRLGNGCTSGHGVCGISRGSVRSISATLTFMATGVLTVFLVRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4D3</accession>
    <name>Q1D4D3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554318.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4315"/>
    <dbReference type="EnsemblBacteria" id="ABF91871">
        <property type="protein sequence ID" value="ABF91871"/>
        <property type="gene ID" value="MXAN_4315"/>
    </dbReference>
    <dbReference type="GeneID" id="41361626"/>
    <dbReference type="KEGG" id="mxa:MXAN_4315"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118355_0_0_7"/>
    <dbReference type="OMA" id="CSPEWNE"/>
    <dbReference type="OrthoDB" id="2014333at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="253" mass="27355" checksum="9FD8796290927E7E" modified="2006-07-11" version="1">MEACSPQWQERLSAWFDGEVQAHEQQAVAHHLSRCAGCAREAARYASLRQALRAEGSAEQQVPPELEERVTRLVTRPRPSFPRRRLAAGLAAVLASVGVLWTSWPSGMNEALAMDLERHHLKAFSRIAPCEFESSDPAEVKAWVEREVGYPVDVPVVPGATLLGARRCRLHGKLSASLLYRHEEGKAMTLFLPLPGSAAAQEAARFAGDGPRCTQGPVGERICVLPGGGERAALAVSEMEPAVLLAALARLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4E5</accession>
    <name>Q1D4E5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554306.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4303"/>
    <dbReference type="EnsemblBacteria" id="ABF88140">
        <property type="protein sequence ID" value="ABF88140"/>
        <property type="gene ID" value="MXAN_4303"/>
    </dbReference>
    <dbReference type="GeneID" id="41361614"/>
    <dbReference type="KEGG" id="mxa:MXAN_4303"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047974_0_0_7"/>
    <dbReference type="OMA" id="LPHLDYC"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="461" mass="51522" checksum="7EB4C11FD32782A7" modified="2006-07-11" version="1">MERCVVLDLPGLSARYVGPSAPNMQAFVERGRMVPLQPVLPALNCTMQATFLTGRYPSEHGIVGDGWLNRELGEVRFWPQSDGLVQTPQLWDAARKLDPSFTCARVCWFMNMYSKADYAITPQPSFTADGRVVPDVFTEPLHLRKPLVEALGNFPAYDYWGPRYSIRSSEWIADVAMWLEQRHSPTLSLVFLPHLDYTPHTFGPNAKEIHKSLREIDDVVGKLIGFYESRGVRVIILSEFGAVPVSRAVHLNRLFRRRGWLAIREEGGRDVVYPSGSEAFAVADMQIAHIYVRNPALLDEVKALVEAEPGVAQVLDAEGKRAHHLDHPRSGELVALAEPDAWFTYFYWLDDARAPDYARTVDIYRKPGYDPLEMFVDPKLGLRMLELGGSVVKEKLGVRSRLEVVSMDGSLLKGAHGLPTGPEDGPVLMTRHGELIEAETLHATQVHDLILAHLTGQQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4N4</accession>
    <name>Q1D4N4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554217.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4214"/>
    <dbReference type="EnsemblBacteria" id="ABF86256">
        <property type="protein sequence ID" value="ABF86256"/>
        <property type="gene ID" value="MXAN_4214"/>
    </dbReference>
    <dbReference type="GeneID" id="41361531"/>
    <dbReference type="KEGG" id="mxa:MXAN_4214"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_1_0_7"/>
    <dbReference type="OMA" id="NDQMLHP"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30474" checksum="4FE3FBE5CD795FAA" modified="2006-07-11" version="1">MPFEVRFWGVRGSIPSPGAHTKRYGGNTPCVEVRCGDELLIFDLGTGARALGHALVAKKKPVKGSIFISHYHYDHLQGLPFFGPMYLPTSDLTVYGPARHGQSVKQLLSGQMVPPYFPVTADGVFRAQLTYTDLAATQTLKLGPATVHTIELNHPGGNMGYRVECQGRSVVYATDLEHGSDMDAAFYAFAQDADVLIYDAMYTEDEYHGRTGPARTGWGHSTWQAAVHAADEAGVKKLVLFHHDPSRDDAGMDRLLRQVRKHRPDAIAARESLVIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4N9</accession>
    <name>Q1D4N9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4209"/>
    <dbReference type="EnsemblBacteria" id="ABF88596">
        <property type="protein sequence ID" value="ABF88596"/>
        <property type="gene ID" value="MXAN_4209"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4209"/>
    <dbReference type="eggNOG" id="ENOG5033DWT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2130758_0_0_7"/>
    <dbReference type="OMA" id="TENTTMH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021521">
        <property type="entry name" value="DUF3185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11381">
        <property type="entry name" value="DUF3185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="12206" checksum="EACACE728F003B9D" modified="2006-07-11" version="1">MPRSQRRLREPRRRRRLRGERSAETDAGLLLQGRPVTSGGNVSFVRLLGVMLAIAGAVLLWSGLKARDSLAERATELITGRNTDRTTLYLAGGGAALVGGILMVLAGGGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D564</accession>
    <name>Q1D564_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554039.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4030"/>
    <dbReference type="EnsemblBacteria" id="ABF87943">
        <property type="protein sequence ID" value="ABF87943"/>
        <property type="gene ID" value="MXAN_4030"/>
    </dbReference>
    <dbReference type="GeneID" id="41361361"/>
    <dbReference type="KEGG" id="mxa:MXAN_4030"/>
    <dbReference type="HOGENOM" id="CLU_330609_0_0_7"/>
    <dbReference type="OMA" id="GLEGQPY"/>
    <dbReference type="OrthoDB" id="237402at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188377" evidence="1">
        <location>
            <begin position="25"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="871" mass="90605" checksum="2BC3E70CD0F429E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D585</accession>
    <name>Q1D585_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554018.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88122">
        <property type="protein sequence ID" value="ABF88122"/>
        <property type="gene ID" value="MXAN_4008"/>
    </dbReference>
    <dbReference type="GeneID" id="41361339"/>
    <dbReference type="KEGG" id="mxa:MXAN_4008"/>
    <dbReference type="HOGENOM" id="CLU_1233935_0_0_7"/>
    <dbReference type="OMA" id="GYSFRPP"/>
    <dbReference type="OrthoDB" id="1425673at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="23758" checksum="5FCA75BA33685C75" modified="2006-07-11" version="1">MHATFLAVGLLTLPGALGTELRRDGYSFRPPKGFHMVRWEQYAGSRVGAVALDPDAPRALSAALTDGDGPDAATLLVSVVGRGFSASPSDREEFASAVMQHYQRELGLSLAAERVERLGGVTPRVEVLGTLREAGQVRTVLVAGLASEGEHAVVMVSAPAVRWQALEPQVRASLETFRHEPPSAGGPVPRRVLGALAGTLAGALVVSYTAWRRRRLRHAAGNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5E8</accession>
    <name>Q1D5E8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide TA biosynthesis protein TaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">taF</name>
        <name evidence="4" type="ORF">MXAN_3945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553955.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3945"/>
    <dbReference type="EnsemblBacteria" id="ABF92623">
        <property type="protein sequence ID" value="ABF92623"/>
        <property type="gene ID" value="MXAN_3945"/>
    </dbReference>
    <dbReference type="GeneID" id="41361277"/>
    <dbReference type="KEGG" id="mxa:MXAN_3945"/>
    <dbReference type="eggNOG" id="COG3425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_3_2_7"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="79"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="276"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="45561" checksum="63CE09A7A163BC3F" modified="2006-07-11" version="1">MAERVPGGVGIEAINAYGGAASIPVLDLFRGRRLDPERFSNLMMQERGVALPFEDPVTNAVNAARPILDAMSPEARERIELLVTSSESGVDFSKSISSYAHEHLGLSRHCRFLEVKQACYAATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYSEPAMGTGGVAVLLGDEPRVMKMDLGAFGNYSYDVFDTARPSPEIDIGDVDRSLFTYLDCLKHSFAAYGRRVDGVDFVSTFDYLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYLSLCSIIDTIKPERSARVGMFSYGSGCSSEFFSGVIGPESVSALAGLDIGGHLRGRRQLTFDQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRMLALRRVVDYHRQYEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5H6</accession>
    <name>Q1D5H6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase, large subunit</fullName>
            <ecNumber evidence="17">1.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MXAN_3917</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.-.-" evidence="17"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553927.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3917"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="ABF89803">
        <property type="protein sequence ID" value="ABF89803"/>
        <property type="gene ID" value="MXAN_3917"/>
    </dbReference>
    <dbReference type="GeneID" id="41361248"/>
    <dbReference type="KEGG" id="mxa:MXAN_3917"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_7"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="OrthoDB" id="5568at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1499"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABF89803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1521" mass="165719" checksum="866A99408D127AAB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5T2</accession>
    <name>Q1D5T2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA 3'-terminal phosphate cyclase</fullName>
            <ecNumber evidence="2">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rtcA</name>
        <name evidence="10" type="ORF">MXAN_3809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553821.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3809"/>
    <dbReference type="EnsemblBacteria" id="ABF86055">
        <property type="protein sequence ID" value="ABF86055"/>
        <property type="gene ID" value="MXAN_3809"/>
    </dbReference>
    <dbReference type="GeneID" id="41361140"/>
    <dbReference type="KEGG" id="mxa:MXAN_3809"/>
    <dbReference type="eggNOG" id="COG0430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_7"/>
    <dbReference type="OMA" id="FQCLVYP"/>
    <dbReference type="OrthoDB" id="1293293at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="8">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="9">
        <location>
            <begin position="194"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="360" mass="37677" checksum="125C932279EC1E20" modified="2006-07-11" version="1">MTGTQGPDTGLVRLDGSEGEGGGQILRSALSLSLITGRPFHITRLRERRDPPGLRPQHLACVRGAEALCGGAAFSEGATVGASELSFTPAPVRAGDYLLEVGTAGSTPLLFQCLVYPLALAGGGRLTLRGGTHLPHSPSFHYVATVWQPVAHAYGLPVLLSLVHAGFYPEGAGEIVAEVGPPQEPPRLVELPARGMLREVRVSSFTGGLPFTIAERQSRAAVGALRERGILAEADNRPLAVTRSVGTVTFVLAQFEHTIAGFTALGERGRPAEDVGREGGEALARFMETGGALDEHLADQILLPAALLAAGRLGPASPGTTRFTAARITDHLTTHARVVERFLPVRVTVDAGGSVEVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5X4</accession>
    <name>Q1D5X4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553780.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3767"/>
    <dbReference type="EnsemblBacteria" id="ABF90903">
        <property type="protein sequence ID" value="ABF90903"/>
        <property type="gene ID" value="MXAN_3767"/>
    </dbReference>
    <dbReference type="GeneID" id="41361099"/>
    <dbReference type="KEGG" id="mxa:MXAN_3767"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041431_0_0_7"/>
    <dbReference type="OMA" id="KEPDKFQ"/>
    <dbReference type="OrthoDB" id="1165486at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="4">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="27808" checksum="F8CBE841546EA460" modified="2006-07-11" version="1">MAGTTKTEKIRQKELSQPDSFQKVGTEASDWLAQRQKIIGLAAGVLILGGVGVAIASEVSKRGEEKASQALGQALTVLDRPVEGVEPAQPGDTEPPFKSVKERDEAVVKSLGEFRQQHGGTPAAVTAALAEGKAQFRLGNYAAAQTAFGEYLKGAAQNDPLRAEAFEGQGYALEADGKYEDAIKAFEQMGAAGGPFLVGMGDYHKARMLILLGKKEEAAQVLSKLTTTQPNTAAARQAGERLAVLASEGVKVPAPEAPAAAPVPDAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6E2</accession>
    <name>RL35_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">MXAN_3592</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553617.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6E2"/>
    <dbReference type="SMR" id="Q1D6E2"/>
    <dbReference type="STRING" id="246197.MXAN_3592"/>
    <dbReference type="EnsemblBacteria" id="ABF90705">
        <property type="protein sequence ID" value="ABF90705"/>
        <property type="gene ID" value="MXAN_3592"/>
    </dbReference>
    <dbReference type="GeneID" id="41360938"/>
    <dbReference type="KEGG" id="mxa:MXAN_3592"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_2_1_7"/>
    <dbReference type="OMA" id="LRDMDAK"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000258710" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="68" mass="7737" checksum="5C1BD2AE836BCB82" modified="2006-07-11" version="1">MPKLKTRSSAKKRFDVKKSGKVKHGKAFAKHLFTFSKTPKSKRSNRGTGHLRDMDAKKVIKEMFPYGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P1</accession>
    <name>CYSC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysC</name>
        <name type="ordered locus">MXAN_3487</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553518.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6P1"/>
    <dbReference type="SMR" id="Q1D6P1"/>
    <dbReference type="STRING" id="246197.MXAN_3487"/>
    <dbReference type="EnsemblBacteria" id="ABF86456">
        <property type="protein sequence ID" value="ABF86456"/>
        <property type="gene ID" value="MXAN_3487"/>
    </dbReference>
    <dbReference type="GeneID" id="41360834"/>
    <dbReference type="KEGG" id="mxa:MXAN_3487"/>
    <dbReference type="eggNOG" id="COG0529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_2_1_7"/>
    <dbReference type="OMA" id="GVTIWFT"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="BRENDA" id="2.7.1.25">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000057445" description="Adenylyl-sulfate kinase">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <sequence length="185" mass="19866" checksum="669D50AD0AB6080C" modified="2006-07-11" version="1">MGRSAGFILWLTGLSGAGKSTLSRALRAHLASSMPVEVLDGDEVRTWLSRGLGFTREDREENVRRIGHVARLLAKHGVGVIAAAISPYASSRAEVRRLAEEAGIPFVEIYVQAPLDVLIARDVKGLYKKALAGELAHFTGVSDPYEAPDAPDVTVHSDVDTVEAGLWRVLETLRKRGLLDAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6S1</accession>
    <name>Q1D6S1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553488.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3455"/>
    <dbReference type="EnsemblBacteria" id="ABF86039">
        <property type="protein sequence ID" value="ABF86039"/>
        <property type="gene ID" value="MXAN_3455"/>
    </dbReference>
    <dbReference type="GeneID" id="41360803"/>
    <dbReference type="KEGG" id="mxa:MXAN_3455"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_4_2_7"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="38823" checksum="6DBD200B089E9248" modified="2006-07-11" version="1">MSVIQAALGKARVQRASGDLEGAAATLDAVAWQAREDVLPMLQDVLEQLTVIENGFVFRYVPAGTFIMGSDDGEPDERPAHAVTLSAFWMSDTSLSWSAFARLLDWPEPPEFPTDEQLDGFTDSFAYFNDSKIRLQYCENDTLQASDWHAHAIHTRWETGDGVIKTSQELFGTPARAGEGPLRYDQKPMVAVAPSLAEQFARRLSTPSVTYRLPTEAEWERAARGCFRGAAYPWGNEPPDASRADFDRFNDFSLRPMRAFPPNDYGLFGMAGGVSQWCQDHYDAEYYRHSPKTSPVCVLGEDIPKRTHVLRGGSWADCADALRVSFRSASDTGAAPNIGFRLVRVPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6V4</accession>
    <name>Q1D6V4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553455.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3422"/>
    <dbReference type="EnsemblBacteria" id="ABF87053">
        <property type="protein sequence ID" value="ABF87053"/>
        <property type="gene ID" value="MXAN_3422"/>
    </dbReference>
    <dbReference type="GeneID" id="41360769"/>
    <dbReference type="KEGG" id="mxa:MXAN_3422"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_7"/>
    <dbReference type="OMA" id="IEKTGYE"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="761" mass="78659" checksum="2A32FBFF28BB0758" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7I2</accession>
    <name>Q1D7I2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3190"/>
    <dbReference type="EnsemblBacteria" id="ABF87834">
        <property type="protein sequence ID" value="ABF87834"/>
        <property type="gene ID" value="MXAN_3190"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3190"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097656_0_0_7"/>
    <dbReference type="OMA" id="ARRVTWD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="27846" checksum="11C4BA1E787947A5" modified="2006-07-11" version="1">MGAMSPPEPFPLYHPADVRRAFSSDDATRRFAKVAQLEPGSRVLVLGCGPDGSAALLLAREMGCTVVAADTDDALLNPVRERVRAQGLAEQIEVRRVSLDALGLSDGEFNGILIQGRVLYALKATLANMRSLLSKRGRLGFTFPARVGRFAPKASLDFWERRIAGPLLLPRELLQVVEGAGYEPESAESLHDAELDAHYRDIETFLSSVPGSQPAALREELALHRESNGKASVSYAFVVGRRKEQGEKPPASRDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7V6</accession>
    <name>Q1D7V6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553114.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3059"/>
    <dbReference type="EnsemblBacteria" id="ABF93129">
        <property type="protein sequence ID" value="ABF93129"/>
        <property type="gene ID" value="MXAN_3059"/>
    </dbReference>
    <dbReference type="GeneID" id="41360421"/>
    <dbReference type="KEGG" id="mxa:MXAN_3059"/>
    <dbReference type="eggNOG" id="COG2210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144610_0_0_7"/>
    <dbReference type="OMA" id="WEDRYQA"/>
    <dbReference type="OrthoDB" id="1763515at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="130" mass="14000" checksum="71CF287DDB99A85B" modified="2006-07-11" version="1">MAGRVLFFLQHATYEPAFQAATMGITAAAMGDEVYFVFAFDALRQLVGGAYGQPSSAREHEEFARAESLGVLAPPHMLAEARTLGARLIACDTTVRICGYEPESLEGTLDEVMGMASIWRLTAGARVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7X2</accession>
    <name>Q1D7X2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gcvP</name>
        <name evidence="9" type="ORF">MXAN_3042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF89308">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="971" mass="104863" checksum="E8AC91493069E6A0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D878</accession>
    <name>Q1D878_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_2934"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="33" mass="3811" checksum="E46A66DC1F9D706F" modified="2006-07-11" version="1">MRFGERISNPALHSVYNSARLASLENRELDLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8A3</accession>
    <name>Q1D8A3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_2909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="gene ID" value="MXAN_2909"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2909"/>
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    <dbReference type="OrthoDB" id="1913149at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14536" checksum="B174ACA0780D8B05" modified="2006-07-11" version="1">MCTLRSYLQLPRRHPVNSQDFEGTMTSAARPSGRAPGLRVIKGEGRRREEPLASRDAVARVLMEAGADLLLRRISPARAGEIERKVDRVLDLFDRVDVAPVLMPVLKRHLDELEALMRETREVRAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8E1</accession>
    <name>Q1D8E1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF85943">
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        <property type="gene ID" value="MXAN_2871"/>
    </dbReference>
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    <dbReference type="OMA" id="HWFGGKE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF85943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="20855" checksum="3F569AC927A5C945" modified="2006-07-11" version="1">MPSTRPPTAKPAVRQRDSERTRTALMTAARALFSTQGFANTGVRDIAALAGVNSSLVGRYFGSKQGLYRETLAQVLDIGPLLQIDRRQFGETVVSLFLGAHDASGPLAMLILSASDPEAHATSVELLQKQVIAPLARWLGAPDGEGRAARLNILWNGLLVSGRLLPIQRLSEGLDTSTQRWLAAAIQSVIDEGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D929</accession>
    <name>Q1D929_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2625"/>
    <dbReference type="EnsemblBacteria" id="ABF86224">
        <property type="protein sequence ID" value="ABF86224"/>
        <property type="gene ID" value="MXAN_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2625"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2491012_0_0_7"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="87" mass="9710" checksum="70E0FA19ED531841" modified="2006-07-11" version="1">MGPMIPEDIDLQQLTADLKNALGPGEPIGYLRGKSVMRNLLVDMRGFSQLEAEELIDTMETRGFLRFLGDPTERSVAEAHWDISPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D932</accession>
    <name>Q1D932_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">MXAN_2622</name>
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    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2622"/>
    <dbReference type="EnsemblBacteria" id="ABF90260">
        <property type="protein sequence ID" value="ABF90260"/>
        <property type="gene ID" value="MXAN_2622"/>
    </dbReference>
    <dbReference type="GeneID" id="41359999"/>
    <dbReference type="KEGG" id="mxa:MXAN_2622"/>
    <dbReference type="eggNOG" id="COG3361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102511_0_0_7"/>
    <dbReference type="OMA" id="HFLTARW"/>
    <dbReference type="OrthoDB" id="1231841at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28739" checksum="91D35B381AF70D8D" modified="2006-07-11" version="1">MRPFLTAEWRYLVMLNYEVDPEVLRPLVPRDTELDTWQGRTFASMVGFRFLDTRVRGLPVPFHRNFDEVNLRFYVRHLGPEGWRRGVVFVKEIVPRQAIATVARVLYNEPYVALPMRHVVEMEGAHTGAPGRVEYAWKAGGKWQHLAATTLGPPQASEPGSAAEFITEHYWGYTAQRDGGCAEYRVEHPRWSVWQVDTTALEIDVEGMYGARFVPFLRGKPSSAFVADGSAVAVYPGTRTGSGASQSPASEKPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D957</accession>
    <name>Q1D957_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2597"/>
    <dbReference type="EnsemblBacteria" id="ABF92211">
        <property type="protein sequence ID" value="ABF92211"/>
        <property type="gene ID" value="MXAN_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2597"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073040_0_0_7"/>
    <dbReference type="OMA" id="IKMGSYS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="27976" checksum="5746C1C43581E0ED" modified="2006-07-11" version="1">MKVWRRVLERRLRTRLRAKVALEIHDNTHTMLTFQRQRAMWRLRLHHMFLVAPDDVVQALASFVRKGDPDASVLLDKFIERNRVYIRRLSPAQMRKRIRLEPVGQHHDLERIYARLNERYFEGRIDAAITYGPAPRVKGPRKSIKMGSYSADSKVIRIHPALDQPVVPRYFVEWIVFHEMLHHVYRTRKGEDGRRCIHPPELMEHEKQFHDYARALAWERENLDLLLRARVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9N3</accession>
    <name>Q1D9N3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552495.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2420"/>
    <dbReference type="EnsemblBacteria" id="ABF90683">
        <property type="protein sequence ID" value="ABF90683"/>
        <property type="gene ID" value="MXAN_2420"/>
    </dbReference>
    <dbReference type="GeneID" id="41359804"/>
    <dbReference type="KEGG" id="mxa:MXAN_2420"/>
    <dbReference type="eggNOG" id="COG5337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468429_0_0_7"/>
    <dbReference type="OMA" id="HQGVYVE"/>
    <dbReference type="OrthoDB" id="160274at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188400" evidence="2">
        <location>
            <begin position="25"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="601" mass="68480" checksum="E5D80551A89AEFE9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9T7</accession>
    <name>Q1D9T7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2366"/>
    <dbReference type="EnsemblBacteria" id="ABF89254">
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        <property type="gene ID" value="MXAN_2366"/>
    </dbReference>
    <dbReference type="GeneID" id="41359751"/>
    <dbReference type="KEGG" id="mxa:MXAN_2366"/>
    <dbReference type="eggNOG" id="COG3258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029768_0_0_7"/>
    <dbReference type="OMA" id="PQWVWST"/>
    <dbReference type="OrthoDB" id="1025062at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="543" mass="57137" checksum="E7F111E686ED7206" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG9</accession>
    <name>Q1DAG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2130"/>
    <dbReference type="EnsemblBacteria" id="ABF91752">
        <property type="protein sequence ID" value="ABF91752"/>
        <property type="gene ID" value="MXAN_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2130"/>
    <dbReference type="HOGENOM" id="CLU_1925327_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="13816" checksum="D1D8F56BCBEAC475" modified="2006-07-11" version="1">MVRPRAPPSCATSSRGPGGTDPSQLTVWKERLYFVVSLPWGGITLYVSDGTAAGTLPHAVIAPEGQGGRSTWTPPSPRATGCACRWCRAASGRRTSGVGWHEGEGHQLAAEAVEFGVQVVAHHVFLGLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK1</accession>
    <name>Q1DAK1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552177.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2094"/>
    <dbReference type="EnsemblBacteria" id="ABF87285">
        <property type="protein sequence ID" value="ABF87285"/>
        <property type="gene ID" value="MXAN_2094"/>
    </dbReference>
    <dbReference type="GeneID" id="41359500"/>
    <dbReference type="KEGG" id="mxa:MXAN_2094"/>
    <dbReference type="HOGENOM" id="CLU_112468_0_0_7"/>
    <dbReference type="OMA" id="APRERIW"/>
    <dbReference type="OrthoDB" id="1728259at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045506">
        <property type="entry name" value="DUF6484"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20093">
        <property type="entry name" value="DUF6484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6484" evidence="1">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="19006" checksum="BF0238B081B86ECD" modified="2006-07-11" version="1">MSMPVGRPHAEPLGDAPRERIWGSRLGWLTGVDDNGRFLVDFGGNTEGPLPAKRTINLTSEVVRAAVATRQFAVLLFEDGDPRLPLVIGLEQGHSSTPLLDVMLDTAGIEPEPVPAPTEARVDGQRVEIEGKDEIVLRCGQASITMRSNGKVVIRGVYVETQSSGVNRIKGGSVQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY1</accession>
    <name>Q1DAY1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">MXAN_1954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552047.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1954"/>
    <dbReference type="EnsemblBacteria" id="ABF89936">
        <property type="protein sequence ID" value="ABF89936"/>
        <property type="gene ID" value="MXAN_1954"/>
    </dbReference>
    <dbReference type="GeneID" id="41359367"/>
    <dbReference type="KEGG" id="mxa:MXAN_1954"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_7"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="320" mass="34625" checksum="84A3FA201442F500" modified="2006-07-11" version="1">MAEEKINKVTIIGSGPAGYTAAIYAARANLQPVVFAGGPTLEHPQRVPGGQLMVTTDVENYPGFPEAITGPELMDRFQKQAERFGTTIHMENVVKVDFSQRPFLIQGESVSCRSETVIISTGATAKWLGVKGEDTYKNRGVSACATCDGAFFKKQDVLVVGGGDTAMEEATYLAKIVNHVTLIHRRDTLRASKVMQERARQNPKISFMWDSAVEEVLGDAKGMNGAVVRNLKTGDSQQVKATGLFVAIGHTPNTELFQGVLETHQGGYLKTVPGSTRTNIEGVFACGDVQDHYYRQAITAAGTGCMAAIDAERWLIEHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE0</accession>
    <name>Q1DBE0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1785"/>
    <dbReference type="EnsemblBacteria" id="ABF88429">
        <property type="protein sequence ID" value="ABF88429"/>
        <property type="gene ID" value="MXAN_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1785"/>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420118_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="106"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="191" mass="20517" checksum="511B2BD454A47DF6" modified="2006-07-11" version="1">MERFLSPRSPPTTSLSEPPNVGMAAPKNTACACMLTSKCWGLHLAPRDSERRGAAQAMVRRESHSDFGQLPVRGERAELADVVAGASGGAEHLGQARLLAPSVDVEECAPAVRVEAQAREADVVRTAVRQLHSAPVLAQLRTWLEAQAPRHPPKSPLGQAISYALTQWEALTRFVENERLPLDSNGSEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH2</accession>
    <name>Q1DBH2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoquinoline 1-oxidoreductase, alpha subunit</fullName>
            <ecNumber evidence="3">1.3.99.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorA</name>
        <name evidence="3" type="ORF">MXAN_1751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551860.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1751"/>
    <dbReference type="EnsemblBacteria" id="ABF91751">
        <property type="protein sequence ID" value="ABF91751"/>
        <property type="gene ID" value="MXAN_1751"/>
    </dbReference>
    <dbReference type="GeneID" id="41359181"/>
    <dbReference type="KEGG" id="mxa:MXAN_1751"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_0_7"/>
    <dbReference type="OMA" id="GHPSHVT"/>
    <dbReference type="OrthoDB" id="1819473at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047121">
        <property type="term" value="F:isoquinoline 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="16556" checksum="27FC8C01EAA4C838" modified="2006-07-11" version="1">MAAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPCIHPVGGLSGREVVTIEGLGAQGLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPSDADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBS3</accession>
    <name>Q1DBS3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551759.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1648"/>
    <dbReference type="EnsemblBacteria" id="ABF89145">
        <property type="protein sequence ID" value="ABF89145"/>
        <property type="gene ID" value="MXAN_1648"/>
    </dbReference>
    <dbReference type="GeneID" id="41359090"/>
    <dbReference type="KEGG" id="mxa:MXAN_1648"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112876_0_0_7"/>
    <dbReference type="OMA" id="SEYVLMT"/>
    <dbReference type="OrthoDB" id="1026502at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020503">
        <property type="entry name" value="Uncharacterised_Rv2561"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10851">
        <property type="entry name" value="DUF2652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="26891" checksum="3650C250A73BA208" modified="2006-07-11" version="1">MAIEKALLLIADIGGYTRFMSHHRFSLAHAQETVAQLLEAVIDASGPLKLAKLEGDAAFFYAVGDDFPAFARMVADIRRAFVSRREQFIADRMCKCDGCMQVSSLTLKFVAHAGEVAFQRVKHLTELAGVDVILVHRMLKNDVPVTEYVLMTDAVHQGLAPELRQLTQGLEHDFEGMGRTATHYLDLNAFVLAAPEPVRPSLPRKLWAKLKLELSSMKYVLGLKQPCENFRNVEVVDAQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBU5</accession>
    <name>Q1DBU5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551737.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1626"/>
    <dbReference type="EnsemblBacteria" id="ABF86492">
        <property type="protein sequence ID" value="ABF86492"/>
        <property type="gene ID" value="MXAN_1626"/>
    </dbReference>
    <dbReference type="GeneID" id="41359071"/>
    <dbReference type="KEGG" id="mxa:MXAN_1626"/>
    <dbReference type="HOGENOM" id="CLU_1341384_0_0_7"/>
    <dbReference type="OMA" id="WTYYNDY"/>
    <dbReference type="OrthoDB" id="1854836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="203" mass="22019" checksum="DCEC0B902E864535" modified="2006-07-11" version="1">MSLLDDLLKKGSLHTPCGTAARRAALKAKLTNSGATEVVSGDLKLSEGDDRVLEASRVVVKGNLVLEDQSRLLVAGDLEVEGSIIHEGFDYALLFTGGALSAKNLLFHGELVSLGPITVQQVAWTYYNDYSTYSDSLKARIVVAADRFDAVDDVQADHHFNGHPSDIREALAKQLSADVVDADGDWSYEEIAKHLLRGRALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX3</accession>
    <name>Q1DBX3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein, ABC-2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551709.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1598"/>
    <dbReference type="EnsemblBacteria" id="ABF92963">
        <property type="protein sequence ID" value="ABF92963"/>
        <property type="gene ID" value="MXAN_1598"/>
    </dbReference>
    <dbReference type="GeneID" id="41359043"/>
    <dbReference type="KEGG" id="mxa:MXAN_1598"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_0_7"/>
    <dbReference type="OMA" id="GVWFSLE"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="36485" checksum="12428255022CD844" modified="2006-07-11" version="1">MNALGQLVLMRLRMLMRQPEVLFWTFIFPVVTSLFLGLAFRNDSLGPVRVAVAEGAGAPALMAKLEGVPELSAEVVDEASARRRLARGQLSLVLLPGAVPEALVDPSQAEGRTARLLVEQALAAPEDAARPAVVKATPVSEPGNRYVDFLIPGLLGLSLMSSSLWVVAGSLVAMRGGKLLKRLAATPMRRSQFFLSYMLARAGFALAEILFFCAFARWLFGVPMFGSYFTLTLVGLAGALCFAALGVLVASRARTEEAVGGLVNLVSLPMMFVSGVFFAAGNFPSWLQPVIRALPLTAINDSLRAVMLEGAGLASLGAPMLVLAAWTVVPLLLALRWFRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ2</accession>
    <name>Q1DBZ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551690.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1579"/>
    <dbReference type="EnsemblBacteria" id="ABF89569">
        <property type="protein sequence ID" value="ABF89569"/>
        <property type="gene ID" value="MXAN_1579"/>
    </dbReference>
    <dbReference type="GeneID" id="41359024"/>
    <dbReference type="KEGG" id="mxa:MXAN_1579"/>
    <dbReference type="eggNOG" id="COG1238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125997_0_0_7"/>
    <dbReference type="OMA" id="MEAFFDW"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="16192" checksum="FC858BA1316FF8E0" modified="2006-07-11" version="1">MPDPSVLATWGLPGLFLVAMLAGSVVPVPSEALLAALVYGGTAPVTAIGVATTGNVLGALSLYVLGRWVAGGGGGALGRWYARRREKEGPRMQRVEAWTRKWGAPALIMSWMPVVGDAFVIAGGMLGVRPLPFVFFVTLGKGLRYLAVALSAAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC05</accession>
    <name>Q1DC05_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551677.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1566"/>
    <dbReference type="EnsemblBacteria" id="ABF91183">
        <property type="protein sequence ID" value="ABF91183"/>
        <property type="gene ID" value="MXAN_1566"/>
    </dbReference>
    <dbReference type="GeneID" id="41359011"/>
    <dbReference type="KEGG" id="mxa:MXAN_1566"/>
    <dbReference type="eggNOG" id="ENOG502ZCEQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661932_0_0_7"/>
    <dbReference type="OMA" id="ATEHMMK"/>
    <dbReference type="OrthoDB" id="399185at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="454" mass="48908" checksum="B697A443FB6A72E1" modified="2006-07-11" version="1">MSPPKIGFRAPARPTELREPPRPARNEVKPQAKAQVTRPGMSGVSQFESPPARQQPVALNAPAALARGPSVAPGSYPTAADVRNIAAMQDPVARNHAITQGYSDLSNAMGQLLGTENANWSTFATWASKQAGVSIRGEDMPKFFTDALKGADGVMGPMSKVDDLLRKLGLPSLPLGDIASAGNQALQNVSKAIADGNKLVFEEVGQEFARFVETFQGDTQYDAAKAEQYLSGFPADKPLLKEAFGHYAQAMFEKDPNKKAELMLLANDKVGLHEQTQLQPYVEKALNSPVKDTFRDILKQTVEAQINALPFPANLAGKAALKTGLVDAALNPVVDGVANVFRRVATEHMMKLAVPGSALKLGNDLPPPPGMESTLFPPHLRSIENPELRALLGQLDKSQDSLKGSGAKDWSKLDQRMNYIVDLFRSRQSDPALFDPPFGQRGTYPVAPSAPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC07</accession>
    <name>Q1DC07_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ahpC</name>
        <name evidence="9" type="ORF">MXAN_1564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551675.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1564"/>
    <dbReference type="EnsemblBacteria" id="ABF91674">
        <property type="protein sequence ID" value="ABF91674"/>
        <property type="gene ID" value="MXAN_1564"/>
    </dbReference>
    <dbReference type="GeneID" id="41359009"/>
    <dbReference type="KEGG" id="mxa:MXAN_1564"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_7"/>
    <dbReference type="OMA" id="EDSESCY"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="20733" checksum="F7C255FABC898267" modified="2006-07-11" version="1">MLTVGDKIPNFKVKATVSLEKGKEFQDITNETFKGKWLVLFAWPKDFTFICPTEIAEFGKKNKDFTDRDAQVLGLSTDSEFVHHAWRTHHPDLKNLPFPMLADIKHELCNALGILHKEEGVALRATFIADPEGIIRHVTVNDLSVGRNVSETIRTLDALQTDELCPCNWTKGEETLTQKLSKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCB5</accession>
    <name>Q1DCB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein MlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551567.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1451"/>
    <dbReference type="EnsemblBacteria" id="ABF90347">
        <property type="protein sequence ID" value="ABF90347"/>
        <property type="gene ID" value="MXAN_1451"/>
    </dbReference>
    <dbReference type="GeneID" id="41358897"/>
    <dbReference type="KEGG" id="mxa:MXAN_1451"/>
    <dbReference type="HOGENOM" id="CLU_102529_0_0_7"/>
    <dbReference type="OMA" id="NTIRYEF"/>
    <dbReference type="OrthoDB" id="1657410at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="24618" checksum="6EC63BE102CC1E70" modified="2006-07-11" version="1">MTKNIVNTALVLVGAGSLLTGCNFEQPETNCFVQESPSWAVKYDVVDSPKDANGDECTTTAPLVELMGVYKYVNPETGAAQLALRPATLASRAIADTTTTSADQTSLGSLDTEPKDHGFCHANDFAPAFVNVAASDTAAANTIRYEFTNVRVYSAAVAPGTQFTGELKYTSNGCTSSYVMRAVWPPAPCDTASTEPAENCGVGSGLNPEFAVVCQPTSATGTTGYCVPAGDIPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCR7</accession>
    <name>Q1DCR7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551416.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1299"/>
    <dbReference type="EnsemblBacteria" id="ABF87215">
        <property type="protein sequence ID" value="ABF87215"/>
        <property type="gene ID" value="MXAN_1299"/>
    </dbReference>
    <dbReference type="GeneID" id="41358745"/>
    <dbReference type="KEGG" id="mxa:MXAN_1299"/>
    <dbReference type="HOGENOM" id="CLU_1473696_0_0_7"/>
    <dbReference type="OMA" id="EAWNDSE"/>
    <dbReference type="OrthoDB" id="2113639at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188491" evidence="2">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="21868" checksum="4A3C0AA466F47DD4" modified="2006-07-11" version="1">MLAMSLFRQCVFPISLAVLGSTSVLAAEKSPPPEPPAPSRKVDPTKAQTEAWLREHIEAWNDSEVHVTVKDCRIMVLDKPRERTEIVDLRGLLLPIEVIRLNGGNDATLRLRVKEKHTGTYSMFRKCSAENRYCAEPTGKFQSLPYVDLSVTSVRDFVPGRQTDVDKSLRLERALEHYSRLCGAMEDARNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDA9</accession>
    <name>Q1DDA9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ceramidase_alk domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551224.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1104"/>
    <dbReference type="EnsemblBacteria" id="ABF89232">
        <property type="protein sequence ID" value="ABF89232"/>
        <property type="gene ID" value="MXAN_1104"/>
    </dbReference>
    <dbReference type="GeneID" id="41358556"/>
    <dbReference type="KEGG" id="mxa:MXAN_1104"/>
    <dbReference type="eggNOG" id="COG3356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653501_0_0_7"/>
    <dbReference type="OMA" id="NGGYIGY"/>
    <dbReference type="OrthoDB" id="704008at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ceramidase_alk" evidence="1">
        <location>
            <begin position="67"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="436" mass="45043" checksum="A304FF00A7DF8FD9" modified="2006-07-11" version="1">MASSRLVRWRSLFPLVLLTVGAAYSLASWNWCGSWAERAPVLVSQVHGEGPLRAGAAKVALSPPFPVVVAGYTPPRPEAEQADVPLYARAVVLEAGGTQVGLVSLDLLLVPDVLATRVRERARASGLEDVLVLATHTHSSLGGYDSRLVAQVSGTGRYREDVVDAITTAAGDALAQAAASLAPVSLEVGEAREQKFVISRSGGEKPDGVLTRAVFRGQAGPVAELLLYAAHPTMVPRRRAYVDPDYPGRLSALREEAGSGVTLLLQGAGGNATVAYSEGQGLERVSGFAHALAELAGDAPLSPVGETVRLSLARADAAMPRPDASRLVPALTRAAGDNLLCESAPRLAEVGALVLGPLKLVAVPGEPSVAAGMELLQRTGATGVLSLADGYVGYVETAANVQGGLGESKRQYFGPALLERLSVAAEFVAGAAGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDM3</accession>
    <name>Q1DDM3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation efflux system protein CusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0989"/>
    <dbReference type="TCDB" id="2.A.6.1.8">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92941">
        <property type="protein sequence ID" value="ABF92941"/>
        <property type="gene ID" value="MXAN_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0989"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_1_7"/>
    <dbReference type="OMA" id="NEPLYWV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMBD" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="90"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="393" mass="42603" checksum="54E29DFC5CA13CF1" modified="2006-07-11" version="1">MGRRMLACGTTSEWRSAAPAGAHGEGDIAHYTCPMHPSVKQHGPGACPICGMDLTPVSRAELQSGIIRVDDLRRQRIGVKTAKVEQSSMDLSLRALGRVTFDEKSLVDVTLKLDGYIHELRVNATGEPVKKGDVLFTLYSPELYAAQQEYLLARQSQSAANASLVGAARKRLELWGLSAAQIERVAQRGQPVENMPFLAPASGYVLEKNVVEGAAVKAGERLFRIAPLAKVWVEADVYEQDLARVKPGHPVEVTLPYLPGKKYAGSVGYVYPSLQGATRTGRIRIELPNPELELKPDMYADVRFLLQGGAPRLQIPDSAVIYTGPRRLVFVDLGEGRLRPQEVKLGIKGNGTYEVLEGLSPGDVVVTSGNFLIAAESRIRSATDDFGGSHAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE36</accession>
    <name>Q1DE36_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550947.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0824"/>
    <dbReference type="ESTHER" id="myxxd-q1de36">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89027">
        <property type="protein sequence ID" value="ABF89027"/>
        <property type="gene ID" value="MXAN_0824"/>
    </dbReference>
    <dbReference type="GeneID" id="41358289"/>
    <dbReference type="KEGG" id="mxa:MXAN_0824"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046770_0_0_7"/>
    <dbReference type="OMA" id="AQWMTTN"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="27610" checksum="62C5E7B4EFE7CA17" modified="2006-07-11" version="1">MVLESFLVGEGDVPTVMLHGFLGTGRNLRSLAAAWSAADPSRRILLPDLTGHGTSPALPANSDLYSMARDVVDTARAQGFQGPFDWVGHSLGGRVTLAASLNVPEAVRSVSLLDIAPGPVPGDLSESGKVLGILLQAPAQAENRRAMRAELTGRGLSEPLADWLLMNLVTEESGVRWRFDRQGLAGLHSRVNDTDLWTAVERKDRPPMRCLRGGRSKYVSDADVERLVAAGCPVETLPEAGHFVHVDAPQAVLAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE90</accession>
    <name>Q1DE90_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2379 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550893.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90506">
        <property type="protein sequence ID" value="ABF90506"/>
        <property type="gene ID" value="MXAN_0767"/>
    </dbReference>
    <dbReference type="GeneID" id="41358236"/>
    <dbReference type="KEGG" id="mxa:MXAN_0767"/>
    <dbReference type="HOGENOM" id="CLU_161985_0_0_7"/>
    <dbReference type="OMA" id="RECSSRI"/>
    <dbReference type="OrthoDB" id="1942690at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011753">
        <property type="entry name" value="DUSAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09543">
        <property type="entry name" value="DUF2379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02267">
        <property type="entry name" value="TIGR02267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2379" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="14166" checksum="151325D19B7E5706" modified="2006-07-11" version="1">MAEELDWDPIRALARRVLRNGEPLMLTIEVRELLARTAREVGLSQADATSALASDTSALELLRECSRRISEGSSRMVNALHRMYQHKRAGDLDSARQEMRDVLAAEEVPHYRAVAQGQLNLLDDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEM9</accession>
    <name>Q1DEM9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550757.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0626"/>
    <dbReference type="EnsemblBacteria" id="ABF90874">
        <property type="protein sequence ID" value="ABF90874"/>
        <property type="gene ID" value="MXAN_0626"/>
    </dbReference>
    <dbReference type="GeneID" id="41358104"/>
    <dbReference type="KEGG" id="mxa:MXAN_0626"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_7"/>
    <dbReference type="OMA" id="RRITWAA"/>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="11"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="483" mass="53049" checksum="ED70537298CDF92C" modified="2006-07-11" version="1">MLEAASQANTQPTADTERIRAVFEAQRAHRWTMSRTTAAERIARLKRLREAIIARRAELADAIHADFRKPAMEVDLTELHPTLEELNHTVRHLKSWMKPMRVGTPMLLAGSSSHVRYEARGTVLLLSPWNYPFNLLVSPLVAAIAAGNTVICKPSEKTPHTSRFLAQLVKDVFPENEVALFEGGAETAEALLELPFDHIFFTGNTRIGRKVMEAAAKHLASVTLELGGKSPVIVDETADVAAAAERLCWGKFVNGGQTCVAPDYVFVHASKERAFLDALKASITRFYGGTEQERQASPDLTRLVDPVAWRRVKDLLKRSVAAGAKVEVGGETDEPSRYIAPTVLSGVTAENPVMEGEIFGPVLPVLTFQSREEVYAHIRAGGKPLALYVFSQDKRAVEDIFQNTTSGGAVVNNVLVHLANPNLPFGGVGTSGLGNYHGHFGFKTFSHERAVMVQWMKSLASVFFPPYRGKAQELASRATRLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ5</accession>
    <name>Q1DEQ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2379 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87102">
        <property type="protein sequence ID" value="ABF87102"/>
        <property type="gene ID" value="MXAN_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0600"/>
    <dbReference type="HOGENOM" id="CLU_2700912_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011753">
        <property type="entry name" value="DUSAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09543">
        <property type="entry name" value="DUF2379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2379" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="7712" checksum="657283F1CDCEDDDB" modified="2006-07-11" version="1">MRDALPTAGLFRTLALSNLPFSSSAVAHLFGEQIGELNSCVTERGALLVLCDGTRGLLRYASFEVGISPEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF32</accession>
    <name>Q1DF32_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550604.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0471"/>
    <dbReference type="EnsemblBacteria" id="ABF86041">
        <property type="protein sequence ID" value="ABF86041"/>
        <property type="gene ID" value="MXAN_0471"/>
    </dbReference>
    <dbReference type="GeneID" id="41357964"/>
    <dbReference type="KEGG" id="mxa:MXAN_0471"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2258990_0_0_7"/>
    <dbReference type="OMA" id="REMERHQ"/>
    <dbReference type="OrthoDB" id="2076660at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="11956" checksum="964B02C38E1FEF21" modified="2006-07-11" version="1">MQGDVGNDSEEVAMRRKQAWKEMWSSLFATVFPTDTLLAALRKMERHQVRLLGVVGEGGGLLGLVSEEHILAAWRGDPLAPVSGVMARAGAPGAARAGARRSRLQGAQPHGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF56</accession>
    <name>Q1DF56_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550580.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90766">
        <property type="protein sequence ID" value="ABF90766"/>
        <property type="gene ID" value="MXAN_0447"/>
    </dbReference>
    <dbReference type="GeneID" id="41357940"/>
    <dbReference type="KEGG" id="mxa:MXAN_0447"/>
    <dbReference type="eggNOG" id="ENOG5031G6Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147976_0_0_7"/>
    <dbReference type="OMA" id="KMTFVHF"/>
    <dbReference type="OrthoDB" id="2133416at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="134" mass="14931" checksum="83C4594900D3F285" modified="2006-07-11" version="1">MKPVGFIILMSLMSGCMHLRSKTPVAPPEVSAGIQFPEWTKEASTTVDGAQLKALQLAMEDFLPPGTKPPKNADAMTQCLYRIETYDAWLQRGEKMTFVHFTPREQERCGLRPEVMDPGASYAISDDGVILKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFB4</accession>
    <name>Q1DFB4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550523.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0387"/>
    <dbReference type="EnsemblBacteria" id="ABF89346">
        <property type="protein sequence ID" value="ABF89346"/>
        <property type="gene ID" value="MXAN_0387"/>
    </dbReference>
    <dbReference type="GeneID" id="41357883"/>
    <dbReference type="KEGG" id="mxa:MXAN_0387"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_4_1_7"/>
    <dbReference type="OMA" id="RSGYADQ"/>
    <dbReference type="OrthoDB" id="1757088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="284" mass="30980" checksum="77BCBCA6E85B9D5F" modified="2006-07-11" version="1">MDAMAAQGLTGCARAEDRDAMAEDAQQQGYTQWAPPIEMADAVDAFWQFWVPRKPHDVPLPRQHRVLPDGCTDLIFGFQHAPGPVWLAAPRLAVVGPMKRFILVDLEPGGVSLGVRLRPGWAQALLGVSPRELCGLNVSAQDCSPALMQFQRRMEDCASPAQAMALLQRTIARRWASFRSMAKPRAVQALGHLQASSGQVRMAALARELGVSERTLHRDILDEAGVPPKLLARVLRLQRAVSLLRSREGTDLCDVALECGYADQAHLSRDVRELAGVSPTALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFD1</accession>
    <name>Q1DFD1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lspA</name>
        <name evidence="9" type="ORF">MXAN_0368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550506.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DFD1"/>
    <dbReference type="STRING" id="246197.MXAN_0368"/>
    <dbReference type="EnsemblBacteria" id="ABF86672">
        <property type="protein sequence ID" value="ABF86672"/>
        <property type="gene ID" value="MXAN_0368"/>
    </dbReference>
    <dbReference type="GeneID" id="41357867"/>
    <dbReference type="KEGG" id="mxa:MXAN_0368"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_3_1_7"/>
    <dbReference type="OMA" id="FIEDYWH"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="198" mass="22457" checksum="2AA52BF5B28B79F6" modified="2006-07-11" version="1">MKVSHRFVLLVIVAVLAADQVTKYLAVSRLTDALDGREGLARVTGFVTEQNLDNRPPPEDGSYRVLRPYRFIEDYWHFRYVENPGAAWGIFGDMPEGVRRLFFLVVSLAAMGFIFVMYRRTPMEQRLARVALALVTGGALGNFVDRLLRGYVIDFIDWHWRNQPGMRWPTFNVADVAISVGVGLMLLDSLRAPKSPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFF5</accession>
    <name>Q1DFF5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550482.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0344"/>
    <dbReference type="EnsemblBacteria" id="ABF90576">
        <property type="protein sequence ID" value="ABF90576"/>
        <property type="gene ID" value="MXAN_0344"/>
    </dbReference>
    <dbReference type="GeneID" id="41357842"/>
    <dbReference type="KEGG" id="mxa:MXAN_0344"/>
    <dbReference type="eggNOG" id="COG1768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183887_0_0_7"/>
    <dbReference type="OMA" id="NHDYWWP"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014578">
        <property type="entry name" value="Pesterase_CT488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033094">
        <property type="entry name" value="Pesterase_CT488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26951" checksum="4F6EA707644EAB37" modified="2006-07-11" version="1">MRLFGIGDTHLPSTRQKDMHRFGWSEHPLPLQRAWDERVAPEDVVIVAGDISWATRAHEVMDDLAWLDARPGRKVLVRGNHDYWWGDSASKLRKLLEPFRTLEGFLHNNAVVMGPWVIAGSRLWTAPEAPPMPGGEMGDEAADTGYVERETRRLTASMEDAKKKEAASPTPLVRVVAVHFPPVYANEKSTAFSEPIEAFGPKVCVYGHLHAAGIAAGFTGERGGVRYVLASCDAAGFAPVLLDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFH1</accession>
    <name>Q1DFH1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen triple helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550466.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0327"/>
    <dbReference type="EnsemblBacteria" id="ABF90675">
        <property type="protein sequence ID" value="ABF90675"/>
        <property type="gene ID" value="MXAN_0327"/>
    </dbReference>
    <dbReference type="GeneID" id="41357826"/>
    <dbReference type="KEGG" id="mxa:MXAN_0327"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440678_0_0_7"/>
    <dbReference type="OMA" id="MINEQIA"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="667" mass="63025" checksum="F7D350E37E342BC4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFH6</accession>
    <name>Q1DFH6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550461.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0317"/>
    <dbReference type="EnsemblBacteria" id="ABF91931">
        <property type="protein sequence ID" value="ABF91931"/>
        <property type="gene ID" value="MXAN_0317"/>
    </dbReference>
    <dbReference type="GeneID" id="41357816"/>
    <dbReference type="KEGG" id="mxa:MXAN_0317"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096051_0_0_7"/>
    <dbReference type="OMA" id="MHLLTYL"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="264" mass="30647" checksum="32C14CC62FE82993" modified="2006-07-11" version="1">MAVLIFFVSHWLLCVFFQSFFQHRYAAHRMYTMGPKTERVMHLLTYLVQGSSYLSPKAYAILHREHHAFSDTEKDPHSPHFFKDVARMMWHTKARYDDYAAGRGQPEARFLGGYPEWPLVDTTLRTSWFATLGWVAFYSAFYVMFATSPWQFLLLPLHFLMGPVHGAIVNWCGHKYGYRNFDSTDKSRNSLPMDFLCMGELFQNNHHKYGSSPNFAARKFELDPTWQVMRVLALLRIIHIATPQRAVWPEAREAARTGGAARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFI5</accession>
    <name>Q1DFI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550452.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0308"/>
    <dbReference type="EnsemblBacteria" id="ABF91401">
        <property type="protein sequence ID" value="ABF91401"/>
        <property type="gene ID" value="MXAN_0308"/>
    </dbReference>
    <dbReference type="GeneID" id="41357807"/>
    <dbReference type="KEGG" id="mxa:MXAN_0308"/>
    <dbReference type="HOGENOM" id="CLU_976004_0_0_7"/>
    <dbReference type="OMA" id="ESAPPWV"/>
    <dbReference type="OrthoDB" id="821745at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="285" mass="31616" checksum="802F1C23299C4B42" modified="2006-07-11" version="1">MAEGEPGRSPMSTFTDELEANARARFVRWDSALWRELTGGAAQRLGQALFEAGTPAAQGEELLRAYLQLGAEAIGLGYLYPTSAGRQNFFTLAWSDLIPRLLAAVPSAERSQVFAQLWNLGENLESAPPWVQRIFWRVGRELTSLQDIEARLRETSSVALEPPDAPLAARAQAHWVDLSKEDSRFLPGPIHFLSPTVVCVHDRHRQAVAGRDAATQGIWLAETPVRLGAMGCREVPEQTHVESPHLDEALREDPRADAWFATLSNDWRVVATLHTSQHVLVFVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL4</accession>
    <name>Q1DFL4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mercuric reductase, truncated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550423.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0278"/>
    <dbReference type="EnsemblBacteria" id="ABF92860">
        <property type="protein sequence ID" value="ABF92860"/>
        <property type="gene ID" value="MXAN_0278"/>
    </dbReference>
    <dbReference type="GeneID" id="41357778"/>
    <dbReference type="KEGG" id="mxa:MXAN_0278"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_3_7"/>
    <dbReference type="OMA" id="WGAHAAT"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="348"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="463" mass="49111" checksum="662EBAEA72F03871" modified="2006-07-11" version="1">MAEAFDVVVIGAGPAGEVAGARAAEAGLSVALVEHELLGGECSYWACIPSKALLRPSEARWLAEHAAGVREKLQEGIDARAVLAHRDSMVNNYQDDSQVKWAENAKLKVVRGTGKLTGPRKVRVEDKDGAVRELEARKAVVLATGSHPRIPDIPGLKDAQPWDNRQGTAARQVPKRLVVLGGGAVGVELAQAWRSLGSEVTLVQRGKRLLSRAEPFAGEQVAQALRDAGARVLLGMNATRVQRPGGKGEVTVTLSNGEQVVADEILVAMGRVPRTEGIGLETVGLVGGKPVEVDDQLRAKGVDGGWLYACGDTNGRNLLTHMGKYQARMVGDVIAGKQARAWADAKATPQVVFTHPQVASVGLTEAKAREAGLPVRTVEQQLQDVSGTSLVGKGLTGTVKWVVDEKRRVLVGATFTGPEVGEMLHAATIAVAGEVPLDTLWHAVPSFPTMSEVWLKLLEAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT1</accession>
    <name>Q1DFT1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglycosylase SLT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550356.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0210"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91805">
        <property type="protein sequence ID" value="ABF91805"/>
        <property type="gene ID" value="MXAN_0210"/>
    </dbReference>
    <dbReference type="GeneID" id="41357712"/>
    <dbReference type="KEGG" id="mxa:MXAN_0210"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013746_1_0_7"/>
    <dbReference type="OMA" id="DEWVEHI"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188263" evidence="2">
        <location>
            <begin position="26"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="637"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="798" mass="87891" checksum="25A37C7F5DD519B1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT2</accession>
    <name>Q1DFT2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0209"/>
    <dbReference type="EnsemblBacteria" id="ABF88772">
        <property type="protein sequence ID" value="ABF88772"/>
        <property type="gene ID" value="MXAN_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0209"/>
    <dbReference type="HOGENOM" id="CLU_933271_0_0_7"/>
    <dbReference type="OMA" id="GDHCHCD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="SSF57184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="31522" checksum="1ACF1E388EFF3934" modified="2006-07-11" version="1">MGRVPHMTFRAPVIQRIQRAPRCDTGCSIPNGGARTHVGRPAARWRFAPPGPARAPAAANPAPRTLMQHGCATQLHVRYGQTCRSSLKASRHFTHVPGTVMHPRPLRLALLAATAILFAACGASDSDSDEIECGGYGHLHGDHCHCDEGYVADGLTCVIAEEPVEECGGHGHLHGDHCHCDEGYVADGLTCVIAEEPVEECGGHGHLHGDHCHCDEGYTEQDGTCVVAQEPTLDCGEHGHAHGDHCHCDAGYVEQNGTCVAETPVLDCGEHGHAHGDHCHCDAGYVEQNGTCAPAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFT6</accession>
    <name>Q1DFT6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="4">2.4.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lgt</name>
        <name evidence="4" type="ORF">MXAN_0205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550351.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0205"/>
    <dbReference type="EnsemblBacteria" id="ABF88766">
        <property type="protein sequence ID" value="ABF88766"/>
        <property type="gene ID" value="MXAN_0205"/>
    </dbReference>
    <dbReference type="GeneID" id="41357708"/>
    <dbReference type="KEGG" id="mxa:MXAN_0205"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_7"/>
    <dbReference type="OMA" id="YVDARYF"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="30126" checksum="0018368AAA684561" modified="2006-07-11" version="1">MGRSHPLEPPDVIPYWHAPSIELGPLKIEPFGILVAVGILLAARLLGRNAEREGLNPEPLADFAPWGVGVGVVVGHWVHLFFYHPEELSKSPFQILKVWDGLSSFGGLLGGILAAVVFFKVRKLRFSDYADSFALGVAPGWAVARLGCFAVHDHPGVPTDFFLAVAFPGGPRHDLGMYDAMALFAISGVLYALRNAGKLKGRLLPLLAVLYAACRFFFDFLRATDMAYVDARYFGLTPAQYGCIALALYGIWGVLRPQAPGAASSPPPSSPKSPGTVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG49</accession>
    <name>Q1DG49_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, HAE1 family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0091"/>
    <dbReference type="EnsemblBacteria" id="ABF92664">
        <property type="protein sequence ID" value="ABF92664"/>
        <property type="gene ID" value="MXAN_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0091"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_7"/>
    <dbReference type="OMA" id="NELFPGM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="60"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="378" mass="39946" checksum="C949F2F5D7F0A200" modified="2006-07-11" version="1">MPIQRSKRLLLASTLLPLLACDGKQEEAAFAPPVQKVSTLKVQGEAVVLHDEFPARVSAFRVAEVRPQVGGLVRSRRFSEGDTVQKGQPLYQLEAAVFRANVEGAAAAHAASEAGRLQAELHAGRIQSLFEKGASTQQAHDDARAALAIANAEVARARAALDRARVDLDYATITAPIAGHIGISQVNEGALVGPADATPLSVIQQIDRVFVDIKSPVERAAGLQSLQGGTGEAGAEVIVLSSTGAPYPERGRVQFSDISVDPGSGELTVRALVPNAQRKLLPGMFVKARVVLGEVAGALLVPQQAVLHDAQGQAQVFIVREDNTAEARNVRAGRIVSGRYLVEEGLSAGERVVVEGQDRLAPGQQVTPVEWQHAPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW6</accession>
    <name>Q1CVW6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7349"/>
    <dbReference type="EnsemblBacteria" id="ABF89194">
        <property type="protein sequence ID" value="ABF89194"/>
        <property type="gene ID" value="MXAN_7349"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7349"/>
    <dbReference type="HOGENOM" id="CLU_1458971_0_0_7"/>
    <dbReference type="OMA" id="ARPDWSR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="24630" checksum="B4E7A01A21D6F4BA" modified="2006-07-11" version="1">MAPPVSESPPVETLDLWLLEAAMELPTPLHMLVEPNPHIALNMADDPRLSREELCERLSLLAERGLIRVHALPDGLQELFSPEEISSAIDARQSRTPFGYSLTDAGGAIWEHHARPDWSRFVNAGQEPSADEAQDAWVIEAASLEAADAEFHFHESLGDVHQPVGESKHGEVLTPWQVTYWKTLPHGYRLRYVTVPRPADPARSRSVPSRPPWYTRVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ1</accession>
    <name>Q1CVZ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557238.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7319"/>
    <dbReference type="EnsemblBacteria" id="ABF87877">
        <property type="protein sequence ID" value="ABF87877"/>
        <property type="gene ID" value="MXAN_7319"/>
    </dbReference>
    <dbReference type="GeneID" id="41364482"/>
    <dbReference type="KEGG" id="mxa:MXAN_7319"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_4_2_7"/>
    <dbReference type="OMA" id="KWEKSTI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14603" checksum="7031BA96543949EA" modified="2006-07-11" version="1">MTRKPEPEVAPRPLTPVELELMHIVWRLGEVSVADVLAALPPERALAYTSVSTVLRILEQKGVVHSRKQGRGHLYSAVLPRDAYEAQSVRHLVETVFDGAPSALVARLVEAVPLSASDVDQLRKLLDAKGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW65</accession>
    <name>Q1CW65_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EH_Signature domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="MXAN_7245"/>
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    </dbReference>
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            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="467" mass="53499" checksum="1CCFA9225C8A8061" modified="2006-07-11" version="1">MGLDAWLTGVQERQRTALAGLGTFQQQVESGLRQLRVSLDEAQRRTDEREPGRALRVLESLDVEGVLGKVRVGDFSELSRRERRAVPWLWRRVEPASMEGFLSHFPESWPRLVRQRLRDWCLADGDSKRMREWSQLTSRYSTDSRLLRWNLPVSIEMALSPEGPKGVAARWGDRPLREVVDLMGHAGLRPAVGYSGHVVAEYLLQRCAARQDASESLLYLLEAEAGRAWLPSASADRSVIGAPLEARVAVIAAILECRAHGRVHKDAQSRVEERLIAKDSVFGDPRISILTEAWSAVRGRSKQAFEAFLSALIQQDLEFFFEKAMHERDRHVFWLRYLGSIRSTTCWLAPDAYDALLREVRTLPSEQQAAFRRAKRFSRYDVSAFCLRFDEYSVVEFSKTGNATYVYRNRDIDKVLRQENVECADDLKVRSLAEARLYHQPGWEPRFEQELLARGIEKAPAAKKRPF</sequence>
</entry>
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    <accession>Q1CWH0</accession>
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        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 15</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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    </reference>
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        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
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        <location>
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            <end position="828"/>
        </location>
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        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="857" mass="91940" checksum="7D2211C93C3DFDB6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI1</accession>
    <name>Q1CWI1_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">MXAN_7129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029074">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="28649" checksum="CD1DEC442E326F8D" modified="2006-07-11" version="1">MASKFLPVFIGNALGDNEELLPAFAAGKGGLKEALRFCQNFRVAGIGSLLLSGTSARLHECLHASARAFVFFSRASEETKKLTSRAAPFFDAVACGDDESARELSRFSPASPDKDREYEEDFLFVRFLMDHFFLERTAQDGQVLLSRYEKCLEGTTDARLLVCQALLAADGDAFDAALTQMMEEREVRYRRLAEKETEAEEVLATEAYVSIEGLALVRLAVRAGLKPQEDYLFIPSTALELPRLRYRADSWKHLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWK5</accession>
    <name>Q1CWK5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">MXAN_7105</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DK1622</strain>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_7105"/>
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    <dbReference type="OMA" id="MTMKERM"/>
    <dbReference type="OrthoDB" id="903607at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011478">
        <property type="entry name" value="DUF1585"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013036">
        <property type="entry name" value="DUF1587"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013039">
        <property type="entry name" value="DUF1588"/>
    </dbReference>
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        <property type="entry name" value="DUF1592"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013043">
        <property type="entry name" value="DUF1595"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07627">
        <property type="entry name" value="PSCyt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07624">
        <property type="entry name" value="PSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07626">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07637">
        <property type="entry name" value="PSD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="68"/>
            <end position="130"/>
        </location>
    </feature>
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        <location>
            <begin position="148"/>
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        </location>
    </feature>
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    </feature>
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        <location>
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            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="562" mass="61576" checksum="1188278CDFF9180B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWL4</accession>
    <name>Q1CWL4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557015.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7096"/>
    <dbReference type="EnsemblBacteria" id="ABF91086">
        <property type="protein sequence ID" value="ABF91086"/>
        <property type="gene ID" value="MXAN_7096"/>
    </dbReference>
    <dbReference type="GeneID" id="41364271"/>
    <dbReference type="KEGG" id="mxa:MXAN_7096"/>
    <dbReference type="HOGENOM" id="CLU_182100_0_0_7"/>
    <dbReference type="OMA" id="HEPKSHR"/>
    <dbReference type="OrthoDB" id="1976159at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="118" mass="12617" checksum="1F40123A02C7A73E" modified="2006-07-11" version="1">MEGDGKAVAPSLPHPQGGNMAVRTIVAGIKNRRRVGAHGAQPSVQASKGRKTMPHDDAAALRRQKTLERVTLGPAAEAHEPKSHRRRATPLKGRKKAPSEMNVKHLGGPKKRLPLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWV4</accession>
    <name>Q1CWV4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92471">
        <property type="protein sequence ID" value="ABF92471"/>
        <property type="gene ID" value="MXAN_7006"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7006"/>
    <dbReference type="HOGENOM" id="CLU_3120177_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="50" mass="5489" checksum="80C8DBF876D9FC2C" modified="2006-07-11" version="1">MLPEFPARDSAKPYALRLPEDVSLPLRPLPGALSHAVRLHLLRAAELTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWX0</accession>
    <name>Q1CWX0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6989"/>
    <dbReference type="EnsemblBacteria" id="ABF92716">
        <property type="protein sequence ID" value="ABF92716"/>
        <property type="gene ID" value="MXAN_6989"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6989"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210830_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="56" mass="6219" checksum="31CDE6AAD99E0D62" modified="2006-07-11" version="1">MVTDPACIVADRCLQLLGGYGYMKEYSFAHLFADTRVLRILAGANEIMKELVARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWZ0</accession>
    <name>Q1CWZ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556889.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6968"/>
    <dbReference type="EnsemblBacteria" id="ABF92914">
        <property type="protein sequence ID" value="ABF92914"/>
        <property type="gene ID" value="MXAN_6968"/>
    </dbReference>
    <dbReference type="GeneID" id="41364146"/>
    <dbReference type="KEGG" id="mxa:MXAN_6968"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="SMQARSE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13920" checksum="AFE1767CCBFFDB9F" modified="2006-07-11" version="1">MQPLQTLLVVDDDLDIRDALQDVFELEGYAVLLAADGLEALTQLRQVESMPDLILLDLMMPRMDGFAFHEALRHDTSFDRIPVLVASAGLDVKGAAEGLGVAGWLRKPLDLRELLNAVKRLSQLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX94</accession>
    <name>Q1CX94_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MotA/TolQ/ExbB proton channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_6862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556787.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CX94"/>
    <dbReference type="DIP" id="DIP-60614N"/>
    <dbReference type="IntAct" id="Q1CX94">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6862"/>
    <dbReference type="EnsemblBacteria" id="ABF90777">
        <property type="protein sequence ID" value="ABF90777"/>
        <property type="gene ID" value="MXAN_6862"/>
    </dbReference>
    <dbReference type="GeneID" id="41364051"/>
    <dbReference type="KEGG" id="mxa:MXAN_6862"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_4_3_7"/>
    <dbReference type="OMA" id="TSLEMPM"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="8">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="25938" checksum="2C674FC40C61246E" modified="2006-07-11" version="1">MDLASVTNLTVLANVGGPQRGFFEEIAMRWEAGQWGMYPIAACLIVALAIMVERSIILFGKASINKEAFLRGLKKHIYAGDLDKAINYVAGQKSTPLTNVIKAGLMNVPKGNDEVQAALDEASLRETPKIEARTGYLAMLGNAAMLAGLLGTVSGLIACFEAVANVNPADKAAILAIGISEAMNCTGFGLLTAIPALISFSVLTGRTQSLINDINETSVSVLNLIVANKDKFKNLNVPTAARDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXD2</accession>
    <name>Q1CXD2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556749.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6824"/>
    <dbReference type="EnsemblBacteria" id="ABF87583">
        <property type="protein sequence ID" value="ABF87583"/>
        <property type="gene ID" value="MXAN_6824"/>
    </dbReference>
    <dbReference type="GeneID" id="41364013"/>
    <dbReference type="KEGG" id="mxa:MXAN_6824"/>
    <dbReference type="HOGENOM" id="CLU_663614_0_0_7"/>
    <dbReference type="OMA" id="VYERPID"/>
    <dbReference type="OrthoDB" id="2012490at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187722" evidence="2">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="430" mass="45931" checksum="87FCD9B94EEA020C" modified="2006-07-11" version="1">MDSSMWRFALLLCLTSACAGPSVTTVRPEQPVPVPPPAAKVPPPPTPTGPFARELAPLPRQRVSSAEGIFTAEVEATSAPRLTRHEGSTRLEIPLGTEAALSCFVYERPIDAAGAVLAVAKAAQGHKGVTVRSMAPTEVTVVADAPVMFVDVDYEVVASGDSVSAGRLKLMVSASPELPLLCAHDEPGYARTFHRVTTGLAATLKVPGPARTPARTKALRVLKLDGRLAGFDWRTEQRLEGGSRRTEVSTSLLLPGATNGPHAEDRTITTVTDEEGRLKEQRHAHAEDGRLTLQVTLRREREPQPPTRAAPETAYRYEGRQGSRALKGTFTSKRGLATEDTVHDTVRDVLRPGGPAEAVLDVYRPADVPSAPTELVLRRVPSAGPRALTLTTGDATEEARAAESGTLEWTKRALPEGQLTSELIHGSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXD9</accession>
    <name>Q1CXD9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6817"/>
    <dbReference type="EnsemblBacteria" id="ABF90649">
        <property type="protein sequence ID" value="ABF90649"/>
        <property type="gene ID" value="MXAN_6817"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6817"/>
    <dbReference type="eggNOG" id="COG1873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1804110_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="143" mass="16075" checksum="3DA34192A1827E21" modified="2006-07-11" version="1">MHAARNRDAGLGVSSFPKPPLFPRRGPDCVRRNVHQWSNGRHLAWAAEHPGRVHLSRKEGVMWDPGELREGMAVRDEHGRRLGTVVHIGDTHFELEQGWPPSRDFMVSFHLVARVDHGEVFLHPGHGATVPTEDEMPDSGAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXE4</accession>
    <name>Q1CXE4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6812"/>
    <dbReference type="EnsemblBacteria" id="ABF91724">
        <property type="protein sequence ID" value="ABF91724"/>
        <property type="gene ID" value="MXAN_6812"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6812"/>
    <dbReference type="HOGENOM" id="CLU_2465809_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="88" mass="9379" checksum="22CA0C5FC02DBC17" modified="2006-07-11" version="1">MVMTGPSDKGERLWPWVGAALGVRWFLAAGGSPTLPLFQRLGDRVTCGVVDGFTVCVPTRDSDFREALKRAPPALFSQPLPASAGPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYF2</accession>
    <name>Q1CYF2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6447"/>
    <dbReference type="EnsemblBacteria" id="ABF87229">
        <property type="protein sequence ID" value="ABF87229"/>
        <property type="gene ID" value="MXAN_6447"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6447"/>
    <dbReference type="HOGENOM" id="CLU_1968165_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011750">
        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="13794" checksum="9CDE7DCF1B872D9F" modified="2006-07-11" version="1">MTLRVFELSQDSAMWPRINGSFNAAHKWGLPGLAGCPGCGVTWASSGHQYPAVDLSNLPAQFEFLKARPEPFEEFVRLRELVRPLAPPGALLPPGTLFGPLVGTASGRFADFETQGSMLLVVRREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYK2</accession>
    <name>Q1CYK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative (3R)-hydroxymyristoyl-(Acyl-carrier-protein) dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6397"/>
    <dbReference type="EnsemblBacteria" id="ABF85890">
        <property type="protein sequence ID" value="ABF85890"/>
        <property type="gene ID" value="MXAN_6397"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6397"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1625311_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="17923" checksum="3D0C1553E8AB3262" modified="2006-07-11" version="1">MRAAPWPWCCAGVLMTEHPMARIYGGTPHRFPMLLVDTVETLSPGFGRTFKQVSGNEMMFERFGDAPPALPSCLLVDALGQVAIMLLREPDEVTPSVWYLGGIETMTFHTPIPAGSVLRMEANILKRWRTTVRVEVKAWADAVPAASGVMVLSQRGSKSHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYP4</accession>
    <name>Q1CYP4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556287.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6355"/>
    <dbReference type="EnsemblBacteria" id="ABF90907">
        <property type="protein sequence ID" value="ABF90907"/>
        <property type="gene ID" value="MXAN_6355"/>
    </dbReference>
    <dbReference type="GeneID" id="41363568"/>
    <dbReference type="KEGG" id="mxa:MXAN_6355"/>
    <dbReference type="HOGENOM" id="CLU_288008_0_0_7"/>
    <dbReference type="OMA" id="WRRVEVF"/>
    <dbReference type="OrthoDB" id="36307at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1073" mass="120063" checksum="B1054630F01AEBEA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC1</accession>
    <name>Q1CZC1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556066.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6117"/>
    <dbReference type="EnsemblBacteria" id="ABF87020">
        <property type="protein sequence ID" value="ABF87020"/>
        <property type="gene ID" value="MXAN_6117"/>
    </dbReference>
    <dbReference type="GeneID" id="41363352"/>
    <dbReference type="KEGG" id="mxa:MXAN_6117"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561081_0_0_7"/>
    <dbReference type="OMA" id="QMAVWET"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="347"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="565" mass="62000" checksum="E639EA96CEBA5121" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZN4</accession>
    <name>Q1CZN4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555953.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6004"/>
    <dbReference type="EnsemblBacteria" id="ABF88465">
        <property type="protein sequence ID" value="ABF88465"/>
        <property type="gene ID" value="MXAN_6004"/>
    </dbReference>
    <dbReference type="GeneID" id="41363243"/>
    <dbReference type="KEGG" id="mxa:MXAN_6004"/>
    <dbReference type="eggNOG" id="COG5459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703417_0_0_7"/>
    <dbReference type="OMA" id="DWCHFVQ"/>
    <dbReference type="OrthoDB" id="1345405at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="406" mass="43887" checksum="7B806B1BE097D5D3" modified="2006-07-11" version="1">MSNAYSKDLERWMPRLIAVWRASRGRGGGGGPETRLTPQEVKEVAAGVRQLSLGLTRERQLAGARYMDDPKLLGAYLLFYWPVSYAQARQVLGELPNRPRQVLDLGSGPGPVAFAALDAGGGQVTAADRSKAALTLARNLAAEAGEALATRDWDPTKKGATLPDGQFDLITMGHVVNELYGTGDAATAPRAALLETILAKVKRGGSLLVMEPALRETSRGLLHVRDAMVAKGYAVRAPCMYRGPCPALVKETDWCHAERAWPMPRVVEELARAASLHKESLKMSYLVLAPKDEAWPELTPGRLFRIVSEPLEGKGRHRYIGCGPEGRVGLAMQERHRNERNERFLKLNRGDVISVTETEPKGDGLALDERTEVRVVAPAGKGVPPPPPEEDAPSSPGTGPRPGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR5</accession>
    <name>Q1CZR5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555922.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5973"/>
    <dbReference type="EnsemblBacteria" id="ABF86274">
        <property type="protein sequence ID" value="ABF86274"/>
        <property type="gene ID" value="MXAN_5973"/>
    </dbReference>
    <dbReference type="GeneID" id="41363212"/>
    <dbReference type="KEGG" id="mxa:MXAN_5973"/>
    <dbReference type="eggNOG" id="ENOG5030SZ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2753674_0_0_7"/>
    <dbReference type="OMA" id="EYRCATE"/>
    <dbReference type="OrthoDB" id="2030041at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="70" mass="7931" checksum="5EBBD8BE6251C094" modified="2006-07-11" version="1">MLFPAAGRNRHMSQQANVTKENDVWVLRIEKDNGKQQEYRCATENQARQLAMILSRPDTGGPPRQPAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW1</accession>
    <name>Q1CZW1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">folK</name>
        <name evidence="14" type="ORF">MXAN_5925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555876.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5925"/>
    <dbReference type="EnsemblBacteria" id="ABF90976">
        <property type="protein sequence ID" value="ABF90976"/>
        <property type="gene ID" value="MXAN_5925"/>
    </dbReference>
    <dbReference type="GeneID" id="41363163"/>
    <dbReference type="KEGG" id="mxa:MXAN_5925"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097916_0_1_7"/>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="13">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF90976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="19354" checksum="67D60190309FBF39" modified="2006-07-11" version="1">MSDTVYVGLGSNEGERENHLVAALSALSRIDAVAVLHCSSLFDSAPVGPPQPRFLNAVVALECGLPPQRLLCILQQIEKDLGRTREVRWGPRTIDLDILFWEGQVVADPTLQVPHLELHKRRFALEPLVELAPHLRHPVLGMSVKELLGKLAPQDVRRSEATWWPEASYSSNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D066</accession>
    <name>Q1D066_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase, M48 (Ste24 endopeptidase) family, AgmM</fullName>
            <ecNumber evidence="12">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">agmM</name>
        <name evidence="12" type="ORF">MXAN_5820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91278">
        <property type="protein sequence ID" value="ABF91278"/>
        <property type="gene ID" value="MXAN_5820"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5820"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_1_7"/>
    <dbReference type="OMA" id="LPFKIYK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="157"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF91278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="360" mass="40120" checksum="B1162882B499FAA9" modified="2006-07-11" version="1">MLGVLVQPLHRLAVAAAAGLERRLGFLRTAPVSRAFFHAMDRLWGKPGWGAAVLFALFTDLFVSLVYLPVDVWFSYTLEHRHGMSTQTPATFAYDMVKAQLLAAFALSALVIGMFGLARKLRQWWLVLGVPVALLLLVSGALDPYRSRLFFNQKALPEGPLRTRIVDLMEQADITFADVLVEETSVASRRLQAYFAGQGPTRTIVLNDIILKELSEDEVLAAVAHEAGHVNESKWPARIASSLMLVALLFALDRLLRLSASRGWFGATHFADIRNLPLISLLFFLLVLTAKPISGAFSREREREADRYALRLTNDVDAFRRMLVKAARVNKMDPEPPRWVVLKGMSHPPIGERIASLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D073</accession>
    <name>Q1D073_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Znf/thioredoxin_put domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555764.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5813"/>
    <dbReference type="EnsemblBacteria" id="ABF87569">
        <property type="protein sequence ID" value="ABF87569"/>
        <property type="gene ID" value="MXAN_5813"/>
    </dbReference>
    <dbReference type="GeneID" id="41364768"/>
    <dbReference type="KEGG" id="mxa:MXAN_5813"/>
    <dbReference type="HOGENOM" id="CLU_398340_0_0_7"/>
    <dbReference type="OMA" id="CTKCQNT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="787" mass="78727" checksum="29EB0EBFC54506CC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D084</accession>
    <name>SYA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="1">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alaS</name>
        <name type="ordered locus">MXAN_5802</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555753.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D084"/>
    <dbReference type="SMR" id="Q1D084"/>
    <dbReference type="STRING" id="246197.MXAN_5802"/>
    <dbReference type="EnsemblBacteria" id="ABF92148">
        <property type="protein sequence ID" value="ABF92148"/>
        <property type="gene ID" value="MXAN_5802"/>
    </dbReference>
    <dbReference type="GeneID" id="41363043"/>
    <dbReference type="KEGG" id="mxa:MXAN_5802"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_7"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000347692" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <sequence length="898" mass="98244" checksum="355E583C7352B75E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D095</accession>
    <name>Q1D095_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="347" mass="37753" checksum="0232E2FCCC9FE2E8" modified="2006-07-11" version="1">MADGERKRTLEVARRAPLAGELSGRTVLLVDDDPVHLRHVRDGLAPHGYVFTEAHDGAQALSAIRESRPDLILMDVEMPGLGGVEVCRIIKANAGEDGFGFIPVILMTARQAAGKVEGLELGADDYLVKPFDMLELSARVKSMLRLKALQDALVEKNRELDRANKELAARREELLALTRTDALTGLSNRRAFEERLNDEFARSRRYGAPLSLVMLDIDHFKRINDSFGHPFGDHVLKAVAQTARARLREVDLLARYGGEEFIALLPETGPADALRVCERVRDAIAALELEHVGGSGKPQCVRLTASLGVATVPSGDLPSAEALLRAADASLYAAKGAGRNRVHQHAA</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
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                <person name="Shvartsbeyn A."/>
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                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF93063.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
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    <sequence length="608" mass="64784" checksum="06FE50DD305413CE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0I1</accession>
    <name>Q1D0I1_MYXXD</name>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
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        <name evidence="8" type="ORF">MXAN_5704</name>
    </gene>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Kaiser D."/>
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                <person name="Eisen J.A."/>
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                <person name="Hinkle G."/>
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                <person name="Sullivan S.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90458.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="488" mass="52649" checksum="13E2AD55F29001A1" modified="2006-07-11" version="1">MEPARATPARPSASARQAAGLASHEGSRENPRLVTSPPPVSGPLEETMSRAMDAQRRSVVGAGAAVRLVGAALFLAISTTLWLAGGRDWGVYPPALGLYASVAGVLFMLRQRRVARGLGAVQSLVDVGLVYWIQSTTLLVSPFPAGVAGFSLGLFALVVALSGLGMRGTVVYGTALLSAVAQAALMRQASVGWGAVAIAVVALVLVAVVSHYGTGRLRNLAVTLSRLEVDRALEARRFQEVEEARRTIERMLADAQAQNAELQRLQRDKEQLTEFLVHDLRSPLSALTLSLSWMEQEVPQQGILGESVRTGLAVTARLDRMISDLMDVPRLEEGRLEPQRATFPATRIVEDVRRSLESVARARKLTLDAEVPVQLELEGDADLLVRVLENLTTNALRYAPSGGRVRLEAGADVNGRWLAVRNDGPPISEEARGRIFDKYEQADAERDSRRGYGLGLYFCRLAAEAHGGRLAVEDAPGWSTSFVLRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0W4</accession>
    <name>Q1D0W4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555524.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5570"/>
    <dbReference type="EnsemblBacteria" id="ABF87006">
        <property type="protein sequence ID" value="ABF87006"/>
        <property type="gene ID" value="MXAN_5570"/>
    </dbReference>
    <dbReference type="GeneID" id="41362817"/>
    <dbReference type="KEGG" id="mxa:MXAN_5570"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028255_0_0_7"/>
    <dbReference type="OMA" id="YTAVHEK"/>
    <dbReference type="OrthoDB" id="1292731at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="37678" checksum="7996954B3B26DA86" modified="2006-07-11" version="1">MISPRWLVAPQEFKGTLSAAEAAEAMARGLRESSPEVVLDVAPLADGGPGTVEALLTGLRGERRQQVVRGPLGAPVEAHWALVEDGRTAVVEMASASGLSLLAPEARDALKASTYGTGELMHAALESGCERLIVCLGGSATTDAGTGALSALGFRFLDARGQPLPPGGAALAQLARVGASGRHPRLGAVELLGATDVTSPLLGPDGAARLFGPQKGADEAGVEALEAALAHAATVLGDTSAGWPGAGAAGGFGFGLLALAGARLVPGYELVSRALGLERRVLMADVVLTGEGRFDRQTALGKGPGGIARLAREHGTPVVLFAGQVQRDEGLALDLFHEVVELSANAQPGEAASKVLCEAAARWAAQRLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Z0</accession>
    <name>Q1D0Z0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbD_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555498.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5544"/>
    <dbReference type="EnsemblBacteria" id="ABF92829">
        <property type="protein sequence ID" value="ABF92829"/>
        <property type="gene ID" value="MXAN_5544"/>
    </dbReference>
    <dbReference type="GeneID" id="41362792"/>
    <dbReference type="KEGG" id="mxa:MXAN_5544"/>
    <dbReference type="eggNOG" id="COG2836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032635_1_0_7"/>
    <dbReference type="OMA" id="GRISTYM"/>
    <dbReference type="OrthoDB" id="1654599at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="237" mass="23916" checksum="873F49E96BE8C902" modified="2006-07-11" version="1">MSPEPAALASLLHTSEPTVIAGALGAFVVGLTGSVHCLLMCGPLACAGLPGVPGPERRRAVVAYQGARLGAYALVGGALGMLGGGVTQALAVSTRPYLPWLMAVALVASALELGKRLRPLPGMANLARHVTRWGAKFSWTGRASAMGAVTPLLPCGLLYGVFAVALASGSFGGGALVLAAFALGGLPALLGAQLQAALWKHRPKWMSLLLQRAVPLVAAAVLVYRAVSVNAGGASCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H3</accession>
    <name>Q1D1H3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recN</name>
        <name evidence="9" type="ORF">MXAN_5350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555315.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5350"/>
    <dbReference type="EnsemblBacteria" id="ABF88071">
        <property type="protein sequence ID" value="ABF88071"/>
        <property type="gene ID" value="MXAN_5350"/>
    </dbReference>
    <dbReference type="GeneID" id="41362619"/>
    <dbReference type="KEGG" id="mxa:MXAN_5350"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_7"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="317"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="578" mass="62080" checksum="926111FCCE5B9F10" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1J9</accession>
    <name>Q1D1J9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555289.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87878">
        <property type="protein sequence ID" value="ABF87878"/>
        <property type="gene ID" value="MXAN_5324"/>
    </dbReference>
    <dbReference type="GeneID" id="41362593"/>
    <dbReference type="KEGG" id="mxa:MXAN_5324"/>
    <dbReference type="HOGENOM" id="CLU_153019_0_0_7"/>
    <dbReference type="OMA" id="AQFGLRK"/>
    <dbReference type="OrthoDB" id="1915565at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="13847" checksum="69960DE674256A9F" modified="2006-07-11" version="1">MLYKVTPMMAPPAPEKAKQREPGQGQPRKRRKSAVYDADGQEVLISLMCIKCKTLKPLAQFGLRKMADGAIRNQPWCRTCRSGAGSKKPKAGKDAAAVAPVEEAAPVLQVVPAAASPEAGESPAVPVAAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V0</accession>
    <name>Q1D1V0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5221"/>
    <dbReference type="EnsemblBacteria" id="ABF92183">
        <property type="protein sequence ID" value="ABF92183"/>
        <property type="gene ID" value="MXAN_5221"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5221"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141675_1_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13356" checksum="DDF141CD99E3E558" modified="2006-07-11" version="1">MTQPIHPVGGATFDLAAVEREMRREDAYQREGHTARTLVREPDLRIVLIVMKAGARMAEHRASETVSVHALSGHVRLRLPDKTVELPFGRLLVLEKGLRHDVEAIEESAFLLTLGWKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X1</accession>
    <name>Q1D1X1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5199"/>
    <dbReference type="EnsemblBacteria" id="ABF92836">
        <property type="protein sequence ID" value="ABF92836"/>
        <property type="gene ID" value="MXAN_5199"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5199"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064267_0_0_7"/>
    <dbReference type="OMA" id="DKYLYRA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="51"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="170"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="33917" checksum="D2452476B3846B86" modified="2006-07-11" version="1">MGAAMSEEKTSVHSISDLLGSAQQQSAYLIVISAKSAAGIGRMFKLDRSEVVLGRSSEAQFQVEDDGISRKHAKVVALGDGRFQLVDLASTNGTYLNGLKVNAAPLYDGDKIQIGSNTVLKFSIQDALEEQYQRSIYESATRDGLTRVYNKKYFLETVRKEFSYCLRHRVPLSLVLFDVDHFKKINDAYGHPAGDYVLTRIAQRVSDTVRTEDLLARYGGEEFALMLRESAEDQALACAERCRYAVDKADFVFSGTPIKVTISLGVATLLDSDFSQPEDLIAAADKYLYRAKRAGRNRVDAKAISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D227</accession>
    <name>Q1D227_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division coordinator CpoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ygbF</name>
        <name evidence="1" type="synonym">cpoB</name>
        <name evidence="3" type="ORF">MXAN_5143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CpoB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555114.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5143"/>
    <dbReference type="EnsemblBacteria" id="ABF87682">
        <property type="protein sequence ID" value="ABF87682"/>
        <property type="gene ID" value="MXAN_5143"/>
    </dbReference>
    <dbReference type="GeneID" id="41362425"/>
    <dbReference type="KEGG" id="mxa:MXAN_5143"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044315_3_0_7"/>
    <dbReference type="OMA" id="YWLGEVN"/>
    <dbReference type="OrthoDB" id="1099900at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="35735" checksum="1F97B61BD3300472" modified="2006-07-11" version="1">MLPSGWSFPSRSGDRPAGQALAGAPTGREKSGRAGRLRLRWRPMRSLALISLLALPGCFYPADRGRALEAKVDRLGTDSAQIQAELKETREQLVATLPKIDEKVAEVTKALKGLDTAARRKDADIGVQFQKTVEDLAQLRGQVETYLHKITELETALAAQDQKLVAMQGEAALKEAEAKKKAEELKRPTDKKEFLALAKAKAKAGDVLLARQLYNEFMKKWAKDPLVGDAHFGLGETYFSESKCREALFEYGKVLQDFPKAESAPESYLRSSDCFAQLKMKEESRLALEELIKSYPKSAEAKTAKERIAELDKKAAPAKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2A0</accession>
    <name>Q1D2A0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">apqZ</name>
        <name evidence="8" type="ORF">MXAN_5069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555044.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5069"/>
    <dbReference type="EnsemblBacteria" id="ABF91985">
        <property type="protein sequence ID" value="ABF91985"/>
        <property type="gene ID" value="MXAN_5069"/>
    </dbReference>
    <dbReference type="GeneID" id="41362353"/>
    <dbReference type="KEGG" id="mxa:MXAN_5069"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_2_7"/>
    <dbReference type="OMA" id="IFKALMY"/>
    <dbReference type="OrthoDB" id="1744995at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="28131" checksum="6BBE781D0C8AF661" modified="2006-07-11" version="1">MDASRDRAALARAGNPRNNDAVRKYVAEFIGTFVLVLGGVGAAVLAGDHIGFQGVALAFGLSLLAMVYVIGPISGCHVNPAVTLGLLLSGKMEGKDAVGYVVAQCAGAILGAGVVLLIAKGMPGGYSAVTEGLATNGYGAASPDGFNMGAAFLTEVALTFLLVLTVLGATDARAPVGFAGLAIGLVLALIHLVGIPVTNTSVNPARSLGPAVFAGSVPMGQLWLFIVAPLLGGATAAAVYRTVFRPAVPISAEEAERALRREREARIAEDRAGTRAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2A4</accession>
    <name>Q1D2A4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555040.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5065"/>
    <dbReference type="EnsemblBacteria" id="ABF87678">
        <property type="protein sequence ID" value="ABF87678"/>
        <property type="gene ID" value="MXAN_5065"/>
    </dbReference>
    <dbReference type="GeneID" id="41362349"/>
    <dbReference type="KEGG" id="mxa:MXAN_5065"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643769_0_0_7"/>
    <dbReference type="OMA" id="VIEEHFS"/>
    <dbReference type="OrthoDB" id="1684783at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011959">
        <property type="entry name" value="CHP02270"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02270">
        <property type="entry name" value="TIGR02270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="46749" checksum="11AD46E79746EE19" modified="2006-07-11" version="1">MPTLRIDVIEEHFSEAAFLYSQWERALRGANYNLEETAQLEERLLAHLDGLVLGGEPVAEALLSPALDGGEPGEVFCSVFASIAESPPAALEVVLALAPVAPPEVLASLRRALELSGRTGLDASLVPLLKAPEASVQALALEVLSFRGAVPRGVALKLLDQADGRVVAAALRGLGTLERDVGHRELRRLLDDNRPQVRLAAIESGLLSGVRAAWDACRQEAQGCGEGAPPARLLQAICGDDEDVERLVALMANDVVRADIVWALGFTGRVAAVEACLELMGHVPSVARLAGESFSAITGLVLKDTYAVELEEGDSLPPLEEDDLEADLSSKEEDNLPVPARAAVADWWQRARQDYSRSGRYLGGKPFSGAALLDVLARGPMRRRHVHARDLALRTQGIHDVQTRAFTARQGAELAEAQRVREHLSTRPLKRAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D303</accession>
    <name>Q1D303_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2017" name="EMBO Rep." volume="18" first="1090" last="1099">
            <title>&lt;i&gt;In vivo&lt;/i&gt; structures of an intact type VI secretion system revealed by electron cryotomography.</title>
            <authorList>
                <person name="Chang Y.W."/>
                <person name="Rettberg L.A."/>
                <person name="Ortega D.R."/>
                <person name="Jensen G.J."/>
            </authorList>
            <dbReference type="PubMed" id="28487352"/>
            <dbReference type="DOI" id="10.15252/embr.201744072"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (24.00 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554795.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="5URW">
        <property type="method" value="EM"/>
        <property type="resolution" value="24.00 A"/>
        <property type="chains" value="11/12/13/14/15/16/21/22/23/24/25/26/31/32/33/34/35/36=1-163"/>
    </dbReference>
    <dbReference type="PDBsum" id="5URW"/>
    <dbReference type="SMR" id="Q1D303"/>
    <dbReference type="STRING" id="246197.MXAN_4809"/>
    <dbReference type="EnsemblBacteria" id="ABF91911">
        <property type="protein sequence ID" value="ABF91911"/>
        <property type="gene ID" value="MXAN_4809"/>
    </dbReference>
    <dbReference type="GeneID" id="41362108"/>
    <dbReference type="KEGG" id="mxa:MXAN_4809"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116190_1_0_7"/>
    <dbReference type="OMA" id="RINHAGM"/>
    <dbReference type="OrthoDB" id="1153621at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03344">
        <property type="entry name" value="VI_effect_Hcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="5URW"/>
        </source>
    </evidence>
    <sequence length="163" mass="18045" checksum="C7E3224CE001242B" modified="2006-07-11" version="1">MAESVHLYLKANGSDIKGDSTQTSLGRADSIECVAYSQKVFTAREAGSGLATGRRQYEGIEITKRIDKSSPLLMKALCENQVIDATFKFFRPNPTGDGTTEQFYTVSIKKARINAIQQTVPNSFVPASTNLPPMETLQLVFHTINWTITQGGVTHEDTWDTQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D339</accession>
    <name>PLSX_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">MXAN_4772</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554759.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D339"/>
    <dbReference type="SMR" id="Q1D339"/>
    <dbReference type="STRING" id="246197.MXAN_4772"/>
    <dbReference type="EnsemblBacteria" id="ABF87405">
        <property type="protein sequence ID" value="ABF87405"/>
        <property type="gene ID" value="MXAN_4772"/>
    </dbReference>
    <dbReference type="GeneID" id="41362071"/>
    <dbReference type="KEGG" id="mxa:MXAN_4772"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_7"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329241" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <sequence length="353" mass="36631" checksum="7B342F04CE5ECDBF" modified="2006-07-11" version="1">MRLVLDAMGGDHAPAAPVEGGVLFARAHPGHEVLLVGDEAKVAPLLGKLRPPSNLQVHHASEVVEMDEHASTAFRRKRDSSLRVGFELVRDGRAEALVSAGNSGAVMAGGLLTLGRLPGVERPAIAALFPALKGGGRCLLLDAGANVDCKPTHLAQFAVMGEAYVRARMGVARPRVAVLSNGEESSKGTPLTREASGLLRRSDLDFVGYVEGKDLFSGEVQVVVTDGFTGNVVLKTSEGVGMGVIGMLRQAIERRGGLAEKVGAMLLQPALAGLRRVVDYAEYGGAPLLGIQGVGIVAHGRSTPRALFNALGAALAMAEGGVQAELTRCIGRAAAWLPTHPKGKRATDAGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3P9</accession>
    <name>Q1D3P9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554551.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4556"/>
    <dbReference type="EnsemblBacteria" id="ABF90934">
        <property type="protein sequence ID" value="ABF90934"/>
        <property type="gene ID" value="MXAN_4556"/>
    </dbReference>
    <dbReference type="GeneID" id="41361857"/>
    <dbReference type="KEGG" id="mxa:MXAN_4556"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011068_0_0_7"/>
    <dbReference type="OMA" id="NETMGFF"/>
    <dbReference type="OrthoDB" id="1406236at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="120"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="584"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="775" mass="83875" checksum="E2D5D31CD463500B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3U6</accession>
    <name>Q1D3U6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554504.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4508"/>
    <dbReference type="EnsemblBacteria" id="ABF86942">
        <property type="protein sequence ID" value="ABF86942"/>
        <property type="gene ID" value="MXAN_4508"/>
    </dbReference>
    <dbReference type="GeneID" id="41361815"/>
    <dbReference type="KEGG" id="mxa:MXAN_4508"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_248414_0_0_7"/>
    <dbReference type="OMA" id="VRMEWAS"/>
    <dbReference type="OrthoDB" id="17924at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1506" mass="167077" checksum="4818C0CB37169BE2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z6</accession>
    <name>Q1D3Z6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554454.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4456"/>
    <dbReference type="EnsemblBacteria" id="ABF87411">
        <property type="protein sequence ID" value="ABF87411"/>
        <property type="gene ID" value="MXAN_4456"/>
    </dbReference>
    <dbReference type="GeneID" id="41361767"/>
    <dbReference type="KEGG" id="mxa:MXAN_4456"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_3_2_7"/>
    <dbReference type="OMA" id="YHASYLR"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="142" mass="15854" checksum="B4DE42DC46E523DD" modified="2006-07-11" version="1">MVEARLRVIYGDTDQMGVVYYANYFRYFEFARSEYFRARGGSYAELERSGALLPVAEASCQYKASARYDDLLVIQTTVSELRRASIVFTYALFRDGAPRTLLCTGMTRHACVGRDGKPTRLPDSLIRLLETTGPSPGSSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D486</accession>
    <name>Q1D486_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554365.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4364"/>
    <dbReference type="EnsemblBacteria" id="ABF87823">
        <property type="protein sequence ID" value="ABF87823"/>
        <property type="gene ID" value="MXAN_4364"/>
    </dbReference>
    <dbReference type="GeneID" id="41361675"/>
    <dbReference type="KEGG" id="mxa:MXAN_4364"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007267_0_0_7"/>
    <dbReference type="OMA" id="IRYRVAM"/>
    <dbReference type="OrthoDB" id="1107867at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="1">
        <location>
            <begin position="53"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="29691" checksum="99AF1EAF3B1B69AB" modified="2006-07-11" version="1">MPRSRSLFAALTFGLGAFHGGCIAYNDSCQPLVEDPDAVVGYLADDVLLDKVYTRHDNNALGQLVADALLHAEDDSTRPAVLGVVNGGSLRQEGLCVTRTELRQGPLTDGVLHELILFENLVVTVDLTEKELVDMLELSVGALYLEGQSIASPSGAFLHVSEGSSLRVDCGQPKGSRVRELTVGGVPVTLPAREDASIRYRVAMNAYILEGGDGYGTALGNAGQNPDRNPVQARKLGGTEANLASAYMKAKHPTPVQALREESRVVFQNCALPARPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B7</accession>
    <name>Q1D4B7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r1_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4332"/>
    <dbReference type="EnsemblBacteria" id="ABF89834">
        <property type="protein sequence ID" value="ABF89834"/>
        <property type="gene ID" value="MXAN_4332"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4332"/>
    <dbReference type="HOGENOM" id="CLU_2586026_0_0_7"/>
    <dbReference type="OMA" id="GFMAESP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r1_1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="96" mass="10586" checksum="FAF267C0F16310C0" modified="2006-07-11" version="1">MTGGRNYLWRKGGVAVENRIGKSYIARKALFAKGLKEGRLTVQEIEEALPAGTLTAAERWLLYYSLRAAQVEIIDEVTGQVDHGFMAEAPAAPQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B8</accession>
    <name>Q1D4B8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ORF">MXAN_4331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554333.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4331"/>
    <dbReference type="EnsemblBacteria" id="ABF90701">
        <property type="protein sequence ID" value="ABF90701"/>
        <property type="gene ID" value="MXAN_4331"/>
    </dbReference>
    <dbReference type="GeneID" id="41361643"/>
    <dbReference type="KEGG" id="mxa:MXAN_4331"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_7"/>
    <dbReference type="OMA" id="LEGPFKA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="209" mass="23012" checksum="2283A234D640B26E" modified="2006-07-11" version="1">MAGNTRTDAAPEAPQQPPSANGEGPVSAAEEASSQQQAPEEHAAAGQDAERERMVAELETLRKKFDIAVRAVQAAEKDREEFKQRVTRERERMLDVERGNVAVTLLEAIDELDRCLSVSAQDTSPLAEGVRMIRDELLRKAQSTGIERLQVVGQTFDPNTADAVDMEVTATPDDDHRIVAELRAGYRLKDRVIRPARVKVAKYVAPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4P4</accession>
    <name>Q1D4P4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554207.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4204"/>
    <dbReference type="EnsemblBacteria" id="ABF91868">
        <property type="protein sequence ID" value="ABF91868"/>
        <property type="gene ID" value="MXAN_4204"/>
    </dbReference>
    <dbReference type="GeneID" id="41361521"/>
    <dbReference type="KEGG" id="mxa:MXAN_4204"/>
    <dbReference type="eggNOG" id="ENOG502Z87C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052983_0_0_7"/>
    <dbReference type="OMA" id="ASREYAY"/>
    <dbReference type="OrthoDB" id="1783453at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025178">
        <property type="entry name" value="DUF4105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13387">
        <property type="entry name" value="DUF4105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187877" evidence="2">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4105" evidence="3">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="435" mass="47597" checksum="24AC36838F294C9A" modified="2006-07-11" version="1">MARHAVLILVVALFRAAAFAAPPPEGFGGHPESLRIRLVTIGPGADMHQRFGHSALWVEDTRLKKGLLYSYGTTSIANGGPVRFLLGRPTFWAARLSVERTFLLYRALARSIDVQDLMLTVEQRQRLLARLERDVQPASREYAYHPLKDNCATRVRDVLDEALGGALREALTEPARATQRELLRRYIQTHPVSELLLMLWLNDAVDAPATQWEEAFLPRELARLLMGVSYVDGSGRRIPLVNREGASSPSMDASAPVDAGWEGTSAWGLGAGGAALAIILAFLRGRGTHRMFQILFGLYHAVFGLTLGAAGVALGGLMLFSRLDVMQGNENLLLANPLAFGLLPLGILMMSGSERAERWARRCVWLLAAGSLLAVVLKLLPSFDQDNRRPMALWLVANLGLGLAHAWRLRRPSTAPAPAAGAREGARGSTRWWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q4</accession>
    <name>Q1D4Q4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554197.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90098">
        <property type="protein sequence ID" value="ABF90098"/>
        <property type="gene ID" value="MXAN_4194"/>
    </dbReference>
    <dbReference type="GeneID" id="41361511"/>
    <dbReference type="KEGG" id="mxa:MXAN_4194"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1702354_0_0_7"/>
    <dbReference type="OMA" id="NDRRTAW"/>
    <dbReference type="OrthoDB" id="1408715at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19513" checksum="902511EFBB47A02E" modified="2006-07-11" version="1">MSQFVDLKLRGNDRRTAWCQESSVGTDLYRDGMARLDAGDVGEARRLLEEALRKSPGDVAVMHGLSRVLDLAGERVRSVELLEHAHARAPSEPGPAHDLAMALLEREEDVRAVQVLTPVLEAHPEDTRAHLFMAMALAKSDAARARVHTAKALSDSDPDVKLQAQALDDVLAEHQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Z3</accession>
    <name>Q1D4Z3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4102"/>
    <dbReference type="EnsemblBacteria" id="ABF88739">
        <property type="protein sequence ID" value="ABF88739"/>
        <property type="gene ID" value="MXAN_4102"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4102"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="SFYKKDC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="32896" checksum="E05F96282F615D94" modified="2006-07-11" version="1">MTNQEPAIEVRGLRKTYHRAFRKGGTEALRGMDLTVPEGSAFGLIGPNGAGKTTFIKSILGIVQPTEGSIRVLGGSPEDPRIRARIGYLPERLHLPGTWTAPAFLATVTRLKGLPVDPAVNLRLLERVGLSDAVGRRIGGYSKGMRQRLGLAAALVGTPSLLVLDEPTDGIDPMGRMEVRRILQDEVQRGTTLFLNSHLLAETERVCDRVAILAGGRVVREGRLEDLARGGVRWLVRFAPGANAEALVTAGFVRGVAEGQYVVEAEDPAALNRALDRARAAGALMVELRRDGTDLESVLMGTVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D506</accession>
    <name>Q1D506_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carotenogenesis protein CarR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carR</name>
        <name evidence="2" type="ORF">MXAN_4089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554096.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4089"/>
    <dbReference type="EnsemblBacteria" id="ABF88965">
        <property type="protein sequence ID" value="ABF88965"/>
        <property type="gene ID" value="MXAN_4089"/>
    </dbReference>
    <dbReference type="GeneID" id="41361418"/>
    <dbReference type="KEGG" id="mxa:MXAN_4089"/>
    <dbReference type="HOGENOM" id="CLU_1244218_0_0_7"/>
    <dbReference type="OMA" id="CAWGALS"/>
    <dbReference type="OrthoDB" id="1869584at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="22995" checksum="6DB2ED5A43DA2EB0" modified="2006-07-11" version="1">MKPPMDLDSLLTQTPAKDNAALERVLAAARGELALRRPVRRWRTQAVGLMAASAGLGLLAAVVLLAVGAVTGPLLLARAPLLAMLVGTSAVCAWGALSPKGRWMRRLGVGLAVVSAAALVLARGAPHSPPSFPGWVCTVSHLAIGVVPLVVALFALRGAFFQPLRAVVAGLSVGSTGALLGELACEQDWRHVLSHHLLAWVVITVVLVVISKSLKPRSYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D580</accession>
    <name>Q1D580_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">prt1</name>
        <name evidence="10" type="ORF">MXAN_4013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554023.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4013"/>
    <dbReference type="MEROPS" id="M04.025"/>
    <dbReference type="EnsemblBacteria" id="ABF92285">
        <property type="protein sequence ID" value="ABF92285"/>
        <property type="gene ID" value="MXAN_4013"/>
    </dbReference>
    <dbReference type="GeneID" id="41361345"/>
    <dbReference type="KEGG" id="mxa:MXAN_4013"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008590_0_1_7"/>
    <dbReference type="OMA" id="FCTIVPP"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="77"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="189"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="384" mass="42791" checksum="42B4846AA78B144A" modified="2006-07-11" version="1">MFHPTRHRHSIHCILPPYLARSIAENGTSEQRERVLRTLSTDSTFRALRLAGSRTTPSTLVTRPRAMMVESALHRTIYDLRNSEAFPGTPVRFEGQEATDDIAVTEAYDGLGDTYNFFWEIFGRSSIDGDGMPLQAFVHYGNTYDNAFWDGRRMVFGDGDGDLFNRFTICLDIIAHELAHGVTEDEGPLWYFRQAGALNESMSDVFGSLVRQMKLKQKADAADWLIGKELLTGNVEGVALRSMKNPGTAFDDDVLGKDPQPGHMKDYVHTWEDNGGGHINSGIPNRAFYLVASHLGGYAWERAGRIWYDAIRDSHIKPDMGFLDFARITVMSATRLFGAGEEEDAVREAWEQVGIRVARSGVRMPAFVGAVTQPSPQAGRAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D582</accession>
    <name>Q1D582_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554021.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4011"/>
    <dbReference type="EnsemblBacteria" id="ABF91501">
        <property type="protein sequence ID" value="ABF91501"/>
        <property type="gene ID" value="MXAN_4011"/>
    </dbReference>
    <dbReference type="GeneID" id="41361343"/>
    <dbReference type="KEGG" id="mxa:MXAN_4011"/>
    <dbReference type="HOGENOM" id="CLU_1244225_0_0_7"/>
    <dbReference type="OMA" id="EDFEREP"/>
    <dbReference type="OrthoDB" id="1629955at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="24413" checksum="F7AD18D76DB842B7" modified="2006-07-11" version="1">MRHRAWSKTAIGRRARAGILPAMRMNRSLVFCLLLTACATTPREPASVAEAYARALEEGRVGDAFALTVGGPEEEAAFLERYSDAGARSARAADVRAGAPLLEARAPSLTVAQSTQGWRVVEARPADVPRAALRQFIDSVEARDWTAAWGQLAGPLRARYTPERLREDFEREPLAKERLRRARLALNTHVRVGAGEAVFPLGDERAVRLVLEEGEYRIAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D661</accession>
    <name>Q1D661_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553693.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3675"/>
    <dbReference type="EnsemblBacteria" id="ABF92180">
        <property type="protein sequence ID" value="ABF92180"/>
        <property type="gene ID" value="MXAN_3675"/>
    </dbReference>
    <dbReference type="GeneID" id="41361010"/>
    <dbReference type="KEGG" id="mxa:MXAN_3675"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_0_7"/>
    <dbReference type="OMA" id="ACKREPP"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188311" evidence="4">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="169" mass="18554" checksum="461DFA6161D746D6" modified="2006-07-11" version="1">MRTPTALSLLLLGLSPLTWACKREPPPAYVRLQGTAPTVADVPPSRALLIVFWASWCPPCRQETPQLVALAQAPPEDLQVVVFSHDETPQAVESFFKGPPPTPLHLRLDVDKRAGDAFGADQLPVSVLLVDGRQVARFSGPREWDAGAMRRLLERLIREPSPSAPRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6C7</accession>
    <name>Q1D6C7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85888">
        <property type="protein sequence ID" value="ABF85888"/>
        <property type="gene ID" value="MXAN_3608"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3608"/>
    <dbReference type="HOGENOM" id="CLU_2396593_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="93" mass="10324" checksum="47BEAF1E0B94CE29" modified="2006-07-11" version="1">MRADFWRRAAECATPSSPARPSRTPGRAPRKALQVSLVGLLTFQDARSPGLHRLALLSSTFRRHPALPLAAELSNFSPSMTRNPRFLVTINTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6J6</accession>
    <name>Q1D6J6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding monooxygenase, PheA/TfdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553563.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3533"/>
    <dbReference type="EnsemblBacteria" id="ABF92159">
        <property type="protein sequence ID" value="ABF92159"/>
        <property type="gene ID" value="MXAN_3533"/>
    </dbReference>
    <dbReference type="GeneID" id="41360878"/>
    <dbReference type="KEGG" id="mxa:MXAN_3533"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_2_7"/>
    <dbReference type="OMA" id="RRVYTHH"/>
    <dbReference type="OrthoDB" id="867226at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="541" mass="59425" checksum="9C206021AFFE9C12" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L2</accession>
    <name>Q1D6L2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553547.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87550">
        <property type="protein sequence ID" value="ABF87550"/>
        <property type="gene ID" value="MXAN_3517"/>
    </dbReference>
    <dbReference type="GeneID" id="41360861"/>
    <dbReference type="KEGG" id="mxa:MXAN_3517"/>
    <dbReference type="HOGENOM" id="CLU_1990242_0_0_7"/>
    <dbReference type="OrthoDB" id="1881585at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="14531" checksum="A88B5D16528BE447" modified="2006-07-11" version="1">MLCMPRPTMSIDFTCQKCEASFELDAQDLIEGTEKIVCPHCDAKAPANLTEDFVAALTEMRAQIAALDKRFAVSMTLESEDLEDMLDDDDEEDDEDESEDDDLDEDEDEDVDDEEDYDEDEDDDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6N9</accession>
    <name>Q1D6N9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553520.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88050">
        <property type="protein sequence ID" value="ABF88050"/>
        <property type="gene ID" value="MXAN_3489"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3489"/>
    <dbReference type="HOGENOM" id="CLU_2423865_0_0_7"/>
    <dbReference type="OrthoDB" id="2160400at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="9265" checksum="C3306EFFE86CD09D" modified="2006-07-11" version="1">MLSLVVGVAVGCGVGAMDSEGAQDEALATSEASLAICGDGVCEIGERLSCPLDCPRGEFCGNGACCPGETARTCPEDCTQGDPGRYCYRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P5</accession>
    <name>Q1D6P5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553514.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3483"/>
    <dbReference type="EnsemblBacteria" id="ABF88154">
        <property type="protein sequence ID" value="ABF88154"/>
        <property type="gene ID" value="MXAN_3483"/>
    </dbReference>
    <dbReference type="GeneID" id="41360830"/>
    <dbReference type="KEGG" id="mxa:MXAN_3483"/>
    <dbReference type="eggNOG" id="ENOG50344HH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756099_0_0_7"/>
    <dbReference type="OMA" id="LEREYTH"/>
    <dbReference type="OrthoDB" id="734550at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="366" mass="40672" checksum="06A004974A5F47B7" modified="2006-07-11" version="1">MNQRVANRVNSIAVSAYKFIGSLLLALIMLGLVSFLSVQGFFLVSRSWVTPTVISPTDPQILTLNTQVAAQTSARDHVLSDRRSVENRISDAERTVAAERAFQQRFLVALRGERDARDRVARRLALLRREYSSARAEILQSNRAFAGLARTRTDALYDARMMEQEEKLTINHHLAQLAQSNLALAQSSADLETRLDSLQREIAGLSAVQSGMGKNETPQGMTSDVLLLEREYTHSVLEQARAEATLKSLQTDLAALDEVALRYDTLIASLRASPYLKAIERDLTVAFVPYENIPNAEQGTPLYSCAAKVLWCHEVGVIGRVLEGEVSLKHPIRQYMLRGVMVEVQLTDAPSAREDLLHLGRPPLLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D756</accession>
    <name>RL15_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">MXAN_3318</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553354.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D756"/>
    <dbReference type="SMR" id="Q1D756"/>
    <dbReference type="STRING" id="246197.MXAN_3318"/>
    <dbReference type="EnsemblBacteria" id="ABF87720">
        <property type="protein sequence ID" value="ABF87720"/>
        <property type="gene ID" value="MXAN_3318"/>
    </dbReference>
    <dbReference type="GeneID" id="41360671"/>
    <dbReference type="KEGG" id="mxa:MXAN_3318"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_7"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251530" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="175" mass="18701" checksum="3AACD8D9C731CCB1" modified="2006-07-11" version="1">MSTLNKLQRPARSWHRKKRVGRGQGSGLGKTAGRGGKGQKARTGNMRFEGFEGGQSPLQRRLPKFGFTPPNRTVYAVVNLSDLEQHFDAGATADVETLRKVGLVKGRYHGVKLLARGELTKKVTVVVHKASEAAKAAIQKAGGAVEEIPLVAHKPESAAKAHAGKGVKAPRQPKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D777</accession>
    <name>EFG2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 2</fullName>
            <shortName evidence="1">EF-G 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA2</name>
        <name type="ordered locus">MXAN_3297</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553341.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D777"/>
    <dbReference type="SMR" id="Q1D777"/>
    <dbReference type="STRING" id="246197.MXAN_3297"/>
    <dbReference type="EnsemblBacteria" id="ABF86551">
        <property type="protein sequence ID" value="ABF86551"/>
        <property type="gene ID" value="MXAN_3297"/>
    </dbReference>
    <dbReference type="GeneID" id="41360650"/>
    <dbReference type="KEGG" id="mxa:MXAN_3297"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_7"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263474" description="Elongation factor G 2">
        <location>
            <begin position="1"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="8"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="691" mass="76612" checksum="69B6B5C96EAA333B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D792</accession>
    <name>Q1D792_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3282"/>
    <dbReference type="EnsemblBacteria" id="ABF87460">
        <property type="protein sequence ID" value="ABF87460"/>
        <property type="gene ID" value="MXAN_3282"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3282"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_7"/>
    <dbReference type="OMA" id="DCFCHTG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="403" mass="44167" checksum="564EF6A74EC00B2C" modified="2006-07-11" version="1">MRSDTVNVVKLELARGLGRHLRAGHPWVFRKALEHVPKIPAGSVVDLTENGKFVARGYYDPHSAIAVRVLTRDSRDTVDAGFITRRVRQALSERTALIDLTDTDSYRLIHGEGDGLPGVVVDLYAGWAVMKLYSAGLTPYRPLLIEALKAGVPGLKGIIGRDEVGRDDVDEDEGRGSGKMLFGHEAPELIPIRERGATFLVDAWKGQKTGFFLDQRENRYLIRRLGKGRDVLNCFSFSGGFSVNAALGGANSVFSVDQDPDAIALARENFTRNGIAAEKHDFLAADVFKIIQSFKDEGRTFDLIILDPPAFAKSQRAVQAAIDGYASLNRQALAILRPGGLLATASCSARVSPDDFMGAVREAGFKAGVDLALVEERYQPPDHPVRLQFPEGKYLKFYVLQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E0</accession>
    <name>Q1D7E0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553279.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3234"/>
    <dbReference type="EnsemblBacteria" id="ABF89204">
        <property type="protein sequence ID" value="ABF89204"/>
        <property type="gene ID" value="MXAN_3234"/>
    </dbReference>
    <dbReference type="GeneID" id="41360588"/>
    <dbReference type="KEGG" id="mxa:MXAN_3234"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863082_0_0_7"/>
    <dbReference type="OMA" id="TWPDAQE"/>
    <dbReference type="OrthoDB" id="938511at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="34635" checksum="6549A41E153E5BD7" modified="2006-07-11" version="1">MQPQTTNWLPGIIVLAVTFVLAAGWILFQRRKGSLASAEPRDGVLDDLTQRAQSLIDQLRALEAEKHNQSAEQYAAEKSRLEREAAAALRAKDEHLKRKASGEGVRARPQAPAPTGWASRNPQLVGALWGAGIMVFFGGLGYLLVSEQQTRTDGMEATGRMPPGGAAAQQQGAGMDDQMQEGPEMQEARARLNANAGDVDAAALLSHELIRRQQFDEAVKVTAKGLAADPFNVELKVHRGVLRATQGDMAGAEAELTELVDTWPDAQEALIFLGSLALRRGDKAAALAHFERFSVEVPRNMQPPQLGPAIAQLRAEVAGGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L2</accession>
    <name>Q1D7L2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553207.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3158"/>
    <dbReference type="EnsemblBacteria" id="ABF86419">
        <property type="protein sequence ID" value="ABF86419"/>
        <property type="gene ID" value="MXAN_3158"/>
    </dbReference>
    <dbReference type="GeneID" id="41360517"/>
    <dbReference type="KEGG" id="mxa:MXAN_3158"/>
    <dbReference type="HOGENOM" id="CLU_777786_0_0_7"/>
    <dbReference type="OMA" id="RIWLAHE"/>
    <dbReference type="OrthoDB" id="755831at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="37617" checksum="48F4493D6DF662BD" modified="2006-07-11" version="1">MIWRTDVERCAGRREADMKPHMLTFFCELEAEPLRELFATPGVVEDLAALEAGVSLGLLDLGPERAQVVQRLNRMGIPVTAWLLLPTDEGYWFHAGNVAQATARYEAFQAWTAEHHLTWEGVGLDIEPDIRELRRWMEGGWRQLGEILPRLVQGHRVRDARAGYARLMERIRADGYRVDAYQFPIIVDERESRSTLVQRLAGVLDLPADREVLMLYTSFLRPHGPSVLWSYGPGSQSLAVGITGGGVELPGAFAAKPLDWTEFSRDLRLAVRWTHDLHVFSLEGCVQQGFLNRLRTFDWDAPVTPPATAARRVDTVRRAARLLLRTSAWVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7M6</accession>
    <name>Q1D7M6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative xanthine dehydrogenase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553194.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3144"/>
    <dbReference type="EnsemblBacteria" id="ABF89887">
        <property type="protein sequence ID" value="ABF89887"/>
        <property type="gene ID" value="MXAN_3144"/>
    </dbReference>
    <dbReference type="GeneID" id="41360503"/>
    <dbReference type="KEGG" id="mxa:MXAN_3144"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041115_4_1_7"/>
    <dbReference type="OMA" id="WIWGAGH"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014308">
        <property type="entry name" value="Xanthine_DH_XdhC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02964">
        <property type="entry name" value="xanthine_xdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="3">
        <location>
            <begin position="104"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="278" mass="30370" checksum="5B850A0813AE7DB3" modified="2006-07-11" version="1">MWDWTRQLAEWSRDDVPFAVATVTVCQGSTPAKPGAKLLVRADGTFHGTVGGGHLEQLVLADARACLEKGEPRAYRYPLGSKLGQCCGGVVDVFMEPVNHGPRLYLFGAGHVGQALCRTLDGTPFQVHLVDERPEWVHGERIPASVIRHEEPWDVFASRAVWDARRTYIAVMTHRHDLDQDIIAFALEKPARYVGLIGSNTKWARFRQRLEARGATAAQLARVRCPIGLEIGGKSPQEVAVSIAAGLLQLHHQGADTETTAEAPPSETPRMRGGSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7P7</accession>
    <name>Q1D7P7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553173.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3123"/>
    <dbReference type="EnsemblBacteria" id="ABF86080">
        <property type="protein sequence ID" value="ABF86080"/>
        <property type="gene ID" value="MXAN_3123"/>
    </dbReference>
    <dbReference type="GeneID" id="41360484"/>
    <dbReference type="KEGG" id="mxa:MXAN_3123"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841520_0_0_7"/>
    <dbReference type="OMA" id="YHEIRQF"/>
    <dbReference type="OrthoDB" id="649881at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="350" mass="38505" checksum="A66E4A80600FB8E7" modified="2006-07-11" version="1">MGRRGRRVGNSRRKALQWDAMAQFLDVALKVGDLTEFTADAVLFKYAQSLYGATGQAARRLEQAGVPLAQLELAPGATRLVETRGALTARRALFVGTVRLGEFGYHEIRQFAVRALAALENHSGLAHVAGTVHGPNYGLDEDEAVLAFVGGLVEAFQRGSGPQSLARFTVVERNASRAQRLAKAFARGLSATPGVETLPEGVFRVRRMSSVTQAPPLATAGTVSMAKPHAFVAMPFAPELEDTYHYGIQGPVKAARMLCERVDQELFDGPIIQRIRERIETAKVVIADLSLANPNVYLEVGYAWGRGRPTLLLVRDVKELRFDVASYRCIVYRNIRELEQSLTKELQRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Q0</accession>
    <name>Q1D7Q0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553170.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87217">
        <property type="protein sequence ID" value="ABF87217"/>
        <property type="gene ID" value="MXAN_3120"/>
    </dbReference>
    <dbReference type="GeneID" id="41360481"/>
    <dbReference type="KEGG" id="mxa:MXAN_3120"/>
    <dbReference type="eggNOG" id="ENOG5032K1T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160092_0_0_7"/>
    <dbReference type="OMA" id="FFVLWVK"/>
    <dbReference type="OrthoDB" id="1197163at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="239" mass="26430" checksum="0D36C1B80F7780B3" modified="2006-07-11" version="1">MTEPKPRPSENELPPVLGRVAFLAVVSGLTPLIPVPFLDDYALRQARESMVLTILSEHGLPRPAQAVEVLAGSHVGRTAGGRLMSYMKGLVLFPVRKVFRKIFFVLWVKDCVDVASSALHHGYLLNHAMDRGDLRPEDMEGPLPGKIHDAIVAACAELDPRPVNQALRRLFVGSRLLMAEATRAFFSSDALGPRTPEPGESAEVKTLTERLIAALWEERGYFAALQQHYDTHLKARHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7R6</accession>
    <name>Q1D7R6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553154.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D7R6"/>
    <dbReference type="STRING" id="246197.MXAN_3104"/>
    <dbReference type="TCDB" id="3.A.7.18.2">
        <property type="family name" value="the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87242">
        <property type="protein sequence ID" value="ABF87242"/>
        <property type="gene ID" value="MXAN_3104"/>
    </dbReference>
    <dbReference type="GeneID" id="41360465"/>
    <dbReference type="KEGG" id="mxa:MXAN_3104"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085040_0_0_7"/>
    <dbReference type="OMA" id="WFNKQRI"/>
    <dbReference type="OrthoDB" id="1382102at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="288" mass="31711" checksum="174D87877AB17F7E" modified="2006-07-11" version="1">MIDQNSRPARKVGIADHLWEAFEDMAQQMGSDRDALINQALFMFARLNGFLEVKSRSEAAVAPVAAAPVKPVQAAAAAPPRPAAPPVLAPAPRPESTPAPARPPVRATPEERAPANGLDNDPVRREVAERVLETAAELERLIKGKNSEPPPPADDMVEEDEEPLPEAEDPGLMDEEPPPDEAEEEPADDLAEEEEVGALYLVTESGDQEQIVKDRFVIGRGKHCDFVINSGKVSREHAVIVHEGDDWIIEDLGSSNGTWFNKQRIKRRKVEDGDEYFICSEKIRLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7V3</accession>
    <name>Q1D7V3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3062"/>
    <dbReference type="EnsemblBacteria" id="ABF86929">
        <property type="protein sequence ID" value="ABF86929"/>
        <property type="gene ID" value="MXAN_3062"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3062"/>
    <dbReference type="HOGENOM" id="CLU_1747666_0_0_7"/>
    <dbReference type="OMA" id="DFFICSD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188302" evidence="1">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="171" mass="18187" checksum="508E7B1881A84E2E" modified="2006-07-11" version="1">MKRKTAPAVSSVIRTHRFQETPMLRRQRLSSLAALLAAVTCSAPVLAADVDPASLYEVSTEGTSTQVKAGEKGTFVLAIKTKAGAHVSDEAPLKLEVKGSQLTPAKEKLVLADSVAKKAEGQAFADPRFEVPFTTAAAGKGSVDAKLVFFICTEKICARQQKTFSLPVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D886</accession>
    <name>Q1D886_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin, 2Fe-2S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552986.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2926"/>
    <dbReference type="EnsemblBacteria" id="ABF89375">
        <property type="protein sequence ID" value="ABF89375"/>
        <property type="gene ID" value="MXAN_2926"/>
    </dbReference>
    <dbReference type="GeneID" id="41360293"/>
    <dbReference type="KEGG" id="mxa:MXAN_2926"/>
    <dbReference type="eggNOG" id="COG3411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126515_1_1_7"/>
    <dbReference type="OMA" id="WYHSATP"/>
    <dbReference type="OrthoDB" id="1412344at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="113" mass="12302" checksum="69AE1AE424F63A27" modified="2006-07-11" version="1">MAPPYQRHVFVCTNRRPDGNPKGCCASKGAEEVRAAFKAELDKRGLKGGMRANAAGCLDTCSFGVAVVVYPEGTWYGGVKVEDVKDIVEQHLMEGRPVERLLMPFSRKTVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8N7</accession>
    <name>Q1D8N7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein, GvpL/GvpF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552836.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2769"/>
    <dbReference type="EnsemblBacteria" id="ABF87520">
        <property type="protein sequence ID" value="ABF87520"/>
        <property type="gene ID" value="MXAN_2769"/>
    </dbReference>
    <dbReference type="GeneID" id="41360146"/>
    <dbReference type="KEGG" id="mxa:MXAN_2769"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065736_3_0_7"/>
    <dbReference type="OMA" id="NGPWAPH"/>
    <dbReference type="OrthoDB" id="1869432at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="29864" checksum="46B706B8B31FF489" modified="2006-07-11" version="1">MPRAKTRHEKSTPEGRYLYAVVPIEVVDSLNLDTPGIQGADVHPVTSGKLAAIVSDIEQQTLRPERKHLSTHSAVLGQVMDQAPMLPVAFGIIAGSEREVRNLLAEHANDFLTQLRAVRGNVEMGLRIRLSDPDAFGYYVNAFPELKAMRDDLYREGEPSREEKIELGKYFVDLLNGFREATADKVLDGIESVARQTVVNEPRNESEVVNLAALVPQKKVDAFNATVEKLGATLPENFQVNVTGPWPPYNFTHLRIHFEEVEEAAQGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R2</accession>
    <name>Q1D8R2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CvpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552811.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2744"/>
    <dbReference type="EnsemblBacteria" id="ABF89078">
        <property type="protein sequence ID" value="ABF89078"/>
        <property type="gene ID" value="MXAN_2744"/>
    </dbReference>
    <dbReference type="GeneID" id="41360122"/>
    <dbReference type="KEGG" id="mxa:MXAN_2744"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110863_0_0_7"/>
    <dbReference type="OMA" id="LLFICTW"/>
    <dbReference type="OrthoDB" id="1033931at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="27038" checksum="6CDBBE53006C4B04" modified="2006-07-11" version="1">MVIDLIILGLVLFFAMIGAITGASRQVANVVGLAVGYFASRRLGPVAAPHLAEALGSPLFLGAIVGTVLLFICTWLAVRYALGALLLRILSTGQHNENRGVDRFLGFVLGGAKMGIIAWVVLSAIAFFEQHVVIAGRRVGLSPKESLSIEVARRYNLFEMTQFAPVKNLVEVAKAAGDPKRAGRLQDDPAYKALRKDPRFQRLLQDPKLKQALARGDTAALLRHDGVLQLIQDPDVAARLGAAARASEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D7</accession>
    <name>Q1D9D7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2517"/>
    <dbReference type="EnsemblBacteria" id="ABF89408">
        <property type="protein sequence ID" value="ABF89408"/>
        <property type="gene ID" value="MXAN_2517"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2517"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982908_0_0_7"/>
    <dbReference type="OMA" id="TEKAHNL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="31868" checksum="95AEC9FBF4630D01" modified="2006-07-11" version="1">MREDGGEVLGVYRDPLGGHPVVFSVLPIDKVEPTPYQRDVSEPHVKRLANAMERLDRFLDPVIAVRKDGRYWTPNGNHRLNASRRLGAKAIVALVLPEEDVAYQILALNTEKAHNLKERSLEVIRMYRGLVGAERKGPETAFAHLFEEPAFITLGAAYEQRPRFSAGAYHPFVKAVEDFLDTPLEDALPLREARARRLLELDDAVVSVVDALKERGLQSPYLKNFVVARINFLRFRKDGGKPDFDATVDRMQASARKFNVDKVRREDIGRMGGGPLEPDEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9F4</accession>
    <name>Q1D9F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552571.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2500"/>
    <dbReference type="EnsemblBacteria" id="ABF91209">
        <property type="protein sequence ID" value="ABF91209"/>
        <property type="gene ID" value="MXAN_2500"/>
    </dbReference>
    <dbReference type="GeneID" id="41359878"/>
    <dbReference type="KEGG" id="mxa:MXAN_2500"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_1_7"/>
    <dbReference type="OMA" id="WLHRVMV"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="19155" checksum="328BCC9024EE5D56" modified="2006-07-11" version="1">MHACALPPLSELYTEHRPRALAIARRIVGDTADAEDVVQDVFARLARRAPGYGGRAAWSTWLHRVMVNSSINWLRARKRRDRLSHDVQEPLSPEALAVGAEMERHFGEAMEDINEQQRQVLYLREVRGLSYPEIARLLRIPEGTVKSTLHRARQRTLSLMEERGQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK2</accession>
    <name>Q1DAK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552176.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2092"/>
    <dbReference type="EnsemblBacteria" id="ABF89598">
        <property type="protein sequence ID" value="ABF89598"/>
        <property type="gene ID" value="MXAN_2092"/>
    </dbReference>
    <dbReference type="GeneID" id="41359499"/>
    <dbReference type="KEGG" id="mxa:MXAN_2092"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_0_7"/>
    <dbReference type="OMA" id="DNAFTTD"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188581" evidence="3">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="61"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="204"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="454" mass="50660" checksum="5FD8BAE15E49E75F" modified="2006-07-11" version="1">MRRLLPLLLLLLGTALPAAAAAPTPASDAFPYTLHTDTLPNGLTVVRVPYPSRGIIAYVTVVRVGSRNEVEPGRTGFAHFFEHMMFKGTKTHPEGDRERILGNFGYDDNAFTTDDITLYYSYGPTAGLPQLIEIEADRFRNLEYSQPSFQTEALAVLGEYHKNAAAPFLKMEEELNAAAFTRHTYQHTTMGFYKDIQAMPQAYDYSRTFFERWYTPDNTLLFIIGDFDDAKVMELVRQHYGPWDRKAAQVSVPAEPPQKGPRTAHIDWPQPTQPRQVIAWRTPGAGTSPVDAAIQTLLVDYLAGPTSPAYKTLVLDKQLVESIGSDYSEHRDPHLFTLTATLKDERHRNTVRKTLLQEVSRLAAGRVDAARLKAIQDHARYGALMALETPRDVGIQLGWYAGVTGSPDGFQRHLQSLPKVTPAQLSDFAKRYLTANKLILLSLTPKTDAQGGTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAN8</accession>
    <name>PANC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate synthetase</fullName>
            <shortName evidence="1">PS</shortName>
            <ecNumber evidence="1">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panC</name>
        <name type="ordered locus">MXAN_2056</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552140.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAN8"/>
    <dbReference type="SMR" id="Q1DAN8"/>
    <dbReference type="STRING" id="246197.MXAN_2056"/>
    <dbReference type="EnsemblBacteria" id="ABF90225">
        <property type="protein sequence ID" value="ABF90225"/>
        <property type="gene ID" value="MXAN_2056"/>
    </dbReference>
    <dbReference type="GeneID" id="41359465"/>
    <dbReference type="KEGG" id="mxa:MXAN_2056"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_0_0_7"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000305494" description="Pantothenate synthetase">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>beta-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <sequence length="292" mass="31778" checksum="66D607FAC689ECEA" modified="2006-07-11" version="1">MAPAVLKTVADVKDWTAGLRREGHRLALVPTMGFLHEGHLSLIREGRRRADVVAVSIFVNPTQFGPKEDLSRYPRDFEGDVAKCISAGAQAIFAPAGPEVMYPQGYQTYVEVTDVSQGLCGARRPGHFRGVATVVTKLLTLFRPEVALFGEKDYQQLQVIRALNQDLHLGADIVGMPTVREPDGLAMSSRNAYLSPEERQRALALSRGLKAAQALLREGTRESEPLVAAVRRELEAAGLREDYVELVDAERLTPLASVAPGQPARLLVAAFSGTTRLIDNMQLGGEENAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ6</accession>
    <name>Q1DAZ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_1934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1934"/>
    <dbReference type="EnsemblBacteria" id="ABF89915">
        <property type="protein sequence ID" value="ABF89915"/>
        <property type="gene ID" value="MXAN_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1934"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526497_0_0_7"/>
    <dbReference type="OMA" id="YLEQAHR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039521">
        <property type="entry name" value="PIG-B/GPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="PTHR22760"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR22760:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="525" mass="56318" checksum="0F17F8A3FD5D9666" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB64</accession>
    <name>Q1DB64_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="57"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="172"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="221" mass="23683" checksum="D3315548CA007734" modified="2006-07-11" version="1">MTSTTQGPASVHRLVDMVVEEVSLVDRAANKHRFLLVKRDDMHDAPQDSAQAEDTSKAEDALLAAAQKALEAVTALVEALASTDGIDGVRVVEVAQHLRALADALEDEDEDEEDVEAREKTASSEPPPAQPAPPAPTPGADASGLQESLTKLTDAVRALEGSVKEQHQRLGRVEKQFGLPNSSAPAERPPKPTVEDVGWPLDLNKPLNRESVDKALSFHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG9</accession>
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        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
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        <name evidence="1" type="ORF">MXAN_1754</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="gene ID" value="MXAN_1754"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="25896" checksum="75C4A0845209B14F" modified="2006-07-11" version="1">MNPTYDFKGQVALVTGASSGMGLATAKAFAAAGASVVLADVNTAALTSAVDALTSAGHSALGVTCDVSDEAQVAALVRRAVEAYGRLDMAFNNAGIQAPPTDAADEPSDLFDRVNGINLRGVWACMKHELKQMRQQGSGAIVNCSSLGGLVGLPGRAAYHASKHGVIGLTRSAALEYAPRGIRINAICPGTISTPMVTDMLAKGELDLAGAIANQPIGRLGEAEEIAASVLWLCSPGASFVTGVALPVDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBN3</accession>
    <name>Q1DBN3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="17">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">MXAN_1688</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1688"/>
    <dbReference type="EnsemblBacteria" id="ABF87138">
        <property type="protein sequence ID" value="ABF87138"/>
        <property type="gene ID" value="MXAN_1688"/>
    </dbReference>
    <dbReference type="GeneID" id="41359126"/>
    <dbReference type="KEGG" id="mxa:MXAN_1688"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016091_0_0_7"/>
    <dbReference type="OMA" id="SVQKPGR"/>
    <dbReference type="OrthoDB" id="2074833at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0798">TonB box</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188110" evidence="13">
        <location>
            <begin position="34"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="15">
        <location>
            <begin position="80"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="16">
        <location>
            <begin position="219"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="14">
        <location>
            <begin position="596"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABF87138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="869" mass="93689" checksum="95B3104F0BFEBBFC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBQ5</accession>
    <name>Q1DBQ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551777.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1666"/>
    <dbReference type="EnsemblBacteria" id="ABF87803">
        <property type="protein sequence ID" value="ABF87803"/>
        <property type="gene ID" value="MXAN_1666"/>
    </dbReference>
    <dbReference type="GeneID" id="41359106"/>
    <dbReference type="KEGG" id="mxa:MXAN_1666"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086313_0_0_7"/>
    <dbReference type="OMA" id="PGIHPGV"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="281" mass="30333" checksum="830FB29746BDD6BE" modified="2006-07-11" version="1">MRPSTPDSTADDPLDDFTRRPLTLNDAMRTVYVAGHGPAVIVMAEMPGISPHVARFARWVRDAGFTVYMPSLFGRDGAYPRAEEGRAIMQRACVSAEFRAFAANESSPVTQWLRALARLAHEECGGPGVGAIGMCFTGNFALSMMLEPAMLAPVMCQPSLPLSDTGAIQLAPDELAAVKERLERDDLTVLAYRFEGDRFCTAQRFQAYTAALGKRFVPRVLPTSAANPTPPPFFAEVVGCAHSVVTAHLIDAEGEPTRAARDEILAFFAQRLGRAGAQSAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC88</accession>
    <name>Y1478_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein MXAN_1478</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_1478</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551594.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DC88"/>
    <dbReference type="SMR" id="Q1DC88"/>
    <dbReference type="STRING" id="246197.MXAN_1478"/>
    <dbReference type="EnsemblBacteria" id="ABF87109">
        <property type="protein sequence ID" value="ABF87109"/>
        <property type="gene ID" value="MXAN_1478"/>
    </dbReference>
    <dbReference type="GeneID" id="41358924"/>
    <dbReference type="KEGG" id="mxa:MXAN_1478"/>
    <dbReference type="eggNOG" id="COG1666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099839_1_0_7"/>
    <dbReference type="OMA" id="SDFDRQE"/>
    <dbReference type="OrthoDB" id="1612988at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000261952" description="UPF0234 protein MXAN_1478">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <sequence length="165" mass="18609" checksum="C248104AA52EBD18" modified="2006-07-11" version="1">MPSFDVVSKIDLAELDNAVNQTKKELSTRYDFQGTHADVVLAPDNTAITVKANSEDRVQAAKEVLLTKLAKRNISLFALEYGDIEKTGLHNVKQVIKLQQGIPVEKSKELVKLLKDSKMKVQGSIQADQLRVTGKNRDDLQAAIALFRKEQDRLKLDMQFINFRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCA2</accession>
    <name>GATB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatB</name>
        <name type="ordered locus">MXAN_1464</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551580.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCA2"/>
    <dbReference type="SMR" id="Q1DCA2"/>
    <dbReference type="STRING" id="246197.MXAN_1464"/>
    <dbReference type="EnsemblBacteria" id="ABF88634">
        <property type="protein sequence ID" value="ABF88634"/>
        <property type="gene ID" value="MXAN_1464"/>
    </dbReference>
    <dbReference type="GeneID" id="41358910"/>
    <dbReference type="KEGG" id="mxa:MXAN_1464"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_7"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000016006" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <sequence length="479" mass="52679" checksum="597E757A59FBEC74" modified="2006-07-11" version="1">MPVSDFQPVIGLEVHAQLLTQSKIFCGCSTAFGAEPNRNTCPVCLGMPGVLPVLNQRVAEFAVRTGLALECTIRPTSVWSRKNYFYPDLPKGYQITQFDQPICEHGRLVIDTPQGEKAIRILRIHMEEDAGKSVHDAGGGQSLVDLNRAGVPLLEIVSQPDLRDADEAVEYLKAMRDVLVYLGVNDGNLEEGSFRCDANVSVMPKGSTTFGQRCELKNLNSFRFLKQAIEYEIARQVDVIESGGKVVQETRLWDVNKGVTRSMRSKEEAHDYRYFPEPDLPPLHVSAEAIAAAAKALPELPRAKLQRFTSQYGLPAYDARILTAERPLADYFEACAGHYKDYKKLSNWFLGELMRLLKEEGTPLSALRFTPAQLGELLGAVDQGMVSANAGKDVLGEMFRTGKAPADIIAEKGLAQVSDTGAIEAVVDDILAKNAGEIEKYRAGKKQVFGFFVGQVMRAMKGKGNPALVNELLKKKLGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCG7</accession>
    <name>FMT_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">MXAN_1399</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551516.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCG7"/>
    <dbReference type="SMR" id="Q1DCG7"/>
    <dbReference type="STRING" id="246197.MXAN_1399"/>
    <dbReference type="EnsemblBacteria" id="ABF90944">
        <property type="protein sequence ID" value="ABF90944"/>
        <property type="gene ID" value="MXAN_1399"/>
    </dbReference>
    <dbReference type="GeneID" id="41358846"/>
    <dbReference type="KEGG" id="mxa:MXAN_1399"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_7"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000118484" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="312" mass="33075" checksum="1A537547637949A0" modified="2006-07-11" version="1">MSRPRIVFMGTPEFAVSSLAACFELGDVVAVVTQPDKPKGRGNTVTAPPVKELALSRGVPVLQPTKLRTPPFAEELRQYAPDVCVVTAYGRILPKDLLELPTHGCVNVHGSLLPRFRGAAPIQWAIAHGDTETGVSLMVMDEGLDTGPVLAMKRMAIAPDETSASLYPKLAALGGEVLREFLPAYLSGELKPVPQPSEGMVLAPIIEKDQGRLDFTKPAVELERRLRAFTPWPGAFTTLGGKLLKVHRAQARGGSGAPGTVLASGPDGIEVACGEGSLVLLDLQPEGKRVMRAADFLQGHKLAPGSQPFVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL1</accession>
    <name>Q1DCL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551472.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1355"/>
    <dbReference type="EnsemblBacteria" id="ABF89153">
        <property type="protein sequence ID" value="ABF89153"/>
        <property type="gene ID" value="MXAN_1355"/>
    </dbReference>
    <dbReference type="GeneID" id="41358801"/>
    <dbReference type="KEGG" id="mxa:MXAN_1355"/>
    <dbReference type="HOGENOM" id="CLU_1710159_0_0_7"/>
    <dbReference type="OMA" id="GLQKNEF"/>
    <dbReference type="OrthoDB" id="1708965at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="15777" checksum="0EB199C2A989F1B5" modified="2006-07-11" version="1">MSTPSLTPLLLAQADYAKPVSSLSPKYFELLEQNSHIIYPVLAILTLVIIAAGVLQAWRTQDLDGLQKNEFKRAIVNELRRNISGMPGDLLAKSVGLDRLKTNRLLEQMQQEGLVVSHTNSQRLTVWRVRGATPDAAPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCM1</accession>
    <name>Q1DCM1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_1345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551462.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1345"/>
    <dbReference type="EnsemblBacteria" id="ABF87263">
        <property type="protein sequence ID" value="ABF87263"/>
        <property type="gene ID" value="MXAN_1345"/>
    </dbReference>
    <dbReference type="GeneID" id="41358791"/>
    <dbReference type="KEGG" id="mxa:MXAN_1345"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_3_7"/>
    <dbReference type="OMA" id="IGCLERA"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="139"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF87263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="454" mass="50073" checksum="AD4ED24EDAF1E1B3" modified="2006-07-11" version="1">MPALPPAPIPSHTVIGARTQGERLSAQLFHLVLLDTERAGTVFPLANEALRVGKAPDNDVVIDHPTVSRNHLVVRRQGDRFLVQDLGSTNGTFLDGAQVREAFLRPGALLEVGDVRLRFSPQVSPVQVEPILEDRLGDLVGRSLPMRQIFALLQRIAPTDSTVLLVGETGSGKGAAAKATHKLSPRAGGPLVVFDCASVSDSLIESELFGHEKGAFTGAVSQRIGCLERANGGTLFLDEIDDLALDLQPKLLRAIEDREFRRLGASSPISFDARIIVASKKDLWAETQAGRFREDLYFRLSVFTVSLPSLRDRKEDIPLLVDAFAGEGLWPRLPEKIREQFTGHTWPGNVRELRNALERARHMVDIPELAGDTLLREFTREAPAAAGDSLPVEFTGPFKVCKDELIRAFEREYLTRLLGRAKGNIARAAREAELDRKHLYSLLHKYGLVQSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCY1</accession>
    <name>Q1DCY1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551352.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1233"/>
    <dbReference type="EnsemblBacteria" id="ABF91250">
        <property type="protein sequence ID" value="ABF91250"/>
        <property type="gene ID" value="MXAN_1233"/>
    </dbReference>
    <dbReference type="GeneID" id="41358682"/>
    <dbReference type="KEGG" id="mxa:MXAN_1233"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_0_0_7"/>
    <dbReference type="OMA" id="QDEYPIC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="65202" checksum="9A352D1973B7F0B1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP6</accession>
    <name>Q1DDP6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551087.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0966"/>
    <dbReference type="EnsemblBacteria" id="ABF88104">
        <property type="protein sequence ID" value="ABF88104"/>
        <property type="gene ID" value="MXAN_0966"/>
    </dbReference>
    <dbReference type="GeneID" id="41358424"/>
    <dbReference type="KEGG" id="mxa:MXAN_0966"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067080_0_0_7"/>
    <dbReference type="OMA" id="NYFQHRP"/>
    <dbReference type="OrthoDB" id="1230456at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188631" description="Lipoprotein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30265" checksum="C7AD23FBDC3A5448" modified="2006-07-11" version="1">MKSPSRSLLTPLLLSVTLLLTACQKQEASSGESSGVRTLKVGVNPVPHGDILRAAAAVALREGVRVDVVEFTDYVQPNIALSDKQLDANYFQHVPYLERFAGDRKLALTSAGPVHLEPLALYSTKFRQLAELPEGAQVTLPADPSNLARALRLLEAQGLLRLREDAGATATVRDVVGNPRKLDLREIDAEQQPRTLEDVAAAVINGNYFLEAQKHLKLDAKVLAREAARENPYANVLAVRQGDEQRPEVRTLVKALQSDDVRRYIESTYGGAVVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDQ2</accession>
    <name>Q1DDQ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0960"/>
    <dbReference type="EnsemblBacteria" id="ABF91904">
        <property type="protein sequence ID" value="ABF91904"/>
        <property type="gene ID" value="MXAN_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0960"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="EKEGMEH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="33784" checksum="AADBF35D4ABF0AAA" modified="2006-07-11" version="1">MMENVREIWPRDHGRFQLLSRLGRGGMAEVFLARMQQGPHAGAQVALKRVRPERLRDAEAHEQLLHEAELARCLRHPYIVGFVEYGELPDGGYLALELVEGPDLGRVLARCRRRRIELPIDISVLIVRQVLEALSHAHHAVSTTGRPLGVVHCDVSPHNVLLSRTGEVKLADFGVARSRAGAVQDIRRLGKQHYRSPELLAGDVSVAVDLWATAVLLYELLALESPFPSGPEEQVESSIRGGRVTPVRMRVPGVPDALALVLDRALAPVPSQRFGSAEQFARALAPLSDDRVATPLAVAAVVRGLMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW0</accession>
    <name>Q1DDW0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551023.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0902"/>
    <dbReference type="EnsemblBacteria" id="ABF91056">
        <property type="protein sequence ID" value="ABF91056"/>
        <property type="gene ID" value="MXAN_0902"/>
    </dbReference>
    <dbReference type="GeneID" id="41358361"/>
    <dbReference type="KEGG" id="mxa:MXAN_0902"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097817_0_0_7"/>
    <dbReference type="OMA" id="WYSRRQF"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="225" mass="25450" checksum="F5E13EAAD4F93F61" modified="2006-07-11" version="1">MIHAAKGGPLGWAWDRYIGWKFRSAFRGLWVRGALPPGGPGRLVYLNHSNWWDGFVLNQLCQTAGWDGYCLMDEENLRRYRFLTRIGAFSIRRKDATSPVASLRYAKELLRKPRAVVFVFPEGEHRPFGVLPLRLERGVELLARVSKVECLPIAVRYGFFEHERPDVLLEVGTPHPPGDMSVFQEGLETVVRRLAAVTSMEGFTRRVSGARGVAERWDAARGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW3</accession>
    <name>Q1DDW3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carotenoid biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551020.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0899"/>
    <dbReference type="EnsemblBacteria" id="ABF89363">
        <property type="protein sequence ID" value="ABF89363"/>
        <property type="gene ID" value="MXAN_0899"/>
    </dbReference>
    <dbReference type="GeneID" id="41358358"/>
    <dbReference type="KEGG" id="mxa:MXAN_0899"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739308_0_0_7"/>
    <dbReference type="OMA" id="RYTHHSF"/>
    <dbReference type="OrthoDB" id="991385at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="PTHR12726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188423" evidence="4">
        <location>
            <begin position="23"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="38869" checksum="8906049ED10975FA" modified="2006-07-11" version="1">MSALVLASLAWCAVATGFSAVACVRLSRARAGAAPQPGALPPVLLLRPVDAPTPRELENLAQSIDYAGPLEQVVVSPYRPRLAPGVRWLPSEPLTPNRKVGHLLYALDVLPVGDRVVLSVDADVAVTGALVEGLAVPVAAGAALSTAAPLPVGPRDGASRAMAGLLRYTHHSFRALDAMSAGAKAVCGKALGLSPVAVESLRRLADHIGEDLELAKRLHAQGLGVVLSSAPAVVPLDAEVLWAAPLSRFTRWMQVLASHRPALYPTVPLLFTPTLPLTVLAAALGSPVLAGSVVGLVAVRTLLALRLAGLHAPVADAGRAYAVTDWLLGEALLLAAFLRSLWRQGTVTWRGQTYVLRPGGRMIRVAPELSGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE99</accession>
    <name>Q1DE99_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF92254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92254">
        <property type="protein sequence ID" value="ABF92254"/>
        <property type="gene ID" value="MXAN_0758"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_0758"/>
    <dbReference type="HOGENOM" id="CLU_862529_0_0_7"/>
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    <dbReference type="Proteomes" id="UP000002402">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="339" mass="35031" checksum="53B373014DD43889" modified="2006-07-11" version="1">MGRPPTTRAPPRRVSPEARAVIPDLARRSGRGESDWVWISLLAALTLATQAPAAAPPPPLSVLVAPPDAAGAPSHVVEFAQEHVAEQLRARGLVVVRIEDITRKLSATKRRPLLRCNRTAPSCIRSLGAAGKTELVLVTELGQLLSGYRTGARIYTANDGALVTEHLIPGVSEDQLLDSLTQSIDAVLPVAQTALRGPPPAPPQAEPPPPPVAVVEAKPLAPELEPEPIRPLRRWAWLPAAGGVALAGVGTVFYLQAGDKYSRLDKGGAPDAPLDNADGLASSGRRAQTLSRVAIGLGAAGLVAGAVMFLLPGELPAKVQPSAAVVPGGGMVGLSGTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0743"/>
    <dbReference type="EnsemblBacteria" id="ABF92928">
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    </dbReference>
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        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="29022" checksum="75D92A077179F358" modified="2006-07-11" version="1">MLSVPAHMSRSRDRGDDFQRHFEGAQTLDGLLDLADSGLDSAQVLERMRDARAEGTPPSDVIPALFDEEPRFPSPEIARRLYQNLLGLWDLVAEGKRVRLEDEARPPRPKKVKASAPAPFHPGTPTGEFVEAAWRYLEDDEKTRTRFTHAFENRQDALLGALDAAALTDEGYGVARHLLLELYAMLELGWPPGLTSVKPAVLEADTDAPPVPQPLKDYADEALFEAEQDEEQPLSSQELEAVRRLVHRGLAALWGARKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEC2</accession>
    <name>Q1DEC2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DK1622</strain>
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    <dbReference type="EnsemblBacteria" id="ABF89979">
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        <property type="gene ID" value="MXAN_0735"/>
    </dbReference>
    <dbReference type="GeneID" id="41358206"/>
    <dbReference type="KEGG" id="mxa:MXAN_0735"/>
    <dbReference type="eggNOG" id="COG3005">
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    </dbReference>
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    <dbReference type="OMA" id="SCHKSYP"/>
    <dbReference type="OrthoDB" id="324787at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="631" mass="69210" checksum="537EE4AEE3D52C81" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEJ6</accession>
    <name>Q1DEJ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0659"/>
    <dbReference type="EnsemblBacteria" id="ABF90897">
        <property type="protein sequence ID" value="ABF90897"/>
        <property type="gene ID" value="MXAN_0659"/>
    </dbReference>
    <dbReference type="GeneID" id="41358134"/>
    <dbReference type="KEGG" id="mxa:MXAN_0659"/>
    <dbReference type="eggNOG" id="COG1574">
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="117"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="600" mass="64306" checksum="C0B0345097CCBA3E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ7</accession>
    <name>Q1DEZ7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_0507</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92791">
        <property type="protein sequence ID" value="ABF92791"/>
        <property type="gene ID" value="MXAN_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0507"/>
    <dbReference type="HOGENOM" id="CLU_511739_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="532" mass="55416" checksum="05BC798E3A56180A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF37</accession>
    <name>Q1DF37_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF89948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550599.1">
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0466"/>
    <dbReference type="EnsemblBacteria" id="ABF89948">
        <property type="protein sequence ID" value="ABF89948"/>
        <property type="gene ID" value="MXAN_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="41357959"/>
    <dbReference type="KEGG" id="mxa:MXAN_0466"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506907_0_0_7"/>
    <dbReference type="OMA" id="RMQEPIR"/>
    <dbReference type="OrthoDB" id="1352389at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="526" mass="54100" checksum="BF91D88A1AE343BF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFD8</accession>
    <name>Q1DFD8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 4 pilus biogenesis operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92453">
        <property type="protein sequence ID" value="ABF92453"/>
        <property type="gene ID" value="MXAN_0361"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_0361"/>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
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        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="19023" checksum="9E9DAA2B5FC544CF" modified="2006-07-11" version="1">MTALKRRQHRGITLLEVLATMAILLMGVGAAMLVVTQTSYSNRRSLSATQAQLIAEQAMENITLLGCSVQPPCGNLEGLDESYVLFQTSAGALSNVRPADPTVIAREYQVVVDVDVPSILSTIEPGSLVPEELQRDLVPGVPDTAGNIANVRVVVSWQEQERSDRQVVVLQTRMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFX6</accession>
    <name>Q1DFX6_MYXXD</name>
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        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">MXAN_0164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550311.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0164"/>
    <dbReference type="EnsemblBacteria" id="ABF90399">
        <property type="protein sequence ID" value="ABF90399"/>
        <property type="gene ID" value="MXAN_0164"/>
    </dbReference>
    <dbReference type="GeneID" id="41357667"/>
    <dbReference type="KEGG" id="mxa:MXAN_0164"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_7"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="573" mass="60093" checksum="B99C73608042D0D6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY8</accession>
    <name>Q1DFY8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550299.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0152"/>
    <dbReference type="EnsemblBacteria" id="ABF89458">
        <property type="protein sequence ID" value="ABF89458"/>
        <property type="gene ID" value="MXAN_0152"/>
    </dbReference>
    <dbReference type="GeneID" id="41357655"/>
    <dbReference type="KEGG" id="mxa:MXAN_0152"/>
    <dbReference type="HOGENOM" id="CLU_1146642_0_0_7"/>
    <dbReference type="OMA" id="QQWAAYL"/>
    <dbReference type="OrthoDB" id="1278088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="26016" checksum="AB7FC378BA68D9DF" modified="2006-07-11" version="1">MSGGALYQESLRALRRLGLPEVSERDVLAALEAAQPGPLSLFYEAGAEAGLPREALMARGAGLFLSFSAGNLADDLIDGECTYHDPPIRVGPCVQFILQNLAFATLCGAPAQLPGTVLEEAVRTLAVAAGPQALEVRASDWTAPLFRQVAEGIAGQQWAAYLRVLWAGTVLEPRAAAAGRALGVAAHVAEDIRTRDVRFTSMPGADRHAVVAWARAAAQALRRLDLRCLDAALRRIEPMLPEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFZ4</accession>
    <name>Q1DFZ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550293.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0146"/>
    <dbReference type="EnsemblBacteria" id="ABF86669">
        <property type="protein sequence ID" value="ABF86669"/>
        <property type="gene ID" value="MXAN_0146"/>
    </dbReference>
    <dbReference type="GeneID" id="41357649"/>
    <dbReference type="KEGG" id="mxa:MXAN_0146"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009622_0_0_7"/>
    <dbReference type="OMA" id="WTIFASA"/>
    <dbReference type="OrthoDB" id="98200at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1059" mass="112958" checksum="7BFA6C6695817009" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGA3</accession>
    <name>Q1DGA3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aliphatic sulfonates ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0037"/>
    <dbReference type="EnsemblBacteria" id="ABF90578">
        <property type="protein sequence ID" value="ABF90578"/>
        <property type="gene ID" value="MXAN_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0037"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="LMPWRSA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="259" mass="28292" checksum="BD36B9399A820269" modified="2006-07-11" version="1">MVALQNVDLNVRSGEFVCLLGPSGCGKSTLLYALAGHVVPTGGSVSIDRHPIHGPGPDRLLMFQEAALFPWLTVRGNITFALAARGVPRAERRERADTYIRRVQLGGFEDALPHQLSGGMKMRASLARALAVDPAVLLMDEPFGSLDAQTRIHMQELLQSIWVRTGKTVVFVTHDVHEALMLGTRVVLMAPRPGRVVRDLEVHLPMPRQPEDAALNEMVRHVGGLLREVEGRAHTRSLQPAPTRAPAQPVLRPQVIPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGC8</accession>
    <name>Q1DGC8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxD-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0012"/>
    <dbReference type="EnsemblBacteria" id="ABF92697">
        <property type="protein sequence ID" value="ABF92697"/>
        <property type="gene ID" value="MXAN_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0012"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_3_4_7"/>
    <dbReference type="OMA" id="VKWGGGF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20201" checksum="CC7727E94622AB27" modified="2006-07-11" version="1">MPDPTYPGFRQRPRPIQGVAGMNVATLTEQPSILKAAALLPPRLSLGSTMVVHGVSKLRAEGTAQHADLFEQLGFKPGKPWVIATGVVELLSGVSSILGIATRPAALAILVTQAIAVAKVHGSKGFDITKGGFEFNLALGAIALGLLLRGPGPLSVHSAIERRVKRKELRRLRFLPRQRRRSVLLDVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ9</accession>
    <name>Q1CVJ9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7470"/>
    <dbReference type="EnsemblBacteria" id="ABF93117">
        <property type="protein sequence ID" value="ABF93117"/>
        <property type="gene ID" value="MXAN_7470"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7470"/>
    <dbReference type="HOGENOM" id="CLU_3382852_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="33" mass="3726" checksum="6B88DDC565A2D08F" modified="2006-07-11" version="1">MKERTLPARPQRLVSTPGVEPRPGLNREILQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVW7</accession>
    <name>Q1CVW7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557261.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7348"/>
    <dbReference type="EnsemblBacteria" id="ABF89048">
        <property type="protein sequence ID" value="ABF89048"/>
        <property type="gene ID" value="MXAN_7348"/>
    </dbReference>
    <dbReference type="GeneID" id="41364509"/>
    <dbReference type="KEGG" id="mxa:MXAN_7348"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120970_0_0_7"/>
    <dbReference type="OMA" id="DMWRMLT"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="18723" checksum="74FB01EF42565096" modified="2006-07-11" version="1">MHPHAQLITDFYSAFQRRDAQAMAACYHPEVEFSDAAFVGLRRREPGAMWLMLCERGKDLEVTFRDVQADDHRGRAHWDANYTFSGTGRKVLNRIDAEFEFRDGKIVRHRDHFDFWTWSRQALGPTGLVLGWTPLLKKKVQSKARKSLDIFMRERGIPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVZ8</accession>
    <name>Q1CVZ8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557231.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7312"/>
    <dbReference type="EnsemblBacteria" id="ABF88833">
        <property type="protein sequence ID" value="ABF88833"/>
        <property type="gene ID" value="MXAN_7312"/>
    </dbReference>
    <dbReference type="GeneID" id="41364475"/>
    <dbReference type="KEGG" id="mxa:MXAN_7312"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_2_0_7"/>
    <dbReference type="OMA" id="NYLVMLA"/>
    <dbReference type="OrthoDB" id="1102730at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="31973" checksum="891EDB63BEEC7664" modified="2006-07-11" version="1">MDISWDDARLFLAIAETGSFSGAARQLRIGQPTVSRRLAALEYAVGASLFRRGVDGAVLTAAGERLVLPAKKMAEWAGELHRAAESSDTSPRGLVRVTAAPYMCFDFLAPFSGAVAKKHPGLRLEVLSGIQYLDLGRGEADLALRARCPPNADLKRVYGVQIRNAVFVAKSLKAKLPKRPTLQQIPWVAWAPPFDATPPNPQLESIIPGFSPVFTADNYLVMLAAAEAGVGAMVLGDLRHRFVRERSLVPLDLDLGPYATSELHLVCAKSALDIPRVRKVSELLVEELEQAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW12</accession>
    <name>Q1CW12_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557217.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7298"/>
    <dbReference type="EnsemblBacteria" id="ABF90377">
        <property type="protein sequence ID" value="ABF90377"/>
        <property type="gene ID" value="MXAN_7298"/>
    </dbReference>
    <dbReference type="GeneID" id="41364461"/>
    <dbReference type="KEGG" id="mxa:MXAN_7298"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_7"/>
    <dbReference type="OMA" id="CDFARDV"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="429" mass="48315" checksum="CA85A6E26FF2EDCE" modified="2006-07-11" version="1">MPVSVQKQEETGVPAHASAGRCPHLGAQYNPFTGPHAEDPHAFFEKLRKDEPVSFSPMLNMWLVSRYEDISQVLKSPAQYSNRDMLASGTHLTDEAKAILDQGFPTAHVLLGMDPPEHTRLRRLMNRGFTAQRIAGMGPFIREMATTLVDRFAQDGEADLVKQLAWPLPVHVILGVMGVPQEDVWKIKRWSSDWQQLVFEYVAPELQVEMAKGVIEFQQYCIRLIEDRKKNPQEDLTSYLVAVESDGEALTMHELVMAVGASMLSAGHESTTALMANAWKLALQHGLWQRLRDNRDLVPKFLEESSRYDSVSHAMIRTAKEDVELGGVKIPQGSRLLLLFAAGSRDESLCPHSSKLDVDREKVPQHLTYGRGTHFCLGAPLARLQFEITTNILLDRLPDPKLVPGQDFGTWQSLVLRQMKHLKVEWTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWI0</accession>
    <name>Q1CWI0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88758">
        <property type="protein sequence ID" value="ABF88758"/>
        <property type="gene ID" value="MXAN_7130"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7130"/>
    <dbReference type="HOGENOM" id="CLU_3101223_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="51" mass="5335" checksum="B61E36B860950B04" modified="2006-07-11" version="1">MSGLAGENRLSSRADSSSPHATASKKGAARLVNFFVSSEAREKNTKARALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ3</accession>
    <name>Q1CWJ3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557036.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7117"/>
    <dbReference type="EnsemblBacteria" id="ABF87826">
        <property type="protein sequence ID" value="ABF87826"/>
        <property type="gene ID" value="MXAN_7117"/>
    </dbReference>
    <dbReference type="GeneID" id="41364291"/>
    <dbReference type="KEGG" id="mxa:MXAN_7117"/>
    <dbReference type="eggNOG" id="ENOG5032WSW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751888_0_0_7"/>
    <dbReference type="OMA" id="RTGFEIC"/>
    <dbReference type="OrthoDB" id="553959at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="368" mass="41806" checksum="5E9BDE633CC8AB94" modified="2006-07-11" version="1">MSNFRRATRDDNTALLDLFGTVPMQGDLVLSAQRAPDYFGLYTMQRGETEVWVHGEHGRLDGMGAVHVRDGWLEGRPCRVGYLGDLRTRFSARRNRGLARFYGPMIEESAQRLGVDTFLTAVMASNAPALHALVRRRPGRVSQPHYTLLRRFSAVSIQFLLRRRPRRSAVTVRRATPADVPAVSALLDADHRARPFGYRFDTGELEHRLAHWPGLRIEDTYLAFDATGALVGCTTAWNPEAVKRYRVHAYRGGMRWVRWGWDTLATALRAPRLPAPGSDFRYFYLCNTSVRGEDPAVLRALVERVYADFHGQGFHFFTLYQDELDPLAPALKGFLQRRLDFHLYAVTPASRPRETFPAGRTGFEICLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWY2</accession>
    <name>Q1CWY2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6976"/>
    <dbReference type="EnsemblBacteria" id="ABF87525">
        <property type="protein sequence ID" value="ABF87525"/>
        <property type="gene ID" value="MXAN_6976"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6976"/>
    <dbReference type="eggNOG" id="ENOG50340YK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939802_0_0_7"/>
    <dbReference type="OMA" id="AYQHFRG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29127" checksum="E2331C60854BB541" modified="2006-07-11" version="1">MSMGTEQPFSGRLRVSSTVRGWGHTVGEEGVDALRLREARMDLAVAYAPLPWLFLSATLPLQAREVRHVSLARDRGWGIGDVEVAAKVFLFQDKAFSADHLFSALGGVKLPTAPVLRGPDGAQLALDSQLGSGSVDPLAGLAYQHFRGSWSFLASATSFFPTRGIQGFRAGASLRTTLAAQYQPSARWALRLGFDSRLEAPADSKGEHQGHTDSERHEHTGGFIGYASPDVIFSPGMDVVVAAGVRVPFINQLRGRVVPTPIAMLSVAYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI8</accession>
    <name>Q1CXI8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CrtC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556693.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6767"/>
    <dbReference type="EnsemblBacteria" id="ABF91081">
        <property type="protein sequence ID" value="ABF91081"/>
        <property type="gene ID" value="MXAN_6767"/>
    </dbReference>
    <dbReference type="GeneID" id="41363958"/>
    <dbReference type="KEGG" id="mxa:MXAN_6767"/>
    <dbReference type="eggNOG" id="COG5621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040626_0_0_7"/>
    <dbReference type="OMA" id="AWLDHEW"/>
    <dbReference type="OrthoDB" id="591394at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
        <property type="entry name" value="AttH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07143">
        <property type="entry name" value="CrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CrtC" evidence="2">
        <location>
            <begin position="76"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="412" mass="45260" checksum="C9DA34C726355102" modified="2006-07-11" version="1">MSNGRGLVVGTVVVLVGLAAAVVAITREQPLPALRQGGTLTVASAMSGSTEGYARAKEPRDFHFPEDHGPHPEYRTEWWYWTGNLETEDGRAFGYQFTLFRNALAPEAAPRDSAWGASQVYMGHFAVTDVASGGFHASERFSRVALGLSGATSQPFKVWLEDWEAASAGPSTWPMRLRARTDAVTLELLLEPGKPPVLQGDRGLSQKSAERGNASYYYSMTRMPSRGTVRVDGRTYAVKGHSWMDREWSTSALGATQVGWDWFSLQLSDGSELMYYQLRHRDGSPDAFSTGLWVPPEGTGEAVHVGRDDMKLTVLDTWKSPHSGGEYPSRWRMQVDSLGLDLTVTPRLADQELPVSVLYWEGTVGLEGTRAGQPLTGRGYVELTGYADTQGPRRRESQARGAPDAQTTQNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY09</accession>
    <name>Q1CY09_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6594"/>
    <dbReference type="EnsemblBacteria" id="ABF86674">
        <property type="protein sequence ID" value="ABF86674"/>
        <property type="gene ID" value="MXAN_6594"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6594"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283966_0_0_7"/>
    <dbReference type="OMA" id="TYRYPAY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012683">
        <property type="entry name" value="CHP02302_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13779">
        <property type="entry name" value="DUF4175"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1014"/>
        </location>
    </feature>
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        <location>
            <begin position="564"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116029" checksum="D34FB7C0B40DE38E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Putative lipoprotein</fullName>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="53123" checksum="7904D115B037E6C4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY52</accession>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ROK family</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">MXAN_6549</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF87082">
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        <property type="gene ID" value="MXAN_6549"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_036604_13_3_7"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
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        <source>
            <dbReference type="EMBL" id="ABF87082.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY65</accession>
    <name>Q1CY65_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_6536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6536"/>
    <dbReference type="PeroxiBase" id="4363">
        <property type="entry name" value="MxBCP01"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92565">
        <property type="protein sequence ID" value="ABF92565"/>
        <property type="gene ID" value="MXAN_6536"/>
    </dbReference>
    <dbReference type="GeneID" id="41363743"/>
    <dbReference type="KEGG" id="mxa:MXAN_6536"/>
    <dbReference type="eggNOG" id="COG1225">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_7"/>
    <dbReference type="OMA" id="ISTHCFQ"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="17645" checksum="79175B5CFB4D808F" modified="2006-07-11" version="1">MAKTKLLKQGDAVPDITLTGAGGQSVRLRDLVGQKVLVVYFYPKDDSPGCTAQACGLRDQYEDFVAAGAEVVGISGDSVGSHEGFAAKHRLPFKLLSDARGEAREAFGVSSSFLGLLPGRVTFVVDRSGIVRDSFESQIRVGEHVRRALELVRALAQEGGAPASAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYT0</accession>
    <name>Q1CYT0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6318"/>
    <dbReference type="EnsemblBacteria" id="ABF88807">
        <property type="protein sequence ID" value="ABF88807"/>
        <property type="gene ID" value="MXAN_6318"/>
    </dbReference>
    <dbReference type="GeneID" id="41363534"/>
    <dbReference type="KEGG" id="mxa:MXAN_6318"/>
    <dbReference type="eggNOG" id="ENOG5031DJK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2735822_0_0_7"/>
    <dbReference type="OMA" id="GARKHDG"/>
    <dbReference type="OrthoDB" id="2104546at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188052" evidence="2">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="8483" checksum="434E280FCB9A8518" modified="2006-07-11" version="1">MSWPRTMKARLLLPVLALFTFSGCFHHHHYDSRPPKSKKSKRSSKHCHPSQYWDGTECKHKGKGKGARKHDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYX1</accession>
    <name>Q1CYX1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556213.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6275"/>
    <dbReference type="EnsemblBacteria" id="ABF90462">
        <property type="protein sequence ID" value="ABF90462"/>
        <property type="gene ID" value="MXAN_6275"/>
    </dbReference>
    <dbReference type="GeneID" id="41363495"/>
    <dbReference type="KEGG" id="mxa:MXAN_6275"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_0_7"/>
    <dbReference type="OMA" id="RGRDAQW"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="117" mass="13550" checksum="D7CBCB7F721F35A8" modified="2006-07-11" version="1">MIETFTALADPNRFRIVEYLLGGARSVGAIGEALNLNQPQVSKHLRVLKEARLVDVEARAQQRLYGLRPEPLRELNAWLERYRDIWDERLGQLDSLIEELKTQDMEAAQRHARKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ27</accession>
    <name>Q1CZ27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556159.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6215"/>
    <dbReference type="EnsemblBacteria" id="ABF89618">
        <property type="protein sequence ID" value="ABF89618"/>
        <property type="gene ID" value="MXAN_6215"/>
    </dbReference>
    <dbReference type="GeneID" id="41363442"/>
    <dbReference type="KEGG" id="mxa:MXAN_6215"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_7"/>
    <dbReference type="OMA" id="MNLRRDV"/>
    <dbReference type="OrthoDB" id="1617768at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="124" mass="13944" checksum="F0D570264728F62F" modified="2006-07-11" version="1">MVTPMVQQRSEQLDAVFHALSDPTRREMLRSLSSGPRSIGELAAPFSMSFAGASKHVKTLERAGLVNRSVEGRTHRCSLAPAPLAGAADWLRFYERFWNDRLDALERELRKPERGSARKGARHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA2</accession>
    <name>Q1CZA2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6140"/>
    <dbReference type="EnsemblBacteria" id="ABF86037">
        <property type="protein sequence ID" value="ABF86037"/>
        <property type="gene ID" value="MXAN_6140"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6140"/>
    <dbReference type="eggNOG" id="COG3463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567210_0_0_7"/>
    <dbReference type="OMA" id="CKEEFAF"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="480" mass="53849" checksum="A0676F710ED0CD68" modified="2006-07-11" version="1">MVPSISDSSPGRVRHGLGAMALLLVVLIWGVFVVVPVWLQAAQVCFPNFDLGIYSQAVARLSLAEPNPWISARQVFIFNDHFDPILWVAHPLARIIPPMWAALVVEALFVLLTVAPLLWLHLKGLLSRNALVLLAVLLLLSPSMVEAMKFPVHPTTWSVLPWVLTGLAFHLRRQGLLLASLVLLFACKEEFAFGGVMLTLALFLRGERRLATFVGALSLAWLTWVYGLRPWLLGPTVDYTFRLRQGMEGGWFHYLSLRLAPPHVSRIGTLTLLFVPLGVWAWRERLRPDWTWLLVLLPMLGIRFLAMAWRFHYGVSVVAAALMGFLPVLRTRSPPWWVIASTSVVLLASNEPNLRKLTSTLVSPQTSPRHCPRTPERLASLSRGVDMLTQHSEGSALLSSNLVTLLAHRSEIYAVGGPQPDEGRVHEWVLVEKPPHGDVWPLTSTRVRELIDVWRTDASTQVIIDDENVFMARGRFTAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZA6</accession>
    <name>Q1CZA6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig-like domain/kelch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="COG3055">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF117281"/>
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    </dbReference>
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        <property type="entry name" value="SSF49313"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="879" mass="88279" checksum="A2233E88AD01E65D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZD2</accession>
    <name>Q1CZD2_MYXXD</name>
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        <submittedName>
            <fullName evidence="12">Matrix-associated zinc metalloprotease FibA</fullName>
        </submittedName>
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    <gene>
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        <name evidence="12" type="ORF">MXAN_6106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF90985">
        <property type="protein sequence ID" value="ABF90985"/>
        <property type="gene ID" value="MXAN_6106"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_6106"/>
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    </dbReference>
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    <dbReference type="OMA" id="VGCNEST"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
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    </dbReference>
    <dbReference type="Pfam" id="PF07504">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="547"/>
            <end position="613"/>
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    </feature>
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        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="432"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="744" mass="79807" checksum="FEC14996880BCB97" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR3</accession>
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        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">MXAN_5975</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_5975"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ASH"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15780">
        <property type="entry name" value="ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASH" evidence="2">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="998" mass="105600" checksum="1F0E542989D87377" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZS8</accession>
    <name>Q1CZS8_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555909.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5958"/>
    <dbReference type="EnsemblBacteria" id="ABF90435">
        <property type="protein sequence ID" value="ABF90435"/>
        <property type="gene ID" value="MXAN_5958"/>
    </dbReference>
    <dbReference type="GeneID" id="41363197"/>
    <dbReference type="KEGG" id="mxa:MXAN_5958"/>
    <dbReference type="eggNOG" id="ENOG5030SST">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917733_0_0_7"/>
    <dbReference type="OMA" id="NPLRMGR"/>
    <dbReference type="OrthoDB" id="912040at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="33742" checksum="B6A954366E3F222F" modified="2006-07-11" version="1">MSDVRFIVARPDSLGPYVERLRLLEREILYPLADGADHFFIDHGPGYHPFFSSMGEAYFLLALRGDDLLGSVTGVLRPVWHGTRKVDALYICDLKLAKHARGSGLSTKLLLQGLKHLFLIPPLRRIRFLYGAAMRGARGDVMRIARGWNPLRMGRPASQLALYFVPPARLQAVDTRSAPPRPTGAGLRLGPAPARTLEGAGWCTTAGAKDLQRLSTGRPWPLVHLAAPPEAWTQGWGEYLRTCGVELAALGEEALACFSIDERLEDHVHWLREVGIAPDSVCTVYSLDLSFPARAPAWVHLPSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZT2</accession>
    <name>Q1CZT2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555905.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5954"/>
    <dbReference type="EnsemblBacteria" id="ABF86781">
        <property type="protein sequence ID" value="ABF86781"/>
        <property type="gene ID" value="MXAN_5954"/>
    </dbReference>
    <dbReference type="GeneID" id="41363193"/>
    <dbReference type="KEGG" id="mxa:MXAN_5954"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_7"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="OrthoDB" id="854580at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="696" mass="76641" checksum="9D06806E7CAFCCDF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0J6</accession>
    <name>Q1D0J6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5689"/>
    <dbReference type="EnsemblBacteria" id="ABF87915">
        <property type="protein sequence ID" value="ABF87915"/>
        <property type="gene ID" value="MXAN_5689"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5689"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032801_0_0_7"/>
    <dbReference type="OMA" id="GREDVGC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187771" evidence="2">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C554" evidence="3">
        <location>
            <begin position="401"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="520" mass="54295" checksum="1C52206837EEEB4F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Y6</accession>
    <name>Q1D0Y6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5548"/>
    <dbReference type="ESTHER" id="myxxd-q1d0y6">
        <property type="family name" value="UCP037442"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86469">
        <property type="protein sequence ID" value="ABF86469"/>
        <property type="gene ID" value="MXAN_5548"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5548"/>
    <dbReference type="eggNOG" id="COG4757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058232_0_0_7"/>
    <dbReference type="OMA" id="PRYFFDD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017208">
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    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037442">
        <property type="entry name" value="UCP037442_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="32391" checksum="8BC7CFDFD65CE69B" modified="2006-07-11" version="1">MPAPVATASPEVVRIPARDGLPLAATVYQGLQDNGVVVQINPATAVPRRYYDAFARFLAGRGFTVVTYDYRTMGDSVVDASLRNQARFQDWGELDTPAVLDWVTARFPSHRLAVVGHSAGGQMLGLAENASRIQSVLLIGSQHGWWRHWPLRQGLALAAIWYVALPASVALLGYFPGRAVGSEDLPGGIAKQWARWCRNRHYVSDDNGAPLRPYNDRVRARIRLYSFSDDAIAPEAAARALLDYYPNATREHLHRTPAELGMKRIGHFGWFRSSMPEVVWVEAADWLEQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D198</accession>
    <name>Q1D198_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5428"/>
    <dbReference type="EnsemblBacteria" id="ABF91190">
        <property type="protein sequence ID" value="ABF91190"/>
        <property type="gene ID" value="MXAN_5428"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5428"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_1_7"/>
    <dbReference type="OMA" id="QVWPGHG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="263"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="365"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="483" mass="52962" checksum="1332680AD4EBB6A8" modified="2006-07-11" version="1">MYFQAIKTAGLAQITYILGSEGEALVVDPRRDVDVYLDVLRRQELRLRYVLQTHRQEDFVEGTSALARLAGAQVVAGRHPITGHADVRMGERERLHLGALTLVALHTPGHTPESMSWAVYLDPHHAQAWGVFTGDALLAGETGRTDLAAPERVYENAALLFDSLHQKVLPLGDQTLVFPAHGAGSVCRSGIADRELTTLGFERLHNPVFTSSRSDFIQRKVQERLHRPSYFSRMEEVNIRGGVPLSADSSAIPFLEPKRFQWESHSGLVLDVREPESFAGGHIPGSLNVWMQGLSVFGGQMVQPGTPLFLVLPAHVDSKEAVLALARVGLDQVEGILTGGFGAWRNAGLPIESSGTLTPEALFSQWEGFQVLDVRERSEFERGHILSARHAYVTELEECLSELGLREDHPVAVVCSTGHRSGLATSILLRNGFQQVSNVLGGMSAWRRLELPVRTGPPSEVEFEQATRSMGTEEQDASPPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1E3</accession>
    <name>Q1D1E3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555345.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5380"/>
    <dbReference type="EnsemblBacteria" id="ABF91465">
        <property type="protein sequence ID" value="ABF91465"/>
        <property type="gene ID" value="MXAN_5380"/>
    </dbReference>
    <dbReference type="GeneID" id="41362648"/>
    <dbReference type="KEGG" id="mxa:MXAN_5380"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283112_0_0_7"/>
    <dbReference type="OMA" id="QLGWGPA"/>
    <dbReference type="OrthoDB" id="73116at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
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        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188012" evidence="1">
        <location>
            <begin position="23"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="966" mass="101316" checksum="F6F2D5D50C507CAC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F9</accession>
    <name>Q1D1F9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding reponse regulator HsfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hsfA</name>
        <name evidence="8" type="ORF">MXAN_5364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D1F9"/>
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    <dbReference type="EnsemblBacteria" id="ABF86053">
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        <property type="gene ID" value="MXAN_5364"/>
    </dbReference>
    <dbReference type="GeneID" id="41362632"/>
    <dbReference type="KEGG" id="mxa:MXAN_5364"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="QAPIYIS"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="148"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="485" mass="53189" checksum="67EF03821E6996BE" modified="2006-07-11" version="1">MNQVKRAKVLVVDDDSVVLKAVTQILQREGHPVVAIDDAVEGLAAAKDPTIDVVVLDIKMPNLSGMDLLRGIKADRPDVEVIMMTAFATVETAVEAVKAGAYDYLTKPFENIDEVSLTVAKAAERKALKDRTRALEEALTVRSQFEDLIGQSTQMRSVFKLVETVSHSTATVLIQGESGTGKELVARAIHYRSARKDKPFVAVNCSALTETLLESELFGHVKGSFTGATGNKKGLFEAADGGTIFLDEIGDVPPATQVRLLRVLQEGEVKRVGANEPVKVDVRVIAATHVDLSRAKEQGKFREDLFYRLNVITIDLPPLRDRPEDVPLLAHHFLKLYASKADKKVTGISPRAMEALTCNRWTGNVRELENVIERAVVLTGNEVIDVEDLPPGFQSAPQPDSTVEVFSLAHLPYAQAKRLAMRAFERRYLSALLEKNNQNVSSAARAAGVDRSNFRRLLKQYEVAGRSMKPRVVSQDDGEALEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D291</accession>
    <name>Q1D291_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rpsF</name>
        <name evidence="8" type="ORF">MXAN_5078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555052.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5078"/>
    <dbReference type="EnsemblBacteria" id="ABF89616">
        <property type="protein sequence ID" value="ABF89616"/>
        <property type="gene ID" value="MXAN_5078"/>
    </dbReference>
    <dbReference type="GeneID" id="41362362"/>
    <dbReference type="KEGG" id="mxa:MXAN_5078"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_4_0_7"/>
    <dbReference type="OMA" id="ETIFLVK"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17698" checksum="CA07C33FF3B5EA3C" modified="2006-07-11" version="1">MAETQAATRLREYETIFLVKPDLTDDNVDKLKERVRGIVSREGGKVIRFTVWGKKKTLFPVAKQPRAIYVHTHFLGGAKLVAEIERNLRNLDEVTRYISVKLADEVDPETRPVLEDVKLAGDVEETRPGAPAEREGGFRSEGSEEQGGDSEEESSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E5</accession>
    <name>Q1D2E5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TonB dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5023"/>
    <dbReference type="EnsemblBacteria" id="ABF87796">
        <property type="protein sequence ID" value="ABF87796"/>
        <property type="gene ID" value="MXAN_5023"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5023"/>
    <dbReference type="eggNOG" id="COG3827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_17_0_7"/>
    <dbReference type="OMA" id="IREDGPN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188051" evidence="6">
        <location>
            <begin position="22"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="408"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="802" mass="86474" checksum="83E27A0E2EF4D5C6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2V7</accession>
    <name>Q1D2V7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554841.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87272">
        <property type="protein sequence ID" value="ABF87272"/>
        <property type="gene ID" value="MXAN_4858"/>
    </dbReference>
    <dbReference type="GeneID" id="41362151"/>
    <dbReference type="KEGG" id="mxa:MXAN_4858"/>
    <dbReference type="eggNOG" id="ENOG5032ETA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773321_0_0_7"/>
    <dbReference type="OMA" id="LKVMHVI"/>
    <dbReference type="OrthoDB" id="641382at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030824">
        <property type="entry name" value="CHP04562"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04562">
        <property type="entry name" value="TIGR04562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="44897" checksum="F86F61D8EC62B22A" modified="2006-07-11" version="1">MGEGPRSFEKTSPSEWARLGSSSVKVPSLIPVLPDIPICTVGRMGLRELERIRLILRGGSVIDWRRMHFQSRGEVDNFLRLLQLDVSRPYDDEWARAVLAEAVEYLRKTFNYRVADAVARPEEIHDLFLYASGVKGAPRHRRIACVVLKVMHVIQHIEGRDLLFRLPVSEAELAELIMERVMGVAAEMQSKGLPIAEFAHSIKTQDSLVTKLLAKKETVAAQVYDRTRFRVVTKRREDLLPVLYYLSQRLFPFHLVVPGQTENTLMPFKAVLAENPHFEQYIPRLHLDRDYEDRENTGGNTFSGNTYRALNFVVDLPMRMDAYLPTPEEDTRQRKGRIIISLVEFQIVDEETARLNERGDNAHEAYKRRQKQRVLKRLSQGLVVPKRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z2</accession>
    <name>Q1D2Z2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysT</name>
        <name evidence="11" type="ORF">MXAN_4820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554806.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4820"/>
    <dbReference type="EnsemblBacteria" id="ABF91471">
        <property type="protein sequence ID" value="ABF91471"/>
        <property type="gene ID" value="MXAN_4820"/>
    </dbReference>
    <dbReference type="GeneID" id="41362119"/>
    <dbReference type="KEGG" id="mxa:MXAN_4820"/>
    <dbReference type="eggNOG" id="COG0555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_7"/>
    <dbReference type="OMA" id="VFISGNM"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="30605" checksum="BA3FD6385DB1F70F" modified="2006-07-11" version="1">MSRPTRHQVLPGFRLSLGFSWFYLGLIVLIPLSSLFLRTFSLSWEEFWGTVTTPRALAAYRLSFGASLAAALANVVFGLLVAWVLVRYRFPGRDVLESLVDLPFALPTAVAGLTLTTLFSAKGWYGQHLEALGLKVAYTSVGVAIALTFIGLPFVVRTVQPVLEDIDVDVEEAAATLGASPWQTFRRVLFPALFPALLSGFTLAFARALGEYGSVVFISGNMPLRTEIVPLLIITRLEQFDYAGATAIAIVMLGASFSLLLAVNLLHRWSQRRLEARPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3B3</accession>
    <name>Q1D3B3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">MXAN_4694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554685.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4694"/>
    <dbReference type="EnsemblBacteria" id="ABF91021">
        <property type="protein sequence ID" value="ABF91021"/>
        <property type="gene ID" value="MXAN_4694"/>
    </dbReference>
    <dbReference type="GeneID" id="41361993"/>
    <dbReference type="KEGG" id="mxa:MXAN_4694"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_7"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="371" mass="39637" checksum="A7B0DABEDEFFA323" modified="2006-07-11" version="1">MGAATSATPVSSRLSDYDFALPESQIAQAPLAERDASRLMTISRSSGTWSHRRFADLQELLRPGDLLVLNDARVIPARLLGQKAGTGGRVELLVVRPAAQNTLTSAALGAAPESLDWVCLGQASKGLKPGQRVMFASGLEAEIQEALGGGEYRVRFHAPPGASLAALLDAAGRLPLPPYITREPDAADAERYQTVYARASGAVAAPTAGLHFTQETLAALAARGVHRALVTLDVGPGTFLPVREDDLDKHHMHPERYTVPEATAKAINAARAEGRRVVAVGTTVVRTLESATDPETGRLRAGPGETTLFIRPGFAFRQVDLLLTNFHLPRSTLVVLVSALLGRERTLEAYAEAVRAGYRFFSYGDAMLVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3C9</accession>
    <name>Q1D3C9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554669.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4678"/>
    <dbReference type="EnsemblBacteria" id="ABF87054">
        <property type="protein sequence ID" value="ABF87054"/>
        <property type="gene ID" value="MXAN_4678"/>
    </dbReference>
    <dbReference type="GeneID" id="41361976"/>
    <dbReference type="KEGG" id="mxa:MXAN_4678"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_7"/>
    <dbReference type="OMA" id="DRFMFAI"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="33946" checksum="B88A8520A04EEFC3" modified="2006-07-11" version="1">MSDASPLSRLTAALDAAVFGQQRVLEDLVTAFLARGHVLLEGVPGVAKTLTARSMAGALGLLFTRIQFTPDLMPADILGTNVFQPQDHAFRLVKGPIFTEVVVADEINRTPPKTQAALLEAMEERQVTIDGVSHALPPHFFVVATQNPLELEGTYPLPEAQLDRFLMRVRVGYPEASAETTMLRAFHQREGKPATTRQVLDAPTLLELQSRAARVSCDDSIIQYVVAIVRETRTNPRVRLGASPRSAQALLAASKARAALMGTDFVTPDDVKAVTFSVLNHRLLLKAEAEVEGITADDVLKQTLERVRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3K7</accession>
    <name>Q1D3K7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554593.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4598"/>
    <dbReference type="EnsemblBacteria" id="ABF89956">
        <property type="protein sequence ID" value="ABF89956"/>
        <property type="gene ID" value="MXAN_4598"/>
    </dbReference>
    <dbReference type="GeneID" id="41361898"/>
    <dbReference type="KEGG" id="mxa:MXAN_4598"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_2_2_7"/>
    <dbReference type="OMA" id="DDEAMTY"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1515" mass="168448" checksum="665E8402F0880E7C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Y2</accession>
    <name>Q1D3Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554468.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4470"/>
    <dbReference type="EnsemblBacteria" id="ABF92264">
        <property type="protein sequence ID" value="ABF92264"/>
        <property type="gene ID" value="MXAN_4470"/>
    </dbReference>
    <dbReference type="GeneID" id="41361780"/>
    <dbReference type="KEGG" id="mxa:MXAN_4470"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049717_0_0_7"/>
    <dbReference type="OMA" id="YFDNTYM"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="35218" checksum="89DCEAD37F537984" modified="2006-07-11" version="1">MGTVALFGATGVVGHSIAQALWGQGRGYRVVGRSREGLQREFGADPQAEIVTWNPDDMASIQAAARGVQTLIYLVGVPYWQFHLHPVLMKRTLDAAIAEGVERIVFIASVYPYGRPRTDVVNESHPRVPHTNKGRLRKAQEDLLLAADKAGSIQVTILRLPDFYGPGVENSFLHRAFVAASQGKRAQLIGPIDTPHEFVYVPDVGPTVTALMDHPGAYGRFWNLGGAGVTSQAALVEDIYAQAGHPAKYSVLGPGMVRLIGLFSPFMRELGEMHYLHTSPVIMDDSALRALLGDIRKTPYRDGIRQTLAALSPAPVATGHPHPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Y3</accession>
    <name>Q1D3Y3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4469"/>
    <dbReference type="EnsemblBacteria" id="ABF88011">
        <property type="protein sequence ID" value="ABF88011"/>
        <property type="gene ID" value="MXAN_4469"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4469"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670326_0_0_7"/>
    <dbReference type="OMA" id="IVLYQKN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="372" mass="40316" checksum="6E1B4AB93B6FFDDE" modified="2006-07-11" version="1">MRGVDNEVRGFICRGPMGMRTSKRTGVSGMEALDAAAEAFETGDFEAALAAADRGLAQAPDSVDALHLRAAALVELGRLEEAGRAFGAALRVSPDDLEVLLGTADCLICRAGEDREAVEEGLGFCAKGKRLAQKAGDVELLYEFLLLEGMGLNQVGECRAALASLDAALGHMPRSVDAQLERGIALFELCRFDDAKGAFDKVLKDTPDEAWAHQYLGLMAERRGDEKEAQRRFAKAQALVPTEFFPPVELGEAEFDRAVEAAVQSLPGHAKQYLDNVTIAVEDLPADEDLLGEDPPLSPSILGVFRGLAVGERSVTNAFDHVPASIVLYQKNLERFARTREELIEQIGITVMHEVGHLMGLDEDDLWQRGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4A4</accession>
    <name>Q1D4A4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II glutamine amidotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554347.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4346"/>
    <dbReference type="EnsemblBacteria" id="ABF87458">
        <property type="protein sequence ID" value="ABF87458"/>
        <property type="gene ID" value="MXAN_4346"/>
    </dbReference>
    <dbReference type="GeneID" id="41361658"/>
    <dbReference type="KEGG" id="mxa:MXAN_4346"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042555_0_0_7"/>
    <dbReference type="OMA" id="FSHNGAV"/>
    <dbReference type="OrthoDB" id="693464at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30102" checksum="DC673DBCFF9F0392" modified="2006-07-11" version="1">MCRLFGFRSAIPAAVHPSLVTEKNSLLIQSREHKDGWGIAAYGAEQAPVVAHGVGPAHSDPDFERVSSRVSSHTVVAHIRLASVGAVELRNSHPFLHGRWSFVHNGTLREFAQHRAAVEALICPSLRTNIRGTTDSERCFYLFLTRLHARHPIDRKVPVEAVARALAETMSLVAAITDAVGQDGRSAMNFLVSDGELMVASRRNRTLFVSTGPSRDDVSTLPAPGTKLEQLVVASESLCGGPYWAPVAEEDVIGVDANLVFHHWRVPELAGPDLFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4D1</accession>
    <name>Q1D4D1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554320.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4317"/>
    <dbReference type="EnsemblBacteria" id="ABF91567">
        <property type="protein sequence ID" value="ABF91567"/>
        <property type="gene ID" value="MXAN_4317"/>
    </dbReference>
    <dbReference type="GeneID" id="41361628"/>
    <dbReference type="KEGG" id="mxa:MXAN_4317"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_2_1_7"/>
    <dbReference type="OMA" id="WGIAGFC"/>
    <dbReference type="OrthoDB" id="1518604at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="15994" checksum="1FCF1FFA38485585" modified="2006-07-11" version="1">MRSSLSAFLSGLIFAIGLGLAGMTDPANVLGFLDIAGDWDYRLAFVMGGAIAVHAALRPLIHRRAQPLFATRFPAFAASKPDAKLLVGSALFGVGWGLAGYCPGPALTSLATGAFPLLVFVPAMFAGFYLAQVLQARSGVGAPRPGAPHVGATPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4M6</accession>
    <name>Q1D4M6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="13">PRA-CH</shortName>
                <ecNumber evidence="13">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="13">PRA-PH</shortName>
                <ecNumber evidence="13">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">hisI</name>
        <name evidence="13 15" type="synonym">hisIE</name>
        <name evidence="15" type="ORF">MXAN_4222</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="13"/>
    <dbReference type="EC" id="3.6.1.31" evidence="13"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554225.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4222"/>
    <dbReference type="EnsemblBacteria" id="ABF92454">
        <property type="protein sequence ID" value="ABF92454"/>
        <property type="gene ID" value="MXAN_4222"/>
    </dbReference>
    <dbReference type="GeneID" id="41361539"/>
    <dbReference type="KEGG" id="mxa:MXAN_4222"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_3_1_7"/>
    <dbReference type="OMA" id="ERSCFHQ"/>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="14">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="13">
        <location>
            <begin position="109"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF92454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="21648" checksum="A31D99DB453E50C6" modified="2006-07-11" version="1">MLDLDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGPWHKGATSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAPAERPDDAPPSYTRRLLEDRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVAVRPLGLSLDDVKAVLARRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S1</accession>
    <name>Q1D4S1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ABF87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554180.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4177"/>
    <dbReference type="EnsemblBacteria" id="ABF87070">
        <property type="protein sequence ID" value="ABF87070"/>
        <property type="gene ID" value="MXAN_4177"/>
    </dbReference>
    <dbReference type="GeneID" id="41361495"/>
    <dbReference type="KEGG" id="mxa:MXAN_4177"/>
    <dbReference type="HOGENOM" id="CLU_1179203_0_0_7"/>
    <dbReference type="OMA" id="MYAGIFL"/>
    <dbReference type="OrthoDB" id="1169201at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="250" mass="26969" checksum="24E5AB4FAC905B9A" modified="2006-07-11" version="1">MPEDERRTSLRDLHHHMTSLAQPARVFVDPLDGTRAAVEARRWVWPLLILALCVSASGTLFSLRWDVAPDVIRQLQGSGQLMGLSEADLTDKIQTESRKALVGGIAKGVILMPLMALLLACILWVVSWLFDRPASFEQLLSAAVLALLPIALYHLILTLCVAAQHSITMARVMNLVPSNLGAVLQGLSPKMQRVASTVDFFNLWSTGLLGLGFSAATGMSRGRAVLLAVALYAMYAGIFLIGLPAQAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U4</accession>
    <name>Q1D4U4_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4154"/>
    <dbReference type="EnsemblBacteria" id="ABF90795">
        <property type="protein sequence ID" value="ABF90795"/>
        <property type="gene ID" value="MXAN_4154"/>
    </dbReference>
    <dbReference type="GeneID" id="41361473"/>
    <dbReference type="KEGG" id="mxa:MXAN_4154"/>
    <dbReference type="eggNOG" id="COG1413">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914749_0_0_7"/>
    <dbReference type="OMA" id="AERQHPA"/>
    <dbReference type="OrthoDB" id="776087at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="33084" checksum="6FB459A96AED9240" modified="2006-07-11" version="1">MKPVLLLASCVVLMLGACRWQSPRYPVAPVELSGATLRDNALLGLDPEGVATLFTAALKDSGRFEQKGAEAPREERPWRMTLDVPFTREVLKDGDPRSFAEVGANLVLERFGGSLPQRYELVGLGEAPVEEDSPAGRQMAMRTALTNVLRQVTESAVMQLTALDRSDEALVLDLKATDSRVREFSLRTLAERQHPAAAPLLIDRLKEATDAETVRRTMGSLVEMKARVAVPVLIDLARGRDLGFVQEIVFAVGEIGGPEAEAYLYTMAQGHDAPAVQAAAQQALDTLYASRKHSPAEARGPGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4W5</accession>
    <name>Q1D4W5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4133"/>
    <dbReference type="EnsemblBacteria" id="ABF88084">
        <property type="protein sequence ID" value="ABF88084"/>
        <property type="gene ID" value="MXAN_4133"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4133"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725270_0_0_7"/>
    <dbReference type="OMA" id="WEVRAVM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="394" mass="42824" checksum="539DED392E8D8D6F" modified="2006-07-11" version="1">MAWRGRRHHLPPDMARVNPFSALLGSLDSSLEPSGYVPRGNAVPQPSHVRPLLEAANPTAELRRLRDSGALLRDTRPAMYLVEVQGPTGKLGGPPVRFLLCALNPDAGASLEHDPYRPRAWEAEPAVTLTADDHGVLRGLLAEASARAIVVWEGRYGQNTLSLRRIEPSPVSKRLQAVLDEAPMRPLAALHERSPTLAAVVPLSDPGLELLPIHRALKGVETFKEETFLTLVTAYARVYELDEPLNNPRGLAVARERLATLITGHHAVLLVLPGGRGRILRFRQGLDLAHLKGAPRNPTLRSLDLALLNALVLRTVLGIKDPEAPGHSQVYPVQGLESLVQGVESGMFQAGFALNPPPLWEVRAVMEAQATLPPSTLRVEPLPPAGLLYLDREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D552</accession>
    <name>Q1D552_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sigma-54 dependent DNA-binding reponse regulator Nla6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nla6</name>
        <name evidence="10" type="ORF">MXAN_4042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554050.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4042"/>
    <dbReference type="EnsemblBacteria" id="ABF90774">
        <property type="protein sequence ID" value="ABF90774"/>
        <property type="gene ID" value="MXAN_4042"/>
    </dbReference>
    <dbReference type="GeneID" id="41361373"/>
    <dbReference type="KEGG" id="mxa:MXAN_4042"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="HSNRCHG"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="484" mass="53584" checksum="D6A05D321E79652B" modified="2006-07-11" version="1">MGSARILAVDDERDTCEALADMLSAWGHKVEIAFDGHDALRKANEFRPDVVLSDLAMPETDGLWLLRNLKEELPDCPVVFLTGRGTIDAAVESIREGAYDFIVKPLDTARLKVCIDRALEKKETMREVQTLRRRLKQLGSSDLIAQSVGMRKVIELVEKVAPSKASVSISGESGTGKEVVSRAVHNLSLRRDKPFIAINCASIPATLIESELFGHERGAFTGADQRRPGVFEMAHGGTLFLDELGEIPIELQAKLLRVLEEGKLRRLGGKVEIEVDVRVLCATNRDLKQEIKNGRFREDLYFRLNVFQIHLPPLRERRDDVPILVQHFVDKFRGDSGKRVSGVHPEAMEVLKNYDWPGNIRELRNAVERAVILCDGELITREHLPPDMAGKSPERHTFRLPFGLSLDAVEREYILGSLQRNGNNKARTAEVLGVSEKTLYNKLNRYAAEARAQQAPGGGGGGPLGGQGSDGAMGAMGTNSFVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5M0</accession>
    <name>Q1D5M0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553883.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3873"/>
    <dbReference type="EnsemblBacteria" id="ABF91996">
        <property type="protein sequence ID" value="ABF91996"/>
        <property type="gene ID" value="MXAN_3873"/>
    </dbReference>
    <dbReference type="GeneID" id="41361206"/>
    <dbReference type="KEGG" id="mxa:MXAN_3873"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094965_0_0_7"/>
    <dbReference type="OMA" id="ASIDGFW"/>
    <dbReference type="OrthoDB" id="1738709at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="18359" checksum="84F281E4754F537F" modified="2006-07-11" version="1">MSRWVLGEFRSSERMVEAARALRASGFLRLDAHTPIPVEDVEAVLGLPPSRLPLLGLIAGVGGAVGAYVVQWFTQAIDWPLNVGGRPLHSGPAFIPITFESGVLASACALFMGVIVACGLPRVTHPFLGLEAFRSASIDGFWLAVAVDDAEGADAAQGALRRLGAEVVLAVEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D627</accession>
    <name>Q1D627_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553727.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3710"/>
    <dbReference type="EnsemblBacteria" id="ABF89524">
        <property type="protein sequence ID" value="ABF89524"/>
        <property type="gene ID" value="MXAN_3710"/>
    </dbReference>
    <dbReference type="GeneID" id="41361043"/>
    <dbReference type="KEGG" id="mxa:MXAN_3710"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398391_0_0_7"/>
    <dbReference type="OMA" id="HGAITPG"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="718" mass="77242" checksum="762572ED6C597743" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6M9</accession>
    <name>Q1D6M9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553530.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3500"/>
    <dbReference type="EnsemblBacteria" id="ABF90786">
        <property type="protein sequence ID" value="ABF90786"/>
        <property type="gene ID" value="MXAN_3500"/>
    </dbReference>
    <dbReference type="GeneID" id="41360845"/>
    <dbReference type="KEGG" id="mxa:MXAN_3500"/>
    <dbReference type="eggNOG" id="ENOG50319PF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041430_0_0_7"/>
    <dbReference type="OMA" id="PHIHAGN"/>
    <dbReference type="OrthoDB" id="1439036at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="28518" checksum="EAEF36430712CE6C" modified="2006-07-11" version="1">MPRRVQHMAQRLVGCLIAVVTVFAAAGCKERSDKPVAGLLAAGAPVLRAEGKQWRPIAVGSQLLGHDELKATGPAVLEFFGGGLRFLEKGDTLEVGEADEAKLHGVNLPSRHIVEGKLQEAPRPLRIIAARYTQVQVTPASAQQEDPYSSNGYFVAFFTPNGLSPNKTSDEPSRDGPRKPLPPPPHRPRVPHIHAGNLGEGGLVATVEDGFIVAETDDLATAVLLEGGDVPLGRTVRLMVPAGTEVVLRTQQGRKIEVEGPADVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z6</accession>
    <name>Q1D6Z6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553413.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3380"/>
    <dbReference type="ESTHER" id="myxxd-q1d6z6">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89985">
        <property type="protein sequence ID" value="ABF89985"/>
        <property type="gene ID" value="MXAN_3380"/>
    </dbReference>
    <dbReference type="GeneID" id="41360727"/>
    <dbReference type="KEGG" id="mxa:MXAN_3380"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_2_7"/>
    <dbReference type="OMA" id="FSHGYCL"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="313" mass="35401" checksum="BC336879E325AE1E" modified="2006-07-11" version="1">MSPGPRYFHQDRLRVPDGAQLYYQVQGDGLPGMVFCDGLGCDGFAWKYLAPYLVRNHRVLRWHYRGHGRSTVPEDRSRIGMLYTCDDLRRMLDAVGMERVVLFGHSMGVQVALEFQRRYAQRVCGLVLVCGSYGNPLDTFHDSTALKRAFPLIRRVVERYPEQSARIIHTVLRTELAVQLAITLEMNRERIARNDLAPYFDHLARMDPVVFVRTLESMAEHNAWDHLPHVDVPTLVVAGGQDKFTPGWISEEMADRIPGAELELIPEGTHTTPLEAPGRVEARVERFLRERLNVRTGAPSPTPTPVVSPPAGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D774</accession>
    <name>RL4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">MXAN_3300</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002633607.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D774"/>
    <dbReference type="SMR" id="Q1D774"/>
    <dbReference type="STRING" id="246197.MXAN_3300"/>
    <dbReference type="EnsemblBacteria" id="ABF90616">
        <property type="protein sequence ID" value="ABF90616"/>
        <property type="gene ID" value="MXAN_3300"/>
    </dbReference>
    <dbReference type="GeneID" id="41360653"/>
    <dbReference type="KEGG" id="mxa:MXAN_3300"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_7"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000052450" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="207" mass="22809" checksum="D022C2CC71B2C88A" modified="2006-07-11" version="1">MAKFDVVDLDLKKVSEIELSDDVFGTEPNAHLFYEVAKMQQINRRRGTVGVKNTSLVSGGGKKPWKQKGTGRARQGSIRASHWVGGGKAMAPKARDYFYRPPRKVRRGALKSALSLRAQEKTLIILDGFSLDAPKSKQAFEVLTKRLKLQNALVIDDKGNTNLHRSVRNLAKFDVLPPEGLNLEAVLRHSHLVLTSAAAKTLEGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D780</accession>
    <name>Q1D780_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ORF">MXAN_3294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.128" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553339.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3294"/>
    <dbReference type="EnsemblBacteria" id="ABF88171">
        <property type="protein sequence ID" value="ABF88171"/>
        <property type="gene ID" value="MXAN_3294"/>
    </dbReference>
    <dbReference type="GeneID" id="41360647"/>
    <dbReference type="KEGG" id="mxa:MXAN_3294"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_1_7"/>
    <dbReference type="OMA" id="GERYLNY"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="164" mass="18843" checksum="756DE1660D93EEB6" modified="2006-07-11" version="1">MRRMREESAPEARHGYTIRQMAAEDLSAVMLLEQASFKNPWSQDLLKRELQHEWSTILLVEEEREADGPELLGLAIFWIVHDEVHVLNVATAPKHRRRGVARAVMDEVLARGRAKRCTLATLEVRKSNEAALQLYRAFGFRPVGIRPNYYVDEGEDAVVMVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D786</accession>
    <name>Q1D786_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:15325"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553333.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3288"/>
    <dbReference type="EnsemblBacteria" id="ABF88384">
        <property type="protein sequence ID" value="ABF88384"/>
        <property type="gene ID" value="MXAN_3288"/>
    </dbReference>
    <dbReference type="GeneID" id="41360641"/>
    <dbReference type="KEGG" id="mxa:MXAN_3288"/>
    <dbReference type="eggNOG" id="COG2937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015407_0_0_7"/>
    <dbReference type="OMA" id="EVIYVPC"/>
    <dbReference type="OrthoDB" id="580383at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00612"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cellular anatomical entity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102420">
        <property type="term" value="F:sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="PTHR12563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="8">
        <location>
            <begin position="341"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF88384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="851" mass="95724" checksum="A7F9DEEBCDE078DE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7B9</accession>
    <name>Q1D7B9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3255"/>
    <dbReference type="EnsemblBacteria" id="ABF89924">
        <property type="protein sequence ID" value="ABF89924"/>
        <property type="gene ID" value="MXAN_3255"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_3255"/>
    <dbReference type="HOGENOM" id="CLU_2936767_0_0_7"/>
    <dbReference type="OMA" id="GGWGYVW"/>
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    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="62" mass="6743" checksum="F1B6073EB3DBE68F" modified="2006-07-11" version="1">MMTLSTQMLWILAAAPGQVGSGRIVGGWGYVWACYGITVAMLVLYAVSLWVRRPKAPTDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7G9</accession>
    <name>Q1D7G9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553250.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3203"/>
    <dbReference type="EnsemblBacteria" id="ABF88430">
        <property type="protein sequence ID" value="ABF88430"/>
        <property type="gene ID" value="MXAN_3203"/>
    </dbReference>
    <dbReference type="GeneID" id="41360557"/>
    <dbReference type="KEGG" id="mxa:MXAN_3203"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059369_0_0_7"/>
    <dbReference type="OMA" id="RHCELSP"/>
    <dbReference type="OrthoDB" id="961336at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="39608" checksum="EFF98F60522F0B4E" modified="2006-07-11" version="1">MFYGPVDSPPHMSQLLLSSLAVVCPNCDGYNSPRSAACVLCGQALGEPAAAPRPAATKPPLAVARPGTPPGSRPVAVSNFPGGKVAEPVVPPAPSAIPPGLRPSARTPPPTAAGLTVERPPQQRTPTAPPGIMARTGGASGPATTRPPPPVPDSAMPSRAGAATTAPRPAPPAASRFGLAVIAGSTRGQRYKLPVTGCVVGRQRGAILFADDAFVSPLHATFLVKDGALYVRDESSASGVFVTVGGTEALTPRTHFSAGQRLFRFTGRLEPQPPVTGRPAIYGAPVPLGQAVYGVEEMLVGGRAGRAVMTAAPLLTIGLAHCDLSFPGDEGLAGRHCELSPTPTGALLRDLSGGLGTYVRLASGVERPLRPGDRVRLGQHVLQVETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7P9</accession>
    <name>Q1D7P9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4 8">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">panE</name>
        <name evidence="11" type="ORF">MXAN_3121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553171.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3121"/>
    <dbReference type="EnsemblBacteria" id="ABF89512">
        <property type="protein sequence ID" value="ABF89512"/>
        <property type="gene ID" value="MXAN_3121"/>
    </dbReference>
    <dbReference type="GeneID" id="41360482"/>
    <dbReference type="KEGG" id="mxa:MXAN_3121"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_6_1_7"/>
    <dbReference type="OMA" id="GMFSRGD"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="10">
        <location>
            <begin position="190"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="318" mass="33237" checksum="C0DC0C7307733C57" modified="2006-07-11" version="1">MRFAILGSGGVGGFFGAKLVRAGHDVTFLARGAHLRAMREHGLTIHGAEGDFTVAVKADDDVQRFGPVDVVVLAVKNYDVASVLPAVKTLLSARGAPAPGETPPFVLTLQNGVDSPSEVAAAVGEAAVLGGTTYISTAISEPGVITQTGTNHRIVLGEVFGDTSRISDRAQSLRDALAGAGITVEAVADARGALWDKLSFLACMSAFSTASRLPVGALRDNPAFREVFRQAAAEVLSVAAAEGITTTRTPDALVQYMDGLPAHMRPSMLGDLENGKPLEVEYLQGSVVRRGRARGVPTPVMSTLYVLLQPHAQGERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7Q7</accession>
    <name>Q1D7Q7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3113"/>
    <dbReference type="EnsemblBacteria" id="ABF92804">
        <property type="protein sequence ID" value="ABF92804"/>
        <property type="gene ID" value="MXAN_3113"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3113"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133767_0_0_7"/>
    <dbReference type="OMA" id="QWDATRR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="142" mass="15305" checksum="828939ACBC917DB6" modified="2006-07-11" version="1">MEAAPAPAMDDAALLRGLLGAVRPAPEEIRAIAIEDLALLGDARALDALATLLWDPNPRIQQAALRAVTLFQHARAEEILANVVRHPRLPDALKIQALNGLVFQRTPTARRAVQDAAVDSRLTAGVQNAARAVVTQWDATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7U0</accession>
    <name>Q1D7U0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553130.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3080"/>
    <dbReference type="EnsemblBacteria" id="ABF87259">
        <property type="protein sequence ID" value="ABF87259"/>
        <property type="gene ID" value="MXAN_3080"/>
    </dbReference>
    <dbReference type="GeneID" id="41360442"/>
    <dbReference type="KEGG" id="mxa:MXAN_3080"/>
    <dbReference type="HOGENOM" id="CLU_2107534_0_0_7"/>
    <dbReference type="OMA" id="WSQDEVK"/>
    <dbReference type="OrthoDB" id="1828342at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008769">
        <property type="entry name" value="PhaF_PhaI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05597">
        <property type="entry name" value="Phasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="13499" checksum="20DBB5D9C94E5645" modified="2006-07-11" version="1">MDNKPEAPREKHSVTETFERLWSQALLAVNTAEEEASRAVQRVAAVAGWSQDEVKRQAREFSERLAGHRKDLEHNVEERVRQTLTKMKLPRREELAAFGTRLDKLAERIQALEHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D846</accession>
    <name>Q1D846_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553024.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2968"/>
    <dbReference type="EnsemblBacteria" id="ABF88628">
        <property type="protein sequence ID" value="ABF88628"/>
        <property type="gene ID" value="MXAN_2968"/>
    </dbReference>
    <dbReference type="GeneID" id="41360331"/>
    <dbReference type="KEGG" id="mxa:MXAN_2968"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_7"/>
    <dbReference type="OMA" id="KTQVWVI"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188248" evidence="2">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="62"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="373" mass="38685" checksum="41B3AFE515E98FDA" modified="2006-07-11" version="1">MTGRSRTTVIRRMWMAAAVAAVVTTGCGKASNKPALPEQTGPAALGVRAITPATELSADVTRVTGQIRSKNEAVLGPQATGTISRMNVRVGDKVKKGQVLAALDASNVAISVEQARAVKQAADAALELATSSLERTRKVAESGGVAAAGLDQAVIGQKQAAAQAAQAAAGLRLAEEMLRDHSIIAPFDGVITARTKNVGDSVAMTPSTPVFSIVDTTGLEVRAQVPESVVDKVRVGSKTQGTVSPSGARFDVQVAVVGAVVDASNRTVEVLADVVGEPSPALRPGALVELDFSTVNQADDDKGLFLPTQAVSARGQEGFVWVVQDGTVRKRDVRVERVLPGYVRILQGLGADERVLADSSLDVKEGTAVRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8C0</accession>
    <name>Q1D8C0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552953.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2892"/>
    <dbReference type="EnsemblBacteria" id="ABF86084">
        <property type="protein sequence ID" value="ABF86084"/>
        <property type="gene ID" value="MXAN_2892"/>
    </dbReference>
    <dbReference type="GeneID" id="41360261"/>
    <dbReference type="KEGG" id="mxa:MXAN_2892"/>
    <dbReference type="eggNOG" id="COG3831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049015_0_0_7"/>
    <dbReference type="OMA" id="PRYEFKE"/>
    <dbReference type="OrthoDB" id="509083at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014338">
        <property type="entry name" value="CHP02996_rpt-companion-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="SSF142921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02996">
        <property type="entry name" value="rpt_mate_G_obs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WGR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="451" mass="49267" checksum="E05147AA05F9C897" modified="2006-07-11" version="1">MPRYEFKEGSSSKFWEINLSGSSFTARWGRIGTDGQEKTQTFGSPAEAQKEHDKLVREKEKKGYVLADKSDDDDSEGGGGEEPASNPELEAAILKDPDNVDAYLVYSDWLQGQGDPRGELIAIQHAASQASGTEASDLKRKATAHIKKYQTLLLGELAAGVKSEELSLEWHLGFIRSARVGQKEYDSDFNVPEMAGALLKHPSARFIRGLTIGMASFDGENEYGETVQALVEAGGSKTIQELFIGDFEYPDDTEISWTHLTDISALLKVLPDLRKLRLRGGELELGAIDLPELREFTVETGGLPLAAVKSIANAKWPKLERLEVWFGSDNYGAEGGVEDIQPILDGKGLPNLKQLGLRNSEFTDALAQALPTAKVLPQLETLDISMGTLSDEGARALADKAAAFAHLKQLDVTENTLTDEGQSLLPKAIPHANVGNQRDYEEEYRYSAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K3</accession>
    <name>Q1D8K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552870.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2803"/>
    <dbReference type="EnsemblBacteria" id="ABF91216">
        <property type="protein sequence ID" value="ABF91216"/>
        <property type="gene ID" value="MXAN_2803"/>
    </dbReference>
    <dbReference type="GeneID" id="41360179"/>
    <dbReference type="KEGG" id="mxa:MXAN_2803"/>
    <dbReference type="eggNOG" id="COG3332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047037_1_1_7"/>
    <dbReference type="OMA" id="CTLTLAW"/>
    <dbReference type="OrthoDB" id="1721287at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="PTHR17985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="28996" checksum="F1B684432E2583BB" modified="2006-07-11" version="1">MCTIIILRHIHPEWPLVLAANRDEFYARPATGPQVLLESPLAVGGRDEERGGTWMGVTHGGLFVGLTNQRGERGQGPAPRSRGEVVLKALQAGSVDAVDRYLDSLPGDEFMPFNLLYGDAQRLRVAYARRTDRQLRREDVPPGVHVLPNDVLNAPELPKVERARLLTTEVAKKPWPELAEGLKAVLADPTLPTEELIPPPGAGEDLPRDFLQRLQALCIHTPLYGTRSSAVVALAPGRVGHYLASDTPPCQGPWKDVTGLLTGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R6</accession>
    <name>Q1D8R6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC/Ohr family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552807.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2740"/>
    <dbReference type="EnsemblBacteria" id="ABF90374">
        <property type="protein sequence ID" value="ABF90374"/>
        <property type="gene ID" value="MXAN_2740"/>
    </dbReference>
    <dbReference type="GeneID" id="41360118"/>
    <dbReference type="KEGG" id="mxa:MXAN_2740"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_5_0_7"/>
    <dbReference type="OMA" id="CMLTVMG"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="15260" checksum="983F921DEBC80155" modified="2006-07-11" version="1">MSPPQTPATGVVMTLVSQPQFKTQLTHGPSGTVNQTEAPRDNGGTGGSFSPTDLVGAALMSCAVTTMHLFASREGIALGEVSARVEKRMSPPPRRIAELVLDIQMPAGLSAEHRATLEKVGRECPVARSLHPDVKLPLTFSYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Y9</accession>
    <name>Q1D8Y9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552735.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2665"/>
    <dbReference type="EnsemblBacteria" id="ABF90148">
        <property type="protein sequence ID" value="ABF90148"/>
        <property type="gene ID" value="MXAN_2665"/>
    </dbReference>
    <dbReference type="GeneID" id="41360041"/>
    <dbReference type="KEGG" id="mxa:MXAN_2665"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097105_0_0_7"/>
    <dbReference type="OMA" id="FWAERFF"/>
    <dbReference type="OrthoDB" id="1427697at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="248" mass="27915" checksum="93346B06F37B86D2" modified="2006-07-11" version="1">MAYDDFKKRIRDDWRDTLRSILERARSQGSSAVLAFDLDSTLFDNRPRQARILREYGAARSLAVLAACEPHHWVTGWDMKEAMRACGLEDALVESHFAEARRFWAERFFTSDYCVDDEAIDGAASFTHEVVATGARLVYVTGRHEAMREGSVSCMRRHGLVLPDDDRVLLVMKPTLAEDDDAFKREAHARLGRLGSVVAAFDNEPTHANDYRRKFPEATVIHLATDHSGRPVELLDGVISVPHFALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Z1</accession>
    <name>Q1D8Z1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol 3-phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glp</name>
        <name evidence="8" type="ORF">MXAN_2663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552733.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2663"/>
    <dbReference type="EnsemblBacteria" id="ABF86840">
        <property type="protein sequence ID" value="ABF86840"/>
        <property type="gene ID" value="MXAN_2663"/>
    </dbReference>
    <dbReference type="GeneID" id="41360039"/>
    <dbReference type="KEGG" id="mxa:MXAN_2663"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559995_0_0_7"/>
    <dbReference type="OMA" id="WEPFDKS"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="487" mass="51771" checksum="DD4CB63DED49395E" modified="2006-07-11" version="1">MSSLPPWLAQFLPILILLGAIGLVLTRLPKVELGHSEAFKRRRFFNWFPLGMTYAFLYMGRYNLNVATSAMGDRTSNADFGTIFAWGTAVYGVAFLLNGPLTDKLGGRKTILMAAAGSAVANVAMGGVVYAVLTHNWAPPGGLVATLSFLYAVNMYFQSFGAVSIVKVNAAWFHVRERGLLGGVFGILISLGIYFAYDWSRLIVKAAPTYWAFFVPAAILAVFLVVDYFVIRDTPSHAGHPDFDTADASSGETGPQLGVAGVLKRMLTNRAIIIILCIEFCSGFMRNAIMQWYPKFAKATGLGETFVAANWGMLLCVAGITGGMFAGVISDRVFDSRRGPVSAVLYAGMSVGAVISVFVLESVALGWTVIFMSLCVIGVHGMLSGTASMDFGGKKNAGLAVGIIDGAVYAGTALQSILLGSILPMGDEAKTAANWGNWPYAMLPLSFLGLLLATQVWNARPQPKSTPVPATLPVPSEAPANRTGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9C3</accession>
    <name>Q1D9C3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552601.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2531"/>
    <dbReference type="EnsemblBacteria" id="ABF88913">
        <property type="protein sequence ID" value="ABF88913"/>
        <property type="gene ID" value="MXAN_2531"/>
    </dbReference>
    <dbReference type="GeneID" id="41359909"/>
    <dbReference type="KEGG" id="mxa:MXAN_2531"/>
    <dbReference type="eggNOG" id="ENOG5030GNT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668739_0_0_7"/>
    <dbReference type="OMA" id="QCGQSLA"/>
    <dbReference type="OrthoDB" id="1230195at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="44914" checksum="39DA562540C819A1" modified="2006-07-11" version="1">MRERNSSCPAYIRGESMNATLLQLHHREAFEQTVTRALTAGAGAGVLHLAMTRVGVPLPLAWLVPAAVVLGCARGDKWDRVLLGGLGVLLTALPYALGMAPGWTVAFSAAAAGALLVRSRLSERGENGQVAEARPTLFHFGLGAALCAGLTLGGMEVSRVFSARLADLATPALLGAGVAGGILGLFVGLSAVAAHLALSADPVEARVEALLPQLAGDFHALTERALNLYRQCGQSLAMLPREPAREELARTLGKMTRDAAELASEWAGVEAQIEERAQADLQAEREDLERSARASTDAIARRQLELAAASLGEEVERLGGLKQRRERILARLRAEVAQLERARVALLSLRSGQAQLKAAELSALARRFRALSSLQREEAQSMEDVSSMIQGASMHSSPLEVRQAEGEESPASGPASEQPRVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D3</accession>
    <name>Q1D9D3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552592.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2521"/>
    <dbReference type="EnsemblBacteria" id="ABF87997">
        <property type="protein sequence ID" value="ABF87997"/>
        <property type="gene ID" value="MXAN_2521"/>
    </dbReference>
    <dbReference type="GeneID" id="41359898"/>
    <dbReference type="KEGG" id="mxa:MXAN_2521"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043936_0_0_7"/>
    <dbReference type="OMA" id="TAYHACA"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="173"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="303"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="449" mass="48901" checksum="B3328836D48EAD4E" modified="2006-07-11" version="1">MPGRKGMNESSLRELGMDLIEERQFERALAVFAEAVRRVPADHRSRMLAARCLAELGERERAVTAYHACAEGLLRRDYLLSAMAACKLALDLAPNERRLKETLFRVHSRAVRNAPGRAVVPPPLPPETLYDGKVETDLMGLQGEELSSRAIEVLAATDPGGAADPNSRPPLPLFAELDRDAFVDLVRLMAWRRVKPEEAVSREGEPADSLYVLVAGKAEVTRQMEGEARTLGFLGGGSIFGEIALLTGAPPTATVSAVSDTEVFEIRREHLNAVAKSHPAVPQVLADFAQQRMARNLMATSPMFQTMPESERGALLRRFTFRALQAREKVLVEGEHSPGLFLVLAGELVVQKEDPAGGVVTLGMLREGEVAGEISLLTGLRATATVAAARKTAAAFLERAAFHELVTAVPDIRTYLEQLSDRRLKQIGEALRPAEIIDADELVLEPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9D6</accession>
    <name>Q1D9D6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PmbA/tldD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552589.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2518"/>
    <dbReference type="EnsemblBacteria" id="ABF92013">
        <property type="protein sequence ID" value="ABF92013"/>
        <property type="gene ID" value="MXAN_2518"/>
    </dbReference>
    <dbReference type="GeneID" id="41359895"/>
    <dbReference type="KEGG" id="mxa:MXAN_2518"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_0_0_7"/>
    <dbReference type="OMA" id="LYRKSTF"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="119"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="230"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="47917" checksum="A92C9EDA9C52B915" modified="2006-07-11" version="1">MDYQQLAKRIVQRAKRKGARQAEAFLEVGRQSSVRVHQGQIEDLTQSTSKGVGVRVVLKDRLGFAYTSDFEPSAVDHIVDQALKLAEFSAPSKLNGLPSGKDLGRFGDTGLLFDTKVAELPGDWKIKTALEVEKAARAEDSRIIAFNGVGAGDYVSEVYMASTEGVTGAYSGTYVYLYAAPVASDGNGLQTGYWMDYRRFLDDLDGPESIGREATRRAVRMLGAKRVKTQQVPVLFDPQVAASFVSDVAGAADGNAVYQKASLLASLLGKRLAGAHVTLVDDGLMPRGLATAPFDGEGVPTRRTPIIEQGVLKSFLYDAFTARKAKARTTGNASRSYNGLPSIGTSNLYLEAGTKSPEELLREVDSGFYVTALLGHGTDPVTGELSAGANGLWIEKGELTHPVQEVTVAGSLLQMLKDLDGVGSDLQFRSGAVGAPTVRFRQLTVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H7</accession>
    <name>Q1D9H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552548.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2476"/>
    <dbReference type="EnsemblBacteria" id="ABF92607">
        <property type="protein sequence ID" value="ABF92607"/>
        <property type="gene ID" value="MXAN_2476"/>
    </dbReference>
    <dbReference type="GeneID" id="41359859"/>
    <dbReference type="KEGG" id="mxa:MXAN_2476"/>
    <dbReference type="eggNOG" id="ENOG5030URA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643767_0_0_7"/>
    <dbReference type="OMA" id="ADNAQFW"/>
    <dbReference type="OrthoDB" id="519709at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="46380" checksum="996BC5216189D3BC" modified="2006-07-11" version="1">MRDRFPLLVVGGLLLTAVLTTFLVRGARRNTFADTLSTYRAQEDGARALFLLAQESGLPVTRRMADLRIVSGLGTPVLLAVEVSGAYEDDPDQTALAAEPDAGLADEHVPRTGFNAFRAAALDDDETEQLLKHVREGGSAIYVPWGSRENPVLQALNVKLFKADTTLPMRTLVPPQPTPYTLGVERVEAKVQAYLELPQMAVPVLEDERLGMFVAAVVPYGQGRVLVVGAPELAMNQALARADNAQFWLSALASIGPGPIEFDEFHHGFTNERSVVDFARRYGLHFAVLQFLLGVALWSVSLKRFGRPRPPPESSRVGATDALFAMGRLYREGRHHGFSAQLILRGLTQDLALHAGLPAHASADAVTHGLRERGRADLAQGLEELTTDSRAVTRDTDLQQLAERAARLRQRLHSAGAARPSPPETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9K5</accession>
    <name>Q1D9K5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliQ</name>
        <name evidence="10" type="ORF">MXAN_2448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002637061.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2448"/>
    <dbReference type="EnsemblBacteria" id="ABF86537">
        <property type="protein sequence ID" value="ABF86537"/>
        <property type="gene ID" value="MXAN_2448"/>
    </dbReference>
    <dbReference type="GeneID" id="41359832"/>
    <dbReference type="KEGG" id="mxa:MXAN_2448"/>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164516_1_1_7"/>
    <dbReference type="OMA" id="MVQAATS"/>
    <dbReference type="OrthoDB" id="1939288at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006306">
        <property type="entry name" value="T3SS_HrpO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01403">
        <property type="entry name" value="fliQ_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF86537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="87" mass="9579" checksum="CCCBDC546419A6D7" modified="2006-07-11" version="1">MNQLTFITQEALFLVLVASAPPVLMSLLVGFIISLFQATTQIQEQTLTFAPKVVAVFGVLALAGPWIGSQLVRFTFHVFDRFPALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA31</accession>
    <name>Q1DA31_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2271"/>
    <dbReference type="EnsemblBacteria" id="ABF86720">
        <property type="protein sequence ID" value="ABF86720"/>
        <property type="gene ID" value="MXAN_2271"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2271"/>
    <dbReference type="eggNOG" id="ENOG50346GS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1683609_0_0_7"/>
    <dbReference type="OMA" id="AWTETSG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="179" mass="19993" checksum="7D94D17270B9CEA7" modified="2006-07-11" version="1">MRVGSGGNGRTPLLGADVLQGAAVFRFENDRALIESFRPRDRRVIEMPPGITFPLFVRDYLAWTETSGARVYLIFSAPGSRKPIGIIFRRDALGGEPVTRMCEWCHSYGSAHEVCLLTTAVDNKRRVGVNLCADLRCREKMEDAADRSGRHPLEFLGKLNERMFRFAHEALGIEAQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA59</accession>
    <name>Q1DA59_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552319.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2243"/>
    <dbReference type="EnsemblBacteria" id="ABF89894">
        <property type="protein sequence ID" value="ABF89894"/>
        <property type="gene ID" value="MXAN_2243"/>
    </dbReference>
    <dbReference type="GeneID" id="41359631"/>
    <dbReference type="KEGG" id="mxa:MXAN_2243"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049749_4_0_7"/>
    <dbReference type="OMA" id="KERPMIF"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="27310" checksum="453211286A5075A2" modified="2006-07-11" version="1">MAQNIYDDPGFFEGYSQLRRSMEGLAGAPEWPALRAMLPELRGLRVMDLGCGYGWFCRWAREQGALQVHGLDVSARMLERARQLTSTRDIVYTQADLETVELPRASFDLVYSSLAFHYIEDLPSLLAKVHATLVPGGALVFSTEHPIYMAPTHPGWRVDEQGQKTWPLNGYQAEGPRTTDWLAKGVLKYHRTLGTLLNALIHTGFSLRQVNEWGPTEAQLSAQPELAEERERPMMLLVSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY3</accession>
    <name>Q1DAY3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ORF">MXAN_1952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1952"/>
    <dbReference type="EnsemblBacteria" id="ABF92988">
        <property type="protein sequence ID" value="ABF92988"/>
        <property type="gene ID" value="MXAN_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1952"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_7"/>
    <dbReference type="OMA" id="HEEFWII"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="101"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="241" mass="25616" checksum="C271C4593FD3D267" modified="2006-07-11" version="1">MRARGVGGAEESRERLFRLGAAALTDPELLCVVWSSGPRAPGAWAVAGALLSEGGGLKGLVQQEPLALSLRPGVGPVRAAQALAALELGRRSQRARERRPRLRTPKEIAAYLAPVLGALRREVFHVLCFNARNVLVHDARVAEGTMNTCPVDPREVFAAALTSRATSIVLAHNHPSGDPEPSVQDLGLTRHLVAGAQLLNIKVLDHVVMGDGGYVSMLERGLMPDEAQEKRRAWSANGGGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAZ4</accession>
    <name>SYS_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">MXAN_1941</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552034.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DAZ4"/>
    <dbReference type="SMR" id="Q1DAZ4"/>
    <dbReference type="STRING" id="246197.MXAN_1941"/>
    <dbReference type="PRIDE" id="Q1DAZ4"/>
    <dbReference type="EnsemblBacteria" id="ABF86369">
        <property type="protein sequence ID" value="ABF86369"/>
        <property type="gene ID" value="MXAN_1941"/>
    </dbReference>
    <dbReference type="GeneID" id="41359354"/>
    <dbReference type="KEGG" id="mxa:MXAN_1941"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_7"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000019745" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="426" mass="47838" checksum="25BC046649BC5213" modified="2006-07-11" version="1">MLDLRNVAQNFDAVVARLKTRGGNLDLGPFQRLFAERRELYVSVESLAARRNAANEEMKRKAKEDPKALDALRGDLRAVSQEIKEKEARLKDVEEELNRILLLIPNVPHESVPEGGGAEDNVQVSIWGQKPDLLFAPKQHFELGEKLGMLDFERAAKVSGSRFTFYKGALARLERALVTFMIDVHTSKGYTELLPPYLVLRETMMGTGQLPKFEDDAFKTLGEPERFLIPTAEVPVTNYHADEILEGESLPIRYCAFSPSFRAEAGAAGKDTRGLIRQHQFHKVELVKFAHQEKSLDELEAMTDDACDILRRLGIHHRVMLLCTGDMGFAARKTYDIEVWLPGQNSYREISSCSDCGDFQARRAKIRYRAQRGDKPQLAHTLNGSGLAVGRTTIAILENYQREDGSVAIPEALVPYMGGLKELKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB20</accession>
    <name>Q1DB20_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase, RsmB/NOP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552009.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1909"/>
    <dbReference type="EnsemblBacteria" id="ABF92880">
        <property type="protein sequence ID" value="ABF92880"/>
        <property type="gene ID" value="MXAN_1909"/>
    </dbReference>
    <dbReference type="GeneID" id="41359323"/>
    <dbReference type="KEGG" id="mxa:MXAN_1909"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_2_7"/>
    <dbReference type="OMA" id="GWFEQQD"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="157"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="427" mass="46335" checksum="FCF9223E80E02B10" modified="2006-07-11" version="1">MVPALSTVPFDPLSRLHLQPWSALAGLGPVAADAIAQVLAGSAAERVLDRTLRDRRSLTREQRLALKEAVFNVGLWRRRLGFLLGREDAAPLFLLHALMHGLAGVPAVESAALAGLGDGAPPPLVSAPPPTLALRASLPDWLADHFAREFGPEADDFCAHLNVPGPITLRANVLRTSREALAERLRSEGVETRPGPWSPLALHIEGPRPNLYGLRSLQEGLFEVQDEGSQLLGLLVEARPGETVLDLCAGAGGKTLQLGADMKDSGRLLAYDPDPERLDRLLQRSSRAHLTRVQVLRSLPESLDADRVLVDAPCSELGSLRRGPDQRFRIQPEVLTRFPALQQDILQRGARLVRPGGRLVYATCTVNRAENEDVVAAFLASRPDFRLVRPGAGWLSDACLRDGFLFVAPHRHGTDAFFAAVLERTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB78</accession>
    <name>Q1DB78_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551951.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1849"/>
    <dbReference type="EnsemblBacteria" id="ABF89198">
        <property type="protein sequence ID" value="ABF89198"/>
        <property type="gene ID" value="MXAN_1849"/>
    </dbReference>
    <dbReference type="GeneID" id="41359266"/>
    <dbReference type="KEGG" id="mxa:MXAN_1849"/>
    <dbReference type="HOGENOM" id="CLU_2881173_0_0_7"/>
    <dbReference type="OMA" id="ERMGQQR"/>
    <dbReference type="OrthoDB" id="2038287at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="63" mass="7160" checksum="19C41C594198A4A8" modified="2006-07-11" version="1">MTLETWREGLFQLCWHQHGGSGLAAPLGDALELPTSDRDWLLERMGQQRAQEAKALEKAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBB4</accession>
    <name>Q1DBB4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4150 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551918.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1813"/>
    <dbReference type="EnsemblBacteria" id="ABF89517">
        <property type="protein sequence ID" value="ABF89517"/>
        <property type="gene ID" value="MXAN_1813"/>
    </dbReference>
    <dbReference type="GeneID" id="41359230"/>
    <dbReference type="KEGG" id="mxa:MXAN_1813"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620969_0_0_7"/>
    <dbReference type="OMA" id="YCKTICK"/>
    <dbReference type="OrthoDB" id="1068689at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025425">
        <property type="entry name" value="Tox_PAAR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13665">
        <property type="entry name" value="DUF4150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4150" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="417" mass="44816" checksum="58BBAFA78288A178" modified="2006-07-11" version="1">MAKVTVNFPRTPVTKGSSGIAAATLPNVCKMPGPPAPFVPTPLPNIGNSGDAPEGYSKTVTINGHPVAIAGASFGSKGDMASKGTGGGLISSNTHGPTKFIGPGSMNVKIEGRNVQLLGDPMLNNCGPSGSPANAATMTGIIQASGVMTVIYGDDIPCSRCGKEHPLGAGEATQKAIATLFKRLQAALDKQKQQILEYAELDKEEYTKRSALAQLKKLNTPERRTAGKGLRPEQRAELERLPGELAALRAKLAPLRDFFKNKAVLRYTPNTNSYTKGYMIGAMVCTCATKKLVACSGHAPPGFWPAVKAAEFECVNSRVGAGAREEKWMCAAKQIMENHGGHKPKHLAERLFYPIVEGIKLERGPKIKFKIREEDINTKKLSEPKEREQVFKHGEDVPSCSECQEKLPAMYCKTICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBC4</accession>
    <name>Q1DBC4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87933">
        <property type="protein sequence ID" value="ABF87933"/>
        <property type="gene ID" value="MXAN_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1803"/>
    <dbReference type="HOGENOM" id="CLU_2974663_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="58" mass="6464" checksum="4E2DB21A20584EDB" modified="2006-07-11" version="1">MWSPVGEGFSCMVTRIGRRLPLLIHTGHGEQILLSTLLARCAKLPRFNVEEQMPMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD7</accession>
    <name>Q1DBD7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HlyD family secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551895.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1788"/>
    <dbReference type="EnsemblBacteria" id="ABF87986">
        <property type="protein sequence ID" value="ABF87986"/>
        <property type="gene ID" value="MXAN_1788"/>
    </dbReference>
    <dbReference type="GeneID" id="41359209"/>
    <dbReference type="KEGG" id="mxa:MXAN_1788"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037316_0_0_7"/>
    <dbReference type="OMA" id="HNAVHRI"/>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="44731" checksum="428F61508122B04B" modified="2006-07-11" version="1">MAYPFERTLRSLNYESDTRLVFVALMVLCAGGLIAWSLFAKVPLVKASSQARIEPHNAVHRIEPPSAGRVVLSLLKLDQEVKEGDLLIEFDARAERLELERSNATLAATEKELAIIRQQITNKHEEAALTARVDEVAVKEALGREQELAPRHRLAVERAELAFKSPAGAVSEMEKLERTTDVDALRFAQTAQGLALIRLRREQNVRRQALAAQLLELEREALGAEGRIRELQGTIDRLEYQIERKLYRAPATGHLVDVAELGSGAFIADGQRVGTIVASNAEVRVRARFPKEVVGLIQPGQTARLKLDGYPMTIYGTVPARVTAVGTEPGQTATPEAIPGTVRVELKFAPPDDPRIQLRHGMTLSVEVEVARASPVALLMRAVGEWNPQPEERPTNVFRPEAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE5</accession>
    <name>Q1DBE5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91898">
        <property type="protein sequence ID" value="ABF91898"/>
        <property type="gene ID" value="MXAN_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1780"/>
    <dbReference type="HOGENOM" id="CLU_2494670_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="8984" checksum="1A30B30BC2ADDF34" modified="2006-07-11" version="1">MHETFCVSVNDASVETVKLNGVEPQSLPQWMCSTPSWTASASFCPTHGSESSMGPGALRTYAAHATDSARLHASADSPSGLARTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBZ6</accession>
    <name>Q1DBZ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551686.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1575"/>
    <dbReference type="EnsemblBacteria" id="ABF91140">
        <property type="protein sequence ID" value="ABF91140"/>
        <property type="gene ID" value="MXAN_1575"/>
    </dbReference>
    <dbReference type="GeneID" id="41359020"/>
    <dbReference type="KEGG" id="mxa:MXAN_1575"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_7"/>
    <dbReference type="OMA" id="DLQCEAV"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="311" mass="33277" checksum="429177019180585B" modified="2006-07-11" version="1">MTSEQLRAFLEVARAGRLATAARGLGLSQSGLSRQLQSLEAALGTRLLVRTPGGTVLTDAGERFLPHAQRALDALTAGTSELERLSGTPHGVVSLGTLHTVGAYLLPDIIPAFARQFPEVRPRLSEGLAPAMEEGVARGALDLAILSLPVRRADLVAQRLWEESLVLAVPRGHRLTKSGKPVTMDEAVEEPWVVIPGMSGTRAMEAACEARGVTPRLAVETDNAEAMRRMVERGLGVAMVPQLMARDHHAQGFDVVPLARAGVKRQVALIHRGEGYLTAAARALKSFIVESVRAMPEPWGTRKAAPGARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC4</accession>
    <name>Q1DCC4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551558.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1442"/>
    <dbReference type="EnsemblBacteria" id="ABF89662">
        <property type="protein sequence ID" value="ABF89662"/>
        <property type="gene ID" value="MXAN_1442"/>
    </dbReference>
    <dbReference type="GeneID" id="41358888"/>
    <dbReference type="KEGG" id="mxa:MXAN_1442"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_7"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="12"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="461" mass="50219" checksum="6C7BD0B8780336D9" modified="2006-07-11" version="1">MSPKSKREDLPHVVILGGGFAGLYAARHLYRAPVRVTMVDRQNHHLFQPLLYQVATATLSPSEIAAPLRAVLGHHQVAVVLAEVTGVDTAGKRVLLSDGELNYDYLVIATGATHSYFGNDAWAQFAPGLKSIEDALAIRRRILVAFELAERETDPEIRRSLLNFVIIGAGPTGVELAGSLAEISRHSLHGDFRNFDPRDARIILIEGMDKVLPVYPDDLSQKACRTLEKLGVEVRTGARVTNITEQGVFIGQEFIPARTVLWAAGVAASPVAKSLGVELDRSGRVLVTPELTIPGHDDVFVVGDLSLLKDAEGKPVPGLAPVAMQEGKHAAHNIRRQLQGKPMVPFSYWDRGSYAVIGRGHAVGIAFRRFKQAGFGAWMAWLLIHITFLIGFRSRLAVLLNWAFSYLTFGKSARIITGPSPRLDRLQPTHALPEGGQTPSIAEPRFQTTTSHAESATTGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCG8</accession>
    <name>Q1DCG8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1398"/>
    <dbReference type="EnsemblBacteria" id="ABF89842">
        <property type="protein sequence ID" value="ABF89842"/>
        <property type="gene ID" value="MXAN_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1398"/>
    <dbReference type="HOGENOM" id="CLU_1459824_0_0_7"/>
    <dbReference type="OMA" id="VHVMSLY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="224" mass="24434" checksum="5E28744AD0AB8E3E" modified="2006-07-11" version="1">MRLRGCPVFRVNLARGRKQTAPGTWGTLVNDMSDGNQKTVRPSHVRRTYILDRPFQLKYILLLAGIGAGSILVFGLLAHRVHVSSTALGLDGGQTLLWLTAVGALGTAVAMGLFGLVFTHRVAGPVHVMSLYVAALAAGRYPRMRPLRRGDELKQFFDRFTEAVTRIREREADEAYALETVLEALRPVATTPEALEALGTLSALHTRKRQAVDTPTGSTFKSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI4</accession>
    <name>Q1DCI4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551499.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1382"/>
    <dbReference type="EnsemblBacteria" id="ABF90155">
        <property type="protein sequence ID" value="ABF90155"/>
        <property type="gene ID" value="MXAN_1382"/>
    </dbReference>
    <dbReference type="GeneID" id="41358829"/>
    <dbReference type="KEGG" id="mxa:MXAN_1382"/>
    <dbReference type="eggNOG" id="COG1099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061552_1_0_7"/>
    <dbReference type="OMA" id="WAAFTIY"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="28803" checksum="52D7BD2118666D5E" modified="2006-07-11" version="1">MPTPPPIFDAHLHPESLSDQDLESMRFFGVERALVVAHHFPEPTSKALLRHFDDLVERQLPRLERLGIRAYAALGVHPRCIPRRGLSEVLSALPDYFQGGRVVALGETGLHTGGEEEEEAFLEQLALARSLKLRVVVHTPTTDKERHTRRILTLLRQSGLLPSRALVDHANARTVRTILEVGHWAGLTLHPEALKAERAVVLVRRLGSERLMLNSDAGDGAGDILGLARAANLLTKANLSARIVRRVTHENAARFFQVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI7</accession>
    <name>Q1DCI7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1379"/>
    <dbReference type="EnsemblBacteria" id="ABF85980">
        <property type="protein sequence ID" value="ABF85980"/>
        <property type="gene ID" value="MXAN_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1379"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_0_0_7"/>
    <dbReference type="OMA" id="GSDFPNI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="32228" checksum="1B6984EAF6BA296C" modified="2006-07-11" version="1">MPALQDTEGPRLPEGLPPVVDAHVHLFPDRVFDAVWRWFDQYGWPIRYKLHTRQVVSFLLSRGVHRVVALHYAHRPGMARALNAYVAEVAREEPRVLGLATVLPGEPDATAVLEEAFDAGLRGVKIHCHVQCFSPDAPHLHEVYAACAKAGRPLVMHAGREPSSPHYNCDTYALCAAERVERVLKDHPTLKLCVPHLGADEFDAYARLLERHDNLWLDTTMALAGYFPVPIPRRALEVRPERIIYGTDFPNIPYAWDRELRTMLGMKLDDAVLAGILGQNALQLYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCU9</accession>
    <name>Q1DCU9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1267"/>
    <dbReference type="EnsemblBacteria" id="ABF92178">
        <property type="protein sequence ID" value="ABF92178"/>
        <property type="gene ID" value="MXAN_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1267"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926963_0_0_7"/>
    <dbReference type="OMA" id="CVAMFTE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="33076" checksum="375037D95DF2949E" modified="2006-07-11" version="1">MSLGRLAGRARFCVRCRSPRPFMPVTVEQLGPHDAEALRGLLSKDPVHNLYLLGLLEEFGIAPRGRVPFAFYGRFDSQVLTAAVFVGGDGGLVVPSASDAGATSVIADALSSRLTLRSTVGDKSSVDALLRSLAPGKPRLSRTQRLFSVSADDLGPFTNPLLRLAKEEDLPRLLPLAQGYVREVHERDPLAEDPRGYEARVIQRVRQRRTYVLEENGALVFKVDIGSRSQYGAELEGLYTLPAERKKGHALLCLGQISRHLLSSLPRLTLRIDERDESTARIARKVGYLAGRTWRLVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD57</accession>
    <name>Q1DD57_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sufS</name>
        <name evidence="9" type="ORF">MXAN_1156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551276.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1156"/>
    <dbReference type="EnsemblBacteria" id="ABF93134">
        <property type="protein sequence ID" value="ABF93134"/>
        <property type="gene ID" value="MXAN_1156"/>
    </dbReference>
    <dbReference type="GeneID" id="41358607"/>
    <dbReference type="KEGG" id="mxa:MXAN_1156"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_7"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF93134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="407" mass="44753" checksum="A072A4A22D87DD27" modified="2006-07-11" version="1">MSGFDVNQVRKDFPILDQEVRGRPLVYLDSAATAQKPQAVIDALVRFYQHDNANVHRGVHVLSERATEAYEGARETVRRFINARDVKEVVFVRGTTEAINLVAQTYGRKHIGAGDEVLITQMEHHANIVPWRMLCEQTGAVLKVIPVDDRGELVLDAVDALLTERTRILAVTHVSNALGTVAPVKELTRRAHAKGIPVLVDGAQAVTHFPVDVQDLGCDFYAFSGHKMFGPTGIGVLYGRKERLDAMPPYQGGGDMILSVTMEKVTYNRVPYRFEAGTPNLEGAVGLAAAIRYLEALGMENVAAHDRELLAYATQALESVPGLRMVGTAREKSGVLSFMLADIHPHDVGTILDREGICIRTGHHCAQPVMQHFKVPATSRASLALYNTREDVDALVRGLHKVLEVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE6</accession>
    <name>Q1DDE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89831">
        <property type="protein sequence ID" value="ABF89831"/>
        <property type="gene ID" value="MXAN_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1067"/>
    <dbReference type="eggNOG" id="ENOG5030T17">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989813_0_0_7"/>
    <dbReference type="OMA" id="AFADWAW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="32562" checksum="C3D35A21E94AF414" modified="2006-07-11" version="1">MGVRSGGNIRTMDVVLRPISDRFFHEHLLPFFQRAMGDAPGALESLQEQLGDGQARMLCERMLATALPGGVGSVDADPWADLVDRLVFLHWTEGPAGWEVGEAEAGYADGWDEALHLALMVEEADYPYWDARGSRDVRDRFRFRPREDVGLASLLAGLWEPFPEFPPDQVFTTQGRGEYSPVTRYAFADWAWRPAKKVAHWQVNLPRKLERLLTREQARMKLPSLPEKEEVLAYWLGKQPQPPPLTVAFSGLGPRAANWIRELGALTAHLRGAALAKQGLAALVTKGSGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDJ2</accession>
    <name>Q1DDJ2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551141.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1020"/>
    <dbReference type="EnsemblBacteria" id="ABF91354">
        <property type="protein sequence ID" value="ABF91354"/>
        <property type="gene ID" value="MXAN_1020"/>
    </dbReference>
    <dbReference type="GeneID" id="41358475"/>
    <dbReference type="KEGG" id="mxa:MXAN_1020"/>
    <dbReference type="eggNOG" id="COG3419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253163_0_0_7"/>
    <dbReference type="OMA" id="CHESESA"/>
    <dbReference type="OrthoDB" id="5588at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188419" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1456" mass="158758" checksum="641C8534835182AD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDL7</accession>
    <name>Q1DDL7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551116.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0995"/>
    <dbReference type="EnsemblBacteria" id="ABF88981">
        <property type="protein sequence ID" value="ABF88981"/>
        <property type="gene ID" value="MXAN_0995"/>
    </dbReference>
    <dbReference type="GeneID" id="41358451"/>
    <dbReference type="KEGG" id="mxa:MXAN_0995"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="FPREQFW"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030287">
        <property type="entry name" value="FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF675">
        <property type="entry name" value="PTHR24220:SF675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="351" mass="38560" checksum="666F87ACB452CF2D" modified="2006-07-11" version="1">MARLFVEDLHVRLGANDILKGITADFRDGEVVALLGRSGSGKSTLLRSVAGLETPVRGRIHIGERTVFDAAAKVNLPPERRDLGLVFQSYALWPHKTVFDNVAYGLRLRKQPREQVERAVREVLQGVGLEGYGDRFPSQLSGGQQQRVALARALVYGPPLVLLDEPLSNLDAKLREEARVWIRALIKRLGLTALFVTHDQVEAMAIADRIMLLDGGRMVQDGTPEQLYTEPRSLFAADFMGVNNTLSGRVVERRGGEARLQVGSQSLWGLRRGDGSGGDTATGVIRVEELQLASGPGENRLPAALVNSIYVGGRWEHQFHAAGQTLRASTRQVLAPGAYTLAFPKERLWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDQ1</accession>
    <name>Q1DDQ1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551082.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0961"/>
    <dbReference type="EnsemblBacteria" id="ABF92502">
        <property type="protein sequence ID" value="ABF92502"/>
        <property type="gene ID" value="MXAN_0961"/>
    </dbReference>
    <dbReference type="GeneID" id="41358420"/>
    <dbReference type="KEGG" id="mxa:MXAN_0961"/>
    <dbReference type="HOGENOM" id="CLU_1007703_0_0_7"/>
    <dbReference type="OMA" id="GTFVELW"/>
    <dbReference type="OrthoDB" id="1219919at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011752">
        <property type="entry name" value="PilV_Myxo-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02266">
        <property type="entry name" value="gmx_TIGR02266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29130" checksum="6133D5A747580F1F" modified="2006-07-11" version="1">MPVFGLAALWNGSAPPERVAAWVEGIGEVLTSAQSLQLVVALRPEEAGIELKVEAPGYPRSAVERLAEDAKRSGGTFVELWRLPKAERDAFRAAAFGGGTTFRGDECSAAARVLQQHLTTLPVSSVRPAGPTVGGAAASVPQPSPKPVEAPAPSPSSPHHQVLVRPPEGPQRRGRRFAVKLEMEFRTELDFVREHALNISNGGLFVRTAHRPLPDSVVTVDVKLPNGERLQGDAVVVHVVDDPYTGGVGLAFLNDDATFSQTLDDYLASLAGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDS1</accession>
    <name>Q1DDS1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551062.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0941"/>
    <dbReference type="EnsemblBacteria" id="ABF92142">
        <property type="protein sequence ID" value="ABF92142"/>
        <property type="gene ID" value="MXAN_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="41358400"/>
    <dbReference type="KEGG" id="mxa:MXAN_0941"/>
    <dbReference type="eggNOG" id="ENOG5032W27">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1452679_0_0_7"/>
    <dbReference type="OMA" id="MNPIVHA"/>
    <dbReference type="OrthoDB" id="1915662at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="20338" checksum="016D18FA35D052A4" modified="2006-07-11" version="1">MNPIVHAELAWLAAQGLKERRDRILVTCAGLAPDLDGLTLLAGEAYYVRYHHVIFHGYVGAIVTAVACAALARQRLRVAALSLCTFHLHLLCDLAGSGPGWPIYYYWPTSMREWFWEGQWNLASWQNAVIGLATTLLCLACALRFRRTFVEVFSARWDAEVTRTLRRRFLREDFVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT8</accession>
    <name>Q1DDT8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMP_b-brl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="TCDB" id="1.B.6.5.4">
        <property type="family name" value="the ompa-ompf porin (oop) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93045">
        <property type="protein sequence ID" value="ABF93045"/>
        <property type="gene ID" value="MXAN_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0924"/>
    <dbReference type="HOGENOM" id="CLU_1353461_0_0_7"/>
    <dbReference type="OMA" id="KEWWVSK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188427" description="OMP_b-brl domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="22449" checksum="01EA71DB669CDF62" modified="2006-07-11" version="1">MGFSEGAVFMRYPSIIAALLFTATTASAQEYDEHAHDGFYLRLQVGGGYLRAKATDVSPDLVVKGGGANINAELGFALVNNFILYAKFYGASAPNPSLQVGDLTVEGQNENLSENFGAVGLGVTYYIMPANVYLSGALTYTQLSVTDDGEKVAESDIGGGLHLGVGKEWWVSKNWGLGIGAELALGRIRNESNSDSWNVTNVSLVFSATYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT9</accession>
    <name>Q1DDT9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551044.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0923"/>
    <dbReference type="EnsemblBacteria" id="ABF91333">
        <property type="protein sequence ID" value="ABF91333"/>
        <property type="gene ID" value="MXAN_0923"/>
    </dbReference>
    <dbReference type="GeneID" id="41358382"/>
    <dbReference type="KEGG" id="mxa:MXAN_0923"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_7"/>
    <dbReference type="OMA" id="FQPGPWM"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27617" checksum="91CD1F3F8ED6E09C" modified="2006-07-11" version="1">MSRKVALITGASAGLGEQFAHLFAKDGHDVILVARSATRLEALAAKLEQAHGVKAHVFPADLGRPESPEQLFEAVRAKGLAVEFLVNNAGFGSCGPFLAQDLAREAEMVEVNCTALLKLSHLFARPMQERGSGRILNVASTAAFQPGPFMATYFATKAFVVSLSEALAHELKGTGVTVTCHCPGATHTEFTQRAGNGQTRLFQQPGVAKAEDVAAHAYAMMMRGRVLSIHGLLNWVGTLGVRFSPRVAVRALAASLNQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDZ5</accession>
    <name>Q1DDZ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550988.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0867"/>
    <dbReference type="EnsemblBacteria" id="ABF91613">
        <property type="protein sequence ID" value="ABF91613"/>
        <property type="gene ID" value="MXAN_0867"/>
    </dbReference>
    <dbReference type="GeneID" id="41358326"/>
    <dbReference type="KEGG" id="mxa:MXAN_0867"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624345_0_0_7"/>
    <dbReference type="OMA" id="TVMELTM"/>
    <dbReference type="OrthoDB" id="1371596at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="20069" checksum="72C0220E834E37D6" modified="2006-07-11" version="1">MRGTWGAGGRAHGRYDGRTMLALDLVERLRQVSPSAANALLTVAVKNIIPLSSVMGVRVEDASDARAQVSVPLKRRTRNHVGSVYLGVQVTVMELTMGVWLFRRFPPGRYLALVNELQVSFHAKAKGGVRAICEPPPEVFNTLDAALRQKGDKAREWIPVRLEDFEGTHIADARFLAVLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE27</accession>
    <name>Q1DE27_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92511">
        <property type="protein sequence ID" value="ABF92511"/>
        <property type="gene ID" value="MXAN_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0834"/>
    <dbReference type="HOGENOM" id="CLU_3404481_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="30" mass="2970" checksum="DF0ABEA475156794" modified="2006-07-11" version="1">MGDSFTLALFMFQPSPGGSPAGLPGDGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE64</accession>
    <name>Q1DE64_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550919.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0796"/>
    <dbReference type="EnsemblBacteria" id="ABF90239">
        <property type="protein sequence ID" value="ABF90239"/>
        <property type="gene ID" value="MXAN_0796"/>
    </dbReference>
    <dbReference type="GeneID" id="41358262"/>
    <dbReference type="KEGG" id="mxa:MXAN_0796"/>
    <dbReference type="eggNOG" id="ENOG5032QH6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093384_0_0_7"/>
    <dbReference type="OMA" id="GACCGLY"/>
    <dbReference type="OrthoDB" id="1742529at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="269" mass="29589" checksum="13FBEA8171B0F2BF" modified="2006-07-11" version="1">MTVSFHLCQPGGGASCGACCGLYNFRDHSRLAVAEQLSMQTERLRRVPWEASAWHEAARELLAARRAEPMFSAVRVCPLLGFVDNERKQVGCLAHPLVTGGTDLRDCGVYRSSVCETFTCPSFGWLTDAQAKLVQVACADWYLYGLVITDVEFVRGCLRLLEWELAGPARPEVLMEQPEALAAIRRMFALKETAPRRGTNATVFGRFNRDADGEPVPRTVDYVKLGVRASPEDDVVLCLGYAPKDATELMGARELVRSHVKAVARALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE97</accession>
    <name>Q1DE97_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ung</name>
        <name evidence="12" type="ORF">MXAN_0760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550886.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0760"/>
    <dbReference type="EnsemblBacteria" id="ABF87223">
        <property type="protein sequence ID" value="ABF87223"/>
        <property type="gene ID" value="MXAN_0760"/>
    </dbReference>
    <dbReference type="GeneID" id="41358229"/>
    <dbReference type="KEGG" id="mxa:MXAN_0760"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_7"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="OrthoDB" id="1260295at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="51"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF87223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="225" mass="24889" checksum="48A5D19F654E1203" modified="2006-07-11" version="1">MLAEGLPEDWKQELRAALASPSFHELERFVEAERREATVFPSEEDLFSAFRLTPYEDVRVLLLGQDPYHGPGQAHGLAFSVKPGVAPPPSLVNMFKELESDVGVPRPKDGSLIPWARQGVLLLNAVLTVRQAKPNSHAGHGWEDFTDAVIRAVSAKDDPVVFLLWGRYAQKKKKLIDSKRHVVIEGTHPSPLSASNGFFGSRPFSAVNEALESHGRPPIDWRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEH4</accession>
    <name>Q1DEH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF subfamily RNA polymerase sigma-70 factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0681</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2020" name="ACS Chem. Biol." volume="0" first="0" last="0">
            <title>Biosynthesis of cittilins, unusual ribosomally synthesized and post-translationally modified peptides from Myxococcus xanthus.</title>
            <authorList>
                <person name="Hug J.J."/>
                <person name="Dastbaz J."/>
                <person name="Adam S."/>
                <person name="Revermann O."/>
                <person name="Koehnke J."/>
                <person name="Krug D."/>
                <person name="Muller R."/>
            </authorList>
            <dbReference type="PubMed" id="32639716"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DK 1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MN731368">
        <property type="protein sequence ID" value="QLH55581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550811.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0681"/>
    <dbReference type="EnsemblBacteria" id="ABF87434">
        <property type="protein sequence ID" value="ABF87434"/>
        <property type="gene ID" value="MXAN_0681"/>
    </dbReference>
    <dbReference type="GeneID" id="41358156"/>
    <dbReference type="KEGG" id="mxa:MXAN_0681"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_0_7"/>
    <dbReference type="OMA" id="RYEDTDW"/>
    <dbReference type="OrthoDB" id="1469807at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLH55581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="44895" checksum="84FA81BA79A6CA54" modified="2006-07-11" version="1">MMDTSSILERAHREDYGRIVATLIRVLDGDFGAAEEVVQDAFAAALNQWPREGVPREPAGWLMRVARNKAVDRMRRSARLEARVGELEAVAPSVDDAEWQTLPDDSLRLLFTCCHPALSPEAQVALALRCLCGLTTEQIARAFIVSPATLAQRLVRAQRKIRTARIPYVIPEPEALAERTEGVLHTLYLVFSEGYAATDGPALLRVDLCEEALRLARLARSLLPGDAEVASLRALMLLHHSRRRARVAADGGLVLLDRQDRSLWDGAQRDEGLAELGAALAMGARGPYTVQAAIAALHAQAPRAEDTDWAQIAALYARLVVLTPGPVVALNHAAAVAMARGPEHGLSLVDDLEASGRLADYHLLPAARADLLRRLGRKDEAASAYRRALAMVRTAPERRFLEARLLELLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEK8</accession>
    <name>Q1DEK8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550778.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0647"/>
    <dbReference type="EnsemblBacteria" id="ABF86658">
        <property type="protein sequence ID" value="ABF86658"/>
        <property type="gene ID" value="MXAN_0647"/>
    </dbReference>
    <dbReference type="GeneID" id="41358124"/>
    <dbReference type="KEGG" id="mxa:MXAN_0647"/>
    <dbReference type="HOGENOM" id="CLU_127071_0_0_7"/>
    <dbReference type="OrthoDB" id="2138522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="184" mass="20226" checksum="1E2A1A0C570A46D5" modified="2006-07-11" version="1">MRGYMRGVAIASMMGLIGCGEDDTYVYDMSLDAAALSNVPNECSGQLKAQFEGDGPATGIEAQQQWRLQRGEMDSMTLEMPDLNIRAPGITGYNVDADDEPDIFHGSVGADGGFQFVQTKVTNFGFEWGAYQAFSIVITNKHLDDTIHGHLWFRSEHLVAPPVADWDEAECVVTIPFTGKRVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DES7</accession>
    <name>Q1DES7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TonB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_0578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550709.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0578"/>
    <dbReference type="EnsemblBacteria" id="ABF90059">
        <property type="protein sequence ID" value="ABF90059"/>
        <property type="gene ID" value="MXAN_0578"/>
    </dbReference>
    <dbReference type="GeneID" id="41358058"/>
    <dbReference type="KEGG" id="mxa:MXAN_0578"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982905_0_0_7"/>
    <dbReference type="OMA" id="ELPFNYH"/>
    <dbReference type="OrthoDB" id="2056855at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="197"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF90059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="29186" checksum="0FF5C322E800A414" modified="2006-07-11" version="1">MPDAAAKARMPEDVLFASAFRGHETEAWSRQRTLMLVLAVIGLHAAALTGAASFWHGTPRRLEGETTRGEVLVLRLTAMSPSAPVGDVTGPAPAPLRPRTARRPRPSRAPSPPRTAAAPRASELAEPLSVGRPASIPAHDRDSLAGRAVAGITQRALGPGFPGLLVEPPPATAPDNREDMARRYFEQMFRDRFEDVPYPHEARMAGIEGSLVLRISVGVQGQLVALGVLGPCPHPLLCEAAQEAVRHAAPFPPPPPALGDRVTVELPFNYHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF23</accession>
    <name>Q1DF23_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="5">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glyoxalase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gloA</name>
        <name evidence="13" type="ORF">MXAN_0480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-S-lactoylglutathione = glutathione + methylglyoxal</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550613.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0480"/>
    <dbReference type="EnsemblBacteria" id="ABF85955">
        <property type="protein sequence ID" value="ABF85955"/>
        <property type="gene ID" value="MXAN_0480"/>
    </dbReference>
    <dbReference type="GeneID" id="41357972"/>
    <dbReference type="KEGG" id="mxa:MXAN_0480"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_8_1_7"/>
    <dbReference type="OMA" id="NWGTESY"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="12">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF85955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14403" checksum="51EAA6CB8A4116DD" modified="2006-07-11" version="1">MRILHTMLRVGDLERSLDFYTRIIGMKLLRRHDYPDGKFTLAFVGFGPEDTHPALELTYNWGVEKYELGTAYGHVALGVSDIHGTCEAIRQAGGKVVREPGPMKHGTTVIAFVEDPDGYKVELIQKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFS1</accession>
    <name>Q1DFS1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550366.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="myxxd-q1dfs1">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90107">
        <property type="protein sequence ID" value="ABF90107"/>
        <property type="gene ID" value="MXAN_0220"/>
    </dbReference>
    <dbReference type="GeneID" id="41357721"/>
    <dbReference type="KEGG" id="mxa:MXAN_0220"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_7"/>
    <dbReference type="OMA" id="HFRCLVL"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188489" evidence="2">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="83"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="43052" checksum="67FD86FEE94A8CEC" modified="2006-07-11" version="1">MSTSRAFTALLLAAGLSSAGCVRSYAHQPALSFQDLDYTSEGSKQPWPVKRIPLPRTANQYGMAVVPQIAYVDMPGSGPDAKAVVFIHGLGSYLKFWRAQLDAFQKQGYRVIAVDLPGYGKSDKPGTFPYTMEAMADAVLELVDGLGLDKPVLAGHSMGGQTSLSFAIRYPESLSGLVLASPAGFEKFSWREKEWFARAMSSEFIKSAPEASIWGSVRQANFMHWRPELEWLIEERVRLAKSPEFDAYAYANVRTVRGLSHNDFVRDNLHRVTVPTVIIYGTDDRLIPSPFLHGGETRGIMEYGASHIPGAKLVALEGCGHTVQLDCAERFNEAAFAFVRDAAAGRIEVPSAPAKEEAPRPESPPAPASEPLTPESLPPPTPGQEGEPTPGVLPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG48</accession>
    <name>Q1DG48_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_0092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550239.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0092"/>
    <dbReference type="EnsemblBacteria" id="ABF91617">
        <property type="protein sequence ID" value="ABF91617"/>
        <property type="gene ID" value="MXAN_0092"/>
    </dbReference>
    <dbReference type="GeneID" id="41357599"/>
    <dbReference type="KEGG" id="mxa:MXAN_0092"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_0_1_7"/>
    <dbReference type="OMA" id="LMYMSSS"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF91617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1046" mass="112378" checksum="BC1CD5AFE55E00B3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG70</accession>
    <name>Q1DG70_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550217.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0070"/>
    <dbReference type="EnsemblBacteria" id="ABF92448">
        <property type="protein sequence ID" value="ABF92448"/>
        <property type="gene ID" value="MXAN_0070"/>
    </dbReference>
    <dbReference type="GeneID" id="41357577"/>
    <dbReference type="KEGG" id="mxa:MXAN_0070"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585035_0_0_7"/>
    <dbReference type="OMA" id="SACPDEN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="98"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="478" mass="50467" checksum="075FEF6136ABDC00" modified="2006-07-11" version="1">MNSLHRPPMSACPDENLLAAFVSGSAPVGKVAVVEAHLDGCADCRALVAAVAASSSLPGAVVVEREAEAPTRWDTGAATLPDAREEPVLPPGTRLGAYLLQGVLGMGGMGVVYAADDLRLGRRVALKLLRPLLAGAQDQGRERLLREAQAMARLSHPNVLPLFELGTAEGHDFLAMEWVDGTTLADWLRERERPWRDVLDVFLAAGAGLAAAHRAGVVHRDFKPSNVLVGRDGRVRVTDFGLARRGTGESPEAPAGVSEGASKASMLTEWGQAAGTPAYMSPEQRAGRAVDARGDQYSFCVALHEALHGERPGHLAASAAPRTSSVPRHLRTALARGLANAPEDRFPSMEALMAALSLPSPAWGRRGILALAGAGSLVVLGVLLWKPSFLFQSDAATPRAESLGRMAASLIVLRVGDVHELAVPGLQRIAVGEPSLVEVTVPRQGVVRLKGKEEGSTDLITWSHAGEMKSRVLDVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVF6</accession>
    <name>Q1CVF6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557415.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7514"/>
    <dbReference type="EnsemblBacteria" id="ABF91747">
        <property type="protein sequence ID" value="ABF91747"/>
        <property type="gene ID" value="MXAN_7514"/>
    </dbReference>
    <dbReference type="GeneID" id="41364647"/>
    <dbReference type="KEGG" id="mxa:MXAN_7514"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439293_0_0_7"/>
    <dbReference type="OMA" id="YTARTEV"/>
    <dbReference type="OrthoDB" id="918481at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="SSF48431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="622" mass="67631" checksum="5CD9E9EC6432854B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVM5</accession>
    <name>Q1CVM5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">MXAN_7443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557351.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7443"/>
    <dbReference type="EnsemblBacteria" id="ABF89290">
        <property type="protein sequence ID" value="ABF89290"/>
        <property type="gene ID" value="MXAN_7443"/>
    </dbReference>
    <dbReference type="GeneID" id="41364592"/>
    <dbReference type="KEGG" id="mxa:MXAN_7443"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_7"/>
    <dbReference type="OMA" id="IYYAYVT"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="48099" checksum="5406A4F4D3B083F1" modified="2006-07-11" version="1">MEPEAESVHEDELRDAWPALSARERVEGFHLLPPERARDFFATLNAPAQLGLLEALSPGERGTWLRAMAPDDAADVVQRLSPEAREAWLALLDAPSLREVRALLAYGEDAAGGLMNPRFVRVRPEMRIDEALSYLRRQAREQVETVYYAYVLDEAQRLKGVVSLRQLFQATPDKAVREVMRTELIRVREDTDQEEVGRLFARYGLAAIPVVDDQGLMKGIVTVDDIVSVVQAEATEDIQKVGGTEALGAPYLEVGLPAMLKKRAGWLLVLFLSEMLTATAMTRYQDEIARAVVLSLFVPLIISAGGNAGSQASTLVIRALALAQVRLRDVVRVLRRELLSGLALGLVLGSVGVARILLWQVLFHLYGEHAFRVALTVGLAVLGVVTWGTLAGSMLPFLLRRLGFDPASASAPFVATLVDVSGLVIYFTTAELILRGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW59</accession>
    <name>Q1CW59_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557170.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7251"/>
    <dbReference type="EnsemblBacteria" id="ABF89520">
        <property type="protein sequence ID" value="ABF89520"/>
        <property type="gene ID" value="MXAN_7251"/>
    </dbReference>
    <dbReference type="GeneID" id="41364417"/>
    <dbReference type="KEGG" id="mxa:MXAN_7251"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_273085_0_0_7"/>
    <dbReference type="OMA" id="LAHEFQT"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132519" checksum="89EB3C6876FE9871" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWJ2</accession>
    <name>Q1CWJ2_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7118"/>
    <dbReference type="EnsemblBacteria" id="ABF86449">
        <property type="protein sequence ID" value="ABF86449"/>
        <property type="gene ID" value="MXAN_7118"/>
    </dbReference>
    <dbReference type="GeneID" id="41364292"/>
    <dbReference type="KEGG" id="mxa:MXAN_7118"/>
    <dbReference type="eggNOG" id="ENOG5032BPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452573_0_0_7"/>
    <dbReference type="OMA" id="GYRFICE"/>
    <dbReference type="OrthoDB" id="402420at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="623" mass="66898" checksum="BC875E52B340D2FB" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWS9</accession>
    <name>Q1CWS9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88802">
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        <property type="gene ID" value="MXAN_7031"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_7031"/>
    <dbReference type="eggNOG" id="COG5184">
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    </dbReference>
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    <dbReference type="OMA" id="SRICANA"/>
    <dbReference type="OrthoDB" id="555014at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="554" mass="59645" checksum="E1817B15C9C54E90" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX02</accession>
    <name>Q1CX02_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator DotR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dotR</name>
        <name evidence="3" type="ORF">MXAN_6956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6956"/>
    <dbReference type="EnsemblBacteria" id="ABF86665">
        <property type="protein sequence ID" value="ABF86665"/>
        <property type="gene ID" value="MXAN_6956"/>
    </dbReference>
    <dbReference type="GeneID" id="41364134"/>
    <dbReference type="KEGG" id="mxa:MXAN_6956"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="RACFNSG"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52172"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14269" checksum="26A1FA992CEFB2D4" modified="2006-07-11" version="1">MTAQGAPRRKKVLLVDDSDTVLLLQRMLLAELGHDAIVARDGLEALARAEQERPDLVFLDVLMPHLDGLETCRLLRDREPTRRTPIILCSARAEARSVRACFNSGCNDFVAKPFDGAALVALLRRYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX18</accession>
    <name>Q1CX18_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene dehydrogenase</fullName>
            <ecNumber evidence="6">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carC</name>
        <name evidence="6" type="ORF">MXAN_7517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556861.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CX18"/>
    <dbReference type="STRING" id="246197.MXAN_7517"/>
    <dbReference type="EnsemblBacteria" id="ABF88212">
        <property type="protein sequence ID" value="ABF88212"/>
        <property type="gene ID" value="MXAN_7517"/>
    </dbReference>
    <dbReference type="GeneID" id="41364121"/>
    <dbReference type="KEGG" id="mxa:MXAN_7517"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_7"/>
    <dbReference type="OMA" id="FLEYEHG"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="58407" checksum="410A740A01B606E5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX57</accession>
    <name>Q1CX57_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556822.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6902"/>
    <dbReference type="EnsemblBacteria" id="ABF90940">
        <property type="protein sequence ID" value="ABF90940"/>
        <property type="gene ID" value="MXAN_6902"/>
    </dbReference>
    <dbReference type="GeneID" id="41364085"/>
    <dbReference type="KEGG" id="mxa:MXAN_6902"/>
    <dbReference type="HOGENOM" id="CLU_1045505_0_0_7"/>
    <dbReference type="OMA" id="LRCPARM"/>
    <dbReference type="OrthoDB" id="723872at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="28263" checksum="26A08BBD14B8E7B0" modified="2006-07-11" version="1">MPMGDADTLPRQAEAFLAAHPGASLVALGSGEHAGSLDLSPLGVPVTFLPAERNADLAMQYLALNQLAFGGIGVPRWVLSDLYLLPGAIGLLRCPARMLAAPVRERLGLADEDPAIGAAYYAAPSVTPGLVIGVSLLSVLPGTGASPWVKLLTLQMLRARRLRGVAQWDNPSVRVHSRLGPLRLVGRVPGGHEYGERSFVYESELTDRTRLGDAMVRRLSLTPSLRVSATDLSALSALLDRAEAGEVLHLVPPGLDAGQVLVREGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXF9</accession>
    <name>Q1CXF9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556722.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88307">
        <property type="protein sequence ID" value="ABF88307"/>
        <property type="gene ID" value="MXAN_6797"/>
    </dbReference>
    <dbReference type="GeneID" id="41363987"/>
    <dbReference type="KEGG" id="mxa:MXAN_6797"/>
    <dbReference type="HOGENOM" id="CLU_1914813_0_0_7"/>
    <dbReference type="OMA" id="NPRFVYR"/>
    <dbReference type="OrthoDB" id="2077752at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="132" mass="13958" checksum="F17DAEB3DE0698F9" modified="2006-07-11" version="1">MMTHVLRNPRFVYRFDAAASLLMGVALLLLAPTLTQLAGWRLPSTFLFGVGLFLLPWSAFNLWVGLKQPVLGAALVHLLVDAAWVVGSVLLVVMHAQELTPLGTALLAGQAFAVAGVLALKAVGLTSLRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXT2</accession>
    <name>Q1CXT2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556599.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6674"/>
    <dbReference type="EnsemblBacteria" id="ABF85869">
        <property type="protein sequence ID" value="ABF85869"/>
        <property type="gene ID" value="MXAN_6674"/>
    </dbReference>
    <dbReference type="GeneID" id="41363872"/>
    <dbReference type="KEGG" id="mxa:MXAN_6674"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021033_0_0_7"/>
    <dbReference type="OMA" id="GWKIHDA"/>
    <dbReference type="OrthoDB" id="159386at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="508"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="686" mass="72612" checksum="6EC7BA9836A56B74" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXU2</accession>
    <name>Q1CXU2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter, permease protein LivH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livH</name>
        <name evidence="7" type="ORF">MXAN_6664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556589.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6664"/>
    <dbReference type="EnsemblBacteria" id="ABF87966">
        <property type="protein sequence ID" value="ABF87966"/>
        <property type="gene ID" value="MXAN_6664"/>
    </dbReference>
    <dbReference type="GeneID" id="41363862"/>
    <dbReference type="KEGG" id="mxa:MXAN_6664"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_7"/>
    <dbReference type="OMA" id="YIVGCFM"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="306" mass="32574" checksum="EF35E505A0531788" modified="2006-07-11" version="1">MAQLLQHLINGLAAGTIYALVALGYTMVYGVLKLINFAHGDVMMVGVYMGYATAFALGRDMRSSLLGVAVVFAVAMLGCALLGFLIERFAYRPLREKPRLTALITAIGISFALSYGFQLDLGFLPGAAPRAFPEVIEPVEWLVIGDRDVVVWNWQVISFGIAVALMVGLQYLVFRTRFGRAMRAVSWDHRVAALMGIPTDRVIALTFMLSSALAAGAGLLYAIKDTSVSPLMGLYVGLKAFVAAVIGGIGHVPGAVVGGLVLGLVEEFVVGYAASTWRDAVAFGFLILVLLVKPGGLFGRVAAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXY1</accession>
    <name>Q1CXY1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AhpC/TSA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6624"/>
    <dbReference type="PeroxiBase" id="4364">
        <property type="entry name" value="MxBCP02"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89674">
        <property type="protein sequence ID" value="ABF89674"/>
        <property type="gene ID" value="MXAN_6624"/>
    </dbReference>
    <dbReference type="GeneID" id="41363821"/>
    <dbReference type="KEGG" id="mxa:MXAN_6624"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_3_1_7"/>
    <dbReference type="OMA" id="SHRKFAT"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="27813" checksum="A9082839E9A71ECB" modified="2006-07-11" version="1">MPMPQAGDQAPAFQLADQDGNAVSLAQFAGRSVVLYFYPKDDTPGCTVEACGFRDEHSALEAAGAVVLGVSADSTASHRKFATKFNLPFPLLADVDHTLSEAYGVWGEKSLYGRKFLGITRATFLIGPDGVLKQVWPKVKVNGHVAEVLAVLKGEAPAAGGAVKKSAAKKAPAGKKVAAAKKAPAGKTVSGKSAATRKATAKKAAPAAKAPRAAKKAATAKKAPVAKKPAAAKKASAGKKPAAAKKASAGKKPAPAKKSAVAKKSAAAKKASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXZ3</accession>
    <name>Q1CXZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556538.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6612"/>
    <dbReference type="EnsemblBacteria" id="ABF88357">
        <property type="protein sequence ID" value="ABF88357"/>
        <property type="gene ID" value="MXAN_6612"/>
    </dbReference>
    <dbReference type="GeneID" id="41363810"/>
    <dbReference type="KEGG" id="mxa:MXAN_6612"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017817_0_0_7"/>
    <dbReference type="OMA" id="LWKWFVI"/>
    <dbReference type="OrthoDB" id="551360at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011933">
        <property type="entry name" value="Double_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02226">
        <property type="entry name" value="two_anch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="BatA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="95"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="699" mass="75034" checksum="E417E5BB2B498B3C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYM1</accession>
    <name>Q1CYM1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556310.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6377"/>
    <dbReference type="EnsemblBacteria" id="ABF86096">
        <property type="protein sequence ID" value="ABF86096"/>
        <property type="gene ID" value="MXAN_6377"/>
    </dbReference>
    <dbReference type="GeneID" id="41363589"/>
    <dbReference type="KEGG" id="mxa:MXAN_6377"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813347_0_0_7"/>
    <dbReference type="OrthoDB" id="1869430at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="352" mass="39002" checksum="509D0D43F4022019" modified="2006-07-11" version="1">MSEAVLRQQQLQAAEEAAARQSHTTPPDGVCMPCGLRSLRALEVCVVGEDDQGLMDVQVELRLAPGQLLRARTNREGRARFEGLEADARYTLGLPDLDAAAWELLAEEPLPAERAVSDVPAAWQQAPSAQPPRVPEAHVVDQGDCMSSIAHQHGFLPETLWNLPENAVLHAKQRQRHVLYPGDTITLPPRRARDEEARAGRLYRVRRKGIPDMLRLRFLDVDEEPRVGLPFLLRLRTFSGESVRDVRGELDGDGYVQATIPPDADLGELILGTGPDRETYQLELGHVDPLGTFPGLQDRLANLGYFSCCEQDSEHHPVTRQALERLQLAYGLKPTGKLDGASRELLKALHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ16</accession>
    <name>Q1CZ16_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556170.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6226"/>
    <dbReference type="EnsemblBacteria" id="ABF89464">
        <property type="protein sequence ID" value="ABF89464"/>
        <property type="gene ID" value="MXAN_6226"/>
    </dbReference>
    <dbReference type="GeneID" id="41363452"/>
    <dbReference type="KEGG" id="mxa:MXAN_6226"/>
    <dbReference type="eggNOG" id="ENOG5030PVG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134903_1_0_7"/>
    <dbReference type="OMA" id="ILSRIPW"/>
    <dbReference type="OrthoDB" id="1927917at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="17865" checksum="A213B47DD509B9DE" modified="2006-07-11" version="1">MLYSGVLLLHSWLRWAVVVLGVLALVRALMGWARARDWTPDDRRLQVFFVSAFDIQMLLGMTLYFALSPVTPRSLDALRMGMSISHLRFFSLEHPLLMLLALTAAHATSAMTRREAPAQSKHRTWAVGLLLAMLFVALAIPWPGLPHGRPCSGTSSQTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZC5</accession>
    <name>Q1CZC5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556062.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6113"/>
    <dbReference type="EnsemblBacteria" id="ABF92341">
        <property type="protein sequence ID" value="ABF92341"/>
        <property type="gene ID" value="MXAN_6113"/>
    </dbReference>
    <dbReference type="GeneID" id="41363348"/>
    <dbReference type="KEGG" id="mxa:MXAN_6113"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023163_0_0_7"/>
    <dbReference type="OMA" id="MSMAHEA"/>
    <dbReference type="OrthoDB" id="283608at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046278">
        <property type="entry name" value="DUF6311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19830">
        <property type="entry name" value="DUF6311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6311" evidence="2">
        <location>
            <begin position="34"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="580" mass="63632" checksum="8AC1F133042BC942" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZH7</accession>
    <name>Q1CZH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">MXAN_6061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556010.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6061"/>
    <dbReference type="EnsemblBacteria" id="ABF87119">
        <property type="protein sequence ID" value="ABF87119"/>
        <property type="gene ID" value="MXAN_6061"/>
    </dbReference>
    <dbReference type="GeneID" id="41363297"/>
    <dbReference type="KEGG" id="mxa:MXAN_6061"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_7"/>
    <dbReference type="OMA" id="IVMRPDA"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="36601" checksum="FA3142CE13689ADF" modified="2006-07-11" version="1">MLIVMRPDATAQDIERVNDEIRRRGWQPHAIPGGTRTAVGITGNPGAVEPEPFRVLPGVADAVAISQPFKLVSREVKPDDTQLRIGDLTIGGSAFHVIAGPCSVESREQILSTAHAVKKAGATMLRGGAFKPRTSPYEFQGLKGDGLALLAEARQETGLLVTTEVKDTATLQAVADTTDILQIGARNMQNFSLLEAVGDLRKPVMLKRGMSATIKELLMAAEYIVARGNTQVILCERGIRTFETMTRNTLDLNAVPMLKALSHLPVFVDPSHGIGVRKAVPAMMRAATAVGADGIIVEVHPDPPRAKSDGAQSLDFSEFEKSMNEVRAIAQAMGREVVRLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZI3</accession>
    <name>NHAA2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Na(+)/H(+) antiporter NhaA 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sodium/proton antiporter NhaA 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nhaA2</name>
        <name type="ordered locus">MXAN_6055</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29252"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556004.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZI3"/>
    <dbReference type="SMR" id="Q1CZI3"/>
    <dbReference type="STRING" id="246197.MXAN_6055"/>
    <dbReference type="EnsemblBacteria" id="ABF91686">
        <property type="protein sequence ID" value="ABF91686"/>
        <property type="gene ID" value="MXAN_6055"/>
    </dbReference>
    <dbReference type="GeneID" id="41363292"/>
    <dbReference type="KEGG" id="mxa:MXAN_6055"/>
    <dbReference type="eggNOG" id="COG3004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015803_1_2_7"/>
    <dbReference type="OMA" id="WHTPFGF"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0739">Sodium transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000334344" description="Na(+)/H(+) antiporter NhaA 2">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <sequence length="470" mass="49373" checksum="6BE94265134B2DE5" modified="2006-07-11" version="1">MSTTTPPGQSALPPEAWAPLLRLSRLAGRPLERFLHIEAASGILLLVAAAIALLWANSPWAESYAHFWHTPLGIRVGDFTFERSLEWVVNDGLMAIFFFVVGMEIRREVHQGELSELRRAALPAAAALGGMLVPAGLYLLLADTPDTRSGWGVPMATDIAFAVGILTLLGSRVPPALRVLLLALAVIDDLGAIIVIAVFYSSGVAITGLLVAALGIVGVFAMQRFGVRSKWAYIVPAFVAWAGVYSAGIHPTIAGVIIGLITPVRTWLGPEGFVTGARTELEHIAQAQPGELSSHHLSETLRRVDAARREAMSPSESLIATLHPWVAFGIMPVFALANAGVPISSEPLDAASWTVALATATGLLVGKPLGVIGACWLALRLRLATLPKGLGMRELLVLGSTAGIGFTMALFIAQLAFTETKLLAAGKLGVLAASGAAAVVALVLGRWLLTTSARPGAARSVDEAERSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZL1</accession>
    <name>Q1CZL1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555976.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6027"/>
    <dbReference type="EnsemblBacteria" id="ABF86588">
        <property type="protein sequence ID" value="ABF86588"/>
        <property type="gene ID" value="MXAN_6027"/>
    </dbReference>
    <dbReference type="GeneID" id="41363265"/>
    <dbReference type="KEGG" id="mxa:MXAN_6027"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="REMYGAF"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="258"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF86588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="531" mass="55482" checksum="641DC07F0D0BAF7E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D032</accession>
    <name>Q1D032_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555805.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5854"/>
    <dbReference type="EnsemblBacteria" id="ABF88714">
        <property type="protein sequence ID" value="ABF88714"/>
        <property type="gene ID" value="MXAN_5854"/>
    </dbReference>
    <dbReference type="GeneID" id="41363093"/>
    <dbReference type="KEGG" id="mxa:MXAN_5854"/>
    <dbReference type="eggNOG" id="ENOG50301N0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132647_0_0_7"/>
    <dbReference type="OMA" id="QELWIAM"/>
    <dbReference type="OrthoDB" id="955702at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29019" checksum="73D24B88E44A099C" modified="2006-07-11" version="1">MADSVPVIGSGAGNRAGEIVGVVPRAEYGRMVVLTTVMPMAIITTTWFLPPGWNLLGTAAMLTGFLLVLGKAIAGVPLALLISERNLMSLSRFQALVWTVVVMAGYLTMTLSRVKSGAPNAVGVDIPQELWIAMGISTTSLLGTPLVLGGKRARSPDEKLVQNTSVQLAEAPADIDAHRQGVLYANANMTDARMADMFQGDEVGNTAHIDLAKVQMFYFTLIAAVGYFMDVAMSVARGTTHAMPALSQGMLALLAISHGGYLLGKTGDHSNSKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D056</accession>
    <name>Q1D056_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF88762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D056"/>
    <dbReference type="STRING" id="246197.MXAN_5830"/>
    <dbReference type="EnsemblBacteria" id="ABF88762">
        <property type="protein sequence ID" value="ABF88762"/>
        <property type="gene ID" value="MXAN_5830"/>
    </dbReference>
    <dbReference type="GeneID" id="41363070"/>
    <dbReference type="KEGG" id="mxa:MXAN_5830"/>
    <dbReference type="HOGENOM" id="CLU_112879_0_0_7"/>
    <dbReference type="OMA" id="FSYPAVD"/>
    <dbReference type="OrthoDB" id="1236168at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21381" checksum="230724DD364EC19B" modified="2006-07-11" version="1">MGFPQNDLEQRLAVIRPDDTVRGLVFNAVFNLTEKKLGVEAATRLREPFFKRSPVDFFSYPAIDALRLLYATSEALTPVYGSMEDAVRACGAAAVTHFFQSTVGQTLNRLIGKGDPKRLLSHAPTAYSTLVSYGRREFAVLGDKQVRLAFHGDMQPVQYHEGVLKEALSVVGCKSRVVGTPRGVTGADYVITWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D7</accession>
    <name>Q1D0D7_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D0D7"/>
    <dbReference type="STRING" id="246197.MXAN_5749"/>
    <dbReference type="EnsemblBacteria" id="ABF86413">
        <property type="protein sequence ID" value="ABF86413"/>
        <property type="gene ID" value="MXAN_5749"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5749"/>
    <dbReference type="eggNOG" id="ENOG5032XYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094189_0_0_7"/>
    <dbReference type="OMA" id="NNPHIIT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="27841" checksum="503CA6337B3F73F2" modified="2006-07-11" version="1">MVGVSRTPSVSLYVSQPLSAFQRNCRAIAVACTVGGPGSHSCACGTTKDASRSRLPCVVRMRLLRSATSAMTKTFEKAVTGFNHNIKHKGKVYHVQTEDSGVNNPHIITHLFVGGNILASKKTSYADILNAENLAEVVRELMEEQHKEMLRNLINGVYDSYESTARSYQPGQLAADTDPAQVKLQPGQSMVQRPPPPPPPVAVPAPVVVPPEVAAARALKEKPKINEIGVETLFGEDLISEKSLDEVILSYLAGEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q0</accession>
    <name>Q1D0Q0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5634"/>
    <dbReference type="EnsemblBacteria" id="ABF91167">
        <property type="protein sequence ID" value="ABF91167"/>
        <property type="gene ID" value="MXAN_5634"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5634"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_1_7"/>
    <dbReference type="OMA" id="WIIGIHA"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="45755" checksum="B4274F060695537E" modified="2006-07-11" version="1">MWRPLSPGRHCRKPDGMSQQPSDSTASANRRKRLLLLGVLWLSLALVLLAFRSVVMPFAGAALIAYLVQPLVGRISRVKVAGRPVPRWTALLLIYAGFFVGVYLFIVALVPQLYRELSRVSREAVTFANTLTPEHVQELAQRAETWLSTRGIPVALSNRALEGADAGSSNGTFGFALDLEQFLGDAVKRVSILVQENLGDIVNVSRSIVTSVAAGVFMLFFVLMVAAFFSIDAHAIRRYFGTLIPPEYAIDARQLLERIDRSLSGVVRGQVTICIVNGILTFMGLLLFGVKFAFLLATIATFFSLIPIFGTILSSVPIVLIALADGFQKGLAILAWIIGIHAVEAYFLNPKIMGQAAHLHPVIVAFSLIAGERLFGLVGALFAVPVASVLVACFDYARLKAQPAPAVALATPGPLPAERQPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0S1</accession>
    <name>Q1D0S1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555567.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5613"/>
    <dbReference type="EnsemblBacteria" id="ABF87244">
        <property type="protein sequence ID" value="ABF87244"/>
        <property type="gene ID" value="MXAN_5613"/>
    </dbReference>
    <dbReference type="GeneID" id="41362859"/>
    <dbReference type="KEGG" id="mxa:MXAN_5613"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969204_0_0_7"/>
    <dbReference type="OMA" id="HMNDARA"/>
    <dbReference type="OrthoDB" id="1632937at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="13884" checksum="3D49595ED9205A8E" modified="2006-07-11" version="1">MNQVLEVRPGLAGAAIAAGRVETLMLEGELSEQDLLELCDDLGRKLQRGTRQVVLDFGDVGHLNYRGVKPLMARTDAFRRAGGDVKLSGLSPYLAAIFRAAGAHDCFEIYPHMNDARAAFALARAPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0X8</accession>
    <name>Q1D0X8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoredutase membrane subunit, NrfD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555510.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5556"/>
    <dbReference type="EnsemblBacteria" id="ABF86147">
        <property type="protein sequence ID" value="ABF86147"/>
        <property type="gene ID" value="MXAN_5556"/>
    </dbReference>
    <dbReference type="GeneID" id="41362804"/>
    <dbReference type="KEGG" id="mxa:MXAN_5556"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_7"/>
    <dbReference type="OMA" id="MVWWLAL"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="54980" checksum="0B878E19E7C11DF5" modified="2006-07-11" version="1">MSNQHLSPLREPLVTEPRSLGQLTEEICAPMERAPTWKWWVAFGIAVSVLGTGAGIVGYQVATGIGVWGLNKTIGWAFDITNFVFWVGIGHAGTLISAILFLFRQKWRTSINRAAEAMTLFAVMCAALFPVIHMGRPWLAFWVLPYPNDRGSLWVNFRSPLLWDVFAISTYFTVSAVFWYVGLIPDLATVRDRAKAGIRKAVFKVMSLGWTGSNRTWSRYETVYLLLAGLATPLVLSVHTIVSMDFATSVIPGWHTTIFPPYFVAGAVFSGFAMVLTLMIITRVVLGYEHLITLRHLENMTKIIIVTGGLVSLAYATEFFIAWYSGNPYERFAFMNRAFGPYAWAYWIMVTCNVVSPHLFWFKKIRTSPAAIFVLSLVINVGMWFERFVIIVTSLHRDFLPSSWAMYTPTMVEVGTFIGTFGLFFTLFLLFVRVLPIISIGEVKSVLGFARDGHAAQSHPPAKPVAEEPHPVAHRPASPVPLAIATRKDAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D113</accession>
    <name>Q1D113_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555475.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5517"/>
    <dbReference type="EnsemblBacteria" id="ABF88075">
        <property type="protein sequence ID" value="ABF88075"/>
        <property type="gene ID" value="MXAN_5517"/>
    </dbReference>
    <dbReference type="GeneID" id="41362770"/>
    <dbReference type="KEGG" id="mxa:MXAN_5517"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079613_0_0_7"/>
    <dbReference type="OMA" id="EERGHCW"/>
    <dbReference type="OrthoDB" id="1574434at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="32298" checksum="5FCD418EF334D38E" modified="2006-07-11" version="1">MNPTCPTCHTPHPGAEAGPRRTCAACGADLTPGAQARSTPPEPDLTGESLAGFQLNSRLGTDATGSLYAAEGHVGPCVVKVMSSSVTADAEARARFHREAETLRSLRHPGIVRVLAVGEERGHCWYALEPVIAPALEARLDRANALPFQEVEQLALRLLDALGAAHDTGLVHGDVRPQNILLAKDGAMLTNFGLSLVPPGAHGYQAPEQRQWGRAVPQSDLHALGRVLHEALTGGMPETQPLPQGVPRHLRRLLKSLLSEAIQDRPDSAISARRLLTQRAPLGPLAVGIAALLAMLMFLLLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D154</accession>
    <name>Q1D154_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555434.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5476"/>
    <dbReference type="EnsemblBacteria" id="ABF86079">
        <property type="protein sequence ID" value="ABF86079"/>
        <property type="gene ID" value="MXAN_5476"/>
    </dbReference>
    <dbReference type="GeneID" id="41362731"/>
    <dbReference type="KEGG" id="mxa:MXAN_5476"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322336_0_0_7"/>
    <dbReference type="OMA" id="FISSAQW"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="214"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="667"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="916" mass="98680" checksum="E9BF4AE3F8571C7D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D194</accession>
    <name>Q1D194_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555394.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91791">
        <property type="protein sequence ID" value="ABF91791"/>
        <property type="gene ID" value="MXAN_5434"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5434"/>
    <dbReference type="HOGENOM" id="CLU_2233626_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="105" mass="11567" checksum="210B9C7A61C98F2A" modified="2006-07-11" version="1">MGALLRGREGAEGPRRAADGAARVMLQAGGQAAQDLDSQMFLHDGPEKERFLADPLITHEKLPARSAKAFIAPLNRPTPAHHQYRERLLSLTCVLIQERNSETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Q2</accession>
    <name>Q1D1Q2_MYXXD</name>
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        <submittedName>
            <fullName evidence="5">S1D (Lysyl endopeptidase) subfamily C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555236.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5269"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87559">
        <property type="protein sequence ID" value="ABF87559"/>
        <property type="gene ID" value="MXAN_5269"/>
    </dbReference>
    <dbReference type="GeneID" id="41362547"/>
    <dbReference type="KEGG" id="mxa:MXAN_5269"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520446_0_0_7"/>
    <dbReference type="OMA" id="NTAMGMT"/>
    <dbReference type="OrthoDB" id="1957378at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="4">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="420"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="569" mass="59392" checksum="D5B41A74FAADD3DE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Z2</accession>
    <name>Q1D1Z2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">MXAN_5178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555149.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5178"/>
    <dbReference type="EnsemblBacteria" id="ABF88827">
        <property type="protein sequence ID" value="ABF88827"/>
        <property type="gene ID" value="MXAN_5178"/>
    </dbReference>
    <dbReference type="GeneID" id="41362461"/>
    <dbReference type="KEGG" id="mxa:MXAN_5178"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_0_1_7"/>
    <dbReference type="OMA" id="YEVAHVG"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="29262" checksum="993CCEAF0BA30335" modified="2006-07-11" version="1">MKIATWNVNSVRARQERLLAWLKKAQPDVLCLQELKCVDDDFPMEAVRELGYHAAVHGQKTYNGVAILAKEEPKDVVKGLSDGVDDSHARLIAATVGGIRVVSAYAPNGQSVDSPQYQYKLEWYGRLRRYLDTRHKPDEPLVLGGDWNVAPEDIDTYDPKLWEGQTLFTLKERDALQRLGAFGLSDAFRRLHPGVQKFTWWDYRMLGFPKNLGLRIDHLYVTAPVAERLTVVDVDREERKGKQPSDHAPVWLELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D214</accession>
    <name>Q1D214_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pesticin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555127.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5156"/>
    <dbReference type="EnsemblBacteria" id="ABF87840">
        <property type="protein sequence ID" value="ABF87840"/>
        <property type="gene ID" value="MXAN_5156"/>
    </dbReference>
    <dbReference type="GeneID" id="41362438"/>
    <dbReference type="KEGG" id="mxa:MXAN_5156"/>
    <dbReference type="eggNOG" id="COG5276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104591_0_0_7"/>
    <dbReference type="OMA" id="DLGARDM"/>
    <dbReference type="OrthoDB" id="1368760at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16902">
        <property type="entry name" value="pesticin_lyz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031922">
        <property type="entry name" value="Pesticin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16754">
        <property type="entry name" value="Pesticin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pesticin" evidence="4">
        <location>
            <begin position="89"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="30267" checksum="F35532D69588BBBE" modified="2006-07-11" version="1">MTGIDRSSSSRSSQRESRVSGGDAARGLRNETNRREDARQPEQNKAKGYSVKDGWDSRPAHAAKQSQPAVEAQAVAAEDGVAAATEPDVDWDFIAEQEGRAVQDGYVPDATGSKSGVTVGTGVDLGARDMNDLDRLGLSDALKTKLEPYLGKQGQDAADFLAENPLNLTAEEVKELDRAVKGEALDNVVKEYNTEVERLNAADGGSRPKFAELPREMQTVIASVGFQYGSLKTATPNFFAQVTEQRWDDAKANLEDFGDRYPSRRGREADLLGEGIATLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D295</accession>
    <name>SP5G_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVG</name>
        <name type="ordered locus">MXAN_5074</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SpoVG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002634160.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D295"/>
    <dbReference type="SMR" id="Q1D295"/>
    <dbReference type="STRING" id="246197.MXAN_5074"/>
    <dbReference type="EnsemblBacteria" id="ABF86940">
        <property type="protein sequence ID" value="ABF86940"/>
        <property type="gene ID" value="MXAN_5074"/>
    </dbReference>
    <dbReference type="GeneID" id="41362358"/>
    <dbReference type="KEGG" id="mxa:MXAN_5074"/>
    <dbReference type="eggNOG" id="COG2088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103669_2_1_7"/>
    <dbReference type="OMA" id="KDVAHPI"/>
    <dbReference type="OrthoDB" id="1871825at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_1000062434" description="Putative septation protein SpoVG">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <sequence length="99" mass="11234" checksum="F9B80E7DB1BC4362" modified="2006-07-11" version="1">MNITDVRVFPVEEDKLKAYVTITLDHCFVIRDLKVIHGSTGLFIAMPAKKRKDGTYKDIAHPLNADTRSQMERVILMEYERHLHQAQAGMLVAAPADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D298</accession>
    <name>Q1D298_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555046.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5071"/>
    <dbReference type="EnsemblBacteria" id="ABF91535">
        <property type="protein sequence ID" value="ABF91535"/>
        <property type="gene ID" value="MXAN_5071"/>
    </dbReference>
    <dbReference type="GeneID" id="41362355"/>
    <dbReference type="KEGG" id="mxa:MXAN_5071"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025690_0_0_7"/>
    <dbReference type="OMA" id="VLFPDPM"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="271" mass="29721" checksum="CAE8D426DC174337" modified="2006-07-11" version="1">MRDTLYSNVPFKLNEMPHHYGPHVHLVGNPFLLTQLATLCSKGVIQPQINRLVETLYVDLVKTVLNAEFPRKNVSLPTRMIDSTPQGLYQGEVIDPQVRVVTVNIARAGTLPSQVTYDLMNATLDPTVVRQDHIIMSRMIDAAEAVVGSEIGGAKIGGDVDDAFVLFPDPMGATGGSLSTAISLYKNKVPGTPRRIITLNLIVTPEYLRKMTTDHPDVIIYALRLDRGLSPPEVFGTEPGALWEKERGLDDRQYIVPGGGGFGEIMNNAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2A5</accession>
    <name>Q1D2A5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555039.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5064"/>
    <dbReference type="EnsemblBacteria" id="ABF90991">
        <property type="protein sequence ID" value="ABF90991"/>
        <property type="gene ID" value="MXAN_5064"/>
    </dbReference>
    <dbReference type="GeneID" id="41362348"/>
    <dbReference type="KEGG" id="mxa:MXAN_5064"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045796_0_0_7"/>
    <dbReference type="OMA" id="AHTIEYP"/>
    <dbReference type="OrthoDB" id="994146at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="37020" checksum="7640519FE12C49E0" modified="2006-07-11" version="1">MWALKNRTAYAAERNWTRDKEGVHWWLVAVKATFDIAPGGRLQLADEQPPPVLIPEYFGAPGQSSLRYDSDLLAVKPGTEVLLDGCAHAPRGKPAETVPVSLRLGPLHKVLLVHGPRTYSRGMLGMAVSRPQPFTTSPIRYEAAFGGYDTTDSDPSKHRIDERNPVGRGFATRQAQLTGKPAHTIEYPSGEPATRGPAGFGPIDAAWMPRRKLAGTYDARWERTKKPLLPDDYDPTFALSAPGDQRLDGPLTGGERVELMNMTPEGVLRFELPRISLGFTTHVGRRSEEHGARLTTVLVEPEARRLSLVWQGTLCVPAPDADYLDETEIAELKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2E3</accession>
    <name>Q1D2E3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M75 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555001.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5025"/>
    <dbReference type="EnsemblBacteria" id="ABF90888">
        <property type="protein sequence ID" value="ABF90888"/>
        <property type="gene ID" value="MXAN_5025"/>
    </dbReference>
    <dbReference type="GeneID" id="41362310"/>
    <dbReference type="KEGG" id="mxa:MXAN_5025"/>
    <dbReference type="eggNOG" id="COG3489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044588_0_0_7"/>
    <dbReference type="OMA" id="RDNIYSW"/>
    <dbReference type="OrthoDB" id="510549at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14659">
        <property type="entry name" value="Imelysin-like_IPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034984">
        <property type="entry name" value="Imelysin-like_IPPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_M75" evidence="2">
        <location>
            <begin position="91"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="438" mass="46753" checksum="B424AAC037E057CF" modified="2006-07-11" version="1">METRTFPRQTLKLIVINNIGVLASPDMNTESSRPLSVLRARAIALAVPALLSLSACKSDKVTPPDAGTDNPGDTVAATRAALLESSGACVLQTAREFQTAATALESAVAAHAATPDATTRDTAREAYHQAMDVWQMAEVMQFGPAAPRSLPGGAEIRDNIYSWPLVSRCAIEEQLVNRSYESESFDSSLVSRRGLYALEYLLFFEGNDTACPGTSVIVSQGTWAALSADERAARKRAYAAVVAADVHRRADALVNAWAPDQENFGRTLTTAGSGNAVYPSTQAALNSVSDAIFYFEREVKDLKVARPLALRDCATSTCPEHLESQFAARSKANIRANLVGYRRITEGCGENFSGTGFDDLLEASGADALAAKLRERNAAAAAGIDAVPGEDLATVLAQDKAAMRTMYDVIKSVTDVLKTELVTVLDLELPQSVEGDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2X7</accession>
    <name>Q1D2X7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554821.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91648">
        <property type="protein sequence ID" value="ABF91648"/>
        <property type="gene ID" value="MXAN_4835"/>
    </dbReference>
    <dbReference type="GeneID" id="41362131"/>
    <dbReference type="KEGG" id="mxa:MXAN_4835"/>
    <dbReference type="eggNOG" id="ENOG5031CRN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1413836_0_0_7"/>
    <dbReference type="OrthoDB" id="1796338at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="17732" checksum="4CAAB0D72DAABAC3" modified="2006-07-11" version="1">MSVGGAGGSNGSRGSNGASNAGRSAAAGAANAAGKAAGGIAGALGGIGKALGGIGKAVGGLANSIGGIAGKIGSALSQVSGLVDKAMSAITGPLKSMIGGLLDKMPFGIGQLAKPFVDKFIDNGLAMVAGGPLGGVASMFGKAGTVGKLADMVETVRTGAKTVGDIAEGRFNAQQMAAFAQAQLMRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Y2</accession>
    <name>Q1D2Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoquinoline 1-oxidoreductase, alpha subunit</fullName>
            <ecNumber evidence="3">1.3.99.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorA</name>
        <name evidence="3" type="ORF">MXAN_4830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.16" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554816.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4830"/>
    <dbReference type="EnsemblBacteria" id="ABF91771">
        <property type="protein sequence ID" value="ABF91771"/>
        <property type="gene ID" value="MXAN_4830"/>
    </dbReference>
    <dbReference type="GeneID" id="41362127"/>
    <dbReference type="KEGG" id="mxa:MXAN_4830"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_0_7"/>
    <dbReference type="OMA" id="IIHYLTG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047121">
        <property type="term" value="F:isoquinoline 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16408" checksum="A57FB20FA751584E" modified="2006-07-11" version="1">MTVRVRINGEEKELDVDPEMPLLWAVRDVLGLTGTKYGCGQALCGSCTVHLDGQPVRACVTPIRRAEGHSVTTIEGLSPDGNHPLQKAWVELGVPQCGFCQTGQIMCAAALLAKKPQPSDKEIDQSLAGNLCRCGTYTRIRSAVKKAAGMSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z5</accession>
    <name>Q1D2Z5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4817"/>
    <dbReference type="CAZy" id="CBM61">
        <property type="family name" value="Carbohydrate-Binding Module Family 61"/>
    </dbReference>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93028">
        <property type="protein sequence ID" value="ABF93028"/>
        <property type="gene ID" value="MXAN_4817"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4817"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606520_0_0_7"/>
    <dbReference type="OMA" id="KTMEVEW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187834" evidence="1">
        <location>
            <begin position="19"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="59"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="50136" checksum="6EC2C5B472821788" modified="2006-07-11" version="1">MHKRHALRSMLWAASSLALVGGCSPEPELSDAEALPLVTQEQGERAYDPGPGWNLAWQDDFTGNSLNSANWTVLTSNFDPVTNNCNFGTGELEFPRAQNVTVAGGKLILTAQRTADAPFDSRCAGYGPRSYYSGRIHSKGKVERRYGKLVASIKVPSGYGMWPAFWTLGANISNVGWPRSGEIDILEWHSNDASWMKSAAHWFANGAQQSWGTGANRGYSIADGFHTYEVEWTANRMIFRLDGEIRGNEFAHNEAAFQQNHYILLNLALGGNWYGHPHPDAIGLPWGQTKTMEVEWVRWYQPGSTPPPASLTNASFENGMTGWATWSPNGTEAADFSETYNGGRTGAYHLTHWTNGTPFEVWTYQPVPGLASGTYKVRAWVRKSGGFDLSRLQAKTCGECAPVFTNLGNHGDWTMVETPPISVTGGYLELGFHTRATSGNSANFIHMDDVELIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3J5</accession>
    <name>Q1D3J5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3 7">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbC</name>
        <name evidence="8" type="ORF">MXAN_4610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554605.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4610"/>
    <dbReference type="EnsemblBacteria" id="ABF88609">
        <property type="protein sequence ID" value="ABF88609"/>
        <property type="gene ID" value="MXAN_4610"/>
    </dbReference>
    <dbReference type="GeneID" id="41361910"/>
    <dbReference type="KEGG" id="mxa:MXAN_4610"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_7"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="20266" checksum="C74B46EF86959DE3" modified="2006-07-11" version="1">MKVTPLEIPDVLLLEPKVFGDDRGFFMEMFHAARYAAVGIPGPFVQDNYSRSAKGTLRGVHFQEPQAQGKLVQVLAGAVYDVAVDVRRGSPTFGQWVAVELSSDNRRQLWIPPGFAHGFCVVSDSADFHYKCTALYAPETERSVVWNDPDLAIPWPVSEPLLSPKDAQAPRLRDAPLLPEYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3R9</accession>
    <name>Q1D3R9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4536"/>
    <dbReference type="EnsemblBacteria" id="ABF93067">
        <property type="protein sequence ID" value="ABF93067"/>
        <property type="gene ID" value="MXAN_4536"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4536"/>
    <dbReference type="HOGENOM" id="CLU_2012808_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="123" mass="13226" checksum="20C831CCE4ADCAA5" modified="2006-07-11" version="1">MDATGAGHCLAFIIGCQGVDDLDVSKHSDQDPLVDREALSDRDGLPGKRSANGTSAEGQPVKLFQRATQLVREVSGGDAFNRAVTLERMAKHPGFLRAPPGRSLKPIRIRHRKPPFQSAPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3S0</accession>
    <name>Q1D3S0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554530.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86454">
        <property type="protein sequence ID" value="ABF86454"/>
        <property type="gene ID" value="MXAN_4535"/>
    </dbReference>
    <dbReference type="GeneID" id="41361837"/>
    <dbReference type="KEGG" id="mxa:MXAN_4535"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120501_0_0_7"/>
    <dbReference type="OMA" id="CTEDEAY"/>
    <dbReference type="OrthoDB" id="1942677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22671" checksum="ADAA2DD1BE30C032" modified="2006-07-11" version="1">MGIPTRDEDVALHARILQRESVANVDAFAVFVDPIIAAVKYARGCTHEMARDAAIDVLLDYLEAPERFDPQRGRLFSYLAQSAKNTVTDWQRSATRRQAREEKFGLLFELLGRSPKDCLEQSAEVKCIVERIEQSDLSQVDRAFLGLMLQGERSTQRFAEVLGLGALPAVDIQREVKRNRDRIMKWLVRFGREVFGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z8</accession>
    <name>Q1D3Z8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribosome association toxin RatA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554452.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4454"/>
    <dbReference type="EnsemblBacteria" id="ABF89387">
        <property type="protein sequence ID" value="ABF89387"/>
        <property type="gene ID" value="MXAN_4454"/>
    </dbReference>
    <dbReference type="GeneID" id="41361765"/>
    <dbReference type="KEGG" id="mxa:MXAN_4454"/>
    <dbReference type="eggNOG" id="COG2867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1823279_0_0_7"/>
    <dbReference type="OMA" id="KDNKGSW"/>
    <dbReference type="OrthoDB" id="1691158at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="16008" checksum="53B60B2C850F85F6" modified="2006-07-11" version="1">MPGASRTIIVNAPIEKVFDVITQYERYPEFLPEVKGIRTENRKGNTVDVHYKVDVVKTINYSIHVTEERPTRMSWTYIKGEFMKDNQGSWVLVPEGEGKTKATYTVEMALGALVPKSVVSALVETSLPKMLDAFKRRFEAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D406</accession>
    <name>LEXA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LexA repressor</fullName>
            <ecNumber evidence="1">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lexA</name>
        <name type="ordered locus">MXAN_4446</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554445.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D406"/>
    <dbReference type="SMR" id="Q1D406"/>
    <dbReference type="STRING" id="246197.MXAN_4446"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="ABF92162">
        <property type="protein sequence ID" value="ABF92162"/>
        <property type="gene ID" value="MXAN_4446"/>
    </dbReference>
    <dbReference type="GeneID" id="41361758"/>
    <dbReference type="KEGG" id="mxa:MXAN_4446"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_1_7"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CollecTF" id="EXPREG_00000d50"/>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001217">
        <property type="term" value="F:DNA-binding transcription repressor activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000269"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000001307" description="LexA repressor">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <sequence length="222" mass="24712" checksum="47F78D2E2654DA2C" modified="2006-07-11" version="1">MEELTERQREILSFIVKETETRGFPPTIREIGEHMDIRSTNGVNDHLKALERKGYLNRGEQQSRSLVATKRARLLLGLGARKDSGMVEIPLLGKVAAGAPLLAQENMEDSVKIDSFLLGGVNGREVFALRVKGQSMIDDGIHDGDYLFVKKTPSAQPGEIVVALIEDEATVKRYYPEGDRIRFQPANATMQPIYVSRAEFRSTMILGQVVGVYRKLQGGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4G5</accession>
    <name>Q1D4G5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4283"/>
    <dbReference type="EnsemblBacteria" id="ABF86656">
        <property type="protein sequence ID" value="ABF86656"/>
        <property type="gene ID" value="MXAN_4283"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4283"/>
    <dbReference type="HOGENOM" id="CLU_2899468_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="62" mass="6745" checksum="F06DDB0D4798365B" modified="2006-07-11" version="1">MEGLQGNAVRHDPECLVPDGRMALVGVLHVDRGVLQQVNSRICSKVAWSRRNAKMGCVTLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D523</accession>
    <name>Q1D523_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554079.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D523">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4072"/>
    <dbReference type="EnsemblBacteria" id="ABF86598">
        <property type="protein sequence ID" value="ABF86598"/>
        <property type="gene ID" value="MXAN_4072"/>
    </dbReference>
    <dbReference type="GeneID" id="41361402"/>
    <dbReference type="KEGG" id="mxa:MXAN_4072"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_7"/>
    <dbReference type="OMA" id="EFEIFRL"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="177"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF86598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="27038" checksum="119F1DB03FAF173E" modified="2006-07-11" version="1">MTGAPVDAPQPPDSPPIRVFVVEDQTKILKNQLRLFENHPEMDIIGTALSGEAALEEVPKLMPDVLLLDLGLPRMSGIDVTREVKARFPKIEILIFTIFDEEDKVLEAVKAGASGYLLKGAPVDKIIEAIKEVRAGGTVIQPNLARRLLRHFRVEPDASPLISPPAAPEPSASDLPQEPLLKPLSDREREILQLIAKGVSNSEAARLLDLSKATIRTHLEHIYRKLEVTNRVEAVTEGIRKGLISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5J0</accession>
    <name>Q1D5J0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux transporter, AcrB/AcrD/AcrF family, inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
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                <person name="Sullivan S.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
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</entry>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="787" mass="86466" checksum="C313251A4032BA8A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D660</accession>
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            <fullName evidence="2">FTP domain-containing protein</fullName>
        </recommendedName>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012703_2_0_7"/>
    <dbReference type="OMA" id="WALIEAH"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FTP" evidence="2">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="697" mass="74614" checksum="0D1B5AB81ECA8BF3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D685</accession>
    <name>Q1D685_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3651"/>
    <dbReference type="EnsemblBacteria" id="ABF91452">
        <property type="protein sequence ID" value="ABF91452"/>
        <property type="gene ID" value="MXAN_3651"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3651"/>
    <dbReference type="eggNOG" id="COG2323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1729424_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF91452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16787" checksum="B68067D96C19B3A8" modified="2006-07-11" version="1">MVSPRASAPAPIILERVLARSGCPGDVWVRAPTPTGGGARGQHSNMKPIDWHGLWVPDLHPFEVIIRVSLVFLFVQFVLRLVGRKELSRYVSFDLALVHGNLRKTRISHKELLSHLRAHGRGDLSAVHAAFLEPNGKVTFLFREEGSATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D689</accession>
    <name>Q1D689_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553665.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3647"/>
    <dbReference type="EnsemblBacteria" id="ABF88980">
        <property type="protein sequence ID" value="ABF88980"/>
        <property type="gene ID" value="MXAN_3647"/>
    </dbReference>
    <dbReference type="GeneID" id="41360984"/>
    <dbReference type="KEGG" id="mxa:MXAN_3647"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_7"/>
    <dbReference type="OMA" id="LTTHIAC"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04316">
        <property type="entry name" value="dhbA_paeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="257" mass="26589" checksum="117B9B2E8E322B74" modified="2006-07-11" version="1">MGTPTRVALVTGAAQGIGAAVARALAGEALIAAVDTNADGLSALVAELRQKHQHAVAYPASVSDVAAVDAVVERIERELGPIEVLANVAGVLRTGPILSYSDEDWAFTFSVNTLGVFQVSRAVARRMVPRRSGVIVTVGSNAAAVPRTQMAAYAASKAASSMFTKCLGLELAPHGIRCNVVSPGSTDTAMQRALWADDSGAQAVIAGSPEAYRLGIPLQRIATPEDIANAVRFLVSDAARHITLHDLRVDGGATLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6P0</accession>
    <name>Q1D6P0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative antibiotic biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553519.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3488"/>
    <dbReference type="EnsemblBacteria" id="ABF92132">
        <property type="protein sequence ID" value="ABF92132"/>
        <property type="gene ID" value="MXAN_3488"/>
    </dbReference>
    <dbReference type="GeneID" id="41360835"/>
    <dbReference type="KEGG" id="mxa:MXAN_3488"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516704_0_0_7"/>
    <dbReference type="OMA" id="PKMLGGP"/>
    <dbReference type="OrthoDB" id="180842at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041141">
        <property type="entry name" value="CmlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18456">
        <property type="entry name" value="CmlA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CmlA_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="268"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="59828" checksum="85A5592D8239757D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6R6</accession>
    <name>Q1D6R6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, Gfo/Idh/MocA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553493.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3460"/>
    <dbReference type="EnsemblBacteria" id="ABF86536">
        <property type="protein sequence ID" value="ABF86536"/>
        <property type="gene ID" value="MXAN_3460"/>
    </dbReference>
    <dbReference type="GeneID" id="41360807"/>
    <dbReference type="KEGG" id="mxa:MXAN_3460"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_1_7"/>
    <dbReference type="OMA" id="ISYAHPH"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008354">
        <property type="entry name" value="Glc-Fru_OxRdtase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01775">
        <property type="entry name" value="GLFROXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="163"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="42768" checksum="C5F0059ADFD4381F" modified="2006-07-11" version="1">MAGASGAQRVSHTRRQSMAQGSSRRIRYAVVGAGNIAQVAVLPAFQHALENSELVALFSSDAEKRDVLGKMYGVRHTASYDDLEQVLRDADVDAVYIALPNTQHRAFTERAARAGVHVLCEKPMATSVEDCEAMIRVTDENHVKLMIAYRLHFEEANLRAIDLLRSGRLGEPLMMSALLTQQVRTGDIRTRVDVGGGALLDEGPYPINAARYLFRDEPTEVFCYTNEEQDPRFKGVDATAFALMRFSNGRIAQFGISHAASAVSSYRVVGEKGDLLVESAFGYEKERKHVLTLEGKTEERVFATHDQFAPELLYFSKCVLEDQEPGPSGREGLADVRVITAMQESARTGRPVKLEAFPMKRRPSLDQLIVRPAARPPAPVNAPAPVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7J7</accession>
    <name>Q1D7J7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553222.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3173"/>
    <dbReference type="EnsemblBacteria" id="ABF91364">
        <property type="protein sequence ID" value="ABF91364"/>
        <property type="gene ID" value="MXAN_3173"/>
    </dbReference>
    <dbReference type="GeneID" id="41360531"/>
    <dbReference type="KEGG" id="mxa:MXAN_3173"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082944_0_0_7"/>
    <dbReference type="OMA" id="IAMQEMD"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="307" mass="33174" checksum="56E6D8FEAAE820F1" modified="2006-07-11" version="1">MHGSLKCNNARDAAAEAPGAREGVWQPGYLQRLRIAPPWALLLLTFLTGCPLAENYTDEAGPRYSGDHRKPDTVSSEAPASITVVTFNLSFAEKVTEAITALSRPPLAGADVIAMQEMDAASVDRIASELGLAYVYYPASVQVDDDDFGNALLSRWPIVADRKVHLPHDDPYHQRRRIAVLATLDIGGTLVQTASVHNATPIVGLGGRLDQAETIIDAMEGTGPVQVIAGDFNTSDPGSLRQMVKLFSERDFQWASEGVGDTVDSVIGGLPLDFVFAQGLAPLERGVDRRPAGSDHHPVWVRFAWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7N0</accession>
    <name>Q1D7N0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553190.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87291">
        <property type="protein sequence ID" value="ABF87291"/>
        <property type="gene ID" value="MXAN_3140"/>
    </dbReference>
    <dbReference type="GeneID" id="41360499"/>
    <dbReference type="KEGG" id="mxa:MXAN_3140"/>
    <dbReference type="HOGENOM" id="CLU_1037560_0_0_7"/>
    <dbReference type="OMA" id="PRSTSCE"/>
    <dbReference type="OrthoDB" id="1753169at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188336" evidence="1">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="28784" checksum="A982D4ED48F11909" modified="2006-07-11" version="1">MRRLVFLAVMAPLLVACATTHQVVPRSTSCEKGSLWACNEWGEQLLQDGDRSQAETAFSKACDGGSTRGCLALGRLRMADGNLAGAEAPFVTVYETDSEEGALALADLYDARGGEAHARAAARLRREAPALDKPAFDFAMQYRVGAWRPTADLALNIQPMAFLERRLNIGSNLAYTSRGISEFNGFVGYQHFVNAWVVPYGRLMMGTATRASRDPGFNVGAEVGTRLALGYFGHVNVAAGMSRASGNYMSVGVGLNGLFVLLMLLHAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D898</accession>
    <name>PUR9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="1">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">IMP cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">purH</name>
        <name type="ordered locus">MXAN_2914</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="1"/>
    <dbReference type="EC" id="3.5.4.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552974.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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        <property type="gene ID" value="MXAN_2914"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
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        <property type="entry name" value="MGS-like_dom"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000018916" description="Bifunctional purine biosynthesis protein PurH">
        <location>
            <begin position="1"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <sequence length="514" mass="54953" checksum="CE89D55F723A1984" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P6</accession>
    <name>Q1D8P6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M28E family</fullName>
            <ecNumber evidence="3">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.-" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF90177">
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        <property type="gene ID" value="MXAN_2760"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2760"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188495" evidence="1">
        <location>
            <begin position="21"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="198"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="680" mass="71457" checksum="2867B4F53A473535" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8Q6</accession>
    <name>Q1D8Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2750</name>
    </gene>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2750"/>
    <dbReference type="EnsemblBacteria" id="ABF92848">
        <property type="protein sequence ID" value="ABF92848"/>
        <property type="gene ID" value="MXAN_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2750"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129722_1_0_7"/>
    <dbReference type="OMA" id="DQSCVKI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="16310" checksum="D040A8664874512E" modified="2006-07-11" version="1">MMAQLRAQRAPSAGPEGTATSASAEVRATTYLVRTEADASHARLAARMLCESLGGRGYECQKVATAVSELARNQISYAGGGTIQLAPQLAPKRLLRVSAEDSGQGIPDLERVLSGTYKSKTGMGLGLLGVKRLADRFDVRTGPTGTQVDFEVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8T3</accession>
    <name>Q1D8T3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552790.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2723"/>
    <dbReference type="EnsemblBacteria" id="ABF91031">
        <property type="protein sequence ID" value="ABF91031"/>
        <property type="gene ID" value="MXAN_2723"/>
    </dbReference>
    <dbReference type="GeneID" id="41360101"/>
    <dbReference type="KEGG" id="mxa:MXAN_2723"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_85_1_7"/>
    <dbReference type="OMA" id="HAHLACE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="581"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="843" mass="91192" checksum="A155407D7DCB6D98" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8T6</accession>
    <name>Q1D8T6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552787.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2720"/>
    <dbReference type="EnsemblBacteria" id="ABF91675">
        <property type="protein sequence ID" value="ABF91675"/>
        <property type="gene ID" value="MXAN_2720"/>
    </dbReference>
    <dbReference type="GeneID" id="41360098"/>
    <dbReference type="KEGG" id="mxa:MXAN_2720"/>
    <dbReference type="HOGENOM" id="CLU_2398185_0_0_7"/>
    <dbReference type="OMA" id="HSGQEYL"/>
    <dbReference type="OrthoDB" id="2084634at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="99" mass="10466" checksum="7F4C0E593A7552C3" modified="2006-07-11" version="1">MVNFNNLKKLDKDDLLHLVGLETRRDTVDTLLPVVGAFAAGILVGAGLGLLLAPKSGNQLRDDLRQRLHSGQEYLSNAVGRSSEGAAQTGPQGTVSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8T7</accession>
    <name>Q1D8T7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552786.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2719"/>
    <dbReference type="EnsemblBacteria" id="ABF91916">
        <property type="protein sequence ID" value="ABF91916"/>
        <property type="gene ID" value="MXAN_2719"/>
    </dbReference>
    <dbReference type="GeneID" id="41360097"/>
    <dbReference type="KEGG" id="mxa:MXAN_2719"/>
    <dbReference type="HOGENOM" id="CLU_1988864_0_0_7"/>
    <dbReference type="OMA" id="PYGMMAA"/>
    <dbReference type="OrthoDB" id="1838356at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="144" mass="14701" checksum="313993F0561CBAFE" modified="2006-07-11" version="1">MTTFPGASGNGTPQDPQGGGFGQRVDHIGSDAQQLWSDARGAVTDLGQTLDLRGRVERNPYGMMAAAVGVGYLLGGGLFTPLTARILRLGVRLAALPLVKDELLGMAESAFQGYQTGRGMAGPGPQGSAAANATSAGTPRPPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D962</accession>
    <name>Q1D962_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552662.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2592"/>
    <dbReference type="EnsemblBacteria" id="ABF89035">
        <property type="protein sequence ID" value="ABF89035"/>
        <property type="gene ID" value="MXAN_2592"/>
    </dbReference>
    <dbReference type="GeneID" id="41359970"/>
    <dbReference type="KEGG" id="mxa:MXAN_2592"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_6_7"/>
    <dbReference type="OMA" id="AFHHAVN"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="273" mass="30174" checksum="B224C721757F6ADB" modified="2006-07-11" version="1">MASSPLPFLRGLRPTLHIAHRGGAAVAPENTLAAFRQAVERYRTDMLELDLHLTRDGELVVAHDATLERCTDGTGPLAALTLAELQRLDAGFHFTPDEGRTLPFRGQGVRIPSFRELLRAFPNLRLNVELKPDVPGIEDTFAQVLQEEGALERVCMGSELDTVAERLAERLPSACHFYPRDALAAFVIALRGGDTPPEDPRYTVLDMPLYFGEIRLVDSDFLQQCAARGKWVNVWTVDDPAEMHQLLAEGVGGIMTDRPDVLRQIMDAPSKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D976</accession>
    <name>Q1D976_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase, RsmB/NOP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_2578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552648.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2578"/>
    <dbReference type="EnsemblBacteria" id="ABF90579">
        <property type="protein sequence ID" value="ABF90579"/>
        <property type="gene ID" value="MXAN_2578"/>
    </dbReference>
    <dbReference type="GeneID" id="41359956"/>
    <dbReference type="KEGG" id="mxa:MXAN_2578"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_2_7"/>
    <dbReference type="OMA" id="NPELRWR"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="191"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="472" mass="51741" checksum="7234EAD7964677F2" modified="2006-07-11" version="1">MATQRKSRPHSRSAPKKSGAPSGKKPSPSERPERPLREDLVLQACLEAYGSVRHEGRMADRALDFTLRRKANLYSNERRAVAERVYGLLRRQRTVDFLLSRAHPRFDSLETSRQDVLRLAASRVLYGEPHGLVARQSALAPPDAQALGALPEAAAALEALPARERFPIAASLPDFLADRFLQTFGRDAARAAEAMNERAPLVARANLLKGDRDALAQRLKAETVDVKPTPLSPMGLVLETRINAFSLESFREGMLELQDEGSQLLGMLVDAPPTRVVDACAGAGGKTLQLAAQMKNRGDLHALDIDERRMEDLKKRARRAGVHNVRAQLIPHEGPEADAALTPLKGKADRVLVDAPCSGTGTFRRKPDARYRLTPEDLEMHVGRQKALLARFATLVKPGGRLIYGTCSVLREENENVVEDFLAKHPEFTVKPVAELLGAELAEKVGPGPFLRLAPHTHGTDGFFGAVLVRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9G5</accession>
    <name>Q1D9G5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552560.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2489"/>
    <dbReference type="EnsemblBacteria" id="ABF90397">
        <property type="protein sequence ID" value="ABF90397"/>
        <property type="gene ID" value="MXAN_2489"/>
    </dbReference>
    <dbReference type="GeneID" id="41359869"/>
    <dbReference type="KEGG" id="mxa:MXAN_2489"/>
    <dbReference type="eggNOG" id="ENOG5032S5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130420_0_0_7"/>
    <dbReference type="OMA" id="HYKYASG"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="145" mass="15281" checksum="E28BB69502B29DA1" modified="2006-07-11" version="1">MGAMPTTWTDADPLAFLANVTPAGRRRDAQVLLDLMREVTGLEPKMFGPSIVGFGEYAYQYASGHRGTAPAAGFSPRKAATVVYLADGLSAHASALAKLGPHTTGTGCLYIKDLTKVDLDVLTGIVRASLKTLTAGTYGKRAHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Q6</accession>
    <name>Q1D9Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YcaO-like fatty acid binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552472.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2397"/>
    <dbReference type="EnsemblBacteria" id="ABF92975">
        <property type="protein sequence ID" value="ABF92975"/>
        <property type="gene ID" value="MXAN_2397"/>
    </dbReference>
    <dbReference type="GeneID" id="41359781"/>
    <dbReference type="KEGG" id="mxa:MXAN_2397"/>
    <dbReference type="eggNOG" id="COG1944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056369_0_0_7"/>
    <dbReference type="OMA" id="TWTSNGM"/>
    <dbReference type="OrthoDB" id="735222at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="55"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="387" mass="40790" checksum="C6381BAF3FAA526F" modified="2006-07-11" version="1">MRAPRDELSSRRFQQRLAQAMGVTRVARVTGLDRTGVEVACAVRPGGHILQVCNGKGLSYDDAAWGALLETAELWAAETVVPDALVWGSRAELDGHLGALWGADELGSAGALVAPRLWSPHVRCAWLEARELYSGEPVWVPAQGLHVPPAGSPALGPVAVAWTSNGSGAHPDAGRALLHALLEATERDQLARMMPEGWTEEVVQRRLLRTPELLELAPAVEALAGPLRERGFGVYLFDATPAARTPGAVGLPVGAAVLVDLEEGPVPLTAGYACALTREAALLKALLEAAQSRLTDIHGAREDVAAADREAARGFAEACAQVRPRRRAADMPDLGAKGAAAGQVRQVLAKLQRAGFTRAAAVAMSSPVEGLHVQKVVVPGMRISELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9V9</accession>
    <name>Q1D9V9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552419.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF85843">
        <property type="protein sequence ID" value="ABF85843"/>
        <property type="gene ID" value="MXAN_2344"/>
    </dbReference>
    <dbReference type="GeneID" id="41359729"/>
    <dbReference type="KEGG" id="mxa:MXAN_2344"/>
    <dbReference type="eggNOG" id="ENOG50340QF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760369_0_0_7"/>
    <dbReference type="OMA" id="FCKYVAG"/>
    <dbReference type="OrthoDB" id="496640at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="364" mass="40810" checksum="A5469C0A9F521B4C" modified="2006-07-11" version="1">MPRLLDSLPLLYRDLLPDFFRQDVPEESKATCSNCAMSQDSAQGAVDSVDGVSRMFRPDTKCCTYSPRLPNYLVGALLSDDRPELAEGRRRMEAKIASRVGVTPQWVKPPAKFQLLYKNGHQFFGRAASLRCGYFSADSGGCTIWPYREAVCSTFFCKYVAGADGRKFWMSLKTYLTLAEIQLSRWTALQLLPDYVLTGRDRAETQPGPLTVEDLDDTAPPAKAYAALWQGYEGLELDYFRECYRMVKALPPDGVEKLLGLDGTIELKTLEKLHHTAVAPQLPRTLKLNPDATVQWMQDGSVALGAYSEYDAVALPGEAYGLLVDFTGREPVDAVRKHLREHKQADLSEDVLLELYRHRILVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9X5</accession>
    <name>Q1D9X5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552403.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2327"/>
    <dbReference type="EnsemblBacteria" id="ABF92678">
        <property type="protein sequence ID" value="ABF92678"/>
        <property type="gene ID" value="MXAN_2327"/>
    </dbReference>
    <dbReference type="GeneID" id="41359714"/>
    <dbReference type="KEGG" id="mxa:MXAN_2327"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514509_0_0_7"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011464">
        <property type="entry name" value="DUF1570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07607">
        <property type="entry name" value="DUF1570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188318" description="DUF1570 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1570" evidence="2">
        <location>
            <begin position="156"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="524" mass="58629" checksum="A67AEB5975F1F940" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA34</accession>
    <name>Q1DA34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552344.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2268"/>
    <dbReference type="EnsemblBacteria" id="ABF88547">
        <property type="protein sequence ID" value="ABF88547"/>
        <property type="gene ID" value="MXAN_2268"/>
    </dbReference>
    <dbReference type="GeneID" id="41359656"/>
    <dbReference type="KEGG" id="mxa:MXAN_2268"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="RVIEANC"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03434">
        <property type="entry name" value="ADOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="305"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="458"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="715"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="809" mass="84631" checksum="C48D32E5B4859689" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA35</accession>
    <name>Q1DA35_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, 2-nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552343.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2267"/>
    <dbReference type="EnsemblBacteria" id="ABF91122">
        <property type="protein sequence ID" value="ABF91122"/>
        <property type="gene ID" value="MXAN_2267"/>
    </dbReference>
    <dbReference type="GeneID" id="41359655"/>
    <dbReference type="KEGG" id="mxa:MXAN_2267"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_5_1_7"/>
    <dbReference type="OMA" id="MDNARPF"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="357" mass="38314" checksum="114FAEBB0D288B50" modified="2006-07-11" version="1">MSPHRTNEALQKLGIQHPIIQGPFGGGLSTERLAAAVSNLGGLGSYGAYQLPPEELGRVADRIRALTDKPFALNLWVSDHDAGGDALSPEDFDRVYRLFEPYYRELGVEKPAMPERFHHRFEDQVEALLEARPPIFSFVFGVPPASVLAECRRKGILTAGAATTLAEAEALDAAGVDLIVATGFEAGGHRPSFLARAEDSLMGTLALTPLVADRVKVPVIAAGGIADGRGIRAALTLGAQAAQLGTAFLACEESGTTDAHRELLFSDRAKHTTLTRSFTGRLARGMRNRWTEEVAHQLSALAPFPIQGWFLSKLKPAAVKAGRTDLVSLWAGQATPNLRHRTVPALMDSLIKELSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA78</accession>
    <name>Q1DA78_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2224"/>
    <dbReference type="EnsemblBacteria" id="ABF87950">
        <property type="protein sequence ID" value="ABF87950"/>
        <property type="gene ID" value="MXAN_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2224"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095331_0_0_7"/>
    <dbReference type="OMA" id="TIPILPC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="30965" checksum="555505313F25AC8D" modified="2006-07-11" version="1">MPPATSLVYHRAMPTHETKATAISGKETTVPLLPCVSADETLAFYQALGFTVTYQMTKPYLYLALRWSDIELHFGKGAKSLDPSEENSGGCLVMVDSVEPYHRAFTDALRAKYGKVLATGRPRITRFRPGQSRFSLIDPTGNNIIFIQRDEPEDLEYGGSAKLTGLAKAIDNARILREFKNDDKAAARALDIGLARYEAEAPVVDRVRALAARMELAIALGDATTGRALKQQLQAVPLPEEARSQLSDELKAAERLEDWLARTRPDPAPSQRTGSPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAA6</accession>
    <name>Q1DAA6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF86639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2194"/>
    <dbReference type="EnsemblBacteria" id="ABF86639">
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        <property type="gene ID" value="MXAN_2194"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2194"/>
    <dbReference type="eggNOG" id="ENOG502ZQ5N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079027_0_0_7"/>
    <dbReference type="OMA" id="SREVWVT"/>
    <dbReference type="OrthoDB" id="1796395at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="249" mass="27879" checksum="C482FF8C5EA9B72F" modified="2006-07-11" version="1">MFSAFSRTLRTFTATTALLALTGCGEDTQDPLPGPPEELACDSQTYAEAVRNAAEPTVADISTELWAISPSNPRLIWNESRTAVRMAIWTTFAGYTLGENTLSREVWVTPAPQLQTFCKTVPEEKLVGRLNQYLGLPPPTENDNARYVVELWVRPENLFRPCPDAEIDDASCGLQFPASATSEHRNWINAYYAYSYGFWQSTHYPWTGLGYTYDWCNADTRVGASEYVVRADSIVEVTGKFERAIYCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK4</accession>
    <name>Q1DAK4_MYXXD</name>
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        <submittedName>
            <fullName evidence="8">OmpA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2090"/>
    <dbReference type="EnsemblBacteria" id="ABF88406">
        <property type="protein sequence ID" value="ABF88406"/>
        <property type="gene ID" value="MXAN_2090"/>
    </dbReference>
    <dbReference type="GeneID" id="41359497"/>
    <dbReference type="KEGG" id="mxa:MXAN_2090"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020578_0_0_7"/>
    <dbReference type="OMA" id="PENNGCP"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
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    </dbReference>
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        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188082" evidence="6">
        <location>
            <begin position="28"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="332"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
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        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
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        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="639" mass="68769" checksum="3F9D8CAD6F2F622D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAM7</accession>
    <name>Q1DAM7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2067"/>
    <dbReference type="EnsemblBacteria" id="ABF86099">
        <property type="protein sequence ID" value="ABF86099"/>
        <property type="gene ID" value="MXAN_2067"/>
    </dbReference>
    <dbReference type="GeneID" id="41364702"/>
    <dbReference type="KEGG" id="mxa:MXAN_2067"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147970_0_2_7"/>
    <dbReference type="OMA" id="LGQAWEQ"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="111" mass="11636" checksum="E9F4D4956966D5CF" modified="2006-07-11" version="1">MRRPAGRPRPEVQNAGSGPVRTCVGCGSRRQQAELTRFVIGPGGAIEVDRKRRLPGRGAYLCGAGCLTAALKRKAFGRAFRGKAGQVDPSQLGQAWEQGDGERRGAGGSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAQ6</accession>
    <name>Q1DAQ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2037"/>
    <dbReference type="EnsemblBacteria" id="ABF91092">
        <property type="protein sequence ID" value="ABF91092"/>
        <property type="gene ID" value="MXAN_2037"/>
    </dbReference>
    <dbReference type="GeneID" id="41359447"/>
    <dbReference type="KEGG" id="mxa:MXAN_2037"/>
    <dbReference type="eggNOG" id="COG4104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060321_0_0_7"/>
    <dbReference type="OrthoDB" id="701321at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="35001" checksum="8BC9DF0B149F955A" modified="2006-07-11" version="1">MNPIERGRKLINTVRTGAEKAIDRTQDAVGNAVDNVKDAAAAGGRKVGQFVDGFENAVSGTARGVGNVVGGAARGVQEFFGGGNQPDRVHDGKLLGADGATFPPGTPLADIPGVTPANNPNPQSTILYVNGILTTKEAQSESLQAIANATGSRVVGIHNATEGMGADLAQSVKDKLDKGTNPAVDTLADALYTEIKAGRDVHLMAHSQGGLVSSRALNDVYNRLRIEDGMSKQDAKALMGKINVETFGGAAATYPDGPNYVHYVNRGDPVPSMFGLGPIPDKWNPIADGGKGSKVHQFNEFHLNPFDGHSFEDVYLKNRVPFDQAREGNFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT9</accession>
    <name>Q1DAT9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552089.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1999"/>
    <dbReference type="EnsemblBacteria" id="ABF93153">
        <property type="protein sequence ID" value="ABF93153"/>
        <property type="gene ID" value="MXAN_1999"/>
    </dbReference>
    <dbReference type="GeneID" id="41359409"/>
    <dbReference type="KEGG" id="mxa:MXAN_1999"/>
    <dbReference type="HOGENOM" id="CLU_1184024_0_0_7"/>
    <dbReference type="OMA" id="VTEHWRL"/>
    <dbReference type="OrthoDB" id="1299806at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="234" mass="25055" checksum="A4BDE6F53D62E330" modified="2006-07-11" version="1">MRTTQDWSRFGGGVIVILALGATLALFVPRFLGAAAGPELEIITALKATESSGLSLPVPGAPGPLTSRQHRFARITVNVAPGGQRAEAQATLDFEGALGDTRVGTAGVERVPFVVRNGSWVPETTAAPRLQAVVWALESRRRALQAADAESLGRLAGPGTPGVGGPEWEQLRQVRARGYQAEAWYVRLERDDAVVTEHWRLQGALPARPVDTRGQRQLSLSLSGDEFLFSPSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAX6</accession>
    <name>Q1DAX6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1962"/>
    <dbReference type="EnsemblBacteria" id="ABF91475">
        <property type="protein sequence ID" value="ABF91475"/>
        <property type="gene ID" value="MXAN_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1962"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2262119_0_0_7"/>
    <dbReference type="OMA" id="EAVPNIG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="103" mass="11612" checksum="2E5CE0239024D306" modified="2006-07-11" version="1">MPSGTSPRSRHTMTEQMAEEMLQLSSQLFEKMISQQQAKVLRLAREAVPNISPEEVRNSHDFPELKEHPTFEFEDGILSGLIAAQIALRAEIKGRLPLEPPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB01</accession>
    <name>Q1DB01_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552027.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1928"/>
    <dbReference type="EnsemblBacteria" id="ABF91555">
        <property type="protein sequence ID" value="ABF91555"/>
        <property type="gene ID" value="MXAN_1928"/>
    </dbReference>
    <dbReference type="GeneID" id="41359342"/>
    <dbReference type="KEGG" id="mxa:MXAN_1928"/>
    <dbReference type="eggNOG" id="COG4254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418501_0_0_7"/>
    <dbReference type="OMA" id="RNVVPEG"/>
    <dbReference type="OrthoDB" id="266255at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FecR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="656" mass="68335" checksum="D1379E84CC8C8BA0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB60</accession>
    <name>Q1DB60_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551969.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1867"/>
    <dbReference type="EnsemblBacteria" id="ABF92957">
        <property type="protein sequence ID" value="ABF92957"/>
        <property type="gene ID" value="MXAN_1867"/>
    </dbReference>
    <dbReference type="GeneID" id="41359283"/>
    <dbReference type="KEGG" id="mxa:MXAN_1867"/>
    <dbReference type="HOGENOM" id="CLU_2396588_0_0_7"/>
    <dbReference type="OMA" id="MCRKRGP"/>
    <dbReference type="OrthoDB" id="1802621at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="93" mass="10524" checksum="26FB2E5109D05F7E" modified="2006-07-11" version="1">MTPEQLQRAWVLQAQADAERGVLECRMCRRRGPLEETTTLWRNGLLVFALCDRCAASHDVVFSPTQAGVEVRARRRSPVDLATQEVPRVHGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBF3</accession>
    <name>Q1DBF3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LppY/LpqO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89564">
        <property type="protein sequence ID" value="ABF89564"/>
        <property type="gene ID" value="MXAN_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1770"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045679_1_0_7"/>
    <dbReference type="OMA" id="MGVNTWA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011094">
        <property type="entry name" value="Uncharacterised_LppY/LpqO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07485">
        <property type="entry name" value="DUF1529"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188376" evidence="1">
        <location>
            <begin position="25"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="33327" checksum="4AAF4C50B967625C" modified="2006-07-11" version="1">MLRSECWKCLALVVALLFTGAAHAQQRKGDQPKDVGIDTADIERRTGAKGELSADEGVFKVNLPRTDLKVGAAGVKLIPPLGLTAWAAFKRVGDATMVMGDIVLLEDQVNPVMDVALQNGLEVTALHNHFFWEQPKVMFMHISGMGETARLADAVGKVFTRLRETAGGKGRVPRASVDPARSKLDVTKLDALLGQKGTSKDGVYKVTVGRTVRIYGHEMGKAMGVNTWAAFAGTPQQAVVDGDFAILESELQPVLKALRAANIDIVAIHNHMTGEEPRMLFLHYWGVGPADALARGVRSAMELTLAPTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH1</accession>
    <name>Q1DBH1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoquinoline 1-oxidoreductase, beta subunit</fullName>
            <ecNumber evidence="2">1.3.99.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iorB</name>
        <name evidence="2" type="ORF">MXAN_1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551861.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1752"/>
    <dbReference type="EnsemblBacteria" id="ABF87205">
        <property type="protein sequence ID" value="ABF87205"/>
        <property type="gene ID" value="MXAN_1752"/>
    </dbReference>
    <dbReference type="GeneID" id="41359182"/>
    <dbReference type="KEGG" id="mxa:MXAN_1752"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013917_0_1_7"/>
    <dbReference type="OMA" id="LPRTEMG"/>
    <dbReference type="OrthoDB" id="337328at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047121">
        <property type="term" value="F:isoquinoline 1-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="214"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="718" mass="76926" checksum="E5F421AC818080A4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBK0</accession>
    <name>Q1DBK0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87453">
        <property type="protein sequence ID" value="ABF87453"/>
        <property type="gene ID" value="MXAN_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1722"/>
    <dbReference type="HOGENOM" id="CLU_3390400_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="32" mass="3779" checksum="6B70FA12B27E7C76" modified="2006-07-11" version="1">MRHLDTSAFVRNMRALAEFVTRTTTDCTAWNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBP6</accession>
    <name>Q1DBP6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551786.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1675"/>
    <dbReference type="EnsemblBacteria" id="ABF90627">
        <property type="protein sequence ID" value="ABF90627"/>
        <property type="gene ID" value="MXAN_1675"/>
    </dbReference>
    <dbReference type="GeneID" id="41359114"/>
    <dbReference type="KEGG" id="mxa:MXAN_1675"/>
    <dbReference type="eggNOG" id="COG2937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330329_0_0_7"/>
    <dbReference type="OMA" id="HEACAWR"/>
    <dbReference type="OrthoDB" id="44146at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:fatty-acyl-CoA reductase (alcohol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="493"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="868" mass="96104" checksum="36C32C7276628CE0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBT2</accession>
    <name>Q1DBT2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-tyvelose-2-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbE</name>
        <name evidence="2" type="ORF">MXAN_1639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551750.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1639"/>
    <dbReference type="EnsemblBacteria" id="ABF87909">
        <property type="protein sequence ID" value="ABF87909"/>
        <property type="gene ID" value="MXAN_1639"/>
    </dbReference>
    <dbReference type="GeneID" id="41359081"/>
    <dbReference type="KEGG" id="mxa:MXAN_1639"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_7"/>
    <dbReference type="OMA" id="MGTEDQG"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="366" mass="39502" checksum="B6219091CAF53CD1" modified="2006-07-11" version="1">MSAAEPWKVEGGRTVIFGGAGFIGSNLADHYLSAGRTVRVVDNLTRPGVVHNLRWLQARHGARLEVVTADVRDAHAVKQSVVGASEVFHFAAQGAVTTSLETPVTDFEVNAGGTLNVLEALRAMERPASLVFTSTNKVYGCTPGVEFVQKPSRYAPRDAGLRGHGVGEDCPVDFESPDGCSKGAADQYVLDYARAYGLRTVVFRMSCIYGPRQFGTEDQGWVAHFLLCMLEGRPLTLYGDGKQVRDILDVGDLVRALGLAQQHIGRLKGQAFNIGGGPSRTVSLLDLLGLISQRTGLRPALQFEDGRTGDPRYYVSDPRKFQAATGWAPQVGIAEGVDRLHDWLRTLMLERPVASGQGGAREVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCG0</accession>
    <name>Q1DCG0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551523.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1406"/>
    <dbReference type="EnsemblBacteria" id="ABF92143">
        <property type="protein sequence ID" value="ABF92143"/>
        <property type="gene ID" value="MXAN_1406"/>
    </dbReference>
    <dbReference type="GeneID" id="41358853"/>
    <dbReference type="KEGG" id="mxa:MXAN_1406"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1575827_0_0_7"/>
    <dbReference type="OMA" id="DPDGGWI"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="157" mass="17212" checksum="35F63624F3D0365A" modified="2006-07-11" version="1">MPTLDIPITLLDPDGGWINTPVHVSELDELPVLLHFFSVKQRGADEDIDAVKRIIAEYGARGLKVISVDVTHSDKELRDTNAVEAFARKHGLYHPIAVDDGSMARAYDVADTPAWLVFDADSGRLRHHFSGKNASPHVRQVLERFIQASAAAPSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCH4</accession>
    <name>Q1DCH4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551509.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1392"/>
    <dbReference type="EnsemblBacteria" id="ABF88060">
        <property type="protein sequence ID" value="ABF88060"/>
        <property type="gene ID" value="MXAN_1392"/>
    </dbReference>
    <dbReference type="GeneID" id="41358839"/>
    <dbReference type="KEGG" id="mxa:MXAN_1392"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040417_0_0_7"/>
    <dbReference type="OMA" id="VAFAWCR"/>
    <dbReference type="OrthoDB" id="802902at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="374" mass="42855" checksum="8DA6E4428731CAEB" modified="2006-07-11" version="1">MSGDWREQVESLFAQADGLAEGESKVRLLEEAVRLADTHKDVGMGYRMRDALIDAATFGGFPDKALVAFAWCRGQQKKDPKRFDPEEMFWKQKWVVGRIKEFPHITRKQILDALDDVEQCFRATDSGVRAVLKMRYQAAREMGDAAEEVERLWNAWLETRRDHLTDCRVCELDDELDHHADKGEWQQVLRKAKPILDGRKSCAEIPHLTLGTVLYPLFKLGELEHAREIHRRGYAMVTKNREFLSTVGEHMEFLALTDNLARGLTLLEKHLGWALDHPSYRDRFTFYAAAAFLLERVLAAGDRDVVSLRLPKTFPNHQADGGYDVRALHAWTLGQARDIANRFDTRNGTDRFAKLLARNQVLAGEVRPFPIDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI5</accession>
    <name>Q1DCI5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase, M3 (Thimet oligopeptidase) family</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1381"/>
    <dbReference type="EnsemblBacteria" id="ABF92202">
        <property type="protein sequence ID" value="ABF92202"/>
        <property type="gene ID" value="MXAN_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1381"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_2_1_7"/>
    <dbReference type="OMA" id="MWGQEAN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="212"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="653" mass="73490" checksum="752949BE29A5205C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCR1</accession>
    <name>Q1DCR1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551422.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1305"/>
    <dbReference type="EnsemblBacteria" id="ABF89152">
        <property type="protein sequence ID" value="ABF89152"/>
        <property type="gene ID" value="MXAN_1305"/>
    </dbReference>
    <dbReference type="GeneID" id="41358752"/>
    <dbReference type="KEGG" id="mxa:MXAN_1305"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643769_0_0_7"/>
    <dbReference type="OrthoDB" id="1684783at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011959">
        <property type="entry name" value="CHP02270"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02270">
        <property type="entry name" value="TIGR02270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="440" mass="46928" checksum="A17CCCDA4829C380" modified="2006-07-11" version="1">MNPLPRHLSLPISWEMLASHLDEAGFLWRQWKRALVAPDHVVDDVAGVEARLLAHVDALVLAGRKAATRLLVPALAEADEPGRVECAALGLLLQEDALDGAVRSVLEVLQAGEEGLCAGIQAALLCAGGRGLESWLRPMVDASPPPGGLATLLEILGAWRVDPGPALEASLTHEAAQVRAAAFRCLRSWPVRLSESTLELGLRSSSAEVSGAALEAGLLAGSRLAWWECRRQVLEGGPHRQRALRALAVAGGPDAQKLLLEGLGDAARGTETLRVVGLVGTVETARACLEAMREPPWARLAAESFSLVTGMEVPAVAPGVESGDEAAAVEFAPEADLPLPDVPRVEAWWAEHAPRFKPTVRYVRGRPLGQESLLDALREGSMYRRRSLWWAVALRTRGALGLGVGAWTRTQRAEEDAVRRLPPARFAQSLEGGLGAWGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCY6</accession>
    <name>Q1DCY6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M15_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551347.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1228"/>
    <dbReference type="EnsemblBacteria" id="ABF87029">
        <property type="protein sequence ID" value="ABF87029"/>
        <property type="gene ID" value="MXAN_1228"/>
    </dbReference>
    <dbReference type="GeneID" id="41358677"/>
    <dbReference type="KEGG" id="mxa:MXAN_1228"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509704_0_0_7"/>
    <dbReference type="OMA" id="ISRCEAR"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="1">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="177" mass="19590" checksum="B0514ED48BA76390" modified="2006-07-11" version="1">MTRANFHRVDLDRVFLPFVAVSLEVITRCAARGVRYVATHGFRDLPEQAELRRLYVAGKGGKASPAGLSAHNYGLAFDFVCDASPRPGVQPDWRESAYRVLGDESTKAGLVWGGRFGDSPHVQWPGYVSALQLTPLRTLVQQSSLADVWARLDAERLSPKWRAANPKLAAELERLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCZ1</accession>
    <name>Q1DCZ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail assembly chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551342.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1223"/>
    <dbReference type="EnsemblBacteria" id="ABF91954">
        <property type="protein sequence ID" value="ABF91954"/>
        <property type="gene ID" value="MXAN_1223"/>
    </dbReference>
    <dbReference type="GeneID" id="41358672"/>
    <dbReference type="KEGG" id="mxa:MXAN_1223"/>
    <dbReference type="HOGENOM" id="CLU_159200_0_0_7"/>
    <dbReference type="OMA" id="MMMIARI"/>
    <dbReference type="OrthoDB" id="2139231at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038556">
        <property type="entry name" value="TAC_Gp13-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="117" mass="13137" checksum="F8D016A3E9BDEF86" modified="2006-07-11" version="1">MSNKHKLLAKNRRVLKSVEVDGVKVNIIKPTMGDRLRLIEQAREAGEMTEKNEPTGDRAGARMLGRIAVCVLHDAETGRPMFSVNDIDELLDESWLEDLATDLTDAFNVSEEKMRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCZ5</accession>
    <name>Q1DCZ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551338.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1219"/>
    <dbReference type="EnsemblBacteria" id="ABF90053">
        <property type="protein sequence ID" value="ABF90053"/>
        <property type="gene ID" value="MXAN_1219"/>
    </dbReference>
    <dbReference type="GeneID" id="41358668"/>
    <dbReference type="KEGG" id="mxa:MXAN_1219"/>
    <dbReference type="HOGENOM" id="CLU_120978_0_0_7"/>
    <dbReference type="OMA" id="VELHVAQ"/>
    <dbReference type="OrthoDB" id="2216416at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024411">
        <property type="entry name" value="Minor_capsid_phage"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12691">
        <property type="entry name" value="Minor_capsid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="14700" checksum="7C3BEB62468FC935" modified="2006-07-11" version="1">MARDTAADLATILAGGGLNLSAGANLFLGPTLEDDDATVPDVACFVLQTGGEPPQSYIGGGRKTYRTVTCQVRVRSARERFREGQALALAALDVLHLASAAPYVLIEVDEGSPNYIGTDGSDRHWWTFTVDASFIDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDK0</accession>
    <name>Q1DDK0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylornithine deacetylase</fullName>
            <ecNumber evidence="5">3.5.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argE</name>
        <name evidence="5" type="ORF">MXAN_1012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family. ArgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551133.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DDK0"/>
    <dbReference type="STRING" id="246197.MXAN_1012"/>
    <dbReference type="EnsemblBacteria" id="ABF90586">
        <property type="protein sequence ID" value="ABF90586"/>
        <property type="gene ID" value="MXAN_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="41358467"/>
    <dbReference type="KEGG" id="mxa:MXAN_1012"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_4_7"/>
    <dbReference type="OMA" id="WAVTKSY"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01108">
        <property type="entry name" value="ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010169">
        <property type="entry name" value="AcOrn-deacetyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01892">
        <property type="entry name" value="AcOrn-deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="4">
        <location>
            <begin position="173"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="380" mass="40715" checksum="7233FEB6763CF71A" modified="2006-07-11" version="1">MSDTLPALRATLTELVAMDTTSFRPNVPLIDYAQARLEAAGFSAERQKFLDDAGVEKVNLVAVKGGSGSGRAALALVGHSDCVPYDAAWTDALRLTEKDGRLYARGACDTKGFIACALHAALNAEQLKAPLMVVLTADEEVGLTGAKKLVEAGLGRARHAIVGEPTRLIPVRANKGYCLAEVEVRGKEGHSAYPDSGASAIFRAGRFLQRLEHLALTVLREDLDEGFQPPFTTVNVGVIQGGKAKNVIPGACRFVVEWRPIPGQPPERVSQLLETIRQELVRDEPAFEAQIRVVRTDRGVNTRADAEVVRFLAEASGNAPETVSFGTEAPQMTELGAEAVVFGPGDIRVAHQTGEYVPVEDLVRCEAVLARAVAHFCGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDK6</accession>
    <name>Q1DDK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551127.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1006"/>
    <dbReference type="EnsemblBacteria" id="ABF91339">
        <property type="protein sequence ID" value="ABF91339"/>
        <property type="gene ID" value="MXAN_1006"/>
    </dbReference>
    <dbReference type="GeneID" id="41358461"/>
    <dbReference type="KEGG" id="mxa:MXAN_1006"/>
    <dbReference type="HOGENOM" id="CLU_154541_0_0_7"/>
    <dbReference type="OMA" id="VYREMAD"/>
    <dbReference type="OrthoDB" id="1657305at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="15328" checksum="4F710716CDC6752A" modified="2006-07-11" version="1">MSLNREWRHGEQQAWFEAPDILWARFRGAITLETSVWSCGVYREMADAQRFYLAADITDSHLSPESRRYLVDHAQAGWFLGVVYIGAAMEQKATTKSLMVGAMLSGGMRLDTAYVDSAEEARAWIARHREAAARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE72</accession>
    <name>Q1DE72_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLDc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550911.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0788"/>
    <dbReference type="EnsemblBacteria" id="ABF92000">
        <property type="protein sequence ID" value="ABF92000"/>
        <property type="gene ID" value="MXAN_0788"/>
    </dbReference>
    <dbReference type="GeneID" id="41358255"/>
    <dbReference type="KEGG" id="mxa:MXAN_0788"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084490_0_0_7"/>
    <dbReference type="OMA" id="ENNREMG"/>
    <dbReference type="OrthoDB" id="1927616at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLDc_2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="28429" checksum="1EAF0EA3678114D4" modified="2006-07-11" version="1">MFENFFRSRDADALEVLGKVDTVRRLHGLIDEAQKHVTLISPYVSIEKLRDIERKIRQALEREVAVTLVIREGDESTRGPSQQGVELLVSLMQAGMRLFVVRDLHAKLYYSERHALITSLNLIESSFNNSIEVGICISAGRAEYVRISDFIESEITPHRKEVPFKPATEPRRRSATPVPRHATQGFCIRCRDAIGFNPERPYCDSDFNVWRRYSDPTYEDNHCHHCGMDFAASKNKPLCRKCYGMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA4</accession>
    <name>Q1DEA4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0753"/>
    <dbReference type="EnsemblBacteria" id="ABF92667">
        <property type="protein sequence ID" value="ABF92667"/>
        <property type="gene ID" value="MXAN_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0753"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066103_1_0_7"/>
    <dbReference type="OMA" id="LFHVTID"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="208" mass="22201" checksum="DF97664471E65D90" modified="2006-07-11" version="1">MLDVQGTPLAGTHERPGQYVHLRLPGVGQGLFAIASPPGRPGTQWEFLLKVGSPLPDALIHLPRGAHVDVSRPEGRGFPLERARGQDVLLFATGSGISAIRSVITSIQLERGAYGQVTLYFGARTPGAFAYTDELHEWEAGGVRVVRTVSQPGASGWQGLTGYVQAHLAEEPVQAAVAFLCGQKEMVRGVMTTLQARGMPAGDIHLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEE8</accession>
    <name>Q1DEE8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0707"/>
    <dbReference type="EnsemblBacteria" id="ABF90988">
        <property type="protein sequence ID" value="ABF90988"/>
        <property type="gene ID" value="MXAN_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0707"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073078_1_0_7"/>
    <dbReference type="OMA" id="QWARMLR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="310" mass="33905" checksum="E501B0DB122F61A9" modified="2006-07-11" version="1">MHRPPNLRNRAGRGALGQGLASSRGMRRRRHARMAHRARPMPPPRLARARVPPSREDRWLGRVFFGPRRLMYVGPLAPTDPHAHPTFQVLLSLDAPVRLRDARQQEVACQAAVVPPDAEHAIVEGALAAVLLHVPAEDLVGRRLATLGIGADAAAWGAAGERLRACGIGRLPVRWAEAEAQTQVLLRELQADAGVAKPTHPAVKKLLRLLPEALEEDVRLATLAPRVGLSVGRLSHLFSAQVGFPLRPYILWLRLHRAAEHLQQGASLTEAAHAAGFTDSAHLNHAFRRTFGLKPSEIAGVVEWVRPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEU8</accession>
    <name>Q1DEU8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550688.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0556"/>
    <dbReference type="EnsemblBacteria" id="ABF86680">
        <property type="protein sequence ID" value="ABF86680"/>
        <property type="gene ID" value="MXAN_0556"/>
    </dbReference>
    <dbReference type="GeneID" id="41358040"/>
    <dbReference type="KEGG" id="mxa:MXAN_0556"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_7"/>
    <dbReference type="OMA" id="DFPTLAW"/>
    <dbReference type="OrthoDB" id="1320028at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="475" mass="52577" checksum="F2C17EA61E793353" modified="2006-07-11" version="1">MDLHVDLQDRRDVAGQIYRGLRARILDGRLRDGEQVPPSRELAQRLGVSRNTVGVAYEWLTAEGLLVGRGRAGSFVQNAPRERGARAAATRGVKLRPRAVWSELHVPPPAEPPAPYDFRVGNPDAALFPFEAWHRLLARHLRAAAMTAAYADPAGHPELREAVARHVGVSRGVRAEASDVLITHGAQQALDLAGRVLLEPGDRVAVEEPGYPPARLLFQSLGAHVVPVPVDKEGLDVQALPDDTRLVYVTPSHQFPLGIVMSPARRRALLDWARRRDAVVIEDDYDSEFRFGGRPLETLHSLDRSGRVLYVGSFSKVLLPALRLGFLVAPPSLQRELRLAKQVTDWHSQLPAQAALARFIDTGALARHLRKTRREYEQRHTRLSEKLRHHFGDALEQLPSVAGLHLCVTFTRGGARLERELTRRARDAGIGIEALSGYFAGAPTRHGWVLGYGGVTVDRIDEGLWRLRTRLAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF13</accession>
    <name>Q1DF13_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91948">
        <property type="protein sequence ID" value="ABF91948"/>
        <property type="gene ID" value="MXAN_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0490"/>
    <dbReference type="HOGENOM" id="CLU_3346281_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="37" mass="4252" checksum="1401E9F796A55952" modified="2006-07-11" version="1">MAQLPLLVLRWRPGPQATAHVTVYVFRVPCSVTRKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF77</accession>
    <name>Q1DF77_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0426"/>
    <dbReference type="EnsemblBacteria" id="ABF89296">
        <property type="protein sequence ID" value="ABF89296"/>
        <property type="gene ID" value="MXAN_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0426"/>
    <dbReference type="HOGENOM" id="CLU_2024237_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13674" checksum="AC6076ADB70A6690" modified="2006-07-11" version="1">MNTPNMRAVEAAASAKAALLEEELEQGQRPPDEVERILFHLSRHTRAAAIAQLLAYADGATFRDRLVRSGQPHRRRLQWATGELRPFNRFTATGHYGPLCDSLAPGWASWPTTLPACRRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG52</accession>
    <name>Q1DG52_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, 2OG-Fe(II) oxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550235.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0088"/>
    <dbReference type="EnsemblBacteria" id="ABF88620">
        <property type="protein sequence ID" value="ABF88620"/>
        <property type="gene ID" value="MXAN_0088"/>
    </dbReference>
    <dbReference type="GeneID" id="41357595"/>
    <dbReference type="KEGG" id="mxa:MXAN_0088"/>
    <dbReference type="eggNOG" id="COG3491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_7"/>
    <dbReference type="OMA" id="WHFGQYV"/>
    <dbReference type="OrthoDB" id="400496at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="356" mass="39324" checksum="4D29B56A26296B95" modified="2006-07-11" version="1">MTGPDSARGGLPVIDMASLFDASRVTERARVAREIEQACRDSGFFYVTGHGVSGEVLARLERESHRFFALPRVAKEAIAMSMGGVAWRGWFPLGGELTSGRPDRKEGLYLGTELGSEHPRVKAGWPLHGANLWPAEVPELRAAVLDYVAACTRAAHALMEGMALSLGLDADYFRRHYTADPTVLFRIFHYPAEPQHEEVSWGVGEHTDYGLLTLLAQDDNGGLQVKTPRGWVEVPPLPGTLVCNIGDMLDRMTGGWYRSTPHRVKNVSGKDRLSFPLFFDPDFAAEVHPLPRGAGADVDDDRARRWDGASVHAFQGTYGDYLLGKVSKVFPELVRRVWERAPTALPEETPRGPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG56</accession>
    <name>Q1DG56_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550231.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0084"/>
    <dbReference type="EnsemblBacteria" id="ABF90165">
        <property type="protein sequence ID" value="ABF90165"/>
        <property type="gene ID" value="MXAN_0084"/>
    </dbReference>
    <dbReference type="GeneID" id="41357591"/>
    <dbReference type="KEGG" id="mxa:MXAN_0084"/>
    <dbReference type="HOGENOM" id="CLU_1068857_0_0_7"/>
    <dbReference type="OMA" id="ISRWNIH"/>
    <dbReference type="OrthoDB" id="2106527at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="34827" checksum="EAF14D832CE37737" modified="2006-07-11" version="1">MASSDTHLAWDPKTLNHTERPSGFGCLWRHTITDNGGWSSHPCNHMSNCYEVSLNERSALYNKDHQAIARRMKLVQEDFALSSKAKKRIWKRFPVSDNSKRKLTLSDFFDKGRQSLYWLRRGPEGWHIGVKHLDPVPNQTLKKGNRPQFQPRQNQLQGGYGAFYPYEHNYHHLIPVGAVEEWVIGKGESGSPARSDQVVKLILISRWNIHNEKNMVLLPQQEFEALIVGLPAHCPWGVPAHAAYQSSLQGRLRKLRSKIDRAIRQKKHPKDLKADIIEELDSLSNALLSQVENMRAGVQLGPVNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q07766</accession>
    <accession>Q1CW49</accession>
    <name>DEVS_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>CRISPR-associated protein Cas5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Fruiting body developmental protein S</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">devS</name>
        <name type="synonym">cas5</name>
        <name type="ordered locus">MXAN_7261</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="7450" last="7462">
            <title>devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus.</title>
            <authorList>
                <person name="Thoeny-Meyer L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="7693658"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="J. Bacteriol." volume="189" first="3738" last="3750">
            <title>Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.</title>
            <authorList>
                <person name="Viswanathan P."/>
                <person name="Murphy K."/>
                <person name="Julien B."/>
                <person name="Garza A.G."/>
                <person name="Kroos L."/>
            </authorList>
            <dbReference type="PubMed" id="17369305"/>
            <dbReference type="DOI" id="10.1128/JB.00187-07"/>
        </citation>
        <scope>FUNCTION IN NEGATIVE AUTOREGULATION</scope>
        <scope>INDUCTION</scope>
        <scope>OPERON STRUCTURE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="function">
        <text evidence="2">Has a role in fruiting body development, sporulation and aggregation.</text>
    </comment>
    <comment type="developmental stage">
        <text>Operon expression begins by 6 hours after starvation has initiated development and is under strong negative autoregulation.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Part of an operon going from at least MXAN_7266 to MXAN_7259 that includes a CRISPR operon with transcription continuing into the pre-crRNA locus.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Essential for sporulation, decreases sporulation 100 to 1000-fold. Negative autoregulation by this gene product relies on DNA both upstream and downstream of the operon's promoter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CRISPR-associated protein Cas5 family.</text>
    </comment>
    <dbReference type="EMBL" id="L19029">
        <property type="protein sequence ID" value="AAA16135.1"/>
        <property type="molecule type" value="Unassigned_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C49941">
        <property type="entry name" value="C49941"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557180.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q07766"/>
    <dbReference type="STRING" id="246197.MXAN_7261"/>
    <dbReference type="EnsemblBacteria" id="ABF89647">
        <property type="protein sequence ID" value="ABF89647"/>
        <property type="gene ID" value="MXAN_7261"/>
    </dbReference>
    <dbReference type="GeneID" id="41364427"/>
    <dbReference type="KEGG" id="mxa:MXAN_7261"/>
    <dbReference type="eggNOG" id="ENOG502Z8P6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1325024_0_0_7"/>
    <dbReference type="OMA" id="LPYWVDH"/>
    <dbReference type="OrthoDB" id="1400944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013415">
        <property type="entry name" value="Cas5_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02586">
        <property type="entry name" value="cas5_cmx5_devS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0293">Fruiting body</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="chain" id="PRO_0000079872" description="CRISPR-associated protein Cas5">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17369305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="7693658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="214" mass="23303" checksum="748EA24915A86675" modified="1994-10-01" version="1">MIALELSVPVACWRKGRARELVETEVLPPPATCYGALLSLVGEQDRERHRGCRVTAGVLNAPVISTVLRTFWRSKNLKVAKGNDENAAPDQQQLVIDARLVVWCDSREEPDSGESLEDRVVRAMREPGSVTRAGGWSLGESTHLINDARLLPEGRPPAGCRAFLTASTGALTLPVWVDHVGTRGTRYEVGRLEEVLAAPEVQRLPRIPLAEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU4</accession>
    <name>Q1CVU4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7372"/>
    <dbReference type="EnsemblBacteria" id="ABF88175">
        <property type="protein sequence ID" value="ABF88175"/>
        <property type="gene ID" value="MXAN_7372"/>
    </dbReference>
    <dbReference type="GeneID" id="41364532"/>
    <dbReference type="KEGG" id="mxa:MXAN_7372"/>
    <dbReference type="eggNOG" id="COG1571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831288_0_0_7"/>
    <dbReference type="OMA" id="RSDWAPH"/>
    <dbReference type="OrthoDB" id="1472466at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="323" mass="35194" checksum="49D52FC25D130219" modified="2006-07-11" version="1">MSAESVRVAPCQRCDSALEAEDLRCPICGLTAPPPPHAAVERARARVVRCDSCGAAVEYSVEAKAPRCGYCGSVTHVETTADPVEQAQHWLPFTVDTEAARGALMGFLGRGGFFRPSGLAQEASLESLRPVWWPAWMFDAGVDVSWTADSNAGSRRSDWAPHAGRTRFDFEGIPVPASRGLKVRECEALAPHYQRGSRLDTPHGPEGAHVERFEATRSGARRSVLEAVERLAIERLQQGVIPGSRFRNIHVAVALFSLRTQRLALPVYVLAYRYRDKPYRVLVHGQDVQVVLGEAPISPLRVAAVILATLLVLVAVLYGVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWG5</accession>
    <name>Q1CWG5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7145"/>
    <dbReference type="EnsemblBacteria" id="ABF89917">
        <property type="protein sequence ID" value="ABF89917"/>
        <property type="gene ID" value="MXAN_7145"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7145"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="ALINCPK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="25766" checksum="27045CA3E4E8DB2F" modified="2006-07-11" version="1">MAQEDAGAEPGKALIHLDGLTKVFETEDVETHALSNIHLNVRKGEWVAIVGPSGSGKSTLLAVLGLLDTATRGAYLLDGRSVLDLSATDRALVRNRHIGFIFQSFNLIGDLTVFENVELPLTYRGMPAAERKQRVERALEKVGMAHRARHMPGQLSGGQQQRVAVARAVAGDPLILLADEPTGNLDSKNGEAVMQLLTELHKGGATICMVTHDPAHARVATRTVSLFDGRIVQDEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWQ4</accession>
    <name>Q1CWQ4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556975.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7056"/>
    <dbReference type="EnsemblBacteria" id="ABF88264">
        <property type="protein sequence ID" value="ABF88264"/>
        <property type="gene ID" value="MXAN_7056"/>
    </dbReference>
    <dbReference type="GeneID" id="41364231"/>
    <dbReference type="KEGG" id="mxa:MXAN_7056"/>
    <dbReference type="HOGENOM" id="CLU_2586034_0_0_7"/>
    <dbReference type="OrthoDB" id="1915566at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018684">
        <property type="entry name" value="DUF2171"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09939">
        <property type="entry name" value="DUF2171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="80" mass="8913" checksum="0BAB211EE4E10C71" modified="2006-07-11" version="1">MFSRSEIHKGMKVRGNDGHVLGRIIKMTGDELIVEKGLIRRHDFAVSLADVREVVGGEVLLNHGRDSLFSAPREVPPTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXF6</accession>
    <name>Q1CXF6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppsA</name>
        <name evidence="14" type="ORF">MXAN_6800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6800"/>
    <dbReference type="EnsemblBacteria" id="ABF90724">
        <property type="protein sequence ID" value="ABF90724"/>
        <property type="gene ID" value="MXAN_6800"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6800"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_7"/>
    <dbReference type="OMA" id="LETWFFL"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="359"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="455"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF90724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="762" mass="81897" checksum="507041D7C3FC150B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI3</accession>
    <name>Q1CXI3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556698.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6773"/>
    <dbReference type="EnsemblBacteria" id="ABF90776">
        <property type="protein sequence ID" value="ABF90776"/>
        <property type="gene ID" value="MXAN_6773"/>
    </dbReference>
    <dbReference type="GeneID" id="41363964"/>
    <dbReference type="KEGG" id="mxa:MXAN_6773"/>
    <dbReference type="eggNOG" id="COG2154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_4_3_7"/>
    <dbReference type="OMA" id="NFAQMVG"/>
    <dbReference type="OrthoDB" id="1862336at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="103" mass="11380" checksum="7AF11F3E79D0B714" modified="2006-07-11" version="1">MASKPTLLAPEALQSFLSQHTEWKHEGGMIRRTFEAPTFLAGIAFVEQVAQAAEKADHHPDIDIRWRKVTLALVTHDAGGLTARDTALATEADRLFTEATRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXL9</accession>
    <name>Q1CXL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556662.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6737"/>
    <dbReference type="EnsemblBacteria" id="ABF89838">
        <property type="protein sequence ID" value="ABF89838"/>
        <property type="gene ID" value="MXAN_6737"/>
    </dbReference>
    <dbReference type="GeneID" id="41363929"/>
    <dbReference type="KEGG" id="mxa:MXAN_6737"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367161_0_0_7"/>
    <dbReference type="OrthoDB" id="357683at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187726" evidence="1">
        <location>
            <begin position="23"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="2">
        <location>
            <begin position="443"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="759" mass="82185" checksum="B655A4287D1F878D" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXW6</accession>
    <name>Q1CXW6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556565.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6640"/>
    <dbReference type="EnsemblBacteria" id="ABF92405">
        <property type="protein sequence ID" value="ABF92405"/>
        <property type="gene ID" value="MXAN_6640"/>
    </dbReference>
    <dbReference type="GeneID" id="41363837"/>
    <dbReference type="KEGG" id="mxa:MXAN_6640"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544929_0_0_7"/>
    <dbReference type="OMA" id="MLQENDF"/>
    <dbReference type="OrthoDB" id="939031at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="544" mass="57220" checksum="CF8DCB0ED6E87E87" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX8</accession>
    <name>Q1CXX8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556553.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6627"/>
    <dbReference type="EnsemblBacteria" id="ABF90093">
        <property type="protein sequence ID" value="ABF90093"/>
        <property type="gene ID" value="MXAN_6627"/>
    </dbReference>
    <dbReference type="GeneID" id="41363824"/>
    <dbReference type="KEGG" id="mxa:MXAN_6627"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574793_0_0_7"/>
    <dbReference type="OMA" id="GYFEKPF"/>
    <dbReference type="OrthoDB" id="434730at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="470" mass="51665" checksum="B86D38371EFC07C7" modified="2006-07-11" version="1">MEGRMHLPRWLEHPGADCLTLPFASGTVRPAMAPRILVVDDNQELLSLLTQLFEEAGYEVIGASRGKQAVELAKAQPPAAAVLDILLPDMMGYHLADALRKDNPQLPLLFITGVFKGGKHAVEARTKYQAAGYFEKPFEAQKLLEAMTKVLPPEKPAAAAASLQDAFEVELDIDVEEEGPQDAMELTGRIKVTGGGNITAEIRGANLTASPMQKVPATQVRPPTPGRPPDPPPAGAPGSRRGEIRDNLPSLLTAFYLSRETGELGVQKGKVKKVVYFEKGTPVFALSNLLADRFGQFLVRVGKIKPEQLQDASAVAAQSNRRTGDVLVERGLLKDTERLYYVGQQVKAVIYSLFAWDEGTYVLSFREKASAESIKLDVHPANLIVRGIKKLYKPERLRRLLQPEDRLIPAVAPAYQLNEVELERWEAELLPKIDGNRTVAELLAFANRPEHVVYGFLVAMMSLGILDKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY23</accession>
    <name>Q1CY23_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative TonB-dependent receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_6579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556508.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6579"/>
    <dbReference type="TCDB" id="1.B.14.3.2">
        <property type="family name" value="the outer membrane receptor (omr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92530">
        <property type="protein sequence ID" value="ABF92530"/>
        <property type="gene ID" value="MXAN_6579"/>
    </dbReference>
    <dbReference type="GeneID" id="41363783"/>
    <dbReference type="KEGG" id="mxa:MXAN_6579"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421910_0_0_7"/>
    <dbReference type="OMA" id="YRPRHKW"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188165" evidence="6">
        <location>
            <begin position="24"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Plug" evidence="8">
        <location>
            <begin position="52"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="7">
        <location>
            <begin position="354"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="669" mass="71190" checksum="98FFE87D0A48C507" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYH7</accession>
    <name>Q1CYH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556354.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6422"/>
    <dbReference type="EnsemblBacteria" id="ABF91643">
        <property type="protein sequence ID" value="ABF91643"/>
        <property type="gene ID" value="MXAN_6422"/>
    </dbReference>
    <dbReference type="GeneID" id="41363632"/>
    <dbReference type="KEGG" id="mxa:MXAN_6422"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087262_0_0_7"/>
    <dbReference type="OMA" id="GRRNDGM"/>
    <dbReference type="OrthoDB" id="1785930at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188045" evidence="2">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="109"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="284" mass="30245" checksum="BAC1C5BE9066FE1A" modified="2006-07-11" version="1">MRPLMSLRLPLLAVFPLSVLVGCATVKPRPSEPVATTEAVTVAAPGGLAEPVPVPVTAVELGTTEVAPTVVATQWVSAGVLEATLRAAEQVTGPASTTGRFWDVVLAPTQMSRSIVQRSLQLVGMRSLRRVSRGVPDDCSGFVRLAYRSAGIDLVAHGFRAGENAVSAIFRRAVDVGSVHHQPPRPGDLVFFRETYDRNRDGRRNDGMTHIGVVEAVDAHGTVTFIHRGGKGVARSRLNLSFPSRHQLEQGGPVVNDYIRPAAKGSRAYLAGELFAAFASPEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYT5</accession>
    <name>Q1CYT5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556246.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6313"/>
    <dbReference type="EnsemblBacteria" id="ABF89860">
        <property type="protein sequence ID" value="ABF89860"/>
        <property type="gene ID" value="MXAN_6313"/>
    </dbReference>
    <dbReference type="GeneID" id="41363529"/>
    <dbReference type="KEGG" id="mxa:MXAN_6313"/>
    <dbReference type="eggNOG" id="COG3509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_4_1_7"/>
    <dbReference type="OMA" id="IRRYLIH"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187747" evidence="3">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="36216" checksum="96C0AB75A1DBB72D" modified="2006-07-11" version="1">MRFRRTRLALGVLLAGATACSSSDTSRRPTGDAGIVPPTVEEPTVPERTACTGLTVGPGTYDWTVEHDGRTRNYRVHVPPGYDATRPTAAVVAFHGLGSNEVEMEGLTRLSTLADTEGFLAVYPRGLSTSEINHQGTDGPYRGWNAGACCGPAWTAKVDDVGFVDTLLADLDTRVCVDTRRTFATGLSNGGFFSYQLACRRASRFAAIAPVAGMEGATPCNPSRPVPVLHMHGTADPVIRYQGGNNLGIFGGAYPSAEESVRRWAERNGCTGPTVETYQQGDSTCTAATGCSPESATASLCTVQGGQHTWPGFTDFNHGGTPHLDATREAWKFFQARPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV3</accession>
    <name>Q1CYV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88803">
        <property type="protein sequence ID" value="ABF88803"/>
        <property type="gene ID" value="MXAN_6294"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6294"/>
    <dbReference type="HOGENOM" id="CLU_1359193_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006728">
        <property type="entry name" value="EsaG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04634">
        <property type="entry name" value="DUF600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="201" mass="22178" checksum="039CF35B2BA2F1F1" modified="2006-07-11" version="1">MATSIRTASAMSHRPGVSKSVMGVSEVLAPGVERAISSTARCTDDPLQQTGLPSILYFAPASFGLTGQSARPRRAVCSPTPDSRRDARHRTASPDHRPRRVQQAEDGWVQATYSYLAIPLFSEETGRYRLADGQQRSFAATDEVTDAFDELRTRMATLSKNGHDWHTATLTITADGKFAFDFNYDDLPQLEVVPICRQMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ68</accession>
    <name>Q1CZ68_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556118.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6174"/>
    <dbReference type="EnsemblBacteria" id="ABF91292">
        <property type="protein sequence ID" value="ABF91292"/>
        <property type="gene ID" value="MXAN_6174"/>
    </dbReference>
    <dbReference type="GeneID" id="41363403"/>
    <dbReference type="KEGG" id="mxa:MXAN_6174"/>
    <dbReference type="eggNOG" id="ENOG5031D8N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488121_0_0_7"/>
    <dbReference type="OMA" id="WFWVSAS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="18713" checksum="6ECFD3E352CE0510" modified="2006-07-11" version="1">MGSTDIQLLQRRVRRTYELARLRRALVGVLPIVVVTAIAALLASRPAPPLTFGLATALMGAMMLWHGRDPQKAFLPGVIAGLVPLALALGTGTLHTCGTANCSFLCIPACVLGGVVAGMAVSGVSLQRRAGPWFWVSASGLALLTGAMGCACMGASGIVGLGMGFGAGIVPGLLRRAFSKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ71</accession>
    <name>Q1CZ71_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88453">
        <property type="protein sequence ID" value="ABF88453"/>
        <property type="gene ID" value="MXAN_6171"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6171"/>
    <dbReference type="HOGENOM" id="CLU_3313174_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="39" mass="4464" checksum="B4BD33238DB92E6F" modified="2006-07-11" version="1">MPEARDVLAQKHLSEVSKDEFATYLQVQLLTLQLNEAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY8</accession>
    <name>Q1CZY8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555849.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5898"/>
    <dbReference type="EnsemblBacteria" id="ABF93088">
        <property type="protein sequence ID" value="ABF93088"/>
        <property type="gene ID" value="MXAN_5898"/>
    </dbReference>
    <dbReference type="GeneID" id="41363137"/>
    <dbReference type="KEGG" id="mxa:MXAN_5898"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084200_0_0_7"/>
    <dbReference type="OMA" id="WQIVNTS"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="230" mass="25439" checksum="3D151865B2691CDF" modified="2006-07-11" version="1">MGVVYLVRHGQASFGAANYDQLSETGLVQARVLGESLRERLPRVDAVVTGTMARHRQTAEACLAALGCGTVAVQTAGFNEFDHEEIVARHTPRYADPEVLRAELSQTESPRRAYQALFADAVARWVAGQHDAEYTEPWSAFGERCRRAMDALIQEMGASKNALVFTSGGTITAICQELLHILDEHAFRLNLTLANCGLTKVIYSERGRYLSTLNEHSHFEGAQRALLTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D005</accession>
    <name>Q1D005_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5881"/>
    <dbReference type="EnsemblBacteria" id="ABF86082">
        <property type="protein sequence ID" value="ABF86082"/>
        <property type="gene ID" value="MXAN_5881"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5881"/>
    <dbReference type="eggNOG" id="ENOG5031CMV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2807932_0_0_7"/>
    <dbReference type="OMA" id="GENITKW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="70" mass="7969" checksum="4BB9549ADC25AC5D" modified="2006-07-11" version="1">MTRVGMGVISFTGVKVFSTTLARDRENMGENITKWLKENSNLEVVDRVVTQSSDKEFHCLTITLFYKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D031</accession>
    <name>Q1D031_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555806.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5855"/>
    <dbReference type="EnsemblBacteria" id="ABF91892">
        <property type="protein sequence ID" value="ABF91892"/>
        <property type="gene ID" value="MXAN_5855"/>
    </dbReference>
    <dbReference type="GeneID" id="41363094"/>
    <dbReference type="KEGG" id="mxa:MXAN_5855"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753798_0_0_7"/>
    <dbReference type="OMA" id="REEDLFF"/>
    <dbReference type="OrthoDB" id="824536at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42557" checksum="F0D6B86B98DC6CA7" modified="2006-07-11" version="1">MNLRARRVGRHVALCWGMRTAPARMLSFMAALAVLLSATPSSAFKIPISEESYLNVAILLQPQLQIVDEGAPSGGPSSDMFLRRTRLLVFGHITQKLSFFAETDQPNFGKNGDWNVAFFIQDAFISYEVAEKVWIDVGMLLPPLTRHVLQGAVALQAVDYHSSLVRWAPGVGKVWRDIGVQVRGFAGPLGFRAAIFNGVNGKTTPDGTVLNPDDLPRITAMARWNFFTREEDLFFQGIYFASEPRLSVGIGADYQPKAVSTESGLHDSLGTAADVFLDVPLANDQEFVFNATLFHYRQGLDNPQSGTGLYAETGWRFGKFQPLISGEYFKARVDGQDLLALKPGFNIWFQKHTLNLRTEVAVAWTGDISQARAAVTGTSQLQLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D034</accession>
    <name>Q1D034_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_5852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555803.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5852"/>
    <dbReference type="EnsemblBacteria" id="ABF91187">
        <property type="protein sequence ID" value="ABF91187"/>
        <property type="gene ID" value="MXAN_5852"/>
    </dbReference>
    <dbReference type="GeneID" id="41363091"/>
    <dbReference type="KEGG" id="mxa:MXAN_5852"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_22_1_7"/>
    <dbReference type="OMA" id="IVMPHMY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="629"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="763"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF91187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="990" mass="105599" checksum="DDA3DE2FDCC599F4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D050</accession>
    <name>Q1D050_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase, M3 (Thimet oligopeptidase) family</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_5836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5836"/>
    <dbReference type="EnsemblBacteria" id="ABF87843">
        <property type="protein sequence ID" value="ABF87843"/>
        <property type="gene ID" value="MXAN_5836"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5836"/>
    <dbReference type="eggNOG" id="COG0339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_2_1_7"/>
    <dbReference type="OMA" id="SYIAVMQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="9">
        <location>
            <begin position="246"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="687" mass="78030" checksum="958C724049BF96FD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D2</accession>
    <name>Q1D0D2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport energizing protein TolR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tolR</name>
        <name evidence="9" type="ORF">MXAN_5754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5754"/>
    <dbReference type="TCDB" id="1.A.30.2.7">
        <property type="family name" value="the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92022">
        <property type="protein sequence ID" value="ABF92022"/>
        <property type="gene ID" value="MXAN_5754"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5754"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_7"/>
    <dbReference type="OMA" id="MMTHGVK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014168">
        <property type="entry name" value="Tol-Pal_TolR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02801">
        <property type="entry name" value="tolR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="153" mass="16120" checksum="18E8C8DD9675DE03" modified="2006-07-11" version="1">MGGGNRGGGRTTMSEINVTPMVDVMLVLLIIFMVTAPLIQQGVKVNLPETKAAPVEATEKKLVLSIDAGRKVYIGDAEVALEELEQKLAANAKAQADKEVYLHADRDVPYGVVVEVMAAAQRAGIGNVGMITDPSTAGRTSNTGKGKSKEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0D4</accession>
    <name>Q1D0D4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555703.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5752"/>
    <dbReference type="EnsemblBacteria" id="ABF89258">
        <property type="protein sequence ID" value="ABF89258"/>
        <property type="gene ID" value="MXAN_5752"/>
    </dbReference>
    <dbReference type="GeneID" id="41362995"/>
    <dbReference type="KEGG" id="mxa:MXAN_5752"/>
    <dbReference type="eggNOG" id="ENOG50319K0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806142_0_0_7"/>
    <dbReference type="OMA" id="NFRDIHT"/>
    <dbReference type="OrthoDB" id="920251at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188097" evidence="1">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="38039" checksum="3CE0F4CE27CCC471" modified="2006-07-11" version="1">MNSRLLVAFLCLFAILPGCVVHEEPCCDVPRYEGDVTFRWSFGGQRCDDVRAVQGVNVVIPGEVLANDGRYNCQANGFDGIVLHRFAPGTYSFRLEGVGYGNELLYETHGTFTVDGNVTVNVDLTPTGAPPSFAYLSWLFPPNSYSPSPNCNQAGITHVEASVDGGDWARFECWEGHAANQIRTPYLDPGYHGLELVAVDRNGLPWYYFGGDILTQLGQPTSHTGSMWAIGGASVRWELRSRYGNRQTCYEAGLQRVGINFRDIHTGELVYGDVGDWHDCVDGPNESSVVVYQFLRPGRYVVEMYASARDGREYFSPNNSPVIDVVAHQFPGPNSSLPVYLIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0M0</accession>
    <name>Q1D0M0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555618.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5665"/>
    <dbReference type="EnsemblBacteria" id="ABF89783">
        <property type="protein sequence ID" value="ABF89783"/>
        <property type="gene ID" value="MXAN_5665"/>
    </dbReference>
    <dbReference type="GeneID" id="41362910"/>
    <dbReference type="KEGG" id="mxa:MXAN_5665"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054927_2_0_7"/>
    <dbReference type="OMA" id="WNVTARY"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="76"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="33396" checksum="C94B7552625215E0" modified="2006-07-11" version="1">MLPKDLIRRIRKLEIRTRKVVSDMLAGQYHSVFKGRGMAFSEVRQYQPGDEIRIIDWNVTARMDEAYVKVFTEERELTVMLVVDVSASKEFGSRERTKSEVAAEVAAQIAFSAIANNDRVGLVLFSDRVEKVVPPRKGRTHVLRLVSDILTFQPQGRGTDLAAGLNYLTRVAKRKAVTFLISDFQARDYEKPLRLVGRKHDLVPVVVADPMEEAFPRLGLVDMEDPETGERFVVDTSDPRVRGRFARAMQAARDERRKLFKKLELDHVELRAGDDHGKALANFFRARARRMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0R4</accession>
    <name>Q1D0R4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555574.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5620"/>
    <dbReference type="EnsemblBacteria" id="ABF89664">
        <property type="protein sequence ID" value="ABF89664"/>
        <property type="gene ID" value="MXAN_5620"/>
    </dbReference>
    <dbReference type="GeneID" id="41362866"/>
    <dbReference type="KEGG" id="mxa:MXAN_5620"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_151_2_7"/>
    <dbReference type="OMA" id="HFMGYLF"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="778" mass="84597" checksum="9CB6C1690C5E32F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0T7</accession>
    <name>Q1D0T7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">MXAN_5597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555551.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5597"/>
    <dbReference type="EnsemblBacteria" id="ABF88865">
        <property type="protein sequence ID" value="ABF88865"/>
        <property type="gene ID" value="MXAN_5597"/>
    </dbReference>
    <dbReference type="GeneID" id="41362843"/>
    <dbReference type="KEGG" id="mxa:MXAN_5597"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_5_7"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="12"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="206"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="42612" checksum="BC3FBFFBDE2CA5ED" modified="2006-07-11" version="1">MDQFDQNKQAAKIRVVGAGGAGCNAVNTMILSKLDRVDFIAANTDVQALAASKAPTRLQLGQTLTKGLGAGANPEMGREAALESRDQIAAVLEGADMVFVTAGMGGGTGTGAAPIIADIAKSLGCLTVGVVTKPFLFEGNKRRKQAEQGIVELKAAVDTLITIPNQRLLSLSNEPMPLLETFKRADEVLLNAVQGISDLIQYHGYINVDFADVKTIMSDKGIALMGTGNSTGDKRALIAMQQAIASPLLEDVTIDGATGLLINITGGRDMTLQEVNEALTLVHDAADSEAEIIFGSLIDENISDEVKITIIATGFVHRDAPKVRTVAPVVQVPLSRPAPSVLANAREEVASLVPTKGSGSRPLTVESAKSVSARTAVVKDAPLPLDEDQFDIPTFLRRQGQTELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0U1</accession>
    <name>Q1D0U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555547.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5593"/>
    <dbReference type="EnsemblBacteria" id="ABF92851">
        <property type="protein sequence ID" value="ABF92851"/>
        <property type="gene ID" value="MXAN_5593"/>
    </dbReference>
    <dbReference type="GeneID" id="41362839"/>
    <dbReference type="KEGG" id="mxa:MXAN_5593"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_7"/>
    <dbReference type="OMA" id="WRSVAFS"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="260" mass="27143" checksum="6E02FEBC9269BCBE" modified="2006-07-11" version="1">MEPVVATGASLNVEDRDDGVRVLTLSNPARRNALDDGLLARLDAALEPAPHVRALLVRGAGGAFCSGYDLTHLGPPGAGGRLPDDLLVECLLKLESHPAPSVALVEGAAVGAGFDLAASCDFRIGTPNAVFLMPPAKLGIVYSPEGLARAARLVGVARAKQLFLAARKLSAREALEWGLLDDCLADAETRALALCATLAGHAPLAVSGMKESFGRLARAPLEEADRARLRGLRAAAFGSEDAKEGRAAFLEKRPPRFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D127</accession>
    <name>Q1D127_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid ABC transporter, permease protein/periplasmic amino acid-binding protein, His/Glu/Gln/Arg/opine family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_5503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555461.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5503"/>
    <dbReference type="EnsemblBacteria" id="ABF89478">
        <property type="protein sequence ID" value="ABF89478"/>
        <property type="gene ID" value="MXAN_5503"/>
    </dbReference>
    <dbReference type="GeneID" id="41362757"/>
    <dbReference type="KEGG" id="mxa:MXAN_5503"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_20_4_7"/>
    <dbReference type="OMA" id="QIFMIYF"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="284"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="481" mass="52388" checksum="424D82DCD2A3E041" modified="2006-07-11" version="1">MLVLLALLSSCGAEQDSGLARVRRTGELRWGADAQGGEPYAMEDPDAPGGMRGFEVELAEALARELGVRARFVQNDWSSLVPSLERGSFDVALNGLEVTPSRSGRILFTRPYYVFHLRLLARRDDAAITGLDALKGQRVGTLANSLAWDLLQRSGVEAVPYEGVEEPYIDLEQGRVRAVLMDDIIAQRYGQPRPGLRVVGDVGEGYYAIAVRPGEEDLREALDTALGNIARSGELRAIFQRWGIDNAEQQRMVDWTDAQSREVLAPTQTARMGWGQLVLFLQAAGVTLLVSVGAMVLAIPLGVGLALTRLYGPGWAARLSTAYVELFRGTPVLLQLYVLYYGLAGVLRLDPISAAILGLGLNYAAYESEVYRAGVLAVPRGQLEAAMALGMPLRLALRRVILPQAFRVALPGVANDFIALLKDSSLVSVISVVELTKRMTITAVDVRSWLIPGALCALMYLAMSYPLSRLARHLEARLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D139</accession>
    <name>Q1D139_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autotransporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555449.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5491"/>
    <dbReference type="EnsemblBacteria" id="ABF91434">
        <property type="protein sequence ID" value="ABF91434"/>
        <property type="gene ID" value="MXAN_5491"/>
    </dbReference>
    <dbReference type="GeneID" id="41362745"/>
    <dbReference type="KEGG" id="mxa:MXAN_5491"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053049_0_0_7"/>
    <dbReference type="OMA" id="ANGGIAF"/>
    <dbReference type="OrthoDB" id="1169076at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005546">
        <property type="entry name" value="Autotransporte_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03797">
        <property type="entry name" value="Autotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188252" description="Autotransporter domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Autotransporter" evidence="2">
        <location>
            <begin position="62"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="251" mass="26896" checksum="B1907D93AA88F69D" modified="2006-07-11" version="1">MTGKLSRALAVVSLLASTSASAQEEAQALESSARDERRGLELTVGVGFQVGAGYVYREGAGLDRQVRDLKLSDAANGGIAFLLEAGYRVNSRWYVGAFGQYSHVLTKTNPYTCPEGYDCSTSQIRFGPHVQYHFAPDASFDPFVGLGVGMVLLNNKVSGPITQPAPGTVEIDSQSRGPEFVNLTLGGKWRLSDSLSFGPYLTGTYARYTTRSGTSTVNIPAVNLTQETPLEQVGDGPYGLLMLGVRGTWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D180</accession>
    <name>Q1D180_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555408.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5450"/>
    <dbReference type="EnsemblBacteria" id="ABF87623">
        <property type="protein sequence ID" value="ABF87623"/>
        <property type="gene ID" value="MXAN_5450"/>
    </dbReference>
    <dbReference type="GeneID" id="41362709"/>
    <dbReference type="KEGG" id="mxa:MXAN_5450"/>
    <dbReference type="HOGENOM" id="CLU_727064_0_0_7"/>
    <dbReference type="OMA" id="GECKWIR"/>
    <dbReference type="OrthoDB" id="746412at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="41829" checksum="123E59613BC1E6E8" modified="2006-07-11" version="1">MSFPVVKAANVKGMGWSAVLLAGLVGCGQEARKPAPEQEAIEAVKAQAQQLQPPAGCTEITMGELANGIGLTPTMYSPQPTYRGNFNNFGDPAFPDPARIRLDVNTAPGVYDLSVGGGNTFTCDRCVFGYQDEGSPAEKFFVADAGTLLLAVKVSPQQTLGALTNVTLRESVDAPPLNAPYWGSAVVPGGECRWIRFATWNTVRQDGCDPRQGSLTANLPDTTCVPNDYVASDGTLERALGTQVQGEACTKTAAASESELASTDCEQGFACTDLLSENAQCLKTCDFMAPNPGCPSGTMCGVYGLCTEQSVLEQNGFTFDPALTGEICSLEFAHYCGTEGARGVCADLNRDGKGECYPYHRARSECGPGDELGYMNYALSGGGFDRGHGFCYHDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H7</accession>
    <name>Q1D1H7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555311.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87732">
        <property type="protein sequence ID" value="ABF87732"/>
        <property type="gene ID" value="MXAN_5346"/>
    </dbReference>
    <dbReference type="GeneID" id="41362615"/>
    <dbReference type="KEGG" id="mxa:MXAN_5346"/>
    <dbReference type="eggNOG" id="COG2933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043780_0_0_7"/>
    <dbReference type="OMA" id="MAWRPLE"/>
    <dbReference type="OrthoDB" id="902245at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="FtsJ" evidence="3">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="340" mass="36656" checksum="EBBAFFBD9264F210" modified="2006-07-11" version="1">MPARTLAARPGRWLWTCRAGFEAHLFEELEWAGAEPRLLGEALVESDAVSGPPPAFARAGYQVAATLTATNPEAIADAAARAVLALPGRTPWAVQAFTPDTPRGNALAPVAEALESAVSARLPAERRIEDAQRAREAGALLVSLCVAPDEVTVVGAVHAREAVSLAAGGRRRMRRAGDAPSRAAMKLEEALDGLAFEPGRGDVCVDLGAAPGGWTQRLVSRGAKVVAVDPARLMPELTGNPRVKHVQESAFAYAPDEPADWLFCDMAWRPLEVAQLLAKWGRRGWAQHLVANIKLPMKDKNPILLRVRHTLGQEGGWEGLTVRQLYHDRDEVTVTAHKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1R3</accession>
    <name>Q1D1R3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="507"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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            <dbReference type="EMBL" id="ABF91390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="521" mass="55135" checksum="BE3A6AAD696CDA84" modified="2006-07-11" version="1"> </sequence>
</entry>
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    <accession>Q1D1X6</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
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                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4398"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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    </evidence>
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        <source>
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    <sequence length="476" mass="51446" checksum="59398E8F34DDD978" modified="2006-07-11" version="1">MMTERFPMTRPSLVTLLPLLFSLSCVSGSKIRADTEVLAANVERARRSGALRCAPVELATAEAHLDFARGELSQGNSGRADTHARTADAAVTRALELSKNCGPRQVLVRDRPEASQPQQPQQPQQPQVVVRIEETDSDGDGILDKDDPCPDQAEDMDGFQDEDGCPDPDNDNDGVLDGNDKCPLTPGVPENQGCPAEAPKDRDGDGIIDSEDKCPDQAEDKDGFQDEDGCPDLDNDGDGIVDTADKCPNEAGPMQNLGCPIVDKDGDGILDVDDKCPDEPEDKDGFQDEDGCPDLDNDGDGTPDVQDKCPNEAGPTENGGCPDKDTDGDGIVDRLDACPEEPGVQEERGCAKQYKMVVIKRDRIEIKKQILFSSGSHKIYGKQSTAVLDDVAQALRDAPWIKRIRIEGHTDSMGNDASNLRLSQRRADAVMAQLLRRGIDPGRIQAVGFGETQPIAPNSTKTGRAMNRRTEFKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1X7</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="mxa:MXAN_5193"/>
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    </dbReference>
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    </dbReference>
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            <end position="92"/>
        </location>
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            <dbReference type="Pfam" id="PF14346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="105" mass="11007" checksum="A5163189E3115C28" modified="2006-07-11" version="1">MKKLMALVAVSGTLTACGPVKSTANILDAEVQIQAARTAGAEKLAPYEWTAANLYIGKAREEVGYSDYQAGVDFAVKASRYANEAREKAMAVAGSTEPGGRTPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Z0</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="59" mass="6171" checksum="1277236AFEF77BB9" modified="2006-07-11" version="1">MAPSTRHTRPVMSSRFVQRHSRAPNPGREGGAGGVGVEESGEEGIWGAVVIALERKSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D240</accession>
    <name>Q1D240_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">MXAN_5129</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555102.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5129"/>
    <dbReference type="TCDB" id="2.A.127.1.4">
        <property type="family name" value="the enterobacterial cardiolipin transporter (clt) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88662">
        <property type="protein sequence ID" value="ABF88662"/>
        <property type="gene ID" value="MXAN_5129"/>
    </dbReference>
    <dbReference type="GeneID" id="41362413"/>
    <dbReference type="KEGG" id="mxa:MXAN_5129"/>
    <dbReference type="eggNOG" id="COG3083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030247_1_0_7"/>
    <dbReference type="OMA" id="MQSALGC"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024588">
        <property type="entry name" value="YejM_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11893">
        <property type="entry name" value="DUF3413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3413" evidence="3">
        <location>
            <begin position="92"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="291"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="662" mass="71608" checksum="C3335652F2B1ACB6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D241</accession>
    <name>Q1D241_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5128"/>
    <dbReference type="EnsemblBacteria" id="ABF86265">
        <property type="protein sequence ID" value="ABF86265"/>
        <property type="gene ID" value="MXAN_5128"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5128"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="VALWPSG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32937" checksum="4E88AC678BA33064" modified="2006-07-11" version="1">MPPRKLVRHLVWLESFAAAVEAGSIEAAAEHLGVARSVVSEHVRSLELALADGAPLLERGPGRRLQLTARGERLFAGTQTPLHQLDMKRLRDLASAEPVVRLGLNPTLSLSLVGAVARDAAAADLKLVLSFGGPHELTRQVQTRQLDLALDFTPLPTHEGVESESLLRMPFVVLAGPDNALARQAASRKSLHVKDLEGQRFVDWLRDDPYGGANSARFAAHGVTVDEVGRAESFLLLYELLRAFRACAITPDLRPMHPFPPDLHAWPLLEEEPQAVEVVALWPSGALSPGARLVLDGLRRKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D260</accession>
    <name>Q1D260_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555083.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5109"/>
    <dbReference type="EnsemblBacteria" id="ABF86189">
        <property type="protein sequence ID" value="ABF86189"/>
        <property type="gene ID" value="MXAN_5109"/>
    </dbReference>
    <dbReference type="GeneID" id="41362393"/>
    <dbReference type="KEGG" id="mxa:MXAN_5109"/>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062231_0_0_7"/>
    <dbReference type="OMA" id="VVGTCMN"/>
    <dbReference type="OrthoDB" id="861343at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="353" mass="36430" checksum="339B09E138824D2B" modified="2006-07-11" version="1">MKVFVDKVGSVTRNLGLGRTVHLASEVKAEEGAVVAVRIHGEKSTYNQLEDVHGRLVTLHAGDIVVGALGHRNALHGYEGVVPASVTVGERLHMLNMGGVIGKCTSHNHGVGLPFEAEVLGQVLEFPELMSRTGQPAHVSSGALKGTSSPVKCPVVYVVGTCMNSGKTFASAAMVRKLAQAGFRVGGAKLTGVSLMRDTLSMQDSGADVVMDFTDAGIVCTGPRTGARVARVLFSELAAENVDVIVAETGDGIMGEYGVQGILADPELKSLAGAWVLCANDPVGASGGVRHLREAYGIEVDVVAGPATDNAVGVRFVEQVVGIPARNARADAAALGGLILEKIAPKLGAGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D288</accession>
    <name>Q1D288_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555055.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5081"/>
    <dbReference type="EnsemblBacteria" id="ABF90857">
        <property type="protein sequence ID" value="ABF90857"/>
        <property type="gene ID" value="MXAN_5081"/>
    </dbReference>
    <dbReference type="GeneID" id="41362365"/>
    <dbReference type="KEGG" id="mxa:MXAN_5081"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036182_0_0_7"/>
    <dbReference type="OMA" id="YFSYMLY"/>
    <dbReference type="OrthoDB" id="1979131at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="15"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="44107" checksum="2424A257361D3ADC" modified="2006-07-11" version="1">MSTTAPPHLTDEHRPDLDWLRVVAILLLHLFHTGMMFNTWDWHVKSAQALPWLEPPMEVLHHLRMPLLMCISGLGTAFALRRRSLGTFAGDRAKRLLGPLVFGMFVVVPPQIYLERLQRGTFQGSYADFYPSVFGFVPYPAGSFSWHHLWFVAYLFIYCLLALPLFAALRTASGQVWLQRAEAWLSRGWNVVWLFLPLALNEVLLRRFPQTHALLDDPRAFIHFGLFFIGGHLLGRCPRVMEHLVARRKALLGACGLLFAVMVPPNEYAFPLETLGRTALQWLFILTALAWARACIHVRRPWLRHARERAYPFYILHQTVIVVVGFAVVDWPVGPWGLFLAVLTLTFGLTWGLCEGVARVPWLRACFGMPARSKRAAPIHAAAPVHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2F8</accession>
    <name>Q1D2F8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FG-GAP repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554986.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5010"/>
    <dbReference type="EnsemblBacteria" id="ABF91165">
        <property type="protein sequence ID" value="ABF91165"/>
        <property type="gene ID" value="MXAN_5010"/>
    </dbReference>
    <dbReference type="GeneID" id="41362294"/>
    <dbReference type="KEGG" id="mxa:MXAN_5010"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484700_0_0_7"/>
    <dbReference type="OMA" id="FWDAQKW"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="562" mass="61096" checksum="ADF80C773BB19E25" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2R4</accession>
    <name>Q1D2R4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4902"/>
    <dbReference type="EnsemblBacteria" id="ABF89269">
        <property type="protein sequence ID" value="ABF89269"/>
        <property type="gene ID" value="MXAN_4902"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4902"/>
    <dbReference type="HOGENOM" id="CLU_2451536_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="89" mass="9528" checksum="498E6040CD9F57CD" modified="2006-07-11" version="1">MMPGTRGCHTGVRVLDEALPHRVDTPACQVGKGGAFVWARVGACRRNPASAEGMSDRNATSRGRSRARVAQQDSTGLKQPHQREDVMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z1</accession>
    <name>Q1D2Z1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate ABC transporter, periplasmic sulfate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554807.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4821"/>
    <dbReference type="EnsemblBacteria" id="ABF89973">
        <property type="protein sequence ID" value="ABF89973"/>
        <property type="gene ID" value="MXAN_4821"/>
    </dbReference>
    <dbReference type="GeneID" id="41362120"/>
    <dbReference type="KEGG" id="mxa:MXAN_4821"/>
    <dbReference type="eggNOG" id="COG1613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055615_0_1_7"/>
    <dbReference type="OMA" id="KDFGGWK"/>
    <dbReference type="OrthoDB" id="1111285at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="36672" checksum="AA5715B5AD76DEC6" modified="2006-07-11" version="1">MPLALLLSVAGCSRSSSDASPDGTVTLLNVSYDPTRELYEDFNAAFAKHWAATRGQQVSIQQSHGGSGKQARSVIEGLRADVVTLALAYDVDMLHEKAQLLPADWQERLPHNSAPYTSTIVFVVRQGNPKGIRDWDDLVREDVTVITPNPKTSGGARWNYLAAWGQALRGEGGSEARAQAYVEKLFRNVPVLDSGARGATTTFAERGLGDVLLAWENEASLLIREVGQARFEVVIPSVSILAEPPVAVVDPNVDRKGTRAVAEAYLAYLYSDEGQEIAARHHFRPRSEVVAARHVSDFPGLKRLTLAEVAGDWRRAQATHFADGGLFDRIYAPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3Z3</accession>
    <name>Q1D3Z3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ORF">MXAN_4459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4459"/>
    <dbReference type="EnsemblBacteria" id="ABF90484">
        <property type="protein sequence ID" value="ABF90484"/>
        <property type="gene ID" value="MXAN_4459"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4459"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="reaction ID" value="UER00331"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="111"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="294" mass="31555" checksum="E21A163AD163F742" modified="2006-07-11" version="1">MQQQDYLDRLIALALDEDLGAAGDVTSQALIPPDYEGSAELVAKEQLVLAGLDAFVRVFKTVDPNVEVELLRRDGQEIKPKMVAARCHGRMRSLLAAERTALNIVQRAAGIATLAQQAVTSVRGSNLRVLDTRKTPPGMRTVAKEAVRMGGASNHRFGLFDGVLIKDNHIAAVGGSIAEALRRAKLNGPRLTKVEIEVTNLKQLAEAIEHGADVVMLDNMDDAQIREAVKLAAGRVPLEVSGGVTLDRLPRLAKLGIDFVSMGALTHSARAMDLSLEITAAAKRPARSKQPKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4P3</accession>
    <name>Q1D4P3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554208.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92089">
        <property type="protein sequence ID" value="ABF92089"/>
        <property type="gene ID" value="MXAN_4205"/>
    </dbReference>
    <dbReference type="GeneID" id="41361522"/>
    <dbReference type="KEGG" id="mxa:MXAN_4205"/>
    <dbReference type="eggNOG" id="ENOG502ZG0V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1545979_0_0_7"/>
    <dbReference type="OMA" id="WNLNDIR"/>
    <dbReference type="OrthoDB" id="1997954at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="21345" checksum="8FFD3FF952090B09" modified="2006-07-11" version="1">MQRANDTHAHSRISKEKSHMNTTHTPTTYSRRFVAAVTATLAVAMLLMTPGKAHAVDGDRQVTHLRVRIVTGSDDLRKASNAFAEFSYTAINGSHISISQNLNNGANWPNGSTRTVDVELPDGVLYSNMREFAIRFQSGQSNPFETGDNWNLNDIRVTAILDDGSETIIVQDSGNPYHRFKSDVNTRRAWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4T0</accession>
    <name>Q1D4T0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554171.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4168"/>
    <dbReference type="EnsemblBacteria" id="ABF85930">
        <property type="protein sequence ID" value="ABF85930"/>
        <property type="gene ID" value="MXAN_4168"/>
    </dbReference>
    <dbReference type="GeneID" id="41361486"/>
    <dbReference type="KEGG" id="mxa:MXAN_4168"/>
    <dbReference type="HOGENOM" id="CLU_1545988_0_0_7"/>
    <dbReference type="OMA" id="WAWPEPA"/>
    <dbReference type="OrthoDB" id="1879116at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="19567" checksum="AE1198B22A8B7E37" modified="2006-07-11" version="1">MSVPGIGFPGPWRLRSGAEEYELLVMRAVTALDERERVPAEHITWQLDHWLTSARRPLLEMYEALGGILPWNASSLDRARQDARVRDRLVQALERRELVALRVQRRAAAWAWPEPALPPPRPEPEVIPLARPPVEVFTLFPDPARQAEALRQAAAAGVPFCEECEKQKQRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4T7</accession>
    <name>Q1D4T7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554164.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4161"/>
    <dbReference type="EnsemblBacteria" id="ABF88689">
        <property type="protein sequence ID" value="ABF88689"/>
        <property type="gene ID" value="MXAN_4161"/>
    </dbReference>
    <dbReference type="GeneID" id="41361480"/>
    <dbReference type="KEGG" id="mxa:MXAN_4161"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091366_0_0_7"/>
    <dbReference type="OMA" id="AVRWADC"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="30928" checksum="54528B3775922F3A" modified="2006-07-11" version="1">MLADSLPPPGAAMPAPSRVEIDESNAQFRGAWRLFALGSKSGEVVERPEVYITACHVAWSMMNSAFLRAPVETEQALAASAASAARYFSAGKHGWSFVICDDWLAPSVRDNAPSILAWYGLKSEMDVTGMVADRLAPSIHPRHPFAVRPVTDTWGRQAVADINANVYDVPRHFGREAFDEDTLYTPDCQGFVACRDEEAAASTVVLRVDAAAYVALVATQPQHRRQGAAEAVMRHALAKAHQDWGTERTVLHATSAGEPVYTRMGYRPVTRFRMYMAPPPGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U8</accession>
    <name>Q1D4U8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554153.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4150"/>
    <dbReference type="EnsemblBacteria" id="ABF86066">
        <property type="protein sequence ID" value="ABF86066"/>
        <property type="gene ID" value="MXAN_4150"/>
    </dbReference>
    <dbReference type="GeneID" id="41361469"/>
    <dbReference type="KEGG" id="mxa:MXAN_4150"/>
    <dbReference type="eggNOG" id="ENOG5032SIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061334_0_0_7"/>
    <dbReference type="OMA" id="NDEIMRV"/>
    <dbReference type="OrthoDB" id="571821at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="377" mass="40834" checksum="C2D80CE19EB088D2" modified="2006-07-11" version="1">MTTAAPNAVPAPPPGCPFDAEFLPPNLRKHVDPAAPVPLRMMAAKSLVPLSPSDMVGALYMLTFDPDANVRETAAKTAAGLPDRILGSALRDEEVQPQVLGFLLGLVKGNEAYAEMLVLNASTPDDAVADVAKDCSPKLAEIIGQNQLRLLRHEDILRNLCANASAPVSLVDNVCDFAVRSGLTLMDVPQMKAARVRVFGPEAAEAPPPQGPTAEEVLQEFQEAADESAAPMEEGKRLTLAQRVMRMSIAEKIKLATLGNKEARTALIRETNKLVAVAVIRSPRITDGEVLSCAANRAMMDDVLRVIYSNREWTKNHKVKMALVKNPKVPLTVTMKFLNSFRDAELKDLSRDKNVPAAVQGFAKKLHEKKTAPKKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5D7</accession>
    <name>Q1D5D7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553966.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3956"/>
    <dbReference type="EnsemblBacteria" id="ABF86518">
        <property type="protein sequence ID" value="ABF86518"/>
        <property type="gene ID" value="MXAN_3956"/>
    </dbReference>
    <dbReference type="GeneID" id="41361288"/>
    <dbReference type="KEGG" id="mxa:MXAN_3956"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_32_7"/>
    <dbReference type="OMA" id="CIMAFFG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="386"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="577" mass="61765" checksum="FC74A93EAA721AFC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5G6</accession>
    <name>Q1D5G6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553937.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3927"/>
    <dbReference type="EnsemblBacteria" id="ABF90938">
        <property type="protein sequence ID" value="ABF90938"/>
        <property type="gene ID" value="MXAN_3927"/>
    </dbReference>
    <dbReference type="GeneID" id="41361258"/>
    <dbReference type="KEGG" id="mxa:MXAN_3927"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_1_0_7"/>
    <dbReference type="OMA" id="PGYWDVA"/>
    <dbReference type="OrthoDB" id="1345242at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="19462" checksum="79D6FD3E2BEA8E34" modified="2006-07-11" version="1">MELIDVIDTQGQVVGSAPRDQIYGQKLPHRIVHVMVERDGKVFLQRRSRHMTFMPGHLCTSAGGHVSAGEAPLEAAQRELQEELGLEGSLVPVAEFVFDDGHHRRIFLYRARMEGPLRFSEREVDGGLFLAPEELGRLLDEPCHPQLWPCLERLFPGPSADARTRWKQSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U4</accession>
    <name>Q1D5U4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553809.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3797"/>
    <dbReference type="EnsemblBacteria" id="ABF92181">
        <property type="protein sequence ID" value="ABF92181"/>
        <property type="gene ID" value="MXAN_3797"/>
    </dbReference>
    <dbReference type="GeneID" id="41361128"/>
    <dbReference type="KEGG" id="mxa:MXAN_3797"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="RDVKLNQ"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH-like_C"/>
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        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACYL_COA_DH_1"/>
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    </dbReference>
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        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
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    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="380" mass="41713" checksum="71BB755ECEA056BA" modified="2006-07-11" version="1">MNFELTDIQREIQRMTREFAAKELIPNARKWDEHHAWPTDAVKKLAELSLLGVAVPEQNGGAGLDNVCYAIAMEEISRGCASTGVIMSVNNSLYCDPIMKYGTDAQKEQFLAPFARGEKLGCFGLTEPEAGSDAAAQKTVAVRKGDEYVINGSKNWITNGPKADAIVLMTMTNKEAGHKGITAFMVPTDTPGFIRAEPDKKMGISAAWSCSMFFEDMRVPAKYMLGKEGEGFKIAMSTLDGGRIGIASQALGIARAAYEEAVRYSGERKSFGKPIREHQAIQFMIADMATEIDAARLLVWRAALQKDKGVRHSAESAMAKLYASEMASRVANKALQVHGGMGYSKEMDVERHVRDARITEIYEGTSEIQRIVIAANLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Y2</accession>
    <name>Q1D5Y2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3759"/>
    <dbReference type="EnsemblBacteria" id="ABF87412">
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        <property type="gene ID" value="MXAN_3759"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_018822_6_1_7"/>
    <dbReference type="OMA" id="PQNNREN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
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            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="55958" checksum="C632214C4D3C6B64" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D610</accession>
    <name>Q1D610_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3728"/>
    <dbReference type="EnsemblBacteria" id="ABF90002">
        <property type="protein sequence ID" value="ABF90002"/>
        <property type="gene ID" value="MXAN_3728"/>
    </dbReference>
    <dbReference type="GeneID" id="41361061"/>
    <dbReference type="KEGG" id="mxa:MXAN_3728"/>
    <dbReference type="HOGENOM" id="CLU_1382085_0_0_7"/>
    <dbReference type="OMA" id="WQARFFL"/>
    <dbReference type="OrthoDB" id="1844582at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188426" evidence="2">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="176" mass="18407" checksum="A0F849CC4F2CED2B" modified="2006-07-11" version="1">MMRTRLAFLAAAVMLASCTDGVAPYAPVHAPPAQEPVAPTDVLPPREGSEARPPPAPVEEPEVPPPPVVPRGSATVIDLGEGSRALLSVAQVDVDLTVSGVRGRHTVSVEFVPPSGLPYERRSAEVDSRVDESRTVRFSLPVAGTTVATSGMSGTWQARFFLDGAPLTAASFTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D659</accession>
    <name>Q1D659_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553695.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3677"/>
    <dbReference type="EnsemblBacteria" id="ABF89367">
        <property type="protein sequence ID" value="ABF89367"/>
        <property type="gene ID" value="MXAN_3677"/>
    </dbReference>
    <dbReference type="GeneID" id="41361012"/>
    <dbReference type="KEGG" id="mxa:MXAN_3677"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025379_2_0_7"/>
    <dbReference type="OMA" id="RAWMGSI"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187933" evidence="2">
        <location>
            <begin position="23"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="496" mass="51990" checksum="2870DE5150717FA3" modified="2006-07-11" version="1">MTRAASRRQFLRSFSFASLASAVPLFRPGASLPGSSAPLLGAPPADGPGPRVRPHHGRLRRTLGVSVVEGMFSEVFTACAGATVLTAWAIALKLGPFLVGVMTALPFFAQFVQFPAAWLTGLFGHRRVALTAVCLSRVVMFPLAVLPWLGLPFESQQRLLLTVAGVSAALSVVGNNAWVAWMGELVPRAVRGRFFGRRTALTTLAGTLASLGAGLLMDRLRPTDGVGVALPLLALGACVMGIVTTLFMASQHDPAPPGTTPPLDLKGALVPFKDDNARRVLTYQVAWNAAVGVSAPFFALHSLQNLQMTFVIMALHAASVAGVRILAAPLWGRVIDRCGAQPVLMACSLGIAAIPALWLLPSAGTLWPLLFDVVLAGALWSGHGLAIFELPLTVAPRKNRPFYLAAFATAGGLAYTAAAALGGAIAAALPTQFTLGGHVWVNLHALFVLSSVARLGAALLTARIPEPGAHPVRSVRALLSRLLPRPIPAHRAALDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D776</accession>
    <name>EFTU2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu 2</fullName>
            <shortName evidence="2">EF-Tu 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf2</name>
        <name type="ordered locus">MXAN_3298</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553342.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D776"/>
    <dbReference type="SMR" id="Q1D776"/>
    <dbReference type="STRING" id="246197.MXAN_3298"/>
    <dbReference type="EnsemblBacteria" id="ABF87514">
        <property type="protein sequence ID" value="ABF87514"/>
        <property type="gene ID" value="MXAN_3298"/>
    </dbReference>
    <dbReference type="GeneID" id="41360651"/>
    <dbReference type="KEGG" id="mxa:MXAN_3298"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_7"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000337439" description="Elongation factor Tu 2">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="396" mass="43416" checksum="3F6CAAB710AA3994" modified="2006-07-11" version="1">MAKEKFERNKPHVNIGTIGHVDHGKTSLTAAITKVLAKTGGATFLAYDLIDKAPEERERGITISTSHVEYQTSNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFLNKVDMLDDPELRELVEMEVRDLLKKYEFPGDDIPIIPGSALKALEGDTSDIGEPAILKLMEAVDSYIPTPQRATDKPFLMPVEDVFSISGRGTVATGRVERGIIKVGEEVEVVGLRPTQKTVVTGVEMFRKLLDQGMAGDNIGALVRGLKREDMERGQVLAKPGSITPHTKFKAQIYVLSKEEGGRHTPFFKGYRPQFYFRTTDVTGSVKLPENVEMVMPGDNIAIEVELITPVAMEKELRFAVREGGRTVGAGVVAEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7D7</accession>
    <name>Q1D7D7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3237"/>
    <dbReference type="EnsemblBacteria" id="ABF88518">
        <property type="protein sequence ID" value="ABF88518"/>
        <property type="gene ID" value="MXAN_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3237"/>
    <dbReference type="HOGENOM" id="CLU_955895_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="31642" checksum="C5301BCED3658AC3" modified="2006-07-11" version="1">MEAPHPSFSEAVHRGKSSHVAAGKHVRPWPCSRRGTSHMKRALMLRFVAIIALLTTTPTLANEEAESPAPIAESGPPLSREEALEQYELRHIGFDEYIAVTLSYSPLAVRSPPSRWTVPYEGKYKKPLEGAAFYQKLGRDDLVAEYQSRSATKLTLKIVGGVVMVGGLVYGIASPGVRTEDCELGPDFSACIDRNFAAGDRKRNMFLVGMGVSLVGVGLLGWGIFYNPHPIASSEARELADGHNKRLRQELGLTDVPAPAPGPRKRPYVIQARLTPVFGPNSGGLLVDGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7I5</accession>
    <name>Q1D7I5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3187"/>
    <dbReference type="EnsemblBacteria" id="ABF89281">
        <property type="protein sequence ID" value="ABF89281"/>
        <property type="gene ID" value="MXAN_3187"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3187"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_882304_0_0_7"/>
    <dbReference type="OMA" id="WAVELGC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="318" mass="35535" checksum="1D12A1B82FB8C08F" modified="2006-07-11" version="1">MEAMPRIQPINPRYRRIYQALSGPDLAVSESAGMTLEDLGLGSAEASRGDLVFGTYSPQGLERALRAYGLFQRVEERVGPLELRVVCTDPYRPRIILWSRRFYVPVADLDLRRTTGAEVGLGDALAATPLLYLDSLLLQNPGRAFDWNRPPLPGQNHPGLKLAGHILDVLLLMARRIGTEALALTPSTFAAACVYDRRFLFVDGAAQGRFLALRQAGRHLPRWLHAWAVELHCMRDEHGEAVAFKPSPMVSPLSSRLGLHFDANTWDDALQLDARRQLTLDEETLQRRFPWERMPPGPPPERVAELLGYDPLAPVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D800</accession>
    <name>Q1D800_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="4" type="ORF">MXAN_3014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553070.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3014"/>
    <dbReference type="EnsemblBacteria" id="ABF86363">
        <property type="protein sequence ID" value="ABF86363"/>
        <property type="gene ID" value="MXAN_3014"/>
    </dbReference>
    <dbReference type="GeneID" id="41360375"/>
    <dbReference type="KEGG" id="mxa:MXAN_3014"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_7"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="121"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="414" mass="43999" checksum="69F62373118987C3" modified="2006-07-11" version="1">MTALSQSEPSLSASSDSSTDALVQKAKRHLLQNYKQPPFVLARGQGARVWDMDGREYLDLIGGIATCALGHCHPEVVAAAKAQLDSLWHVSNVFYSQPQIDLAAQLTEWSGLSRAFFCNSGAEANEALLKLTRKVMKDRGTPERFEVISFDSSFHGRTLATVTATGQAKYQKGFEPLPAGFTHVPYGDLEAVRKAVGPATAAILVEPIQGEGGVRMAPLGFLVGLRALCDEHGLLLLVDEVQTGMGRTGKPFGFMHEGIVPDGISVAKALGNGLPIGAMLCKEELGASLTPGTHGSTFGGNPVAAAAANAVVRILRRPGFLDEVQEKGAYLLARARELQGRLPAGRIQAVRGQGLLVGVELDREVAPVIAQLRGEGLLVNAAGDRTLRFAPPFIVTVRELDEGLSILERVLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D834</accession>
    <name>Q1D834_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553036.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2980"/>
    <dbReference type="EnsemblBacteria" id="ABF91363">
        <property type="protein sequence ID" value="ABF91363"/>
        <property type="gene ID" value="MXAN_2980"/>
    </dbReference>
    <dbReference type="GeneID" id="41360343"/>
    <dbReference type="KEGG" id="mxa:MXAN_2980"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="MHAWTSS"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="332" mass="36028" checksum="23734885F6C41D17" modified="2006-07-11" version="1">MSQPTSPQKTTRVFGNYEVLSVLGKGGMAEVYRARVLSGPREGWTVALKRLLPALTRDPESVSLFAREAQLSKQLHHPNIVTVLDAGALEGIYFIVMELVDGRDLGQILRRCKVRGIPLPLDFAVYLGKVLLEALAYAHSATGPQGERLGIVHCDVSPSNLFISRVGEIKLGDFGVSRVLVDGKLQGGEVLGKPYYLSPESLLGEVNPEADLWAATVVLYELLTLERPFTGTTPDAVFNAIRARQYRPLRELRPDIPEALEAVVARAFAERPEDRFPTAEEFAQALTPHYDERVGTPLAIAAVVRGLFGASDEVPAAPSPSGTPPTPGTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D866</accession>
    <name>Q1D866_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553004.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2947"/>
    <dbReference type="EnsemblBacteria" id="ABF91241">
        <property type="protein sequence ID" value="ABF91241"/>
        <property type="gene ID" value="MXAN_2947"/>
    </dbReference>
    <dbReference type="GeneID" id="41360310"/>
    <dbReference type="KEGG" id="mxa:MXAN_2947"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_1_7"/>
    <dbReference type="OMA" id="LIVTEHY"/>
    <dbReference type="OrthoDB" id="1860541at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="183" mass="19844" checksum="FB09953F93C520FD" modified="2006-07-11" version="1">MPTFRLKQDQAALLVVDIQERLCAAMDRDALDRMLSRTTAAIEGARALGLPILLTEQYPQGLGPTHSLLRMRVLKDVKAVEKLEFSAAVPDVLAALGGRTQVLVAGMETHICVFQTVRDLAERGLSPFLLTDAVLSRAQEDRQVGLQLCRDAGAHVVTVEAALFDLLGRAGTPEFKQVSAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8B3</accession>
    <name>Q1D8B3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">fvmX5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552960.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2899"/>
    <dbReference type="EnsemblBacteria" id="ABF89515">
        <property type="protein sequence ID" value="ABF89515"/>
        <property type="gene ID" value="MXAN_2899"/>
    </dbReference>
    <dbReference type="GeneID" id="41360267"/>
    <dbReference type="KEGG" id="mxa:MXAN_2899"/>
    <dbReference type="eggNOG" id="ENOG5032JUN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439654_0_0_7"/>
    <dbReference type="OrthoDB" id="1632823at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045484">
        <property type="entry name" value="fvmX5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20003">
        <property type="entry name" value="fvmX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="fvmX5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="188" mass="20328" checksum="222E07ADFB6C3ED7" modified="2006-07-11" version="1">MSRAYRVSVSESLNRVVQAEDGLCSKLELLPLLSREELAGLLAAELANRGFTQEGDVALRTEADGVRIAIDVTTGDVSVTLSGEQEVELKARGELAVESPHEVEQAKLRAQDLARARLEDAADVATDKLRQQVTQKLEGRLKDLKSELDSISNKVTAEALKVRAGQLGTIEEVHEDAATGSLTIKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8F6</accession>
    <name>Q1D8F6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552917.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2856"/>
    <dbReference type="EnsemblBacteria" id="ABF90091">
        <property type="protein sequence ID" value="ABF90091"/>
        <property type="gene ID" value="MXAN_2856"/>
    </dbReference>
    <dbReference type="GeneID" id="41360226"/>
    <dbReference type="KEGG" id="mxa:MXAN_2856"/>
    <dbReference type="HOGENOM" id="CLU_194381_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027635">
        <property type="entry name" value="Lantibiotic2_lead_pep_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03898">
        <property type="entry name" value="lanti_MRSA_kill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="71" mass="7798" checksum="A168F6F20BF36511" modified="2006-07-11" version="1">MSQKKDHILRAWRDPEYFNSLSSEERAALPANPAAELELGDDLLEVITGGDFCLPGQSSAQCTPCPPRHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8K0</accession>
    <name>Q1D8K0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552873.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2806"/>
    <dbReference type="EnsemblBacteria" id="ABF91360">
        <property type="protein sequence ID" value="ABF91360"/>
        <property type="gene ID" value="MXAN_2806"/>
    </dbReference>
    <dbReference type="GeneID" id="41360182"/>
    <dbReference type="KEGG" id="mxa:MXAN_2806"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_2_7"/>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="28026" checksum="559FFDA4B3B2ECC5" modified="2006-07-11" version="1">MKFVDAHCHLEVKDYPDVVAVLDAARAAGLVHAVVVGQFHGPGNWGNALEVAAAHPEFLSPTLGIHPHEAARATEEDLATLERTCARPEVRAVGEAGLDYYYDHSPREAQAEVFRRQCALALRLGKPLVVHVRDAHDDCDAILGETGVAKGVIHCFTGDTDAARRYLDRGFLLSLSGVITYKKTEALQDAVRFAPLDRLMVETDSPYLAPVPHRGRKNQPSHVVETAKKVAELKGVTLEEVASVTTANAAALFNLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9A2</accession>
    <name>Q1D9A2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552622.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2552"/>
    <dbReference type="EnsemblBacteria" id="ABF86814">
        <property type="protein sequence ID" value="ABF86814"/>
        <property type="gene ID" value="MXAN_2552"/>
    </dbReference>
    <dbReference type="GeneID" id="41359930"/>
    <dbReference type="KEGG" id="mxa:MXAN_2552"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014572_0_0_7"/>
    <dbReference type="OMA" id="AFPFMES"/>
    <dbReference type="OrthoDB" id="1863382at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="34366" checksum="3CD6E097B226200C" modified="2006-07-11" version="1">MAWRSLRCWVSLAGTTRALHFARPFLDNRTSVVAFPFMESFTLKKAPLQVWVLSYTLLLPGLALGQTVTAKAAQASSRDSSFRARLKAAAQLYEELEYEQALKTLTQAKALATTDDERADAAMYEAIVLADLGRRSQSLRAFREALSLQPDSQLPVRVSPKVARDFDDVRKNLQSERVASAPVEPPPAPSQDRPVLEPEGTALAVATPSPAAPTPSLITSAEPELMAHESTGLRIRPLPVALLGAGVLAGGIGSYLGLRSRSDIQSARDTFSIDEQMGHLDAARGKALGANILFGVAATAAAGAVITYFLGNEATAQREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9G2</accession>
    <name>Q1D9G2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552563.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2492"/>
    <dbReference type="EnsemblBacteria" id="ABF86878">
        <property type="protein sequence ID" value="ABF86878"/>
        <property type="gene ID" value="MXAN_2492"/>
    </dbReference>
    <dbReference type="GeneID" id="41359872"/>
    <dbReference type="KEGG" id="mxa:MXAN_2492"/>
    <dbReference type="HOGENOM" id="CLU_643770_0_0_7"/>
    <dbReference type="OMA" id="GSPRWRL"/>
    <dbReference type="OrthoDB" id="1080823at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="426" mass="47953" checksum="2F97EB2258106615" modified="2006-07-11" version="1">MFQEQLSPQSQQMFGESFKERVVEAVREQIVSAIEDRLGREVRERVGEAIRHAMFERGGGMPQGYGMMPQGYGMPEPERIADALCSRLSETLRERIASVVHERIRDGIRERLAECVRAALFEQWQMSSHGFGAPDTERLAEAVRTRLLESLRERINTAAHDGVREALRERLADTLRSVMSERMPGFSPHEAERLADAIRGRLAEALHEGLVYSLRERVREALRERLSDGLRGVMTRQWGGMAAGAFDPERIAMTLQDRLSEGLRERINSAVRERVREVLRERMGEMLRGAMARHRGMMGQGGMMPQGMMMGQGMQDVERLADAIRTRLADSLRERFMSSMRSELDSALRSQLPEAVRSALGEAMRAGPSMMPMQQGGGSVDPERIASAVRESVSADVRERVGEMVRERVSEVVRNELSNGVHAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H2</accession>
    <name>Q1D9H2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEGA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2481"/>
    <dbReference type="EnsemblBacteria" id="ABF92505">
        <property type="protein sequence ID" value="ABF92505"/>
        <property type="gene ID" value="MXAN_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2481"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683009_0_0_7"/>
    <dbReference type="OMA" id="MRGCSPL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEGA" evidence="2">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="460" mass="49937" checksum="96D1654ABA00D6A0" modified="2006-07-11" version="1">MVLGGGRRRGGGDGRGRLRGDVSGQGPPVQPRFWWSRVLRQRRVLNARTATRVACFKGHPMKSALALLLLPALTLAAPPQARRVSTLLVPMDPASEASSVQMEGYMNDALSNFAGMTVRKSEELFGMPEDPEAKASLERGRKGYSESLSAFDKKEYEEAERKVRATLKELQGAAGAMRGCSPLCDALALYAAVLHLRGEVEEAKLALIDLIALSPTHELSPKRFSREFLALRVQVATSRTSQLRGSATVNSRPSGARVYVDGEVVGYTPVTLPALPIGKHLLRVERPGFRQYGQFMEVATDDAEVTAKLVPTSAYKAFDVQLDRVAGEVNRAGEKASGVAAMAQSLGLDRVMVGTLRANGEGTDLTLGYYDARTGQRLAGRRMAVQGDEFGQLKQEMERVVNHLVNNIGEKVTKSRDPLDNRGGMEDWSSEDRGGRGKAQDKKSKPGDDPLDGVSGTEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9H3</accession>
    <name>Q1D9H3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide peptidase SppA, 36K type</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sppA</name>
        <name evidence="4" type="ORF">MXAN_2480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2480"/>
    <dbReference type="EnsemblBacteria" id="ABF87886">
        <property type="protein sequence ID" value="ABF87886"/>
        <property type="gene ID" value="MXAN_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2480"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330352_0_0_7"/>
    <dbReference type="OMA" id="FYLHERN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188345" evidence="2">
        <location>
            <begin position="23"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="362"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="608"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="832" mass="88858" checksum="627367A18CCFD0AE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M8</accession>
    <name>Q1D9M8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552500.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2425"/>
    <dbReference type="EnsemblBacteria" id="ABF93135">
        <property type="protein sequence ID" value="ABF93135"/>
        <property type="gene ID" value="MXAN_2425"/>
    </dbReference>
    <dbReference type="GeneID" id="41359809"/>
    <dbReference type="KEGG" id="mxa:MXAN_2425"/>
    <dbReference type="HOGENOM" id="CLU_568277_0_0_7"/>
    <dbReference type="OMA" id="QWMLAAD"/>
    <dbReference type="OrthoDB" id="1951782at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="493" mass="50978" checksum="3DE02D4C178F1BA5" modified="2006-07-11" version="1">MLPCFRERGPGCFQGASRQFRGCPPCEQPAGRRTGSWGVRGRTDGQISAMRLWIAIAAGWGLGQLPNAPVMIPPEDPSIRDPAAAALQDANQQAAEEIEGLRPPAGYVYEAPEDASPRDFVLTPVLPDGAPPPMPGQVATEEAAQRYEPVPSPLEALQQEQAAMGGSGQQTGADGTSTGQATTGGTTSGAGGSGVTGQDVSGSGTSTGNTGTGGAGTTGPQQDGSGTPPENTVPAEQQNLGNTGATAAQTAPQQGTPTGQSGTGTTSAVPSPAPATPAFIGRSEPIGRSEPIGRSEPIGRSEPIGTPPTVAPANNPMGTGGAGTPNTNQPTPAQQMEQLNERVKQLETQLNERDADLTVRNQAVQLQVDTYGDRAVDVEQARQDRLTQIQTASQWMLAADTALEQGELDVVNALDIADNAFVDLRDSAEEDGQGTVVVHAERVRALLNLARNFVNNRDGYNARLALQEAGVQLSILRAANLERQATGNVLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9Y6</accession>
    <name>Q1D9Y6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_2317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552392.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2317"/>
    <dbReference type="EnsemblBacteria" id="ABF86360">
        <property type="protein sequence ID" value="ABF86360"/>
        <property type="gene ID" value="MXAN_2317"/>
    </dbReference>
    <dbReference type="GeneID" id="41359704"/>
    <dbReference type="KEGG" id="mxa:MXAN_2317"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_7"/>
    <dbReference type="OMA" id="HALEIMQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="276"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="523"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="670"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="10">
        <location>
            <begin position="841"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF86360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="944" mass="102527" checksum="9087517980EC12C2" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA82</accession>
    <name>Q1DA82_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2220"/>
    <dbReference type="EnsemblBacteria" id="ABF86282">
        <property type="protein sequence ID" value="ABF86282"/>
        <property type="gene ID" value="MXAN_2220"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2220"/>
    <dbReference type="HOGENOM" id="CLU_3082156_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="52" mass="6338" checksum="6DDCC362186CEE12" modified="2006-07-11" version="1">MMRLHMRRIIRRRRDMSAEAIRRDAEAITADLERLKACWRANERAERTDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAB0</accession>
    <name>Q1DAB0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2190"/>
    <dbReference type="EnsemblBacteria" id="ABF85870">
        <property type="protein sequence ID" value="ABF85870"/>
        <property type="gene ID" value="MXAN_2190"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2190"/>
    <dbReference type="HOGENOM" id="CLU_2881174_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="63" mass="6978" checksum="E6306A4F891962AB" modified="2006-07-11" version="1">MRCGPHHVDGFPPPDPQCPDAGGRSHTTWSLQECMARTVEMSLLEALGEPQPEPLKPRDFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAG7</accession>
    <name>Q1DAG7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552211.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2132"/>
    <dbReference type="EnsemblBacteria" id="ABF86398">
        <property type="protein sequence ID" value="ABF86398"/>
        <property type="gene ID" value="MXAN_2132"/>
    </dbReference>
    <dbReference type="GeneID" id="41359532"/>
    <dbReference type="KEGG" id="mxa:MXAN_2132"/>
    <dbReference type="eggNOG" id="ENOG502ZAKT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091314_1_0_7"/>
    <dbReference type="OMA" id="HAWEVKA"/>
    <dbReference type="OrthoDB" id="1189070at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="19055" checksum="E1803423B3F4B7A9" modified="2006-07-11" version="1">MLHEVGLKCGLVRVDVATIGSGCLHAWEVKADADTLRRLLVQELSYSAVFDRCTLVAGERHLERGRALVPSWWGVVLARAEGGGVVLEEVRPARDNPSPSPSPGATARLLWRPEMLALLESAGAARGVRSASKWRLLPRLLEVLPPAELRARVRQVVSPRRDAPRAAVPAQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB39</accession>
    <name>Q1DB39_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551990.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1888"/>
    <dbReference type="EnsemblBacteria" id="ABF90577">
        <property type="protein sequence ID" value="ABF90577"/>
        <property type="gene ID" value="MXAN_1888"/>
    </dbReference>
    <dbReference type="GeneID" id="41359304"/>
    <dbReference type="KEGG" id="mxa:MXAN_1888"/>
    <dbReference type="eggNOG" id="ENOG5032WT5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158539_0_0_7"/>
    <dbReference type="OMA" id="AHAGTWE"/>
    <dbReference type="OrthoDB" id="1997773at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="15430" checksum="7D1B4895789BF2FA" modified="2006-07-11" version="1">MSASPESQPAEAGLVSAHFHRVRRAKVVRLRGGAPPPPREVSRRPAHVARMLALAHHVESAIGRGLVASAADVAGQLGFTRARVTHLLDLLLLAPDIQEEVLFLEAVEGEEPLSERGLRAIAHSGTWEEQREQWREVKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB75</accession>
    <name>Q1DB75_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage tail sheath protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1852"/>
    <dbReference type="EnsemblBacteria" id="ABF90207">
        <property type="protein sequence ID" value="ABF90207"/>
        <property type="gene ID" value="MXAN_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1852"/>
    <dbReference type="eggNOG" id="COG3497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276982_0_0_7"/>
    <dbReference type="OMA" id="HAALYWP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="26210" checksum="6B1B49D892B57EAC" modified="2006-07-11" version="1">MVSYVSQEAALEGLSEHAALYWPRVKVLNPARGVFGNVEQLVVPPSGIIAGVFARNDAARPGGVYEAPAGIEAGRMFGVLGFESKECLDEKKRDIVYPRRINPLTTGPGLPRFIDGSRTLKAGGNFPYVAERRGVSFIERSLKSGLQFARHRNNTEGLRAQVRRSIATFLLAQMKNGAFRSQEPAKAYFVDVSDALNPPSVVFAGKLVARIGLATNKPAEFIVLRIAQDTRALEAELASAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBA2</accession>
    <name>Q1DBA2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90391">
        <property type="protein sequence ID" value="ABF90391"/>
        <property type="gene ID" value="MXAN_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1824"/>
    <dbReference type="HOGENOM" id="CLU_1600929_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="166" mass="18599" checksum="FBF3DB11EE54D0EB" modified="2006-07-11" version="1">MTLKHHAKHAAILGTNYIQHKTPDTTCFAPPRRDVCVSRRTTKRRANPKGTHTMKTTPKPPRLGQTTATAPQNATVTLSLSKNRYGTPQPQVDFFLPRGSSHRETSAMLYTFAASLELRTPTSERWIVQTERLEEANHGRVYLELSKGDHAEAMRGMALLNAVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBH6</accession>
    <name>Q1DBH6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89503">
        <property type="protein sequence ID" value="ABF89503"/>
        <property type="gene ID" value="MXAN_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1747"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_7"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="212" mass="23299" checksum="1D2119721F7A5E4C" modified="2006-07-11" version="1">MPEARIRMAYAAGCRELGENKVQEALGKAEAMADLTDLRWSVIGHLQTNKAKVVARFASEFQALDSLRVAEALDRRLQVEGRALDVLVQVNTSGEASKFGLPPDEVARFFRDLPAFSSLRVRGLMTLALLSADPARVRPCFTLLRELRARLREEAPAGVTMNELSMGMSGDFEWAVEEGATIVRVGQAIFGPRALPDSHYWPEPNATSDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBM8</accession>
    <name>Q1DBM8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551804.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89017">
        <property type="protein sequence ID" value="ABF89017"/>
        <property type="gene ID" value="MXAN_1693"/>
    </dbReference>
    <dbReference type="GeneID" id="41359131"/>
    <dbReference type="KEGG" id="mxa:MXAN_1693"/>
    <dbReference type="HOGENOM" id="CLU_887714_0_0_7"/>
    <dbReference type="OMA" id="VHWTVEV"/>
    <dbReference type="OrthoDB" id="1068108at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188378" evidence="1">
        <location>
            <begin position="29"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="37767" checksum="C58DCCC7497539B8" modified="2006-07-11" version="1">MHENTWKWSTVGMFLLGMGALIPTSAHACAAPNCMVGVRFPLPEDGGAVPSNIPGLVTVPPLLESVDSSTVRLLLPDGTQVPATVTPGAHQTQVLVPDAPLVPGTTYRIEAKGVCQFQPTQTESVTFTAGPALPLPTTTGTLTADTPSQGIFNVYGDSSCGDRQVEGNFTTLRFTPSPELVPFLPWVHWTVEVDGEPWSYAKHSGLTSTGEESPEPRRYEYNRQLLFLYTFCDYVGCADSYQRPPIESLPPGRHRATLKATLEHANITLPPVSVDFELSCAARVANAGMSQMSGCSDGGTEMDGGIVDGGIVDEDPLPEPVDTKKGCTQAGGGLTVLGLLSTLWLLGGRNSRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBW0</accession>
    <name>Q1DBW0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551722.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1611"/>
    <dbReference type="EnsemblBacteria" id="ABF89510">
        <property type="protein sequence ID" value="ABF89510"/>
        <property type="gene ID" value="MXAN_1611"/>
    </dbReference>
    <dbReference type="GeneID" id="41359055"/>
    <dbReference type="KEGG" id="mxa:MXAN_1611"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028594_2_0_7"/>
    <dbReference type="OMA" id="SCHTPRD"/>
    <dbReference type="OrthoDB" id="1297285at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="202"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="324" mass="34161" checksum="C9CC350CB80B6926" modified="2006-07-11" version="1">MRSHLLFLLLALSACQRNESPPPPAKAPAASAPSPRAPAVPAVTASADAAKLERGRYLVENVLACGSCHTPRDWARYGGPASGPALSGACWDDAAWELPGRVCAPNITSDPEHGIGRWTDEELMRALRDGTGRDGKTLFPLMPFLLYRELSDADAHAVIAWLRQAPATPRASARSVIPDEVYAQYKDMAAPMKTAVPEPAADDVSRGRYLATMAQCAACHAGMDEAGTPFVGGRPLPTPHGPEVVSNLTPHAHGLGAVDEAAFVARFTAFKDLAPAPARAGQVNKLTMPWGFFAGLAEADLKALYRYLRTVPAVAPAAPSASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC83</accession>
    <name>Q1DC83_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551599.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89890">
        <property type="protein sequence ID" value="ABF89890"/>
        <property type="gene ID" value="MXAN_1483"/>
    </dbReference>
    <dbReference type="GeneID" id="41358929"/>
    <dbReference type="KEGG" id="mxa:MXAN_1483"/>
    <dbReference type="HOGENOM" id="CLU_1617228_0_0_7"/>
    <dbReference type="OMA" id="ELRQHAY"/>
    <dbReference type="OrthoDB" id="1491909at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188373" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="190" mass="20879" checksum="AAFE856F2C8E0693" modified="2006-07-11" version="1">MKKVAALACLLALLGAIPSQAAELKDVFGREVPVGKGRPTLVLYANRGSRAELRQHAYSFIYELREERPIVLIHVDLRDVPGLFKGMARGEIKKSHRESIEHMRNIFRQHGEAPPPELESSLFMVADAKGEPHQAMGLKKGFGQVVAKVLSPSGRELARGPFPESARKLGQTMASASESLSTLRVVDMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ2</accession>
    <name>Q1DCJ2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_1374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1374"/>
    <dbReference type="EnsemblBacteria" id="ABF87924">
        <property type="protein sequence ID" value="ABF87924"/>
        <property type="gene ID" value="MXAN_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1374"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040423_0_0_7"/>
    <dbReference type="OMA" id="IALYEYG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188394" description="VWFA domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="82"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="44991" checksum="B28055BC9B2FDD0B" modified="2006-07-11" version="1">MENAMDRKSLSRAALSAALVTALSAALSLAEESPILKPVEKPAPAKTATPAAQAKPAPNQKPAQPAPSQQQQVPAAARPEIEVVFVLDTTGSMSGLLEGAKRKIYSIASRIAQGRPTPHLKVGLVAYRDVGDDYVTKRFDLSDDLDTVFANLRKFEAGGGGDTPEHVGRGLGEAVSKLSWSKNREVMKAIFLVGDAPPAQRNDDWDFKHWAKKAREKHIVVNTVRCGGDAETEASWRFVAKLTDGTFDSIDQGGGMVAVATPYDAELAKVNAELATKTLYTGRREVQAENMARAASMGALAPEAAAERISYMKKTRGGGAAGAPASSAPKAVGGAVDLVEAPSALDGVKADELPTELKGMSKEAQVAKVRALSEEKKALEKKAETLAAEREAWLTKNAPEKEDAFDANVMKGVKAQAARYNIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCJ6</accession>
    <name>Q1DCJ6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T2SS-T3SS_pil_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1370"/>
    <dbReference type="EnsemblBacteria" id="ABF92465">
        <property type="protein sequence ID" value="ABF92465"/>
        <property type="gene ID" value="MXAN_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1370"/>
    <dbReference type="HOGENOM" id="CLU_121896_0_0_7"/>
    <dbReference type="OMA" id="CEVICCS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032789">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13629">
        <property type="entry name" value="T2SS-T3SS_pil_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SS-T3SS_pil_N" evidence="1">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="20731" checksum="00653356C364EC01" modified="2006-07-11" version="1">MRARRRCEVICCSQGPPPGNLPWSVGDLARQAGRHEVCKDTRVSPLPQPPGVIVPAGHSPMPLLTVFPTPSQKYRSRAPRWKLWAPLALTLAASAAWAQDAATAAAPEPDYAVEAKNAQPSGLVVQVEPLHQTQFIVENAERVRVQSSAVVEASLGEPNQIMVQGLSLGVSEVLVWRQGSRQPLSVRVEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK6</accession>
    <name>Q1DCK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551477.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1360"/>
    <dbReference type="EnsemblBacteria" id="ABF90708">
        <property type="protein sequence ID" value="ABF90708"/>
        <property type="gene ID" value="MXAN_1360"/>
    </dbReference>
    <dbReference type="GeneID" id="41358806"/>
    <dbReference type="KEGG" id="mxa:MXAN_1360"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_2_0_7"/>
    <dbReference type="OMA" id="LPMCGTS"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="143"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="309" mass="34386" checksum="40B0744AC39EF887" modified="2006-07-11" version="1">MSNVHERLRRLLFLVPYVSKHPGVTVDALARALNISREDLLEELDLLTCVGRPPFNPDDYIDIYVDNDRVYVDLDQRLFAPPRLTPGEAAALAASAELLRPATGDALQSALQKLERVLPPATRERYREMYRKIDASTEAPQALGPLTRAIIERLEVTFGYASPGRSPEPRTVRPYELLSHRGQWYLQGYCHTRQDARLFRLDRMEDILVTDVSFQPPADARADVPNPARGLTDSSVRVRFSPVAAPYVKERFGQDARPLADGGVEVLVAGDSERWLTQWVLSFGGEAQVMEPASARAAVARAARASVGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCK9</accession>
    <name>PROB_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">MXAN_1357</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551474.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1DCK9"/>
    <dbReference type="SMR" id="Q1DCK9"/>
    <dbReference type="STRING" id="246197.MXAN_1357"/>
    <dbReference type="EnsemblBacteria" id="ABF87554">
        <property type="protein sequence ID" value="ABF87554"/>
        <property type="gene ID" value="MXAN_1357"/>
    </dbReference>
    <dbReference type="GeneID" id="41358803"/>
    <dbReference type="KEGG" id="mxa:MXAN_1357"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_7"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000252987" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="220"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="377" mass="39602" checksum="4E0D3391E25B51F5" modified="2006-07-11" version="1">MSSISTGRTALRSARRVVVKIGTNALTNATGRFNRQHFDALGQDLLWAAQGRELVVVSSGAIALGVERLGLPSRPRDIPGKQACAAVGQSRLVQAYEEAFAAHGKAVAQVLLTHEDVQERRRYLNVKHTLERLLTAGVVPVINENDTVSVDELKFGDNDTLAGLVAGVVDADALVLLSDVEGLYTGDPRRDAGAELLATVMQVTPEVLALATGTSSGVGTGGMSTKVRAAARASDSGIHCVITSGAVPGRLRAVLEGADVGTHFEPTGSRRSARAAWIAHALRARGTLTVDAGAREAIVTGKRSLLPSGVRGVEGDFGRGDPVDLVDAEGAVFARGLAAYDANELRRIAGHRTADIEAVLGYRYLDEAVHRDDLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL6</accession>
    <name>Q1DCL6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551467.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1DCL6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1350"/>
    <dbReference type="EnsemblBacteria" id="ABF89566">
        <property type="protein sequence ID" value="ABF89566"/>
        <property type="gene ID" value="MXAN_1350"/>
    </dbReference>
    <dbReference type="GeneID" id="41358796"/>
    <dbReference type="KEGG" id="mxa:MXAN_1350"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535093_0_0_7"/>
    <dbReference type="OMA" id="SRMKTDF"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="289"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="509" mass="55388" checksum="E998ABC43A373588" modified="2006-07-11" version="1">MSRTPPRFLNFRRTFALLIVLVVVPSAGLSGFGVVAIINERAAVEKRLEAAWRGTLESLSEELPGILASASLEPVNGQLQFILPDGQPVSEPDGAFQLEDGQVRTRDPQLAEALATVVPEAGGLPTEPTVFSLTTGGRAVLVAAERRGSVVHGVRLSVQQLEALLAERVDPRAVSSEPVRFALLPVPREPSEGGLMGRLVSEVAQARASALGPTGLAERVLSSPLQDFRLVVLPTGEDPVARASTRNRVLYGVLLGVFYLTLTFGVVYTGRALYREAQLSRMKTDFVSLVSHELRTPLTSIRMFIETLALGRLKDPAQTQEVLTLLMRETERLSIFVERVLDWARIEGGRKVYQREIVPVSELVNAAVEAFRTQRMEDGVDLTVEVSDGLPALDVDRAAVAGALLNLLQNAYKYSGPDNRRITLQVRGSGKGVDLTVEDNGVGIAPQERTRIFERFYRVDNLLTRRTEGSGLGLAITRRIIETHGGRISVQSEPGKGSRFTIHLPAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCQ3</accession>
    <name>Q1DCQ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1313"/>
    <dbReference type="EnsemblBacteria" id="ABF91456">
        <property type="protein sequence ID" value="ABF91456"/>
        <property type="gene ID" value="MXAN_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1313"/>
    <dbReference type="eggNOG" id="COG4900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1369735_0_0_7"/>
    <dbReference type="OMA" id="MWLERPG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="231" mass="26263" checksum="31A279704C88A75B" modified="2006-07-11" version="1">MWPPPGVLSRAFPLDCPPPVAQRRPNFNKTLRSLIRDISAKMPEFGHVKAGRILVVAGEARRASRGTVKPLCFRGGKSTDRTGRRKPIIRIGGKRMLYCVTLRPLFFRGSTAQARVETVIHELFHLSRRFDGTLHSGRRHAVLGRNFSRKLKPLVRRYLKLCPPELLAAMAHSGEVRILQWLERPGPAYHPGSHRRVRKVYTEEQLYSGVARMVTPKVRLARDTSARSKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD46</accession>
    <name>Q1DD46_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54 dependent DNA-binding reponse regulator Nla28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nla28</name>
        <name evidence="9" type="ORF">MXAN_1167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551287.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1DD46">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1167"/>
    <dbReference type="EnsemblBacteria" id="ABF90698">
        <property type="protein sequence ID" value="ABF90698"/>
        <property type="gene ID" value="MXAN_1167"/>
    </dbReference>
    <dbReference type="GeneID" id="41358619"/>
    <dbReference type="KEGG" id="mxa:MXAN_1167"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="ERICIMR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="142"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="48396" checksum="6EF8B6F061B3F8DC" modified="2006-07-11" version="1">MSSARILVVDDDPQARDLLQRLLGPLGAVTQAPDPRRATERIAEGAFDLVLTDMAMPEPGDGLKVLHEVKAQLPDTPVVVVTAFGNIEGALDSIQQGAFDYLAKPFDVDAILRVARRALEQKRLVEENRSLRQQVERGSLMLVGRSPALLEVYKHVARAAASNVPVLITGETGTGKEMVARALHKRSPRMNGPFIPVDCGAITESLMESELFGHAKGSFTGASGARRGVFEEASGGTLFLDEIGDVGMKVQSQLLRVLQEGEIRRVGESVPVKVDVRVVAATNKDLKTRVAEGLFREDLLYRLDVVHLHLPPLRERSEDIPALVEHFAGRHARGGVRPVVTSEANARLAAYDWPGNVRQLENVVARALALNVTGVLGPQDFPEPIGDASTPKMAGLAGDMPSLAELSRRYAAQVLQHVGGNKSEAARLLDVDRKTLYKLLEAPEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDC4</accession>
    <name>Q1DDC4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">serB</name>
        <name evidence="16" type="ORF">MXAN_1089</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551209.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1089"/>
    <dbReference type="EnsemblBacteria" id="ABF86570">
        <property type="protein sequence ID" value="ABF86570"/>
        <property type="gene ID" value="MXAN_1089"/>
    </dbReference>
    <dbReference type="GeneID" id="41358540"/>
    <dbReference type="KEGG" id="mxa:MXAN_1089"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_0_0_7"/>
    <dbReference type="OMA" id="FAAHAGC"/>
    <dbReference type="OrthoDB" id="1755462at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABF86570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="42080" checksum="AEF4AB0B523F4D73" modified="2006-07-11" version="1">MTPPLSESVLITVTGKDHPGIVSRLTGLLAEAGAELLDVEQVVVQGRLTLCLLVRLPPASGTLETLLSAAKTLGVALDFQVVEAPATPAASAHHVVTAVGRALGARELHALTQVLAGHGANVERITRLSEPHLGSVDIHISLPPGQPPDALKHALLELSMQSGGFDVALQRESLFRRGKRMVVMDMDSTLIRIEVIDELARAHGVGEQVSRITERAMHGEMDYDESLRQRVALLQGLDASVVHQLAANLPLTEGAETLVRVLKRLGYRTAVISGGFSVAAEALKARLGIDFAYSNELEIQDGKLTGRTVGRIVNAQRKAELLESLAQAEGILLDQVVAVGDGANDLLMLERAGLGIAFRAKPKLRAAADTSIAAGGLDSILYLLGLTGRELLEAGSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDV9</accession>
    <name>Q1DDV9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B12 binding domain/transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="63" first="980" last="994">
            <title>Structural basis for operator and antirepressor recognition by Myxococcus xanthus CarA repressor.</title>
            <authorList>
                <person name="Navarro-Aviles G."/>
                <person name="Jimenez M.A."/>
                <person name="Perez-Marin M.C."/>
                <person name="Gonzalez C."/>
                <person name="Rico M."/>
                <person name="Murillo F.J."/>
                <person name="Elias-Arnanz M."/>
                <person name="Padmanabhan S."/>
            </authorList>
            <dbReference type="PubMed" id="17233828"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05567.x"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 1-78</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551024.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="2JML">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-78"/>
    </dbReference>
    <dbReference type="PDBsum" id="2JML"/>
    <dbReference type="SMR" id="Q1DDV9"/>
    <dbReference type="STRING" id="246197.MXAN_0903"/>
    <dbReference type="EnsemblBacteria" id="ABF89801">
        <property type="protein sequence ID" value="ABF89801"/>
        <property type="gene ID" value="MXAN_0903"/>
    </dbReference>
    <dbReference type="GeneID" id="41358362"/>
    <dbReference type="KEGG" id="mxa:MXAN_0903"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_3_0_7"/>
    <dbReference type="OMA" id="GDVRQEC"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="EvolutionaryTrace" id="Q1DDV9"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
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    </dbReference>
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        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="162"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2JML"/>
        </source>
    </evidence>
    <sequence length="288" mass="32008" checksum="5A0B7BD68090702A" modified="2006-07-11" version="1">MTLRIRTIARMTGIREATLRAWERRYGFPRPLRSEGNNYRVYSREEVEAVRRVARLIQEEGLSVSEAIAQVKTEPPREQPEAERLRERFWSSVGALEGDEVTRVLDDAQTVMDVEAYCDGFLLPLLREMGVRLDVAREHLASALIRQRLRQVYDALSPAPAGPRALLACPSGDHHEGGLLVLGIHLKRKGWRVTMLGADTPAAALQGACVQVRPDVVALSFVRARAPEEFASVLEDALRACAPFPVVVGGLGAREHLKAIFSLGAQYAESSEELVAIWNQVRNAQNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEA2</accession>
    <name>Q1DEA2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pkn9</name>
        <name evidence="10" type="ORF">MXAN_0755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550881.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0755"/>
    <dbReference type="EnsemblBacteria" id="ABF92553">
        <property type="protein sequence ID" value="ABF92553"/>
        <property type="gene ID" value="MXAN_0755"/>
    </dbReference>
    <dbReference type="GeneID" id="41358225"/>
    <dbReference type="KEGG" id="mxa:MXAN_0755"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="RIMERMR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
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    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="589" mass="62790" checksum="21CABDEB636FAF76" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF0</accession>
    <name>Q1DEF0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550833.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0705"/>
    <dbReference type="EnsemblBacteria" id="ABF89722">
        <property type="protein sequence ID" value="ABF89722"/>
        <property type="gene ID" value="MXAN_0705"/>
    </dbReference>
    <dbReference type="GeneID" id="41358178"/>
    <dbReference type="KEGG" id="mxa:MXAN_0705"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013315_2_0_7"/>
    <dbReference type="OMA" id="SVMVMRP"/>
    <dbReference type="OrthoDB" id="1338660at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="97"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="707" mass="76263" checksum="88A91C5BD57896B9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEF7</accession>
    <name>Q1DEF7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0698"/>
    <dbReference type="EnsemblBacteria" id="ABF92822">
        <property type="protein sequence ID" value="ABF92822"/>
        <property type="gene ID" value="MXAN_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0698"/>
    <dbReference type="eggNOG" id="ENOG5033J69">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287722_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="214" mass="23770" checksum="BC8E98B177E4D2BF" modified="2006-07-11" version="1">MAPRRRAHLSARHPRAAPEAPGVHKGSRQTSLPDFFQRLRPPSHTSRRLALLCEEKRAQETFAHIPRQSFQETHRGAAKAHGGNAMFKVKQNHTFQNPMRQQIDQTTQGKQSDYAHAVGGVNQILDRHNIGISSRSQASVIDNVKKVETGERSEVNAHQREALNFGRDAFESAKKGNYKQAGVEAFGSTVNGLASMFKSIYTETPSEKQGIAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEK1</accession>
    <name>Q1DEK1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550785.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0654"/>
    <dbReference type="EnsemblBacteria" id="ABF88256">
        <property type="protein sequence ID" value="ABF88256"/>
        <property type="gene ID" value="MXAN_0654"/>
    </dbReference>
    <dbReference type="GeneID" id="41358129"/>
    <dbReference type="KEGG" id="mxa:MXAN_0654"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_3_0_7"/>
    <dbReference type="OMA" id="MMVLWER"/>
    <dbReference type="OrthoDB" id="1626703at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="167" mass="18862" checksum="DF736CFA43E1C50B" modified="2006-07-11" version="1">MPDLIAHNLIASYLSRMSMDDPLSLDRQICFPLYAAARAMTQAYAPLLSRLGLTYPQYLVLLVLWETDGETVKGMGERLYLDSGTLTPLLKRMESQGLVRRERSAEDARSVRIYLTSEGRALRRKATSIPEAMACKLGLTLEEATRLRRDVQRLFEVLSQSHVDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF44</accession>
    <name>Q1DF44_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_0459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574440">
            <id>Q1DF44</id>
        </interactant>
        <interactant intactId="EBI-1574785">
            <id>Q1DF43</id>
            <label>MXAN_0460</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550592.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DF44"/>
    <dbReference type="IntAct" id="Q1DF44">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0459"/>
    <dbReference type="EnsemblBacteria" id="ABF87143">
        <property type="protein sequence ID" value="ABF87143"/>
        <property type="gene ID" value="MXAN_0459"/>
    </dbReference>
    <dbReference type="GeneID" id="41357952"/>
    <dbReference type="KEGG" id="mxa:MXAN_0459"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027948_0_0_7"/>
    <dbReference type="OMA" id="FEPFTQR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="250"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="469" mass="51526" checksum="63B30FD831415547" modified="2006-07-11" version="1">MSPARDEPSSPPSPPMALKERAARLFREHLSAVRVRTDRLFAGLMLGQWAVGIVIALFGPRGSGAQLQAAVLVGTLLSAFPMVMARWRPGSMPTRHVVAVCQALWSSLLIYLTDGRVETHFHIFGSLAFLALYRDPWVLLSASITTVVDHVMRGTLWSHSLYGGLPPELWRFVEHAFWVAFIDVVLVYSCRGMLRELREVAVRRAELELAREREHAKARELDRALRELSGFQEHLIRVEKLAAVGQLAASVGHELRNPLAAVRNSHAYLSRKLTRDPAGAADDPRVPQFLGLMERELNACAKIISDLLDFARERPPALQPCPLRPLVDEAIGVVPQREGVRIVNDVPESLPVPHLDKEQFRQVLVNLVQNAVEAMPVGRNGVVSVVAEGGDASPWRIRVMDDGAGIPPEVLPKIFEPLFTTKTRGTGLGLAIVANMVQRHGGTISVRSEAERGSEFLIELPAAAAAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF88</accession>
    <name>Q1DF88_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0414"/>
    <dbReference type="EnsemblBacteria" id="ABF91132">
        <property type="protein sequence ID" value="ABF91132"/>
        <property type="gene ID" value="MXAN_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0414"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_5_1_7"/>
    <dbReference type="OMA" id="MQFGIEI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="150"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="379" mass="40184" checksum="249B098A5FF5BE4D" modified="2006-07-11" version="1">MSLGGILTLMGGLHAYIAVRLFVSPQLPLPWAWLGPVLVALLFLSLPVGMVASRREPTLWAQVLQWTSYVWLGAFGILLSAVVVVDLVGLGLSWSGVVTDALALARGKALVAVGVTVPAVVYAFITARGRATVERVTVPVAGLAPGLSGLKVVQISDIHVGPTLDGRWLRRVVEQVNALQPDVVAVTGDLVDGAVDALRDEVKPLSELRASLGVFYVTGNHEYYHGGPAWAAEVARLGLTVLQNEHRVVERDGARLTIAGVTDHDAGHIIPSHASRPELALRGAPQGVPRLLLAHQPRSALRVAEAGVMVDLQLSGHTHGGQVFPFMFLVKLQQPVVRGLATIAGVRVYTHRGTGYWGPPLRLGPSPEIAELTLVSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFD9</accession>
    <name>Q1DFD9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 4 pilus biogenesis operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550498.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0360"/>
    <dbReference type="EnsemblBacteria" id="ABF87810">
        <property type="protein sequence ID" value="ABF87810"/>
        <property type="gene ID" value="MXAN_0360"/>
    </dbReference>
    <dbReference type="GeneID" id="41357859"/>
    <dbReference type="KEGG" id="mxa:MXAN_0360"/>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683006_0_0_7"/>
    <dbReference type="OMA" id="GTPTLEY"/>
    <dbReference type="OrthoDB" id="1028207at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="408" mass="45154" checksum="F0C91307090840EC" modified="2006-07-11" version="1">MKTTLTRHRRRSLHGFTLLEVMIATAIGLIVLGAGLVAAMQMQRRALFEEQTMLAQVTGRTVKELIAADLQRAGSGMGNAPIVFSDTRTHPAIQMWTEPDLSMPDLTRPFPEDPAFSLPPAGHLEEEVSDVLRIHWGDTRGMVTLSPCAGTNVRADTRTFCTVENPSPRLQPTTAPTTPALLVNPARNLACHVEVTNVDAAGRRINVVPGTGIETTTTDRCGDFASEPNFWNTEPDRESWRIMPAQSATYRVNWASGTPTLEYLGPGAANWVVLSRDVERLSVRLGVAAIAQPFGGMRWFPDVANGRPNGLDACTITTCPIEQHPNELVAPATDEELRQRLFQRVREVEVTLVVRTPRQDREAFDPDQPIGVDRERFPIDGFKRRTFTFRVMLRNFAAGGLQPLLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFF9</accession>
    <name>Q1DFF9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_0340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0340"/>
    <dbReference type="EnsemblBacteria" id="ABF88333">
        <property type="protein sequence ID" value="ABF88333"/>
        <property type="gene ID" value="MXAN_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0340"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_44_7"/>
    <dbReference type="OMA" id="REEFLHV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="342"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="562" mass="61523" checksum="BCBB783CE988A75C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG7</accession>
    <name>Q1DFG7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimJ</name>
        <name evidence="2" type="ORF">MXAN_0332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550470.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0332"/>
    <dbReference type="EnsemblBacteria" id="ABF87527">
        <property type="protein sequence ID" value="ABF87527"/>
        <property type="gene ID" value="MXAN_0332"/>
    </dbReference>
    <dbReference type="GeneID" id="41357830"/>
    <dbReference type="KEGG" id="mxa:MXAN_0332"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_40_1_7"/>
    <dbReference type="OMA" id="EQFSMIR"/>
    <dbReference type="OrthoDB" id="1501005at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="22182" checksum="4EC179AE440EBEC2" modified="2006-07-11" version="1">MPAMGPDAVFNLLSTERLHLVQLPPDAAWRVLAYHEANREHVSTVSPARPANFFSVTYWRTRLAQDREDFRLDLSLRVFLLPRKQSIQLSPIIGNISLTNIRRGPLQSADLGYGLDHRYEGQGLMTEALRALCDYAFNVMGLHRLQANHLPENLRSAAVLKRLGFQVEGIARELLLIDGQWRDHVLNALIAPGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFI9</accession>
    <name>Q1DFI9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
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        <reaction evidence="1">
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    </dbReference>
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        <property type="entry name" value="GAF"/>
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    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P"/>
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        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
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        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
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        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="705"/>
        </location>
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    </feature>
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            <end position="152"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="714" mass="78416" checksum="5F49CF6028DA2AAE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFN8</accession>
    <name>Q1DFN8_MYXXD</name>
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            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0254</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_0254"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_0254"/>
    <dbReference type="eggNOG" id="ENOG5032QVZ">
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        <property type="component" value="Chromosome"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="458" mass="50726" checksum="339E54B7B0D3C014" modified="2006-07-11" version="1">MSSSAVSTPVASAPARPTSRIWAGRVLLFVGFFAALAAFPVYTPFDSKLTLPTTLSLLREGNLDLDEYAPTFESYRHGLYERDGHLYNYFPLGPSLAAVPMVVLVDGFVRLATPVGKLHPALAKPLAHWRHIYDATGGVDLDAWNGPQRLFASALTALAGVVMFMLGTALHLSRQRALLLAAVFVFCTPLLSTASRALWQHGPSLLFLTLVLLCLVRAREAPRHVAWAGIPLALAYVMRPTNSLSVLVLSLYVLWTWPRQAWKFFAGALAVAIPWVAVNLIHYGSVLAPYYEPQRLELSASRVAEALAGNLVSPARGLLVFTPVLLMSAWGLWMDLRARTFTRLHAVLVAVVALHWAAISTFPHWWAGHSYGPRFFSDMVPYLVFFLVPVVRALQWKGPEARRGLTATFAVLAVLSLVLHVHGASSRAVYRWNSLPLDVDEHPERLWDWSDPQFLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFP0</accession>
    <name>Q1DFP0_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_0252"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_0252"/>
    <dbReference type="HOGENOM" id="CLU_077132_0_0_7"/>
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    </dbReference>
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        <property type="entry name" value="Gmx_para_CXXCG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09535">
        <property type="entry name" value="Gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02264">
        <property type="entry name" value="gmx_para_CXXCG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="242" mass="26577" checksum="BB16AD540BFF3D82" modified="2006-07-11" version="1">MRFFEVLEDEATRNTGRIDGVSPWCIPSIDCTVCGGYGGLGEAYPTVDLARFAHRALLEEPRSQQALSLEAYRHLCEQLRPWVPPAAPLEPGTQLGPVVGKAKGRFGDFYFQAPWAPWIRISALEKLHAAGVRGLHGAPGDLGYRGQPAPPLHCLEVLVHGALHPTSHTPDWQAPCPRCGSHRNGYPSESAVLAASTLPENIDLFRLRDFKTVIVASERFVEAVKQLRLSDIAFRELSVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB7</accession>
    <name>Q1DGB7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine kinase PKN13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pkn13</name>
        <name evidence="4" type="ORF">MXAN_0023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92033">
        <property type="protein sequence ID" value="ABF92033"/>
        <property type="gene ID" value="MXAN_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0023"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_151_3_7"/>
    <dbReference type="OMA" id="QIMGEPL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="935" mass="98947" checksum="79DDC5B275A10EDC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-06" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>Q306N7</accession>
    <name>Q306N7_MYXXD</name>
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        <submittedName>
            <fullName evidence="10">PilR2</fullName>
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        <submittedName>
            <fullName evidence="11">Sigma-54 dependent DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pilR2</name>
        <name evidence="11" type="ORF">MXAN_5777</name>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="1998" name="Mol. Microbiol." volume="29" first="1249" last="1261">
            <title>The pilH gene encodes an ABC transporter homologue required for type IV pilus biogenesis and social gliding motility in Myxococcus xanthus.</title>
            <authorList>
                <person name="Wu S.S."/>
                <person name="Wu J."/>
                <person name="Cheng Y.L."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9767592"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1998.01013.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="24" last="33">
            <title>The Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pilus biogenesis, social motility, and development.</title>
            <authorList>
                <person name="Wall D."/>
                <person name="Kolenbrander P.E."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="9864308"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>New pil genes required for pilus assembly, S-motility, and Tgl stimulation in Myxococcus xanthus.</title>
            <authorList>
                <person name="Nudleman E."/>
                <person name="Wall D."/>
                <person name="Kaiser D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DK 1622</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="5">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK 1622</strain>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="DQ242507">
        <property type="protein sequence ID" value="ABB43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ABF87837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5777"/>
    <dbReference type="EnsemblBacteria" id="ABF87837">
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    <dbReference type="GeneID" id="41363020"/>
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    <dbReference type="OMA" id="IVELTHH"/>
    <dbReference type="OrthoDB" id="123059at2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="Sigma_54_int"/>
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    </dbReference>
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        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHFIS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="120"/>
        </location>
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            <end position="376"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF87837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="474" mass="52109" checksum="02994700FDC04C29" modified="2005-12-06" version="1">MPLFRTILVADDEPSIRHILTLVLTGHGYDVRAVADGEDALKELAARDYDVLLCDVRMPKKDGLVVLREALASHPALTAVVMSAYGSQEQALQAVAAGAFDYVQKPFKPDEIVFVLRKAEERERLVRENRRLKQASLPSTPGGHILGESPALHALLRQVARLAPVDTTVLISGESGTGKELIARELHVRSPRAPMSFVAVNCGAIPSGLIESELFGHAKGAFTDARTAKRGLFAEADGGTLFLDEVGELPLAAQVKLLRVLQEGEIRPVGENRVEKVNVRVVAATLRDLSRLVAKGDFREDLYYRLNVVNLRVPPLRERREDVPLLARAFIARFNRELNREPPVAGLTAEAEALLKSYAWPGNVRELENAMERAVLLADEPHILPANLPERLWAASPPGPHGEKPHGDPVLQGGGDLSLKRAIRELEESYIRAALRKTKGNRTRAAELLDISHRALLYKIKEYGIDPDAEAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVI2</accession>
    <name>Q1CVI2_MYXXD</name>
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    </protein>
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    </gene>
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            <taxon>Cystobacterineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88047">
        <property type="protein sequence ID" value="ABF88047"/>
        <property type="gene ID" value="MXAN_7488"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7488"/>
    <dbReference type="HOGENOM" id="CLU_2634391_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="77" mass="8704" checksum="2B84F14D592E9F4C" modified="2006-07-11" version="1">MASRWMRAAPDRRADLDACGVDDRTDVDASTACDGRMPFAFVTGPGSRSTWNGTLRMPMRRGGGHVWSWVWLRPHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVL0</accession>
    <name>Q1CVL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92562">
        <property type="protein sequence ID" value="ABF92562"/>
        <property type="gene ID" value="MXAN_7457"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7457"/>
    <dbReference type="HOGENOM" id="CLU_2524081_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="84" mass="8177" checksum="7F16E3B47261E2A4" modified="2006-07-11" version="1">MSSGGCQETDTSRTPGEAATDTGVPGWAAGTTAVDSADAGPAPTAFTACTVKVEATPLVSPLTVVVRTGLSVATLAPLGWAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVN1</accession>
    <name>Q1CVN1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heavy metal efflux pump, CzcA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557345.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7437"/>
    <dbReference type="TCDB" id="2.A.6.1.11">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90035">
        <property type="protein sequence ID" value="ABF90035"/>
        <property type="gene ID" value="MXAN_7437"/>
    </dbReference>
    <dbReference type="GeneID" id="41364586"/>
    <dbReference type="KEGG" id="mxa:MXAN_7437"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="ERKFNIM"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="915"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="958"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1057" mass="113858" checksum="45AC937E62107D98" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW71</accession>
    <name>Q1CW71_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, HAE1 family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557158.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7239"/>
    <dbReference type="EnsemblBacteria" id="ABF88606">
        <property type="protein sequence ID" value="ABF88606"/>
        <property type="gene ID" value="MXAN_7239"/>
    </dbReference>
    <dbReference type="GeneID" id="41364405"/>
    <dbReference type="KEGG" id="mxa:MXAN_7239"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_7"/>
    <dbReference type="OMA" id="DNSKMWV"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="65"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF88606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="40696" checksum="02825205E82C55D1" modified="2006-07-11" version="1">MRLVRTWSTGLAVLLLAGCRSQGDPGPQGGQAATNQPMPVEVERLAPAEVRESNEYLGALISRSSITVYPQVAGYVKSIPLKPGARVEQGEVLLVVDPRRESAGLRATQAQQAAAMAQREYAQQTRKRSAQLLKEGLQSRQDHDQAVAQAVQAEASARAIEAQVQAQEVQLGFYEVSAPFAGIVGDYPVNVGDFVTQQTALTTLDQSNTLELSVQIPVERAGTVRVGTTPVEVLDPEGRLVVSAPVFFVAPTPNATTQLVEIRGAFENTVGLRAGQFVRARVVYATREALRVPTSAVTRISSQSFVFVVRDSDAGTVAQRAPVSLGLVSGNDYEVTGGLDAGTPVVLSGIQMLRDGQPIQPKAPSRKPPPGVGGSGTDGGTPPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWL2</accession>
    <name>Q1CWL2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557017.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7098"/>
    <dbReference type="EnsemblBacteria" id="ABF92609">
        <property type="protein sequence ID" value="ABF92609"/>
        <property type="gene ID" value="MXAN_7098"/>
    </dbReference>
    <dbReference type="GeneID" id="41364273"/>
    <dbReference type="KEGG" id="mxa:MXAN_7098"/>
    <dbReference type="eggNOG" id="ENOG50315B3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1935774_0_0_7"/>
    <dbReference type="OMA" id="LKPTDVH"/>
    <dbReference type="OrthoDB" id="1796339at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="130" mass="14251" checksum="CA05CC9BF628DF8B" modified="2006-07-11" version="1">MPEKSQTERVKRAKRQGTTLELKPTDVHLASADSTHHAKKSGRRTLGKRTFADRSVSPRHAPGRGLTAKSRKLPEPEPGQSSTSRRKTLPSAAAVAYRKEGRPKKTTDTTPLKAGKVYKRAGARKTSIRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWT2</accession>
    <name>ATPA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">MXAN_7028</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABF91104" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91104.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026114085.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CWT2"/>
    <dbReference type="SMR" id="Q1CWT2"/>
    <dbReference type="STRING" id="246197.MXAN_7028"/>
    <dbReference type="EnsemblBacteria" id="ABF91104">
        <property type="protein sequence ID" value="ABF91104"/>
        <property type="gene ID" value="MXAN_7028"/>
    </dbReference>
    <dbReference type="GeneID" id="41364204"/>
    <dbReference type="KEGG" id="mxa:MXAN_7028"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_7"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000256098" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="515" mass="56104" checksum="D6DCFB2F222BF919" modified="2006-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWT3</accession>
    <name>Q1CWT3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_7027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556946.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7027"/>
    <dbReference type="EnsemblBacteria" id="ABF89045">
        <property type="protein sequence ID" value="ABF89045"/>
        <property type="gene ID" value="MXAN_7027"/>
    </dbReference>
    <dbReference type="GeneID" id="41364203"/>
    <dbReference type="KEGG" id="mxa:MXAN_7027"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554150_0_0_7"/>
    <dbReference type="OMA" id="VTWEGRQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="277"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="53684" checksum="0643F70935D05BC2" modified="2006-07-11" version="1">MSQSLLHRYSEGPSTLAAPEEARPFLGALLSAAGCGVALLDRELRPVWVNATLAALSGLEPRAHVGRPLAELWPQVAQALSPLLARALSGEDVTDTPVRGVLAPAAGERHLRVGLSPALQGGALAGVALWVRDETERFLEEQRLRARESHMRSLADVACDGHFLHDNGIVMDANRAMSQLLGYASPSEMIGRHLADYVAPEFRSQVGLVLSRGLEAPYEVVVLRRDGQRLPLEVLGRYVTWEGRQVRLVAVWDISSRKAAEELSANTEQFRHQMLGAVDAELRAPLQSLREGTRSLQRLDGLEEPQRTLVSQVARSARRMERMLQELMDFTRTRLAGGLALRPEPAVLDAVVTRVVEERRREHPGRTLHLETEGDLRGHWDTHRLAQLADNLLGSVLHQGAEDSPVTLRAVGAVGGVTLCVQSPRLTVAAEERSSLFEPFRRERSATPEGLGLGLYIARQIAVAHGGKLAVESCSGGGMSFTAWLPREGPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXA5</accession>
    <name>Q1CXA5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ORF">MXAN_6851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556776.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6851"/>
    <dbReference type="EnsemblBacteria" id="ABF86906">
        <property type="protein sequence ID" value="ABF86906"/>
        <property type="gene ID" value="MXAN_6851"/>
    </dbReference>
    <dbReference type="GeneID" id="41364040"/>
    <dbReference type="KEGG" id="mxa:MXAN_6851"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_7"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="630" mass="69500" checksum="1936FD1D44D04F46" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXB2</accession>
    <name>Q1CXB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556769.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6844"/>
    <dbReference type="EnsemblBacteria" id="ABF92548">
        <property type="protein sequence ID" value="ABF92548"/>
        <property type="gene ID" value="MXAN_6844"/>
    </dbReference>
    <dbReference type="GeneID" id="41364033"/>
    <dbReference type="KEGG" id="mxa:MXAN_6844"/>
    <dbReference type="eggNOG" id="ENOG5032BEQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966145_0_0_7"/>
    <dbReference type="OMA" id="GEWDREV"/>
    <dbReference type="OrthoDB" id="854031at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="279" mass="30075" checksum="2390C1FF149FC101" modified="2006-07-11" version="1">MTSPLHTTRRAFTWMLGTALVGGASACGLSGTGGRGVIFRMGLRTAKAPGEESPGEFTTDTGWRIRLSSGVMVLGPIYIFENASPLEPTASAPRVLQRLGQWLLPTAHAHDGHFFSGGTVLGEWDREVVFDLLEEAGEVRELGRSPGIAGLARSFSLLLQPPSRALGAEGAALGGRSMILEGTASRQETHVPFRMALDFPPPVELQRVDFVPIAAELDEGGRFVVEVQPHRWFDGAHFDRVTVPEGGGVVDLTPDTQVYRALTLNVRRYTAFAGTWEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI0</accession>
    <name>Q1CXI0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556701.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6776"/>
    <dbReference type="EnsemblBacteria" id="ABF87532">
        <property type="protein sequence ID" value="ABF87532"/>
        <property type="gene ID" value="MXAN_6776"/>
    </dbReference>
    <dbReference type="GeneID" id="41363967"/>
    <dbReference type="KEGG" id="mxa:MXAN_6776"/>
    <dbReference type="HOGENOM" id="CLU_1904478_0_0_7"/>
    <dbReference type="OMA" id="HETINSE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="133" mass="14030" checksum="649207EAB0CE2EDD" modified="2006-07-11" version="1">MTNESVNPQLTDDVSPSPAEAGIAPTPRRRTATKRKSASRTGSTRKSARKATAKRGTPRAKKTAARGKTATRKSATRKSATRATGRGARKATPRKTGTAGRTARKTGTRGTATKRTTTGGGARKSPARRTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXM5</accession>
    <name>Q1CXM5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556656.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6731"/>
    <dbReference type="EnsemblBacteria" id="ABF89325">
        <property type="protein sequence ID" value="ABF89325"/>
        <property type="gene ID" value="MXAN_6731"/>
    </dbReference>
    <dbReference type="GeneID" id="41363923"/>
    <dbReference type="KEGG" id="mxa:MXAN_6731"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_0_7"/>
    <dbReference type="OMA" id="LPPMRYK"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="31942" checksum="991AA5DCE482FEBA" modified="2006-07-11" version="1">MSALLRGIVAYPITPFTSTGRVDEVLLGKIVDDMVKAGVHAIAPLGSTGVLPYLSDDEREQVAEIVIKRVAGRVPTLVGVSSLTTERTVHHAKHAEKLGASAVMIIPMSYWKLSDAEIITHYETVAKRIAIPIAVYNNPATGGLDLSPDVISRLLKIPNVTMVKGSTGDVNRMHRLVQLCGEDVAFYNGSNPLALAAFVAGARGWCTAAPHIIPKLNIELYDAIQRGDVAAARQSFYRQLPFLQFIVAHGLPRAISAALELQGTSVGPLRAPLQALPAERVEELRRILVGLEVIPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXX5</accession>
    <name>Q1CXX5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556556.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6630"/>
    <dbReference type="EnsemblBacteria" id="ABF88157">
        <property type="protein sequence ID" value="ABF88157"/>
        <property type="gene ID" value="MXAN_6630"/>
    </dbReference>
    <dbReference type="GeneID" id="41363828"/>
    <dbReference type="KEGG" id="mxa:MXAN_6630"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032465_0_0_7"/>
    <dbReference type="OMA" id="YTVAWID"/>
    <dbReference type="OrthoDB" id="482388at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="464" mass="51789" checksum="107BBC96A942A618" modified="2006-07-11" version="1">MKPRESWGRYPQVEQQTHALVWRTDALPRKDGSLLPHGLGRSYGDSCLNAGGTLLLTSGLDRFIAFDPATGVVRCETGVSLDTILRLAAPRGWFLPVTPGTKFVTVGGAIANDVHGKNHHRGGTFGRYVRRFELLRSDGSRRVCAPDENPDWYGATIGGLGLTGLVTWAEVQLTPISNPYVLQETVPFGNLDGFLDVARASEKDYEFTMAWVDCLARGKKLGRGLLYRGNFAPPQFDGLPLARSHLSHGVGLAVPMDMPAFCLNRLSVSAFNWLYYHRQNGKPKQRLTHYDPFFYPLDAIYAWNRIYGRRGFLQFQCVVPYSTARDALKEILERSSRGGLPSFLSVLKTFGDIPSPGWLSFPREGVTLAMDFANRGEKTWKLVEDLDQLTRQAGGAVYPAKDARMSPENFAAYFPQRERFMQYVDPSFSSSFWRRVNPVSLPFSLAAERGETASPPPRSLLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY03</accession>
    <name>Q1CY03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, S9C (Acylaminoacyl-peptidase) subfamily</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_6601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CY03"/>
    <dbReference type="STRING" id="246197.MXAN_6601"/>
    <dbReference type="MEROPS" id="S09.012"/>
    <dbReference type="EnsemblBacteria" id="ABF86179">
        <property type="protein sequence ID" value="ABF86179"/>
        <property type="gene ID" value="MXAN_6601"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6601"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_0_2_7"/>
    <dbReference type="OMA" id="YKHWDEW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="521"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="730" mass="80849" checksum="57AAFF74B423E449" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY26</accession>
    <name>Q1CY26_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FecCD transport family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6575"/>
    <dbReference type="EnsemblBacteria" id="ABF85929">
        <property type="protein sequence ID" value="ABF85929"/>
        <property type="gene ID" value="MXAN_6575"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6575"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_7"/>
    <dbReference type="OMA" id="HIVWLIR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF85929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="361" mass="36187" checksum="66E73F5F98C22471" modified="2006-07-11" version="1">MSEPATSQRAHGGAGGFRASRAVMLFGGFLVLAVGCLAVAVRFGEQSISLTAALTEPTSTDAVIFWSLRLPRALLGAIVGAGLAASGATLQGLLRNPLADPFVLGVSGGAAMGATLALAVGLATVGEVAPGLGGAMARLSAPALFSFLGAGAAILFVLSASRGSASRAPYAALLTGVVFNAFASAAITLVKTLSAPDRLGEILYWLAGALGYERGGTLLLSALLQAGAIGVMWVLSARLNLLSLGDDDAASLGVPVAATRRWLLLAASASVAGAVALTGLIGFVGLIVPHLLRLAFGPDQRLLVPLSALGGAAFLVLSDLLARLAFPLFGAEPPVGVVTALLGGPLFLALLRRRVRLGTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY53</accession>
    <name>Q1CY53_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6548"/>
    <dbReference type="EnsemblBacteria" id="ABF86222">
        <property type="protein sequence ID" value="ABF86222"/>
        <property type="gene ID" value="MXAN_6548"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6548"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085140_0_0_7"/>
    <dbReference type="OMA" id="GCDPEED"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="315" mass="33770" checksum="187C31F8F7A8DA51" modified="2006-07-11" version="1">MNCHRLAITGFSLVLSSPFEITRVRSRLLHAFPTRRPSKRRLSKHPCFFAVGMKSSSRGGQRMQPNKRFAWAWVAAGVFAVSGLVAGCDPEEDPTPTPDAGQQHPDSGTRPDAGTQPDSGTQPDSGTQTDAGTEPDAGTEPEEDAGTEEDAGTVPTLPLAVDGTWIPSGYMGDGSRGGVTYDGTECLPGRAGSQRGACHKFTWTPGSDGWAGVYWQYPEGNWGDEPGFRVPDGANTVSFYAWGTEGGEIVSFMVGMNAADGFEVKEANVALTTTPTQYTIDISRVRYGQVVGGFGWTADGRTTPLVFFIDDIHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYA5</accession>
    <name>Q1CYA5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556426.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6495"/>
    <dbReference type="EnsemblBacteria" id="ABF85835">
        <property type="protein sequence ID" value="ABF85835"/>
        <property type="gene ID" value="MXAN_6495"/>
    </dbReference>
    <dbReference type="GeneID" id="41363703"/>
    <dbReference type="KEGG" id="mxa:MXAN_6495"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_0_7"/>
    <dbReference type="OMA" id="IELFEMH"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23837" checksum="9757E3C173670D7F" modified="2006-07-11" version="1">MNTGPPQGTPHIDSALHMAAPWSSPAVSRSIPFRSVRAMPSTSPGAGVRGIDHVGVTVPDLEAATAFFIEALGAEVLYDSLAKGQPPQEGEDLQRRLRFLPGSSIRAMRLLRLGNGPSLELFEYAAPEQRPPARPNDLGIQHLAVYVDDMDTALARFQAAGGEVFSSPHELPALEKGPGNAFCYARAPWGTIIEFITYPSPQPYEKQTALRRWKPPERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYD6</accession>
    <name>Q1CYD6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane protein, OMP85 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556395.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6464"/>
    <dbReference type="EnsemblBacteria" id="ABF87471">
        <property type="protein sequence ID" value="ABF87471"/>
        <property type="gene ID" value="MXAN_6464"/>
    </dbReference>
    <dbReference type="GeneID" id="41363671"/>
    <dbReference type="KEGG" id="mxa:MXAN_6464"/>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_377614_0_0_7"/>
    <dbReference type="OMA" id="NTTMLLY"/>
    <dbReference type="OrthoDB" id="470487at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187903" evidence="4">
        <location>
            <begin position="29"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="131"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Omp85" evidence="5">
        <location>
            <begin position="363"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="715" mass="78879" checksum="C3F234EA83EF24A0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYL9</accession>
    <name>Q1CYL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556312.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90190">
        <property type="protein sequence ID" value="ABF90190"/>
        <property type="gene ID" value="MXAN_6380"/>
    </dbReference>
    <dbReference type="GeneID" id="41363591"/>
    <dbReference type="KEGG" id="mxa:MXAN_6380"/>
    <dbReference type="HOGENOM" id="CLU_2936776_0_0_7"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="60" mass="6783" checksum="85AF9401B76550F2" modified="2006-07-11" version="1">MGFPQRDRERWEQAFPNHRSVEFPGVGHFFFEDTTDDVISEIRAFMSSAGPGVRVGGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYZ3</accession>
    <name>Q1CYZ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556193.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6251"/>
    <dbReference type="EnsemblBacteria" id="ABF89767">
        <property type="protein sequence ID" value="ABF89767"/>
        <property type="gene ID" value="MXAN_6251"/>
    </dbReference>
    <dbReference type="GeneID" id="41363473"/>
    <dbReference type="KEGG" id="mxa:MXAN_6251"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_24_2_7"/>
    <dbReference type="OMA" id="HCVESMQ"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="195" mass="20379" checksum="054BC948D07D6094" modified="2006-07-11" version="1">MQSRARRSNDERSATTRQALVSASRALFVEKGYAQTSTPEVVAAAAVTRGALYHHFEDKQALLRAVLEREFAELRRAIDQATPPALGAREALIAGSLAYLDAMAIPGRTRLLLVEGPAVFGHAEMMALDESSAAGSLREGLAALLGDGSLVPALASLLSAAFDRAALAISTGGDAKAYREAMLALIERVTAGAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ07</accession>
    <name>Q1CZ07_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556179.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6237"/>
    <dbReference type="EnsemblBacteria" id="ABF86805">
        <property type="protein sequence ID" value="ABF86805"/>
        <property type="gene ID" value="MXAN_6237"/>
    </dbReference>
    <dbReference type="GeneID" id="41363459"/>
    <dbReference type="KEGG" id="mxa:MXAN_6237"/>
    <dbReference type="eggNOG" id="ENOG5032QDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290994_0_0_7"/>
    <dbReference type="OrthoDB" id="2012052at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1050" mass="113828" checksum="52D5B87802459404" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ26</accession>
    <name>Q1CZ26_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, S1 (Chymotrypsin) family</fullName>
            <ecNumber evidence="2">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6216"/>
    <dbReference type="EnsemblBacteria" id="ABF86597">
        <property type="protein sequence ID" value="ABF86597"/>
        <property type="gene ID" value="MXAN_6216"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6216"/>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717113_0_0_7"/>
    <dbReference type="OMA" id="ACRCFTP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017756">
        <property type="entry name" value="TM_Gly-Cys-Arg_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03382">
        <property type="entry name" value="GC_trans_RRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="365" mass="36717" checksum="F96AF50176BF989F" modified="2006-07-11" version="1">MGLLLAAGACGPSVVPVSPETLTPARRAVVGGAPEPGFPTVAAIVPVPPFCGEPDEAARVLCTGTLVAPRVVLTAAHCVENADAPRVFSVVFAAETARASAAQRIRVVEGRLHPAWRPGVSDLGVLILASDAPVAPLAWAARAFPADGVGRLARVVGFGADGEGGSGLRRGGLSRITSVEADAFSIEAAPAMSCGGDSGGPVFIEQDGVERLVGVTSFGDLSCTTGTNSRVDVHADFIQVAIEDASRGAPVRTLVDPDVDACAQWCRAHADCPVGMACVARADGTRSCAVAGLEAGHFGPACTGAQGEHPCVKAGSACRLWLPCSEPRDATAPGGCAAAGGGNPGLIPLVLLAWSWGRGRRAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ39</accession>
    <name>Q1CZ39_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556147.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6203"/>
    <dbReference type="EnsemblBacteria" id="ABF86879">
        <property type="protein sequence ID" value="ABF86879"/>
        <property type="gene ID" value="MXAN_6203"/>
    </dbReference>
    <dbReference type="GeneID" id="41363431"/>
    <dbReference type="KEGG" id="mxa:MXAN_6203"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_0_7"/>
    <dbReference type="OMA" id="QAIKLSM"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="32032" checksum="C55C957EE0038DA9" modified="2006-07-11" version="1">MNLWTGVLPAITTPFNTDLSVDHGTVRSHVRWLVSQGCTGIIPCGSLGEGATLSQEEKAAVMRTCVDAVKVPVIPGIAALSTAEAVQLARAAEEAGCAGLMVLPPYVYSSDWREMKAHISAVLRATKLPCLLYNNPVAYKTDFTPAHLAELAAEHDNAVAVKESSTDARRVTAIRALLGDRLAVGVGVDDCLVEGVDAGARFWVAGLVNAFPAESVRLFELALAGKKQAAFELYRWFLPLLRLDTVTKFIQLIKLVQQEVGWGHERVRGPRLELAGAEREECLRVLREALANRPAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZH6</accession>
    <name>TRPD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD</name>
        <name type="ordered locus">MXAN_6062</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556011.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZH6"/>
    <dbReference type="SMR" id="Q1CZH6"/>
    <dbReference type="STRING" id="246197.MXAN_6062"/>
    <dbReference type="EnsemblBacteria" id="ABF88603">
        <property type="protein sequence ID" value="ABF88603"/>
        <property type="gene ID" value="MXAN_6062"/>
    </dbReference>
    <dbReference type="GeneID" id="41363298"/>
    <dbReference type="KEGG" id="mxa:MXAN_6062"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_7"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000325442" description="Anthranilate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <sequence length="338" mass="35226" checksum="D66CEFB23257C6C2" modified="2006-07-11" version="1">MTLKEALGKVVGRRDLTREEMTRIMGLMLAGEASPAQVGALATALKMKGETEDEILGAAEAMRACAAKLSPRADVVLDTCGTGGDGAHTFNISTAVAFVAAGAGVTVAKHGNRAVSSRCGSADVLAALGVSMERPHERVARDIDEHGVGFLFAPSHHGALRHVAQARRDMGFHSVFNLLGPLTNPAGARYQLLGTFDGKRVEQTARVLGRLGSRRAWVVHGHDGLDEISPCSATQVAELREDGTVHTFTVSPQDAGLDVVPREAIAGGDAEENAQRLRALLDGERSGLRTAVLLNAAAALVVVGLAADLRDGVRKAEQAIDSGAARNKLSALIEGGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZR9</accession>
    <name>Q1CZR9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555918.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5969"/>
    <dbReference type="EnsemblBacteria" id="ABF92455">
        <property type="protein sequence ID" value="ABF92455"/>
        <property type="gene ID" value="MXAN_5969"/>
    </dbReference>
    <dbReference type="GeneID" id="41363208"/>
    <dbReference type="KEGG" id="mxa:MXAN_5969"/>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119557_0_0_7"/>
    <dbReference type="OMA" id="RINLDML"/>
    <dbReference type="OrthoDB" id="1574819at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="20951" checksum="10295ABD9D36C8A8" modified="2006-07-11" version="1">MTVFFAWQRYGWGPSLSGPLMRRRPEPHVMDLVLFVGLQGSGKSSLYRQRFAATHVHVSKDLWPHAVRKEARQRRYIAEALAAGRPVVVDNTNPSADVRAPLIALGREFHARIIGYYFASKLEDCLARNALREGRARVPEVALRATVKQLERPRLEEGFDALFYVTLDADGGIRVQPWMEEPDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D070</accession>
    <name>Q1D070_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5816"/>
    <dbReference type="EnsemblBacteria" id="ABF91995">
        <property type="protein sequence ID" value="ABF91995"/>
        <property type="gene ID" value="MXAN_5816"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5816"/>
    <dbReference type="HOGENOM" id="CLU_1684676_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="156" mass="17223" checksum="FAFEFD1797C0B8CC" modified="2006-07-11" version="1">MRAANRRNRVHGSQRVWPRLVALLDTSRCPLAECGVFFKTSRWPGRALLARTRVFMLKNNPVMKKLVETGEERIGKLAQQLLSNEKFVAAVQTLVSRSLAAKGTLDSALRTALSAANLPSTADLEQLRSKVDDLERLLSSVEGKVDTLLAAKSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0F1</accession>
    <name>Q1D0F1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">ftsY</name>
        <name evidence="10" type="ORF">MXAN_5735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5735"/>
    <dbReference type="EnsemblBacteria" id="ABF89359">
        <property type="protein sequence ID" value="ABF89359"/>
        <property type="gene ID" value="MXAN_5735"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5735"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_1_3_7"/>
    <dbReference type="OMA" id="GIEATDY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54_N" evidence="9">
        <location>
            <begin position="166"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="261"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="262"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="269"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="351"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="415"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="463" mass="50634" checksum="7BA6F70130D772D5" modified="2006-07-11" version="1">MVLAARKLFFRKRPEEKKPPTVPPAAEKPALPAEQPRLRVELPPSEAEAARLRDAEAAHDRAEALARQRTEAAQAARTATDAAERARLEAEARTLKEREEEEKRAEYRAKKAADDEARERRKREQVEAQRLMEEERAREAAAAEEARRAEEAAARAKVEAEAGRTLAQGLDKTRNQGFMARLNGLFGQQRQVDESVLAELEEILFTADIGVRTANHLVEVAREKLKRNELKDPERIKGLIRDEVARICDLPVPRSLEGGGPPHVIMVVGVNGAGKTTTIGKLASKLTSEGKKVVLAAGDTFRAAATEQLDVWAERAQAQLVKGAEGGDPSAVIFEAVKKAKEEGADVIIADTAGRLHTKAPLMEELKKVKRVMDKALPGAPHEVLLVLDSTNGQNAIQQAKQFHEAVGVSAIALTKLDGTAKGGVVIGICDELKLPVVWVGVGEKVADLRRFEPREFVRALFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V3</accession>
    <name>Q1D0V3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555535.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5581"/>
    <dbReference type="EnsemblBacteria" id="ABF87863">
        <property type="protein sequence ID" value="ABF87863"/>
        <property type="gene ID" value="MXAN_5581"/>
    </dbReference>
    <dbReference type="GeneID" id="41362828"/>
    <dbReference type="KEGG" id="mxa:MXAN_5581"/>
    <dbReference type="eggNOG" id="ENOG502ZBWY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008731_1_0_7"/>
    <dbReference type="OMA" id="YINGEYW"/>
    <dbReference type="OrthoDB" id="688261at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="691" mass="77757" checksum="D364DCEC186B4A9C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D102</accession>
    <name>Q1D102_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555486.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5528"/>
    <dbReference type="EnsemblBacteria" id="ABF91291">
        <property type="protein sequence ID" value="ABF91291"/>
        <property type="gene ID" value="MXAN_5528"/>
    </dbReference>
    <dbReference type="GeneID" id="41362781"/>
    <dbReference type="KEGG" id="mxa:MXAN_5528"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730855_0_0_7"/>
    <dbReference type="OrthoDB" id="840281at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="422" mass="45663" checksum="0E324440A47B2311" modified="2006-07-11" version="1">MARKVAASADSALSITLARARAHWLRTQGLAEPLKGSLEEVVATTGWVRTLGGVDVYLAVRARVPGLRRADLDAAAEASQLQVIPAVRGCIYLVPRAHVPLVMRVAEEAYRKRADREHEKVGLGAKELADVAEAALVALRKGPLSTDALRKAMPAGVVRSLGEVGKKVGLSSTLPPALRHLEFEGKVERRTEGGRLDTERYLWRLTARNPFTGAKVPAAAEERNARLAALFFRQFGPATVEDFAAWSAFSQRDAKAAVARAGLVPVAVEGYSEAAYVPEDVLADLREKVPAATSVSLLPAHDLYVSSHGGPAWVTDPKHHGIEVPTWGSAKGGTLGEAAHIFVRPVLDAERLVGLWEFDPKADDVVFHTFEPLAPKRRKAVQALAEDTATFLREDFSLARSFSLDNEDSVQKRADFVKSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D162</accession>
    <name>Q1D162_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5468"/>
    <dbReference type="EnsemblBacteria" id="ABF91837">
        <property type="protein sequence ID" value="ABF91837"/>
        <property type="gene ID" value="MXAN_5468"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5468"/>
    <dbReference type="HOGENOM" id="CLU_1494708_0_0_7"/>
    <dbReference type="OMA" id="FGQGQWM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="21812" checksum="7D170968DC3A0DEF" modified="2006-07-11" version="1">MQSLAHARGAIPSRGDRARWLHPSGRMRLPVPLLAASVLFALPARADITLFPERETWLSVGPLYSAAFGADAPGTGVGGELTLNWFKGVGALGLFAQAQKMERGSARLCAGLQGTLLFGGVELGVMHETASRTRVATTGLHVAPYLAFVFGSLGVRFGIPLAGDRDIGPGGVERTRHAREVGLVLTLKLPIALSSHSVWGPLFPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D173</accession>
    <name>Q1D173_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5457"/>
    <dbReference type="EnsemblBacteria" id="ABF91594">
        <property type="protein sequence ID" value="ABF91594"/>
        <property type="gene ID" value="MXAN_5457"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5457"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813347_0_0_7"/>
    <dbReference type="OMA" id="LPFSHEW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="35173" checksum="079FF93DA6BD6143" modified="2006-07-11" version="1">MPPSSTSRQDPAVAPCPLQAGKGQVEVVVVDDRETPLSGVAVELAQGTADEALRTRTDEHGVALFEGLEEGRYRFRLLDVEPGLWRVLGRLPLPPRAAGAAPRWGSVSRPKPLSWTCEGTESLAVLAAKLGVRPSRLIDASTGQPLTPEVAPAPGTRVEVLPFSHEWTTVETGFRHVVHRIGLPLSLVVVLRDGTHHPRAHQPYLLKVWLDDEEELPAREGMTDAEGRMAQVLPARAARGEVTVSPGRDDERKVTLRFAALRATSAPEGLQERLENLGFSCGGERGQFGPKTRLAVEWFQYALGLPLSGEADEATCAALGLLHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V6</accession>
    <name>Q1D1V6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron, maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2102</name>
        <name evidence="3" type="ORF">MXAN_3607</name>
        <name evidence="2" type="ORF">MXAN_5215</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK 1622</strain>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2102"/>
    <dbReference type="EnsemblBacteria" id="ABF86578">
        <property type="protein sequence ID" value="ABF86578"/>
        <property type="gene ID" value="MXAN_5215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88048">
        <property type="protein sequence ID" value="ABF88048"/>
        <property type="gene ID" value="MXAN_3607"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89781">
        <property type="protein sequence ID" value="ABF89781"/>
        <property type="gene ID" value="MXAN_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2102"/>
    <dbReference type="KEGG" id="mxa:MXAN_3607"/>
    <dbReference type="KEGG" id="mxa:MXAN_5215"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_2_0_7"/>
    <dbReference type="OMA" id="GFHIQWR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="436" mass="49731" checksum="D6AFC3CC68919F35" modified="2006-07-11" version="1">MTKPTISPQELRARIGHRAKSAPTHRFWGLYVHVLKPEVLEAAYLEARRNGGAPGQDGITFEHIEERGRAGFLGAVAEELRTGTYRPRPYRRREIPKEGGKVRVISIPSIRDRVVQGALRLVLEPIFEADFSGSSFGARPGRSAHEAIDTVRQGLRRRRHRVVDVDLKAYFDSIRHAPLLERVARRVQDGEVLALVKQFLRSTGDRGIPQGSPLSPLLANIALNDLDHVLDRGRGFLTYARYLDDMVVLAPDSEKGRRWAARALERIRQEAEALGVSLNKEKTRTVTMTDRNASFAFLGFDFRWKRSPKTGTWYPNTNPRRKKVTEVLRRVRHVLRDSRALAVQSAVVEVNAIVRGWVNYFRWGNSYQALDRVKHHVELKVRRFAAKRAKRGGFGWKRWSKDVVYGSWGLFDDYRVRYYAILKAGSPPSGSITPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1V8</accession>
    <name>Q1D1V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555181.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5213"/>
    <dbReference type="EnsemblBacteria" id="ABF87679">
        <property type="protein sequence ID" value="ABF87679"/>
        <property type="gene ID" value="MXAN_5213"/>
    </dbReference>
    <dbReference type="GeneID" id="41362495"/>
    <dbReference type="KEGG" id="mxa:MXAN_5213"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049285_1_1_7"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="76"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="385" mass="42684" checksum="DE8237F39383B29E" modified="2006-07-11" version="1">MTNLFRNCCLAILLTSCAGTPTAREQAGPGSRREATAIVANLRRIVTPMGVERLEKIRIGGIDQWVSIRGVDRANPVLLMLHGGPGFVSMPTSWYFQRGWEEYFTVIQWDQRGAGKTYLANDPSAVAATMTAERLIADTEEMIHWARKELGKEKIFLLGHSWGSYLGLSVAQRHPEWLHAYIGMGQATDVLESERRGWRFAMDRARAAGNEEAIRELQSIAPYAAHGAALELPVVAIQRKWLGFYGGQVHGRTGGQAEAEGFALSPEYTDAELASVWTANELSEEKLFPAVLRADFSNVTRLECPMLLFNGRHDYNVSASVAAEWFERLHAPIKHLVWFENSAHEIMNEEPGKMLLSLVRYARPIAEAAGDAPKPAPRDAATGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Y1</accession>
    <name>Q1D1Y1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5189"/>
    <dbReference type="EnsemblBacteria" id="ABF89371">
        <property type="protein sequence ID" value="ABF89371"/>
        <property type="gene ID" value="MXAN_5189"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5189"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="ARIAMEI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="142" mass="15403" checksum="634B6A2A052BDB7C" modified="2006-07-11" version="1">MGSEALASGKDESPPPRGFLKGMGAERIKVLLVEDDGDSRELLAELLESEFDVKTATDGLAGLEMFEAEHPDVVVTDESLPGMCGTELAQKVKEREPRARVILVSGYTQVQGSEHCDVVLRKPIDVERLSAAVCRLGDEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D6</accession>
    <name>Q1D2D6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555008.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5032"/>
    <dbReference type="EnsemblBacteria" id="ABF90288">
        <property type="protein sequence ID" value="ABF90288"/>
        <property type="gene ID" value="MXAN_5032"/>
    </dbReference>
    <dbReference type="GeneID" id="41362317"/>
    <dbReference type="KEGG" id="mxa:MXAN_5032"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_1_7"/>
    <dbReference type="OMA" id="IMIVPMG"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="869"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1048" mass="112942" checksum="3D5D5C647CE93553" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D9</accession>
    <name>Q1D2D9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5029"/>
    <dbReference type="EnsemblBacteria" id="ABF92124">
        <property type="protein sequence ID" value="ABF92124"/>
        <property type="gene ID" value="MXAN_5029"/>
    </dbReference>
    <dbReference type="GeneID" id="41362314"/>
    <dbReference type="KEGG" id="mxa:MXAN_5029"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="16812" checksum="A6F03E8FCE330718" modified="2006-07-11" version="1">MTVPEQMASLRRAIRRLLTERLGEQTSRPFMQLLALKSIADGVRSQSAIAERMLVDAPSVSRLVARLEEDGLVKRSIAEDRRCARLELSPAGQTELNLLRDALIWTDVELLRYLTVQEMAEFKRLTVKLLTGLLQARGPVPLEGGCGPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D305</accession>
    <name>Q1D305_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2017" name="EMBO Rep." volume="18" first="1090" last="1099">
            <title>&lt;i&gt;In vivo&lt;/i&gt; structures of an intact type VI secretion system revealed by electron cryotomography.</title>
            <authorList>
                <person name="Chang Y.W."/>
                <person name="Rettberg L.A."/>
                <person name="Ortega D.R."/>
                <person name="Jensen G.J."/>
            </authorList>
            <dbReference type="PubMed" id="28487352"/>
            <dbReference type="DOI" id="10.15252/embr.201744072"/>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (24.00 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="5URW">
        <property type="method" value="EM"/>
        <property type="resolution" value="24.00 A"/>
        <property type="chains" value="1A/1C/1E/1G/1I/1K/2A/2C/2E/2G/2I/2K/3A/3C/3E/3G/3I/3K=1-164"/>
    </dbReference>
    <dbReference type="PDB" id="5URX">
        <property type="method" value="EM"/>
        <property type="resolution" value="28.00 A"/>
        <property type="chains" value="1A/1C/1E/1G/1I/1K/2A/2C/2E/2G/2I/2K/3A/3C/3E/3G/3I/3K=1-164"/>
    </dbReference>
    <dbReference type="PDBsum" id="5URW"/>
    <dbReference type="PDBsum" id="5URX"/>
    <dbReference type="SMR" id="Q1D305"/>
    <dbReference type="STRING" id="246197.MXAN_4807"/>
    <dbReference type="EnsemblBacteria" id="ABF88411">
        <property type="protein sequence ID" value="ABF88411"/>
        <property type="gene ID" value="MXAN_4807"/>
    </dbReference>
    <dbReference type="GeneID" id="41362106"/>
    <dbReference type="KEGG" id="mxa:MXAN_4807"/>
    <dbReference type="eggNOG" id="COG3516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111033_1_0_7"/>
    <dbReference type="OMA" id="RINIRYV"/>
    <dbReference type="OrthoDB" id="1278805at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35850">
        <property type="entry name" value="PTHR35850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028301">
        <property type="entry name" value="UCP028301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03358">
        <property type="entry name" value="VI_chp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="5URW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5URX"/>
        </source>
    </evidence>
    <sequence length="164" mass="17996" checksum="1CCCB3C23F565D71" modified="2006-07-11" version="1">MSKESSVAPTERVNIVYKPATGNAQEQVELPLKVLMLGDFTGQEDARPLEQRAPINVDKANFNEVMAQQNLKVTLTAADKLSADPNATMNVSLQFKNLNDFSPESVVNQVPELKKLLELRSALNALKGPLGNLPAFRKKLQALLADEDGRKALIKELGLTEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D321</accession>
    <name>Q1D321_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstA</name>
        <name evidence="9" type="ORF">MXAN_4790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4790"/>
    <dbReference type="EnsemblBacteria" id="ABF87199">
        <property type="protein sequence ID" value="ABF87199"/>
        <property type="gene ID" value="MXAN_4790"/>
    </dbReference>
    <dbReference type="GeneID" id="41362089"/>
    <dbReference type="KEGG" id="mxa:MXAN_4790"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_7"/>
    <dbReference type="OMA" id="LPGMMYD"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="65"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32222" checksum="7EBDFA4D431476BB" modified="2006-07-11" version="1">MKYTTRRAVGLGLTGLTALAAFFIVGMLALILLNIARNGARHLSWTFLTQPPSDGMMGGGIFPAIFGTAALTLLMTLAVMPVGVLTAVYLHEYAPPESRFARWVRVAVVNLAGVPSIVFGLFGLGFFILFVGGNLDRMLGYEEMHWAQPGILWASLTLAVLTLPVVIVSTEEALRAVPLEQRTASLALGATQSQTLARVVLPGALPGILTGAVLAISRGAGEVAPILFTGAAYFLPDLPTHLDSQFMHLGYHTYVMATQSPNVTEASGPLYATVLVLLALTFALNLVAVIIRTRTRRKAASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D357</accession>
    <name>Q1D357_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBS lyase HEAT-like repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554741.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4754"/>
    <dbReference type="EnsemblBacteria" id="ABF91673">
        <property type="protein sequence ID" value="ABF91673"/>
        <property type="gene ID" value="MXAN_4754"/>
    </dbReference>
    <dbReference type="GeneID" id="41362053"/>
    <dbReference type="KEGG" id="mxa:MXAN_4754"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014447_0_0_7"/>
    <dbReference type="OMA" id="HDESWRV"/>
    <dbReference type="OrthoDB" id="772324at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="659" mass="67929" checksum="31C0DF206128F667" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D360</accession>
    <name>Q1D360_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY</name>
        <name evidence="3" type="ORF">MXAN_4751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554738.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4751"/>
    <dbReference type="EnsemblBacteria" id="ABF88585">
        <property type="protein sequence ID" value="ABF88585"/>
        <property type="gene ID" value="MXAN_4751"/>
    </dbReference>
    <dbReference type="GeneID" id="41362050"/>
    <dbReference type="KEGG" id="mxa:MXAN_4751"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="AMRRSIM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13941" checksum="B4FEC0F085378105" modified="2006-07-11" version="1">MTQQIRALVVDDSQAMRRSIMYALQRLSGVVCTEAQDGAEGLKKLTQGRFDLVLTDINMPLMDGLKLISHIRQATEYRNVPIIVVTTEGAAADRERAMKLGASAYLVKPVQAKVVLDTVRDLLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3G3</accession>
    <name>Q1D3G3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crtE</name>
        <name evidence="3" type="ORF">MXAN_4644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554636.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4644"/>
    <dbReference type="EnsemblBacteria" id="ABF88210">
        <property type="protein sequence ID" value="ABF88210"/>
        <property type="gene ID" value="MXAN_4644"/>
    </dbReference>
    <dbReference type="GeneID" id="41361944"/>
    <dbReference type="KEGG" id="mxa:MXAN_4644"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_0_7"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="30890" checksum="DB2765DFA952A431" modified="2006-07-11" version="1">MATFQLNSFLAAQQARVEALLNERVARLGPSGTPPQLAEAMRYSLLAGGKRLRPVLCLAFADLVARGSAVSAVAGDAACALEYVHTYSLVHDDLPAMDNDDYRRGRLTNHKVYGEAMAILAGDALLTEAFTLVASGPESMRAALCRELAVASGAAGMVGGQVLDTAEDRPSALDYLIRMHRMKTGALIRAACRMGVLASGGDADALARADTYGDAVGLAFQIADDVLDVTATAAELGKPAGADAAAGRFTFPAVVGLEASRTLADQKVAEAIAAVRPLEGEDGPLAALARYTVERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3H3</accession>
    <name>Q1D3H3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like nuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2019" name="Cell" volume="179" first="1512" last="1524.e15">
            <title>ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches.</title>
            <authorList>
                <person name="Osorio-Valeriano M."/>
                <person name="Altegoer F."/>
                <person name="Steinchen W."/>
                <person name="Urban S."/>
                <person name="Liu Y."/>
                <person name="Bange G."/>
                <person name="Thanbichler M."/>
            </authorList>
            <dbReference type="PubMed" id="31835030"/>
            <dbReference type="DOI" id="10.1016/j.cell.2019.11.015"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 289-489</scope>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6RYK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=289-489"/>
    </dbReference>
    <dbReference type="PDBsum" id="6RYK"/>
    <dbReference type="SMR" id="Q1D3H3"/>
    <dbReference type="STRING" id="246197.MXAN_4634"/>
    <dbReference type="EnsemblBacteria" id="ABF89778">
        <property type="protein sequence ID" value="ABF89778"/>
        <property type="gene ID" value="MXAN_4634"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4634"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035125_0_0_7"/>
    <dbReference type="OMA" id="MDAEHRV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="295"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6RYK"/>
        </source>
    </evidence>
    <sequence length="489" mass="50811" checksum="CEB19FE707FC4217" modified="2006-07-11" version="1">MRARGLFRGATMDAEHRVDGQDGTAGAGPEGGSQAPSGQDGGQGGAVSAELHASGGPSGPQGEHRREDASPESGGEHRAEGTPPAEGSEQRAEGTPAAEGSEQRAEGKPSEQGVAQRAEDTPSEQGEPQNAGSAQGQGGEPPVASGDTQGEGERPHNAGGEAPGSADASGSEGSKDQAGSQEGGLQAEGTTSQGQAEPPAKDASHAQGEHQAVSDSHGQDGSESGGRSVANEEARAEQSPSDGEARVTPGLDERPQGAFWTGEADGDKSGDSDEASREDVLPEPEQRLSGRVTTVLLPLEKLQDESAFKLRPEGDVSGLATDIARLGQLFPVDVRPAGEDRYQLVCGFRRVAALRFLKRDAVQARIHLRLSDEDALVMSLAEAIHATPVGPEVLEAKRDELEAQGRLSAAVRDMLEKALATEDTLAPEGVEEEIDADELAQEVAQRLGAINQDLSLLADVFAALDESRKAELLMQLRYSSELVTYLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L5</accession>
    <name>Q1D3L5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4590"/>
    <dbReference type="EnsemblBacteria" id="ABF88498">
        <property type="protein sequence ID" value="ABF88498"/>
        <property type="gene ID" value="MXAN_4590"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4590"/>
    <dbReference type="HOGENOM" id="CLU_841522_0_0_7"/>
    <dbReference type="OMA" id="TEYRVWR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="342" mass="36711" checksum="EC6C0E9BAE458F65" modified="2006-07-11" version="1">MPERATFAEGWAMRSDLRRLTWACVLLTCGLSLAEPLVGPSVGRGDALLAEGTRLYNKRKHKDAAEVLLQATRANPSLLPAYLGLARARMGAKDVPGACAAYRAYVRSAPDIQDRTKAQRELALCERKLKAARRKKRNKVPPDMTARHVELKAGFFAALEEGRLVGPGAAGETLRTLVSEGYLGTDLGDMAARLSAASQATTNELHQRALAGEALPTARLRESGALFDLARDTGEPSAKAAAQAPFLEGLAALQSGDSTGAQRLFAKAASAAPERTEYRVWRAAALQRAGDLDGALTVLETDLPQDARTDVLRAASAQRKSPEAGARELERILFQRYAPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D435</accession>
    <name>Q1D435_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554416.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4417"/>
    <dbReference type="EnsemblBacteria" id="ABF89025">
        <property type="protein sequence ID" value="ABF89025"/>
        <property type="gene ID" value="MXAN_4417"/>
    </dbReference>
    <dbReference type="GeneID" id="41361730"/>
    <dbReference type="KEGG" id="mxa:MXAN_4417"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079365_0_0_7"/>
    <dbReference type="OMA" id="TRGHDLP"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="127"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="267" mass="29630" checksum="CAC0BDE03A417B7E" modified="2006-07-11" version="1">MSASSSSDILARFEKLVRRRAVSSDPAWRMESGEGFLRALGPSPSPFDNSLCWAHTDEENVEAVIAAQMAYFRSLGRAFMWKVYTQDSPSDLETRLLRAGFEVQAHVTLVVLDTARSQPATALPPGVEIRRVDDATGLAAAMKVQEVVWSQDCQWLHDALKEELRTQPDTLSIFVGWSEGRPVCSSWIRIEEGAPFASLWGGSVLPDFRGRGFYRAMVAARAEVARQRDIAHLYVEAGDMSRPILERLGFQALSQVAKCIYRPPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B5</accession>
    <name>Q1D4B5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554336.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4334"/>
    <dbReference type="EnsemblBacteria" id="ABF88181">
        <property type="protein sequence ID" value="ABF88181"/>
        <property type="gene ID" value="MXAN_4334"/>
    </dbReference>
    <dbReference type="GeneID" id="41361646"/>
    <dbReference type="KEGG" id="mxa:MXAN_4334"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058234_0_1_7"/>
    <dbReference type="OMA" id="YWTHNDS"/>
    <dbReference type="OrthoDB" id="1688876at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="32710" checksum="4B41C463D85C96D2" modified="2006-07-11" version="1">MPRRLLLAVLAGVLGACSRSKPPPAPPPPEATNQVPAQGVPGCTLYGEPQRFGTVPDVLPELSGLAASQRHPGAFWAHNDSGNGFELFAMDAKGGILARLTLTGATPRDIEDVTVGPCASGASRRCVYLADIGDNFARREQVRLYRLPEPEALEDATVPVDVLSFMYPGGPRDAESVIIDARSGRLAVITKTLDSLGDVFALDGLSAETPIQARKLGTLTAPLGMDRATTAASLHPSGERLLLRTYSRAYELRRPGAARLEDLLQGELVEVPSGSQAQAEAITFVQDGNGYLLGTEFTGQPLWLIGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B9</accession>
    <name>Q1D4B9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic serine protease, DO/DeqQ family</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554332.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4330"/>
    <dbReference type="EnsemblBacteria" id="ABF92238">
        <property type="protein sequence ID" value="ABF92238"/>
        <property type="gene ID" value="MXAN_4330"/>
    </dbReference>
    <dbReference type="GeneID" id="41361642"/>
    <dbReference type="KEGG" id="mxa:MXAN_4330"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_7"/>
    <dbReference type="OMA" id="RALFQIQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188351" evidence="4">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="376"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="477" mass="49541" checksum="82481BD68DC72C31" modified="2006-07-11" version="1">MFSRFFSLCLVLALAPVAAAAEGPLDAWLSARAREHAAWFAAQAAGVEGQTGSLGLWRERAEGDPGIPHFVPPSSLAPLIRAVEASVVNITTVGPRAGGLEGMKKSTGSGFVLTPDGLVVTNNHVVASAQQIAVRLADGREFAASVVGRDASTDVALLRLSGVDLGKLPAVYLGDSDRMAVGDWVVAIGNPFGLDHSVSHGMISAKERVLGVGQFDDFIQTDALINPGNSGGPLFNMKGEVVGVNTAIISQGQGIGFAVPSNLVKELLPNLRENGKLARGWLGVVINDDGSNGGGERQAPLVKDVYKGSPAAAVGIRPGDRLVAVNGRPIGSYLQLLRKVALLAPGTEARLSLTRGTETQEVTVRLVARPAQEATEGLIQRTASEEEMGLVIRDLTPEVAAPLGETAWSGVLVSGVTPRSPADSAGLRAGDVVTEVNRRRVKDVAGVRAALGKGSAGVSILLRVKRGEALQYIAIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4F7</accession>
    <name>Q1D4F7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554294.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4291"/>
    <dbReference type="EnsemblBacteria" id="ABF86863">
        <property type="protein sequence ID" value="ABF86863"/>
        <property type="gene ID" value="MXAN_4291"/>
    </dbReference>
    <dbReference type="GeneID" id="41361602"/>
    <dbReference type="KEGG" id="mxa:MXAN_4291"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_16_2_7"/>
    <dbReference type="OMA" id="LEWGILN"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="86" mass="9568" checksum="7F1F9376E0532E3D" modified="2006-07-11" version="1">MNRDDLLDVLTRYVANELLDGDAEDLDSSTPLLELGVLNSLETARMMGFVQKKYGITIPSESLKVENLQTISAIADLVYDARPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4G4</accession>
    <name>Q1D4G4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554287.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4284"/>
    <dbReference type="EnsemblBacteria" id="ABF88534">
        <property type="protein sequence ID" value="ABF88534"/>
        <property type="gene ID" value="MXAN_4284"/>
    </dbReference>
    <dbReference type="GeneID" id="41361597"/>
    <dbReference type="KEGG" id="mxa:MXAN_4284"/>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104584_0_0_7"/>
    <dbReference type="OMA" id="PVPWPCE"/>
    <dbReference type="OrthoDB" id="1318547at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="206" mass="23634" checksum="70E22FCB629E5E94" modified="2006-07-11" version="1">MSLIERLRDSRRHEERPSQKASRAARTSSAAPRPTVNRDLRTQLLRLDRIDSTLRSAWVATEFKDRALERKLNALTEAGIDWLRETIKVHGWPGHRLVGRSGAAAAWRLIQHADCSLAFQKRCLKLLRDAAARADVPIQQVAYLTDVVRMREGKKQLYGTKFRKVKGELVPYPIEKEAGVDLRRKEMNLPSLAAYARKIRRTFQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H7</accession>
    <name>Q1D4H7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554274.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4271"/>
    <dbReference type="EnsemblBacteria" id="ABF92886">
        <property type="protein sequence ID" value="ABF92886"/>
        <property type="gene ID" value="MXAN_4271"/>
    </dbReference>
    <dbReference type="GeneID" id="41361586"/>
    <dbReference type="KEGG" id="mxa:MXAN_4271"/>
    <dbReference type="HOGENOM" id="CLU_1401177_0_0_7"/>
    <dbReference type="OMA" id="NALYWAY"/>
    <dbReference type="OrthoDB" id="1401725at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="194" mass="21244" checksum="539FC85983E3226B" modified="2006-07-11" version="1">MRLDPDSGAIEGEWLLLVHHSPGRLRVRASCFRDDSAVADRVRGELGETQGVFGTVHSPLTGSLLVEYSPDAADVESLLAAIVDTAGLDGIVDAKFMAKSRRAPAEHLVRGARWLDGRVRELTGAGLYELIPVVLTATGIYSLVANPSQKGWLPRWDNALYWAYSVFRDGVREQELEDAARVSGTVPFRPRPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Q8</accession>
    <name>Q1D4Q8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ORF">MXAN_4190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554193.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4190"/>
    <dbReference type="EnsemblBacteria" id="ABF90087">
        <property type="protein sequence ID" value="ABF90087"/>
        <property type="gene ID" value="MXAN_4190"/>
    </dbReference>
    <dbReference type="GeneID" id="41361508"/>
    <dbReference type="KEGG" id="mxa:MXAN_4190"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_7"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="725"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="526"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="338"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="801" mass="87445" checksum="BEB5626CEC1277AC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D560</accession>
    <name>Q1D560_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglycosylase SLT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554042.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4034"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92945">
        <property type="protein sequence ID" value="ABF92945"/>
        <property type="gene ID" value="MXAN_4034"/>
    </dbReference>
    <dbReference type="GeneID" id="41361365"/>
    <dbReference type="KEGG" id="mxa:MXAN_4034"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013746_1_0_7"/>
    <dbReference type="OMA" id="WLHYDAG"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="YfiO" evidence="4">
        <location>
            <begin position="324"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="547"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="711" mass="76856" checksum="303CCF51CDD93E13" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5C4</accession>
    <name>Q1D5C4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4 6">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3969</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553979.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3969"/>
    <dbReference type="EnsemblBacteria" id="ABF86558">
        <property type="protein sequence ID" value="ABF86558"/>
        <property type="gene ID" value="MXAN_3969"/>
    </dbReference>
    <dbReference type="GeneID" id="41361301"/>
    <dbReference type="KEGG" id="mxa:MXAN_3969"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_2_7"/>
    <dbReference type="OMA" id="LPWEMKW"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="8">
        <location>
            <begin position="80"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="28846" checksum="2A1C409456BC4B6E" modified="2006-07-11" version="1">MFEALMNALLSIWTWIEIGLVALVGFCVQLSLAILTWAFDHKRHVTGRCFRLIGVTAAKLTPFWRFGVHGQVPDKVAPNTVVVSNHESNADPFLISHLPWEMKWLGKASLFKIPVVGWSMWMAGDVPVHRGDRDSATGAMAKCRQWLAKGMPVMIFPEGTRSKTDDLLPFKDGAFRLAIEAQADVLPLAVSGTRRALPKHSWRFATSRGLVTVGTPISTKGMTLADVETLKNLAREQILSLRASLMPLTRTEPAVPPGPASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5F4</accession>
    <name>Q1D5F4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553949.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3939"/>
    <dbReference type="EnsemblBacteria" id="ABF92581">
        <property type="protein sequence ID" value="ABF92581"/>
        <property type="gene ID" value="MXAN_3939"/>
    </dbReference>
    <dbReference type="GeneID" id="41361271"/>
    <dbReference type="KEGG" id="mxa:MXAN_3939"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_7"/>
    <dbReference type="OMA" id="MHEKTFH"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="247" mass="27757" checksum="616BF22AD2652728" modified="2006-07-11" version="1">MAPVVTLHEVEEGVAQITLVDRENKNMFSEQLVRELITVFGKVNGNERYRAVVLTGYDTYFALGGTKAGLLSICDGIGSFNVTNFYSLALECDIPVISAMQGHGVGGGFAMGLFADFVVLSRESVYTTNFMRYGFTPGMGATYIVPKRLGYSLGHELLLNARNYRGADLEKRGVPFPVLPRKEVLPHAYEIARDLAAKPRLSLVTLKRHLVRDIRRELPDVIERELEMHGITFHHDDVRRRIEQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5I8</accession>
    <name>Q1D5I8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553915.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3905"/>
    <dbReference type="TCDB" id="1.B.17.2.7">
        <property type="family name" value="the outer membrane factor (omf) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90429">
        <property type="protein sequence ID" value="ABF90429"/>
        <property type="gene ID" value="MXAN_3905"/>
    </dbReference>
    <dbReference type="GeneID" id="41361237"/>
    <dbReference type="KEGG" id="mxa:MXAN_3905"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_6_7"/>
    <dbReference type="OMA" id="RARAFFF"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187902" evidence="4">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="469" mass="49877" checksum="35D953AAE2C42364" modified="2006-07-11" version="1">MHRPRHAITVPLCAWLALTASSASGQQPATEGGAPAASESTKGAPASPPPAESLSTEGGPLTLEQAVQLAAKRNEVALAAEQQSEAARARLARARAFFFPELTGTGTYTRRLNEVTREVGGQTVVIQRNNAFNANFVASLPLFDARGIFLYRAARRDGDAAELEAVEARRQIGFEAANAFLATLAQEQVYRAAEQRLAFARQSLQDASARAKAGLASSNDVTRAELEAASAEVQMSNARNAAQTTRLELGFLLVSSVKGTLASPDVLLSDASRPLQAHASLADGALDRRPDILAARLRVDALEESAKEPLARLLPTLGASATYRLTNEAGLAGRTGDGFLGVNLIWNFFDGGERYAERRERVALARAAELQVQATTRRVDVDIEQARVALENAQAALAQSDLAVRTARQNAEEQGILYRQGLSTALTVADASLRQFEAEVAYAQSRFALGVALLGLRAAVGLDPLGKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Q5</accession>
    <name>Q1D5Q5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General secretory system II protein E, N-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553848.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3836"/>
    <dbReference type="EnsemblBacteria" id="ABF91355">
        <property type="protein sequence ID" value="ABF91355"/>
        <property type="gene ID" value="MXAN_3836"/>
    </dbReference>
    <dbReference type="GeneID" id="41361169"/>
    <dbReference type="KEGG" id="mxa:MXAN_3836"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078494_0_0_7"/>
    <dbReference type="OMA" id="ERYTVFP"/>
    <dbReference type="OrthoDB" id="1339098at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="2">
        <location>
            <begin position="105"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="308" mass="33232" checksum="6F169D885B6FFAFD" modified="2006-07-11" version="1">MHSPKPAAVRETAVSVASCRDCSTPFPSLTLLPGLLGVGWSAVVPDWLLCFTAVKQPPVTPSVSLPGRKRRLGEILMDAGLLSETQLRSALAEQRKWGGKLGLTLVQMGYVDESSMVHALSRQLAIPTVDLEQHAASAVVLQALRADIAERYTVFPIAADPATKTLTVATADPTNVEAFQELAFHCGQRLQVVVSSASSIERAIRRHYHGEVTSTTATPLSFGMDEPTFELAPPAESAPVSMAVRAASATLAQPGRETELTQRVEELTQQVAGLERMVAQQARSLRAMLELLETRGLVTRDDYLAKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U2</accession>
    <name>Q1D5U2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crt</name>
        <name evidence="3" type="ORF">MXAN_3799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553811.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3799"/>
    <dbReference type="EnsemblBacteria" id="ABF89228">
        <property type="protein sequence ID" value="ABF89228"/>
        <property type="gene ID" value="MXAN_3799"/>
    </dbReference>
    <dbReference type="GeneID" id="41361130"/>
    <dbReference type="KEGG" id="mxa:MXAN_3799"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="WERFEND"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="27168" checksum="5D3A5E82BDBA6D9B" modified="2006-07-11" version="1">MAYENIRLEQEGAIATLFIDRPKALNALNTKTLQELESALKSLPADVRVLIVTGGGEKAFVAGADIAEMAALTDAQAQEFGALGHRVMAALEALPIPTIAAVNGFALGGGSELALACDFIYASEKAKLGLPEVGLGVIPGFGGTQRLTRVVGRARAKELIFTGDRIDAAKAKEIGMVLEVLPADGLLAHCRAVAEKIVKNSPLAISKAKQVIEAGADQDLRAANDIERKAFGDLFGSEDQREGMKAFLEKRPATFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5U9</accession>
    <name>Q1D5U9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain G-beta repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553805.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3792"/>
    <dbReference type="EnsemblBacteria" id="ABF87934">
        <property type="protein sequence ID" value="ABF87934"/>
        <property type="gene ID" value="MXAN_3792"/>
    </dbReference>
    <dbReference type="GeneID" id="41361124"/>
    <dbReference type="KEGG" id="mxa:MXAN_3792"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_344133_0_0_7"/>
    <dbReference type="OMA" id="CRAVDTH"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="ANAPC4_WD40" evidence="2">
        <location>
            <begin position="511"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="799" mass="85512" checksum="7ECF224E80F119AE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V5</accession>
    <name>Q1D5V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3786"/>
    <dbReference type="EnsemblBacteria" id="ABF86010">
        <property type="protein sequence ID" value="ABF86010"/>
        <property type="gene ID" value="MXAN_3786"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3786"/>
    <dbReference type="eggNOG" id="COG3552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042261_2_0_7"/>
    <dbReference type="OMA" id="EPRHLWG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="493" mass="55726" checksum="476D34ED87F7F551" modified="2006-07-11" version="1">MYQGGRRPLASWLCIPDCARAIPGHDGCVDARIVEFAEVLRQNGVRVSTSEVQDALRATSEVGLKDRNLFRSVLRTTLVKRELDVDTFNRAFEFYFSGAARTFEDIDKSLAQQLEEEGYLEGDLLKMVLIQMHQLLPEMSPLAQAVLMGDRARLAQIFRMASLQLDLSRMESPLQAGFFSRRMLAAAGADKARNDMKSLEDELRARGLTPEGVEIVSRHVAAAMRKIEDAARQEVKRQAEARIRRRTDSAADKPLHLLTQAEVDQMESAVRTLAEKLRSRLIRKQRSHRKGALNVRRTLRRNLPWGGVPMVPQFRSRRPERPELVVLCDVSDSVRQASRMMLLFMHTMQSLFVRVRSFVFVSDVGEVTQYFKDLEVDAAIDMATAGKTVSLSANSNYGRALADFTRDHLGSITRRTTVMVIGDGRNNYNANNAWALKDLRRKAKRLLWICPEERGNWGIGDSEMLTYEKHCHQAVVVTSVSDLARIADQLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Z1</accession>
    <name>Q1D5Z1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553763.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3750"/>
    <dbReference type="EnsemblBacteria" id="ABF89514">
        <property type="protein sequence ID" value="ABF89514"/>
        <property type="gene ID" value="MXAN_3750"/>
    </dbReference>
    <dbReference type="GeneID" id="41361083"/>
    <dbReference type="KEGG" id="mxa:MXAN_3750"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073542_0_0_7"/>
    <dbReference type="OMA" id="RFHYATD"/>
    <dbReference type="OrthoDB" id="1742143at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="97"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="302" mass="33085" checksum="376C60C1D5497EF6" modified="2006-07-11" version="1">MRVQLTTVDLIIVVSCALASLLLLGPGRWAPDALRCAGLFAVVGVGPLVLRTLAASFPGHRWIHVLADWWLLPTAVMTHGWLSPVVDTVNPLLKDAQLVAADQRLFGMQAAVVLSRVVPAWLNDILLVCYYGHFIWALVMGLVLYRRPGGAEYDEYLTALGLLFFLNYAAYALVPAVGPRYFLVDAFDGPLQGTLAPLLDSLMRKPLFARDCFPSGHTGATMLVLYYAWRFSRRVFWVMLLPGLGLIAATLVGRFHYATDLLCAVPMVMVVTGLALGVSRAARQREVAKDARSVPVDAIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D630</accession>
    <name>Q1D630_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553724.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3707"/>
    <dbReference type="EnsemblBacteria" id="ABF91203">
        <property type="protein sequence ID" value="ABF91203"/>
        <property type="gene ID" value="MXAN_3707"/>
    </dbReference>
    <dbReference type="GeneID" id="41361040"/>
    <dbReference type="KEGG" id="mxa:MXAN_3707"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093128_0_0_7"/>
    <dbReference type="OMA" id="SFDVVYF"/>
    <dbReference type="OrthoDB" id="1696461at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="PTHR36112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="287" mass="31344" checksum="8D9774AECED5E81D" modified="2006-07-11" version="1">MAWRGASWMAESVAPSLRAWWMRGRRVTLVPLAVTTSTKVDAALVREARAVAARWGVPFLPRRAKESVAPWLGTKAAALLVVGGDGVTLWDAEGSFGFHAGMAHLRRMRLRAGEPDAFVRVAELRAGDSVLDCTLGLAQDAMVASLAVGPSGRVVGLERSLALGAVAGEGLRRYALGEDSGLIEVVHADAREYLKTLPSRAFDVVFFDPMFAKPRKSQPAFDMLRRFAEHAPLTQETLEEARRVARRWVVVKGAKYTDDLRKLGLEDEPGSRFTDVIWGRVGPSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6B6</accession>
    <name>Q1D6B6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553638.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3620"/>
    <dbReference type="EnsemblBacteria" id="ABF88653">
        <property type="protein sequence ID" value="ABF88653"/>
        <property type="gene ID" value="MXAN_3620"/>
    </dbReference>
    <dbReference type="GeneID" id="41360958"/>
    <dbReference type="KEGG" id="mxa:MXAN_3620"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_4_7"/>
    <dbReference type="OMA" id="YCAANIF"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1507" mass="161339" checksum="BA7D6A3143A142D3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6F8</accession>
    <name>Q1D6F8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553601.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3575"/>
    <dbReference type="EnsemblBacteria" id="ABF89769">
        <property type="protein sequence ID" value="ABF89769"/>
        <property type="gene ID" value="MXAN_3575"/>
    </dbReference>
    <dbReference type="GeneID" id="41360921"/>
    <dbReference type="KEGG" id="mxa:MXAN_3575"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110049_0_0_7"/>
    <dbReference type="OMA" id="LWVDMLG"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="20278" checksum="822E3BE09E9329E6" modified="2006-07-11" version="1">MNFPANTRAGRPCLEHLRLTGCRAMQTARPFRILGVQQIAIGGADKAPLRKLWVDLLGLTPHGTYRSERENVDEDIVTAGAGPFKVEVDLMQPVDPEKKPRVHETPLNHVGLWVDDLPVAVQWLESQGLRFAPGGIRKGAAGFDICFIHPKGSEQFPFGGEGVLIELVQAPKEVIAAFESLSTAGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6H9</accession>
    <name>Y3551_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0102 protein MXAN_3551</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_3551</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553580.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D6H9"/>
    <dbReference type="SMR" id="Q1D6H9"/>
    <dbReference type="STRING" id="246197.MXAN_3551"/>
    <dbReference type="EnsemblBacteria" id="ABF92414">
        <property type="protein sequence ID" value="ABF92414"/>
        <property type="gene ID" value="MXAN_3551"/>
    </dbReference>
    <dbReference type="GeneID" id="41360896"/>
    <dbReference type="KEGG" id="mxa:MXAN_3551"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_3_7"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000057336" description="UPF0102 protein MXAN_3551">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <sequence length="126" mass="14417" checksum="46A8C4F450025E7D" modified="2006-07-11" version="1">MRRAAPAERREYGNAGEEAAVRFLEAQGWRVRDRNWTCRFGELDVVAERDDLVCFVEVRMRSTATWGDPSHSVSFAKQRRVVKAALRYLFAHDLRGRMFRFDVISVVGRGERATVDHIPGAFDAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6J7</accession>
    <name>Q1D6J7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-succinylbenzoate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">o-succinylbenzoyl-CoA synthetase</fullName>
            <shortName evidence="2">OSB-CoA synthetase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">menE</name>
        <name evidence="5" type="ORF">MXAN_3532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17009"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553562.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3532"/>
    <dbReference type="EnsemblBacteria" id="ABF92964">
        <property type="protein sequence ID" value="ABF92964"/>
        <property type="gene ID" value="MXAN_3532"/>
    </dbReference>
    <dbReference type="GeneID" id="41360876"/>
    <dbReference type="KEGG" id="mxa:MXAN_3532"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_7"/>
    <dbReference type="OMA" id="TMTTIQL"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008756">
        <property type="term" value="F:o-succinylbenzoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00731">
        <property type="entry name" value="MenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010192">
        <property type="entry name" value="MenE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01923">
        <property type="entry name" value="menE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="4">
        <location>
            <begin position="394"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="482" mass="51114" checksum="06896BA9BF495792" modified="2006-07-11" version="1">MSVLLCPIRVGARHHPQAEALTFAGRSWSYEALDAEVSRWVAALEAEGVGASDRVASLATNHVASVCLFWALGRLGAVLAPLNARLTSVELAPMVEDIQPRLRLALGALAERLPGARPLESFAEAVSTGASTCQPLEASSPRVVLFTSGTTGRPKGAVLTEGNFRASSRASAGNLGAHPAPRWLGTLPLFHVGGIAMLTRTAYEGGCLVLHERFDADAANRAIDGEGVSHASLVATTLERVLEARGDRRMPDSFAWALIGGGPVPVPLLARARAAGLRALQTYGLTEACSQVTTERPDTADGRTAGVPLLGVEVRIVGAGGEVLGAGAEGDIEVRAPTVMAGYWQRPEATQEAVRDGWLRTKDVGVLDGGGRLTVLSRRTDLIVRGGENIYPAEVEAVLVNHPAVQEASVVGFPDDRWGERPVAFVAPRQGQPHPGDEELAAWCRQSLAGFKTPARFVWVDALPRNAMGKVERTVLRRHALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6U7</accession>
    <name>Q1D6U7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553462.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3429"/>
    <dbReference type="EnsemblBacteria" id="ABF88191">
        <property type="protein sequence ID" value="ABF88191"/>
        <property type="gene ID" value="MXAN_3429"/>
    </dbReference>
    <dbReference type="GeneID" id="41360776"/>
    <dbReference type="KEGG" id="mxa:MXAN_3429"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_7"/>
    <dbReference type="OMA" id="CTFEFGI"/>
    <dbReference type="OrthoDB" id="1459004at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="226"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="344" mass="37501" checksum="EBA9BD617E8C2213" modified="2006-07-11" version="1">MAKRTTRSARVGICLYPGVWGSSASLAKDLIHIASVIAQARPGSGNIEARFLGAKPAEVTTAGGPLLRAEDAWDRVDVDVLVLPSLAIPFMEPARQPPGLSDWIAGQHRRGCLVLALTTGSWLLAETGLLDGHTATTHWACLERCRRQYPRVNWTSEQRLAVTGRLVTARDMSASATALCHAIGRVLSAPIAERTYQYSLIYEPGADALPLLHTIPLRDHGDAQVLMVQEWIETHYGEPVAAEGVARMVHMSPRNLRRRFLDATGKTLVDYLTEVRLARARALLLSSNEAVSQIAYRVGYEDASTFTALFKKRHGLTPSAYRKTSAGPAGLSPAYDGERRTAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D793</accession>
    <name>Q1D793_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553326.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3281"/>
    <dbReference type="EnsemblBacteria" id="ABF92873">
        <property type="protein sequence ID" value="ABF92873"/>
        <property type="gene ID" value="MXAN_3281"/>
    </dbReference>
    <dbReference type="GeneID" id="41360634"/>
    <dbReference type="KEGG" id="mxa:MXAN_3281"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075026_0_0_7"/>
    <dbReference type="OMA" id="VQCHIKP"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="30387" checksum="FCB1DC620E60AA84" modified="2006-07-11" version="1">MMKALLKARVPRPLREADLSRVEGVFTDVDGTLTTGHKLRSETVRALERLSSAGLRVVLVSGRPAGWGEAWARQLPVDGVIVENGGLFFLKGAHGRLRKVYAEAPAERVANRRRLQSEVARVLKQVPGARLSMDSAYTEVDLAVDYNEEARLGAAGADRIESLLVARGVTAVRSSIHINCWLGRFDKLRATRRFARTAWGERLDPRDGRYVYAGDSFNDAPMFAAFGLGVGVANVRAVLDRIEAPPAFITRAPEGRGFEELARAILARRGRGAAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7A1</accession>
    <name>Q1D7A1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase, M19 (Membrane dipeptidase) family</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3273"/>
    <dbReference type="EnsemblBacteria" id="ABF92779">
        <property type="protein sequence ID" value="ABF92779"/>
        <property type="gene ID" value="MXAN_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3273"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_7"/>
    <dbReference type="OMA" id="CIADGHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="354" mass="38877" checksum="47DA785EB149FF6F" modified="2006-07-11" version="1">MSIGTRVVLVSRTRVGRLARMGDVKEFHQRWCIADGHADSLMWNRDLCERSEEGHVDFPRLREAGVKLQCFTIVTRGFPFIGGFPVFAAWRGWPREARASEWTRALWQIEQMASFCARSGDAARITTTGAMLEDNLAQGRLSAVLGVEGGHAIEGQVARLSELHQRGVRFMGLTHLSNNDLGGSSFPMMGNRGLTPLGRDVMEEMARLGMSVDVAHASESTLKDLFTHPSVRFFCSHTGVRAAGGGWRNLSDESLRFIADRGGVVGIIFAPVYLGGDTVDDVVRHIEHAVDVMGEGGVGLGSDYDGMVPLPRGMKDVTGLPLLTEALLRRHPPSWVERVMGGNFRRFFQETLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7I8</accession>
    <name>Q1D7I8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553231.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3182"/>
    <dbReference type="EnsemblBacteria" id="ABF86711">
        <property type="protein sequence ID" value="ABF86711"/>
        <property type="gene ID" value="MXAN_3182"/>
    </dbReference>
    <dbReference type="GeneID" id="41360537"/>
    <dbReference type="KEGG" id="mxa:MXAN_3182"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_0_0_7"/>
    <dbReference type="OMA" id="NDYQSFR"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="596" mass="64961" checksum="FC7DA424AF0C12A7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7X3</accession>
    <name>GCSH_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvH</name>
        <name type="ordered locus">MXAN_3041</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="1">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553097.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D7X3"/>
    <dbReference type="SMR" id="Q1D7X3"/>
    <dbReference type="STRING" id="246197.MXAN_3041"/>
    <dbReference type="EnsemblBacteria" id="ABF90620">
        <property type="protein sequence ID" value="ABF90620"/>
        <property type="gene ID" value="MXAN_3041"/>
    </dbReference>
    <dbReference type="GeneID" id="41360403"/>
    <dbReference type="KEGG" id="mxa:MXAN_3041"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_7"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0450">Lipoyl</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000022198" description="Glycine cleavage system H protein">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01066"/>
        </source>
    </evidence>
    <sequence length="129" mass="13778" checksum="D60E18E4F3DAB55A" modified="2006-07-11" version="1">MADNIPGDLKYTREHEWARVQGTSVVVGVTQHAQESLGDVVYVELPKVGSTVTEGKQFGVIESTKAVSELYSPLTGKVVKVNDGLSDNPSTVNTDPYGAGWIVEIEPSDPKQVDGLMDAAAYTALLQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D842</accession>
    <name>Q1D842_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553028.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2972"/>
    <dbReference type="EnsemblBacteria" id="ABF91665">
        <property type="protein sequence ID" value="ABF91665"/>
        <property type="gene ID" value="MXAN_2972"/>
    </dbReference>
    <dbReference type="GeneID" id="41360335"/>
    <dbReference type="KEGG" id="mxa:MXAN_2972"/>
    <dbReference type="eggNOG" id="ENOG50316Y6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1775452_0_0_7"/>
    <dbReference type="OMA" id="QGQWLME"/>
    <dbReference type="OrthoDB" id="1828334at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187977" evidence="3">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="140" mass="14986" checksum="A8E4C05554D1AFFC" modified="2006-07-11" version="1">MGTTRSVMTALCISLLSAGGAAYCYTRADALQVQGQWLMERGTAQAEDYAARFDGAAADAQLKTFAERRAILEKAHGWQRGMLLGVLIAALATVSAYLLFLLKRLNDQLLDATGSGAHEGTDRESASPEPVQALMPSPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8H2</accession>
    <name>Q1D8H2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2840"/>
    <dbReference type="EnsemblBacteria" id="ABF91885">
        <property type="protein sequence ID" value="ABF91885"/>
        <property type="gene ID" value="MXAN_2840"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2840"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_1_0_7"/>
    <dbReference type="OMA" id="AMDWVEG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="473" mass="50920" checksum="484CC9C765F05458" modified="2006-07-11" version="1">MGLPFLNPARLPPGTRVGPWRLMDLRGRGTYGAVYRARHITGTHTVALKLALHARDERFAREAELLSRIHHPAVPRLRASGRWQPAKGPPHPYLAMDWVEGTPLYDWASEHRPTSRQVMALLARLARALEATHAAGGLHRDVKGHNVLVREADGQAFLMDFGSSHYVGAATQTSSPFPPGTPAYRSPEAWRFAAGNSAPPYAPGQADDVFALGVTAFRMITGRYPPSTHPDVAESRFWHTERAQAPSPRDTNGHCCPELSALVSQMLAPSLHARGSARELAEALDSAVARAGSESNVPLMVGGALHSRASAQWKERSVRHRAQRPRWPWVAIIGLGGPLVLSLGWRPRAGAAVEVAPMPTAMSVEATDGGTVAVGDSVFAAPASPIQAPVAWSTIALEMPPRPFPGQTRPDASGRCPRKLQVPINGGCWVKLAVDNLKDCDEDGYVHKGACYGPAFPPTRPATSSPAHCPTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9E4</accession>
    <name>Q1D9E4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">gspG</name>
        <name evidence="13" type="ORF">MXAN_2510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552581.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2510"/>
    <dbReference type="EnsemblBacteria" id="ABF89813">
        <property type="protein sequence ID" value="ABF89813"/>
        <property type="gene ID" value="MXAN_2510"/>
    </dbReference>
    <dbReference type="GeneID" id="41359888"/>
    <dbReference type="KEGG" id="mxa:MXAN_2510"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_2_1_7"/>
    <dbReference type="OMA" id="PIDPWGN"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="12">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF89813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="15208" checksum="8A14AD9C9221CE74" modified="2006-07-11" version="1">MRQSQKQQRKQRRNRGMTLIEIMVVITILGLIAAAVGVAVIPQLEAARRDRAALDIKNIQGAMKLYYTKKGKYPDTASGLQALVEAQALEQMPKDPWNNDYVYINEGGKPVIISYGADGASGGEGNDADISSADAATSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M2</accession>
    <name>Q1D9M2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH dtxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552506.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2431"/>
    <dbReference type="EnsemblBacteria" id="ABF86895">
        <property type="protein sequence ID" value="ABF86895"/>
        <property type="gene ID" value="MXAN_2431"/>
    </dbReference>
    <dbReference type="GeneID" id="41359815"/>
    <dbReference type="KEGG" id="mxa:MXAN_2431"/>
    <dbReference type="eggNOG" id="COG1510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120349_2_1_7"/>
    <dbReference type="OMA" id="TLAFFEF"/>
    <dbReference type="OrthoDB" id="1646730at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="165" mass="18142" checksum="B403D972F1E6D237" modified="2006-07-11" version="1">MVELEAAERRFIESMGLYFERRGGTRIGGRIYALLMLAGKPLSNKRIAMLLNVSAASVSTNLRACTDMGLVEPASVPGDRQHYYVIHSQGWEGKLRVAEESLSAFGRLCSEALAVPRLAGNRSLREASAFCDFYKAELTGIAERWRAANAPRPPRPVKTSKGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA12</accession>
    <name>Q1DA12_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_2290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prespore-cell-inducing factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552366.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2290"/>
    <dbReference type="EnsemblBacteria" id="ABF90593">
        <property type="protein sequence ID" value="ABF90593"/>
        <property type="gene ID" value="MXAN_2290"/>
    </dbReference>
    <dbReference type="GeneID" id="41359677"/>
    <dbReference type="KEGG" id="mxa:MXAN_2290"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_470024_0_0_7"/>
    <dbReference type="OMA" id="TSEARYW"/>
    <dbReference type="OrthoDB" id="250493at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011874">
        <property type="entry name" value="Fibro_Slime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011936">
        <property type="entry name" value="Myxo_disulph_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13948">
        <property type="entry name" value="DUF4215"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02148">
        <property type="entry name" value="Fibro_Slime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02232">
        <property type="entry name" value="myxo_disulf_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188049" evidence="6">
        <location>
            <begin position="27"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="371"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="583" mass="61988" checksum="DFC3A4EEDC874AF0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB34</accession>
    <name>Q1DB34_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551995.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1894"/>
    <dbReference type="EnsemblBacteria" id="ABF87849">
        <property type="protein sequence ID" value="ABF87849"/>
        <property type="gene ID" value="MXAN_1894"/>
    </dbReference>
    <dbReference type="GeneID" id="41359309"/>
    <dbReference type="KEGG" id="mxa:MXAN_1894"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_0_7"/>
    <dbReference type="OMA" id="MIPSVET"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="115" mass="12661" checksum="11455605B1D35514" modified="2006-07-11" version="1">MNQQLAAHLGSIARLAREQMSLTQVQVAERVGLASAVYSRIERGLMIPSVETLKKLCIELMVSPEDLMGLTESPSSGSPTRPDDDVTLRRLIFLARKLDASKLDALVRITTELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBE1</accession>
    <name>Q1DBE1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1784"/>
    <dbReference type="EnsemblBacteria" id="ABF87563">
        <property type="protein sequence ID" value="ABF87563"/>
        <property type="gene ID" value="MXAN_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1784"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100517_0_0_7"/>
    <dbReference type="OMA" id="PHVPHGW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="26466" checksum="E1F64801B9338B70" modified="2006-07-11" version="1">MVETEVTEIAPRLYRLSTYISGANLLYNQFLIDAEEPSLFHLGPRALFPLVSAAVRKVLPLERLRWLTFGHVEADECGAMNSWLAAAPHAQVAHGAMGCLVSVNDLADRPPRPLQDGEVMDLGGKRLRRIETPHVPHGWDAGLFLEEATGTLLCGDLFTAMGDAPALTAQDIVGPALATEDGGHATCLTPATGPTIRALAALRPRTLGLMHGPSYTGDCARALQDLAAAYDERLDADLARRRGTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG4</accession>
    <name>Q1DBG4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551868.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1759"/>
    <dbReference type="EnsemblBacteria" id="ABF86652">
        <property type="protein sequence ID" value="ABF86652"/>
        <property type="gene ID" value="MXAN_1759"/>
    </dbReference>
    <dbReference type="GeneID" id="41359188"/>
    <dbReference type="KEGG" id="mxa:MXAN_1759"/>
    <dbReference type="eggNOG" id="COG4335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088207_0_0_7"/>
    <dbReference type="OMA" id="SVGNWLN"/>
    <dbReference type="OrthoDB" id="1292527at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="258" mass="28494" checksum="8CB2264F94D6ADF5" modified="2006-07-11" version="1">MSPSLPRKGATRATDIPPDVLDALSHGEMQTATLAECMALDQARLLRAVFPELSPDALAAADAACKLGILKRMSAIGALLLEELGTAGIERSRTHAADMVRGWACFMVGARPELDLQARLATIRPLADDSHFGVREWAWMSVRRHLARELDIAIAELSAWTSSRSEYVRRFATEALRPRGVWSAHIAELQREPGRALPILSPLRADPSVYVQDSVANWLNDAAKTQPGWVRDLCDQWLRGDPADATRRICKRASRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBK2</accession>
    <name>Q1DBK2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551830.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86351">
        <property type="protein sequence ID" value="ABF86351"/>
        <property type="gene ID" value="MXAN_1720"/>
    </dbReference>
    <dbReference type="GeneID" id="41359158"/>
    <dbReference type="KEGG" id="mxa:MXAN_1720"/>
    <dbReference type="HOGENOM" id="CLU_1401178_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="197" mass="21500" checksum="A330F25DCDCDD849" modified="2006-07-11" version="1">MKAATRYLVLLSMLVVGCGDSSEGEGDEDGSGGGSDSALKCDTVSWCSTWDADGAEVTDAPPLNGGKLSDGLYRRESGSSYPFAMLIKGKSVLLIEADLRNDLGTWKVENNRLVMTITSRCSNTEKETSNESWTWEHAFAVKNGVLYTKDLTWERPVVAWRKVESLCEESASFKCMVSNCACEFKTNTSLLGQTSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR9</accession>
    <name>Q1DBR9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551763.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89633">
        <property type="protein sequence ID" value="ABF89633"/>
        <property type="gene ID" value="MXAN_1652"/>
    </dbReference>
    <dbReference type="GeneID" id="41359094"/>
    <dbReference type="KEGG" id="mxa:MXAN_1652"/>
    <dbReference type="eggNOG" id="COG5646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120974_1_0_7"/>
    <dbReference type="OMA" id="ITEDVKW"/>
    <dbReference type="OrthoDB" id="1278667at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="49"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="159" mass="18012" checksum="D355B5AD63BDDA38" modified="2006-07-11" version="1">MRAADFAHGPGYAASTSPLEMSWCWREATRVSNRSEEVERFMQELEHARKDEVESLRTAILAAHPGIAERIKWNAPSFCFKDDDRVTFKLKPKDCVQLIFHRGAKVKATQGFSFDDTSGLLQWAAPDRAIVTLRDLAEVKAKKKALCQVVVQWMEATSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCL2</accession>
    <name>GPDA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">MXAN_1354</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword id="KW-0520">NAD</keyword>
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    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
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        <location>
            <begin position="1"/>
            <end position="335"/>
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    </feature>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="12"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <begin position="255"/>
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        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="335" mass="35858" checksum="695E4B3F42A1DF95" modified="2006-07-11" version="1">MRGSVIGSGSFGTALANVLAVNCEEVRLWGRESSVVEAINTQHENPTYLKGIPISERVRATNDLQEALVGSELVVLATPSHATREVVAKAQAYLPRHVPIVTVSKGIENGTLLTMTELLEDCLPEEFHPYLAVLSGPSFAKELARRMPTVVTIASHWDKVALRCQKALQTETFRSYTSTDVVGVQYGGALKNVIAIAAGMADGLGMGHNARAAIITRGLAEITRLAVRKGANPLTLSGLSGMGDLVLTCTGELSRNRHVGMELGKGRKLPDILADMKEVAEGVKTARSAHELELKTGVELPICHQVYLIAHEGKSARTAVVDLMTRQPKSELAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCP3</accession>
    <name>Q1DCP3_MYXXD</name>
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        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="MXAN_1323"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_1323"/>
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    <dbReference type="HOGENOM" id="CLU_060016_2_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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    </dbReference>
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        <property type="entry name" value="EamA_dom"/>
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        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="286"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF92158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="29473" checksum="265E5E3DD2AE5166" modified="2006-07-11" version="1">MGRRRGAALETAALVLVLSSAFLHAAWNALLKRHPNPEVGVVSVMSVVILASGIWALGMRGPAFSSSEGLVWALWAGVCESVYLAGLARSLRQAPLGLAYTVSRGGAMLLVWPVSVLWLGEAVSSWTVSGVAMLCVGLAVMNLSRPSGAAGAGVAWAALSAVGIAGYHLSYKMALGTGAQPPALFATGLLVALPVLILERGRQQGWAAFRREALLAPGLVLTAGLISALSFGLLLTALAGGGAGVVLTLRNTSIAFALVLAALQGERLGRRQLSGAALVAVGALLLGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCT0</accession>
    <name>Q1DCT0_MYXXD</name>
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        <submittedName>
            <fullName evidence="10">ABC transporter, permease/ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">abcA</name>
        <name evidence="10" type="ORF">MXAN_1286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91461">
        <property type="protein sequence ID" value="ABF91461"/>
        <property type="gene ID" value="MXAN_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1286"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="129"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="455"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="488"/>
            <end position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="709" mass="77011" checksum="E0262EBBDB328947" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCV5</accession>
    <name>Q1DCV5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, classes I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551378.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1261"/>
    <dbReference type="EnsemblBacteria" id="ABF91003">
        <property type="protein sequence ID" value="ABF91003"/>
        <property type="gene ID" value="MXAN_1261"/>
    </dbReference>
    <dbReference type="GeneID" id="41358707"/>
    <dbReference type="KEGG" id="mxa:MXAN_1261"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_7"/>
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    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="66"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="41076" checksum="9B75617261255F1C" modified="2006-07-11" version="1">MSRFSARTDFARTPNPLALALERLRASGRPLLDLTESNPTRVGLPLPDAALLAPEDAFSYEPESLGLASARQALVADFAARGAQVSEAHLLLTSSTSEAYGWLFKLLCEPGDNVLVPAPCYPLFEHLARLEGVQTRSYALPRAHGFGLDAGEVASACDARTRAVLVVNPGNPTGHFLHDGELAALADVCAHRQLALVCDEVFSPFASAPAPGRVATVAGRALPMLTFALSGLSKSAGLPGLKLAWTHVGGPAALRDEALARLDWVGDTYLPVGTLVQRVLPALLAHAPRFQAAVLERVRGNRQRLLAARPRDANWDVVPAEGGWSAVVRIPRAPGEEATCLALLDAGVRVQPGYFYDFGGGAFLVLSLLPQPEDFAAAVEVLARTLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDI1</accession>
    <name>Q1DDI1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551152.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1031"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87276">
        <property type="protein sequence ID" value="ABF87276"/>
        <property type="gene ID" value="MXAN_1031"/>
    </dbReference>
    <dbReference type="GeneID" id="41358485"/>
    <dbReference type="KEGG" id="mxa:MXAN_1031"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OMA" id="PWKGQHI"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="43974" checksum="21631A5D99E57E56" modified="2006-07-11" version="1">MRILFLNPVGILGGAERALLDLMACLKQQDSALSLHLLAGTAGPLLDEARALGVDARLLPLPEHLSTLGDSALRGHGPLEALRFARRLAPTSGLLVDHGRALRRDVADISPDLVHSNGIKTHLLSAATAGLPLKRVWHIHDFLGERPLVRRALRLLSPLASAAIANSRAVGDDTRQVLFRVPVHVVYNGVDTTHFSPGPADGAQLDRLAGLPEAPEGTLRVGLVATYARWKGQDVFLEAAATLTRLYPALPVRFYLVGAPLYQTPGSQFSEDELRRLIASRGLAERVGLVPFQPHPASVYRALDVFVHASTRREPFGLTIAEALACGRPAIVSNASGAAEALTNGTDALLIPPGNVHALVQALRTLLEDAALRARLGTAARLTAAASFSRERYASEVLTLYRTLVRSSPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDL0</accession>
    <name>Q1DDL0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551123.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1002"/>
    <dbReference type="EnsemblBacteria" id="ABF86898">
        <property type="protein sequence ID" value="ABF86898"/>
        <property type="gene ID" value="MXAN_1002"/>
    </dbReference>
    <dbReference type="GeneID" id="41358457"/>
    <dbReference type="KEGG" id="mxa:MXAN_1002"/>
    <dbReference type="HOGENOM" id="CLU_1260322_0_0_7"/>
    <dbReference type="OMA" id="RFWGAPL"/>
    <dbReference type="OrthoDB" id="1184647at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="23974" checksum="B50419D79D34301B" modified="2006-07-11" version="1">MRRLVLTAALLALASGCTKDDTQPADGIIEPIANPHQPGDFTPLPDPEDQDGSVGRAPRRLTVAQLDAAIVGAVGQRWSELDSRATSMGRADYALVVSENIEPNLVFAKFLEDGARKVCISQASAEMRMTDASARTMGRLLPEKWDDLTKLTDAEVRAQLVYMSTRFWGSPLSGEELTKWASFFTQAASRVQTLSSSKRHETLAVVCIAMLTDPRFITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDW2</accession>
    <name>Q1DDW2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_0900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551021.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0900"/>
    <dbReference type="EnsemblBacteria" id="ABF88372">
        <property type="protein sequence ID" value="ABF88372"/>
        <property type="gene ID" value="MXAN_0900"/>
    </dbReference>
    <dbReference type="GeneID" id="41358359"/>
    <dbReference type="KEGG" id="mxa:MXAN_0900"/>
    <dbReference type="eggNOG" id="ENOG502ZKG5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1957209_0_0_7"/>
    <dbReference type="OMA" id="YAATSPW"/>
    <dbReference type="OrthoDB" id="1789893at2"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18916">
        <property type="entry name" value="Lycopene_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lycopene_cyc" evidence="10">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14411" checksum="A30BC750D72B7FC5" modified="2006-07-11" version="1">MTYARFLGLFVVVPILFLAWRYRRTFTARSLAPMGLLLIVVYAATSPWDNLAVKWGLWGFDPERIWGIKLGYLPLEEYLFFGLQTLLVGLWAQARLARALAPDAQASRPAAETGERREGALTAREVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDX0</accession>
    <name>Q1DDX0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0892"/>
    <dbReference type="EnsemblBacteria" id="ABF86008">
        <property type="protein sequence ID" value="ABF86008"/>
        <property type="gene ID" value="MXAN_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0892"/>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_2_7"/>
    <dbReference type="OMA" id="KSVDCRY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="31710" checksum="31582C59AA13A262" modified="2006-07-11" version="1">MAVTGATGFLGPGLVQGLLERGHQVHVLARNVEHALARLPAGVTGAPFTAGSSLPPEALADAEAVVHLAGEPVAQRWTHEGKHRIHDSRVLGTRALVAAMRGAGTVRRFVSASAIGYYGGTRGADPLTEESPPGDDFLARVCVDWEAEAMQARESSIPTAVVRMGVVLHPEGGALHKMLPPFRVGAGGPVGSGEQFVSWVHREDARDLLLFLLAHPQVEGMVNATAPTPVTNAFFAHTLGHVLGRPSLVRMPAFMLKAALGEMAKVVLEGQRVLPQRAHEAGFVFRYPELEGALRDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE04</accession>
    <name>Q1DE04_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein, Hsp70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550979.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0858"/>
    <dbReference type="EnsemblBacteria" id="ABF92071">
        <property type="protein sequence ID" value="ABF92071"/>
        <property type="gene ID" value="MXAN_0858"/>
    </dbReference>
    <dbReference type="GeneID" id="41358317"/>
    <dbReference type="KEGG" id="mxa:MXAN_0858"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033976_2_0_7"/>
    <dbReference type="OMA" id="HEYLEGY"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10231">
        <property type="entry name" value="YegD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042054">
        <property type="entry name" value="YegD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="418" mass="46078" checksum="EF8400EA12477D2E" modified="2006-07-11" version="1">MRACGLDFGTSNTAAALPDGTVLSLQPNTSEARLFRSVLFFPDDEQDIYAGAGAIQRYLEDNTGRFIQSVKSFLHSSSFRATQVKGRTYTIEELVAVLLRRVRDAAASAMGGAPEAVVLGRPAVFTPDPEADALAQQRLLRAAELAGFQHVQFLIEPIAAALAYEAQLTRDELVLVADFGAGTTDLTLMRLGPSRRGNPDRRQDVVGSTGVRIGGDRFDAEIMRHKLLPRFGAGSTYQVRGFSDKRLPIPQHIMAKLLTWHEMSFIRERSTQELLETMLNTSDRKAEIQALYDLVMDNLGYRLFRAIEAAKVRLSQEDTATVDFEEARITLHEPITREEFDTFSQPLLDELDACTAGLLEKHAEAKDIDAVFLTGGSSQIPAVRQLYMRRFGEGRVRTADAFTSVAEGLGRAAAHLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE96</accession>
    <name>Q1DE96_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550887.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0761"/>
    <dbReference type="EnsemblBacteria" id="ABF86491">
        <property type="protein sequence ID" value="ABF86491"/>
        <property type="gene ID" value="MXAN_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="41358230"/>
    <dbReference type="KEGG" id="mxa:MXAN_0761"/>
    <dbReference type="eggNOG" id="COG1946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084775_0_0_7"/>
    <dbReference type="OMA" id="LTWTIEF"/>
    <dbReference type="OrthoDB" id="1715623at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="270" mass="29267" checksum="BFEAD949591A3A87" modified="2006-07-11" version="1">MTAAFLAATTPEPLSPNRYGIRFTAPWYQGKGAYGGIVAGSTLRALEHTLAQAQQPGRPVRTLTVHFCAPAVEGEAEIQTRIERTGRLVTHATARIESAAGVLCVATATFGTSRGGATEYFDVKRPVVPPPEDVPVVPDDVPMPTFCSFFEYRFCVGSAPYSGADVAETGGWLRPREPMVLDAPLCVGLMDAYPPSVLSRVDGFHAAASVDFTVHFFHDLPRPGLREDAHFLRTGRSRQAAEGYSEDFQQLWTQEGELLAQCRQLVAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEB2</accession>
    <name>Q1DEB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0745"/>
    <dbReference type="EnsemblBacteria" id="ABF87654">
        <property type="protein sequence ID" value="ABF87654"/>
        <property type="gene ID" value="MXAN_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0745"/>
    <dbReference type="HOGENOM" id="CLU_1154899_0_0_7"/>
    <dbReference type="OMA" id="YTGQDRY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="239" mass="25830" checksum="94B938B4D5799772" modified="2006-07-11" version="1">MREERGRQAGERWVVFCFGTFAPSLRSHMAETSVETLKTAVQALYRVHAVEGPPGENGLRTVWHLCPDGAELMSLVDSEGRVRRQELTLLEDHYVWASGEGVRTGYLERGGGKPTAAAVVQTDPELVPQRLMRAALAMGTYTGQDRYLLHMQRVLALAREGLEMKGGLTRPSEPTLPAVEAPVVSTAQAAVFDVPPAAVAVVEDVTPPVVRRGEGVTMLLVLALGLLVGFGMLAFILMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEM7</accession>
    <name>Q1DEM7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550759.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0628"/>
    <dbReference type="EnsemblBacteria" id="ABF91835">
        <property type="protein sequence ID" value="ABF91835"/>
        <property type="gene ID" value="MXAN_0628"/>
    </dbReference>
    <dbReference type="GeneID" id="41358106"/>
    <dbReference type="KEGG" id="mxa:MXAN_0628"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110258_0_0_7"/>
    <dbReference type="OMA" id="CPRVHFK"/>
    <dbReference type="OrthoDB" id="1643730at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="210" mass="22796" checksum="6C021D96CF932247" modified="2006-07-11" version="1">MRPIEAELLSGSALYREVVLEKLLHARESVWMATANVKAMFVEHGGRFVPLVDVLDTLAARGVALRLLHAELPSRPFRAAFDRQARLVAGGLSLKVCPRVHFKAVVVDGAWAYLGSANLTGAGLGAKGDSARNFELGFVTEDFDVIDRVTALYEAVWSGAECKSCKLRAVCPDPILPAGKRAPTPRRPRADAPRLGKARRLQRGTKAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEP1</accession>
    <name>Q1DEP1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0614"/>
    <dbReference type="EnsemblBacteria" id="ABF88229">
        <property type="protein sequence ID" value="ABF88229"/>
        <property type="gene ID" value="MXAN_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0614"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="PEYSLLW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="71"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="494" mass="53375" checksum="4A236C2E22D4B4C4" modified="2006-07-11" version="1">MPPDRRCVPGVMRARAPPWCLLQGTMHCELCLTEHPYDVACGGEPWTQVYLSTGDAEAPPADLTGQTLGSYRLVRRLGAGGMGTVYLGEQTRIGARVAVKVLHPHLGRDESLRARFYAEARTVNVVGHPNIVHIFDINEAPGGIHYFVMEYLEGVPMSHLPRPMVPATLVSLLAQACDALDAAHRCGVVHRDLKPDNLFVVRHAGEPPSLRVLDFGVAKARRPHPGEDETAAGIVLGTPAYMAPEQSAGQPVDGRADIYALAVTAYYLSTGQLPFERGQMVELALGTGPVGAPPPHLLVPGVPPALSEVLLRALSRRCEDRYATALEFKEALLLAAAQPLADALSPQTPPPRSHTPVPSLAWLDTEDPATEPNALTPPLTWVARVRRRSGAGDVEVLCTELSRGGLFMCCADPFPRLFNRLEFTLLLAGELVECAGEVVRHVDAAQAQTWGMLSTGVGVQFINPSARLCELIRRVQPHRLTTPASTLMRAEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF96</accession>
    <name>Q1DF96_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0406"/>
    <dbReference type="EnsemblBacteria" id="ABF86322">
        <property type="protein sequence ID" value="ABF86322"/>
        <property type="gene ID" value="MXAN_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0406"/>
    <dbReference type="HOGENOM" id="CLU_166195_0_0_7"/>
    <dbReference type="OMA" id="LRVGGMW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="127" mass="14314" checksum="65236C848F4BF431" modified="2006-07-11" version="1">MSTQPTVACHAPVEVRRWRSALARRDSRAVDTRRVYPRFAIASLLGNVAFLASWGVVLMRPSGWQVVGPLLLLMFLVLRVGGMWLFASRHPEEERPRMRRTATLTTVLALIAVGIWVYTVLQGPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFC7</accession>
    <name>Q1DFC7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550510.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0372"/>
    <dbReference type="EnsemblBacteria" id="ABF91645">
        <property type="protein sequence ID" value="ABF91645"/>
        <property type="gene ID" value="MXAN_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="41357871"/>
    <dbReference type="KEGG" id="mxa:MXAN_0372"/>
    <dbReference type="HOGENOM" id="CLU_1969205_0_0_7"/>
    <dbReference type="OMA" id="CTSQEEH"/>
    <dbReference type="OrthoDB" id="1992561at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="128" mass="14245" checksum="84E06477F9E73A4E" modified="2006-07-11" version="1">MGIRRRWLGLSMVMGLSLGTGCMSPSQEAQERLAALEAEGEAMDAVLDSVEERLLGNQAMLQTWQELGRRHQQVTQLHCETSDPHMIAMMKHYKKQEDRARQLKRRGSGVASVDKAVLTSGKAPRGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFE2</accession>
    <name>Q1DFE2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0357"/>
    <dbReference type="EnsemblBacteria" id="ABF86778">
        <property type="protein sequence ID" value="ABF86778"/>
        <property type="gene ID" value="MXAN_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0357"/>
    <dbReference type="HOGENOM" id="CLU_1014996_0_0_7"/>
    <dbReference type="OMA" id="VEDREQP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188483" evidence="2">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="29387" checksum="90941BB4C1A9C021" modified="2006-07-11" version="1">MSLMRVWLMCVALATAPSVGLAETSKPAAPKGRPSAEAKAGKAPPKKAPAAGAKPAPAPAPGQDAGTPPARPSFRWDIPAVTAWVESPGLQVTDGVPMHLQLARTSWQMDPLIQHMVDRFRAAGLFISSSPEALNSPIAEPMLTALDTETLTAYTVIFQKNQDNTVTLILGTSDVSKYTPGGSIQLDWAPVMAGAEQVTRSNLEGSQMAMYAVKATSAEVREFYQVELTRAGFVEDREQPGVFQRGTEQLTIRTQPEGDMLMVGLYRKLGVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFG3</accession>
    <name>Q1DFG3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_0336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550474.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0336"/>
    <dbReference type="EnsemblBacteria" id="ABF87578">
        <property type="protein sequence ID" value="ABF87578"/>
        <property type="gene ID" value="MXAN_0336"/>
    </dbReference>
    <dbReference type="GeneID" id="41357834"/>
    <dbReference type="KEGG" id="mxa:MXAN_0336"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="HGRITIV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="464"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="698" mass="78200" checksum="F83657F912C17D4E" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFH7</accession>
    <name>Q1DFH7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550460.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0316"/>
    <dbReference type="EnsemblBacteria" id="ABF92724">
        <property type="protein sequence ID" value="ABF92724"/>
        <property type="gene ID" value="MXAN_0316"/>
    </dbReference>
    <dbReference type="GeneID" id="41357815"/>
    <dbReference type="KEGG" id="mxa:MXAN_0316"/>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036032_1_0_7"/>
    <dbReference type="OMA" id="TCERHAW"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007434">
        <property type="entry name" value="FemAB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04339">
        <property type="entry name" value="FemAB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="43742" checksum="AD76555F7B485C7E" modified="2006-07-11" version="1">MPADTPLRLRILEAVTDAPAEGWDALVGPDAPPFVRHAWLAAMEESGSATEETGWAPHHLTLWRGPKLVAAAPAYLKFHSMGEYIYDFGWADAAARLGVEYYPKLVVGGPLSPATVPRFLIAPGEDVPALRRALLAAAAGSAQEAGCSSVHVLYPTGDEADFLEAEGLARRITLQFHWKNPGYGSYDDYLARFDSKRRNQLKRERGAAATQGISLRTVRGEGLSQAHARRAYGFYTSTCERHAWGQIQLTPDFFARVFRTMPGSVELVEAVRGQQVIAGAFNLATPERLYGRYWGAFEEHPFLHFHVCLYHSVEDCIRTGRKVFEPGAGGEHKVSRGFEPTAVHSAHLIFDKTLDGAVRGFLRREHARLAPAVEEAERICGLKPWPLAASPGTQGATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFK3</accession>
    <name>Q1DFK3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550434.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0290"/>
    <dbReference type="EnsemblBacteria" id="ABF90040">
        <property type="protein sequence ID" value="ABF90040"/>
        <property type="gene ID" value="MXAN_0290"/>
    </dbReference>
    <dbReference type="GeneID" id="41357789"/>
    <dbReference type="KEGG" id="mxa:MXAN_0290"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_3_0_7"/>
    <dbReference type="OMA" id="IVVFTCN"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188485" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="193" mass="20712" checksum="81FEF43FD8F79DF9" modified="2006-07-11" version="1">MKQVFTALALGTLLIGAPALADAEVGKPAPTFTLKDESGKEHTLAQYKGKVVVLEWTNPECPFVQRHYKNDTMVTTLKGFDAKKVVWLAVDSTAHNTPEKSAAWKKDEGFPYPVLQDASGTVGKSYGAKTTPHMYVIDETGVVRYAGAIDDDPRGKNAKPANHVKTAVDAVVGGQQVPASTTTPYGCSVKYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFL9</accession>
    <name>Q1DFL9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TonB system transport protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550418.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0273"/>
    <dbReference type="EnsemblBacteria" id="ABF89022">
        <property type="protein sequence ID" value="ABF89022"/>
        <property type="gene ID" value="MXAN_0273"/>
    </dbReference>
    <dbReference type="GeneID" id="41357773"/>
    <dbReference type="KEGG" id="mxa:MXAN_0273"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_7"/>
    <dbReference type="OMA" id="WMTVPAK"/>
    <dbReference type="OrthoDB" id="1746415at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="141" mass="15230" checksum="A32BA66F14383F5C" modified="2006-07-11" version="1">MAFDLGGGKGSIRPAMNVTPLVDVVLVLLIIFMVVTPLMTKQMWMTVPAKGDDQEAPPPPPDAKPPVVLTVDKSGVLRINREEVPRDQVVARLQRMLNARPDKIVFFDASDDVPYGAAMDVLDLARGGDITVGVLPDKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG03</accession>
    <name>Q1DG03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550284.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0137"/>
    <dbReference type="EnsemblBacteria" id="ABF85964">
        <property type="protein sequence ID" value="ABF85964"/>
        <property type="gene ID" value="MXAN_0137"/>
    </dbReference>
    <dbReference type="GeneID" id="41357640"/>
    <dbReference type="KEGG" id="mxa:MXAN_0137"/>
    <dbReference type="HOGENOM" id="CLU_955894_0_0_7"/>
    <dbReference type="OMA" id="ELHEATF"/>
    <dbReference type="OrthoDB" id="1527043at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="291" mass="31319" checksum="BC76AE0B9C3C3E3C" modified="2006-07-11" version="1">MLAMIQVDELGEKTTFAEVARRFAGASWLASFLETEQLNDPETNGIVVPRIVNTGLRLDDTLKSGPGPWAVIIDGDLETSGDLVCTTDDYLTSTLIVTGNVRARNVRFAASARVGIEGDLVVGRGLGIVSGTWGDGGAVLWARSCEAALVLLDGNTSIDADRCRRTLVCGSTGWGEFTPDIHDHATFEEMFEPAAFDERGDLDFGRAMALANEGRSALRPEVENRLRGSKGLATREALAWLTSDPHCRELMALGDDRSMAVLAEQLAQRGHTVSIESLTRSVRAMLGARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG97</accession>
    <name>Q1DG97_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550192.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0043"/>
    <dbReference type="EnsemblBacteria" id="ABF86677">
        <property type="protein sequence ID" value="ABF86677"/>
        <property type="gene ID" value="MXAN_0043"/>
    </dbReference>
    <dbReference type="GeneID" id="41357552"/>
    <dbReference type="KEGG" id="mxa:MXAN_0043"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643769_0_0_7"/>
    <dbReference type="OMA" id="AWEHARG"/>
    <dbReference type="OrthoDB" id="1684783at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011959">
        <property type="entry name" value="CHP02270"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02270">
        <property type="entry name" value="TIGR02270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="446" mass="48661" checksum="E54BDDB0DFB5377C" modified="2006-07-11" version="1">MRPLSPPRPTVRWELLERHLEEAEFLWTQWEHGLWSPELTLSSLAEGDEGRLRAHLDALVLGGSAAATRLLLPALTSEDPARVASAAWALLSAEDADWREPVFQQLEQGSEETHPGLLRALELLDRPDLHALLLKKLPTLQPTLQAGALRVARVRHLDTSAALEKLDWEADPALHAEALRALPFAPRMQTGDARLSRALSHAHPTVSTAALETGLLLGSREAWEHARGSASRGGLLALAVAGESKDLTGLLARLKDGSAPAEVIWAVGFSGRLLAAEALLPLLRDEAQGPLAAASFAAITGLPMVPPFLVEAPADEEEDAEEAEPEAEDLQAWLPSPRVLPGEVDAQAVEAWWTRRRGGFTEGARFLRGIPLTVEVLVRALETEPMRRRPSLAWEAALRGGGTPQMESRQWTRVQREQALPLRGQRPEWLARAGSWPQGRRGDTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVJ1</accession>
    <name>Q1CVJ1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87873">
        <property type="protein sequence ID" value="ABF87873"/>
        <property type="gene ID" value="MXAN_7480"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7480"/>
    <dbReference type="HOGENOM" id="CLU_1174419_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="236" mass="25742" checksum="B00093D18E918960" modified="2006-07-11" version="1">MSKSSWELQRGAPGWSPPNARPTLPRNLHQHAHWTACVVGAAPHTGAPHGARASRWLHLPPVRAPIWGLHASRSASGAPHGAGTGWWMSAGPFATPLHATRWSTHHSMNHERITSLNAEPSANSPALRACPPSIHPAFHVEQALSNPRMSSRAIHFTEVHASARASFPPSVRNSRQAERMRESMRCAGAPPPSPSPRSAHAERRPPTTAKQHLMRRFFVPRGTRVRELAGTPPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVN0</accession>
    <name>Q1CVN0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7438"/>
    <dbReference type="TCDB" id="2.A.6.1.11">
        <property type="family name" value="the resistance-nodulation-cell division (rnd) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88073">
        <property type="protein sequence ID" value="ABF88073"/>
        <property type="gene ID" value="MXAN_7438"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7438"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_3_7"/>
    <dbReference type="OMA" id="VWNEDKT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188095" evidence="2">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="61"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="367" mass="37933" checksum="0179210568A9873D" modified="2006-07-11" version="1">MNRTLLLGLWAFSAACSGAGTPSASAERAAPAPLKEGVVQLAEASRAFITVTPVKADASSAALQAPARVAFRDGALSRLVAPLAGRVVSVHVRTGDTVKPGDALVTLDCPEAAASRTAVATATAALREAQSAFEREARMFEQGVTTERERLSAETRLAEARAELARAQASVGFVGTGSGTTVVLRAPMAGTVLGRSAAEGIAVQPGGDVLVEVGDPSALWVMADVFERDLPLVREGARVRVTMPSVHAPLEGKVDSVGAVVASGSRTAPVRITLDTQEQSLRPGMFGRVRIDSPDASLTLPVEAVLLRNGKDSVVYVQQDAGTFERRPVVVAQPVEGRVQVIAGLSPGDPVVTRGALLLDGAADQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVT6</accession>
    <name>Q1CVT6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557292.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7380"/>
    <dbReference type="EnsemblBacteria" id="ABF91405">
        <property type="protein sequence ID" value="ABF91405"/>
        <property type="gene ID" value="MXAN_7380"/>
    </dbReference>
    <dbReference type="GeneID" id="41364539"/>
    <dbReference type="KEGG" id="mxa:MXAN_7380"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713541_0_0_7"/>
    <dbReference type="OMA" id="NGRDETH"/>
    <dbReference type="OrthoDB" id="864659at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="306"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="380" mass="42610" checksum="D432258C2D2CDFF3" modified="2006-07-11" version="1">MAHRSMDNGRDETHREADVAPPGSRERAESDLTGWNPARDEEASIRQGRYHRAATMRMAQPRTQVDDEPGEDVYGAPPEDSGPYGRDDRDSHYATGRGPRHDTGEQDVELSRQRADYRPWDRSGYGGEPSRPQPPQGESYRDVRFHGRERGAHGEERHGDARPRYRMDRSASLGPGRDEASTHRWAGTGAPSSTGARRDGASTPIYTAVAGRSETSTSRRDDRARNGRWRHEALLAREVMTRNVRTARPESPLRDIARIMKDESCGVVPIVDERDRLVGIVTDRDLVVRAFTGGRSPEQLRASDVMTDDVEAVTPDDTLHDVIGLMGRRQLRRIPVVERDDGIVGIISLGDIALRADHDEELQQALERISSKRSFWSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVY1</accession>
    <name>Q1CVY1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glpD</name>
        <name evidence="10" type="ORF">MXAN_7329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557248.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7329"/>
    <dbReference type="EnsemblBacteria" id="ABF89798">
        <property type="protein sequence ID" value="ABF89798"/>
        <property type="gene ID" value="MXAN_7329"/>
    </dbReference>
    <dbReference type="GeneID" id="41364492"/>
    <dbReference type="KEGG" id="mxa:MXAN_7329"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_5_1_7"/>
    <dbReference type="OMA" id="FAYSDCW"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="36"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="421"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="565" mass="60821" checksum="5E78324F3785B3AF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWD2</accession>
    <name>Q1CWD2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557097.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7178"/>
    <dbReference type="EnsemblBacteria" id="ABF92762">
        <property type="protein sequence ID" value="ABF92762"/>
        <property type="gene ID" value="MXAN_7178"/>
    </dbReference>
    <dbReference type="GeneID" id="41364351"/>
    <dbReference type="KEGG" id="mxa:MXAN_7178"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="VMNGAQF"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13124" checksum="DC039D67F6D875B7" modified="2006-07-11" version="1">MSAASPTVLVVDDDADIREAVQDILSFEGYAVAQAANGQEALELLTGPHAVRPCLILLDLMMPVMDGEEFVGRIQQEQRLAELPIILVTASGRAHLPGVRAILKKPFDMDVLLSTVGEHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWP1</accession>
    <name>Q1CWP1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556988.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7069"/>
    <dbReference type="EnsemblBacteria" id="ABF90972">
        <property type="protein sequence ID" value="ABF90972"/>
        <property type="gene ID" value="MXAN_7069"/>
    </dbReference>
    <dbReference type="GeneID" id="41364244"/>
    <dbReference type="KEGG" id="mxa:MXAN_7069"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_2_2_7"/>
    <dbReference type="OMA" id="DMDAMGH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="16837" checksum="04FE7E9C278BB021" modified="2006-07-11" version="1">MPDSPLKDFPVVVSFPLHWGEMDAFGHANNTRTFTWFETARIHYFARIGLTGPSGAGDERTNRDGVGPILKATNAEYLRPILFPTRLVAGCRATRIGTSSFTLEHAVAGEDDGVLYTRGSCVIVTLRYATHEKVPVPAELRAAIEALEGRSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWS4</accession>
    <name>Q1CWS4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7036"/>
    <dbReference type="EnsemblBacteria" id="ABF92947">
        <property type="protein sequence ID" value="ABF92947"/>
        <property type="gene ID" value="MXAN_7036"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7036"/>
    <dbReference type="eggNOG" id="COG0435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3273146_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="41" mass="4631" checksum="5F72A5E5B9A97DC7" modified="2006-07-11" version="1">MVDPRMGDDGWTFQGEPGSDPEPFCGFEFLREPHDRTLGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWU3</accession>
    <name>Q1CWU3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csd3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csd3</name>
        <name evidence="1" type="ORF">MXAN_7017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556936.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7017"/>
    <dbReference type="EnsemblBacteria" id="ABF87628">
        <property type="protein sequence ID" value="ABF87628"/>
        <property type="gene ID" value="MXAN_7017"/>
    </dbReference>
    <dbReference type="GeneID" id="41364193"/>
    <dbReference type="KEGG" id="mxa:MXAN_7017"/>
    <dbReference type="eggNOG" id="COG3649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071770_2_0_7"/>
    <dbReference type="OMA" id="YDFVLLF"/>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013418">
        <property type="entry name" value="CRISPR-assoc_prot_Csd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02589">
        <property type="entry name" value="cas_Csd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="33479" checksum="A153547E52F78399" modified="2006-07-11" version="1">MTDLKQRHDFVLFFDVLDGNPNGDPDAGNLPRIDAETGHGLVTDVSLKRKVRNFVLLTQEGKPGLDIFVKEKAILNNRIADGYKSLGIDLNEKPARAEDGKKRNDKGRAQGSEVEKGRAWMCKTFFDVRTFGAVMSTGPNAGQVRGPVQLTFARSVDPIVSQEHSITRMAVATEDEAEKQGGDNRTMGRKNTVPYGLYRAHGFVSPHLAKQTGFGTADLELLFQSFTHMFELDRSAARGLMSMRKVVVFKHGSELGNAPAHALFDRVLAVRAQPEKPARSFSDYEVRVDKAGLPQGIEVLELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWY9</accession>
    <name>Q1CWY9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6969"/>
    <dbReference type="EnsemblBacteria" id="ABF89787">
        <property type="protein sequence ID" value="ABF89787"/>
        <property type="gene ID" value="MXAN_6969"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6969"/>
    <dbReference type="HOGENOM" id="CLU_1501939_0_0_7"/>
    <dbReference type="OMA" id="DKPMAIE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187999" evidence="2">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="192" mass="19990" checksum="94227D06DCAD0065" modified="2006-07-11" version="1">MLPAVGPTELNPGRRMMKKLIAAVALCVGSAAFAQQQPSQTQVPRPGTEKSTGVDATEVGPAIGKAAKDVTGIQTEDEGTFKMDKAMSLQGTLKEATADGVSLSRPGLPDADLDVRDKTVLMLDGKKVAKTDEIPEGASVRAKFQLEGDEVVALELRATSPKGAKKKQPGTGGAGTQPHESVDKELDGTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX03</accession>
    <name>Q1CX03_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">todK</name>
        <name evidence="8" type="ORF">MXAN_6955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556876.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1CX03"/>
    <dbReference type="STRING" id="246197.MXAN_6955"/>
    <dbReference type="EnsemblBacteria" id="ABF86072">
        <property type="protein sequence ID" value="ABF86072"/>
        <property type="gene ID" value="MXAN_6955"/>
    </dbReference>
    <dbReference type="GeneID" id="41364133"/>
    <dbReference type="KEGG" id="mxa:MXAN_6955"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="MGIVTHD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="272"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="55783" checksum="0AA2B8BB10B9C677" modified="2006-07-11" version="1">MPPTPAKKRQRPLAEPSAEAPSPELLQTLLEALPDAFFLLDARWCLAYVNPDMARLLGGAARLQDDVRRVCPELLELSRHLHFEQPVSEQPSVRYEHAWPEAETCLDVRVRPVEGGLLVHCRDITEERKGREALRRNGEVFRAILEGTTDAVYTKDLDGRFTMMNAAGAKAVGYRAEDVVGRTDLELFDPAVARTNAANDREVFAFGRTVTYEDAQPGVDGPRVWLSTKGVLRDAEGKVFGLFGISRDITQRKWAEEETRRHSEFQEQLMGIVTHDIRSPLGAIMNWSRVLAAGGTDEDAQRTSQRIATAAVRIERLTRLLLDFTRTRLMGGVAIEPRPVDLKDLVAKVAHEFGVAFPQRTVEVDPKGNTQGVWDPDRLAQVTSNLVENALKYSPPETPVRLTARGLRTRVVLEVHNAGRPIPDNLLPHLFEPFRGGPQSSRTLKMSYGLGLFIVREIVQAHGGTIEVRSDEAEGTTFTVTLPRRSMPARPPQPPTGSPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX73</accession>
    <name>Q1CX73_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4105 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556808.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6885"/>
    <dbReference type="EnsemblBacteria" id="ABF86967">
        <property type="protein sequence ID" value="ABF86967"/>
        <property type="gene ID" value="MXAN_6885"/>
    </dbReference>
    <dbReference type="GeneID" id="41364073"/>
    <dbReference type="KEGG" id="mxa:MXAN_6885"/>
    <dbReference type="eggNOG" id="ENOG50319QF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315175_0_0_7"/>
    <dbReference type="OMA" id="YFFTDNC"/>
    <dbReference type="OrthoDB" id="61104at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025178">
        <property type="entry name" value="DUF4105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13387">
        <property type="entry name" value="DUF4105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188004" description="DUF4105 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4105" evidence="2">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="928" mass="102127" checksum="B6C49079C1CFCDE5" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXB8</accession>
    <name>Q1CXB8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6838"/>
    <dbReference type="EnsemblBacteria" id="ABF91829">
        <property type="protein sequence ID" value="ABF91829"/>
        <property type="gene ID" value="MXAN_6838"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6838"/>
    <dbReference type="HOGENOM" id="CLU_1293210_0_0_7"/>
    <dbReference type="OMA" id="GEHACWH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187876" evidence="1">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="23150" checksum="3E6AA24BEA3AEC54" modified="2006-07-11" version="1">MKHLMRPTLRVLFLTACAAAAVACGGDDDPAPIEPGDSCEPNGHIHREPSGDWCHCNKGYVAADDGLACVPDPNHVPGDGFDFGDDGEHACWHVTNGPFVTVNATTARHPRVDDFHTYYTVKLLPENSQYVGTFSYKAFATGNFVVYLSSPDVPVTLTETAISTTVPQAGAQATGGFCDGLKHMVGYELTDRVQYTLQLGPTSLPELNMVIEHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXG9</accession>
    <name>Q1CXG9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Late embryogenesis abundant protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556712.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91591">
        <property type="protein sequence ID" value="ABF91591"/>
        <property type="gene ID" value="MXAN_6787"/>
    </dbReference>
    <dbReference type="GeneID" id="41363977"/>
    <dbReference type="KEGG" id="mxa:MXAN_6787"/>
    <dbReference type="eggNOG" id="ENOG5032YSX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478831_0_0_7"/>
    <dbReference type="OMA" id="DTHEAKL"/>
    <dbReference type="OrthoDB" id="477190at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="647" mass="64193" checksum="AF91B5CB0E36E18A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY61</accession>
    <name>Q1CY61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89118">
        <property type="protein sequence ID" value="ABF89118"/>
        <property type="gene ID" value="MXAN_6540"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6540"/>
    <dbReference type="HOGENOM" id="CLU_2437744_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="90" mass="9710" checksum="42204874B9E2B2A9" modified="2006-07-11" version="1">MPRGGGHRHALTARTRASRGPRFRAGARRQPATNMARCRAGRMRAVAPAPKRRKSSSTPSLKMTPSDAIRDSSTSSRSSVTSPITRLAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY81</accession>
    <name>Q1CY81_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adventurous gliding motility protein AgmG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">agmG</name>
        <name evidence="2" type="ORF">MXAN_6519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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            <begin position="638"/>
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    </feature>
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            <dbReference type="EMBL" id="ABF92074.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="712" mass="76696" checksum="C05C553720403362" modified="2006-07-11" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Miller N."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="253" mass="28158" checksum="2AADC0812F762AC3" modified="2006-07-11" version="1">MQFQARCELQRRQWLGSRWHVRCFGGPQAGWTPCREPDVRVQQRHTAATRRDWFDMVKISFLIDSTKLPTGGSSVSTAVAVSHQTFLVNDNPHPNQNDPDYAVPVPSGESVRIYIQEANYASTVGLAPNGIIVHAFNGAPVSDAIMNDATKRPIDIPNFDLDLGPIPDFIGFVGDSPKWTQTPPSWSNWPNEPLIDQQLRAGWTPTFVPYITFNASKLVSGLLEYGVVFALTKDGANVQYFYFDPFLKIGSSS</sequence>
</entry>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
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                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
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                <person name="Sullivan S.A."/>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Eisen J.A."/>
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                <person name="Barbazuk W.B."/>
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                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="364" mass="38363" checksum="3AAC071E3DD150FC" modified="2006-07-11" version="1">MGGVAVGVGALGRPPGGGEAGGRMKPARWPADRPEEGRLLHVEPRARRYRDTRVADLPSLLRAGDLLVVNDAATLPASLVGRTESGERIELRLLSREPDGTWTGVLFGAGDWRRRTEDRPPPPVLAVGAGLVVGGLKALVVAVLPPSPRLLRVAFDATGAALWSGLYRSGRPVQYAYLEAPLSLWHVQTAYGARPWSVEAPSAGLPLTWSVLLTLRKQGVRLASLTHAAGLSSTGDAALDAALPWPERSDIPAATVEAVLHTRASGGRVVAVGTTVVRALEGRAARHGGWLVAGEEVTDLLLGPGFVPRLVHGLFTGVHEPGSRHHALLQAFAPLPLLQEVAAHAEARGYLGHEFGDSCLLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ52</accession>
    <name>Q1CZ52_MYXXD</name>
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        <submittedName>
            <fullName evidence="8">Transporter, solute:sodium symporter (SSS) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556134.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6190"/>
    <dbReference type="EnsemblBacteria" id="ABF86910">
        <property type="protein sequence ID" value="ABF86910"/>
        <property type="gene ID" value="MXAN_6190"/>
    </dbReference>
    <dbReference type="GeneID" id="41363419"/>
    <dbReference type="KEGG" id="mxa:MXAN_6190"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_11_4_7"/>
    <dbReference type="OMA" id="ILSYKSH"/>
    <dbReference type="OrthoDB" id="231452at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="570" mass="61897" checksum="47A41DF808E6EC7F" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZF0</accession>
    <name>Q1CZF0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase, subunit III</fullName>
            <ecNumber evidence="9">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">coxC</name>
        <name evidence="9" type="ORF">MXAN_6088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556037.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6088"/>
    <dbReference type="EnsemblBacteria" id="ABF92259">
        <property type="protein sequence ID" value="ABF92259"/>
        <property type="gene ID" value="MXAN_6088"/>
    </dbReference>
    <dbReference type="GeneID" id="41363324"/>
    <dbReference type="KEGG" id="mxa:MXAN_6088"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_1_0_7"/>
    <dbReference type="OMA" id="SESLMFG"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="24577" checksum="ED8AE680AB76E2CA" modified="2006-07-11" version="1">MQSSSHAAGGAALPVPRLAGHFASLEVQNHAARLGMWLFLATEILLFAGLFICYGVYRFLFPEAWAAASRSLDLTLGTVNTVVLITSSLTAALAVHYAKEGKNKMVAVQIGLTLVMAVGFLVIKYFEYHHKFEIGTLPGRFYSYEGIQLPGVPLYFTVYFCATALHGIHVVIGMIVLAFSMVRALKKADFGPNNYTMVELGSMYWHLVDLVWIFLFPMLYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZJ5</accession>
    <name>Q1CZJ5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_6043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555992.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6043"/>
    <dbReference type="EnsemblBacteria" id="ABF89024">
        <property type="protein sequence ID" value="ABF89024"/>
        <property type="gene ID" value="MXAN_6043"/>
    </dbReference>
    <dbReference type="GeneID" id="41363281"/>
    <dbReference type="KEGG" id="mxa:MXAN_6043"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="PWPRALN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="545" mass="57448" checksum="44CD7B2794D823E0" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZK8</accession>
    <name>Q1CZK8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheW-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555979.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6030"/>
    <dbReference type="EnsemblBacteria" id="ABF88929">
        <property type="protein sequence ID" value="ABF88929"/>
        <property type="gene ID" value="MXAN_6030"/>
    </dbReference>
    <dbReference type="GeneID" id="41363268"/>
    <dbReference type="KEGG" id="mxa:MXAN_6030"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480532_0_0_7"/>
    <dbReference type="OMA" id="LCALDCE"/>
    <dbReference type="OrthoDB" id="1681888at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="182" mass="19900" checksum="8D532EF326D96733" modified="2006-07-11" version="1">MKVTPRTLEAAQEAEALELLERRASRLREQGENTVEEAVHWIAEFPLGEERYALSLESLRAALPLKMVSPVPLSAPHVVGVLRFQGQVLAALSLASLLGGHGWRQDPAVLLVVDRGDGELCALDCEAIPRPTTLPMSAVEAARVRAEGAVMEVFTQDRQLIHLIDLKRLFSATRGTGARHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ6</accession>
    <name>Q1CZQ6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">MXAN_5982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5982"/>
    <dbReference type="EnsemblBacteria" id="ABF90199">
        <property type="protein sequence ID" value="ABF90199"/>
        <property type="gene ID" value="MXAN_5982"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5982"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_3_7"/>
    <dbReference type="OMA" id="FSHGAME"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="97"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="10">
        <location>
            <begin position="306"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="11">
        <location>
            <begin position="606"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="939" mass="103251" checksum="047EA0607B96025B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZV3</accession>
    <name>Q1CZV3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase, M48 (Ste24 endopeptidase) family</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_5933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555884.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5933"/>
    <dbReference type="EnsemblBacteria" id="ABF92574">
        <property type="protein sequence ID" value="ABF92574"/>
        <property type="gene ID" value="MXAN_5933"/>
    </dbReference>
    <dbReference type="GeneID" id="41363171"/>
    <dbReference type="KEGG" id="mxa:MXAN_5933"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_5_2_7"/>
    <dbReference type="OMA" id="QWEVNLI"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="82"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="274" mass="29200" checksum="08C3315C9E2D77EB" modified="2006-07-11" version="1">MQRILVAVLGVTLALGLSTGCTKQRISAEKAVARTLISDEQEEQLGKQVKAELETKEKIKYVQNAAVVDYVRGISTSILNQASKDRPGVKWKINVIDDPKTVNAFATPGGYLYVYTGLILAADTEAELAGVMAHEAGHVVGRHSARAMVNQMGLQAITQAALGQNPGTVAQIAASLVSGGTLLAHGRGEEIEADEYGARYASGAGYDPRGLITFFEKLQKEQGDTPALMKWLSTHPTNRDRIVNIQKIISQKNLRGSNNGPGGLPAIKQALGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZY4</accession>
    <name>Q1CZY4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="4" type="ORF">MXAN_5902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555853.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5902"/>
    <dbReference type="ESTHER" id="myxxd-q1czy4">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88432">
        <property type="protein sequence ID" value="ABF88432"/>
        <property type="gene ID" value="MXAN_5902"/>
    </dbReference>
    <dbReference type="GeneID" id="41363140"/>
    <dbReference type="KEGG" id="mxa:MXAN_5902"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_1_0_7"/>
    <dbReference type="OMA" id="WDQARSI"/>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="93"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="47965" checksum="A852517F67CF950F" modified="2006-07-11" version="1">MPTTHLPAPRVFDVSLPDLTLEAGARITNHLVRGWWWGPAEDVAWLESRARVLSEDEARASALRVVRRTVAEQQALAAEARHRGPARAPAPVPTVLLVHALTGDMRAGSKGGWWEPLIGPRRALDPSRVRLLCFNNLGSCYGTSGPADEGFPLRTDDARFGPPLPLPKGDLRQDEQRLPATVTPWDQARSILLAMDALGLDDVELVTGGSLGGMVVLCLAALAPERFARLFPIATTESATAWVVGLNHVARQALLMDPGFPESPHRGLELARQLAMLTYRAEPGLEALQGRPAEWSSRALHPMHSYLEYQGQKLESRFDARAYLAQLGAMDHHDLSRFPGGGLARIRASALCVGIDTDQLFFPSHMATLTRRLREHGLHAEHATLSSQHGHDGFLLEWDAMAVLLARALALPTARGPEHAFPRWPEVRPALNPPCGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D012</accession>
    <name>Q1D012_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine dehydratase</fullName>
            <ecNumber evidence="7">2.5.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ilvA</name>
        <name evidence="7" type="ORF">MXAN_5874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555825.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5874"/>
    <dbReference type="EnsemblBacteria" id="ABF87380">
        <property type="protein sequence ID" value="ABF87380"/>
        <property type="gene ID" value="MXAN_5874"/>
    </dbReference>
    <dbReference type="GeneID" id="41363113"/>
    <dbReference type="KEGG" id="mxa:MXAN_5874"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_7"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="331"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="43712" checksum="437888A50D7970E8" modified="2006-07-11" version="1">MVTLEDIQAARERLRSAIRPTPCPQSDYYTERTECAAVFFKLENLQRTGAFKERGALNKLLTLTEDERRRGVIAASAGNHAQGVAYHARRLGVSATIVMPERTPLIKVSRTRDDYGARVVLKGTNYDEAYAEALRIQKAEDRVFIHPFNDAHVIAGQGTIGLELLEQCPDLEVVLVPIGGGGLISGIACALKETRPDIRVVGVQAETIASMKASVEAGERVLLAAAGTTIADGIAVKRVGDLTFPMVQKYVDEVVAVDEEEIAAAILTLLEQEKSVVEGAGAVGLAALLSGDVPAARGRRTAIILSGGNIDMNVISRIIERGLVKAGRLVQLEVRLPDRPGMLAKLTTQVADLRANVVEIHHERAFSKAGLGEAMVEVTLETTGPAQIEELERALHRLGWQVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D040</accession>
    <name>Q1D040_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555797.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5846"/>
    <dbReference type="EnsemblBacteria" id="ABF86555">
        <property type="protein sequence ID" value="ABF86555"/>
        <property type="gene ID" value="MXAN_5846"/>
    </dbReference>
    <dbReference type="GeneID" id="41363084"/>
    <dbReference type="KEGG" id="mxa:MXAN_5846"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048984_0_0_7"/>
    <dbReference type="OMA" id="GLRVYPC"/>
    <dbReference type="OrthoDB" id="397741at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="265" mass="29332" checksum="ABDE5381954682AB" modified="2006-07-11" version="1">MNYTDYAKRIRAHAQVADVSEYGRVTEGDQDYPLFRLVVPGERWLVITSGFHGEEPAGPLTLAEHFPAVAAYAVERGVGLRVYPCINPSGFEAGTRYNRSGEKPNNDFLRYEVAPGEWVGELNVARPILRWALYDEGPKETRAIRSELARYAAPAAALDIHQDDYLGGASTYAYTFGDKAAYRPLVEASAKHVAVVRSQKVDDHSFTDADGLIEYHDGSVTDWYSRQGVPYTAALETTTPTPRDVCDAVNLIWIRGFIDLVARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D081</accession>
    <name>Q1D081_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555756.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5805"/>
    <dbReference type="EnsemblBacteria" id="ABF88812">
        <property type="protein sequence ID" value="ABF88812"/>
        <property type="gene ID" value="MXAN_5805"/>
    </dbReference>
    <dbReference type="GeneID" id="41363046"/>
    <dbReference type="KEGG" id="mxa:MXAN_5805"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098624_0_0_7"/>
    <dbReference type="OMA" id="NNDWQTE"/>
    <dbReference type="OrthoDB" id="1242745at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188058" evidence="1">
        <location>
            <begin position="37"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="222" mass="23628" checksum="076A66C7C92760BE" modified="2006-07-11" version="1">MASFPVTDFPGRNAMRRSIVGGAAAAALGMAGPAFAIEAQQVGERLRVKERPLVGVDVRLGLGNFTGDLGSNTKVGPLLGINASAYPWQYGGVEVGYEGQRFPIDDSRLRNNGDGEGVWRHNATLLAKAGPLIDEKWRPFVGAGVGLSYLNPSDGADRFYNNDWQTELPLAAGLDYRFGNLVAGARATYRFVGGEGLLRNPITNADEKGSLLNGNVMIGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0C5</accession>
    <name>Q1D0C5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555712.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5761"/>
    <dbReference type="EnsemblBacteria" id="ABF92459">
        <property type="protein sequence ID" value="ABF92459"/>
        <property type="gene ID" value="MXAN_5761"/>
    </dbReference>
    <dbReference type="GeneID" id="41363004"/>
    <dbReference type="KEGG" id="mxa:MXAN_5761"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047487_2_0_7"/>
    <dbReference type="OMA" id="FRMPVIG"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="48081" checksum="776A00B627E989E3" modified="2006-07-11" version="1">MFYAFVRAVVALCLRLFYRVKVNAPALEPDGPVLFVGNHPNGLIDPALVFILTRRKVTFLAKAPLFRMPVIGWLLKGLDALPVYRKQDDPAKMGGNEGTLEAAKGALVQGRAITIFPEGKSHSEPGLAELKTGAARIAVSAAKAGAPVRIVPVGLTYAEKHVFRSEVLIDVGPAIDVQDFLPADAAAEPDAVRALTERIASGLRAVTLNLEQWADLPLAQLAEQLFAFKQGGALDAERLRLWARGVQMFRAQEPERFESLRAQLAGFRHRMALVQATGLEDLALVYRPGNVVPFVVKNVLALALGLPLFALGLGLFWLPYQLPRLASRNAELDVQATVKFLTAFVVALVWWGVLTAAAAVWGSALLSVAVFLAVPPLALFTLYFAERWESLQRDIRVFFTLGNRARLKRLLLADGERLALEMERLADEYRPRLDAAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0N5</accession>
    <name>Q1D0N5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">MXAN_5649</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FliM family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555603.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5649"/>
    <dbReference type="EnsemblBacteria" id="ABF92730">
        <property type="protein sequence ID" value="ABF92730"/>
        <property type="gene ID" value="MXAN_5649"/>
    </dbReference>
    <dbReference type="GeneID" id="41362895"/>
    <dbReference type="KEGG" id="mxa:MXAN_5649"/>
    <dbReference type="eggNOG" id="COG1868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773449_0_0_7"/>
    <dbReference type="OMA" id="TRELGCP"/>
    <dbReference type="OrthoDB" id="1018449at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013385">
        <property type="entry name" value="T3SS_SpaO/YscQ/SpaO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02551">
        <property type="entry name" value="SpaO_YscQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="13">
        <location>
            <begin position="350"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF92730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="416" mass="43805" checksum="EC657EBECEA836A7" modified="2006-07-11" version="1">MRGCHVFPTPRLHELGPWRGLCTGGVRLDAAAEPPMNTRIEHAASRKVRPLRRLGARRLTRAHLVLAERPQAGSLGREALDAVMAALTRELGCPVHAEARILESVVSPSVGLGEPAIFALLELSAVGGTAVLELEPALAFMGLERIAGAGQRPGVVTELARLEEATLAYVLLVALSAVRAAGGAYPWLGPRLAGVTMSRSDVVARLDPREPLVGIELMVTVGESRAGARLLLPSQVVQTVFQALPVERAPGIAPEVLAASLEARCLVGQTPLSANALDALVVGDVVVFEGVRTQAGQLFGPGRLVTRGFALSGDFLAEGFSLTRAQGRGIPQESDMVVVNKQEEGMPPLPVDVEIELTRVMIPLSELAALKPGALLPLHINASEPVVLRVGDRAVARAELVEIEGEVGARVLALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Y8</accession>
    <name>Q1D0Y8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Channel protein, hemolysin III family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_5546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5546"/>
    <dbReference type="EnsemblBacteria" id="ABF88508">
        <property type="protein sequence ID" value="ABF88508"/>
        <property type="gene ID" value="MXAN_5546"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5546"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_7"/>
    <dbReference type="OMA" id="YHRRVWS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="19759" checksum="680805763A6F1653" modified="2006-07-11" version="1">MMAPTDRAATAAAVFAVSLVVLFSVSATYHRVNWSTRGRTWMRRMDHASIFILIAGTYTPVALLGISGAAGNRLLLLIWAGALAGVLQSLFWIQAPKVVTAALAVAVGWTLVPYFDEARQALTGSNLALILAGGVAYTAGALAYALKRPNLRPGVFGYHELFHALTLVGAGLHFTVVLRLVRAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1G6</accession>
    <name>Q1D1G6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Siderophore transporter, RhtX/FptX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_5357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555322.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5357"/>
    <dbReference type="TCDB" id="2.A.1.57.4">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91935">
        <property type="protein sequence ID" value="ABF91935"/>
        <property type="gene ID" value="MXAN_5357"/>
    </dbReference>
    <dbReference type="GeneID" id="41362625"/>
    <dbReference type="KEGG" id="mxa:MXAN_5357"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029352_4_2_7"/>
    <dbReference type="OMA" id="GKFWGVV"/>
    <dbReference type="OrthoDB" id="1165704at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="PTHR12778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="403" mass="41775" checksum="45B333F793620B53" modified="2006-07-11" version="1">MRTATKLGLLSSLYLSQGLPFGFFTQALPVLLRHQGLSLPSIGLAHLLALPWALKFLWAPPMDRHGSARWGRRRGYILPLQCLSSGLLLALALPEGGLDMRLLMAAVLGINLLAATQDVATDGLAVDLLAPAERGWGNGIQVAAYRVGMILGGGVMLAVFDAVGWRPTFLALGTLLLLATVPIALFREPPTAPPPAQSLGLRWWLKRPGAAAWLTLLVVYKAGEALATGMLRTFLVDEGLSLTAIGWLLGGVGFTAGLVGALLGGGLVVRLGRRRALLVFGGIQAGAVLLYALAARGPTSLPLLTLVCGVEYVASGMATAAVFTAMMDACRPDHAATDYTVQASLVVLATGAAAALSGFSAQALGYAGHFTLAALLCAAGTLYAALTFHPPRSLASEAAPEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Q8</accession>
    <name>Q1D1Q8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-70 factor, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555230.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5263"/>
    <dbReference type="EnsemblBacteria" id="ABF89745">
        <property type="protein sequence ID" value="ABF89745"/>
        <property type="gene ID" value="MXAN_5263"/>
    </dbReference>
    <dbReference type="GeneID" id="41362540"/>
    <dbReference type="KEGG" id="mxa:MXAN_5263"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_3_7"/>
    <dbReference type="OMA" id="ERTVCAC"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="189" mass="20892" checksum="52B178D532137380" modified="2006-07-11" version="1">MCEAGAMSPEVLALLLQNRQRFLAFLTPHVGSVEAAEEVLQAALLKSVERGSTLREEERAVAWFYRLLRNALIDRYRHEQRQGRALRAFAEESPLSTEDAAELERTVCACVSTLTTTLKPEYSDALQRVDLDGQTLAEFAEAAGITHTNAKVRLHRARQALGRRLEQACGTTCCRKGCVDCPCEEAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Z8</accession>
    <name>Q1D1Z8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_5172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555143.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5172"/>
    <dbReference type="EnsemblBacteria" id="ABF89188">
        <property type="protein sequence ID" value="ABF89188"/>
        <property type="gene ID" value="MXAN_5172"/>
    </dbReference>
    <dbReference type="GeneID" id="41362455"/>
    <dbReference type="KEGG" id="mxa:MXAN_5172"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_2_0_7"/>
    <dbReference type="OMA" id="PTLRCDH"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="87"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF89188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="501" mass="56668" checksum="DD61D0B8BE0170DD" modified="2006-07-11" version="1">MRVPGLRYRDEWLPNFFPAKQVGPDHFVRLSRTGAMQLLSGAENAQLDEISMDEALFERLEQTSHLITAQNSSRVLEDLKRWHDRTYAGPGLHIVVLSKRCNLNCTYCHMNPENISADSKRFDMQPDVADAIIRFALGSPAPFLGFEFQGGEPFLNFEGMKYFVEEARRQNEAVGKRLRFSVVSNLMVATDEHIAYCKENRINVSYSLNGPEDIHDSFRVTRSGAGSFRKVMERLSHFRDRFPGVLSASPLCVVGASNAKELKRTIDFYHAEGFKDLAILKLKALGNARKEKLPFDIQDFLHYYLDALDYIYEKNRQENENYSERVVRVVLAKILQSTDTGFVDWRNPVGDFGSAITYDHDGEILPSDEARSMRSEFGLGNVKGTTYDALIRNKATFRSMNLSLRDRDPQCRECAFNPYCGVLPVLDYARTGDATPRPHASEECLQTLAVVEWVLRKLVEDPIPLLRMMPGMDAALVEMANGLPTEPSSQAMPPMLSVQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D222</accession>
    <name>Q1D222_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chemoreceptor McP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcP2</name>
        <name evidence="6" type="ORF">MXAN_5148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555119.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5148"/>
    <dbReference type="EnsemblBacteria" id="ABF90272">
        <property type="protein sequence ID" value="ABF90272"/>
        <property type="gene ID" value="MXAN_5148"/>
    </dbReference>
    <dbReference type="GeneID" id="41362431"/>
    <dbReference type="KEGG" id="mxa:MXAN_5148"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_452514_0_0_7"/>
    <dbReference type="OMA" id="MARMRQD"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="323"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="605" mass="63858" checksum="44D3343FB3F819F3" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D284</accession>
    <name>Q1D284_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555059.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5085"/>
    <dbReference type="EnsemblBacteria" id="ABF89178">
        <property type="protein sequence ID" value="ABF89178"/>
        <property type="gene ID" value="MXAN_5085"/>
    </dbReference>
    <dbReference type="GeneID" id="41362369"/>
    <dbReference type="KEGG" id="mxa:MXAN_5085"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_1_7"/>
    <dbReference type="OMA" id="MAHTIDG"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="4">
        <location>
            <begin position="13"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="25749" checksum="BEA0FDF12476521F" modified="2006-07-11" version="1">MSPRVLLLAGLEPTGRAGLLADVAAVRALRGQPVAVPTAQTAQGVRTFTWTASPPRVLSAQVAAARELGPVHAVKCGMVPARAQLEAAQRALEDTGAWWVVDPVVRTSRGEPLTRLSARAYLSLAGPRVVLTPNLDEAGWLLGRPVARTVEEAVEAAEALAQHGFGAVLVKGGHLPDTQGLADVLATPGRVRVLEGKRLARAPGRRGTGCRLASALATELGRGRALETAVRSARALVLRYLRTGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2B2</accession>
    <name>Q1D2B2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555032.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5056"/>
    <dbReference type="EnsemblBacteria" id="ABF91135">
        <property type="protein sequence ID" value="ABF91135"/>
        <property type="gene ID" value="MXAN_5056"/>
    </dbReference>
    <dbReference type="GeneID" id="41362340"/>
    <dbReference type="KEGG" id="mxa:MXAN_5056"/>
    <dbReference type="HOGENOM" id="CLU_1000489_0_0_7"/>
    <dbReference type="OMA" id="QGFGYRA"/>
    <dbReference type="OrthoDB" id="1058597at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="317" mass="34100" checksum="32B93918EDD10679" modified="2006-07-11" version="1">MCGASVCSGVGVYPRAGAPQVKRRGWKWASRSYVRRAGDMNGTAQQGFGYRARRTFTRLLVFTLILGLGGVVVFLLSQLNARTFTLALQDGQLVVMKGRNAPMGAVPYRTGDPRLADAYAPVAIEGQDVSALLTRKFTDRDELDQALFPVLEGLARPRIASDEPARVDQGLYYLRRAEKLSGITEEQRLSLQKHMVDVAYYQARQKLEDARRLVSEALTQLKLAAESQSRHARSANQMLSAVAPPARDLEESLRRAVHTLSGPQAAPQAPSQPAPQPAPTAPSPAPTPQPETTGEALDGAPQAPTGTDAGGVVPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2K2</accession>
    <name>Q1D2K2_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554943.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4965"/>
    <dbReference type="EnsemblBacteria" id="ABF90227">
        <property type="protein sequence ID" value="ABF90227"/>
        <property type="gene ID" value="MXAN_4965"/>
    </dbReference>
    <dbReference type="GeneID" id="41362250"/>
    <dbReference type="KEGG" id="mxa:MXAN_4965"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625049_0_0_7"/>
    <dbReference type="OMA" id="VEGMAWE"/>
    <dbReference type="OrthoDB" id="510644at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="59"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="44204" checksum="74F88B563563972B" modified="2006-07-11" version="1">MATRPKATPRLASDAASLDLERPLAQGLSPSRPLQAWFHGPEGMVLLQEPPGFAGFLAGSLRTLSVEEVFAHVLSGIRSGLLAVQHATGRRTVSFRDGQVVFATSTERWERLGAALLRLGLLTQAQLTQALSRVTPSRRIGQVLTSEGLVSEANLYSAMTYVVREVVLSLFELEDGSFVFVEGPAPMADVVKLPERTRDLVLTGIKRAELVSRLRRRFPDDTRVTLGSEGPLPGESRLFARLADGLPLASLRASYEGGPHAFYTWLEEAVRGGNVAVHPAAPPPAQAPAVEGMAWELLSAEERYNLLLSLVHRALREAGKDTDLLRGFLDAPPQGLEDAYAGVTLAADGRVDVARLRANLSTGGEAVGRALTLEALDAFVSYALFSARNVLPADVAERLSNTYRTLQGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2U5</accession>
    <name>Q1D2U5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554853.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D2U5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4870"/>
    <dbReference type="EnsemblBacteria" id="ABF89124">
        <property type="protein sequence ID" value="ABF89124"/>
        <property type="gene ID" value="MXAN_4870"/>
    </dbReference>
    <dbReference type="GeneID" id="41362161"/>
    <dbReference type="KEGG" id="mxa:MXAN_4870"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_271777_0_0_7"/>
    <dbReference type="OMA" id="EEQAYPF"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1218" mass="137603" checksum="0640C05B764C6924" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2X5</accession>
    <name>Q1D2X5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucanase</fullName>
            <ecNumber evidence="8">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">celA</name>
        <name evidence="10" type="ORF">MXAN_4837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554823.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4837"/>
    <dbReference type="CAZy" id="CBM4">
        <property type="family name" value="Carbohydrate-Binding Module Family 4"/>
    </dbReference>
    <dbReference type="CAZy" id="GH6">
        <property type="family name" value="Glycoside Hydrolase Family 6"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91186">
        <property type="protein sequence ID" value="ABF91186"/>
        <property type="gene ID" value="MXAN_4837"/>
    </dbReference>
    <dbReference type="GeneID" id="41362133"/>
    <dbReference type="KEGG" id="mxa:MXAN_4837"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556456_0_0_7"/>
    <dbReference type="OMA" id="DRAPNTW"/>
    <dbReference type="OrthoDB" id="376372at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005142713" description="Glucanase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="9">
        <location>
            <begin position="53"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF91186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="492" mass="51516" checksum="A3B8EED0DFF8E653" modified="2006-07-11" version="1">MQPSNSAGSPFRRFTAPAALMLAAALTTACGPSEPPAPAEAEALGSRTDALTELVSNGTFNGGTVSPWWSGPNTQSRVENARLRVDVGGGTANPWDALIGQDDIPLVNGRAYTLSFTASASVSTTVRVTVQLESAPYTAPLDRQITLDGTSRRFTFPFTSTLATQAGQVTFQMGGRATGFSAFIDDISLTTEDGGGGGGPLSMTNGFYIDPNSNPANWVRANSGDSRAARIQSSVANNLAARWFAAWSGDITTAVSSFVSAADAADKLPVLVAYNIPGRDCGSHSGGGAGSPEAYRTWISSFAAAIGNRPAVVIIEPDAVAQLDCLANDAERQTRISLIRYATEQFRDRAPNTWAYLDAGNALWINADTMAQRLENMGVRNVRGFALNVSNFYTTAQSASYAGSVNSSLSSRYGYTKPFVVDTSRNGNGSNGEWCNPAGRKIGTTNQVGVGGAEMTLWIKVPGDSDGQCGVAPNTPAGTFVPDVALRMIDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2Z4</accession>
    <name>Q1D2Z4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter, ATP-binding protein</fullName>
            <ecNumber evidence="7">3.6.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysA</name>
        <name evidence="7" type="ORF">MXAN_4818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.25" evidence="7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554804.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4818"/>
    <dbReference type="EnsemblBacteria" id="ABF90096">
        <property type="protein sequence ID" value="ABF90096"/>
        <property type="gene ID" value="MXAN_4818"/>
    </dbReference>
    <dbReference type="GeneID" id="41362117"/>
    <dbReference type="KEGG" id="mxa:MXAN_4818"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="IVCEPRV"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041193">
        <property type="entry name" value="CysA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17850">
        <property type="entry name" value="CysA_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="38167" checksum="446A2D7E2C47D74A" modified="2006-07-11" version="1">MSIVVEQLARRFNRGGSPAVSKVSFQAPEGAITSLLGPSGAGKSTLLRLIAGLEIPDEGRVLIDGVDSTQMPVQQRGVGVVFQSYALFKHLTVRQNVAFGLEVRRVPKAEREARVEEMLRMVQLEHLGGRYPGQLSGGQRQRVAFARALAIRPRVLLLDEPFGALDTRVREELREWLHALHERTRLTTLLVTHDQQEALEISQHVVVLSEGRVAQAGSPSDIYDRPASPFVASFIGGASVLRGHVQAGRAAMGALSVTAPAAAREGEPVHAFVRPHDIKLAKAVAGAASASTATGRVERLKPVGGYVKVFLRLPSGDEVTVEVPRSEFDALGVAEGDSVRADVRSATVFVGDYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3A5</accession>
    <name>Q1D3A5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554693.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4706"/>
    <dbReference type="EnsemblBacteria" id="ABF86175">
        <property type="protein sequence ID" value="ABF86175"/>
        <property type="gene ID" value="MXAN_4706"/>
    </dbReference>
    <dbReference type="GeneID" id="41362006"/>
    <dbReference type="KEGG" id="mxa:MXAN_4706"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_7"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="292" mass="32305" checksum="DBC7BA4CD2F145DD" modified="2006-07-11" version="1">MLKSMTGFGAGRARVGDEEVSVELRSLNHKFCEVKVRLPRELSSQEPLVSKQVKDRLARGSVELLVKRQAPTASGTVPTVDLGLAREYVRAFRELASELGLPGDVAWSQVANQPGVVRLEEKGVELDSASQALQAALDQALTALEKMRQVEGEAIYADLDARVKLLEGWSKEVAQLAPKAVQEYQQRLTDRIAELASGVAVDPQRLAQEVALFAERTDIAEEVTRLASHLEQFRALMASNEPAGRRMDFLVQEMHREVNTTGSKSQHAEISVRVVAMKAEVERIREQVQNVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3G4</accession>
    <name>DXS_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="1">DXP synthase</shortName>
            <shortName evidence="1">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs</name>
        <name type="ordered locus">MXAN_4643</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554635.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D3G4"/>
    <dbReference type="SMR" id="Q1D3G4"/>
    <dbReference type="STRING" id="246197.MXAN_4643"/>
    <dbReference type="EnsemblBacteria" id="ABF90170">
        <property type="protein sequence ID" value="ABF90170"/>
        <property type="gene ID" value="MXAN_4643"/>
    </dbReference>
    <dbReference type="GeneID" id="41361943"/>
    <dbReference type="KEGG" id="mxa:MXAN_4643"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_7"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000256441" description="1-deoxy-D-xylulose-5-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="583" mass="61355" checksum="68B493ED18028EEA" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3L9</accession>
    <name>Q1D3L9_MYXXD</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
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        <name evidence="5" type="ORF">MXAN_4586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4586"/>
    <dbReference type="EnsemblBacteria" id="ABF89854">
        <property type="protein sequence ID" value="ABF89854"/>
        <property type="gene ID" value="MXAN_4586"/>
    </dbReference>
    <dbReference type="GeneID" id="41361886"/>
    <dbReference type="KEGG" id="mxa:MXAN_4586"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="317"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="532" mass="59250" checksum="DB559B8B2529C4C9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4G9</accession>
    <name>Q1D4G9_MYXXD</name>
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        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">MXAN_4279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DK1622</strain>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="329"/>
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        <location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF92582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="993" mass="112678" checksum="0B4CED2DBD0D7BE6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H5</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF86790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="405" mass="43797" checksum="282812F40621E17B" modified="2006-07-11" version="1">MTRTAPFHPEDAATPAAALHPLRDFAEKLGRELRFEDIRSGAWHARLVTAYVRHYEARRAGTTSAVRASETDALIRRASKEAALVGASAAGISTSAAMFTLDTGFVGALVAVPVAGSAMGLDTMLRSLIQARMMCDVASAFGVRIDPDDPWDLLHLNALTAGSETWEDADHGGAGLVGRMLTEDTEAAERKLGNRLMGEGVLRNLLPFASVLTSSVTSWRHTRRLGEASVEYARYRRALDDAFSAVRAVDARCVELLIEGAWCLFGTDGVLSSEATVMLAHLLRNSPSAARKRLLERLGEDEAQWVERLHEVPEPARDAFLHALEVIAAVDLSMSNAEWLLLRQAAAALNRPVRRERVQALLKQFRTHGVVRSPQGDSFEPRDGRMPSSPVAGLGADAHAAPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5I6</accession>
    <name>Q1D5I6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90082">
        <property type="protein sequence ID" value="ABF90082"/>
        <property type="gene ID" value="MXAN_3907"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3907"/>
    <dbReference type="HOGENOM" id="CLU_2771569_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="69" mass="7431" checksum="918B72DA4A5F9EFB" modified="2006-07-11" version="1">MRPSARRSMVSVRPPSQGRQRTSAPLWPATQTSAGPVPLSAFMGLDGAKAVLQAVPLKKWMLFVPELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5I7</accession>
    <name>Q1D5I7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553916.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3906"/>
    <dbReference type="EnsemblBacteria" id="ABF89184">
        <property type="protein sequence ID" value="ABF89184"/>
        <property type="gene ID" value="MXAN_3906"/>
    </dbReference>
    <dbReference type="GeneID" id="41361238"/>
    <dbReference type="KEGG" id="mxa:MXAN_3906"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027067_0_0_7"/>
    <dbReference type="OMA" id="DRLDNDC"/>
    <dbReference type="OrthoDB" id="357626at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021655">
        <property type="entry name" value="Put_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11617">
        <property type="entry name" value="Cu-binding_MopE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="652" mass="68621" checksum="CFEA5DCBE2C52527" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5J2</accession>
    <name>Q1D5J2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3901"/>
    <dbReference type="EnsemblBacteria" id="ABF90261">
        <property type="protein sequence ID" value="ABF90261"/>
        <property type="gene ID" value="MXAN_3901"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3901"/>
    <dbReference type="HOGENOM" id="CLU_1775455_0_0_7"/>
    <dbReference type="OMA" id="PADRHYI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="146" mass="16087" checksum="77E6F6C1E455B409" modified="2006-07-11" version="1">MALGVLLAAPPAWAEKPAKPTSRPADRHYIRKILPSKLPPKDKNTVIESRIDVSRDVKEINEGKAKKGNESGTVTWTIHKRTYGAHTNGTLFPIRGVGFHELNRGGFKALEVYNQFKDTPRATEIMDKIGIPPADRKAALKAHKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5V4</accession>
    <name>Q1D5V4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rumA</name>
        <name evidence="6" type="ORF">MXAN_3787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553800.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3787"/>
    <dbReference type="EnsemblBacteria" id="ABF87422">
        <property type="protein sequence ID" value="ABF87422"/>
        <property type="gene ID" value="MXAN_3787"/>
    </dbReference>
    <dbReference type="GeneID" id="41361119"/>
    <dbReference type="KEGG" id="mxa:MXAN_3787"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_8_2_7"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF87422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="431" mass="45950" checksum="10ACFBC443CBC6E6" modified="2006-07-11" version="1">MLPLPELPIELTIERLGQLGEGVASWQGRTVFIPGTFPGDTVRVHLETQGRVLRGILRQVVSPGPDRRDAPCVYASDCGGCDWLALAEPAQRSAKQEIVLSTLEHLGHLARDSFTVRPLLVAPRDWGYRRRAVLHPAGKGALGYFGRRSHERVPVEVCGALTPVLTALPGKLAPLLKPLAKDAEEVLLLAEGDKAAFAVNLSGPVTARHLEAAEAAVRALRLEGAVLTPKEGSARLLGKPALRSYSPLRPEVPLYLRPDAFAQAHAEANVGLVTSAVYELGARESDTVLELYSGNGNFTFPLAGTAASVLGVESSPVGVELAQRSAHEGGVTNVRFIQGDARKVCDGLVAEQRRFDVCLADPPRAGAPGLAKWMTALGVRRVVYVACDPASLARDAAGLVAAGYKPLALQVVDMFPQTHHVEAVMSFERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D688</accession>
    <name>Q1D688_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_3648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553666.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3648"/>
    <dbReference type="EnsemblBacteria" id="ABF89889">
        <property type="protein sequence ID" value="ABF89889"/>
        <property type="gene ID" value="MXAN_3648"/>
    </dbReference>
    <dbReference type="GeneID" id="41360985"/>
    <dbReference type="KEGG" id="mxa:MXAN_3648"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009433_1_0_7"/>
    <dbReference type="OMA" id="DRNNDPN"/>
    <dbReference type="OrthoDB" id="177018at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017800">
        <property type="entry name" value="ADOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
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        <location>
            <begin position="60"/>
            <end position="85"/>
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        <location>
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            <end position="376"/>
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        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
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            <end position="818"/>
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        </location>
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        <location>
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            <end position="426"/>
        </location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="ABF89889.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="836" mass="89137" checksum="6EC7EC1C8C79082C" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6A7</accession>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="198"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="425" mass="46468" checksum="0728F95E8BA24632" modified="2006-07-11" version="1">MAPPISPPLKALLLAMEYTPNVAGGVGTYVYELARGLARGGCKVTVLAYTPGEPAVLREPNLTVHMMPPSRGSLSQAGKLSLVGGIRVFNDDLIHRGRELIHEEKPDLIHFHQWHTHRAARALAHETGVPVLGTSHYISEPAERWWGQTPDPEILEEERSFYDGSTNVISVSDSMSELIRETYGMPASLLHTIHCGMDAGPFLQPSHAPEDYARLRATVATPDDPVVLYTGRLHPMKGISAIFAAAERVLERRPNVRFLLAGGTDSRESTQMVQTLTQRYAHLRHRIKLLGKLPRQQLGLLHRIADLALVPSLYEPFGYTAIEAMASGLPLVATRSGGPSEIVDHEKTGLLVPVLPGAPGGPREVDVESLAAAQLNLLEDRERARRMGLAGQQRVVELFSLPRMVAANLAVYQKLVGGQGREVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6D1</accession>
    <name>Q1D6D1_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3604"/>
    <dbReference type="EnsemblBacteria" id="ABF86151">
        <property type="protein sequence ID" value="ABF86151"/>
        <property type="gene ID" value="MXAN_3604"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3604"/>
    <dbReference type="eggNOG" id="ENOG502Z7VT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019647_0_0_7"/>
    <dbReference type="OMA" id="FMAYNNG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="690" mass="76905" checksum="E4566484090A5CDF" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6M0</accession>
    <name>Q1D6M0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Signal peptidase I</fullName>
            <ecNumber evidence="5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">MXAN_3509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553539.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3509"/>
    <dbReference type="EnsemblBacteria" id="ABF90779">
        <property type="protein sequence ID" value="ABF90779"/>
        <property type="gene ID" value="MXAN_3509"/>
    </dbReference>
    <dbReference type="GeneID" id="41360854"/>
    <dbReference type="KEGG" id="mxa:MXAN_3509"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684600_0_0_7"/>
    <dbReference type="OMA" id="SDSRFWG"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="186"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF90779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="418" mass="46436" checksum="AC8B7F7F247ADC07" modified="2006-07-11" version="1">MNAAMPSATPPAKLSEAMAARRTPEMLRARNVLVWRERLTSLWAPLIILALLYVPYTVIIEYSRASAVWAQPVMKGLGLLLVLYFVALLVWRNVSPKEKALRGVRHDANELLEENERILRKPGVSAKVAGPVLDRIAEQALRVEQASAAGDAEQLRTEVKGLEALTAQHLGAFRKQSAMDFLGGFGKALLVALVFRTFIVEPYRIPSGSMLPTLEIGDQVFVNKFIYGVRVPFLNFVPFVIVRPPERGDVIVFNNPVNESVDYIKRVVGVPGDVVEFINGVVHINGQPQKRELVSNEFTVHNITDDGRWYDQQETLYEENLSGVAHAALQTLPRMPRREGPYEVPPGHVFAVGDNRDNSADSRHGLGVTGYGKAEYVPYGHIKGKAMVVWLSLGYHGLLHGLFGGTGLRVDRFFEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6Z2</accession>
    <name>Q1D6Z2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553417.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3384"/>
    <dbReference type="EnsemblBacteria" id="ABF89629">
        <property type="protein sequence ID" value="ABF89629"/>
        <property type="gene ID" value="MXAN_3384"/>
    </dbReference>
    <dbReference type="GeneID" id="41360731"/>
    <dbReference type="KEGG" id="mxa:MXAN_3384"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_7"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="185" mass="19772" checksum="D63E053CBE3BB51B" modified="2006-07-11" version="1">MRIVAGTAKGRALAGPKSSSLHIRPTADRVRETLFNVLGQFLDGQRVLDLYAGTGALGLEAVSRGAGQAVLVDQDREALTLCRENAQAVGLAGQVEVLAAPVARALETLKRRGDRFELIFADPPYAARVVETVLDGIVAAGLLTPSGMVVVEHDKREAAPDTHAGLDREDQRRFGDTLVSFYRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D783</accession>
    <name>Q1D783_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553336.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3291"/>
    <dbReference type="EnsemblBacteria" id="ABF89741">
        <property type="protein sequence ID" value="ABF89741"/>
        <property type="gene ID" value="MXAN_3291"/>
    </dbReference>
    <dbReference type="GeneID" id="41360644"/>
    <dbReference type="KEGG" id="mxa:MXAN_3291"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1146245_0_0_7"/>
    <dbReference type="OMA" id="QESGIAW"/>
    <dbReference type="OrthoDB" id="912069at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="243" mass="26759" checksum="3D557E68E79318D1" modified="2006-07-11" version="1">MGLLDIFTGGSGPEKALKLKPKVTQKYGDPATRQKAIQQLGEMKVPEAVSVLLSRFTLTVDPLTTDADEKEHTFELVKSFGKDVAVPPILEFLRTSEQAASWALRLLGELTSEEETITACVSALQHLSAHYTRNPEKKVVLLHHVAGSQDPRIPPTVVPFLEDMSDDVKIAALKALGVFKYEPAREPMLKLLTADETARRVQTSVLSALAEGGFSVEGYREKVEPLLVEPYALGNDQRIQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7E2</accession>
    <name>Q1D7E2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, DegT/DnrJ/EryC1/StrS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553277.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3232"/>
    <dbReference type="EnsemblBacteria" id="ABF85969">
        <property type="protein sequence ID" value="ABF85969"/>
        <property type="gene ID" value="MXAN_3232"/>
    </dbReference>
    <dbReference type="GeneID" id="41360586"/>
    <dbReference type="KEGG" id="mxa:MXAN_3232"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059313_2_0_7"/>
    <dbReference type="OMA" id="FYFARNA"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="42852" checksum="EE480C1C4D507029" modified="2006-07-11" version="1">MKHSGRLFVPSLPTLWPHMLLSRPKPGELPPFSSPNVRYFYFARNAIWLTVKMLGLDSGEVLMPAYHHGVEVEALVDAGATPRFYRVGSRWDVDLDDVARRIGPKTRALYLTHYAGFPGPVAEMRKLADQHGLILIEDCALSLLSSDGAVPLGTTGDVGIFCLYKTLPVPNGGALVVNGPRQYSLPEPPAPPSVSTFSHTVSALLQNLELRGGLAGRALRSAVRTLGHGTVKAANIERVATGTQHFDRKHVDLGMSPLTKRIAQAQDLESIVEQRRRNYFFLLGRLRDISAPLFNQLPPGACPLFYPLVVQDKAEVLARLRVQGIDAIDFWKRFHPACDASAFPEVAQLRRSIVEIPCHQDLTPEVMADVAQAVREAVKSDHRSKKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H5</accession>
    <name>Q1D7H5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3197"/>
    <dbReference type="EnsemblBacteria" id="ABF87683">
        <property type="protein sequence ID" value="ABF87683"/>
        <property type="gene ID" value="MXAN_3197"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3197"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365577_0_0_7"/>
    <dbReference type="OMA" id="LYFSFFN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="393"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="714" mass="78518" checksum="33285DAC5BFCC211" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D801</accession>
    <name>HSLU_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslU</name>
        <name type="ordered locus">MXAN_3013</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D801"/>
    <dbReference type="SMR" id="Q1D801"/>
    <dbReference type="STRING" id="246197.MXAN_3013"/>
    <dbReference type="PRIDE" id="Q1D801"/>
    <dbReference type="EnsemblBacteria" id="ABF90379">
        <property type="protein sequence ID" value="ABF90379"/>
        <property type="gene ID" value="MXAN_3013"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3013"/>
    <dbReference type="eggNOG" id="COG1220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_7"/>
    <dbReference type="OMA" id="KYGMIKT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000125445" description="ATP-dependent protease ATPase subunit HslU">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <sequence length="459" mass="50896" checksum="23ED83A5E76476C8" modified="2006-07-11" version="1">MSAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTGVGKTEIARRLAKLAQAPFVKVEASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVGPRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQRVSDSAREKFRAQLRAGTLDDVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRKEEAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPIVEGSTINTKYGVVKTDHMLFIAAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRILREPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQANESTANIGARRLHTILERLLDEVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8F7</accession>
    <name>Q1D8F7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552916.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2855"/>
    <dbReference type="EnsemblBacteria" id="ABF89299">
        <property type="protein sequence ID" value="ABF89299"/>
        <property type="gene ID" value="MXAN_2855"/>
    </dbReference>
    <dbReference type="GeneID" id="41360225"/>
    <dbReference type="KEGG" id="mxa:MXAN_2855"/>
    <dbReference type="HOGENOM" id="CLU_194381_0_0_7"/>
    <dbReference type="OMA" id="CTPCPPY"/>
    <dbReference type="OrthoDB" id="2032468at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027635">
        <property type="entry name" value="Lantibiotic2_lead_pep_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03898">
        <property type="entry name" value="lanti_MRSA_kill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="69" mass="7735" checksum="6A9557AFB49B83C5" modified="2006-07-11" version="1">MSKKEHILRAWRDPEYFNSLSSEERAALPANPAAELELSDEVLESISGADSCEQFGSYYCTPCPPYVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8J4</accession>
    <name>Q1D8J4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552879.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2812"/>
    <dbReference type="EnsemblBacteria" id="ABF88354">
        <property type="protein sequence ID" value="ABF88354"/>
        <property type="gene ID" value="MXAN_2812"/>
    </dbReference>
    <dbReference type="GeneID" id="41360188"/>
    <dbReference type="KEGG" id="mxa:MXAN_2812"/>
    <dbReference type="eggNOG" id="ENOG503174J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187638_0_0_7"/>
    <dbReference type="OrthoDB" id="2016898at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="91" mass="10142" checksum="EEB4325BBFBC1897" modified="2006-07-11" version="1">MKQGCLVIRRRRSFPAAFFMEALTLSTDQKGTRILARTFFNQLRASGYTPHQVIGIATELLELVTADIKEGDKATAVQAAQEQAPERRPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8P9</accession>
    <name>Q1D8P9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase IV, X family/PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_2757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2757"/>
    <dbReference type="EnsemblBacteria" id="ABF88108">
        <property type="protein sequence ID" value="ABF88108"/>
        <property type="gene ID" value="MXAN_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2757"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="3">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="480" mass="52649" checksum="207EA6AC7293F725" modified="2006-07-11" version="1">MPDVGPKKVATLWRELQVSSIEELERACREGRVRQVRGFGAKSEAKMLEGIALYRRARGERKLLGEVLPVATALLERVKAAPGVVRASLGGSVRRQAETVADVDIIASAPEAGPVLDALANAPGVAAVLGKGESKCSVRLEAGDLQVDLRVLPDEDFATALHHFTGSKAHHIRLRNLGQERGLKISEWGVHRDDGTKVPVTDESGLYALLDMQYVPPELREDNGEVEAAREGQLPQDLLTLEDVQGAVHAHSTWSDGRNSLEEMALAARALGLKYLTVTEHSEAAIYAGGLKVDDLKRQWEEIDRINAAVSGVRLLKGIEVDILESGALDYADSVLEQLEVVIGSIHVRHGMDEDQMTRRLLAAMDNPCLQILGHPTGRLINSREPYPVRMDEVLERAAERGVAVEVNGKPARLDIKAEYVRQAVKRGVRLVVSCDAHQKEDLRNLAFAVATARRGWARKGDVLNTLPTDRFVTALRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8V8</accession>
    <name>Q1D8V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552766.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2698"/>
    <dbReference type="EnsemblBacteria" id="ABF88804">
        <property type="protein sequence ID" value="ABF88804"/>
        <property type="gene ID" value="MXAN_2698"/>
    </dbReference>
    <dbReference type="GeneID" id="41360076"/>
    <dbReference type="KEGG" id="mxa:MXAN_2698"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_1_7"/>
    <dbReference type="OMA" id="GKPYIAF"/>
    <dbReference type="OrthoDB" id="1238555at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="360" mass="38707" checksum="E914154C726F813A" modified="2006-07-11" version="1">MTDDLLLETRGAVGVVTLNRPKALNALNLGMCRKLHPALDAWAADPSIQAVVIRGAGGRAFCAGGDVRAVALSVGDASAEAKERVSREFFRAEYGLNHRIHYFGKPFIALVDGVCMGGGLGLSIHGTHRVVTEKLVLAMPETAIGLFPDVGGGWFLPRFPGESGTYLGLTGARCGAADAMWLGYATHHVESARLEAVLDALVGAPWGTGAASTVVDTVLAGFHADAGTSPLGVQRAAIDRCFAAERVDDIQQALELEGTPWAQETWATLLHMCPASLKVTLRQLRMGRTRDYDEMANVEYRLSQSMTARPDFREGIRAVLVDKDNKPHWRPSTLAEVTEGMVEALFAPLLHDTWKVPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D954</accession>
    <name>Q1D954_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552670.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2600"/>
    <dbReference type="EnsemblBacteria" id="ABF92120">
        <property type="protein sequence ID" value="ABF92120"/>
        <property type="gene ID" value="MXAN_2600"/>
    </dbReference>
    <dbReference type="GeneID" id="41359977"/>
    <dbReference type="KEGG" id="mxa:MXAN_2600"/>
    <dbReference type="HOGENOM" id="CLU_2058842_0_0_7"/>
    <dbReference type="OMA" id="KADCTCK"/>
    <dbReference type="OrthoDB" id="2012278at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188275" evidence="2">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="12786" checksum="D7294B5182D45F88" modified="2006-07-11" version="1">MTRIGMWVAGGLMASGLLLAPGAAEACEAHRRPAPETKAAEATPKAVEPSASGVERPLDVLDSLMAAKCQCGSKADCTCKKGSCDCSKCKKPKRQVMDALRGQPANLQFDEARYDASAGIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W1</accession>
    <name>Q1D9W1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2383 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87486">
        <property type="protein sequence ID" value="ABF87486"/>
        <property type="gene ID" value="MXAN_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2342"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148612_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019052">
        <property type="entry name" value="DUF2383"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09537">
        <property type="entry name" value="DUF2383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2383" evidence="1">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19973" checksum="9C5A0EF2F3571614" modified="2006-07-11" version="1">MEGGGEASPRCPCGSGHHLLRQAGFTRHPWRPSMASTNKDVETLNSFLRGEISAVETYRKAIGHVSDGLARDALEYCQHDHEHRIEEIRERILKMGGEPVESSGMWGTFAKLVQGGADVLGEKAAIQALEEGEDHGLADYQRDADQVHGENRRFVRMELIPAQKRTHERLSRLKRTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAA0</accession>
    <name>Q1DAA0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552278.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2201"/>
    <dbReference type="EnsemblBacteria" id="ABF89903">
        <property type="protein sequence ID" value="ABF89903"/>
        <property type="gene ID" value="MXAN_2201"/>
    </dbReference>
    <dbReference type="GeneID" id="41359589"/>
    <dbReference type="KEGG" id="mxa:MXAN_2201"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_7"/>
    <dbReference type="OMA" id="TEFHVYP"/>
    <dbReference type="OrthoDB" id="1361074at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="87"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="328" mass="35197" checksum="35FD6B9EA1128AD9" modified="2006-07-11" version="1">MTRPTSSTDFDPHLAPLLPPLKGYLPLQMTLEQLEHFRRLSHVTRDTLIGDAQVSCVDYSIPGYQGAEIVVSVIARQGHSVPGPAVYHIHGGGMVMGTRFAGAKPLVEWALRHDAVCVTVEYRLAPEHPAPTLVEDCYAGLAWMAAHADMLRFDPNQLVIFGGSGGGGLAAGTTLLARDRQGPRLLGQLLQCPMLDDRNETESAHRYDGVGVWDRTSNLTAWRAVLGDRCGGPEVSPYSAPARASDLSGLPPTFIDVGGAETFRDEAVAYARGILAAGGECELHVWGGAFHGFYDIAPQSDLARACIAARDAWIARMFARGAMSPCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAB3</accession>
    <name>Q1DAB3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2187"/>
    <dbReference type="EnsemblBacteria" id="ABF91448">
        <property type="protein sequence ID" value="ABF91448"/>
        <property type="gene ID" value="MXAN_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2187"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036077_0_0_7"/>
    <dbReference type="OMA" id="WAPWCQS"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="48641" checksum="3DF559FE524AD0D8" modified="2006-07-11" version="1">MRLAVGALLLLWGCATPPAIPQRPLPAKAGPVFLENDWEGALRAGREGRRPVLVEAWAPWCQSCRSMRATVLTSPALDAWADRFVWLAVDTDADTSMAFLQRYPVDTWPTFFVLEPEHGAVLARSLGAVSLPQFLGLLEQSERTFQQGRLGTEALVRADALALSGQHGEAAVAYQRALEQLAPEDARRAGALVSWSKSLAATGASADCMRVAASELPKLSRVDDRTRLLYVGMGCALDTNTDEARAVRGQFADEANRALGAPETELTPLQRSSLYELACEAREASGDEAGLRDQARTWWAFLQLQATHANGAEERAALDSHRVMATALLDQPDAAIPLLERSERELPGDYNPPARLATLYLMAGRKDEALTASKRALALAKGVSRGTVLAGHARILMAHGERAHAERLLTEALSEMDRTPGIPQDHLQRKVLERTLARLRASNGASPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAC4</accession>
    <name>Q1DAC4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_2176</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552254.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2176"/>
    <dbReference type="EnsemblBacteria" id="ABF92160">
        <property type="protein sequence ID" value="ABF92160"/>
        <property type="gene ID" value="MXAN_2176"/>
    </dbReference>
    <dbReference type="GeneID" id="41359569"/>
    <dbReference type="KEGG" id="mxa:MXAN_2176"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028595_0_0_7"/>
    <dbReference type="OMA" id="KELHWEE"/>
    <dbReference type="OrthoDB" id="555313at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="597" mass="64742" checksum="8680DCEFDCC51D5B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAC8</accession>
    <name>Q1DAC8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2172"/>
    <dbReference type="EnsemblBacteria" id="ABF91983">
        <property type="protein sequence ID" value="ABF91983"/>
        <property type="gene ID" value="MXAN_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2172"/>
    <dbReference type="HOGENOM" id="CLU_166796_0_0_7"/>
    <dbReference type="OMA" id="HRRVTRI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="119" mass="12929" checksum="2743BDAE01B5F2BB" modified="2006-07-11" version="1">MVACPEPHRRVTRIYQGQPQAPGDVVTAEETKSLQLVVGSLLGTAGVGVLTWAAKSLVGEIRALVEKVARQDERINALAVELGALRRWRDEFTRGLPAQVQQVVELELLRMSQSGGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAD5</accession>
    <name>Q1DAD5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552243.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92240">
        <property type="protein sequence ID" value="ABF92240"/>
        <property type="gene ID" value="MXAN_2165"/>
    </dbReference>
    <dbReference type="GeneID" id="41359561"/>
    <dbReference type="KEGG" id="mxa:MXAN_2165"/>
    <dbReference type="eggNOG" id="ENOG5032TZU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142708_0_0_7"/>
    <dbReference type="OMA" id="CDANMVY"/>
    <dbReference type="OrthoDB" id="1702154at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="13212" checksum="CEE25CE9DCBCE2F6" modified="2006-07-11" version="1">MATPTRFAFTQPSSPGTEFIIELTDENTIAHARRILSGEEKNEIHVHGRIIKRTQPYNPRFSFHLDPATIRFFEIAIEVCDANMVYVEDHLDEAGGAFLPGGHWCPWDSKLTREVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAF6</accession>
    <name>Q1DAF6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552222.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2144"/>
    <dbReference type="EnsemblBacteria" id="ABF90407">
        <property type="protein sequence ID" value="ABF90407"/>
        <property type="gene ID" value="MXAN_2144"/>
    </dbReference>
    <dbReference type="GeneID" id="41359543"/>
    <dbReference type="KEGG" id="mxa:MXAN_2144"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_7"/>
    <dbReference type="OMA" id="TFGTWLE"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="304" mass="32371" checksum="AD4689D6A054BE16" modified="2006-07-11" version="1">MSSNESVLVTAATGRQGGATARALLAEGGTRVRVMVRNPKAPNAKALAAAGAEVVVGDFDEPASLRAACAGARAVFSMQSPLISTTGVDYSKELQQGRNLVEAALAEGVETFVHTATSGVGDHRNVEGWAEGRWKSHETYWENKLATCDLVRSAGFKHWTLILPATFMDHPMLDPAGFVDGRRLLTVIRTDQTIALVAPEDIGTAAAAALNNPATFNGVTLQLASDLLTLPQIAEVLSRLDGKEYIVQFSTVEEAVAAGLHPGVAQGLTYMNVAPVLARPEIARSYGLSPMSFETWARQRREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAH9</accession>
    <name>Q1DAH9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate kinase 2, internal deletion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2119"/>
    <dbReference type="EnsemblBacteria" id="ABF88173">
        <property type="protein sequence ID" value="ABF88173"/>
        <property type="gene ID" value="MXAN_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2119"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1561269_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="88"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="171" mass="20053" checksum="672FA090D7D9F118" modified="2006-07-11" version="1">MAPDTHTEPMKRKAYEKELRRLQAQLCMLQDWVKQEGVRVVVVFEGRDAAGKGGTIRAITERVSPRVFRVVALPVPSDREKTQMYPWTRWYDYSQARDMMLAATDTPYAPWFILRSDNKKKARLNCIRFLLEKIPHKRVKRPEAKLPRRSKRGAYDDEASLAGKNFIPERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAN2</accession>
    <name>Q1DAN2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552146.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2062"/>
    <dbReference type="EnsemblBacteria" id="ABF90935">
        <property type="protein sequence ID" value="ABF90935"/>
        <property type="gene ID" value="MXAN_2062"/>
    </dbReference>
    <dbReference type="GeneID" id="41359471"/>
    <dbReference type="KEGG" id="mxa:MXAN_2062"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933272_0_0_7"/>
    <dbReference type="OMA" id="GRYRWTV"/>
    <dbReference type="OrthoDB" id="1095596at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="31794" checksum="18BD992D19556E6A" modified="2006-07-11" version="1">MKAALLLLTWLGTTPPGTVVVGPNESLRQVAQRTLGDARAAEELRALNGLSSDDVAAGTRLKVPGHERVLAQKALETARTLVASSKDASVPPAASSRLKVAESHFREARYTQAASEANAVGKLVAADRSPQSSAFTVEVGDGDSTTVTVKHGPPVRVEAEGVAQPVAKGESIRVEKGHPPPAPLRPLVAPSPGQPEDSARLKRRPDRDGHLGPVKLTWEAVRGAERYEVEVSRAQEQRAVFTQTVTSLEAKLPVLPAGSYRWTVRAVGPAGPSEPSAPRHFELVSERLKLEVKKGQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAT7</accession>
    <name>Q1DAT7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552091.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2001"/>
    <dbReference type="EnsemblBacteria" id="ABF90963">
        <property type="protein sequence ID" value="ABF90963"/>
        <property type="gene ID" value="MXAN_2001"/>
    </dbReference>
    <dbReference type="GeneID" id="41359411"/>
    <dbReference type="KEGG" id="mxa:MXAN_2001"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852334_0_0_7"/>
    <dbReference type="OMA" id="HNLGPQK"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="312" mass="34386" checksum="D0B84E04AA8B92D8" modified="2006-07-11" version="1">MDTQKTYALKFISGKYQGGEFPLKADKQIVIGRSSELDMVLVEDMVSRKHARISFSDGSITIEDLGSTNGTFVNGEKVKQSRLKEGDRILIGTSILKLVHQGAEGASVDEGTARLKLEEAAAAQAARTTNKASSMTGKIEEIPLPDLLQLFHTSKKNGVLVVQRSDQEGRIYLRQGRVYYAVIGENHNLGPQKSFNRIITWEEGDFELRPAENQEFMVELDSSTEALLMDALRQLDEIKRLQPSLPTADTALALASPLTPPLKELAPELLDVLQLVHNYGTLNAVMDHADADDVVTAEAVVQLLKRDYIRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB23</accession>
    <name>Q1DB23_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552006.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1905"/>
    <dbReference type="EnsemblBacteria" id="ABF88115">
        <property type="protein sequence ID" value="ABF88115"/>
        <property type="gene ID" value="MXAN_1905"/>
    </dbReference>
    <dbReference type="GeneID" id="41359320"/>
    <dbReference type="KEGG" id="mxa:MXAN_1905"/>
    <dbReference type="eggNOG" id="COG5293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456234_0_0_7"/>
    <dbReference type="OMA" id="FPRFVYH"/>
    <dbReference type="OrthoDB" id="1105801at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018760">
        <property type="entry name" value="DUF2326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10088">
        <property type="entry name" value="DUF2326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2326" evidence="2">
        <location>
            <begin position="455"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="597" mass="68276" checksum="CF0A7DB49A7636F6" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB28</accession>
    <name>Q1DB28_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552001.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87602">
        <property type="protein sequence ID" value="ABF87602"/>
        <property type="gene ID" value="MXAN_1900"/>
    </dbReference>
    <dbReference type="GeneID" id="41359316"/>
    <dbReference type="KEGG" id="mxa:MXAN_1900"/>
    <dbReference type="HOGENOM" id="CLU_2700914_0_0_7"/>
    <dbReference type="OrthoDB" id="639326at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="73" mass="8484" checksum="B1F32B35F6251749" modified="2006-07-11" version="1">MTPAVGAYLGNVLVRRLGGQWIPRKKLEESQVRVGKRVWLPFLRAYRYMQLCEALPEHAHTHSFARWNCTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB72</accession>
    <name>Q1DB72_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IPT/TIG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551957.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1855"/>
    <dbReference type="EnsemblBacteria" id="ABF90278">
        <property type="protein sequence ID" value="ABF90278"/>
        <property type="gene ID" value="MXAN_1855"/>
    </dbReference>
    <dbReference type="GeneID" id="41359271"/>
    <dbReference type="KEGG" id="mxa:MXAN_1855"/>
    <dbReference type="eggNOG" id="ENOG50319KV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_927210_0_0_7"/>
    <dbReference type="OMA" id="NRNRWLS"/>
    <dbReference type="OrthoDB" id="1064647at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="32061" checksum="FE0BADA262B48E1A" modified="2006-07-11" version="1">MAIPTLTSVTPSSGPTSGGDILRLAGTGFAARVAVSLGGLRAEVLSVRQQSGTSHVDVRTPPHAVALVDVELLNLSADGRPIPGEAALLPGAYRYLRPRVAKEADLTRLVRTLLRELKRQVVANVSASVSVDYDDTVADGLNVIAMASLPSVVLSGPTLRESRRYSTNVLHEDVVQGPSGSELVRRRPTYTVDLAFTLTVASERTAELFNLMAAVATFLNRNRWLSMARDAEDASRGTVRWEMDADGEVRTQLGSRDDVRAFTWGLLVRGFDVDEGLPLDIGKAVAGTHLETDSLSGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBG5</accession>
    <name>Q1DBG5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551867.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1758"/>
    <dbReference type="EnsemblBacteria" id="ABF92665">
        <property type="protein sequence ID" value="ABF92665"/>
        <property type="gene ID" value="MXAN_1758"/>
    </dbReference>
    <dbReference type="GeneID" id="41359187"/>
    <dbReference type="KEGG" id="mxa:MXAN_1758"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_7"/>
    <dbReference type="OMA" id="REFMSGA"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="36399" checksum="425478A8D0C4C5CB" modified="2006-07-11" version="1">MKGAAMRATVLHKPGDVRFEERAEPKILAPTDAIIRLSATCVCGSDLWPYRGVQAVTEPTPMGHEYCGIVEEVGSAVASVKPGQFVIGSFFASDNTCPHCKAGYQTSCQHREPVSGAQAPRMRVPLADGTLVVTAEVPPDALVPSLLAVSDVFGTGWFAADAANVNPGSTVVVVGDGAVGLLAVLSAKQMGAERIIAMSRHETRQALAREFGATDIVSVRGDEGVARIKELTRGIGADSVLECVGTQESMLQAIGAARPGGFVSYVGVPHGVSLDGEKLFFSHVHLHGGPAPVRRFMPQLIDLVWSRKVNPGKVFDLTLPLEKVAEGYRAMDERRAIKALLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBK6</accession>
    <name>Q1DBK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase orfA, IS3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1716"/>
    <dbReference type="EnsemblBacteria" id="ABF89070">
        <property type="protein sequence ID" value="ABF89070"/>
        <property type="gene ID" value="MXAN_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1716"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_7"/>
    <dbReference type="OMA" id="PHPPEFR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="116" mass="13122" checksum="455822474D55F845" modified="2006-07-11" version="1">MPKSRPPYPPEFRERVVELLKAGRSGKSLAREFGCTEQSIRNWKKQLEGSGRSAPSSNGESRPAPRASSAASDERAELERLRREVRVLREERDILKKAAAWFAQESVATPKRRTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBR8</accession>
    <name>Q1DBR8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_1653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551764.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1653"/>
    <dbReference type="EnsemblBacteria" id="ABF90445">
        <property type="protein sequence ID" value="ABF90445"/>
        <property type="gene ID" value="MXAN_1653"/>
    </dbReference>
    <dbReference type="GeneID" id="41359095"/>
    <dbReference type="KEGG" id="mxa:MXAN_1653"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_2_7"/>
    <dbReference type="OMA" id="ERTWPLH"/>
    <dbReference type="OrthoDB" id="797871at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF90445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="300" mass="32626" checksum="FD431033EF59DCE6" modified="2006-07-11" version="1">MNTATLGHAEVSLNGKGTGEPRASTASLVPPEVGRLRFDAARTLWLWGMLIPGVTVGLAAATPTTVVVSLLLTFATLCLGHSVGLHRGVIHRTYEAGPLTRGVLAYLFVLSGLGGPLSWARLHAVRDYWQNRPDCPPYFAYEHSMARDFGWNLHLRFEPADDRALARLPPDVLTDPWLCFLERTWPLHVLGLTGVVLAVLGPEAVALCVCARTAAGILGHWAVGYAAHVWGERRYALPGAAESGTNIWVLGVLSFGEGFHNNHHAFPGSARMGQKAHELDLGWWVIRGLCRLGLVRDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBX1</accession>
    <name>Q1DBX1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, classs I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551711.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1600"/>
    <dbReference type="EnsemblBacteria" id="ABF87178">
        <property type="protein sequence ID" value="ABF87178"/>
        <property type="gene ID" value="MXAN_1600"/>
    </dbReference>
    <dbReference type="GeneID" id="41359045"/>
    <dbReference type="KEGG" id="mxa:MXAN_1600"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_4_7"/>
    <dbReference type="OMA" id="KRDYNTI"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="42552" checksum="F11426D07FEDAB11" modified="2006-07-11" version="1">MEPLRTFFMEDYLEGSRFTARFNLGESGGRPVTVGELLLGSGVSAERAAEVFLSTPLNDSPNWGRADLRDAVAAMHPGATRDNVLITTGTSEALLLLFRQLRPRKVALAWPAFQLLYELPQRQGAEVVRLPVKWDANGVPSVDADLWLERLEREQPDTVIINNPHNPSGLVLTAELLSAVERWAERTGATVVGDEHYRFLSSETSVLGASVYRPGSRHFVTGSFIKCLGCPGLRIGWTVGDTAMLSRMQNEKNYTTHTVNPVTEWVAREVLRDLDSPALRRAREDWLRNRATLSAFLERSRGVYGVAPQGGLVTCIGLREARDDASAETLLKALSDVGVFVLPLSAMEAGSPDGAHPLERGHGFRLGLGIAPERFSEALDAIERATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC30</accession>
    <name>Q1DC30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF2/helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1541</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551652.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1541"/>
    <dbReference type="EnsemblBacteria" id="ABF91528">
        <property type="protein sequence ID" value="ABF91528"/>
        <property type="gene ID" value="MXAN_1541"/>
    </dbReference>
    <dbReference type="GeneID" id="41358985"/>
    <dbReference type="KEGG" id="mxa:MXAN_1541"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_7_7"/>
    <dbReference type="OMA" id="LAWRFVE"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="748"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1208" mass="133435" checksum="8D1FDC47F7C9E105" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC6</accession>
    <name>Q1DCC6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551556.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1440"/>
    <dbReference type="EnsemblBacteria" id="ABF92770">
        <property type="protein sequence ID" value="ABF92770"/>
        <property type="gene ID" value="MXAN_1440"/>
    </dbReference>
    <dbReference type="GeneID" id="41358886"/>
    <dbReference type="KEGG" id="mxa:MXAN_1440"/>
    <dbReference type="eggNOG" id="COG3816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121465_0_0_7"/>
    <dbReference type="OMA" id="WHTREDS"/>
    <dbReference type="OrthoDB" id="1518356at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010707">
        <property type="entry name" value="DUF1285"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06938">
        <property type="entry name" value="DUF1285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="173" mass="19416" checksum="F1CB87EACAAA7CA9" modified="2006-07-11" version="1">MRDVMQPPTGQPPPGKRWHTREDSGIRLDARMRWWHDDEPILHPKIIELFNASLVLDDADRYQLRIGNDWCFIQVEGAAYEVRTVDVTPDERVSVRLSDRTAEALDVASLHLDADGVLSCRVKQGRAQARLSRDAQYQLGQLLEEGPDGGLVLNVGQRKLAVPVKLDVLASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI2</accession>
    <name>Q1DCI2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551501.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1384"/>
    <dbReference type="EnsemblBacteria" id="ABF91855">
        <property type="protein sequence ID" value="ABF91855"/>
        <property type="gene ID" value="MXAN_1384"/>
    </dbReference>
    <dbReference type="GeneID" id="41358831"/>
    <dbReference type="KEGG" id="mxa:MXAN_1384"/>
    <dbReference type="HOGENOM" id="CLU_2789575_0_0_7"/>
    <dbReference type="OMA" id="FLKPSFG"/>
    <dbReference type="OrthoDB" id="2016857at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="68" mass="7024" checksum="B47366D7ECAB2DAA" modified="2006-07-11" version="1">MSTQAIPEKKALPGAAPTAAEVTVFLKPSFGITIQRNTLCVSVSAKARPVDTVTPSDPRAVDDSIGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCI6</accession>
    <name>Q1DCI6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_1380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551497.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93043">
        <property type="protein sequence ID" value="ABF93043"/>
        <property type="gene ID" value="MXAN_1380"/>
    </dbReference>
    <dbReference type="GeneID" id="41358827"/>
    <dbReference type="KEGG" id="mxa:MXAN_1380"/>
    <dbReference type="eggNOG" id="ENOG5032I1C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2410177_0_0_7"/>
    <dbReference type="OMA" id="WARFQRC"/>
    <dbReference type="OrthoDB" id="1822083at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="92" mass="10435" checksum="4C3C837737148C6A" modified="2006-07-11" version="1">MAYDGELVKMENGRWARFQRCQVYRPGVEDAGETMLLIAVELDERYQRQLDEAADSLAQYRYQGVPVQVRFDSGSQGITLQPEQTVSAPAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD07</accession>
    <name>Q1DD07_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551326.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1207"/>
    <dbReference type="EnsemblBacteria" id="ABF92981">
        <property type="protein sequence ID" value="ABF92981"/>
        <property type="gene ID" value="MXAN_1207"/>
    </dbReference>
    <dbReference type="GeneID" id="41364681"/>
    <dbReference type="KEGG" id="mxa:MXAN_1207"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565992_0_0_7"/>
    <dbReference type="OMA" id="GLQMVGY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="448" mass="47792" checksum="C980C6B43FE3D711" modified="2006-07-11" version="1">MTPSVDLPKHGPSVIAGVIQRLSVSQLKRHKLCPRAWFFQKVMRVPEPSTGAQQVGTEGHAQLEHFLVTGEDVLGTFARAGAHLLPTPGPDLLVEQPLNGEPPLMAGGIPFTGFIDLVDARRLASDGALRITDHKFTSNVATNAASAEQLADADTEPGLQMVGYGAWALSQVERFPGLRTLELEHLYYQTRGQRLAASVVATVPAEHVEREWQTKVEPQVEAMKEHAQAARASDVPANYGPPCGKYGGCPFMAKCLTGENKTMSLRDKLLNKASESTPLTVAAVERDAPEPPAVLPPDAPTPTPVQTAPEVAQATEQPAPKRRGRPRKAAESEQPTDAAPSPPSALRVLFVDCIPTTIDGPTPESLTSYVDTMHRKVAEAGGVDDVRFAGSDSALGFGKWRGALAMAARAELPAPGSYVALGVSQSELMQVIVEALEPAFDVVVRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD24</accession>
    <name>Q1DD24_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_1190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1190"/>
    <dbReference type="EnsemblBacteria" id="ABF89522">
        <property type="protein sequence ID" value="ABF89522"/>
        <property type="gene ID" value="MXAN_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1190"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683007_0_0_7"/>
    <dbReference type="OMA" id="IAAWQDV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="210"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="424" mass="45303" checksum="AE7E803904919B48" modified="2006-07-11" version="1">MNRPMHAAAPTEAPTHGDRVGLEHAADLPLPPPRFRRRLLAVMLLAGWVPLVLLGVLAQAALERVLSVSIAPVEGVLEEVASELARRELPQDSLNEARLNLAQAELARRALVRRVPAFITALILISGAALTVAAVLLGRALTRPVRTLTEGMWAYARGDLSVRLATPEPPRDELQFLLGQFNRMGQELLSQRERLKSAEQIAAWQDVARALAHELKNPLTAMKLSLARLNRTDASTPHDTTRITEAVALLQEEVDLLMRMTQSFSTFARLPAPRFQDVPLRPLLAEVCTLYAGTSPVPVELRPGAEATLRADPDGLRRLFGNLVKNATEASSASAAPVHVTLESPQPGTVCVTVADGGSGVPTVLEGPALTRGLFSTKPGGSGLGLPISQKIVHEHGGSLRLEPAPGGGTLARVELPLTPPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD36</accession>
    <name>Q1DD36_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551297.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1177"/>
    <dbReference type="EnsemblBacteria" id="ABF87062">
        <property type="protein sequence ID" value="ABF87062"/>
        <property type="gene ID" value="MXAN_1177"/>
    </dbReference>
    <dbReference type="GeneID" id="41358627"/>
    <dbReference type="KEGG" id="mxa:MXAN_1177"/>
    <dbReference type="eggNOG" id="ENOG5031DA6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871051_0_0_7"/>
    <dbReference type="OMA" id="VEGANTR"/>
    <dbReference type="OrthoDB" id="2044291at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="321" mass="31935" checksum="7E42322AA3B12D48" modified="2006-07-11" version="1">MAPPIRRNEPRPVPPPPVTARPTPPPPPPPPARAEARPGQSDRFEDAHNRVTQAATGLRSVSDAAVATQVRDAFGPRRFGPVNLPGGNGPVVEGANTRLARGAGAVSLAANVAQLPTGAVETFRDVRDALRNPTEANVREAVGTASGTLSTGLMAARDGLSLAGNVSNYRAATDAARTAFTAAAPDASRAAANRVATTAANTALEGASRQVVRRAAAEVAERGLEGAARTAGTAARAAVQGGGTAVARAAGRFTPGLNVAIAAADTVAAVNTITDPNASAGKKITAGVTALGSIAAATNIPVVSQVGAAVSTVSGFIGSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD61</accession>
    <name>Q1DD61_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551272.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1152"/>
    <dbReference type="EnsemblBacteria" id="ABF89176">
        <property type="protein sequence ID" value="ABF89176"/>
        <property type="gene ID" value="MXAN_1152"/>
    </dbReference>
    <dbReference type="GeneID" id="41358603"/>
    <dbReference type="KEGG" id="mxa:MXAN_1152"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_2_7"/>
    <dbReference type="OMA" id="RMSKMTD"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014290">
        <property type="entry name" value="SUF_FeS_clus_asmbl_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02944">
        <property type="entry name" value="suf_reg_Xantho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="17959" checksum="58419BBAD9AFEC92" modified="2006-07-11" version="1">MLRMSKMTDYGIVLMTELARAEGDTRTTRELAARTRVPLPSASKVLKSLLQAALVVSHRGANGGYGLARPAHELPLAELVTALEGPVALTECGVHTSGGAPCELESVCQVRGHWRLINDAIQEALGRLTLADLIAPAPRVPERLVGLGTPSRPAPSPAAGHPPPASATGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD77</accession>
    <name>Q1DD77_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551256.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1136"/>
    <dbReference type="EnsemblBacteria" id="ABF91984">
        <property type="protein sequence ID" value="ABF91984"/>
        <property type="gene ID" value="MXAN_1136"/>
    </dbReference>
    <dbReference type="GeneID" id="41358587"/>
    <dbReference type="KEGG" id="mxa:MXAN_1136"/>
    <dbReference type="eggNOG" id="COG4539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1625308_0_0_7"/>
    <dbReference type="OMA" id="IHYICVP"/>
    <dbReference type="OrthoDB" id="1934114at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="PTHR28026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="DUF962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="17901" checksum="3EAEEABFC2ABE3A5" modified="2006-07-11" version="1">MLKPHVVALFDEYYSSHQHPTNRLTHKIAIPLIVLHIVAMLDWVHLMAVPAIPGGSLTLGMVVLALAAVWYLRADVKLGIIVVLFMAACFPVGRMMPTWSVVVMAAFAWLVQLAGHSVWEKKSPSFLTNLVHALVGPLFFVAVLLGDYVLKPQQQAATTPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDP9</accession>
    <name>Q1DDP9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86651">
        <property type="protein sequence ID" value="ABF86651"/>
        <property type="gene ID" value="MXAN_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0963"/>
    <dbReference type="HOGENOM" id="CLU_3357237_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="36" mass="4188" checksum="5CC6B13B2216FA57" modified="2006-07-11" version="1">MKTPRSQQAPGRFSFSPADSGLLLQRRPERFRIISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEN1</accession>
    <name>Q1DEN1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550755.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0624"/>
    <dbReference type="EnsemblBacteria" id="ABF91245">
        <property type="protein sequence ID" value="ABF91245"/>
        <property type="gene ID" value="MXAN_0624"/>
    </dbReference>
    <dbReference type="GeneID" id="41358102"/>
    <dbReference type="KEGG" id="mxa:MXAN_0624"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370917_0_0_7"/>
    <dbReference type="OMA" id="SNVVERW"/>
    <dbReference type="OrthoDB" id="1452465at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="60"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="21692" checksum="F9682A3037C3BC67" modified="2006-07-11" version="1">MTDPGSPSPLTVVPGGDGGFLSRLPTVLQPHRSLLTYYLVSALLAGPGFPILGLIRYFKYQTLRYTLDDEGITVRWGILFRREVSLTYARIQDIHLSSNLVERWLGLARIQIQTASGNSQAEITIEGVPAHEAMRDFLYSKMRGSRERAVPTQESARAMPAGDHDALAATLREIAEEVRALRLSLNSGATREKQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEQ6</accession>
    <name>Q1DEQ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550730.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90819">
        <property type="protein sequence ID" value="ABF90819"/>
        <property type="gene ID" value="MXAN_0599"/>
    </dbReference>
    <dbReference type="GeneID" id="41358077"/>
    <dbReference type="KEGG" id="mxa:MXAN_0599"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011736_6_0_7"/>
    <dbReference type="OMA" id="GAHRIFD"/>
    <dbReference type="OrthoDB" id="1779628at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="14"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="432"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="560" mass="63968" checksum="CF7E6A6F512CD2C9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEZ6</accession>
    <name>Q1DEZ6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0508"/>
    <dbReference type="EnsemblBacteria" id="ABF92994">
        <property type="protein sequence ID" value="ABF92994"/>
        <property type="gene ID" value="MXAN_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0508"/>
    <dbReference type="eggNOG" id="COG5031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085689_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="283" mass="30543" checksum="AEEEDDFBFB561D5E" modified="2006-07-11" version="1">MGHVPMAGLAVPSWELALGAAVHAVAHTASRLRPRHTRGPEHEHRSPRASPGLMPLLGRDVQHGGLRVRLLANPRGSCARCEGVHAMETMATALRRYFDESGFGEDGGYASDWVDFKLGPLPFPLPNTEARKRAVRFHDLHHVLTGYRTDLTGEFEISAWEIGAGCGDFHAAWVLNLSGMTGGLLTAPVRTWRAFVRGLDEQSTYGRDYEALLERNVEDLRAELGIGAGPHRAGLGAALRFAAAITAGAVVGSLMMLVLVSPITLALWWRGRRAKAQALAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFE3</accession>
    <name>Q1DFE3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pilus biogenesis operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0356"/>
    <dbReference type="EnsemblBacteria" id="ABF90474">
        <property type="protein sequence ID" value="ABF90474"/>
        <property type="gene ID" value="MXAN_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0356"/>
    <dbReference type="HOGENOM" id="CLU_830831_0_0_7"/>
    <dbReference type="OMA" id="FLSLKVQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="37247" checksum="2D0D7EBB5C60DF61" modified="2006-07-11" version="1">MHRATGEGRDMELSPSRRTQRGQAMVEMAIGSLVFITILLFVIHFAEVSFLSVKVTEAAHSALLEAPGHKLHEWPNDSSPSSAAAERAGQDAAMRYRDFDSRTTTNSAGVITLALTRTDGMQVSCTQGGPTFDPHPVFTSVAYRDGGGISCTAQADLTAFRIPQRVAQRESGGFFQAEHYRMLPIRVCAMGRAQGGNCTGRLTSMLDDWGLTGSGESGSCPIIPDIPAPCPLNLPYWGMASSVYGVSLMVNAFGPDFSASRLAQTVVGGLPLPFFFGAENMFWMSAVGEEAFFGQPLPADSMGGLATMGFKGWPTSPGLLPPGLNWQAIPYPVSYGRRDSCFLGNECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG23</accession>
    <name>Q1DG23_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550264.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0117"/>
    <dbReference type="EnsemblBacteria" id="ABF90109">
        <property type="protein sequence ID" value="ABF90109"/>
        <property type="gene ID" value="MXAN_0117"/>
    </dbReference>
    <dbReference type="GeneID" id="41357622"/>
    <dbReference type="KEGG" id="mxa:MXAN_0117"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009368_0_0_7"/>
    <dbReference type="OMA" id="QQSQVCA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="780"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="924" mass="100625" checksum="AD3B09F84C898DB4" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG65</accession>
    <name>Q1DG65_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-like repeat/amidohydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0075"/>
    <dbReference type="EnsemblBacteria" id="ABF92182">
        <property type="protein sequence ID" value="ABF92182"/>
        <property type="gene ID" value="MXAN_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0075"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003547_0_0_7"/>
    <dbReference type="OMA" id="IIPQQNW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="680"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116080" checksum="2653178568009D31" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG68</accession>
    <name>Q1DG68_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550219.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0072"/>
    <dbReference type="EnsemblBacteria" id="ABF89765">
        <property type="protein sequence ID" value="ABF89765"/>
        <property type="gene ID" value="MXAN_0072"/>
    </dbReference>
    <dbReference type="GeneID" id="41357579"/>
    <dbReference type="KEGG" id="mxa:MXAN_0072"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_9_0_7"/>
    <dbReference type="OMA" id="NVRVEAW"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="154" mass="17128" checksum="DD48FE979A07C6DD" modified="2006-07-11" version="1">MTTMSESTTPPLAELVRQVRKTREYKRLTDAIPYTRFMGIGVENLAGEMLCRMAFNPRNIGNSLIPALHGGTLGALLESAAVFELLLQTNTERVPKVISLTVDFLRSGKPQDTFAKAFVTRQGRRVANVRVDAWQDDRTRPIASAHALFLLSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGB2</accession>
    <name>Q1DGB2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0028"/>
    <dbReference type="EnsemblBacteria" id="ABF92882">
        <property type="protein sequence ID" value="ABF92882"/>
        <property type="gene ID" value="MXAN_0028"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0028"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089171_0_0_7"/>
    <dbReference type="OMA" id="SCRRYHC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF92882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="28197" checksum="69A26001B41080C5" modified="2006-07-11" version="1">MRDLRILTGSVSTNEPRVTCSPGQDWMSDFSSVTRTVVSLSDGMCARIPSGPCAPRFFGGEVVWHGHRGGERSYACSLRWNQFRQRVRGRTMPRNTLCLRCGMCCDGTLFTHVSLQLEEALALQRRGLPVGSRTDGSLALMQHCSALDERTCTIYEDRPASCRRYHCQLSSALAEKEVSLDEALEVVDEAHARVAAVARTLAPASEGAPRSVLQRARRANLLDHGGPLSATDLATYEHAEAYLDTHFRGRFGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DGC3</accession>
    <name>Q1DGC3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GSH synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <shortName evidence="10">GSHase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gshB</name>
        <name evidence="13" type="ORF">MXAN_0017</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550166.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0017"/>
    <dbReference type="EnsemblBacteria" id="ABF90737">
        <property type="protein sequence ID" value="ABF90737"/>
        <property type="gene ID" value="MXAN_0017"/>
    </dbReference>
    <dbReference type="GeneID" id="41357524"/>
    <dbReference type="KEGG" id="mxa:MXAN_0017"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068239_0_0_7"/>
    <dbReference type="OMA" id="WMRKDPP"/>
    <dbReference type="OrthoDB" id="878336at2"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00162">
        <property type="entry name" value="GSH_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006284">
        <property type="entry name" value="Glut_synth_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004218">
        <property type="entry name" value="GSHS_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004215">
        <property type="entry name" value="GSHS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF4">
        <property type="entry name" value="PTHR21621:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02955">
        <property type="entry name" value="GSH-S_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02951">
        <property type="entry name" value="GSH-S_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01380">
        <property type="entry name" value="glut_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="128"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABF90737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="35555" checksum="507694F1AC4036A2" modified="2006-07-11" version="1">MAPLTIGFLMDPLETVRVDHDSTFALMLEAQKRGHQVRYFEQGWLRFNGTCAEARMRHVTVRRELGRHFDILDEAPRPVSSLDVLFMRKDPPVDAEFLHATQLVELCGTGRPPVFINEPAGLRDANEKLFSLRYPDLMPDTRVTSELPVLLDFIARNAAGTILKPVDGFAGKGILFLSATDRNARSAVDMLTRGGREAVMAQAYIPESRQGDKRILLVDGEPVGGVLRVPSDDDHRGNMAAGGVPQKAVLTPRDLEICERLKPELVKRGLRLVGIDVLGTYLTEVNVTSPTGLVEANQLDDVCVEAKVLDVAERLVAERAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-05-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>P25970</accession>
    <accession>Q1CZX7</accession>
    <name>Y5909_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized oxidoreductase MXAN_5909</fullName>
            <ecNumber>1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">MXAN_5909</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="819" last="824">
            <title>The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family.</title>
            <authorList>
                <person name="Kimsey H.H."/>
                <person name="Kaiser D."/>
            </authorList>
            <dbReference type="PubMed" id="1730672"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL" id="M79325"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.-.-.-"/>
    <dbReference type="EMBL" id="M79325">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555860.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P25970"/>
    <dbReference type="SMR" id="P25970"/>
    <dbReference type="STRING" id="246197.MXAN_5909"/>
    <dbReference type="EnsemblBacteria" id="ABF86550">
        <property type="protein sequence ID" value="ABF86550"/>
        <property type="gene ID" value="MXAN_5909"/>
    </dbReference>
    <dbReference type="GeneID" id="41363147"/>
    <dbReference type="KEGG" id="mxa:MXAN_5909"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_7"/>
    <dbReference type="OMA" id="AEMVMEV"/>
    <dbReference type="OrthoDB" id="1186478at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000054891" description="Uncharacterized oxidoreductase MXAN_5909">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1." evidence="3" ref="1">
        <original>LR</original>
        <variation>A</variation>
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1." evidence="3" ref="1">
        <original>QAAGVTVEPVEL</original>
        <variation>PGGRRHRGARGV</variation>
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1." evidence="3" ref="1">
        <original>AGHAA</original>
        <variation>PATR</variation>
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="253" mass="26969" checksum="F47D8F1834EC7C71" modified="2006-09-19" version="2">MAEMSYRTALVTGASSGLGRGLALWLARRGVRVFAAGRRLPQLQALRDEAQAAGVTVEPVELDVTKADATLERIRALDAEAGGLDLVVANAGVGGTTNAKRLPWERVRGIIDTNVTGAAATLSAVLPQMVERKRGHLVGVSSLAGFRGLAGHAAYSASKAFLSTFMESLRVDLRGTGVRVTCIYPGFVKSELTATNNFPMPFLMETHDAVELMGKGIVRGDAEVSFPWQLAVPTRMAKVLPNPLFDAAARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVK4</accession>
    <name>Q1CVK4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Voltage-gated chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_7465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557372.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7465"/>
    <dbReference type="EnsemblBacteria" id="ABF92339">
        <property type="protein sequence ID" value="ABF92339"/>
        <property type="gene ID" value="MXAN_7465"/>
    </dbReference>
    <dbReference type="GeneID" id="41364611"/>
    <dbReference type="KEGG" id="mxa:MXAN_7465"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_5_1_7"/>
    <dbReference type="OMA" id="DIVTQPG"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="536"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="588" mass="61544" checksum="A8E2D5D25D346A3B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVU9</accession>
    <name>Q1CVU9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7367"/>
    <dbReference type="EnsemblBacteria" id="ABF92267">
        <property type="protein sequence ID" value="ABF92267"/>
        <property type="gene ID" value="MXAN_7367"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7367"/>
    <dbReference type="HOGENOM" id="CLU_1004090_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="277" mass="29523" checksum="B94672C87DDA528D" modified="2006-07-11" version="1">MSPPYPGSGGLSRQRGCVHRVTRILEPPGVNEQASSWRLTVERLPGGPLRPPVRPSARSPSAPDPPRCAGALPFVVLAVPWAPLRVGALNNRSGQGVAIQRTRQPSIGDAAPSGEDAGPGSMTQMEMRMRKLALLLFVGLWLGCRADGTDSTEGTLPLHPQETYTYPGCANEDYNCPRLKTVHCALESLRTERDSCQQDSDCVAVSVNGRCTGYGECPPAMVNTASRAEFATRAAEEVLRYCTESPICASTGQCAYPSFVPRCKQGHCVAEPGDAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW10</accession>
    <name>Q1CW10_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86205">
        <property type="protein sequence ID" value="ABF86205"/>
        <property type="gene ID" value="MXAN_7300"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7300"/>
    <dbReference type="HOGENOM" id="CLU_2207189_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="107" mass="10910" checksum="32026F6A2F3442D9" modified="2006-07-11" version="1">MAGEAWARGQKRRSEDQGKGFQKGVTTSSPSSGNQGPVSPPAESTWKSCAGMKPCPSSATLFPAALAATSSTSTACPGLPPSTKKSPGRTSSREGRPLRDSSECVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CW93</accession>
    <name>Q1CW93_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7217"/>
    <dbReference type="EnsemblBacteria" id="ABF86602">
        <property type="protein sequence ID" value="ABF86602"/>
        <property type="gene ID" value="MXAN_7217"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7217"/>
    <dbReference type="HOGENOM" id="CLU_386766_0_0_7"/>
    <dbReference type="OMA" id="IDCATHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="646" mass="71828" checksum="0E9DA8A4C68BA3F7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWA3</accession>
    <name>Q1CWA3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557126.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87118">
        <property type="protein sequence ID" value="ABF87118"/>
        <property type="gene ID" value="MXAN_7207"/>
    </dbReference>
    <dbReference type="GeneID" id="41364377"/>
    <dbReference type="KEGG" id="mxa:MXAN_7207"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193832_0_0_7"/>
    <dbReference type="OMA" id="CCHGTRE"/>
    <dbReference type="OrthoDB" id="1482681at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="1">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="232" mass="25060" checksum="D2BE678CA886D163" modified="2006-07-11" version="1">MLRAPKRGWMSNGSLFATDQVTTQARYQWHLWVADVLDLGTSVLVGWGALRALEQDRTPLSMPLAMALAWLTASAVGGLTGRTFWRQVAGVKLVHAEHTPGLLRGLARAFTTPLDLLLNGVLMRRPLDTLLGLHAEPVAPGAGPRLKGVALQLPWLAVLAGAVWLLVTPTKAEMLQYLGRTLTGWHCCHGTREVTWQCRTSLDRAVRNARGGDAEVKALVADCPVAGARLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWB6</accession>
    <name>Q1CWB6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557113.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7194"/>
    <dbReference type="EnsemblBacteria" id="ABF88217">
        <property type="protein sequence ID" value="ABF88217"/>
        <property type="gene ID" value="MXAN_7194"/>
    </dbReference>
    <dbReference type="GeneID" id="41364367"/>
    <dbReference type="KEGG" id="mxa:MXAN_7194"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_7"/>
    <dbReference type="OMA" id="NEQVIVI"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="35961" checksum="96EF1C8F1BF790F1" modified="2006-07-11" version="1">MKRAWKNQVVVVTGASSGIGRATALALANKGAHVVLAARREEPLEDLARECRGLGVQAHVVPTDVSDVAAVQHLADEARNVFGHFDAWINNAGVYLMGRLEETPDDAFRQVMETNFFGTVSGARAAVAQFRRQGYGTLVNVSSTFGAVAAPYVSAYVASKHAVRGFSASVRQELLGTGIDVCTVLPAAIDTPLWQHTANYTGWRIRPVEPVYTPERVARAILRVLRSPKHEVFVGPAARSFAAMHGLLPRTFERTMNGVTEAHHFEKERQGHTSGTLFRPMAEGTGTSGGHHAAGKQWLRRLLVAGGVAAAAFSLGKKREARGLKARFAHALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWE2</accession>
    <name>Q1CWE2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_7168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88270">
        <property type="protein sequence ID" value="ABF88270"/>
        <property type="gene ID" value="MXAN_7168"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_7168"/>
    <dbReference type="HOGENOM" id="CLU_760374_0_0_7"/>
    <dbReference type="OMA" id="CTWIRHE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="411" mass="44686" checksum="A02A9BD0FACAC4E2" modified="2006-07-11" version="1">MKREPTMEASDEVQMTPVRLSGTPGVASSEAQPSAMVEGRFPLERNMSRHLGPAVILGSTLLLGSACKKSEDPAPEPSATPPPAPTEPAPGYTLSFLEAASPSGCTWIRHESSGTRKPLATVDAVCERLKLAWGPRGRQGLVMDRGNGELPPRAWQVDFESGQSTRLLLPELGHTDTLGFDEAGHVVALVSQLEDLPRKMESGSEYFLFDGKRFLLPEAEGSPGLAHAYRHEAGQWKHLETVATLYEMDGALGTEALATASRLTSSTFSQDADRLSESELEEGNEDAARLDAVVKDRGHTAYGMWVSMETHQGPLYSWEATGELPTLMLPLRWEVNDRLVEPEQLALAPTSTVALRMRGRLLLVSAEQAARVYDAKTKKRIAALENVHGTRFWPQQRTVTAAAPASTVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWH5</accession>
    <name>Q1CWH5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_7135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557054.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7135"/>
    <dbReference type="EnsemblBacteria" id="ABF88837">
        <property type="protein sequence ID" value="ABF88837"/>
        <property type="gene ID" value="MXAN_7135"/>
    </dbReference>
    <dbReference type="GeneID" id="41364309"/>
    <dbReference type="KEGG" id="mxa:MXAN_7135"/>
    <dbReference type="eggNOG" id="ENOG50309JR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120443_1_0_7"/>
    <dbReference type="OMA" id="NDYYIAN"/>
    <dbReference type="OrthoDB" id="1933506at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="199" mass="22560" checksum="B06475A51E88F5A1" modified="2006-07-11" version="1">MNTVCHSYFILSTVREPKNCVIHEEPTSIRDMSWRMSRGLPVDERFPSDVVLQVDGGTKGITLPDFVSNTVQLAIVSRKFKQTLDEHAAANIEYLPISIANHKGRVSGNDYYIANLLDHHDCIDMERSEVEQLGMEPEFLSGLFRLHITEDRVPHEAKLFRLKSMPSAILIRDDLRATVDVAGLTGVKYIGMGERCRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWM4</accession>
    <name>Q1CWM4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_7086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557005.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7086"/>
    <dbReference type="EnsemblBacteria" id="ABF90286">
        <property type="protein sequence ID" value="ABF90286"/>
        <property type="gene ID" value="MXAN_7086"/>
    </dbReference>
    <dbReference type="GeneID" id="41364261"/>
    <dbReference type="KEGG" id="mxa:MXAN_7086"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_6_0_7"/>
    <dbReference type="OMA" id="ARHCLTC"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="101" mass="11272" checksum="1FA426D08AC9FD1A" modified="2006-07-11" version="1">MGPEWPGWPQWETNMELLAREAQEALRQRSHRLRARASLGVGGLSFTQAEAQELRDIEEALTRIAHGEFGRCARCGGAIGRHRLRAVPEARHCLTCAALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX77</accession>
    <name>Q1CX77_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556804.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6881"/>
    <dbReference type="EnsemblBacteria" id="ABF90752">
        <property type="protein sequence ID" value="ABF90752"/>
        <property type="gene ID" value="MXAN_6881"/>
    </dbReference>
    <dbReference type="GeneID" id="41364068"/>
    <dbReference type="KEGG" id="mxa:MXAN_6881"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100234_0_0_7"/>
    <dbReference type="OMA" id="PPFVMYY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="25967" checksum="6F7B450ABFC3B4A6" modified="2006-07-11" version="1">MFHRKGPTLRELAAQALTSVEHGYDLLAPKFEYTPFRTPDAVLEAAIAQLGAPGSVGSALDVCCGTGAAMRFLRPLARERVVGFDLSQGMLDEARQQLAQAPGTAALEFIQGDALALPFDGAFDVVTSFGAFGHILEEDEPRLVKGIARALRPGGRFLFVTAHPPSKLRPGYWMAKGFNAAMRARNALWNPPFVMYYLTFLVPRARALLETEGFTVEVRDGLMPEPFSVLSTVIATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CX95</accession>
    <name>Q1CX95_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport protein, ExbD/TolR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_6861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556786.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6861"/>
    <dbReference type="EnsemblBacteria" id="ABF88330">
        <property type="protein sequence ID" value="ABF88330"/>
        <property type="gene ID" value="MXAN_6861"/>
    </dbReference>
    <dbReference type="GeneID" id="41364050"/>
    <dbReference type="KEGG" id="mxa:MXAN_6861"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137878_0_0_7"/>
    <dbReference type="OMA" id="AVWTQIG"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF88330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="162" mass="17388" checksum="BDA38AC998826A84" modified="2006-07-11" version="1">MAGGMDTGGGKGGKKSLDTSINLTAFIDLMAVTISFLILTAVWTQIGRLQVSQAGGPSTEEEQQQEEQTKTVQLNLLITPTELRLTADQSAFDPIPLTKDAKGKTDLTKLVARFKELKAQLPDQSAITLQPEDKVRYEDLVRIIDECIGAGLPQVSVSAAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXR0</accession>
    <name>Q1CXR0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein DifA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">difA</name>
        <name evidence="7" type="ORF">MXAN_6696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1CXR0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6696"/>
    <dbReference type="EnsemblBacteria" id="ABF91646">
        <property type="protein sequence ID" value="ABF91646"/>
        <property type="gene ID" value="MXAN_6696"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6696"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_7"/>
    <dbReference type="OMA" id="AFGEKTQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="125"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="413" mass="43522" checksum="D4064E613C48221A" modified="2006-07-11" version="1">MGLALTGWMYASDGLINFVFPALSAGGKDAVRIGVAIIITGAAAALLPSWLARVTRVKVLSRSAYEISQGDLSKPVAAEGGSKRDEIDELTGAITRMQENLRELVGKIQETAKSVADTAIDLQRSAENVNGSTEEVGSSMEKIAGGAESQSQLVSKASKVITEMAGSIQRTTASAEDAARTTAETSSAAEDGSKAARLAGDKVKKVFNRIESASQQVFAFGEKTQEISKIVDAITQVAQQTNLLALNATIEAARAGEYGRGFAVVADEVRKLAESAGRSAEQISKLARDISGQSTSVVSAMKEGIAELAEGREDLTNIVRSMGAITDTIRKGSEKVHLISESAREQLKGSEEMVTAIEEIKLVARNNASSTEAIQAVIQEQTAAVSRMTSLASELTNLSVELQSVVRSFRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY33</accession>
    <name>Q1CY33_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferrichrome ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556498.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6568"/>
    <dbReference type="EnsemblBacteria" id="ABF90478">
        <property type="protein sequence ID" value="ABF90478"/>
        <property type="gene ID" value="MXAN_6568"/>
    </dbReference>
    <dbReference type="GeneID" id="41363773"/>
    <dbReference type="KEGG" id="mxa:MXAN_6568"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021206_0_0_7"/>
    <dbReference type="OMA" id="WIAEYPI"/>
    <dbReference type="OrthoDB" id="252974at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="745" mass="79051" checksum="F47656FF5FF01398" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY56</accession>
    <name>Q1CY56_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_6545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6545"/>
    <dbReference type="EnsemblBacteria" id="ABF89926">
        <property type="protein sequence ID" value="ABF89926"/>
        <property type="gene ID" value="MXAN_6545"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6545"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_7"/>
    <dbReference type="OMA" id="LAMEWIQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="392" mass="42129" checksum="214186DE3B047B6D" modified="2006-07-11" version="1">MDNEDSSFGKYRLVQQLATGGMAQLYLASIDGPDGFSKSCVIKRVLPEYASLESFSRMFADEAKVAALLTHPNIVQVFDFGRVDGQYYLAMEWIQGHSLDRLLRQALRSGRVVGTRVAVDVGLAVADALAYAHAKTLPDGTPLMLVHRDVTPGNVLVSRDGIIKLADFGIVKSAVNAERTVAGVVKGKYPYMSPEQITSQELDHRSDLYSLGIVLYEAATGRRLFKRDTLEATIMAASQANVPPPSEGTPDFPAELERIILRLLQKAPSARYQSARELRDDLERFRAAQQWASGTHEMAALVAELFPPSITGQPPTALPASSTSHGSNSATGRTPPPSAEPERELSSTSAATRAHGAVEVPLDTSAQGFPWGIALAAGCAALGTALFWLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY69</accession>
    <name>Q1CY69_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system, mannose/fructose/sorbose family, IID component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6532"/>
    <dbReference type="TCDB" id="4.A.6.1.12">
        <property type="family name" value="the pts mannose-fructose-sorbose (man) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87348">
        <property type="protein sequence ID" value="ABF87348"/>
        <property type="gene ID" value="MXAN_6532"/>
    </dbReference>
    <dbReference type="GeneID" id="41363739"/>
    <dbReference type="KEGG" id="mxa:MXAN_6532"/>
    <dbReference type="eggNOG" id="COG3716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088367_0_0_7"/>
    <dbReference type="OMA" id="QASWNPK"/>
    <dbReference type="OrthoDB" id="1632067at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="26809" checksum="2568A710F742471A" modified="2006-07-11" version="1">MSAPPAALPFGVLLRVFLRSLFLQASWNPKGMQNLGLAYAVYPALEALYPQGPAREEAVRRHLVFFNTHPYVAAAIVGGVINHEERIARGEETPDKVVAFKAALMGPLAALGDGFFWLSLKPATGAVSAALVPLLGVWAVPLFLVLYNLVHLLLRVRLYWLGLTLGDRLVEAVARANLPARGARLRAVAAASAGGVAAWLAVSFGANAGGLYAPLLAAGCLALGVASYVLVSRRVPNYVVLYVAAGLACVAGAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CY94</accession>
    <name>Q1CY94_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_6506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6506"/>
    <dbReference type="EnsemblBacteria" id="ABF92689">
        <property type="protein sequence ID" value="ABF92689"/>
        <property type="gene ID" value="MXAN_6506"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6506"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_13_0_7"/>
    <dbReference type="OMA" id="EAPHDIK"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="444"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="580" mass="61715" checksum="CD3670BED27CDE69" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYB0</accession>
    <name>Q1CYB0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation-transporting ATPase, E1-E2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556421.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6491"/>
    <dbReference type="EnsemblBacteria" id="ABF88701">
        <property type="protein sequence ID" value="ABF88701"/>
        <property type="gene ID" value="MXAN_6491"/>
    </dbReference>
    <dbReference type="GeneID" id="41363698"/>
    <dbReference type="KEGG" id="mxa:MXAN_6491"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_7"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="941" mass="99557" checksum="C2F0370D70769B38" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYE6</accession>
    <name>Q1CYE6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative arginine N-succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556385.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6454"/>
    <dbReference type="EnsemblBacteria" id="ABF88144">
        <property type="protein sequence ID" value="ABF88144"/>
        <property type="gene ID" value="MXAN_6454"/>
    </dbReference>
    <dbReference type="GeneID" id="41363660"/>
    <dbReference type="KEGG" id="mxa:MXAN_6454"/>
    <dbReference type="eggNOG" id="COG3138">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057655_0_0_7"/>
    <dbReference type="OMA" id="PEENRSW"/>
    <dbReference type="OrthoDB" id="972674at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008791">
        <property type="term" value="F:arginine N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007041">
        <property type="entry name" value="Arg_succinylTrfase_AstA/AruG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04958">
        <property type="entry name" value="AstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="341" mass="38609" checksum="07234520D5093993" modified="2006-07-11" version="1">MLVLRDVQKTDLPGLKRLAAVLNTVNLPNNEETLSAIVDTSVKSFAGKVKNPFEREYLFVLEDVRNSLIIGTSMIIAQHGTYEAPHIYYEVSEREHYSASLSRHLRHKVLSIAYNYEGPTEVGGLVVDPPYRATPDKPGKQLSYGRFLFIAMHRRLFRPRVLAELLPPLLPDGRSLLWEACGKKFTGLTYQEADRLSRQNKEFIKELFPASDIYASLFPARVQKVLGEVGPQTRGVQRMLERIGFKYMERIDPFDGGPHFEADTADISLVRKFRTLKVAEEDFDLEGDDVLVAAENDSGRNRFRAVRCQARLENTQAFLPARAKEVLDIQAGAKVSIIPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYI9</accession>
    <name>Q1CYI9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_6410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556342.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6410"/>
    <dbReference type="EnsemblBacteria" id="ABF88843">
        <property type="protein sequence ID" value="ABF88843"/>
        <property type="gene ID" value="MXAN_6410"/>
    </dbReference>
    <dbReference type="GeneID" id="41363620"/>
    <dbReference type="KEGG" id="mxa:MXAN_6410"/>
    <dbReference type="eggNOG" id="COG5267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026001_0_1_7"/>
    <dbReference type="OMA" id="MANQHAD"/>
    <dbReference type="OrthoDB" id="637794at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="574" mass="63230" checksum="95B6D3CB163F7848" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYV0</accession>
    <name>Q1CYV0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556231.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6298"/>
    <dbReference type="EnsemblBacteria" id="ABF88969">
        <property type="protein sequence ID" value="ABF88969"/>
        <property type="gene ID" value="MXAN_6298"/>
    </dbReference>
    <dbReference type="GeneID" id="41363514"/>
    <dbReference type="KEGG" id="mxa:MXAN_6298"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_7"/>
    <dbReference type="OMA" id="LWSKVAQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="289"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="500" mass="55587" checksum="7D98790EF99702A0" modified="2006-07-11" version="1">MLAQPAPQPELNRRLAKLTSILDVAKAMSAERDLDLLLPLILFEATKVVEADRCSLFILDRERNELWSKVAQGSKSEIRLPVGSGVAGQVAQTGAVINIPDAYADARFNRSFDVSSGYQTKTILCVPMRDAGGEVTGVIQALNKLDGASFNAEDEELLLALGAQAAGAIENALLHEDINRLFEGFVSASVVAIESRDPTTAGHSGRVADLTVAMAQALEHLSTGPYAHTRFSAGEIQELRYASLLHDFGKVGVREPVLVKAEKLYPHELEGLRARFQLARKDLQLQSYRRRLEAVKIRGQANLAEIEAEEEERLARESWQLDEVLEFILSCNRPTVLAQGNFERLHELGALRFLDAHDKAQPLLLPGEIQSLSIARGTLSPEERREIESHVEHTYRFLSQIPWTRTLRRVPEIAYAHHEKLDGTGYPRAEKDIPVQSRMMSICDIYDALTASDRPYKKAVPHTLALDILRRESDAGQLDPALYTVFIEADIPRKVLQGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZE5</accession>
    <name>Q1CZE5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6093"/>
    <dbReference type="EnsemblBacteria" id="ABF86130">
        <property type="protein sequence ID" value="ABF86130"/>
        <property type="gene ID" value="MXAN_6093"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6093"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873838_0_0_7"/>
    <dbReference type="OMA" id="CHCESHR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="367" mass="40724" checksum="6B8FB1490FF13663" modified="2006-07-11" version="1">MASSTWDRPTFSSTSGSPTPCACEAEGRQASRALQGCCEASRARLPCPAMHLVVANEAQKAERDRHTYTAWGSPLTVEQFLEREQRLRAHPWSRDTMRTWLLCDDAGRVLTSCETFRTPSYLRGPDCQTTRGDSFVIASVYTEPALRGHGHATRLMDQVAAELERTEPDAQAAVLYSDVGARIYRRSGYLEVPAWDWHLPVGNGPLIRKVDALLEDADVPSALERMRRPEVPFYLWPGASQVDWHLERERIYAELLRRPRPRACGAVVGASTALWAMMARQGELVVLMLDARSEDDAAALLEAAGAQAHKAGLSKVVLWEEPGTMPWVARLPEASREARDGSLPMVRPLREGLPTAADIPFARALWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZU7</accession>
    <name>Q1CZU7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter, drug/metabolite exporter (DME) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555890.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5939"/>
    <dbReference type="EnsemblBacteria" id="ABF86323">
        <property type="protein sequence ID" value="ABF86323"/>
        <property type="gene ID" value="MXAN_5939"/>
    </dbReference>
    <dbReference type="GeneID" id="41363178"/>
    <dbReference type="KEGG" id="mxa:MXAN_5939"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_2_7"/>
    <dbReference type="OMA" id="WIFLGEV"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="165"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="325" mass="34204" checksum="4547A0026B3A53B0" modified="2006-07-11" version="1">MGAPSARPLTSTSPQSLGPVYAGLMLQVLISAGTYLAGKRAMSELAPLTVVLWRFVLSGSVFMLLLCFLPGPRLPPRNEWGRVLMLGLLAGPVNQVFFFYGLSQSTAAHAALLYALTPLGVYLLSLGRGHERASFRAMGGIVTAFAGVVVLLLGRGLADASGSLMGDLLILGAVMSWVVYTTEGKPFVAIHGPIRATSWSMVASTLMMMLMAPFFAKPEAVLAASSAARYSIVYLGLLTSVVAYLLWYFALSRVPASKVAVFSNLQPAATALAAWVILDEALHWEIAVGGVLVLLGVRLTQAAHVRPPAVAPAAPERPPVSSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZX9</accession>
    <name>Q1CZX9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting protein RppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rppA</name>
        <name evidence="7" type="ORF">MXAN_5907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555858.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5907"/>
    <dbReference type="EnsemblBacteria" id="ABF91268">
        <property type="protein sequence ID" value="ABF91268"/>
        <property type="gene ID" value="MXAN_5907"/>
    </dbReference>
    <dbReference type="GeneID" id="41363145"/>
    <dbReference type="KEGG" id="mxa:MXAN_5907"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_99_0_7"/>
    <dbReference type="OMA" id="SVMEMDS"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
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            <end position="232"/>
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            <end position="278"/>
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            <end position="603"/>
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            <end position="717"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50885"/>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
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                <person name="Madupu R."/>
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                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="52"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF91432.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
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</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D094</accession>
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        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
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                <person name="Blanchard M."/>
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                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555743.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5792"/>
    <dbReference type="EnsemblBacteria" id="ABF90970">
        <property type="protein sequence ID" value="ABF90970"/>
        <property type="gene ID" value="MXAN_5792"/>
    </dbReference>
    <dbReference type="GeneID" id="41363035"/>
    <dbReference type="KEGG" id="mxa:MXAN_5792"/>
    <dbReference type="HOGENOM" id="CLU_1853058_0_0_7"/>
    <dbReference type="OMA" id="LFFANVP"/>
    <dbReference type="OrthoDB" id="1591981at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="139" mass="15076" checksum="FC3D58097C3B17D2" modified="2006-07-11" version="1">MRLSATMPWLVALVLLLSLGGCNRPRFGTPQDAYTSFHRLVKRGELQQAWGALSKPTQDALAQRAQVVGEASGGEEKPEPMALFFANVPPPPDVTEVSLVREEGDVATVLVRAGESSHEVRMVREPSGWKVDLSASLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0F5</accession>
    <name>Q1D0F5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5730"/>
    <dbReference type="EnsemblBacteria" id="ABF86969">
        <property type="protein sequence ID" value="ABF86969"/>
        <property type="gene ID" value="MXAN_5730"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5730"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028398_5_0_7"/>
    <dbReference type="OMA" id="RALLHNC"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03487">
        <property type="entry name" value="RT_Bac_retron_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="348" mass="39194" checksum="12211B20978EC8FD" modified="2006-07-11" version="1">MARQPWPVPSLSTQAELAEWLGVTGAQLDWLADVPGIERTSSPGRWRRYRYTWIPKRSGGERLLERPGLDLVLVQRKLLHDILDHIPPHDAAHGFVAGRSVRRFAEPHARQAVVVRVDIEDFFFAVRPARIWAVFRTAGYPDGVVRALAGLCTNRTPSAVVSQARRPDSLADASTRWRLARRLESRHLPQGAPTSPALANLAAYRLDVRLSALAEAMGARYTRYADDMAFSGGDALARRTHKLLRYVSQILREEGFTPRTGKTRVMHRSTQQRLAGVVVNDHPSIRRVDYERLKAILHLCRTRGPASQNTEGHPDFRAHLLGRIAWVAHLHPARGAKLRATFDQIAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D179</accession>
    <name>Q1D179_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5451"/>
    <dbReference type="EnsemblBacteria" id="ABF86190">
        <property type="protein sequence ID" value="ABF86190"/>
        <property type="gene ID" value="MXAN_5451"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5451"/>
    <dbReference type="HOGENOM" id="CLU_2936774_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="60" mass="6561" checksum="EB9C4E5B32F87AA0" modified="2006-07-11" version="1">MKDASRLKRGRNVLRTDVRALLTTDVCELGNAPTAAPTAAEAKRRPARRTARMSSFSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1C1</accession>
    <name>Q1D1C1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5405"/>
    <dbReference type="EnsemblBacteria" id="ABF87048">
        <property type="protein sequence ID" value="ABF87048"/>
        <property type="gene ID" value="MXAN_5405"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5405"/>
    <dbReference type="HOGENOM" id="CLU_729036_0_0_7"/>
    <dbReference type="OMA" id="RCAYCES"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="439" mass="49513" checksum="A8D8ECF19B989B63" modified="2006-07-11" version="1">MPPVRIAPCYRPHRSAVRTRGGKQRMSERHIEMFWRCSSCSHRNLGRYMVCQGCKNAKDGSEQYEMPEDTASAVTVTDEALLRMATAGPNWRCAYCESDQRALDGGCKHCGASAVEGSIPAEPTRPTPDEKKGAKSNRRLGCYILSIIAFFGCCCPMWMSSGKKGTAPATAATTAPKTEPERTRTLQVKEVSWEHTVSVERYRLVNDEGFEEDRPEGALLVKAHGKRHHHDDQVLAGYTTVRYTERVQRGFTTETYRAKEACGEDCTTTPKKCSEQCTSNRNGFATCKTTCTGGGRSCTTRYCSVTKKRQEPRYVDEQRSRQEPRYRSVPRQATWYTWKEWRWMHDRDVKANGTTLEARWPTDAELRPAKALGKGEKERNARDARYSVVFHGDDQPAITYTPETLEEFQRFAPGSTHTLQQEQGKVSVVPQTPPAQATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1F3</accession>
    <name>Q1D1F3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_5370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555335.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5370"/>
    <dbReference type="EnsemblBacteria" id="ABF88058">
        <property type="protein sequence ID" value="ABF88058"/>
        <property type="gene ID" value="MXAN_5370"/>
    </dbReference>
    <dbReference type="GeneID" id="41362638"/>
    <dbReference type="KEGG" id="mxa:MXAN_5370"/>
    <dbReference type="eggNOG" id="COG5542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036370_3_1_7"/>
    <dbReference type="OMA" id="VHSNLAF"/>
    <dbReference type="OrthoDB" id="1297390at2"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
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            <end position="120"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF88058.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="377" mass="41622" checksum="06D3B51FDFC0770C" modified="2006-07-11" version="1">MARSASRTIVLVVLSAVVACGAAATAGAWRFFHKDPNNPVVRLDEYFTMGWVAWDSSWYMRIAQEGYQFAPGQQSSVAFFPLYPLLIRAVESLGPNVYQSGVLITLLCGPLALMLFTVWARKLTDEDTALKAGLLMACYPFTLYFYGAMYSDALFVLLVVAAFLLLERGHLGPAVLVAAVATAARPVAPAVVLGLLVRRLEWKHARGEKWSAVDFLPVLSGLGFGAYMLFLWHQFGDPVAFVKVQGSPGWEQIPGWHTWLKVSWFERVVLAPQDKREAFRLAAHAFFTLLALALVWPTRKLLGWGYAVYVLAIVGLPAWSTKDFMGMGRYLLSAFPVFLTAAMLLRERPLLLRGALAVGAASLLVLSWAFGADYYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1K8</accession>
    <name>Q1D1K8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_5314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574223">
            <id>Q1D1K8</id>
        </interactant>
        <interactant intactId="EBI-1574045">
            <id>Q1CWA4</id>
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        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>4</experiments>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="190"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="466" mass="50884" checksum="51C6B228B59CC926" modified="2006-07-11" version="1">MKRGRPRAHKRGWDAWGEPRECGPWGHRHPPHGYWHMGRLGGFVRARLHRRLFMWFGLSILATGAVVATVMSLVGGGTWKQEGDRVRAFVGHRFEEVWDEPARRDALVASIEKDLQVGVELRDASGAMLAQSQVPCRRPELNLPVVRDGITLGSVRACYASFRPKNPLRMVLPLALSCMVLWLASGKLARRLARPMDALVRATRELGSGRLDSRADVAPHVTGEFAVLADAFNDMAGRIEKQVADQRELLAAVSHELRTPLARLRVLTELLRDGGGNPKTLDQVDREVVELDALVGELLASSRLDFGQLTPRVLDGQTLATQALERAGLASSLLGMDVERAGLVGDATLLGRALANLLENARKHGTGAEALRIQERGEHLAFCVEDRGPGLQPGEDERIFRPFYRRDQGTEAREAGSLGLGLALVQRIAHVHGGDVFAENRPGGGARVGFTVRKNGPPASEGRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1K9</accession>
    <name>Q1D1K9_MYXXD</name>
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        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">MXAN_5313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
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            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF92103.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF92103">
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        <property type="gene ID" value="MXAN_5313"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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    </dbReference>
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        <property type="entry name" value="WalR-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF92103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24541" checksum="63CE772E6AEE2693" modified="2006-07-11" version="1">MSTRVLLIDDDTRMYELLEQYLGQNGLSVTHAADGGRGLAALEASAFDAVLLDVMMPGMDGLEVCKRIRAKSRIPVIMLTAKGDETDRVVGLELGADDYLPKPFSPRELLARLRAVLRRSQPSAVADRLESGGVSIDVAGREVRVEERAVELTGLEFDLLVALVRRAGRVVPRDALLGEAGRSDTVVGERTVDVHISHLRQKLGDVGTRLIKTVRGVGYVFAKEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1S4</accession>
    <name>Q1D1S4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase, family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_5247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555214.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5247"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90842">
        <property type="protein sequence ID" value="ABF90842"/>
        <property type="gene ID" value="MXAN_5247"/>
    </dbReference>
    <dbReference type="GeneID" id="41362526"/>
    <dbReference type="KEGG" id="mxa:MXAN_5247"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565989_0_0_7"/>
    <dbReference type="OMA" id="NEGSNSY"/>
    <dbReference type="OrthoDB" id="302519at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="510" mass="53897" checksum="E80F05F940BC3DE1" modified="2006-07-11" version="1">MGQGAEGLYFLFCWYFVLTRAPPSGGGSMRKFPRILALTVVCAVSAFASGCGDERNDTPLAEEAPAGTAGASLACSTRITYGERWIRPSGHTAQYDIASGLVTWDGTCINEGSNSYAVLSNGWRPYFTGNNACVMALDTDCAGATACSTRVTYAASWLHPSGHPSQYDDVSGRVFWDRACTNEGSNSYAVLSNGWRPYFSGTGACGMSFRYTGCGGLYRNPVVPVDCADPGVIYDGTRYVAACTSGGAANAFSLRTSTDLVTWTSAGSIFPSASKPTWATGDFWAPEIHKVGTRYIAYFTARHSNGKLSIGAATSASALGPFTDIGRPLVHDTAMGMIDATFFTSTTGAPYLVWKADGNAVGRPTPIYGQALSADGLSLVGSRQTLISNNLSWEGGVVEAPWVVARGGYYYLFYSGNAYYNSTYAVGVARATSPLGPYTKLGSPILKTGGGWVGPGHNSVVTGPRGDMYMVYHAWNSAHTARVMLVDAITWPNGWPAVPSAPSASSRPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D5</accession>
    <name>Q1D2D5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_5033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93083">
        <property type="protein sequence ID" value="ABF93083"/>
        <property type="gene ID" value="MXAN_5033"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5033"/>
    <dbReference type="HOGENOM" id="CLU_1693592_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF93083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="155" mass="16381" checksum="3DA1AF98F261D9EB" modified="2006-07-11" version="1">MMVLHMTKLRGFVGAAVLVMLSACGPAEEQLSGDGELSSSSIELSSVIPVPDAEMLQALTSSCQPASEGNCIGAGYLVCTDWSAQYECAPKTACDPLNPICKTRVDGQLVTTGTEYQDRNSYRVCSNSQGGTCTEFRFDRARTCGCGGGYPISET</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M7</accession>
    <name>Q1D2M7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_4940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554918.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4940"/>
    <dbReference type="EnsemblBacteria" id="ABF92226">
        <property type="protein sequence ID" value="ABF92226"/>
        <property type="gene ID" value="MXAN_4940"/>
    </dbReference>
    <dbReference type="GeneID" id="41362225"/>
    <dbReference type="KEGG" id="mxa:MXAN_4940"/>
    <dbReference type="eggNOG" id="COG4689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949375_0_0_7"/>
    <dbReference type="OMA" id="GRTIWGY"/>
    <dbReference type="OrthoDB" id="978501at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="293" mass="32737" checksum="49FD877B6A923C51" modified="2006-07-11" version="1">MLFRLPSRIQAQSGRYSRVDGIPYTLPINSKSSPVLMAAFTVDAEQAARLLPGNELHPLRVSRRRGVLLVTVIDYRTTDIGAYIEFSIAIACTRGPRPSRPLLPLMFQKRHGLGQYVFDLPVNTEVSVKGGKGIWGMPKHLANLDFRIQDGTVSSRYDEGGQQVALIEIDRPRRAWLPLYATAVNYCAFRGMLFKSYIYFRGKFGFRLGKRAGARLVMGDHPRIRPLRALGISRRAFFTSFLPTSSGVLDDHFETWFLSQAVLPAETYPEGLESVMGMGQGKTPQKPPGPPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M9</accession>
    <name>Q1D2M9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554916.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF91491">
        <property type="protein sequence ID" value="ABF91491"/>
        <property type="gene ID" value="MXAN_4938"/>
    </dbReference>
    <dbReference type="GeneID" id="41362223"/>
    <dbReference type="KEGG" id="mxa:MXAN_4938"/>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244980_0_0_7"/>
    <dbReference type="OMA" id="GLRDHRI"/>
    <dbReference type="OrthoDB" id="38369at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="108" mass="11897" checksum="FF68D4C88C7852EA" modified="2006-07-11" version="1">MTDAIIVLVTAPTEDKAAELARALVEAQLAACGNIVPGLRSIYRWEGKVQDEPEVLLLLKTRAALFEPLRARIVELHPYNVPEVLRVDIAEGHAPYLSWILGSTRAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3H8</accession>
    <name>Q1D3H8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">nadB</name>
        <name evidence="15" type="ORF">MXAN_4629</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554622.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4629"/>
    <dbReference type="EnsemblBacteria" id="ABF90864">
        <property type="protein sequence ID" value="ABF90864"/>
        <property type="gene ID" value="MXAN_4629"/>
    </dbReference>
    <dbReference type="GeneID" id="41361929"/>
    <dbReference type="KEGG" id="mxa:MXAN_4629"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_7"/>
    <dbReference type="OMA" id="DSPDIHY"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="13">
        <location>
            <begin position="6"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="14">
        <location>
            <begin position="434"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABF90864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="58437" checksum="2390FAE2B3961F40" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3M0</accession>
    <name>Q1D3M0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="6" type="ORF">MXAN_4585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554580.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4585"/>
    <dbReference type="EnsemblBacteria" id="ABF90882">
        <property type="protein sequence ID" value="ABF90882"/>
        <property type="gene ID" value="MXAN_4585"/>
    </dbReference>
    <dbReference type="GeneID" id="41361885"/>
    <dbReference type="KEGG" id="mxa:MXAN_4585"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_7"/>
    <dbReference type="OMA" id="INSEIMM"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="14"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="389" mass="43361" checksum="BA8055CF28FA95EC" modified="2006-07-11" version="1">MAVRFELLTTDPTGARAGILHTRRGSFKTPMFMPVATHAGFRHLAMEEVKEAGASILLANTYHLMLRPGAEVFKRFGGIHPFMQWDGGVLTDSGGFQIFSLPEDRLITEKGAHFRSFYDNSRQLLSPESSIAMQQAINSEIMMVLDVCIDSRTDEAGTREAMERTHRWAVRSLEAKAARDTGQAMFGIVQGGVFPHLRDESAAFLTKLPFDGFAIGGLAVGETKVERESMTLRATASLPADKPRYLMGVGTPTDLVEAVLRGVDMFDCIIPTKMAQQGYAYTFSGLIRISRSVFRLSDEPLDAECDCYVCKRYTRGYLQHLMRGKHHLGSRFLSVHNVRHYQKLMGRIREGILSGTYAQVYRELKAAIATPKDLKDEANAREVTLKEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D453</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">MXAN_4397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4397"/>
    <dbReference type="EnsemblBacteria" id="ABF92243">
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        <property type="gene ID" value="MXAN_4397"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1667509_0_0_7"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="158" mass="17703" checksum="544B8C04B0483E06" modified="2006-07-11" version="1">MAPRRPKQLRPESQARQTSQVRSRRSVVGGRRMARAVGGDVVVKFLGEVVELRHELRATQGDIEGMAMGMESMRAGMATMRSNMAAMQSNMDSMMGNMETMMSTVESMIVGLRSVSGRMSRMEAHAGRMARLLTSMADSTQERFERVEKRLDDLEDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B0</accession>
    <name>Q1D4B0_MYXXD</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">MXAN_4340</name>
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    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4340"/>
    <dbReference type="EnsemblBacteria" id="ABF87920">
        <property type="protein sequence ID" value="ABF87920"/>
        <property type="gene ID" value="MXAN_4340"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_4340"/>
    <dbReference type="eggNOG" id="ENOG5033FPG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007756_0_0_7"/>
    <dbReference type="OMA" id="RKEPDWC"/>
    <dbReference type="OrthoDB" id="173729at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="772" mass="85166" checksum="E2F9B65DD28962E8" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4H8</accession>
    <name>Q1D4H8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation-transporting ATPase, E1-E2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_4270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554273.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4270"/>
    <dbReference type="EnsemblBacteria" id="ABF92362">
        <property type="protein sequence ID" value="ABF92362"/>
        <property type="gene ID" value="MXAN_4270"/>
    </dbReference>
    <dbReference type="GeneID" id="41361585"/>
    <dbReference type="KEGG" id="mxa:MXAN_4270"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_7"/>
    <dbReference type="OMA" id="DTRMANY"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF92362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="810" mass="85881" checksum="F68AE194070964FE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4S9</accession>
    <name>Q1D4S9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4123 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4169"/>
    <dbReference type="EnsemblBacteria" id="ABF86957">
        <property type="protein sequence ID" value="ABF86957"/>
        <property type="gene ID" value="MXAN_4169"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4169"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118575_0_0_7"/>
    <dbReference type="OMA" id="WGRGWGI"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025391">
        <property type="entry name" value="DUF4123"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13503">
        <property type="entry name" value="DUF4123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4123" evidence="1">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="175" mass="19401" checksum="6A5E5F378324FA27" modified="2006-07-11" version="1">MRQATEEAPTSALYAILDGARAPNIHRLVLTCGLTQSCLYAGKLPPELVEVAPYLVQLRPGAPATEQLLAAGWGKSWGIFVQSPAHPDALRRHLRRFLKVKDANGKPLVFRYYDPRVLRVYLPTCTDDELDFLFGPIEQFFAESEDGGSMLAYARRPEEAPLDAPPLTVLPTPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4X8</accession>
    <name>Q1D4X8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase orf1, IS66 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554123.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4117"/>
    <dbReference type="EnsemblBacteria" id="ABF90791">
        <property type="protein sequence ID" value="ABF90791"/>
        <property type="gene ID" value="MXAN_4117"/>
    </dbReference>
    <dbReference type="GeneID" id="41361443"/>
    <dbReference type="KEGG" id="mxa:MXAN_4117"/>
    <dbReference type="eggNOG" id="COG3436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128110_0_0_7"/>
    <dbReference type="OMA" id="RGQFKLP"/>
    <dbReference type="OrthoDB" id="1680806at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13422" checksum="F2DEA08FCDAF6498" modified="2006-07-11" version="1">MFSLPASVRVVLATTPVDMRKSIDGLMALVRAEWGEDVYSGHLFAFVSRRGDRVKVLTWSRGGFVLLYKRLETGRFWLPPVDAGAQVVHLDATQLAMLLDGIDVAQVRRQPAWTPPGRTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4Z7</accession>
    <name>Q1D4Z7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4098"/>
    <dbReference type="EnsemblBacteria" id="ABF87124">
        <property type="protein sequence ID" value="ABF87124"/>
        <property type="gene ID" value="MXAN_4098"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4098"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1293209_0_0_7"/>
    <dbReference type="OMA" id="RDPLGWR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="215" mass="22672" checksum="D245B1D762C84AC2" modified="2006-07-11" version="1">MSTPRSRVFMAASRQGGGRALRLVSGDAQPDSPYPKASLWLRGGARAVDVSVAWGLYVVGGAAGAVVALLFLLLADGMLQGQSVGKRIFGVKVMHLPTRSAARHRDSTLRNAPLALIVLLGMMPAPHGTVAAAAGLIVIGSVEAWCVLRDPLGWRLGDTWAQTQVVDGKVVAGVTVAARTPVAHERASGRLMSAAKVRRGRSSFRKRRGYPCASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D592</accession>
    <name>Q1D592_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-ribosomal peptide synthase/polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_4001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554011.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4001"/>
    <dbReference type="EnsemblBacteria" id="ABF89749">
        <property type="protein sequence ID" value="ABF89749"/>
        <property type="gene ID" value="MXAN_4001"/>
    </dbReference>
    <dbReference type="GeneID" id="41361332"/>
    <dbReference type="KEGG" id="mxa:MXAN_4001"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_21_2_7"/>
    <dbReference type="OMA" id="RRYGPTI"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="921"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3227"/>
            <end position="3301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2229"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3208"/>
            <end position="3227"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF89749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="3780" mass="406185" checksum="A3AAFB8058529BD1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5K2</accession>
    <name>Q1D5K2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Group II decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_3891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3891"/>
    <dbReference type="EnsemblBacteria" id="ABF90469">
        <property type="protein sequence ID" value="ABF90469"/>
        <property type="gene ID" value="MXAN_3891"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3891"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005446_2_0_7"/>
    <dbReference type="OMA" id="LSWGHIT"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF90469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="720" mass="78769" checksum="7A7518620B95DA68" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L4</accession>
    <name>Q1D5L4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">MXAN_3879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3879"/>
    <dbReference type="EnsemblBacteria" id="ABF87284">
        <property type="protein sequence ID" value="ABF87284"/>
        <property type="gene ID" value="MXAN_3879"/>
    </dbReference>
    <dbReference type="GeneID" id="41361212"/>
    <dbReference type="KEGG" id="mxa:MXAN_3879"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_7"/>
    <dbReference type="OMA" id="CACSETT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="255"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="355"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="598"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="747"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="862" mass="94794" checksum="344F5505F9EFA0EE" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5Y4</accession>
    <name>Q1D5Y4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxybutyryl-CoA dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crt</name>
        <name evidence="3" type="ORF">MXAN_3757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2016" name="ChemBioChem" volume="17" first="1658" last="1664">
            <title>The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus, Reveals Insights into Specificity and Catalysis.</title>
            <authorList>
                <person name="Bock T."/>
                <person name="Reichelt J."/>
                <person name="Muller R."/>
                <person name="Blankenfeldt W."/>
            </authorList>
            <dbReference type="PubMed" id="27271456"/>
            <dbReference type="DOI" id="10.1002/cbic.201600225"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) IN COMPLEX WITH COENZYME A</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553770.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="5JBW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A=1-258"/>
    </dbReference>
    <dbReference type="PDB" id="5JBX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.10 A"/>
        <property type="chains" value="A/B/C=1-258"/>
    </dbReference>
    <dbReference type="PDBsum" id="5JBW"/>
    <dbReference type="PDBsum" id="5JBX"/>
    <dbReference type="SMR" id="Q1D5Y4"/>
    <dbReference type="STRING" id="246197.MXAN_3757"/>
    <dbReference type="EnsemblBacteria" id="ABF91920">
        <property type="protein sequence ID" value="ABF91920"/>
        <property type="gene ID" value="MXAN_3757"/>
    </dbReference>
    <dbReference type="GeneID" id="41361089"/>
    <dbReference type="KEGG" id="mxa:MXAN_3757"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="AMEMIMT"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="BRENDA" id="4.2.1.18">
        <property type="organism ID" value="3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003859">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Coenzyme A</name>
            <dbReference type="ChEBI" id="CHEBI:57395"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5JBW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5JBX"/>
        </source>
    </evidence>
    <sequence length="258" mass="27401" checksum="F241D82EF5D46645" modified="2006-07-11" version="1">MPEFKVDARGPIEIWTIDGESRRNAISRAMLKELGELVTRVSSSRDVRAVVITGAGDKAFCAGADLKERATMAEDEVRAFLDGLRRTFRAIEKSDCVFIAAINGAALGGGTELALACDLRVAAPAAELGLTEVKLGIIPGGGGTQRLARLVGPGRAKDLILTARRINAAEAFSVGLANRLAPEGHLLAVAYGLAESVVENAPIAVATAKHAIDEGTGLELDDALALELRKYEEILKTEDRLEGLRAFAEKRAPVYKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D612</accession>
    <name>Q1D612_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase S24-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3726"/>
    <dbReference type="EnsemblBacteria" id="ABF87963">
        <property type="protein sequence ID" value="ABF87963"/>
        <property type="gene ID" value="MXAN_3726"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3726"/>
    <dbReference type="eggNOG" id="COG2932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2143156_0_0_7"/>
    <dbReference type="OMA" id="LEMDRWD"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="126" mass="13837" checksum="A7E02FA9BDE604D6" modified="2006-07-11" version="1">MPPALSWVPVHGDSMWPSLRSGDHAGVEPLEGAPRPGDVLLARFDHALVLHRLRRWEAGAVALRGDNSPQDDAPLDPSRVLGRVRRVRRGGVVLEAGWDRGPRWLGRVRVAVKWRLAALLGRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6E4</accession>
    <name>Q1D6E4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">MXAN_3589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553615.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3589"/>
    <dbReference type="EnsemblBacteria" id="ABF89217">
        <property type="protein sequence ID" value="ABF89217"/>
        <property type="gene ID" value="MXAN_3589"/>
    </dbReference>
    <dbReference type="GeneID" id="41360935"/>
    <dbReference type="KEGG" id="mxa:MXAN_3589"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_7"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="235" mass="25783" checksum="7B402E006B7D5E7C" modified="2006-07-11" version="1">MTKLESLHKEITDCRACPRLVEWREEVARVKRRAYRDWNYWGLPVPGFGDPKARLIIVGLAPAAHGANRTGRMFTGDRSGDFLYAGLHRAGFANQALSEHRDDGLRLKDAFIVSAARCAPPDNKPLPEELARCAPFLDRELALLPGRVMLALGAIGWNAALVALARQGMEVPSPRPAFGHGAELRLPGGRTLLGCYHVSQQNTQTGRLTPAMFDAVMSRVHTLLETADPKARGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6K3</accession>
    <name>Q1D6K3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">MXAN_3526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3526"/>
    <dbReference type="EnsemblBacteria" id="ABF86718">
        <property type="protein sequence ID" value="ABF86718"/>
        <property type="gene ID" value="MXAN_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3526"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_1_1_7"/>
    <dbReference type="OMA" id="YRNIPEW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="32350" checksum="2EC6AE3D0FE5E971" modified="2006-07-11" version="1">MGGSVGGKRPDEPAGSGRAPGALRVLRVERPEGTRVRVGPVEVGGPGFVVMAGPCAVEGAEQVQHAASVVAAAGAHVLRGGVFKPRTSPYAFQGMGEPGLHVLAEAGRRHGMPIISEVMESAQIPLMEESTDILQVGARNMQNYSLLRALGKVRKPVLLKRGLSATLQEWLLAAEYILDGGNEQVMLCERGIRTFETELRNTLDLAAVAWAKQRSHLPVIVDPSHATGDPALILPMSLAAAAAGADGLLIEVHPKPEQAMCDGHQALTPERFETLMRRLPAVLDAVDRHLWRPESPAQVVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6X4</accession>
    <name>Q1D6X4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_3402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3402"/>
    <dbReference type="MEROPS" id="M15.002"/>
    <dbReference type="EnsemblBacteria" id="ABF86907">
        <property type="protein sequence ID" value="ABF86907"/>
        <property type="gene ID" value="MXAN_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3402"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1487528_0_0_7"/>
    <dbReference type="OMA" id="RSEPWHW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="202" mass="23173" checksum="52F18B2DE87B0F27" modified="2006-07-11" version="1">MRRGTDARKFGFRPRGRLPNMSLALLRWGVFILLCLFAPQAVAGDAKPRRSEAKGSRLVRLKNGQLLHTDAADAYRRMKAEARSKNIYLWVHSGYRSPAKQRRLYERYRKGKGPQAARPGRSNHQRGLAVDLVIGGVKTPTYDWLVSNACRFGFKRTVRSEPWHWEYRPHSTREPKPGRDCVGRPLKRQRPQSPPVASTEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D722</accession>
    <name>Q1D722_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553387.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3354"/>
    <dbReference type="EnsemblBacteria" id="ABF92897">
        <property type="protein sequence ID" value="ABF92897"/>
        <property type="gene ID" value="MXAN_3354"/>
    </dbReference>
    <dbReference type="GeneID" id="41360704"/>
    <dbReference type="KEGG" id="mxa:MXAN_3354"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030483_0_0_7"/>
    <dbReference type="OMA" id="ARKAMYQ"/>
    <dbReference type="OrthoDB" id="854733at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="588" mass="65836" checksum="52643FD0BD1EB227" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D763</accession>
    <name>Q1D763_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ORF">MXAN_3311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3311"/>
    <dbReference type="EnsemblBacteria" id="ABF86646">
        <property type="protein sequence ID" value="ABF86646"/>
        <property type="gene ID" value="MXAN_3311"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3311"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_7"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF86646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="174" mass="19465" checksum="37D79F767288C730" modified="2006-07-11" version="1">MRFFKEGVPSLLKELSLKNPMQVPRLEKIVVNMGLGEALANNKILESAVEQLAAITGQKPIVTRARKSIANFKLRQGQAIGAAVTLRGDRMYEFMDRLITVALPRVRDFKGVSPKAFDGKGNYTLGVREQIIFPEINYDQIEKVKGLNISFVTTAANDEQGLALMRHFGMPFRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D773</accession>
    <name>RL23_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">MXAN_3301</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002633606.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D773"/>
    <dbReference type="SMR" id="Q1D773"/>
    <dbReference type="STRING" id="246197.MXAN_3301"/>
    <dbReference type="PRIDE" id="Q1D773"/>
    <dbReference type="EnsemblBacteria" id="ABF87941">
        <property type="protein sequence ID" value="ABF87941"/>
        <property type="gene ID" value="MXAN_3301"/>
    </dbReference>
    <dbReference type="GeneID" id="41360654"/>
    <dbReference type="KEGG" id="mxa:MXAN_3301"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_7"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000272780" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="97" mass="10856" checksum="4C6C69583788D02F" modified="2006-07-11" version="1">MNLNDVIKGPLITEKLDKAREKFRQYSFIVDRKATKHDVARAVETLFKVTVEGVNTNIVRGKIKRVGRSIGKRPNFKKAVVTLKQGDSIELFEGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D830</accession>
    <name>Q1D830_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH family/DHHA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2984"/>
    <dbReference type="EnsemblBacteria" id="ABF86561">
        <property type="protein sequence ID" value="ABF86561"/>
        <property type="gene ID" value="MXAN_2984"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2984"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_0_0_7"/>
    <dbReference type="OMA" id="KCATALM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="343" mass="38135" checksum="7B2D3D5766E75877" modified="2006-07-11" version="1">MPARDKLERLLRVAQGHHKALILTHDNPDPDSLAAAVALAHLLERKAGLKAHIGYGGIIGRAENIAFVKVLRLPVSHVSTIDFDEYDLFGLVDTQPKVGNHSLPARLQAHLVVDHHPLRQESLEAPFADVGGDFGATSTMLVEYLRAARLEPSAEVATGLFYGIKADTRDLGRETTPTDVDSYLWLFPRMDKMLLAQIEHPELPARYFQLYHTAYERAKVYGTAIVTDLEEVYSPDMVAEVAERLMFLEGMKWSLAFGTYRNQLFLSLRVKDRRMNAGRLIREICEDYGGSSGGHGSMAGARLPLSGKLAQRKALKRELVAKFLEAFGVANERPVSLLYAQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8M1</accession>
    <name>Q1D8M1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_2785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574080">
            <id>Q1D8M1</id>
        </interactant>
        <interactant intactId="EBI-1574166">
            <id>Q1D948</id>
            <label>MXAN_2606</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1574080">
            <id>Q1D8M1</id>
        </interactant>
        <interactant intactId="EBI-1574240">
            <id>Q1CWQ1</id>
            <label>MXAN_7059</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552852.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q1D8M1">
        <property type="interactions" value="16"/>
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        <property type="protein sequence ID" value="ABF90567"/>
        <property type="gene ID" value="MXAN_2785"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2785"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
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    <dbReference type="OrthoDB" id="1755994at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="His_kinase_dom"/>
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    </dbReference>
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        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="426"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="501"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="550"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="703"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="951"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="392"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1000"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119266" checksum="7D2C07D6F0E5B65A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D911</accession>
    <name>Q1D911_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86634.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2643"/>
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        <property type="protein sequence ID" value="ABF86634"/>
        <property type="gene ID" value="MXAN_2643"/>
    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_2643"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_7"/>
    <dbReference type="OMA" id="ENARNFR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF86634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="364" mass="39506" checksum="8701CC5F397A26CA" modified="2006-07-11" version="1">MNPADLLSAMKRTVEQLAAFNEMAKALTSTLELREVLALVMQKVSSLLLPRNWSLILQDERTGKLYFEIAVGDGADVLKGLQLNPGEGIAGAVFTSGAARLVHDVGGDPSFSPRFDEASAFHTRSILAVPLLARGRVLGIIELVNGPMDPPFTNEDLTILTAIADYAAIAIENARNFRRVQELTITDEHTGCYNARHLRALLDQEVKRSERFSHPLSLVFLDLDHFKSINDTHGHLVGSATLKEVGDLLMTLGRQNLDAVFRYGGDEFAMLLVETDPEGAAVIGQRVCEAFRGRGFLLEQGLDVRLTASVGVATYPDHASSALDLIRAADFAMYAAKARGRDALCIAEPIAPNGGTGSHEFPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D913</accession>
    <name>Q1D913_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552711.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2641"/>
    <dbReference type="EnsemblBacteria" id="ABF90783">
        <property type="protein sequence ID" value="ABF90783"/>
        <property type="gene ID" value="MXAN_2641"/>
    </dbReference>
    <dbReference type="GeneID" id="41360017"/>
    <dbReference type="KEGG" id="mxa:MXAN_2641"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_3_7"/>
    <dbReference type="OMA" id="PLDIEWH"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF90783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="227" mass="24244" checksum="578CA2B80DD350E5" modified="2006-07-11" version="1">MSGSVAERLASVRERVVAACARAGRPVESVTLVAVSKLKPADLIREAYAAGQRDFGENYAQELRDKAAELADLEGLRWHSIGALQTNKVKYVARAAGAFHALDRLEVARELSKRREGAPPLPVYVEVNVGGEATKSGLAPDALGAFLDEVRALPGLQAVGLMALPPPTEDEARARADFQALRELARVHGLPGLSMGTTHDFEWAIEEGATVVRVGTAIFGERALKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D917</accession>
    <name>Q1D917_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552707.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2637"/>
    <dbReference type="EnsemblBacteria" id="ABF89121">
        <property type="protein sequence ID" value="ABF89121"/>
        <property type="gene ID" value="MXAN_2637"/>
    </dbReference>
    <dbReference type="GeneID" id="41360013"/>
    <dbReference type="KEGG" id="mxa:MXAN_2637"/>
    <dbReference type="eggNOG" id="ENOG502ZI6A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073797_3_0_7"/>
    <dbReference type="OMA" id="VCFDVYG"/>
    <dbReference type="OrthoDB" id="1968186at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188331" evidence="2">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF89121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="298" mass="33346" checksum="8C94A535459AB57C" modified="2006-07-11" version="1">MSPLRTLFAALLSLSSVSAWAQLPDAEADAPEAESAKAEEPEAPLTVAPCNAALPALRTPLAFMPGEVLEFDLDAMGAQAGTMTMRVHKQKDGHLPIQVEAQTNTFFSKVRRVRGSATAYLHPRTLRPNRYVEDTMENEQRRKVEVAFGQKERTVKVDYQFGQRPKGQFNYTFDKDGLDVAGAIYLLRQLPLKDDLQVCFDVYGVRRMWRMQGAVVKREQVTTPLGQFNAWHVTGTAVRLDRPKQKREVHVWISDDARRLPLAAVGTIDLGAVRATLTSVSRPGEKPQKSEGQETMKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D936</accession>
    <name>PURA_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylosuccinate synthetase</fullName>
            <shortName evidence="1">AMPSase</shortName>
            <shortName evidence="1">AdSS</shortName>
            <ecNumber evidence="1">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purA</name>
        <name type="ordered locus">MXAN_2618</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552688.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D936"/>
    <dbReference type="SMR" id="Q1D936"/>
    <dbReference type="STRING" id="246197.MXAN_2618"/>
    <dbReference type="EnsemblBacteria" id="ABF87700">
        <property type="protein sequence ID" value="ABF87700"/>
        <property type="gene ID" value="MXAN_2618"/>
    </dbReference>
    <dbReference type="GeneID" id="41359995"/>
    <dbReference type="KEGG" id="mxa:MXAN_2618"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_7"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000000875" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="305"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="419"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <sequence length="436" mass="46980" checksum="6AC33444C324D660" modified="2006-07-11" version="1">MPNVVVIGAQWGDEGKGKVVDLLTEHAQVVVRFQGGNNAGHTLVVGGQKTVLHLIPSGILHPGKTCVIGNGVVVDPAVLVGEIDALKVRGFLKDDAQLLISDNAHVIFPWHKLLDSFREKARGGSAIGTTGRGIGPAYEDKVARRGIRVRDLLNADRLRTRIEARLPAALDELKDLCAQAGDPVPQLEVPQILAEFTGLGERLKPFVHDASLYLSGQVRRGARILFEGAQGTLLDVDHGTYPFVTSSNCVAGNAAVGSGLGPTAIDKVMGISKAYTTRVGGGPFPTELHDAIGDQLRKMGDEFGTTTGRPRRCGWLDGVVLRYASRVNGLWGMALTKLDVLSGLKTLQICTAYELDGQKVMELPGDYEDLARVKPIYETLQGWDEQIAGVRTFDELPENAKRYVRRVEEVSGVPVVCVSVGADRGETVLLQNPFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9I3</accession>
    <name>Q1D9I3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552542.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2470"/>
    <dbReference type="EnsemblBacteria" id="ABF85962">
        <property type="protein sequence ID" value="ABF85962"/>
        <property type="gene ID" value="MXAN_2470"/>
    </dbReference>
    <dbReference type="GeneID" id="41359853"/>
    <dbReference type="KEGG" id="mxa:MXAN_2470"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520448_0_0_7"/>
    <dbReference type="OMA" id="ETGMAWQ"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="361"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF85962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="513" mass="53571" checksum="17C5D6A1AD726707" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9R6</accession>
    <name>Q1D9R6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552462.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2387"/>
    <dbReference type="EnsemblBacteria" id="ABF89971">
        <property type="protein sequence ID" value="ABF89971"/>
        <property type="gene ID" value="MXAN_2387"/>
    </dbReference>
    <dbReference type="GeneID" id="41359772"/>
    <dbReference type="KEGG" id="mxa:MXAN_2387"/>
    <dbReference type="eggNOG" id="ENOG5031W4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119975_0_0_7"/>
    <dbReference type="OMA" id="GREDMKM"/>
    <dbReference type="OrthoDB" id="1338914at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011751">
        <property type="entry name" value="Mxa_paralog_2265"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09536">
        <property type="entry name" value="DUF2378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02265">
        <property type="entry name" value="Mxa_TIGR02265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="196" mass="21969" checksum="7C4A6316E29CEE4A" modified="2006-07-11" version="1">MERRGFDDKTATEPRKPPPLPVQVPRRNFEGLFVHALKPTGSFAQSLRDIGYDMEASQEYYPLVVWRAALGVARRYACVGQPPEAANRVLGHRYVEGFAQTLVGRIFATAAPLLGTERCLTRLPTYLRAGREDMKMLLEPVQAGEWRIRVVDPDPLPDFVAGVVEGVLLRTKVLPQVEVLERQTAGYALRVRWTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9R8</accession>
    <name>Q1D9R8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucans biosynthesis protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mdoG</name>
        <name evidence="6" type="synonym">opgG</name>
        <name evidence="8" type="ORF">MXAN_2385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the OpgD/OpgG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552460.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2385"/>
    <dbReference type="EnsemblBacteria" id="ABF92764">
        <property type="protein sequence ID" value="ABF92764"/>
        <property type="gene ID" value="MXAN_2385"/>
    </dbReference>
    <dbReference type="GeneID" id="41359770"/>
    <dbReference type="KEGG" id="mxa:MXAN_2385"/>
    <dbReference type="eggNOG" id="COG3131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023403_2_0_7"/>
    <dbReference type="OMA" id="KRPSAWI"/>
    <dbReference type="OrthoDB" id="1049230at2"/>
    <dbReference type="UniPathway" id="UPA00637"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01069">
        <property type="entry name" value="MdoG_OpgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014438">
        <property type="entry name" value="Glucan_biosyn_MdoG/MdoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007444">
        <property type="entry name" value="Glucan_biosyn_MdoG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023704">
        <property type="entry name" value="MdoG_OpgG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30504">
        <property type="entry name" value="PTHR30504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04349">
        <property type="entry name" value="MdoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006281">
        <property type="entry name" value="MdoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009018904" description="Glucans biosynthesis protein G" evidence="6">
        <location>
            <begin position="30"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="MdoG" evidence="7">
        <location>
            <begin position="46"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF92764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="529" mass="58715" checksum="C906834B2FCF94F4" modified="2006-07-11" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W3</accession>
    <name>Q1D9W3_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="10">APS reductase</shortName>
            <ecNumber evidence="6 10">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cysH</name>
        <name evidence="12" type="ORF">MXAN_2340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 10">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552415.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2340"/>
    <dbReference type="EnsemblBacteria" id="ABF92398">
        <property type="protein sequence ID" value="ABF92398"/>
        <property type="gene ID" value="MXAN_2340"/>
    </dbReference>
    <dbReference type="GeneID" id="41359726"/>
    <dbReference type="KEGG" id="mxa:MXAN_2340"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_1_0_7"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="11">
        <location>
            <begin position="39"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="10">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF92398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="240" mass="26962" checksum="326DAFDA3CAD3DCC" modified="2006-07-11" version="1">MSPPQPQASALLAEAAEVKDAPAQDLLAWTERRFGARAAIASSFGVEDMVLIDLARQHAPSLRLFTLDTGRLPPETYELMEVVRKRYGVTVETYFPERARVEALESTNGYFSFRQSLEARKACCAIRKVEPLSRALAGQQAWVTGLRREQSVTRTDVATLEVDSAHGLLKLNPLATWSSRDIWAYVRAKSVPYNALHDRGYPSIGCAPCTRAVKPYEDERAGRWWWESAENRECGLHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA30</accession>
    <name>Q1DA30_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2272"/>
    <dbReference type="EnsemblBacteria" id="ABF89019">
        <property type="protein sequence ID" value="ABF89019"/>
        <property type="gene ID" value="MXAN_2272"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2272"/>
    <dbReference type="HOGENOM" id="CLU_2753672_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="70" mass="7519" checksum="66C8F46714A7FCB5" modified="2006-07-11" version="1">MLAHDAARDEGQWGLRDERRECVFEGWTPAEGFKRHGWKDSGQSGANGAPGSSGLPEERTAALCQTFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAF4</accession>
    <name>Q1DAF4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_2146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2146"/>
    <dbReference type="EnsemblBacteria" id="ABF91960">
        <property type="protein sequence ID" value="ABF91960"/>
        <property type="gene ID" value="MXAN_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2146"/>
    <dbReference type="eggNOG" id="ENOG5032TZU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142708_0_0_7"/>
    <dbReference type="OMA" id="TIRFFAM"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF91960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="136" mass="15361" checksum="0A45D557434B000E" modified="2006-07-11" version="1">MMQSREGNLLYGAPTPRSLAMANPVRFAFTQTAQPNLEFIVELSDEKTISHARKILSGEEKNEVHVHGRIIKRAAAYNPRFSFHLDPNTIRFFAMAIEVCDANMTYVEDHLDEAGGAFLPGGHWCPWDSKLTREIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAQ3</accession>
    <name>Q1DAQ3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cystathionine beta-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552125.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2041"/>
    <dbReference type="EnsemblBacteria" id="ABF91117">
        <property type="protein sequence ID" value="ABF91117"/>
        <property type="gene ID" value="MXAN_2041"/>
    </dbReference>
    <dbReference type="GeneID" id="41359450"/>
    <dbReference type="KEGG" id="mxa:MXAN_2041"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_0_0_7"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="338"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF91117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="455" mass="49362" checksum="ED0C0A023F266355" modified="2006-07-11" version="1">MDIHENILTAIGNTPLVKLNKLVGPNDATVLVKCEFMNPGASIKDRMALYILEKAEREGKLKPGGTIVENTSGNTGMGVALAAAVKGYKCIFTMPDKMSLEKINRLKALGAQVVVTPTNVPAEDPRSYYETAKRLHRETPGAFMLNQYHNPDNIEAHYNTTGPEIYKQTEGKFDYFVAGLGTGGTMSGAGKFLKEKIPGLKNVGVDPEGSVYEGYFKTGKLTEPHVYKVEGIGEDMLCGAMDFTHLDDVRQVDDRQCFIAARRLAREEGIFAGGSSGAAIHVAVQLAKEVGKGKTIVVVLPDSGSSYISKFHSDEWMRDNGFLEEKGAGTIRDILGDKRKDVKTARRGDKVDQVVETMRGHGISQMPVVGDDGRTVGMVHEYDLLNALVAGKAKFSDTIDSIIAPLQGALSLDTSIARLREVFAQDNVAVVKDGEKVVGIVTKIDLIDYLHRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAY0</accession>
    <name>Q1DAY0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cys/Met metabolism PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_1955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552048.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1955"/>
    <dbReference type="EnsemblBacteria" id="ABF87408">
        <property type="protein sequence ID" value="ABF87408"/>
        <property type="gene ID" value="MXAN_1955"/>
    </dbReference>
    <dbReference type="GeneID" id="41359368"/>
    <dbReference type="KEGG" id="mxa:MXAN_1955"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_7"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="394" mass="41974" checksum="37461958DC9431FB" modified="2006-07-11" version="1">MSSKQKTVAVHAGTRLAGSKAVPVSPPIYPAAVNWFDSSDDLDSALDGKDYAYARISAPNTTLLEEAVAALEGAEDCVAYASGMAALRSVFEAQGFRAGDKLVMPADGYGVTRALYKSLCATLGVELHAFLMTDPEVPERIRALKPRMVLAESISNPLLRVPDLRVLARACQDVGATFVVDGTFPSPVGQRALALGADYAVQSTSKWLNGHSDALGGTVSASRERMAPLRAARVLAGDVLGPFEAWLTLRGLRTLPVRMKAHVEHAAHVARRLMESPLLERVIYPGLTSHPDHATAQELLLGGGPMVAFEIKGAGRPESMRFLEALKVGRPGPSLGDVCTLVMHAASASARRFTPEEREAAGIRENLIRVSVGLEDPDDIVDDLLAAVAQGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB03</accession>
    <name>Q1DB03_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gliding motility protein MglB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mglB</name>
        <name evidence="3" type="ORF">MXAN_1926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2019" name="PLoS Biol." volume="17" first="e3000459" last="e3000459">
            <title>Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility.</title>
            <authorList>
                <person name="Baranwal J."/>
                <person name="Lhospice S."/>
                <person name="Kanade M."/>
                <person name="Chakraborty S."/>
                <person name="Gade P.R."/>
                <person name="Harne S."/>
                <person name="Herrou J."/>
                <person name="Mignot T."/>
                <person name="Gayathri P."/>
            </authorList>
            <dbReference type="PubMed" id="31560685"/>
            <dbReference type="DOI" id="10.1371/journal.pbio.3000459"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS)</scope>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-8019001">
            <id>Q1DB03</id>
        </interactant>
        <interactant intactId="EBI-7643442">
            <id>Q1DB04</id>
            <label>mglA</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002637270.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="PDB" id="6IZW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="B/C=1-159"/>
    </dbReference>
    <dbReference type="PDBsum" id="6IZW"/>
    <dbReference type="SASBDB" id="Q1DB03"/>
    <dbReference type="SMR" id="Q1DB03"/>
    <dbReference type="IntAct" id="Q1DB03">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q1DB03"/>
    <dbReference type="STRING" id="246197.MXAN_1926"/>
    <dbReference type="EnsemblBacteria" id="ABF91419">
        <property type="protein sequence ID" value="ABF91419"/>
        <property type="gene ID" value="MXAN_1926"/>
    </dbReference>
    <dbReference type="GeneID" id="41359340"/>
    <dbReference type="GeneID" id="64080068"/>
    <dbReference type="KEGG" id="mxa:MXAN_1926"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128755_0_0_7"/>
    <dbReference type="OMA" id="KEALWAP"/>
    <dbReference type="OrthoDB" id="1584836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="PTHR13323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="15"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6IZW"/>
        </source>
    </evidence>
    <sequence length="159" mass="17193" checksum="637AB5901AE6FB40" modified="2006-07-11" version="1">MGTQLVMYEEEFTKINAVCDRLTKDANAKVVFLVDKNGQLISSAGQTQNIDTTSLASLTAGNVAAMGGLAKLIGENEFPNQFHEGAKDSLYMTIVGSRVVLVVIFDNRTSLGLVRLRIKKASDELTKIFESLVKKTDSPGAGSPFAEISDDDIDNLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB29</accession>
    <name>Q1DB29_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CdiA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ABF91469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF91469">
        <property type="protein sequence ID" value="ABF91469"/>
        <property type="gene ID" value="MXAN_1899"/>
    </dbReference>
    <dbReference type="GeneID" id="41359314"/>
    <dbReference type="KEGG" id="mxa:MXAN_1899"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="YWERFRY"/>
    <dbReference type="OrthoDB" id="626860at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:tRNA-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CDI_toxin_Bp1026b_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDI_toxin_Bp1026b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040559">
        <property type="entry name" value="CdiA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18451">
        <property type="entry name" value="CdiA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="491"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="574" mass="61590" checksum="46C62515EA21C7A1" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DB50</accession>
    <name>Q1DB50_MYXXD</name>
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        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551979.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1877"/>
    <dbReference type="EnsemblBacteria" id="ABF88338">
        <property type="protein sequence ID" value="ABF88338"/>
        <property type="gene ID" value="MXAN_1877"/>
    </dbReference>
    <dbReference type="GeneID" id="41359292"/>
    <dbReference type="KEGG" id="mxa:MXAN_1877"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705779_0_0_7"/>
    <dbReference type="OMA" id="LCGWCDH"/>
    <dbReference type="OrthoDB" id="506998at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="391" mass="44397" checksum="640EE9E47956D61A" modified="2006-07-11" version="1">MSALRNQHLSYSRLSRFEACPLSYQLHYLDKRTAEPGVPLSFGKALHAVLERLLQEVIDTEYVGRLSEERALQLYREEWAASGLSGLDVFQQGLRILQDFVRQQGRVDCRDILAVEKEFRLPVGPFTVLGFIDRVDWVDDETVHVMDYKSNHQLFTREELDSSLQLSLYALAARRMWPWAKKVRLSMWMLRHGVLQETTRTEEQLEAALAYVETLGQQMETAESFPARLNPNCVYCDHRRDCPAYAQALEGRRGVVCEDTSDLESVARERQEVAHLAKILGARKAELEGVLRAHLAEQDELVLAGTRYRMFNTTSLDYPLEPTVAVLAPATGLPREDLVQRLASVEKKALDALLKDAGKRLGTARVALLKAELDSLAAKHHSPRFWAKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD5</accession>
    <name>Q1DBD5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_1790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551897.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1790"/>
    <dbReference type="EnsemblBacteria" id="ABF87657">
        <property type="protein sequence ID" value="ABF87657"/>
        <property type="gene ID" value="MXAN_1790"/>
    </dbReference>
    <dbReference type="GeneID" id="41359211"/>
    <dbReference type="KEGG" id="mxa:MXAN_1790"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388783_0_0_7"/>
    <dbReference type="OMA" id="SHWVMWE"/>
    <dbReference type="OrthoDB" id="94746at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="504"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="538"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF87657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="703" mass="76817" checksum="D180886D3E965A61" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBV5</accession>
    <name>Q1DBV5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1616"/>
    <dbReference type="EnsemblBacteria" id="ABF85912">
        <property type="protein sequence ID" value="ABF85912"/>
        <property type="gene ID" value="MXAN_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1616"/>
    <dbReference type="HOGENOM" id="CLU_1293676_0_0_7"/>
    <dbReference type="OMA" id="WLSAEAW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF85912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="29742" checksum="CBAE786EB49B0A04" modified="2006-07-11" version="1">MGRRGASQATRARLPCEQDARCLRIRCMLRARRWAAGTRPPGPGRRRHGRTRMSGQSLAAKMLEGAREWAKRLPNALSNDMAVDVSRRRVRLSHARVETVVSQLLARLKNFELREWSSRENVYDIRFSVHGWKLRVETALERVELASGRYRLWLKTPGVVALEESRTASSLMMGVLRAGAGRAAMRVLAERLLPPGIRWDGQVLQVEGPLPEEGVLPARLFDSASLAMTAEHQSEGLWLAAEAWPGLMDLLQVVFGTELPRTPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCD5</accession>
    <name>Q1DCD5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease III</fullName>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">nth</name>
        <name evidence="12" type="ORF">MXAN_1431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1431"/>
    <dbReference type="EnsemblBacteria" id="ABF88492">
        <property type="protein sequence ID" value="ABF88492"/>
        <property type="gene ID" value="MXAN_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1431"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_7"/>
    <dbReference type="OMA" id="WQQFTHL"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="46"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF88492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="238" mass="26151" checksum="B8A016AA3C2C2602" modified="2006-07-11" version="1">MPGRETVAEKRKRALLVMDRLAADMPDARIELDYRTPLELLVAVILSAQCTDKRVNMVTPALFQRFSDAQAYAEAEPSDVEPFIRTCGLYRAKAKNIVAAARSLVQEHAGQVPLKRDALEKLPGVGRKTAGVVCIHLGGDVAFPVDTHVKRLAYRLGFTTKADPDKVEADMQAVLPSERWALGHQLLVWHGRRTCFARSPACERCVVADLCPKKGVKVQKDAGATETPARSPRARAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCF6</accession>
    <name>Q1DCF6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88326">
        <property type="protein sequence ID" value="ABF88326"/>
        <property type="gene ID" value="MXAN_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1410"/>
    <dbReference type="HOGENOM" id="CLU_729223_0_0_7"/>
    <dbReference type="OMA" id="PVNFATE"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="36218" checksum="8BA1A6D9C06291AF" modified="2006-07-11" version="1">MAPLAPREPLQPIPAVRRGYADESEFQAEVDDLDTSLAAHAPMLAGVDAANAEAPEHLRVFAGESSFEAAPPRYSQLLGSQLPAALGAPREPVSGAAHRPSFRGASAQDMGSDLLSPEAAAWELQNRDTSTAPTPMEAEDVLFMLNGPGAAADLEPPLELGLEDIFEEAPRLHAAEDALFMAGADDASAASSDTTEIQQPSLAAARSGAPVNFATEAAGIDAVPADMMTAAAGDARVDDAPAGYALGSAYAATYGQQFAVRQALDPAVSPAGPDEFLADPNDLNMLLPEEPSLDDAAVAGVLGSISANPAAASAPVAAAFASQGVEVVAEALEPELRPEANPSITEAPAPENPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD29</accession>
    <name>Q1DD29_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_1185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551304.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1185"/>
    <dbReference type="EnsemblBacteria" id="ABF88214">
        <property type="protein sequence ID" value="ABF88214"/>
        <property type="gene ID" value="MXAN_1185"/>
    </dbReference>
    <dbReference type="GeneID" id="41358635"/>
    <dbReference type="KEGG" id="mxa:MXAN_1185"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_11_0_7"/>
    <dbReference type="OMA" id="EAYPMVQ"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="785" mass="87914" checksum="3D1947F792F111EC" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DD95</accession>
    <name>Q1DD95_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2379 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551238.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90483">
        <property type="protein sequence ID" value="ABF90483"/>
        <property type="gene ID" value="MXAN_1118"/>
    </dbReference>
    <dbReference type="GeneID" id="41358570"/>
    <dbReference type="KEGG" id="mxa:MXAN_1118"/>
    <dbReference type="eggNOG" id="ENOG5031GSH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161985_0_0_7"/>
    <dbReference type="OMA" id="IDWDPVR"/>
    <dbReference type="OrthoDB" id="1970638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011753">
        <property type="entry name" value="DUSAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09543">
        <property type="entry name" value="DUF2379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02267">
        <property type="entry name" value="TIGR02267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2379" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="122" mass="13338" checksum="A713758400B713C7" modified="2006-07-11" version="1">MAESIDWDPVRELARRVEAGEALSLTAEVRALLLRSAREVGIPEEDAHAAVAGVATATALLHETRRRIRDGSQRLMRALTGARRLRDAGDAAGARALLEDVLAVEQVPLYREQAELALEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDE1</accession>
    <name>Q1DDE1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase cytochrome b558 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhC</name>
        <name evidence="8" type="ORF">MXAN_1072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551192.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1072"/>
    <dbReference type="EnsemblBacteria" id="ABF91908">
        <property type="protein sequence ID" value="ABF91908"/>
        <property type="gene ID" value="MXAN_1072"/>
    </dbReference>
    <dbReference type="GeneID" id="41358523"/>
    <dbReference type="KEGG" id="mxa:MXAN_1072"/>
    <dbReference type="eggNOG" id="COG2009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078991_0_0_7"/>
    <dbReference type="OMA" id="YDMMANI"/>
    <dbReference type="OrthoDB" id="750409at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF91908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="226" mass="24993" checksum="569C404146400EEE" modified="2006-07-11" version="1">MSTQAAAAVETKTPLLKSRLGSFLAVVPLSIWVINHLWDNLSAFNGADAWQKSVTTYANPFSQVFTFLIVLLPLLMHTGWGLVRLFSFRPNNARYNNYGNLKYILQRITAVGVLAFLGAHIWLAFLYPRLVLGHPEAFDDIAREMHHHAPTLVVYLLGTLGTSYHLANGLQGFAMGWGLLSSERSMRKFEPVVIILFLVLTAMSWAVIYALYTAGAAFSPVGATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDL9</accession>
    <name>Q1DDL9_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">MXAN_0993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551114.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0993"/>
    <dbReference type="EnsemblBacteria" id="ABF86976">
        <property type="protein sequence ID" value="ABF86976"/>
        <property type="gene ID" value="MXAN_0993"/>
    </dbReference>
    <dbReference type="GeneID" id="41358449"/>
    <dbReference type="KEGG" id="mxa:MXAN_0993"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="LWIAFSD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="271"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABF86976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="486" mass="52594" checksum="B39833CEEAA126FF" modified="2006-07-11" version="1">MPPTSALILNVNDDAASRYVTSRVLGLAGFRVVDAASGMEALALVTEDTDLVILDVRLPDTSGLEVCRRLKETPRTQGVLVLHLSAQAVGPGDRAQGLEHGADGYLVAPVDPEELVAQVHALLRLRQAEREVKALSREVVHQRQLLELAISCAADPIALYDEAGRVLSANQSLYASRGSHAVHAPGRTLDEMQAADGALTPYLEQVRVALRTGQVQRGTMVLGSDRGPRYFDYVLSPALGAGGEVLAVMSSLRDVTESRSAEEFREQFIGMLGHDLRNPLNALSMSAQQLRRKGGLDERQGMLTERILTSAERMDRMIRQLLDFARSRLGGGIPVVRSSCDVFEVVRRTVDELRASHPGRVVELESKGDGLGKWDFDRLEQAVGNLVANALKYSPAESTVRVGAEGSEREVVLRVHNRGTPIPAEDLPHVFGAWRRGRRAASDAGAPSGLGLGLDITRQIVRAHDGDAQVASSATEGTTFLIRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDN7</accession>
    <name>Q1DDN7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551096.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0975"/>
    <dbReference type="EnsemblBacteria" id="ABF88637">
        <property type="protein sequence ID" value="ABF88637"/>
        <property type="gene ID" value="MXAN_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="41358431"/>
    <dbReference type="KEGG" id="mxa:MXAN_0975"/>
    <dbReference type="eggNOG" id="COG3860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849465_0_0_7"/>
    <dbReference type="OMA" id="HECKVRA"/>
    <dbReference type="OrthoDB" id="1975201at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="316" mass="34871" checksum="BF61E50F8CCBBCFB" modified="2006-07-11" version="1">MRADAKGLFMRTVVTLHECKVRASLLLKELASADASRAAQAAERLRVLPGFAGLALGEVLARKETVQHKHALTVIAREQGHATWGELKQVRELDFEHLLAPVGGSHLNRWFSSYAEAADSLRTQGGFLFPFREQFFVCEASLVEALGVDPEDADWSLMGRDWMAPKDGAAQARLAQRFALHSPSHASTSPDTRSPMSAGSRRSELKRAYREAPPPMGVYAVRCLANGKVLVGASANVQGMLNRIRFELSTGMDRLPTLLEDWKRYGAEQFTFEVLDVLKPSDEPVVAPEEELKVLEALWLDRLKPYGDAGYNVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT1</accession>
    <name>Q1DDT1_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_0931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551052.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0931"/>
    <dbReference type="EnsemblBacteria" id="ABF92200">
        <property type="protein sequence ID" value="ABF92200"/>
        <property type="gene ID" value="MXAN_0931"/>
    </dbReference>
    <dbReference type="GeneID" id="41358390"/>
    <dbReference type="KEGG" id="mxa:MXAN_0931"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368708_0_0_7"/>
    <dbReference type="OMA" id="MVQFRDI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="275"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="413"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="657"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF92200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="777" mass="84273" checksum="C631BB6D9C7881D7" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDT7</accession>
    <name>Q1DDT7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4-oxalocrotonate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551046.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0925"/>
    <dbReference type="EnsemblBacteria" id="ABF91299">
        <property type="protein sequence ID" value="ABF91299"/>
        <property type="gene ID" value="MXAN_0925"/>
    </dbReference>
    <dbReference type="GeneID" id="41358384"/>
    <dbReference type="KEGG" id="mxa:MXAN_0925"/>
    <dbReference type="eggNOG" id="COG3971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060136_4_0_7"/>
    <dbReference type="OMA" id="MLGVYQP"/>
    <dbReference type="OrthoDB" id="1314120at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="261" mass="28117" checksum="8562E13FC522FA9A" modified="2006-07-11" version="1">MTATVDHEALAHFLDSARLERREVAPLTREQPALSVPDAYAIQEAGIRLRLSHGERVVGLKMGLTSEAKRKQMNLDSPVYGVLTDRMQVPAGGVIQLSQGVHPKIEPEIAFRTARELRGTVTRDEVLDACESVFAAMEILDSRYRDFKYFSLPDVVADNASSSLFVLGTAEHPPRAMDLTRLEMTLSVNGEPVQSARADAISGDPVVSVIQLCELLAQRGQVLPAGSIVLAGAATAAHMLRPGDRVQLTVEGLGIVAVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DDU8</accession>
    <name>Q1DDU8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551035.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93027">
        <property type="protein sequence ID" value="ABF93027"/>
        <property type="gene ID" value="MXAN_0914"/>
    </dbReference>
    <dbReference type="GeneID" id="41358373"/>
    <dbReference type="KEGG" id="mxa:MXAN_0914"/>
    <dbReference type="HOGENOM" id="CLU_852123_0_0_7"/>
    <dbReference type="OMA" id="ERFADPI"/>
    <dbReference type="OrthoDB" id="1962806at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF93027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="32882" checksum="C429A784E295C540" modified="2006-07-11" version="1">MWGVGIVYLLVYILGSALVTMGLSRGIQAVFEGSPVGAAVPTLLYGVGAIGLAGLLHVLAIRRQLKEGKPSVMPQMKRHLIWGCAAMWAGPLLAGWVQFELFRDPIVMFSQSTLVGGILMTFGVCSQLMVRWRMPWVGTMVTVALVGLPLGWLSSDLLIAHFNHHLTTVVVPLRKEVGGEPRSSVYERDFPDMPLLPRESFDSQLELLAALSEAKAVNFDEEVAAGRMRKLDDGSYVRVASDGEESAVEVADMKKLMEDVRETDARRVAEAHAAEMAAWEEDYRRRKQGGRLFTRAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE62</accession>
    <name>Q1DE62_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0798"/>
    <dbReference type="EnsemblBacteria" id="ABF88329">
        <property type="protein sequence ID" value="ABF88329"/>
        <property type="gene ID" value="MXAN_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0798"/>
    <dbReference type="HOGENOM" id="CLU_1303809_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="211" mass="23634" checksum="FC747158EF0FDEF3" modified="2006-07-11" version="1">MGRRASGPSSPRPHGHPPARERATPTWRVRGRDTTFRKRISPERDRPREERDTPMWSPSPRRVRPAPWRVRGGTRASARPLAAPPATSRPLDTHAPPRPYRGRPHGVSSMACGLSLTALGGAGIQVLGPSCLERLRRRKRGLHRWWHRSQEPLMESMETALTMALLGVSVLPLVGDDNPPEEWTARPDAVRDIRDDAPDDDLDFESAFASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DE79</accession>
    <name>Q1DE79_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF85899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0778"/>
    <dbReference type="EnsemblBacteria" id="ABF85899">
        <property type="protein sequence ID" value="ABF85899"/>
        <property type="gene ID" value="MXAN_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0778"/>
    <dbReference type="HOGENOM" id="CLU_3063773_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF85899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="53" mass="6006" checksum="5DB70D914543437D" modified="2006-07-11" version="1">MMTSLLYLTKRQTQLPEALPVESFSVGATALLVLASLRLSRRAIKLERQELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEI9</accession>
    <name>Q1DEI9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_0666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550797.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0666"/>
    <dbReference type="EnsemblBacteria" id="ABF87396">
        <property type="protein sequence ID" value="ABF87396"/>
        <property type="gene ID" value="MXAN_0666"/>
    </dbReference>
    <dbReference type="GeneID" id="41358141"/>
    <dbReference type="KEGG" id="mxa:MXAN_0666"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_7"/>
    <dbReference type="OMA" id="ACAPKPE"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188450" evidence="2">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="78"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="369" mass="38219" checksum="193583DFC4E50670" modified="2006-07-11" version="1">MKPNLKPSAVRVFAAAGMATAVLSLTACQKADASSSPPAKGSAQEVVPTVKVVSARTVRAAPSESVTGTLFPAQGLMVGFEVGGRLSVVRVKKGQGVKKGDVLAQLDPEIADAQVAQAEAAVAAAEAASTMAADVAARNEKLQQQGGVSEVAHRTASANAAQAQAQWMAAKAQLAQARASRRRHDLRAPFDGTLIDAPEQTGATVAPGTPLFNLERLDTLLLKTTVSEALRSQLEPGAKVRVESVGARVSSDEAVVRTILPSADPATRRIPVELAVPNADGRFVAHTLARAVLSLGQVQDAQVLPGTALSALNGDHVWVVASGQVRRVDVRVLERREQGEVVVLASSPLDSVVDHPTPGLSQGARVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEL6</accession>
    <name>Q1DEL6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550770.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0639"/>
    <dbReference type="EnsemblBacteria" id="ABF91215">
        <property type="protein sequence ID" value="ABF91215"/>
        <property type="gene ID" value="MXAN_0639"/>
    </dbReference>
    <dbReference type="GeneID" id="41358117"/>
    <dbReference type="KEGG" id="mxa:MXAN_0639"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_85_1_7"/>
    <dbReference type="OMA" id="RFNYSAM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="528"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="784" mass="85043" checksum="1D148F48D33DA676" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DEX4</accession>
    <name>Q1DEX4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550662.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0530"/>
    <dbReference type="EnsemblBacteria" id="ABF90732">
        <property type="protein sequence ID" value="ABF90732"/>
        <property type="gene ID" value="MXAN_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="41358013"/>
    <dbReference type="KEGG" id="mxa:MXAN_0530"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099777_1_1_7"/>
    <dbReference type="OMA" id="GWFIDYT"/>
    <dbReference type="OrthoDB" id="1489088at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188471" evidence="2">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="26490" checksum="ECA7A580498ED05F" modified="2006-07-11" version="1">MMTRSGRRMTSLWLAGCLAFAGCSKKEEPTAAPTGAQPQPEVQAPPTSPPLGTIPREGEAAAKPPVHTASMGDEEVAGAPPSETEPPSDAPTGDAPAEDPKNREWTTTPVSMKRRPAQSVTLRSVRAGTHADFDRVVFEFDGPQVPGYQLQYVDKPIIQCGSGDETPLAGKGFLQVMLTPARGHDDQGRATVAALEMKPKLPTLLELVRTCDFEAEVTWVLGNKAPTDFRVMELRDPTRLVVDVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DF29</accession>
    <name>Q1DF29_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0474"/>
    <dbReference type="EnsemblBacteria" id="ABF89257">
        <property type="protein sequence ID" value="ABF89257"/>
        <property type="gene ID" value="MXAN_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0474"/>
    <dbReference type="HOGENOM" id="CLU_1729422_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="151" mass="15342" checksum="64BDCE8B7FD15198" modified="2006-07-11" version="1">MGAWAPASSSSWAWSSCAAHTGRPGCRPARRRPPRSRAPPPDARPGGAQGAWDAAAWTMTPGPWARMPSPSLSSTVTMMAKVVVSDTSGATHVGLRAFASLKVPAGSAGSCCHWKVMASPSGSSTSKTKDTTPPAPTTCGEGRGPVETLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFE9</accession>
    <name>Q1DFE9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0350"/>
    <dbReference type="EnsemblBacteria" id="ABF89433">
        <property type="protein sequence ID" value="ABF89433"/>
        <property type="gene ID" value="MXAN_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_0350"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ABF89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="540" mass="57513" checksum="1DAEE3C25A679748" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DFY5</accession>
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        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
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    </dbReference>
    <dbReference type="Pfam" id="PF00892">
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    </dbReference>
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        <location>
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            <end position="60"/>
        </location>
    </feature>
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        <location>
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            <end position="92"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="140"/>
        </location>
    </feature>
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        <location>
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            <end position="167"/>
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    </feature>
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            <begin position="149"/>
            <end position="280"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="30861" checksum="21CA6A678027AD0C" modified="2006-07-11" version="1">MSRVLTKPGPVTVAVLTLLVAMASIQTGASLAKQVFPVLGAAGATALRVFFAALILAAVFRPWRQRLTRKDLRAVAIYGAALGGMNLTFYLALERIPLGIAVAIEFTGPLALAIFSTRRALDFVWALLAVAGILLILPLSETSRSLDWMGVFWALVAATCWALYILFGQRAGGTVHGGTAASLGMCVAALLVMPFGVAHAGMKLLDVSLLPIILCVAVLSSALPYSLEMYALKALPTRTFGILMSLEPALAAVSGLLLLDERLSLVQWAAIGCIILASVGSSATSRKPVEAVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG05</accession>
    <name>Q1DG05_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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    </organism>
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        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0135"/>
    <dbReference type="EnsemblBacteria" id="ABF87680">
        <property type="protein sequence ID" value="ABF87680"/>
        <property type="gene ID" value="MXAN_0135"/>
    </dbReference>
    <dbReference type="GeneID" id="41357638"/>
    <dbReference type="KEGG" id="mxa:MXAN_0135"/>
    <dbReference type="eggNOG" id="ENOG50348BU">
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    </dbReference>
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    <dbReference type="OMA" id="AILMFHP"/>
    <dbReference type="OrthoDB" id="1492034at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="217" mass="23000" checksum="CC64C5E44804C68F" modified="2006-07-11" version="1">MRPQSPAPKRRVDSDGVTHITPARTGKGLGVWLVGGACVFTLACIGLSVWWGSTDIKVEAPPPLAEVPLPIPPPTSEVRARAPRTRPPPVAASAPQPAPEPVAELATDTDVQEPAMDSELTGMQLYRPGTKPIKKGLVVPDDFELPPGYVRHFQYKDSGEIVAAVLMFHPDHQPVDANGQPIPKPADGLVPEELAPPGMPIQRLELPEGAESGAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG10</accession>
    <name>Q1DG10_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Deltaproteobacteria</taxon>
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            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0130"/>
    <dbReference type="EnsemblBacteria" id="ABF92599">
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    </dbReference>
    <dbReference type="GeneID" id="41357634"/>
    <dbReference type="KEGG" id="mxa:MXAN_0130"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021655">
        <property type="entry name" value="Put_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11617">
        <property type="entry name" value="Cu-binding_MopE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188525" evidence="1">
        <location>
            <begin position="20"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="617" mass="64195" checksum="81987A1DE1055644" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DG63</accession>
    <name>Q1DG63_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_0077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
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                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011550224.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_0077"/>
    <dbReference type="EnsemblBacteria" id="ABF87038">
        <property type="protein sequence ID" value="ABF87038"/>
        <property type="gene ID" value="MXAN_0077"/>
    </dbReference>
    <dbReference type="GeneID" id="41357584"/>
    <dbReference type="KEGG" id="mxa:MXAN_0077"/>
    <dbReference type="HOGENOM" id="CLU_727064_0_0_7"/>
    <dbReference type="OrthoDB" id="746412at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="388" mass="39998" checksum="D9AFC4694DF81121" modified="2006-07-11" version="1">MALACGIADRGGGLWCAGDAGGPPPPAAEQETLRAAEEQAALLSPPAGCTEITMGELTNGVERTPVQYGSQPTYVGSFSDQGDPALADVARIRLDVNTAPGVYDLATGGTNLFTCEQCVWGVQDAGTSTAKTFVAESGTLLLALKLTPQQTIGALANVTLRQSVAAPPLYAPYTGTEPVAGGECRWIRFATWNTARNGGCDPREGSLTANIPGHTCVATNRAADDGTLERSLGTKTHGEACTYTAPTSEYELAATDCAEGYACTTAWGSSSTCMATCDFMAAEPGCPTGTVCGVQGLCQEQAVQVASGFDFDPALIGEECTLGYAEFCGAEGARGVCLDLNGTGRGTCFPYTRARSDCGPGEELGYVSYPLAGGGYDRTYGFCYPDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CVQ0</accession>
    <name>Q1CVQ0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_7417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557328.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7417"/>
    <dbReference type="TCDB" id="1.B.18.3.9">
        <property type="family name" value="the outer membrane auxiliary (oma) protein family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88970">
        <property type="protein sequence ID" value="ABF88970"/>
        <property type="gene ID" value="MXAN_7417"/>
    </dbReference>
    <dbReference type="GeneID" id="41364573"/>
    <dbReference type="KEGG" id="mxa:MXAN_7417"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_3_2_7"/>
    <dbReference type="OMA" id="GEPEMTM"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="219" mass="24481" checksum="0D4432DE24628285" modified="2006-07-11" version="1">MRRVPPLMPSTHRQPPSAPRRPWRSFACAALLLLAPACRGLGKYTWVDDYQEKPPPVDSAYRIAAGDLLNIRVWNQESLTTQARVREDGRISLLFLDDVEAAGHTPALLSQQIQTRLKDYINHPVVTVALEMARPIKVTMVGEVNRIGPLEIDPGASLLQALAGAGGFTEYAHKDRIFVMRQEEGAAPERIRFRYDDLIHAEGRAPTFRLRPGDVVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CWC3</accession>
    <name>Q1CWC3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_7187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF93069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011557106.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_7187"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF93069">
        <property type="protein sequence ID" value="ABF93069"/>
        <property type="gene ID" value="MXAN_7187"/>
    </dbReference>
    <dbReference type="GeneID" id="41364360"/>
    <dbReference type="KEGG" id="mxa:MXAN_7187"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_7"/>
    <dbReference type="OMA" id="QPSLWEG"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF93069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="42543" checksum="77086E82BAD16017" modified="2006-07-11" version="1">MSDSPRVLLIAERFPPDIGGLARSGARTAGSLVKLGARVDVLAWTRTAAPGALQTVEDAGDVSPFARGVTLHRLGLFGSTDLSMQHTLDVLGYLHAKQRYDLVWGHYLSPPGFLAVAFAESVGIASTVSARGNDVDQLMFPPGDFARLLWTLQRARVLTAASADLGRKMCMLLGRDETVEVIPNAVDTGIFSPGPADPALRERLGIAPDEAVLGFSGELRHKKGLPFLLSALTEVRRVRPACLLVIGEVRPRDAEHLVAFRAEHPEDAARILISGPLDTPEAIAAHLRLCDVYLQPSLWEGMPNALLEAMACARPVIASDAGGIPEAVDAGRNGFIVSKALLNHLGQACLDVLSLPLEQRAAMGAAARQRIEERFQAHAEAEVLRRVLARAIPSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXI9</accession>
    <name>Q1CXI9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_6766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556692.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6766"/>
    <dbReference type="EnsemblBacteria" id="ABF90015">
        <property type="protein sequence ID" value="ABF90015"/>
        <property type="gene ID" value="MXAN_6766"/>
    </dbReference>
    <dbReference type="GeneID" id="41363957"/>
    <dbReference type="KEGG" id="mxa:MXAN_6766"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_0_0_7"/>
    <dbReference type="OMA" id="PQSFHWT"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="761"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="286"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="480"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="745"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="846" mass="89195" checksum="43A9F33B7F21A060" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CXP9</accession>
    <name>Q1CXP9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556632.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6707"/>
    <dbReference type="EnsemblBacteria" id="ABF92989">
        <property type="protein sequence ID" value="ABF92989"/>
        <property type="gene ID" value="MXAN_6707"/>
    </dbReference>
    <dbReference type="GeneID" id="41363900"/>
    <dbReference type="KEGG" id="mxa:MXAN_6707"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_2_0_7"/>
    <dbReference type="OMA" id="GGICHKR"/>
    <dbReference type="OrthoDB" id="1864858at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF92989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="129" mass="13576" checksum="44FCBCD13E3A7E2E" modified="2006-07-11" version="1">MKKPAVGSVGWMDLTVKDAVAVRDFYKDVAGWSATGLDMGGYEDFVMMPPGGGETPAGGICHARGKNADIPSGWMMYITVADLEQSLERVTAMGGRVLGTIRGSAKTGRFCFIEDPSGTACALYQSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CYB5</accession>
    <name>Q1CYB5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_6486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556416.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88186">
        <property type="protein sequence ID" value="ABF88186"/>
        <property type="gene ID" value="MXAN_6486"/>
    </dbReference>
    <dbReference type="GeneID" id="41363693"/>
    <dbReference type="KEGG" id="mxa:MXAN_6486"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_7"/>
    <dbReference type="OMA" id="ARYHEEY"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="163" mass="17865" checksum="87B4D8C641CF17F2" modified="2006-07-11" version="1">MRGMNGSGEQLERKTKPGSGPGQAGPAGDLPRQAWTLLFELMHTHMRNFPALAAEFDLSPVQAHVLRQLGEGPLAMSTLAAYLSCDASNVTGLVDRMEARGLVVRRSSEQDRRVKMLVLTEDGAALRERLLERIFEPPDAICGLPEEDLCALRDIMRRALGAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZ49</accession>
    <name>BSHC_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative cysteine ligase BshC</fullName>
            <ecNumber evidence="1">6.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bshC</name>
        <name type="ordered locus">MXAN_6193</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BshC family.</text>
    </comment>
    <dbReference type="EC" id="6.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1CZ49"/>
    <dbReference type="SMR" id="Q1CZ49"/>
    <dbReference type="STRING" id="246197.MXAN_6193"/>
    <dbReference type="EnsemblBacteria" id="ABF92811">
        <property type="protein sequence ID" value="ABF92811"/>
        <property type="gene ID" value="MXAN_6193"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_6193"/>
    <dbReference type="eggNOG" id="COG4365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022249_1_0_7"/>
    <dbReference type="OMA" id="TTGHQLN"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01867">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011199">
        <property type="entry name" value="Bacillithiol_biosynth_BshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10079">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03998">
        <property type="entry name" value="thiol_BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000378243" description="Putative cysteine ligase BshC">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01867"/>
        </source>
    </evidence>
    <sequence length="557" mass="60646" checksum="F1A74471D7F0CC91" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZG1</accession>
    <name>Q1CZG1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_6077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011556026.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_6077"/>
    <dbReference type="EnsemblBacteria" id="ABF89381">
        <property type="protein sequence ID" value="ABF89381"/>
        <property type="gene ID" value="MXAN_6077"/>
    </dbReference>
    <dbReference type="GeneID" id="41363313"/>
    <dbReference type="KEGG" id="mxa:MXAN_6077"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1895370_0_0_7"/>
    <dbReference type="OMA" id="KCLHCNA"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH_5" evidence="1">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="121" mass="13825" checksum="C9B79547832BD786" modified="2006-07-11" version="1">MSQAKRRKILGIIETDNTFERANHRDREAWLGKCLHCNAHLWVGLDGEPISRATIEHILPKTAGGTEALTNLGLACARCNQGKGTRHDARYHRDARARELVERLLARRLAHWRKPETDEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZQ5</accession>
    <name>Q1CZQ5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555932.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5983"/>
    <dbReference type="EnsemblBacteria" id="ABF86837">
        <property type="protein sequence ID" value="ABF86837"/>
        <property type="gene ID" value="MXAN_5983"/>
    </dbReference>
    <dbReference type="GeneID" id="41363222"/>
    <dbReference type="KEGG" id="mxa:MXAN_5983"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_1_2_7"/>
    <dbReference type="OMA" id="RGMRPDG"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="213" mass="23265" checksum="C537A90B9F9AE182" modified="2006-07-11" version="1">MPKFTLVPPEIEAYADAHTTAPAPLFDELRDVTYARMSSPNMQVGSVEGTFLRMLVALTGARRVLEIGTFTGYSALMMAEALPDDGALITCDIDPEATDVARAFFLRSPHGRKIDLRMGPALDTLKTLQGPFDLAFIDADKPSYAAYWDAVLPLLRPGGLIIADNVLWSGRVLQPEGPSDHAIVDFNAKVAADPRVEHVLLTVRDGMMLARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZS6</accession>
    <name>Q1CZS6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555911.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5960"/>
    <dbReference type="EnsemblBacteria" id="ABF91975">
        <property type="protein sequence ID" value="ABF91975"/>
        <property type="gene ID" value="MXAN_5960"/>
    </dbReference>
    <dbReference type="GeneID" id="41363199"/>
    <dbReference type="KEGG" id="mxa:MXAN_5960"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052920_1_2_7"/>
    <dbReference type="OMA" id="KNARVYP"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="319" mass="35553" checksum="42B3E44581340BEC" modified="2006-07-11" version="1">MAWFYLGTPMPLATESLTPSQLRELEQVDARHVPRLAVFLMLYLGAAALSVVLAARDTAWTDWLARAPLYLIAAASLHGISLFTHEAVHGGLARRPWLNRLGGIACALPVLQNYAAYKVLHLKHHADLGGGKDPDHYANYTGRRWLELLMHVGRLLLGYPAYITMIPILGWRQGTTAERRWVLFEVALAVAGLTAAVIFIPGQVLLHAWAIPMLLLNTLVNVRGMSQHTFLPESTHPVRGSRTILSNPVTRFFMCNENYHLEHHLYPRVPWYNLPELHRTLRADLVAQGAPFIPSYFSFVRGVLSGSLIRGAKPATPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZT3</accession>
    <name>Q1CZT3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like superfamily domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555904.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5953"/>
    <dbReference type="EnsemblBacteria" id="ABF86144">
        <property type="protein sequence ID" value="ABF86144"/>
        <property type="gene ID" value="MXAN_5953"/>
    </dbReference>
    <dbReference type="GeneID" id="41363192"/>
    <dbReference type="KEGG" id="mxa:MXAN_5953"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040402_0_0_7"/>
    <dbReference type="OMA" id="LYHSWAE"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188076" evidence="2">
        <location>
            <begin position="41"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="415"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="512" mass="55607" checksum="B5039D3462399A73" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZV8</accession>
    <name>Q1CZV8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">MXAN_5928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555879.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5928"/>
    <dbReference type="EnsemblBacteria" id="ABF90709">
        <property type="protein sequence ID" value="ABF90709"/>
        <property type="gene ID" value="MXAN_5928"/>
    </dbReference>
    <dbReference type="GeneID" id="41363166"/>
    <dbReference type="KEGG" id="mxa:MXAN_5928"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_0_7"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="295" mass="31485" checksum="B9DD265F28806E03" modified="2006-07-11" version="1">MKTFEGSMTALATPFRNGALDEPAYRALVRQQIEGGTSVLVPMGTTGEAVTMTADERARAVKVVVEEAKGRVTVVGGAGSNSTAETIDGVRRVRDAGADGTLIVTPYYNKPTQEGLLEHYRAVAKAHPGFPIIAYNVPGRTGVDLLPDTVLRLCDIPEVVALKEATGSMPRAIDILEKCGDRMTLLSGDDFTVLPFIACGGKGVISVSSNVAPRMMADLVAAARAGNIAVARDLQVRMNELHRLLFIESNPTPVKWGLHVMGLFGPEVRLPLVQMTEPNAAKLRDTLRQLGLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1CZW3</accession>
    <name>Q1CZW3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GutQ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gutQ</name>
        <name evidence="9" type="ORF">MXAN_5923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555874.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5923"/>
    <dbReference type="EnsemblBacteria" id="ABF92349">
        <property type="protein sequence ID" value="ABF92349"/>
        <property type="gene ID" value="MXAN_5923"/>
    </dbReference>
    <dbReference type="GeneID" id="41363161"/>
    <dbReference type="KEGG" id="mxa:MXAN_5923"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_13_1_7"/>
    <dbReference type="OMA" id="LMACLMR"/>
    <dbReference type="OrthoDB" id="571638at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="63"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABF92349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="352" mass="37027" checksum="D13C8B909582B8FE" modified="2006-07-11" version="1">MARPSRSAAKKPRLRALPGRPAQPPAVLPDAEATLAYARSVLEAEARAILGVTERLGDDFLRAVQLVRDCRGQVIVTGMGKAGHIGQKLSATLASTGIRSVYLHPAEAVHGDLGRVGRGDVILALSNSGSTEELIRLLPSFKRMETPVIALTGDAKSPLGRGADVVLDIGAIAEACPMGLVPTASTAALHAIGDALAMTVLRSRPFGTEDYALLHPGGKLGRSVQRVFELMRTGNANPLVRDTSPLSAVVGVMTKTPGRPGAACVVDKAGKLVGIFTDGDLRRRVEAGLTDFTVPVRELMGKNPRCVTPETLVLAAATQMRELRVDQLPVVDVEGRAVGLLDVQDLLAAKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D045</accession>
    <name>Q1D045_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555792.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5841"/>
    <dbReference type="EnsemblBacteria" id="ABF90303">
        <property type="protein sequence ID" value="ABF90303"/>
        <property type="gene ID" value="MXAN_5841"/>
    </dbReference>
    <dbReference type="GeneID" id="41363079"/>
    <dbReference type="KEGG" id="mxa:MXAN_5841"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_7"/>
    <dbReference type="OMA" id="QYVAHVE"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="PTHR43149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF90303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="275" mass="29963" checksum="75714DD9F074F365" modified="2006-07-11" version="1">MDGTYKSLRIEKNEGVAELVLTGPGKGNAMGPDFWREMPEAIRALDADDSVRVVLVRGEGKHFTFGLDLMGMMESLGPLLTGESNLALERLKLLSLIGDMQQATEGMARCRKPVIAAVHGWCIGGGMDLIAACDFRYCSQDAKFSLREVKVGIVADLGALQRLPRIIGEGHTRELAYTGGDVDAARALRMGLVNEVFPTPEALLEEARATAKRIAENAPLVVQGAKQVMEYCADKSIADGLRYVAVWNSAFLQSHDLAEAFSAFVERRPPHFQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0Q6</accession>
    <name>Q1D0Q6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555582.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5628"/>
    <dbReference type="EnsemblBacteria" id="ABF90879">
        <property type="protein sequence ID" value="ABF90879"/>
        <property type="gene ID" value="MXAN_5628"/>
    </dbReference>
    <dbReference type="GeneID" id="41362874"/>
    <dbReference type="KEGG" id="mxa:MXAN_5628"/>
    <dbReference type="HOGENOM" id="CLU_098625_0_0_7"/>
    <dbReference type="OMA" id="HTSFRIP"/>
    <dbReference type="OrthoDB" id="1551205at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="246" mass="26208" checksum="146ECC9A9C5F65EA" modified="2006-07-11" version="1">MTPCMRAPARSRCALAVVVAGATCHRTTPDLPSGRSSEVGWREAGEGSSTPREGHMRRWTGLLAVAALCGAACDGKKSTDRPTRAELRKTGGATVEVIPSDGQLPYCMLYTVSEKGVIRQLTLTRENRSIRCDANKPVAHTSFRIPVQEGKVRMYIFFSDDRIPAGPVAQQLYELRSQERINAMDLRLPGRVFVETLEFTPEEGGTPVTGTVVGAGGDTEPEGTGAPVLSDGGTEGSGMGAMDEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V7</accession>
    <name>Q1D0V7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppa</name>
        <name evidence="7" type="ORF">MXAN_5577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555531.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5577"/>
    <dbReference type="EnsemblBacteria" id="ABF88859">
        <property type="protein sequence ID" value="ABF88859"/>
        <property type="gene ID" value="MXAN_5577"/>
    </dbReference>
    <dbReference type="GeneID" id="41362824"/>
    <dbReference type="KEGG" id="mxa:MXAN_5577"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_2_1_7"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="245" mass="27222" checksum="23F3B7ED092C1CD8" modified="2006-07-11" version="1">MKKPIQTTSQAHPWHGITPGEDAPEIVTAYIEIVPTDAVKYELDKESGILKLDRPQRFSSQCPTLYGFIPQTYCDELVAKRCAERTGLKDIKGDGDPIDICVLTEKVISSGNLLVRAIPIGGFRMVDGDEADDKIIAVLESDLVYGELQHLAQLPRALLDRLKHYFLTYKQIPGEGKRSVEIAEVYDQPEALEVIKRSMKDYERIYGPQVTTKARAVRTRGAAVEAKIAKPAKAKTKAARKSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D0V8</accession>
    <name>Q1D0V8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555530.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5576"/>
    <dbReference type="EnsemblBacteria" id="ABF91217">
        <property type="protein sequence ID" value="ABF91217"/>
        <property type="gene ID" value="MXAN_5576"/>
    </dbReference>
    <dbReference type="GeneID" id="41362823"/>
    <dbReference type="KEGG" id="mxa:MXAN_5576"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688538_0_0_7"/>
    <dbReference type="OrthoDB" id="1261786at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="447" mass="48660" checksum="6118611A0CDB2173" modified="2006-07-11" version="1">MPREPTRRLLPALAASMGVHGLLWLTLEREEPVARPPPASSPPALEWVDVEVAEARVSRDTLMPDKGPVAGAAQPVPPKRSDSVHAPPAPRTAAKHRAPSGKPAPERDAAPAQAESRSERHTEPTHASSQPAHDTQVAQADARPERHAEAQDSAPALLRFADAPLTGTPPTDMPRAEPGTNAVPGSRLLLAARQVTALSGTHRDVAAELDGGVDPHAPPSAQGLVEELVSESVGRGRVERGLVHPYYGQLGKALMKAWDADRSVKAHGLQGYFDMGMERGRAYSRIWAERAADYGASGSFAAKNGPGEDRRRPLSTAGDPTLNARRELRQQMRQEFRTTRRALIRVVQDATGQLVDVHLLEPSHQPEVDKEALKDVRATAEKLPPPPDEAVGGRSRLTSVWEFELLISISPPIPTFSFEFDEALGFIDTRLPLDRRIYKRVRLVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1B7</accession>
    <name>Q1D1B7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5409"/>
    <dbReference type="EnsemblBacteria" id="ABF88831">
        <property type="protein sequence ID" value="ABF88831"/>
        <property type="gene ID" value="MXAN_5409"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5409"/>
    <dbReference type="HOGENOM" id="CLU_2667278_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="75" mass="8465" checksum="D03C28713D55EF6E" modified="2006-07-11" version="1">MADAAPSSRNFFTALSFFGFSSSDFLSREMASSFRPPRSPRPGCRGCCRPRGRGARSPRTASPRRRQRPCESYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1D7</accession>
    <name>Q1D1D7_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555351.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5389"/>
    <dbReference type="EnsemblBacteria" id="ABF88163">
        <property type="protein sequence ID" value="ABF88163"/>
        <property type="gene ID" value="MXAN_5389"/>
    </dbReference>
    <dbReference type="GeneID" id="41362656"/>
    <dbReference type="KEGG" id="mxa:MXAN_5389"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061176_0_1_7"/>
    <dbReference type="OMA" id="DRFGYWP"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="2">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF88163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="377" mass="41297" checksum="26E4CE9F6724E69F" modified="2006-07-11" version="1">MTTTRRDLLKFGALAAASAALPGWAKPSKPIKRAAKPLNILILGGTGFTGPFQVNYALARGHKVTLFNRGKRPSPEWPSAVEQLFGDRNTGDLKSLQGRKWDVCIDNPTSLPFWVRDAGKVLKGNVGHYLFISTISVYADGSKQGITEDAPLAVYEGKDAMAETQDSLRADIEHLYGPLKALSEAEAHKQFGKRVTIVRPGYIVGPRDETDRFTYWPHRVAQGGEMLVPGDGSDPMQIIDGRDLGEWMIRLAETGTLGTFNAVGPAKPLSTTAMLKGCERVTGKKPTYTHVSPEFLEEKKVELPIWVSSKSGPYAGYGAVSNTRAMAAGLTYRPFDTTVTDLLAWFRSQPAERQATLRAGITREQEAALLKEWHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1H5</accession>
    <name>Q1D1H5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M23 peptidase domain protein</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555313.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5348"/>
    <dbReference type="EnsemblBacteria" id="ABF91298">
        <property type="protein sequence ID" value="ABF91298"/>
        <property type="gene ID" value="MXAN_5348"/>
    </dbReference>
    <dbReference type="GeneID" id="41362617"/>
    <dbReference type="KEGG" id="mxa:MXAN_5348"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_2_4_7"/>
    <dbReference type="OMA" id="DHGYGIK"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="204"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="305" mass="33515" checksum="422FF313972B3098" modified="2006-07-11" version="1">MAKKSFTLMVIPDHDAPVKRYTIQRSFLTQVGMGLMLVVGLGVGASVHYFQVAADASENRILREENLTLRSQLKSVRERIEHIGSTLDRVERFDQKLRAVTLLSDPQRNLAMGPTEPEAGTSAPATDTQFTQLTSTETPKALMGRLDRLSAEATRQEQSLQELQAYFQDQKSLLASTPSIWPARGWVTSDFGSRLDPYTADRVMHGGMDIAAPHGKEVFAPSDGTVVFAGLEGGYGNVLVIDHGYGIKTRYGHLSKMLVKAGDKVKRGMHIAAVGNTGRSTGPHLHYEVRVNGIGQNPRKFILEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1I0</accession>
    <name>EFTS_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">MXAN_5343</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555308.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D1I0"/>
    <dbReference type="SMR" id="Q1D1I0"/>
    <dbReference type="STRING" id="246197.MXAN_5343"/>
    <dbReference type="EnsemblBacteria" id="ABF86358">
        <property type="protein sequence ID" value="ABF86358"/>
        <property type="gene ID" value="MXAN_5343"/>
    </dbReference>
    <dbReference type="GeneID" id="41362612"/>
    <dbReference type="KEGG" id="mxa:MXAN_5343"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_7"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000006135" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="217" mass="24147" checksum="7553FA06C4355BF2" modified="2006-07-11" version="1">MAEVSAQMVKELRERTNAGMMDCKKALAESGGDFAKAEEWLRKKGIAKAAGKEGRVASEGIIGTYVHSGRIGVIVEVNCETDFVARNPDFQELVKDVAMQIAAAGPKFVRREEVPTDNLDKEKDIQREILKQQGKPEAMLEKILVGKMEKYYEGVCLVDQLWVKDDKKKVGEMISERAAKIGEKVSVRRFVRYELGEGIEKKKDDLAAEVAKTLGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1Q1</accession>
    <name>Q1D1Q1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_5270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555237.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF92282">
        <property type="protein sequence ID" value="ABF92282"/>
        <property type="gene ID" value="MXAN_5270"/>
    </dbReference>
    <dbReference type="GeneID" id="41362548"/>
    <dbReference type="KEGG" id="mxa:MXAN_5270"/>
    <dbReference type="HOGENOM" id="CLU_862845_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187810" evidence="2">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="322" mass="35078" checksum="D60CC9EF73E2C8DC" modified="2006-07-11" version="1">MKSKCTIRLGILLMAGLVSAGCGDGLGEAQAPIDLSPSSLNAARLSFQHIDRLYESDPAAAMEASRRLRPKLDELNQLLARVEVSREHFIEFYDLQPGGILVVERGPVADGRVLRDGDVARHSAVELYRQLTQGATPPTALVSAESRRAVPDDAQVIVRDEAAPHLESSGGFAPDLGEQGRDGFSSVTQPLTSADGPFWRDSVCYKGGDFFDCWSNVTGNGWAAADAKTSFTQLAPYRGTVGLWVSYESSVKAAWNVAAGEWFSFHQYSGTYWTCPPLVACGSTDYYIRNHRWDVTDAVGDGYHFTYAFRRNCSGGLCTYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1S9</accession>
    <name>Q1D1S9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88621">
        <property type="protein sequence ID" value="ABF88621"/>
        <property type="gene ID" value="MXAN_5242"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5242"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092398_0_0_7"/>
    <dbReference type="OMA" id="HYTARYP"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="263" mass="27538" checksum="DAEDCC47E0F9E31D" modified="2006-07-11" version="1">MSKVPQGKHGERPGVSGLSATSSTAGVIDERVDARRLPTKRMALLLPFPRFPREQRSHCTMRFFKMSVYLCTAVLFPACGGEDGVTGQDDALAQQESAVSSVSLDGCIYSISAYPQPNVTPTVYDVKLFRQPIPTCVYGYGSVTLGTSIVYEPTRSVAGNALGIAASYTKKSSLSGSAPITLSVHHVDPATLTVIRSSGLGVFLGAGNIVSENVAIAADGTTVTVSGSKTGVISGESGSGSHYTARYPDFFTSTTPPTIMAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1T9</accession>
    <name>Q1D1T9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudouridine synthase, RluA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_5232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555199.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5232"/>
    <dbReference type="EnsemblBacteria" id="ABF91513">
        <property type="protein sequence ID" value="ABF91513"/>
        <property type="gene ID" value="MXAN_5232"/>
    </dbReference>
    <dbReference type="GeneID" id="41362513"/>
    <dbReference type="KEGG" id="mxa:MXAN_5232"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_3_0_7"/>
    <dbReference type="OMA" id="PNDGQHA"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="92"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="303" mass="33897" checksum="4F8230351950C8A6" modified="2006-07-11" version="1">MRVLLNDGYVYREKLGRRPGSSALAHMTDKYRHSSEEEWRARFARGEVRLDDVTADGSEPLRPGQWLCWHRPPWEEADTPQSFELVYEDAELVVVVKPSGLPTLPSGGFLKNTLLSFVQARWPEAVPMHRLGRATSGLVLFTRTRDAAARLASDWREGRVHKRYRALSQGLAAQESYDIRAPIGLVPHPRLGEVHGASARGKPSHSTARVLERRTEHTLFEVDIHTGRSEQIRIHLAFIGHPLVGDPLFAVGGLPLAENPGLPGDGGYLLHAESLTFQHPRSGEHVQLQAPAPLELRVQDSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D1W6</accession>
    <name>Q1D1W6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rpoD</name>
        <name evidence="11" type="ORF">MXAN_5204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011555174.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1D1W6"/>
    <dbReference type="STRING" id="246197.MXAN_5204"/>
    <dbReference type="EnsemblBacteria" id="ABF92816">
        <property type="protein sequence ID" value="ABF92816"/>
        <property type="gene ID" value="MXAN_5204"/>
    </dbReference>
    <dbReference type="GeneID" id="41362486"/>
    <dbReference type="KEGG" id="mxa:MXAN_5204"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_7_2_7"/>
    <dbReference type="OMA" id="RDAKKEM"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007631">
        <property type="entry name" value="RNA_pol_sigma_70_non-ess"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA70_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="10">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
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        <location>
            <begin position="553"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="642"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="425"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="498"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF92816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="708" mass="80399" checksum="0942B5FD5642FD1B" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D230</accession>
    <name>RL31_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name type="ordered locus">MXAN_5139</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="mxa:MXAN_5139"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L28p-like"/>
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        <property type="entry name" value="Ribosomal_L31_A"/>
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        <property type="entry name" value="Ribosomal_L31_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword id="KW-1185">Reference proteome</keyword>
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    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
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        </location>
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        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <sequence length="73" mass="8113" checksum="4314CF590A713601" modified="2006-07-11" version="1">MKPEIHPVYPPSRVTCMCGNVVETKSTRGSFSVEICSNCHPFFTGKYKLVDTAGRIDRFRKKYGASPTSAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2D0</accession>
    <name>Q1D2D0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosomal RNA large subunit methyltransferase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">MXAN_5038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_5038"/>
    <dbReference type="EnsemblBacteria" id="ABF86126">
        <property type="protein sequence ID" value="ABF86126"/>
        <property type="gene ID" value="MXAN_5038"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_5038"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050931_1_0_7"/>
    <dbReference type="OMA" id="MTPHGWR"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016718">
        <property type="entry name" value="rRNA_m1G-MeTrfase_A_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018249">
        <property type="entry name" value="MyrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018249-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF86126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="32139" checksum="CF53D2CC5627C928" modified="2006-07-11" version="1">MSAPASPRFPPPLLPLLCCPICQSPLRQEATALRCVARHGFDVARQGYVNLLPGHRAPGNADTQSMVAARETFLARGHYEPLAALLAEHAARLTGADATEGCVLDVGAGTGHYLARVLDRCPALTGLAIDISRFAARRAARAHARAGALIADGERTLPIRNHSVALALSVFAPRNVTELHRILNRRGALLIVTPTDQHLTQLIQPMGLLSVDARKEERLHTRLRATFKPGVREALELTLRLTRDDAFHIAAMGPSAFHASTEELRRRADVLPELLTVSASFTVASYHRVERNGSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2H8</accession>
    <name>Q1D2H8_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554967.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4989"/>
    <dbReference type="ESTHER" id="myxxd-q1d2h8">
        <property type="family name" value="Aclacinomycin-methylesterase_RdmC"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87709">
        <property type="protein sequence ID" value="ABF87709"/>
        <property type="gene ID" value="MXAN_4989"/>
    </dbReference>
    <dbReference type="GeneID" id="41362273"/>
    <dbReference type="KEGG" id="mxa:MXAN_4989"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_0_0_7"/>
    <dbReference type="OMA" id="SHSSGPY"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="31378" checksum="AA77ACF000672F9A" modified="2006-07-11" version="1">MSERIIESGDIRLCTEGFGREGDAPVLMLMGAASSMLGWPDGLMEQLARAGRFVIRYDHRDTGRSSHGVPGATPYTLDDLAADVISVLDGYGIERAHLVGMSLGGLLCQLVALKYPERVLSLTLISAQIFSEPDFEDPGMDPAVLAHFQRAATLNWSDEAEAIGFQVELSRLCVGRARRSFDEARVRARAVQDYRRALAPQCALNHAGLSGGLEWYGRTREIEAPLLVIHGSVDPVIDHAHGVALSRAVKGACLVTLHDAGHDLHPDDWETMTRAITAHTSAASPPHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2M3</accession>
    <name>Q1D2M3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554922.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF88059">
        <property type="protein sequence ID" value="ABF88059"/>
        <property type="gene ID" value="MXAN_4944"/>
    </dbReference>
    <dbReference type="GeneID" id="41362229"/>
    <dbReference type="KEGG" id="mxa:MXAN_4944"/>
    <dbReference type="HOGENOM" id="CLU_1925328_0_0_7"/>
    <dbReference type="OMA" id="NCAWPGA"/>
    <dbReference type="OrthoDB" id="1957223at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="131" mass="14159" checksum="5D0BFA66F2CC36AC" modified="2006-07-11" version="1">MKKLNTLGVVGLLSLAAVGCGGEYTPEEEQAMQQPELSDVEQAMESAWIDAGQTRDFSTWLFGVTPFSIQNVGTAPTSYYAYCGSNNISGTVNVGQTHSNLNLNCAWPGARLYVSNTSGTVGTHKLYVWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D2V5</accession>
    <name>Q1D2V5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN variant repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554843.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4859"/>
    <dbReference type="EnsemblBacteria" id="ABF88080">
        <property type="protein sequence ID" value="ABF88080"/>
        <property type="gene ID" value="MXAN_4859"/>
    </dbReference>
    <dbReference type="GeneID" id="41362152"/>
    <dbReference type="KEGG" id="mxa:MXAN_4859"/>
    <dbReference type="eggNOG" id="COG2849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139741_0_0_7"/>
    <dbReference type="OMA" id="NGRREQY"/>
    <dbReference type="OrthoDB" id="1732940at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011652">
        <property type="entry name" value="MORN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07661">
        <property type="entry name" value="MORN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187831" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="17328" checksum="2CEEC2629CDCD59F" modified="2006-07-11" version="1">MLSTKLMRTLTLGLTLVAPAAMAEGASERLNCAEGTVQLGSKEEGLSCVKSGTKAGARTSHGAYVEYHPNGVKAAQGQFENGLKVGTWTFYDASGNKRGTAEFKDGGWHGQRVMYFPSGKPQRIEEYKNGRKNGVVKDLAEDGRVLSQVRYENNREVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D317</accession>
    <name>Q1D317_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554781.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4794"/>
    <dbReference type="EnsemblBacteria" id="ABF92606">
        <property type="protein sequence ID" value="ABF92606"/>
        <property type="gene ID" value="MXAN_4794"/>
    </dbReference>
    <dbReference type="GeneID" id="41362093"/>
    <dbReference type="KEGG" id="mxa:MXAN_4794"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="MSGPHYY"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF92606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="148" mass="16015" checksum="577594A27E41C321" modified="2006-07-11" version="1">MSPLAENDGALQRRSSQVGGGRLARLATDNGARRVLVVDDDADWREFLRLSLEDLGYETTEASDGQEALETLRRGGRYGVMLLDLNMPGMSGLDVVEHLPRGPHPRIVFLTSAAAQDVGSALLSGPHYYLPKGASRDQLSLLLQSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D363</accession>
    <name>Q1D363_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554735.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4748"/>
    <dbReference type="EnsemblBacteria" id="ABF92531">
        <property type="protein sequence ID" value="ABF92531"/>
        <property type="gene ID" value="MXAN_4748"/>
    </dbReference>
    <dbReference type="GeneID" id="41362047"/>
    <dbReference type="KEGG" id="mxa:MXAN_4748"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_1_7"/>
    <dbReference type="OMA" id="CKGVMGR"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="166"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="296" mass="30766" checksum="089E08EB120D59A0" modified="2006-07-11" version="1">MKVGFIGLGNMGLPMAASLAAAGHELTVWNRTESKAAPLKEKGARVARSPAEAARGAEVVFSMLADDAAVTSAVFGQDGLLAGLAPGAVHVSSSTLSVALSERLAEAHASAGQRYLAAPVFGRPTAAASKQLWVVAAGPKQDMDRCRPLLETLGRGLTVLGDRAPAANVVKLSGNFLIASMMEALAESFALTRKSGIEPKVFLEVFQSVFARAPIFEGYAQLIAEEKYSPAGFKMRLGLKDVELVLGAARTAEVPMPLASLVKDQFLGGVAQGHGDLDWSALGALVAERAGLKQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3A0</accession>
    <name>Q1D3A0_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="3 13">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">lpxK</name>
        <name evidence="14" type="ORF">MXAN_4711</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the LpxK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554698.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4711"/>
    <dbReference type="EnsemblBacteria" id="ABF86849">
        <property type="protein sequence ID" value="ABF86849"/>
        <property type="gene ID" value="MXAN_4711"/>
    </dbReference>
    <dbReference type="GeneID" id="41362010"/>
    <dbReference type="KEGG" id="mxa:MXAN_4711"/>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038816_6_0_7"/>
    <dbReference type="OMA" id="MDDGFQN"/>
    <dbReference type="OrthoDB" id="1382484at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABF86849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="397" mass="43232" checksum="A9AD17B0B5F0FA87" modified="2006-07-11" version="1">MTSPDAPTAIERVFYPPSPEPWGRRALLSPLTLLSWTYAAAVHVRGALFDAGLLRAERVEGLKVISVGNVNVGGTGKTPAVLHLAEQLVQAGRKVGILTRGYGRASREPLTFIGTEPLPSSDLAGDEPLLLARRCPQVRLFVGSDRVASAYRARDDFSLDTVLLDDGFQHRRLARDEDFVVVDESVGLGNGHMLPRGPLREPPASLRRATLFWLRAPATASDAAVLPVMRPEDTRTPQSTTHLLVPTEARSERFSDTLGGWLPSSPGIPRVRTRYRPTAWVDPEGNLHPVTALTGQPVFALAGLARPGGFLKTLQSLGTDVRDAALFPDHHRFTADELRDVQARAVRLGARVVTTEKDAVRLPQGFEAWVVRLGVEVLEGESHLRRALGLEDAPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3P1</accession>
    <name>Q1D3P1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoisovalerate dehydrogenase complex, E1 component, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_4564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554559.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4564"/>
    <dbReference type="EnsemblBacteria" id="ABF89138">
        <property type="protein sequence ID" value="ABF89138"/>
        <property type="gene ID" value="MXAN_4564"/>
    </dbReference>
    <dbReference type="GeneID" id="41361865"/>
    <dbReference type="KEGG" id="mxa:MXAN_4564"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_7"/>
    <dbReference type="OMA" id="WSSRPAN"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="27"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="336" mass="37106" checksum="A322EDB2BB061E11" modified="2006-07-11" version="1">MSRPRLIKESSEASAPLERELLVRIHDLMVKTRVLEERLIQMYKQGHGYFWIGGPGEEAFNVSLGLLMKKGQGPDFDYLHAHYRQSGTLLALGEEPIGSLRQMKNTATDPYSGGRNFAGHYSARKYNVAPVSSPIEVQYAIAPGTAMVQKRHGGDGITIVTGGDAGTAEGDFASCLVWSSRPANPLPILIIVTNNKWGISTAAEGQHGEQRISDRGKAFGIRSKTINGNDAVEAYTELREAMAYVRTERKPFLLEANVSRLYGHSSASGANYVSNEVDCLTDFEAKLEKDGVLTREQMDALRNSYTEEMAAAARQVRDEPQPDPESIWKHIYAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3S5</accession>
    <name>Q1D3S5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4530"/>
    <dbReference type="EnsemblBacteria" id="ABF89709">
        <property type="protein sequence ID" value="ABF89709"/>
        <property type="gene ID" value="MXAN_4530"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4530"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_2_7"/>
    <dbReference type="OMA" id="TFRWEED"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2290"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="2417" mass="259654" checksum="33D3810CE9787B73" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T1</accession>
    <name>Q1D3T1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF90264">
        <property type="protein sequence ID" value="ABF90264"/>
        <property type="gene ID" value="MXAN_4524"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4524"/>
    <dbReference type="HOGENOM" id="CLU_1553643_0_0_7"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188200" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="172" mass="18274" checksum="6545033C9977D758" modified="2006-07-11" version="1">MIGTLSKVVGLASLLLVASSADAAIQKKLIHMTVYSETGESAAFRAIDGQPVSATNETLKLSYRIVPEVIAPDTVRYTIYNGYDLESAAPIEVIEARADGKIHQGLRASFKVSVTTVEDRAMDINPLEAPSDNDKALKCCVTCGGWRYCCTPAAGYCCTVSTACGLGCRVCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D3T2</accession>
    <name>Q1D3T2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554518.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4523"/>
    <dbReference type="EnsemblBacteria" id="ABF86831">
        <property type="protein sequence ID" value="ABF86831"/>
        <property type="gene ID" value="MXAN_4523"/>
    </dbReference>
    <dbReference type="GeneID" id="41361825"/>
    <dbReference type="KEGG" id="mxa:MXAN_4523"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039717_0_0_7"/>
    <dbReference type="OMA" id="VLFPYIP"/>
    <dbReference type="OrthoDB" id="803484at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF86831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="418" mass="44487" checksum="ABD312481DD2F72C" modified="2006-07-11" version="1">MIPLPPLRGAAPSIHWSHTMQWRALPCVLALSLGACSDPEPEAPRPLKVVLFPYIPDSAGDGFASLKQRLEADFEREHSDIDVDIVFDAKLDLYDLDDGGTLNQLLGPGAGAAQVVEIDTLIMGELVSKGWVQPVALEAGAAHPAAEEAVSIAGQSYGVPTYLCSYVVYSNSPYLSSATDGDSLVQILTDVAPGMRPLAANYSGSWTLPSSYLDAWADTNPTGVLSQALSLPLDASALASFEDVVKSCELEAGVNPCLDGTYADSSLAEEAFALGQANGFMGYTERLFFVRKASPGMALPEVISVPLGTGSAPAVFVDALVVSAECTGTCAEDAHAFTDFMKDPDVRSLIAFSGDAPQGTTPRYLLQATQAFYQQEPARSDPMYQKYVQFLSGARPYPNQGFPQNRKTLQSALMDALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D407</accession>
    <name>Q1D407_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">MXAN_4445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554444.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4445"/>
    <dbReference type="EnsemblBacteria" id="ABF92668">
        <property type="protein sequence ID" value="ABF92668"/>
        <property type="gene ID" value="MXAN_4445"/>
    </dbReference>
    <dbReference type="GeneID" id="41361757"/>
    <dbReference type="KEGG" id="mxa:MXAN_4445"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282108_0_0_7"/>
    <dbReference type="OMA" id="QNISHEF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="430"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="676"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="799"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABF92668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123614" checksum="C17A0994AB060377" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D439</accession>
    <name>Q1D439_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554412.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4413"/>
    <dbReference type="EnsemblBacteria" id="ABF91708">
        <property type="protein sequence ID" value="ABF91708"/>
        <property type="gene ID" value="MXAN_4413"/>
    </dbReference>
    <dbReference type="GeneID" id="41361726"/>
    <dbReference type="KEGG" id="mxa:MXAN_4413"/>
    <dbReference type="HOGENOM" id="CLU_586391_0_0_7"/>
    <dbReference type="OMA" id="HELPMNI"/>
    <dbReference type="OrthoDB" id="819935at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="466" mass="51438" checksum="92278E465D521B5F" modified="2006-07-11" version="1">MSQLRDLSAVDALYASGYFGPKAHEAPEFYWASLMGALLPYKDDEGRPLGEEMAPSHVQAGVPMEMRECPYAGSRRKHAHPMNVSSLRQFNQHWPAVVGGLAVLRNAYLKQAQRPLDGPITMVDLWKFSRLGVALSAYLLRRGQLPLQDGHLPAVTAILYRMLLGINRVAHLQVLIIISAGLYDQMEALDPAVLYEFTDANELFIGMNSVCAGPRGLIEDSFRVLISGQLPPQADPGPVSALVSRPFLEYGNLLMGLDAQKYLFGVRATSLAHELSRQLSQPRAGEPGPGELAAALEAYQRRTEEQVSSLAREVAAAEQEVRERTVRDLERFRAELDQEQHAISGQGLGAQTRELEALTFPEDTPARVMALLEKARPAGPALRPFAEALTEYLRLERANLAIFERLQGRIEHALGRDGATLQLGNTDVMKAFGPKLRDFASEFFRLDIQSGAQRTVLRHGADTLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D451</accession>
    <name>Q1D451_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_4399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554400.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4399"/>
    <dbReference type="EnsemblBacteria" id="ABF88241">
        <property type="protein sequence ID" value="ABF88241"/>
        <property type="gene ID" value="MXAN_4399"/>
    </dbReference>
    <dbReference type="GeneID" id="41361709"/>
    <dbReference type="KEGG" id="mxa:MXAN_4399"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568089_0_0_7"/>
    <dbReference type="OMA" id="SRFHAWF"/>
    <dbReference type="OrthoDB" id="1632705at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="181" mass="19546" checksum="8137FF02E5F67280" modified="2006-07-11" version="1">MACEHPVRTPRMPEPLSAHVSRYLRNREVFERNLPAALLVFTPATEEDSGGDGEEYRLKTVTNAGNPTLGASGPLVFPVVKSRTNAFGRGITVGRTGNNDVVLDDGSVSRFHAWFSQEEGHAGFLLTDAGSKNGSWAGGVRLVPRKAVPVADGARLRFGQVEVGFYTTSGFMRMLAVRMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4B4</accession>
    <name>Q1D4B4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase, NUDIX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554337.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4335"/>
    <dbReference type="EnsemblBacteria" id="ABF91962">
        <property type="protein sequence ID" value="ABF91962"/>
        <property type="gene ID" value="MXAN_4335"/>
    </dbReference>
    <dbReference type="GeneID" id="41361647"/>
    <dbReference type="KEGG" id="mxa:MXAN_4335"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_7"/>
    <dbReference type="OMA" id="KLEYQFP"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF91962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="135" mass="15722" checksum="4851FC5E0BFEA807" modified="2006-07-11" version="1">MARRQVRVVGAMLQNEQGRYLITQRPPTASLPLLWEFPGGRVEEGEEDAEALAREIQEEMGVEVDVLGQAMHTHHEYPNYDIDFRVFHCRLSRPTEEVQHLRVHDHRWVTLEEMSAYRFPDADAKTLAKLLDLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4P7</accession>
    <name>Q1D4P7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative macrolide efflux ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_4201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554204.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4201"/>
    <dbReference type="EnsemblBacteria" id="ABF87999">
        <property type="protein sequence ID" value="ABF87999"/>
        <property type="gene ID" value="MXAN_4201"/>
    </dbReference>
    <dbReference type="GeneID" id="41361518"/>
    <dbReference type="KEGG" id="mxa:MXAN_4201"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_7"/>
    <dbReference type="OMA" id="MGSNMIT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="307"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="401" mass="42856" checksum="C96A890777C08E73" modified="2006-07-11" version="1">MGEIIRVAFDAVLANKLRSLLTMLGIVIGIAAVITMVALGEGAQRSVAQRLQGLGTNVLTVRPGQAFTGGMIRAQASMTIDDAEALRENARHIQAVAPEIESRFQVEYGAKNANLSVVGTWPDYFHVNQGQITNGRLFTDAEDKGRRRVVVLGALAGAQLGLTDTASLVGESIRIRGIPFEVIGVLAEKGAQGFNNPDESLYIPLSTAQFRVMGSDRIRSIAVQAVSDTAMDDAMAEIDQKLRREHRLRPEQPADFNIRDQASLLNTMQETTQTFSLLLAGIAAISLLVGGIGIMNIMLVSVTERTREIGLRKALGATGTDIMLQFLVESLVLCLAGGTLGLLLGMGGAAMLQRMAGWTVVVAPEAIIVAIAFSATVGVFFGIWPARRAASLAPIESLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U1</accession>
    <name>Q1D4U1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_4157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554160.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF86688">
        <property type="protein sequence ID" value="ABF86688"/>
        <property type="gene ID" value="MXAN_4157"/>
    </dbReference>
    <dbReference type="GeneID" id="41361476"/>
    <dbReference type="KEGG" id="mxa:MXAN_4157"/>
    <dbReference type="HOGENOM" id="CLU_844196_0_0_7"/>
    <dbReference type="OMA" id="RIDFALW"/>
    <dbReference type="OrthoDB" id="731698at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF86688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="329" mass="37123" checksum="3BCAF7AC08AA7943" modified="2006-07-11" version="1">MGPGGLDHVGDFSYHCRDKGTGDCRVKRYFGVIVIVAGVLLAAVMSYRSASGRALEAQRDADQQRIQAEYLERVGWMRANPDEASYRDELKPFFKNYFEQVDAHLTRFKGNTKFDDYLLELEKREESGAKDDRAKDRKAFYEYTRKTFDSLREGRYRPVWSATDKGMRLDIISSDVVMVLGKPQIRLQLAVWGAQRVLKDDGKVLKMVTSATFDTVWKLTDAKGKLLGEMRGADPSMKIDHPERFVRAFPPQMMLGHYDLDLLPNEVAKVEMTINLSSSAASGGTAASTYVWKLDVPSEWKLGAGETWEGATQEERPEEEIDPSKAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D4U6</accession>
    <name>Q1D4U6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="3">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">birA</name>
        <name evidence="5" type="ORF">MXAN_4152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554155.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4152"/>
    <dbReference type="EnsemblBacteria" id="ABF92438">
        <property type="protein sequence ID" value="ABF92438"/>
        <property type="gene ID" value="MXAN_4152"/>
    </dbReference>
    <dbReference type="GeneID" id="41361471"/>
    <dbReference type="KEGG" id="mxa:MXAN_4152"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_7"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="76"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="3">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="334" mass="36522" checksum="7451D61E08EA1D4E" modified="2006-07-11" version="1">MAANANEQTQEELILSFLSESGGDYTSGEALSSKLGLSRTAVWKHVEALRAKGYRIEAVSARGYRLVAVPDRLTSLEVGPLLDTRDLGRTIHHHESLPSTNEKAFRLAQDGARHGEVVVAEQQTAGKGRRGRTWVSPPGLNLYFSAILRPGLPPQRAPELTLVAAVALAESLRDAGVEAAIKWPNDVHIDGLKVAGILTELSAEPERVHFVIVGVGVNLNSQVEHFPEELRATATSLSLALGQPVHRARFAASLWTRLEEWLDLYLDTGFDAVRARWKALSSTLGQDVLVRTDRHELRGRAEDIDPSGALLVRTAEGSLERVLAGDVEQLRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D522</accession>
    <name>Q1D522_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="2">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_4073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4073"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF89453">
        <property type="protein sequence ID" value="ABF89453"/>
        <property type="gene ID" value="MXAN_4073"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_4073"/>
    <dbReference type="eggNOG" id="COG3934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696035_0_0_7"/>
    <dbReference type="OMA" id="GEGHFFW"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="entry name" value="PTHR31451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="172"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="43217" checksum="343F13FB4736C6A5" modified="2006-07-11" version="1">MLEAVAASCSGGPAQHLDRLPSGAMVLNAYFLQEEATRDARRGAAESPVLEEVLAKASALGVRALRTNGHNDALSKVGDTAIQVAPLEYDEVALVGLDWVLTRARFHGVRLVLTLGNYWDAYGGARQYVEWAGLPRPVEGDARFFTDPVVVAHFKAHVARLLNRVNTVDGIRYGDHPAVLAWELLNEPRGRGLDKEGARLRAWIDDVAREVKTHAPGHLVGTGEEGFEPSPDGYDPGFWSRSGSPVLRTPGASFTRNTASPYIDFASVHFYPESWGLGGIDTAEAGARWIREHAAIARNLGKPLFVGELGLRNEGAFDVSQRRALYRGWLECMRKEGVGAGALWMFSTDARPEAWDDYTFYYRDGTQPGDPVNRYADLVMEAAAAERPGAAVSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D578</accession>
    <name>Q1D578_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_4015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011554025.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_4015"/>
    <dbReference type="EnsemblBacteria" id="ABF88451">
        <property type="protein sequence ID" value="ABF88451"/>
        <property type="gene ID" value="MXAN_4015"/>
    </dbReference>
    <dbReference type="GeneID" id="41361347"/>
    <dbReference type="KEGG" id="mxa:MXAN_4015"/>
    <dbReference type="eggNOG" id="ENOG5031F9T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1657871_0_0_7"/>
    <dbReference type="OMA" id="MAREMPL"/>
    <dbReference type="OrthoDB" id="1643361at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="160" mass="17725" checksum="96D02BFE7CF9093E" modified="2006-07-11" version="1">MNPAARADMESRADRALRRGELTEALRLYESLVRAFPADEGLALKLANARELLQPAELEVLEAARAEASIPLPVGPSSPVQEGERLFALGDYAGAAACYRRAVQERPDSELLKERLIELYGLAKAMPLQSPTDRALPDKPEPRLQALLDRVASRRRLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5L0</accession>
    <name>Q1D5L0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein transporter, outer membrane fimbrial usher porin (FUP) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553893.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3883"/>
    <dbReference type="TCDB" id="1.B.11.6.2">
        <property type="family name" value="the outer membrane fimbrial usher porin (fup) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87854">
        <property type="protein sequence ID" value="ABF87854"/>
        <property type="gene ID" value="MXAN_3883"/>
    </dbReference>
    <dbReference type="GeneID" id="41361216"/>
    <dbReference type="KEGG" id="mxa:MXAN_3883"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009120_6_0_7"/>
    <dbReference type="OMA" id="YTANRFR"/>
    <dbReference type="OrthoDB" id="120032at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015473">
        <property type="term" value="F:fimbrial usher porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000015">
        <property type="entry name" value="Fimb_usher"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042186">
        <property type="entry name" value="FimD_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30451">
        <property type="entry name" value="PTHR30451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00577">
        <property type="entry name" value="Usher"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004187917" evidence="1">
        <location>
            <begin position="31"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="784" mass="83739" checksum="EF7260A14F2CD3CD" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D5W2</accession>
    <name>Q1D5W2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Non-ribosomal peptide synthetase/polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">MXAN_3779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553792.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3779"/>
    <dbReference type="EnsemblBacteria" id="ABF87031">
        <property type="protein sequence ID" value="ABF87031"/>
        <property type="gene ID" value="MXAN_3779"/>
    </dbReference>
    <dbReference type="GeneID" id="41361111"/>
    <dbReference type="KEGG" id="mxa:MXAN_3779"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_222626_0_0_7"/>
    <dbReference type="OMA" id="HISGDGW"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="603"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2076"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3135"/>
            <end position="3210"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4193"/>
            <end position="4268"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5260"/>
            <end position="5335"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6325"/>
            <end position="6401"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="7354"/>
            <end position="7429"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="9672"/>
            <end position="9747"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="10735"/>
            <end position="10810"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="11807"/>
            <end position="11882"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="12865"/>
            <end position="12940"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="13924"/>
            <end position="13999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="5229"/>
            <end position="5255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="6304"/>
            <end position="6324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="6405"/>
            <end position="6424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="7314"/>
            <end position="7358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="9975"/>
            <end position="9994"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2111"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3170"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4228"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="5295"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="6361"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="7389"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="9707"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="10770"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="11842"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="12900"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="13959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF87031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="14274" mass="1551746" checksum="8B2B71725A26103A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D624</accession>
    <name>Q1D624_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M16 (Pitrilysin) family</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_3713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553730.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3713"/>
    <dbReference type="EnsemblBacteria" id="ABF92184">
        <property type="protein sequence ID" value="ABF92184"/>
        <property type="gene ID" value="MXAN_3713"/>
    </dbReference>
    <dbReference type="GeneID" id="41361046"/>
    <dbReference type="KEGG" id="mxa:MXAN_3713"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_7"/>
    <dbReference type="OMA" id="RLMRYEY"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="212"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="479" mass="51170" checksum="8B98C0375E24F592" modified="2006-07-11" version="1">MASRKSPSRKSPARPAKRAGGKAPVARKASPKRGAPRATTSALTLPTLHESTTSSGLKVIAAERGPLPMVSVRLVIRAGSATDPDGKHGLADFTARLLRRGTRLLNAQAIDEAVEFVGASLGVGVSEDTLSVALTTPSEHFVQMLDILGQLVREPTFPQSEVDDARERELAQFANDLDDPSIIADRAMVRALWGNHPYGHDVGGSSKSVKTFTRDDVVRFHQERMGPKVSMLIVVGAVDPQRVAAAAEDAFADWTGGPDAPVAIPAPERIALGGRVIIVDKPDQTQSQVRLGGPGMRMGHEDYFPATAMNIALGGGFTSRLMNEIRVNRGLTYGVSSWFDSMNAAGVFALSTFTKTESTREIIDVALAEIGGVREKGLKPRELADAQAYLAGLYPLRTETNESIAGSIAEARLHGLGDDWVERFRDRLRAVTPKQVVAAAKKYCFAQAPAVVVLGKADAVKKQLKGLGPITVVPASEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D648</accession>
    <name>Q1D648_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553706.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3688"/>
    <dbReference type="EnsemblBacteria" id="ABF87227">
        <property type="protein sequence ID" value="ABF87227"/>
        <property type="gene ID" value="MXAN_3688"/>
    </dbReference>
    <dbReference type="GeneID" id="41361023"/>
    <dbReference type="KEGG" id="mxa:MXAN_3688"/>
    <dbReference type="HOGENOM" id="CLU_2070579_0_0_7"/>
    <dbReference type="OMA" id="WRPYEDG"/>
    <dbReference type="OrthoDB" id="1796340at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF87227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="118" mass="12630" checksum="AADDC868D8010D48" modified="2006-07-11" version="1">MVGRADDAAWRPYEDGGSIGWMGTQGGTIARDEDFGGLARLTYELDDTRSFHAIACSVTGWLLYHRFFDNAAAATAAFEEMKPALEALLTQLPEGGPTSPANTRLAGPLLAAFTVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D692</accession>
    <name>Q1D692_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase</fullName>
            <ecNumber evidence="3">3.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11112"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58764"/>
            <dbReference type="EC" id="3.3.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="4">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ABF88819">
        <property type="protein sequence ID" value="ABF88819"/>
        <property type="gene ID" value="MXAN_3644"/>
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    <dbReference type="KEGG" id="mxa:MXAN_3644"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="reaction ID" value="UER00335"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like"/>
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        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ISCHRISMTASE"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0596">Phosphopantetheine</keyword>
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    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="215"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4 5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001111-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="299" mass="32663" checksum="E85BF816FA8AEB74" modified="2006-07-11" version="1">MALPAIAPYPMPGTTDLPKNKVSWTPDPSRAVLLIHDMQRYFVEAFTQGQSPVTELVANIQRLRQHCTALGIPVVYSAQPGGQTPEQRGLLLDFWGGGINGGPDQKRIIDALTPAEGDIQLTKWRYSAFRKTDLMDQMKKLGRDQILISGIYAHIGCLQTASDAFMSDVRPFLIADALGDFSLAHHQLALSYAAQLCAVTTTTQQVLDALGPVSTSSTLTREQVRAEVAELLQESPEALGDDDNLLERGMDSIRLMTLVEKWRAAGAETTFVELAERPTLADWFTLLSLGNTPASRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6A2</accession>
    <name>Q1D6A2_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">MXAN_3634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="ABF91141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="246197.MXAN_3634"/>
    <dbReference type="EnsemblBacteria" id="ABF91141">
        <property type="protein sequence ID" value="ABF91141"/>
        <property type="gene ID" value="MXAN_3634"/>
    </dbReference>
    <dbReference type="GeneID" id="41360972"/>
    <dbReference type="KEGG" id="mxa:MXAN_3634"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_18_1_7"/>
    <dbReference type="OMA" id="NRQHWNQ"/>
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    </dbReference>
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        <property type="match status" value="5"/>
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        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAAL/FAAC"/>
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    </dbReference>
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        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="619"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2034"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3094"/>
            <end position="3168"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4572"/>
            <end position="4647"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5630"/>
            <end position="5706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="5706"/>
            <end position="5741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="5707"/>
            <end position="5727"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2069"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3129"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4607"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="5741" mass="623307" checksum="10253558FC1C20C9" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6B1</accession>
    <name>Q1D6B1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553643.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3625"/>
    <dbReference type="EnsemblBacteria" id="ABF89851">
        <property type="protein sequence ID" value="ABF89851"/>
        <property type="gene ID" value="MXAN_3625"/>
    </dbReference>
    <dbReference type="GeneID" id="41360963"/>
    <dbReference type="KEGG" id="mxa:MXAN_3625"/>
    <dbReference type="eggNOG" id="COG2308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569634_0_0_7"/>
    <dbReference type="OMA" id="APYLFGR"/>
    <dbReference type="OrthoDB" id="517836at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF89851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="479" mass="52427" checksum="B7F570005938BB47" modified="2006-07-11" version="1">MSAPEPIPGGQFSPEVKALHGQLSPAAAAFLEFTKRVPEALSRHKFKPHEASPFITYELHAWPTFVEGPVARQMREVAPALCQLIKRAPRRLLGATDRAAAFYGLPHERAHAALDALARTDDARGAIGRGDFIHDGTAFKCVEFNLTAGVGGWETAIHVQQVLAQPAMQRFAMEQRLRVRQPRTLRDFFSNVVDTVRRDVNWEGECNIGILFSPSTLPEAGPAEQVSRFFTAQLQELLQPEGARGEVLLATYGSVESEPGAHLTLRGKRLHAVVEYDARDRLAMAGATYVAQAQAAFDARTVSLLNGPAQDVLDDKRNLALLWEHVTSPALSEAEQELVRRNVPWSCRVERTHVERDGARYLVPELLASQRESLVLKPGRDYGGESVLVGGTTSAADWDTAVRKALDVGGWVAQERVHPTPLHTLGPEGTVVPYIAVWGLFVLGETYGGHFLRMCPMRRGTGVVNVAQGAIVGALIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6L1</accession>
    <name>Q1D6L1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3518"/>
    <dbReference type="EnsemblBacteria" id="ABF89914">
        <property type="protein sequence ID" value="ABF89914"/>
        <property type="gene ID" value="MXAN_3518"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3518"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_7"/>
    <dbReference type="OMA" id="IAKCPIV"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="618" mass="67699" checksum="644FC5F28DF00285" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D6T1</accession>
    <name>Q1D6T1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">MXAN_3445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553478.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3445"/>
    <dbReference type="EnsemblBacteria" id="ABF90832">
        <property type="protein sequence ID" value="ABF90832"/>
        <property type="gene ID" value="MXAN_3445"/>
    </dbReference>
    <dbReference type="GeneID" id="41360793"/>
    <dbReference type="KEGG" id="mxa:MXAN_3445"/>
    <dbReference type="eggNOG" id="COG4625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564784_0_0_7"/>
    <dbReference type="OMA" id="FRVTHIY"/>
    <dbReference type="OrthoDB" id="494048at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABF90832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="483" mass="50528" checksum="2669606570EAC330" modified="2006-07-11" version="1">MAAHPGQAPRRHGGPVMALSLPGLAGYRRTWMLTSKNPQRFLHAALLCALSWSGQAMASGAEELAPTDAKARIHPQNARALLRAERLLASEPHFLPPPLPDCPGMIDHGVVRLGVAPAGHLNLPCPTNTVSSGTFGTRTIGLRYLPTNGEAAAPGSACEGWGVASADLGISGYSSADCGASSNLTAEINAPSPISTMSVVRVGNTFRVTHIYTPSPVTNHLYQVDVLIENIGTAFIADLRYTRGIDYDILPNTFSEYVTVAGTAGNPWVVSAVDNNFVSLDPLAINYSLMGGTGDFTNVGPGDLGAQFDFRLGSLAVGQVRSFRTFYGAAGNQADALNALSAVGASTYSLAKGNWNGTGDPLSPTGAPAGTFGATTGQPNTFMYGFRPPESPTSCTVECPRVLSHGVYTVDHSGDLDRCVVNGQYANNTVAVTYLFGERVEFICSDYGSPHGNPCNVGPGADTCNLAAFQSLCSSPTFAQYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7H1</accession>
    <name>Q1D7H1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_3201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3201"/>
    <dbReference type="EnsemblBacteria" id="ABF88263">
        <property type="protein sequence ID" value="ABF88263"/>
        <property type="gene ID" value="MXAN_3201"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_3201"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070581_0_0_7"/>
    <dbReference type="OMA" id="FVDNGDH"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF88263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="27684" checksum="40C72CA757A051E7" modified="2006-07-11" version="1">MDAMEYCPRCDTENPRDASVCRACGSPLRSGTMVMAVASVASRPQVSIRVVRADGGPESVVRMQRDTLTCGQQADISLTDDPFIMPLQVRFFFSGIRLAVEDVGGANGVFVRLRQERELPPGGELRLGRQRLVLEPIPTAATGPGGTQVWGSPDPGYRLRLVQLLEGGLRGGAFPLREGDNLLGREQGDLTFPTDGFVSGRHAVLQVRQDRLQVRDVGSSNGTFIRLSGPTFVDNGDHFLIGRQLLRVEIQAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L4</accession>
    <name>Q1D7L4_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Channel protein, hemolysin III family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_3156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553205.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3156"/>
    <dbReference type="EnsemblBacteria" id="ABF88447">
        <property type="protein sequence ID" value="ABF88447"/>
        <property type="gene ID" value="MXAN_3156"/>
    </dbReference>
    <dbReference type="GeneID" id="41360515"/>
    <dbReference type="KEGG" id="mxa:MXAN_3156"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_2_2_7"/>
    <dbReference type="OMA" id="LIPMAHA"/>
    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="256" mass="27524" checksum="668AB9C1A65F6134" modified="2006-07-11" version="1">MPLDARAPRASEAGRDVPRADARVTCDDYEQLMASPDGTDTLLLIESVKPRLRGVSHAVAFVAALLGCIQLALMPVRGPQYLADLVFGGSMVLMFGVSATYHRFTWGMDAYRRIQRFDHAAIYILIAGSFTPMATLDTTGDTSLYLLWLMWIAALTGAGLTLLGVHTSRGLRSALYVALGAVATPVMLRLPEVIGSGRVAWLVLGGVLYAVGAVIYARRWPDPIPTVFGYHEIFHLLVVAAAGVHYAVILDIVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7L6</accession>
    <name>Q1D7L6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">menB</name>
        <name evidence="4" type="ORF">MXAN_3154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002640507.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3154"/>
    <dbReference type="EnsemblBacteria" id="ABF92395">
        <property type="protein sequence ID" value="ABF92395"/>
        <property type="gene ID" value="MXAN_3154"/>
    </dbReference>
    <dbReference type="GeneID" id="41360513"/>
    <dbReference type="KEGG" id="mxa:MXAN_3154"/>
    <dbReference type="eggNOG" id="COG0447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_7_7"/>
    <dbReference type="OMA" id="IFKQTDA"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF92395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="297" mass="33013" checksum="A2B84868ADFB81EE" modified="2006-07-11" version="1">MVSDIFNPARWKAVEGFKFKDITFHRAVDQGTVRIAFNRPEVRNAFRPRTVDELSRALEATRFMTDVGCVLITGNGPSPKDGGWAFCSGGDQRIRGKDGYKYEGEEGESDPARLGRLHILEVQRQIRFLPKAVIAVVPGWAVGGGHSLHVVCDMTIASKEHAVFKQTDADVASFDAGYGSALLARQIGQKRAREIFFVGANYSAEEAFQMGMVNAVVPHAQLEEFALEWAAEINTKSPTAIKMLKYAFNLPDDGLVGQQLFAGEATRLAYGTDEAQEGRDAFVQKRKRDFKRFPWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D7X5</accession>
    <name>Q1D7X5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metF</name>
        <name evidence="11" type="ORF">MXAN_3039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011553095.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_3039"/>
    <dbReference type="EnsemblBacteria" id="ABF89592">
        <property type="protein sequence ID" value="ABF89592"/>
        <property type="gene ID" value="MXAN_3039"/>
    </dbReference>
    <dbReference type="GeneID" id="41360401"/>
    <dbReference type="KEGG" id="mxa:MXAN_3039"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025841_0_2_7"/>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF89592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="290" mass="32068" checksum="88CB8D89D487F2C3" modified="2006-07-11" version="1">MKIRNRLNPSDPCFSFEFFPPRTDEGEANLLKALEDLATLQPGFVSVTEGAGGSTRAKTVELVLRIKQEAGIEAMAHLTCGGHSPAELRTVLERLSAAKVDNVLVLRGDPPKGQTVFEPAPGGFRYASEMVRFIREEDFNFCLGGACYPEGHVETPSRDDDLRHLKAKVDAGLDFVVTQLFFDNAFYFDFVERARRAGINVPIVPGIMPITNYEQIQRFTRLCGATVPMRLALQLERVKDNPEAMAQLGVAHATVQCMELLSRGVPGIHFYTLNKSPATRMIVSALRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D896</accession>
    <name>Q1D896_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ORF">MXAN_2916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552976.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2916"/>
    <dbReference type="EnsemblBacteria" id="ABF89941">
        <property type="protein sequence ID" value="ABF89941"/>
        <property type="gene ID" value="MXAN_2916"/>
    </dbReference>
    <dbReference type="GeneID" id="41360284"/>
    <dbReference type="KEGG" id="mxa:MXAN_2916"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_7"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABF89941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="421" mass="43152" checksum="E8CB1C707B80783F" modified="2006-07-11" version="1">MDVKVLLLGSGGREHALAWKLSQSPMLTQLLCGPGNPGTAKLGTNVALRADAPEEVAAFAKREAVDLVVVGPEAPLVAGVADALADAGIPCFGPVAAGARIEGSKAFAKEIMAEAGVPTAAFQTFTDMAAAEAYAVAQGRIVVKADGLAAGKGVIVAHDVEAARAAVRAVGAMGVAGQTMVLEELLEGEEVSAMALCDGERYAMLPLSQDHKRVGEGDTGPNTGGMGAYSPAPFLSAAQLAEVGERVVAPTLAVLRRRGIPFRGVLYAGLMLTRGGPKVLEFNARFGDPETQVLMMQLGEDLLPLLDACARGALVPRTLVSALGASVGVVLAARGYPDAPEKGQRIEGLDAVPPDATVFLAGAEARDGGVVTAGGRVLTVCARGEDLAQARERAYAAVATVRFEGMHFRRDIGARGMKAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8G6</accession>
    <name>Q1D8G6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication-associated recombination protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552907.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2846"/>
    <dbReference type="EnsemblBacteria" id="ABF90902">
        <property type="protein sequence ID" value="ABF90902"/>
        <property type="gene ID" value="MXAN_2846"/>
    </dbReference>
    <dbReference type="GeneID" id="41360217"/>
    <dbReference type="KEGG" id="mxa:MXAN_2846"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_7"/>
    <dbReference type="OMA" id="HVEAGTF"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="53"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF90902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="48574" checksum="63141448A334CE00" modified="2006-07-11" version="1">MSAGPDLFSASVDVNRFAPLAERMRPRTPDEFIGQSHLLGPGRPLRQLIERKAIVSSLFWGPPGVGKTTLARMMATGVDAEFVILSAVSDGIPRIREVVAEAERLRNQYSRRTVLFVDEIHRWAKNVQEQALPHVESGLFVLLGATTENVSFEVRPALVSRCRVFQLKELTVADIQSALTRALGDSKRGLGARNLSVGEGALTLLAKGGVGDVRKALGALELAASLTADGAEITPETAREAVGTSLSRHDKDGDQHYDLLSALQKSCRGSNVQGAVFWAAKLLQTGDVASLWRRLKVIAVEDVGMAMPEAISVVRDCEEAFHAMGMPEGRICVAHAVVLLATAKKSNRAYAALDAALAALQEHPNAEPPLHIRNAPTELMKELGHGKGYQTPWNFKDHYVPGQTYLPAPLERSVFYRPSKEGYEAEIHERMSHWWREDKASRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D8R4</accession>
    <name>Q1D8R4_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Biosynthetic arginine decarboxylase</fullName>
            <shortName evidence="11">ADC</shortName>
            <ecNumber evidence="11">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">speA</name>
        <name evidence="17" type="ORF">MXAN_2742</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">Catalyzes the biosynthesis of agmatine from arginine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="11"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552809.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2742"/>
    <dbReference type="EnsemblBacteria" id="ABF88624">
        <property type="protein sequence ID" value="ABF88624"/>
        <property type="gene ID" value="MXAN_2742"/>
    </dbReference>
    <dbReference type="GeneID" id="41360120"/>
    <dbReference type="KEGG" id="mxa:MXAN_2742"/>
    <dbReference type="eggNOG" id="COG1166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027243_1_0_7"/>
    <dbReference type="OMA" id="AVEYTQH"/>
    <dbReference type="OrthoDB" id="164471at2"/>
    <dbReference type="UniPathway" id="UPA00186">
        <property type="reaction ID" value="UER00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06830">
        <property type="entry name" value="PLPDE_III_ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01417">
        <property type="entry name" value="SpeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040634">
        <property type="entry name" value="Arg_decarb_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041128">
        <property type="entry name" value="Arg_decarbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17810">
        <property type="entry name" value="Arg_decarb_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17944">
        <property type="entry name" value="Arg_decarbox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001336">
        <property type="entry name" value="Arg_decrbxlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01180">
        <property type="entry name" value="ARGDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01273">
        <property type="entry name" value="speA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="14">
        <location>
            <begin position="114"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarb_HB" evidence="15">
        <location>
            <begin position="393"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_decarbox_C" evidence="16">
        <location>
            <begin position="602"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate-binding" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11 12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001336-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABF88624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="696" mass="76966" checksum="C22B4295E454B77A" modified="2006-07-11" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D966</accession>
    <name>Q1D966_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodanese/MoeB/ThiF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552658.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2588"/>
    <dbReference type="EnsemblBacteria" id="ABF87944">
        <property type="protein sequence ID" value="ABF87944"/>
        <property type="gene ID" value="MXAN_2588"/>
    </dbReference>
    <dbReference type="GeneID" id="41359966"/>
    <dbReference type="KEGG" id="mxa:MXAN_2588"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_2_0_7"/>
    <dbReference type="OMA" id="YGAVYRF"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="399" mass="42813" checksum="6F7748A8E39E80E9" modified="2006-07-11" version="1">MGPAPGLYASDMARTFQTLLAGVKQEIREVSVDDVKRLLDARASVRLLDVREADEYAGGRLPGALHIPRGYLELRIESQVQRDEELVVYCAGGTRSALAAKTLKELGYERVASLAGGYNRWSDAALPVEKPFVLTAEQKERYRRHLSLPEVGEAGQAKLLQARVLLLGAGGLGSPAALYLAAAGVGTLGIVDSDVVDLSNLQRQVIHTRERQGQPKVASARAAIEALNPDVKVVGFEERLTSHNVLTILEGFDLVLDGGDNFPTRYLLNDACVMLGKPNVHGSIFRFEGQVTSFVPGQGPCYRCLYPAPPPPELAPSCAEAGVLGVLPGLIGLLQATEALKLILGQGAPLVGRLLTFDALGTRFQELKLRRDTQCPVCAPGATVELIDYERFCAAPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9M1</accession>
    <name>Q1D9M1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552507.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2432"/>
    <dbReference type="EnsemblBacteria" id="ABF87548">
        <property type="protein sequence ID" value="ABF87548"/>
        <property type="gene ID" value="MXAN_2432"/>
    </dbReference>
    <dbReference type="GeneID" id="41359816"/>
    <dbReference type="KEGG" id="mxa:MXAN_2432"/>
    <dbReference type="HOGENOM" id="CLU_086643_0_0_7"/>
    <dbReference type="OMA" id="LANNDGN"/>
    <dbReference type="OrthoDB" id="1612574at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="280" mass="28936" checksum="B3A2AD5ED9EEA2C8" modified="2006-07-11" version="1">MGAGPPTVREKPRFLQGAPLFPGCARPPNHRPESERPFQQGGEQALSGSTRAPSFSPTGDVASPPPPTHNNHRRTSMKKLVGVFATIAMLGTGTALANNDGNKPKDSSAAQGGSGQVGQSEIQQDTTIGRGTTTTPTAPGQGGSGTMGQKAPMGQKELNGRVVKAESDKIFVDMHGAVVPLEVDRSTRFSDPTLKKAKDLRPGQEIRASYEVKETKNVAKSISLSGTGGAGDPTLTPDSSINQDNNKGGSGMEQHEGTGGAGDSSTMNPDTGSNTSPDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9N8</accession>
    <name>Q1D9N8_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552490.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2415"/>
    <dbReference type="EnsemblBacteria" id="ABF89866">
        <property type="protein sequence ID" value="ABF89866"/>
        <property type="gene ID" value="MXAN_2415"/>
    </dbReference>
    <dbReference type="GeneID" id="41359798"/>
    <dbReference type="KEGG" id="mxa:MXAN_2415"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_7"/>
    <dbReference type="OMA" id="SMEFAPF"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="268" mass="29394" checksum="6531BBB16219358B" modified="2006-07-11" version="1">MSRKPDKPKPPPQHKRWEGKEKPDWLSRALARAGVFPQKEAEDAIRAGRVSINGRVAKMALTPVPPGATVKVDGLVVSLEAPPTRVLAFHKPAGLLSSTERQHRTGTVFEALLPQLPPELAGYTWHAVGRLDVDSTGLLLFTNDDKLVAHATSPDAHLPKRYVATVFSTASDERVEPLRRGMTLDDGPARPAKVNVRDEHTVEVTLTEGRHHQVKRMLGAVGLPVRALHREAVGSVDLEGIPEGTFRLLTDDEVREGLRYEGRTPFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9T3</accession>
    <name>Q1D9T3_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_2370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2370"/>
    <dbReference type="EnsemblBacteria" id="ABF91543">
        <property type="protein sequence ID" value="ABF91543"/>
        <property type="gene ID" value="MXAN_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2370"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1388927_0_0_7"/>
    <dbReference type="OMA" id="DDCRTER"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF91543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="186" mass="20318" checksum="2D32B98739EE00E4" modified="2006-07-11" version="1">MNVSQLLLERGFETATVSEALGQVGVALDVDRVYIFENATSPTGELLCNQRYEWTAAAASAQLDNPELQNVPYSEVMPSWVAPLSSGKAVQGPPRAFPSPARELLEAQDIRSLLVCPITVGGEWWGFVGFDDCRTERKWPPTEVSVLQALSNALAGSLRHARLRSMLSGVQSQLRTIIQRCETTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9T9</accession>
    <name>Q1D9T9_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_2364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2364"/>
    <dbReference type="EnsemblBacteria" id="ABF87629">
        <property type="protein sequence ID" value="ABF87629"/>
        <property type="gene ID" value="MXAN_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2364"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_0_2_7"/>
    <dbReference type="OMA" id="PKRASGY"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="469" mass="51244" checksum="D100BC1FFD3101BA" modified="2006-07-11" version="1">MAPLAEAANRKQEVDRYIHGFHQKGMFNGTALVATEGGILLKKGYGSANLEWKVPNAPDTKFRIGSITKSFTATVILQLVAEGKLQLDDPITKHLPDYRGDTGGRVTITHLLNHTSGIPSYTSAPHFRADSVNPYGVAEFVKKSCSGDLEFEPGTKYAYNNCGYYLLGALIEKLTGQTYAQAVQARIFGPLGMKDSGYDVTATVLPKRASGYTPRPGGYVNAPYIDMGQPYAAGSLYSTVEDLYRWDRAFYGDTLMPAELKQKMLTPGLQHYGFGWAIAPVQLHDGKTKLPGIFHSGGINGFSSLLVRLPERKEVVILLDNATHGDLQEIAGGVLSILHGIAPRQARMPIGTVMMESLGKGSTAEAIANYRALKKTKEAQYDFSESQLNTVGYHLLRDGRVVDAIEVFKLNVETFPKGANCYDSLGEAYAAHGDKEQAIANYRKSLELDPKNENAVKMLKELEQPAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9U5</accession>
    <name>Q1D9U5_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decarboxylase, pyridoxal-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">MXAN_2358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552433.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2358"/>
    <dbReference type="EnsemblBacteria" id="ABF89455">
        <property type="protein sequence ID" value="ABF89455"/>
        <property type="gene ID" value="MXAN_2358"/>
    </dbReference>
    <dbReference type="GeneID" id="41359742"/>
    <dbReference type="KEGG" id="mxa:MXAN_2358"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_7"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="92"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="342"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="480" mass="52717" checksum="953C937FF3674EF9" modified="2006-07-11" version="1">MSLKSRLLGTARRQVKQTLRPVLQRAMAPARNHIPASHWGLRDVPGQGLSLEGVPLAQLVERWGSPLHVVHMAALRRNAERFLAVPPGRTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEVISAYEMWLALKLGVPPERIVYNGPVKSEASVREAISRGIQLLAANHAEEIAVFARLAAELDRRPRVAVRVTTNSGWSAQFGTPIAGGAALRAYQQARGSKHLDVVGLHAHRGETIRTEGDFTAFVESVLDFTDTLHQELGLDLEVLDLGGSLNTPTVEHIAERDWRLNLTFFRDVPAPDPAASLSIDRYVALAVEMVETHYARRGRQRPRIFLEPGRAMTGDTQLLLGRVHALKAGEDRTWAVLDAGINHAECVRNEYHQLFHVNRPDAPADKVYTVVGPICTPGDTLYHAKRLPDLRVGDTLAIMDAGAYFVPFATSFSYPQPAIVALEDGKERLLRRAETFDDLVTFDALDSRAALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W5</accession>
    <name>Q1D9W5_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobA</name>
        <name evidence="11" type="ORF">MXAN_2338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DK1622</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF90524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552413.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2338"/>
    <dbReference type="EnsemblBacteria" id="ABF90524">
        <property type="protein sequence ID" value="ABF90524"/>
        <property type="gene ID" value="MXAN_2338"/>
    </dbReference>
    <dbReference type="GeneID" id="41359724"/>
    <dbReference type="KEGG" id="mxa:MXAN_2338"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_7"/>
    <dbReference type="OMA" id="MSFIEDA"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABF90524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="266" mass="27647" checksum="989534249A4CDE79" modified="2006-07-11" version="1">MREQTRGRVFLVGAGPGDPELLTLRAARVLREADTVVHDRLVHPGVLEHARPHARLIYVGKEGGGDSVSQEEIHVILIAQALLGRRVVRLKGGDPFVFGRGGEEALALEEAGIPYEVVPGLTAGTAVPAAAAIPVTHRGVSGAVTFATAYRGGSAPAWDFLAKAQTLVLYMAGSRLEETVRALVGAGRSASTPAAVVEAGTWAHQRVVEAPLSHIAQAATRDAIGSPSLLIVGEVVSLRGRLPSLVAQGTSEHGHAPARVAEGGHE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q1D9W6</accession>
    <name>CYSD_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfate adenylate transferase</fullName>
            <shortName evidence="1">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysD</name>
        <name type="ordered locus">MXAN_2337</name>
    </gene>
    <organism>
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DK1622</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552412.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q1D9W6"/>
    <dbReference type="SMR" id="Q1D9W6"/>
    <dbReference type="STRING" id="246197.MXAN_2337"/>
    <dbReference type="EnsemblBacteria" id="ABF91544">
        <property type="protein sequence ID" value="ABF91544"/>
        <property type="gene ID" value="MXAN_2337"/>
    </dbReference>
    <dbReference type="GeneID" id="41359723"/>
    <dbReference type="KEGG" id="mxa:MXAN_2337"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043026_0_0_7"/>
    <dbReference type="OMA" id="LMIDTGH"/>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00064">
        <property type="entry name" value="Sulf_adenylyltr_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000340208" description="Sulfate adenylyltransferase subunit 2">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00064"/>
        </source>
    </evidence>
    <sequence length="305" mass="35338" checksum="B6114720DD8F577A" modified="2006-07-11" version="1">MSEHTFARASHLSELEAESIHILRETVAEFANPVMLYSIGKDSQVLLHLARKAFHPAPLPFPLLHVDTTWKFRDMYAFRDAFVARHGLRLIIHRNQRALAEGINPFDHGSQKYTHAMKTQALLEALAAHGFDAAFGGARRDEEKSRAKERVFSFRDRHGQWDPRRQRPELWNLFNGRVDAGESMRVFPLSNWTELDVWHYVLRERIPVVPLYFAAERPVIDRGGTLLMVDDERMRLRPGEKPEIRRVRFRTLGCYPLSGAIESSATTVETVIHEMVNARQSERQGRLIDHDEEGSMELKKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DA37</accession>
    <name>Q1DA37_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnhA</name>
        <name evidence="7" type="ORF">MXAN_2265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DK1622</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF91338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552341.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q1DA37"/>
    <dbReference type="STRING" id="246197.MXAN_2265"/>
    <dbReference type="EnsemblBacteria" id="ABF91338">
        <property type="protein sequence ID" value="ABF91338"/>
        <property type="gene ID" value="MXAN_2265"/>
    </dbReference>
    <dbReference type="GeneID" id="41359653"/>
    <dbReference type="KEGG" id="mxa:MXAN_2265"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_3_0_7"/>
    <dbReference type="OMA" id="GGHEPET"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABF91338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="255" mass="27709" checksum="AB75DA36A067A858" modified="2006-07-11" version="1">MEHRPTLVFADGACSGNPGPGGWGSIIVTPDGLVTELGGHEPETTNNRMELTAVGKALRHLERAPGPIHIHTDSTYVIQGATKWAFGWSRRGWKTAEGGEVANAIYWKRLMALLAQRKESHAAEAAAVAWFYIRGHVGVPGNERVDAIAVAYSKGRDARLYTGPLHGYGVAVHDLPEDMSLPPEKPKEQREAAAKAYSYLSQVGSSVKRHASWAACERRVKGVSGARFKKTKSALDEAKVLEDWGFKGQDVPSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAK6</accession>
    <name>Q1DAK6_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide oxidoreductase resA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">resA</name>
        <name evidence="5" type="ORF">MXAN_2088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF92176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2088"/>
    <dbReference type="EnsemblBacteria" id="ABF92176">
        <property type="protein sequence ID" value="ABF92176"/>
        <property type="gene ID" value="MXAN_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_2088"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_7"/>
    <dbReference type="OMA" id="RYVGEPQ"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABF92176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="178" mass="19393" checksum="BF31841C9AA39120" modified="2006-07-11" version="1">MGGGTKLVLGLLGALGVGGVVFLGVLEAQRARLVPDGTTAPTMEMARHGGGTMKLEDLKGQVVMLDFWATWCPPCREEMPALVKLAKEYEPQGLVFVAASRDDGDRAPKLVEAFMRNHLPELAPYVVYADDNVARAFQVSALPTLYFLDRDGKVIDAQRGALSEDGIRRRIERALKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DAR6</accession>
    <name>Q1DAR6_MYXXD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">MXAN_2028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011552112.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_2028"/>
    <dbReference type="EnsemblBacteria" id="ABF88242">
        <property type="protein sequence ID" value="ABF88242"/>
        <property type="gene ID" value="MXAN_2028"/>
    </dbReference>
    <dbReference type="GeneID" id="41359438"/>
    <dbReference type="KEGG" id="mxa:MXAN_2028"/>
    <dbReference type="eggNOG" id="COG3148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715523_0_0_7"/>
    <dbReference type="OMA" id="GTARMAH"/>
    <dbReference type="OrthoDB" id="1719529at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/YfiP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="PTHR21392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="5">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABF88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="396" mass="44070" checksum="38866342C7763EA6" modified="2006-07-11" version="1">MAVRNLCLRCRRPESACYCAQLPPRLETRTRVVFLQHPRESRVAIGTARMAHLSLSNSELHEGVDFSGHRRIEELAAQRDSVAVLFPGEDAISVEEARLNPPKTLIVVDGTWPQAKKVVSRNPVLAGLPRIGFVPRRPSNYRIRAEPADHCVSTIEAVVEMLGILEGDPARFDTMLRAFEYMVDTQLERQSARTSPNRRRIYFGPWRPPLELRTLAERFEKLVVFYGEANAHPAGGEEIPTELVHAVACRPATGERFEAIIAPEQPLAYSTPLHVELSEDILRAGEPRAEAMKRFEAFLRPDDELAVWTTFALDLLWAGGITRRPASSVRLATARALKGKAGGVEQAMTLLQGPELPQWAPGRAGRRIRALESVVRELVARGNATEPPQKLPRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBD0</accession>
    <name>Q1DBD0_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">MXAN_1795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABF87440">
        <property type="protein sequence ID" value="ABF87440"/>
        <property type="gene ID" value="MXAN_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1795"/>
    <dbReference type="eggNOG" id="ENOG5032KDW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062434_0_0_7"/>
    <dbReference type="OMA" id="WFDADHG"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004188449" evidence="2">
        <location>
            <begin position="32"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABF87440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="349" mass="37314" checksum="A38D1C39E2894B02" modified="2006-07-11" version="1">MPSTARSNIDMHIRWIKATLLSTVLMGLAGACGGAPGADDASSVGGPGADDASSVGGPGADDASSVGGPGADDTSSDGGATDRFGIQMLYPTLASGKAWYAQWDSTPRSFNGVDPKDSWFDADHGNASYKIPGDGTLRISGSVPRMYVHDPAKQDPWRNVEITMYFKRVSDSGINWGGMVSFARTNHGTTGSENRDKCDTRGIGARMRYDGKIDFEKETNHPDSKYVVQKKYWSSSLPKNTWIGHKHVVYDLPGGKVKQELWIDLTDGVNGGQWTKINEFIDDGTQFGKGGSPCASGIDPALPLTAGSSRVGSESGKPNITVYFRSDGVSTDGLWYRWGSVREIQAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DBV7</accession>
    <name>Q1DBV7_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551725.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1614"/>
    <dbReference type="EnsemblBacteria" id="ABF87852">
        <property type="protein sequence ID" value="ABF87852"/>
        <property type="gene ID" value="MXAN_1614"/>
    </dbReference>
    <dbReference type="GeneID" id="41359058"/>
    <dbReference type="KEGG" id="mxa:MXAN_1614"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053129_0_0_7"/>
    <dbReference type="OMA" id="PRMAHTR"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="209"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABF87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="444" mass="48323" checksum="E30AEF1DB3EA25F8" modified="2006-07-11" version="1">MGVTDATASPRGARPEDTRLDWFVERREVTEVLHQRSGLRVIPPVLDQGWSMGQTTPDSMAWQWAQVAGARWKHGLMPEALAYQARPLLDAEPRLASDTEAMVSLVRQLEATARAAGAQHLDVLLREVERRTLSASDAHQREDHQRHALLEVKAFHDTGAGMAELWRCAAWPDVTGARTALPSLEALVESMARELRDTTPMVPCPRDVLPIVFPPGAASGCFFHEVCGHPLEGDVVARGGSYLARRLGQQVAGAHLSVSDDPTDGHGALGFAWDDEGHAALPVTLIREGRVDAPLLDARSAAALGRAPNGHGRRVSYRHPPLPRMAHTRVDAHQGHLEALMADIPHGLLVQHLTPRQMDLLSGDFSFYIVEAREIRNGRPGRRVGPGILRGNGLEALAAIDAVGADTKNLFATRGCRKLDHGPLPVSFGQPTVRFRGLTVEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DC52</accession>
    <name>Q1DC52_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">add</name>
        <name evidence="4" type="ORF">MXAN_1519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DK1622</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="246197.MXAN_1519"/>
    <dbReference type="EnsemblBacteria" id="ABF89646">
        <property type="protein sequence ID" value="ABF89646"/>
        <property type="gene ID" value="MXAN_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="mxa:MXAN_1519"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_0_0_7"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="Proteomes" id="UP000002402">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABF89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002402"/>
        </source>
    </evidence>
    <sequence length="355" mass="39221" checksum="06EC075BD40C0CC1" modified="2006-07-11" version="1">MTEELLRALPKTDLHCHLDGSMRLKTILELAEQQKIKLLADTEDGLAKAIHMGEVCESLEEYLVAFDVTLSVLQTAESLYRAAYELAVDAAAENVRWLEVRYSPALHLQKGLKMTTVIDSVLEGLRAAKRETGIKCGVIVCGIRHINPQTSMRLAELAVAYKNRGVIGFDLAGAEASFPAKDHRDAFQLILKNNVNCTAHAGEAYGPESISQAIHNLGAHRIGHGTRLREDGDLLNYVNDHRIPLEVCPTSNVQTGAVTSLAAHPLKFYFDYGLRVTINTDNRLITDTTVTKELWTAHSALGLSLEDLTTILVSGFKSAFLPFREKQDMLRAVNEEIAQTLAAFDQKRHLVKQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-07-11" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q1DCC1</accession>
    <name>Q1DCC1_MYXXD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">MXAN_1445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Myxococcus xanthus (strain DK1622)</name>
        <dbReference type="NCBI Taxonomy" id="246197"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Myxococcales</taxon>
            <taxon>Cystobacterineae</taxon>
            <taxon>Myxococcaceae</taxon>
            <taxon>Myxococcus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Proc. Natl. Acad. Sci. U.S.A." volume="103" first="15200" last="15205">
            <title>Evolution of sensory complexity recorded in a myxobacterial genome.</title>
            <authorList>
                <person name="Goldman B.S."/>
                <person name="Nierman W.C."/>
                <person name="Kaiser D."/>
                <person name="Slater S.C."/>
                <person name="Durkin A.S."/>
                <person name="Eisen J.A."/>
                <person name="Ronning C.M."/>
                <person name="Barbazuk W.B."/>
                <person name="Blanchard M."/>
                <person name="Field C."/>
                <person name="Halling C."/>
                <person name="Hinkle G."/>
                <person name="Iartchuk O."/>
                <person name="Kim H.S."/>
                <person name="Mackenzie C."/>
                <person name="Madupu R."/>
                <person name="Miller N."/>
                <person name="Shvartsbeyn A."/>
                <person name="Sullivan S.A."/>
                <person name="Vaudin M."/>
                <person name="Wiegand R."/>
                <person name="Kaplan H.B."/>
            </authorList>
            <dbReference type="PubMed" id="17015832"/>
            <dbReference type="DOI" id="10.1073/pnas.0607335103"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DK1622</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000113">
        <property type="protein sequence ID" value="ABF86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011551561.1">
        <property type="nucleotide sequence ID" value="NC_008095.1"/>
    </dbReference>
    <dbRef